OOIR: Observatory of International Research

Papers

(The TQCC of Molecular Therapy-Oncolytics is 18. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Metabolic remodeling in tumor-associated macrophages contributing to antitumor activity of cryptotanshinone by regulating TRAF6-ASK1 axis	139
Sperm protein 17 targeting for epithelial ovarian cancer treatment in the era of modern immunoengineering	107
Promoting role of pentraxin-3 in esophageal squamous cell carcinoma	107
The emerging role of off-the-shelf engineered natural killer cells in targeted cancer immunotherapy	76
Ferroptosis gene signature in cholangiocarcinoma	67
Deletion of immunomodulatory genes as a novel approach to oncolytic vaccinia virus development	63
esRAGE-expressing oHSV enhances anti-tumor efficacy by inhibition of endothelial cell activation	61
Efficacy of a third-generation oncolytic herpes simplex virus in refractory soft tissue sarcoma xenograft models	55
Spatiotemporal analysis of induced neural stem cell therapy to overcome advanced glioblastoma recurrence	50
Targeting carcinoembryonic antigen-expressing tumors using a novel transcriptional and translational dual-regulated oncolytic herpes simplex virus type 1	50
Lazertinib improves the efficacy of chemotherapeutic drugs in ABCB1 or ABCG2 overexpression cancer cells in vitro, in vivo, and ex vivo	50
SNHG1 knockdown upregulates miR-376a and downregulates FOXK1/Snail axis to prevent tumor growth and metastasis in HCC	49
Systematic profiling of ferroptosis gene signatures predicts prognostic factors in esophageal squamous cell carcinoma	47
Polymer stealthing and mucin-1 retargeting for enhanced pharmacokinetics of an oncolytic vaccinia virus	46
A novel anti-B7-H3 chimeric antigen receptor from a single-chain antibody library for immunotherapy of solid cancers	45
Synthetic mRNA-based gene therapy for glioblastoma: TRAIL-mRNA synergistically enhances PTEN-mRNA-based therapy	44
Reinvigoration of innate and adaptive immunity via therapeutic cellular vaccine for patients with AML	43
Transcriptional landscape associated with TNBC resistance to neoadjuvant chemotherapy revealed by single-cell RNA-seq	43
Efficacy of cancer-specific anti-podoplanin CAR-T cells and oncolytic herpes virus G47Δ combination therapy against glioblastoma	40
A New Tool for CRISPR-Cas13a-Based Cancer Gene Therapy	39
Anti-CAIX BBζ CAR4/8 T cells exhibit superior efficacy in a ccRCC mouse model	38
Oncolytic herpes simplex virus armed with a bacterial GBP1 degrader improves antitumor activity	38
The miR-23a/27a/24-2 cluster promotes postoperative progression of early-stage non-small cell lung cancer	37
Cancer stem/progenitor signatures refine the classification of clear cell renal cell carcinoma with stratified prognosis and decreased immunotherapy efficacy	37
Circular RNA circLAMA3 inhibits the proliferation of bladder cancer by directly binding an mRNA	37

miR-519d-3p suppresses tumorigenicity and metastasis by inhibiting Bcl-w and HIF-1α in NSCLC	37
lncRNA RP11-147L13.8 suppresses metastasis and chemo-resistance by modulating the phosphorylation of c-Jun protein in GBC	37
Knockdown of LRRN1 inhibits malignant phenotypes through the regulation of HIF-1α/Notch pathway in pancreatic ductal adenocarcinoma	36
Association of IDH mutation and 1p19q co-deletion with tumor immune microenvironment in lower-grade glioma	36
Circular RNAs act as regulators of autophagy in cancer	36
PROTACs in gastrointestinal cancers	36
Potential for reversing miR-634-mediated cytoprotective processes to improve efficacy of chemotherapy against oral squamous cell carcinoma	33
CAFs/tumor cells co-targeting DNA vaccine in combination with low-dose gemcitabine for the treatment of Panc02 murine pancreatic cancer	33
Preclinical evaluation of a novel antibody-drug conjugate targeting DR5 for lymphoblastic leukemia therapy	33
In vivo DNA-launched bispecific T cell engager targeting IL-13Rα2 controls tumor growth in an animal model of glioblastoma multiforme	32
miR-1207-5p suppresses laryngeal squamous cell carcinoma progression by downregulating SKA3 and inhibiting epithelial-mesenchymal transition	32
Oncolytic virotherapy with chimeric VSV-NDV synergistically supports RIG-I-dependent checkpoint inhibitor immunotherapy	32
Oncolytic adenovirus-mediated expression of decorin facilitates CAIX-targeting CAR-T therapy against renal cell carcinoma	32
Metformin inhibits gastric cancer cell proliferation by regulation of a novel Loc100506691-CHAC1 axis	32
Durable remission related to CAR-T persistence in R/R B-ALL and long-term persistence potential of prime CAR-T	32
Amplification of the CXCR3/CXCL9 axis via intratumoral electroporation of plasmid CXCL9 synergizes with plasmid IL-12 therapy to elicit robust anti-tumor immunity	30
Current development in adenoviral vectors for cancer immunotherapy	29
Intraperitoneal oncolytic virotherapy for patients with malignant ascites: Characterization of clinical efficacy and antitumor immune response	29
AAMP promotes colorectal cancer metastasis by suppressing SMURF2-mediated ubiquitination and degradation of RhoA	28
Replication-incompetent influenza A viruses armed with IFN-γ effectively mediate immune modulation and tumor destruction in mice harboring lung cancer	28
CircRHBDD1 augments metabolic rewiring and restricts immunotherapy efficacy via m6A modification in hepatocellular carcinoma	27
Bispecific CD33/CD123 targeted chimeric antigen receptor T cells for the treatment of acute myeloid leukemia	26
MMP25-AS1/hsa-miR-10a-5p/SERPINE1 axis as a novel prognostic biomarker associated with immune cell infiltration in KIRC	26
Cannabinoid receptors promote chronic intermittent hypoxia-induced breast cancer metastasis via IGF-1R/AKT/GSK-3β	25
Pan-cancer analysis reveals distinct clinical, genomic, and immunological features of the LILRB immune checkpoint family in acute myeloid leukemia	25
A library of cancer testis specific T cell receptors for T cell receptor gene therapy	25
The role and application of vesicles in triple-negative breast cancer: Opportunities and challenges	25
Advances and new frontiers for immunotherapy in colorectal cancer: Setting the stage for neoadjuvant success?	25
Radiovirotherapy at twenty	24
LINC01296 promotes neuroblastoma tumorigenesis via the NCL-SOX11 regulatory complex	24
Bacterial cancer therapy using the attenuated fowl-adapted Salmonella enterica serovar Gallinarum	24
BRD4: An emerging prospective therapeutic target in glioma	24
A PD1 targeted nano-delivery system based on epigenetic alterations of T cell responses in the treatment of gastric cancer	23
Oncolytic vaccinia virus injected intravenously sensitizes pancreatic neuroendocrine tumors and metastases to immune checkpoint blockade	23
Nucleic acids and proteins carried by exosomes of different origins as potential biomarkers for gynecologic cancers	23
Pre-treatment with systemic agents for advanced NSCLC elicits changes in the phenotype of autologous T cell therapy products	23
circBANP promotes colorectal cancer growth and metastasis via sponging let-7d-5p to modulate HMGA1/Wnt/β-catenin signaling	23
RETRACTED: Comprehensive analysis of FKBP4/NR3C1/TMEM173 signaling pathway in triple-negative breast cancer cell and dendritic cell among tumor microenvironment	23
Human lung adenocarcinoma CD47 is upregulated by interferon-γ and promotes tumor metastasis	22
Seneca Valley virus replicons are packaged in trans and have the capacity to overcome the limitations of viral transgene expression	22
Thank you to our 2021 reviewers	22
Oncolytic adenovirus for treatment of malignant ascites	22
Adding recombinant AAVs to the cancer therapeutics mix	22
Oncolytic Zika virus promotes intratumoral T cell infiltration and improves immunotherapy efficacy in glioblastoma	22
Diversity in responses to oncolytic Lassa-vesicular stomatitis virus in patient-derived glioblastoma cells	21
Interleukin-6-controlled, mesenchymal stem cell-based sodium/iodide symporter gene therapy improves survival of glioblastoma-bearing mice	21
Infection of non-cancer cells: A barrier or support for oncolytic virotherapy?	21
Thank you to our 2023 reviewers	20
Vaccinia virus and peptide-receptor radiotherapy synergize to improve treatment of peritoneal carcinomatosis	20
ScRNA-seq and bulk RNA-seq reveal the characteristics of ferroptosis and establish a risk signature in cholangiocarcinoma	20

Redirecting anti-Vaccinia virus T cell immunity for cancer treatment by AAV-mediated delivery of the VV B8R gene	20
DNA-damaging cancer cells to improve virotherapy	20
Enhancing the effectiveness of γδ T cells by mRNA transfection of chimeric antigen receptors or bispecific T cell engagers	20
Oncolytic herpes virus G47Δ works synergistically with CTLA-4 inhibition via dynamic intratumoral immune modulation	20
The quest for effective immunotherapies against malignant peripheral nerve sheath tumors: Is there hope?	20
Non-coding RNAs and glioma: Focus on cancer stem cells	20
Efficacy of coxsackievirus A21 against drug-resistant neoplastic B cells	20
Ubiquitin-related molecular classification and risk stratification of hepatocellular carcinoma	20
TTN-AS1 accelerates the growth and migration of nasopharyngeal carcinoma cells via targeting miR-876-5p/NETO2	19
Exosomal and intracellular miR-320b promotes lymphatic metastasis in esophageal squamous cell carcinoma	19
Multivalent in vivo delivery of DNA-encoded bispecific T cell engagers effectively controls heterogeneous GBM tumors and mitigates immune escape	19
Sodium iodide symporter-targeted gene therapy in glioblastoma	19
Oncolytic measles vaccines encoding PD-1 and PD-L1 checkpoint blocking antibodies to increase tumor-specific T cell memory	19
Targeting EGFR sensitizes 5-Fu-resistant colon cancer cells through modification of the lncRNA-FGD5-AS1-miR-330-3p-Hexokinase 2 axis	19
A new strategy for treating colorectal cancer: Regulating the influence of intestinal flora and oncolytic virus on interferon	19
An oral cancer vaccine using a Bifidobacterium vector suppresses tumor growth in a syngeneic mouse bladder cancer model	19
MicroRNA-499 serves as a sensitizer for lung cancer cells to radiotherapy by inhibition of CK2α-mediated phosphorylation of p65	19
Mechanisms of drug resistance in breast cancer liver metastases: Dilemmas and opportunities	19
A synDNA vaccine delivering neoAg collections controls heterogenous, multifocal murine lung and ovarian tumors via robust T cell generation	19
An epitope encoded by uORF of RNF10 elicits a therapeutic anti-tumor immune response	18
Purple sweet potato delphinidin-3-rutin represses glioma proliferation by inducing miR-20b-5p/Atg7-dependent cytostatic autophagy	18
Highly efficient PD-1-targeted CRISPR-Cas9 for tumor-infiltrating lymphocyte-based adoptive T cell therapy	18
Optimized NGFR-derived hinges for rapid and efficient enrichment and detection of CAR T cells in vitro and in vivo	18
Advancing together and moving forward: Combination gene and cellular immunotherapies	18
Exosome-mediated transfer of MIF confers temozolomide resistance by regulating TIMP3/PI3K/AKT axis in gliomas	18
A novel PD-L1-targeted shark VNAR single-domain-based CAR-T cell strategy for treating breast cancer and liver cancer	18
DNA immunotherapy targeting BARF1 induces potent anti-tumor responses against Epstein-Barr-virus-associated carcinomas	18