OOIR: Observatory of International Research

Papers

(The TQCC of Molecular Therapy-Oncolytics is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
CAR T cell therapy and the tumor microenvironment: Current challenges and opportunities	98
Regulation of Glycolysis by Non-coding RNAs in Cancer: Switching on the Warburg Effect	93
Targeting YTHDF1 effectively re-sensitizes cisplatin-resistant colon cancer cells by modulating GLS-mediated glutamine metabolism	89
Long non-coding RNAs: Biogenesis, functions, and clinical significance in gastric cancer	77
ENO1 and Cancer	76
Molecular profiles of small cell lung cancer subtypes: Therapeutic implications	70
M2 macrophage-derived exosomal microRNA-155-5p promotes the immune escape of colon cancer by downregulating ZC3H12B	62
Carboranes as unique pharmacophores in antitumor medicinal chemistry	61
Characterization of the fatty acid metabolism in colorectal cancer to guide clinical therapy	60
Fascin actin-bundling protein 1 in human cancer: Promising biomarker or therapeutic target?	55
Engineered CAR-T cells targeting TAG-72 and CD47 in ovarian cancer	52
The next wave of cellular immunotherapies in pancreatic cancer	52
CircRHBDD1 augments metabolic rewiring and restricts immunotherapy efficacy via m6A modification in hepatocellular carcinoma	51
Single-cell RNA sequencing in cancer: Applications, advances, and emerging challenges	51
Mesenchymal Stem Cell-Secreted Exosome Promotes Chemoresistance in Breast Cancer via Enhancing miR-21-5p-Mediated S100A6 Expression	48
Systematic profiling of ferroptosis gene signatures predicts prognostic factors in esophageal squamous cell carcinoma	46
Valeric Acid Suppresses Liver Cancer Development by Acting as a Novel HDAC Inhibitor	45
Tumor microenvironment and immune-related therapies of head and neck squamous cell carcinoma	45
Tumor immune microenvironment-based classifications of bladder cancer for enhancing the response rate of immunotherapy	44
Oncolytic herpes virus G47Δ works synergistically with CTLA-4 inhibition via dynamic intratumoral immune modulation	44
The emerging role of off-the-shelf engineered natural killer cells in targeted cancer immunotherapy	44
Novel roles of METTL1/WDR4 in tumor via m7G methylation	42
Exosomal and intracellular miR-320b promotes lymphatic metastasis in esophageal squamous cell carcinoma	41
Secretion of bispecific protein of anti-PD-1 fused with TGF-β trap enhances antitumor efficacy of CAR-T cell therapy	41
Metformin enhances anti-cancer effects of cisplatin in meningioma through AMPK-mTOR signaling pathways	41

Prognostic and therapeutic TILs of cervical cancer—Current advances and future perspectives	39
Efficacy of cancer-specific anti-podoplanin CAR-T cells and oncolytic herpes virus G47Δ combination therapy against glioblastoma	38
Non-coding RNAs and glioblastoma: Insight into their roles in metastasis	38
Landscape and perspectives of macrophage -targeted cancer therapy in clinical trials	38
Prognostic Implication of a Metabolism-Associated Gene Signature in Lung Adenocarcinoma	36
Defueling the cancer: ATP synthase as an emerging target in cancer therapy	36
A New Tool for CRISPR-Cas13a-Based Cancer Gene Therapy	35
Inhibition of Autophagy Amplifies Baicalein-Induced Apoptosis in Human Colorectal Cancer	35
Phase I trial of oncolytic adenovirus-mediated cytotoxic and interleukin-12 gene therapy for the treatment of metastatic pancreatic cancer	35
Angiogenesis-related non-coding RNAs and gastrointestinal cancer	35
The antitumor capacity of mesothelin-CAR-T cells in targeting solid tumors in mice	35
m6A methyltransferase METTL3-mediated lncRNA FOXD2-AS1 promotes the tumorigenesis of cervical cancer	33
SNHG1 knockdown upregulates miR-376a and downregulates FOXK1/Snail axis to prevent tumor growth and metastasis in HCC	33
Regulatory role and mechanism of m6A RNA modification in human metabolic diseases	33
Inhibition of tumor invasion and metastasis by targeting TGF-β-Smad-MMP2 pathway with Asiatic acid and Naringenin	32
m6A demethylase FTO induces NELL2 expression by inhibiting E2F1 m6A modification leading to metastasis of non-small cell lung cancer	31
A novel TanCAR targeting IL13Rα2 and EphA2 for enhanced glioblastoma therapy	31
BRD4: An emerging prospective therapeutic target in glioma	31
Genetic variants in m6A modification core genes are associated with glioma risk in Chinese children	30
microRNA-130b-3p contained in MSC-derived EVs promotes lung cancer progression by regulating the FOXO3/NFE2L2/TXNRD1 axis	30
Annexin A8 regulated by lncRNA-TUG1/miR-140-3p axis promotes bladder cancer progression and metastasis	30
Exosome-mediated transfer of MIF confers temozolomide resistance by regulating TIMP3/PI3K/AKT axis in gliomas	29
Characterization of a novel OX40 ligand and CD40 ligand-expressing oncolytic adenovirus used in the PeptiCRAd cancer vaccine platform	29
MMP25-AS1/hsa-miR-10a-5p/SERPINE1 axis as a novel prognostic biomarker associated with immune cell infiltration in KIRC	28
Exosomal circSHKBP1 participates in non-small cell lung cancer progression through PKM2-mediated glycolysis	28
Systematic review of the immunological landscape of Wilms tumors	28
Natural killer cells and immune-checkpoint inhibitor therapy: Current knowledge and new challenges	28
Classification of pediatric gliomas based on immunological profiling: Implications for immunotherapy strategies	27
Single-cell RNA-sequencing analyses identify heterogeneity of CD8+ T cell subpopulations and novel therapy targets in melanoma	27
Scutellarin resensitizes oxaliplatin-resistant colorectal cancer cells to oxaliplatin treatment through inhibition of PKM2	27
Targeting EGFR sensitizes 5-Fu-resistant colon cancer cells through modification of the lncRNA-FGD5-AS1-miR-330-3p-Hexokinase 2 axis	27
Highly efficient PD-1-targeted CRISPR-Cas9 for tumor-infiltrating lymphocyte-based adoptive T cell therapy	26
Systemic delivery of TNF-armed myxoma virus plus immune checkpoint inhibitor eliminates lung metastatic mouse osteosarcoma	25
Association of IDH mutation and 1p19q co-deletion with tumor immune microenvironment in lower-grade glioma	25
Advances and new frontiers for immunotherapy in colorectal cancer: Setting the stage for neoadjuvant success?	25
Addition of BTK inhibitor orelabrutinib to rituximab improved anti-tumor effects in B cell lymphoma	25
Systemic immunity upon local oncolytic virotherapy armed with immunostimulatory genes may be supported by tumor-derived exosomes	25
lncRNA DUXAP8 Facilitates Multiple Malignant Phenotypes and Resistance to PARP Inhibitor in HCC via Upregulating FOXM1	24
Oncolytic virus-mediated p53 overexpression promotes immunogenic cell death and efficacy of PD-1 blockade in pancreatic cancer	24
Exosomal miR-205-5p enhances angiogenesis and nasopharyngeal carcinoma metastasis by targeting desmocollin-2	24
Adoptive T cell immunotherapy for medullary thyroid carcinoma targeting GDNF family receptor alpha 4	24
The lncRNA DLGAP1-AS1/miR-149-5p/TGFB2 axis contributes to colorectal cancer progression and 5-FU resistance by regulating smad2 pathway	23
Retargeted and Multi-cytokine-Armed Herpes Virus Is a Potent Cancer Endovaccine for Local and Systemic Anti-tumor Treatment	23
Antitumor Activity In Vivo and Vitro of New Chiral Derivatives of Baicalin and Induced Apoptosis via the PI3K/Akt Signaling Pathway	22
Imaging CAR T-cell kinetics in solid tumors: Translational implications	22
Characterization of hypoxia response patterns identified prognosis and immunotherapy response in bladder cancer	22
The long non-coding RNA SNHG4/microRNA-let-7e/KDM3A/p21 pathway is involved in the development of non-small cell lung cancer	22
Current strategies in engaging oncolytic viruses with antitumor immunity	22
Oncolytic Zika virus promotes intratumoral T cell infiltration and improves immunotherapy efficacy in glioblastoma	22
A novel PD-L1-targeted shark VNAR single-domain-based CAR-T cell strategy for treating breast cancer and liver cancer	21

Breast cancer tumor microenvironment affects Treg/IL-17-producing Treg/Th17 cell axis: Molecular and therapeutic perspectives	21
Fluorescent imaging for cancer therapy and cancer gene therapy	21
AXL receptor is required for Zika virus strain MR-766 infection in human glioblastoma cell lines	21
LRPPRC regulates metastasis and glycolysis by modulating autophagy and the ROS/HIF1-α pathway in retinoblastoma	21
Tumor-derived exosomal microRNA-7-5p enhanced by verbascoside inhibits biological behaviors of glioblastoma in vitro and in vivo	20
A PD1 targeted nano-delivery system based on epigenetic alterations of T cell responses in the treatment of gastric cancer	20
lncRNA SNHG26 promoted the growth, metastasis, and cisplatin resistance of tongue squamous cell carcinoma through PGK1/Akt/mTOR signal pathway	20
Metformin inhibits gastric cancer cell proliferation by regulation of a novel Loc100506691-CHAC1 axis	20
Oncolytic reovirus-mediated recruitment of early innate immune responses reverses immunotherapy resistance in prostate tumors	20
Progress and application of circulating tumor cells in non-small cell lung cancer	20
CXCR5 guides migration and tumor eradication of anti-EGFR chimeric antigen receptor T cells	20
A brief review of reporter gene imaging in oncolytic virotherapy and gene therapy	20
Efficacy and safety of a third-generation oncolytic herpes virus G47Δ in models of human esophageal carcinoma	20
Intraperitoneal oncolytic virotherapy for patients with malignant ascites: Characterization of clinical efficacy and antitumor immune response	20
METTL3 increases cisplatin chemosensitivity of cervical cancer cells via downregulation of the activity of RAGE	19
The role of long non-coding RNAs in the pathogenesis of head and neck squamous cell carcinoma	19
miR-19a/b promote EMT and proliferation in glioma cells via SEPT7-AKT-NF-κB pathway	19
USMB-shMincle: a virus-free gene therapy for blocking M1/M2 polarization of tumor-associated macrophages	19
Circular RNAs act as regulators of autophagy in cancer	19
IFN-I-tolerant oncolytic Semliki Forest virus in combination with anti-PD1 enhances T cell response against mouse glioma	19
Extending traditional antibody therapies: Novel discoveries in immunotherapy and clinical applications	19
CRISPR-Cas knockout of miR21 reduces glioma growth	19
Transcriptional landscape associated with TNBC resistance to neoadjuvant chemotherapy revealed by single-cell RNA-seq	19
lncRNA MIR503HG inhibits cell proliferation and promotes apoptosis in TNBC cells via the miR-224-5p/HOXA9 axis	18
Preclinical Evaluation of the Oncolytic Vaccinia Virus TG6002 by Translational Research on Canine Breast Cancer	18
Circular RNA circRAB31 acts as a miR-885-5p sponge to suppress gastric cancer progression via the PTEN/PI3K/AKT pathway	18
Efficient antitumor effects of a novel oncolytic adenovirus fully composed of species B adenovirus serotype 35	18
Anti-CAIX BBζ CAR4/8 T cells exhibit superior efficacy in a ccRCC mouse model	18
Development of non-viral, ligand-dependent, EPHB4-specific chimeric antigen receptor T cells for treatment of rhabdomyosarcoma	18
Integrated analysis reveals the molecular features of fibrosis in triple-negative breast cancer	18
Therapeutic potential of IBP as an autophagy inducer for treating lung cancer via blocking PAK1/Akt/mTOR signaling	17
CCL18 promotes breast cancer progression by exosomal miR-760 activation of ARF6/Src/PI3K/Akt pathway	17
Quantitative proteomics characterization of cancer biomarkers and treatment	17
Superior infectivity of the fiber chimeric oncolytic adenoviruses Ad5/35 and Ad5/3 over Ad5-delta-24-RGD in primary glioma cultures	17
miR-15a and miR-15b modulate natural killer and CD8+T-cell activation and anti-tumor immune response by targeting PD-L1 in neuroblastoma	17
Combining vanadyl sulfate with Newcastle disease virus potentiates rapid innate immune-mediated regression with curative potential in murine cancer models	17
Noncoding RNA-mediated macrophage and cancer cell crosstalk in hepatocellular carcinoma	17
Improving the Efficacy of EGFR Inhibitors by Topical Treatment of Cutaneous Squamous Cell Carcinoma with miR-634 Ointment	17
Combination microRNA-based cellular reprogramming with paclitaxel enhances therapeutic efficacy in a relapsed and multidrug-resistant model of epithelial ovarian cancer	16
Intracranial delivery of synthetic mRNA to suppress glioblastoma	16
Upregulated CBX8 Promotes Cancer Metastasis via the WNK2/MMP2 Pathway	16
Recombinant SLAMblind Measles Virus Is a Promising Candidate for Nectin-4-Positive Triple Negative Breast Cancer Therapy	16
CD47-targeted cancer immunogene therapy: Secreted SIRPα-Fc fusion protein eradicates tumors by macrophage and NK cell activation	16
Applications of nuclear-based imaging in gene and cell therapy: Probe considerations	16
Poly(beta-amino ester) nanoparticles enable tumor-specific TRAIL secretion and a bystander effect to treat liver cancer	16
Circular RNA SERPINE2 promotes development of glioblastoma by regulating the miR-361-3p/miR-324-5p/BCL2 signaling pathway	16
MicroRNA-sensitive oncolytic measles virus for chemovirotherapy of pancreatic cancer	16