Molecular Therapy-Oncolytics

Article	Citations
Metabolic remodeling in tumor-associated macrophages contributing to antitumor activity of cryptotanshinone by regulating TRAF6-ASK1 axis	139
Sperm protein 17 targeting for epithelial ovarian cancer treatment in the era of modern immunoengineering	107
Promoting role of pentraxin-3 in esophageal squamous cell carcinoma	107
The emerging role of off-the-shelf engineered natural killer cells in targeted cancer immunotherapy	76
Ferroptosis gene signature in cholangiocarcinoma	67
Deletion of immunomodulatory genes as a novel approach to oncolytic vaccinia virus development	63
esRAGE-expressing oHSV enhances anti-tumor efficacy by inhibition of endothelial cell activation	61
Efficacy of a third-generation oncolytic herpes simplex virus in refractory soft tissue sarcoma xenograft models	55
Lazertinib improves the efficacy of chemotherapeutic drugs in ABCB1 or ABCG2 overexpression cancer cells in vitro, in vivo, and ex vivo	50
Spatiotemporal analysis of induced neural stem cell therapy to overcome advanced glioblastoma recurrence	50
Targeting carcinoembryonic antigen-expressing tumors using a novel transcriptional and translational dual-regulated oncolytic herpes simplex virus type 1	50
SNHG1 knockdown upregulates miR-376a and downregulates FOXK1/Snail axis to prevent tumor growth and metastasis in HCC	49
Systematic profiling of ferroptosis gene signatures predicts prognostic factors in esophageal squamous cell carcinoma	47
Polymer stealthing and mucin-1 retargeting for enhanced pharmacokinetics of an oncolytic vaccinia virus	46
A novel anti-B7-H3 chimeric antigen receptor from a single-chain antibody library for immunotherapy of solid cancers	45
Synthetic mRNA-based gene therapy for glioblastoma: TRAIL-mRNA synergistically enhances PTEN-mRNA-based therapy	44
Transcriptional landscape associated with TNBC resistance to neoadjuvant chemotherapy revealed by single-cell RNA-seq	43
Reinvigoration of innate and adaptive immunity via therapeutic cellular vaccine for patients with AML	43
Efficacy of cancer-specific anti-podoplanin CAR-T cells and oncolytic herpes virus G47Δ combination therapy against glioblastoma	40
A New Tool for CRISPR-Cas13a-Based Cancer Gene Therapy	39
Oncolytic herpes simplex virus armed with a bacterial GBP1 degrader improves antitumor activity	38
Anti-CAIX BBζ CAR4/8 T cells exhibit superior efficacy in a ccRCC mouse model	38
Circular RNA circLAMA3 inhibits the proliferation of bladder cancer by directly binding an mRNA	37
miR-519d-3p suppresses tumorigenicity and metastasis by inhibiting Bcl-w and HIF-1α in NSCLC	37
lncRNA RP11-147L13.8 suppresses metastasis and chemo-resistance by modulating the phosphorylation of c-Jun protein in GBC	37

The miR-23a/27a/24-2 cluster promotes postoperative progression of early-stage non-small cell lung cancer	37
Cancer stem/progenitor signatures refine the classification of clear cell renal cell carcinoma with stratified prognosis and decreased immunotherapy efficacy	37
Association of IDH mutation and 1p19q co-deletion with tumor immune microenvironment in lower-grade glioma	36
Circular RNAs act as regulators of autophagy in cancer	36
PROTACs in gastrointestinal cancers	36
Knockdown of LRRN1 inhibits malignant phenotypes through the regulation of HIF-1α/Notch pathway in pancreatic ductal adenocarcinoma	36
CAFs/tumor cells co-targeting DNA vaccine in combination with low-dose gemcitabine for the treatment of Panc02 murine pancreatic cancer	33
Preclinical evaluation of a novel antibody-drug conjugate targeting DR5 for lymphoblastic leukemia therapy	33
Potential for reversing miR-634-mediated cytoprotective processes to improve efficacy of chemotherapy against oral squamous cell carcinoma	33
Oncolytic adenovirus-mediated expression of decorin facilitates CAIX-targeting CAR-T therapy against renal cell carcinoma	32
Metformin inhibits gastric cancer cell proliferation by regulation of a novel Loc100506691-CHAC1 axis	32
Durable remission related to CAR-T persistence in R/R B-ALL and long-term persistence potential of prime CAR-T	32
In vivo DNA-launched bispecific T cell engager targeting IL-13Rα2 controls tumor growth in an animal model of glioblastoma multiforme	32
miR-1207-5p suppresses laryngeal squamous cell carcinoma progression by downregulating SKA3 and inhibiting epithelial-mesenchymal transition	32
Oncolytic virotherapy with chimeric VSV-NDV synergistically supports RIG-I-dependent checkpoint inhibitor immunotherapy	32
Amplification of the CXCR3/CXCL9 axis via intratumoral electroporation of plasmid CXCL9 synergizes with plasmid IL-12 therapy to elicit robust anti-tumor immunity	30
Intraperitoneal oncolytic virotherapy for patients with malignant ascites: Characterization of clinical efficacy and antitumor immune response	29
Current development in adenoviral vectors for cancer immunotherapy	29
AAMP promotes colorectal cancer metastasis by suppressing SMURF2-mediated ubiquitination and degradation of RhoA	28
Replication-incompetent influenza A viruses armed with IFN-γ effectively mediate immune modulation and tumor destruction in mice harboring lung cancer	28
CircRHBDD1 augments metabolic rewiring and restricts immunotherapy efficacy via m6A modification in hepatocellular carcinoma	27
MMP25-AS1/hsa-miR-10a-5p/SERPINE1 axis as a novel prognostic biomarker associated with immune cell infiltration in KIRC	26
Bispecific CD33/CD123 targeted chimeric antigen receptor T cells for the treatment of acute myeloid leukemia	26
A library of cancer testis specific T cell receptors for T cell receptor gene therapy	25
The role and application of vesicles in triple-negative breast cancer: Opportunities and challenges	25
Advances and new frontiers for immunotherapy in colorectal cancer: Setting the stage for neoadjuvant success?	25
Cannabinoid receptors promote chronic intermittent hypoxia-induced breast cancer metastasis via IGF-1R/AKT/GSK-3β	25
Pan-cancer analysis reveals distinct clinical, genomic, and immunological features of the LILRB immune checkpoint family in acute myeloid leukemia	25
LINC01296 promotes neuroblastoma tumorigenesis via the NCL-SOX11 regulatory complex	24
Bacterial cancer therapy using the attenuated fowl-adapted Salmonella enterica serovar Gallinarum	24
BRD4: An emerging prospective therapeutic target in glioma	24
Radiovirotherapy at twenty	24
Nucleic acids and proteins carried by exosomes of different origins as potential biomarkers for gynecologic cancers	23
Pre-treatment with systemic agents for advanced NSCLC elicits changes in the phenotype of autologous T cell therapy products	23
circBANP promotes colorectal cancer growth and metastasis via sponging let-7d-5p to modulate HMGA1/Wnt/β-catenin signaling	23
RETRACTED: Comprehensive analysis of FKBP4/NR3C1/TMEM173 signaling pathway in triple-negative breast cancer cell and dendritic cell among tumor microenvironment	23
A PD1 targeted nano-delivery system based on epigenetic alterations of T cell responses in the treatment of gastric cancer	23
Oncolytic vaccinia virus injected intravenously sensitizes pancreatic neuroendocrine tumors and metastases to immune checkpoint blockade	23
Thank you to our 2021 reviewers	22
Oncolytic adenovirus for treatment of malignant ascites	22
Adding recombinant AAVs to the cancer therapeutics mix	22
Oncolytic Zika virus promotes intratumoral T cell infiltration and improves immunotherapy efficacy in glioblastoma	22
Human lung adenocarcinoma CD47 is upregulated by interferon-γ and promotes tumor metastasis	22
Seneca Valley virus replicons are packaged in trans and have the capacity to overcome the limitations of viral transgene expression	22
Infection of non-cancer cells: A barrier or support for oncolytic virotherapy?	21
Diversity in responses to oncolytic Lassa-vesicular stomatitis virus in patient-derived glioblastoma cells	21
Interleukin-6-controlled, mesenchymal stem cell-based sodium/iodide symporter gene therapy improves survival of glioblastoma-bearing mice	21
Oncolytic herpes virus G47Δ works synergistically with CTLA-4 inhibition via dynamic intratumoral immune modulation	20
The quest for effective immunotherapies against malignant peripheral nerve sheath tumors: Is there hope?	20
Non-coding RNAs and glioma: Focus on cancer stem cells	20

Efficacy of coxsackievirus A21 against drug-resistant neoplastic B cells	20
Ubiquitin-related molecular classification and risk stratification of hepatocellular carcinoma	20
Thank you to our 2023 reviewers	20
Vaccinia virus and peptide-receptor radiotherapy synergize to improve treatment of peritoneal carcinomatosis	20
ScRNA-seq and bulk RNA-seq reveal the characteristics of ferroptosis and establish a risk signature in cholangiocarcinoma	20
Redirecting anti-Vaccinia virus T cell immunity for cancer treatment by AAV-mediated delivery of the VV B8R gene	20
DNA-damaging cancer cells to improve virotherapy	20
Enhancing the effectiveness of γδ T cells by mRNA transfection of chimeric antigen receptors or bispecific T cell engagers	20
A new strategy for treating colorectal cancer: Regulating the influence of intestinal flora and oncolytic virus on interferon	19
An oral cancer vaccine using a Bifidobacterium vector suppresses tumor growth in a syngeneic mouse bladder cancer model	19
MicroRNA-499 serves as a sensitizer for lung cancer cells to radiotherapy by inhibition of CK2α-mediated phosphorylation of p65	19
Mechanisms of drug resistance in breast cancer liver metastases: Dilemmas and opportunities	19
A synDNA vaccine delivering neoAg collections controls heterogenous, multifocal murine lung and ovarian tumors via robust T cell generation	19
TTN-AS1 accelerates the growth and migration of nasopharyngeal carcinoma cells via targeting miR-876-5p/NETO2	19
Exosomal and intracellular miR-320b promotes lymphatic metastasis in esophageal squamous cell carcinoma	19
Multivalent in vivo delivery of DNA-encoded bispecific T cell engagers effectively controls heterogeneous GBM tumors and mitigates immune escape	19
Sodium iodide symporter-targeted gene therapy in glioblastoma	19
Oncolytic measles vaccines encoding PD-1 and PD-L1 checkpoint blocking antibodies to increase tumor-specific T cell memory	19
Targeting EGFR sensitizes 5-Fu-resistant colon cancer cells through modification of the lncRNA-FGD5-AS1-miR-330-3p-Hexokinase 2 axis	19
Optimized NGFR-derived hinges for rapid and efficient enrichment and detection of CAR T cells in vitro and in vivo	18
Advancing together and moving forward: Combination gene and cellular immunotherapies	18
Exosome-mediated transfer of MIF confers temozolomide resistance by regulating TIMP3/PI3K/AKT axis in gliomas	18
A novel PD-L1-targeted shark VNAR single-domain-based CAR-T cell strategy for treating breast cancer and liver cancer	18
DNA immunotherapy targeting BARF1 induces potent anti-tumor responses against Epstein-Barr-virus-associated carcinomas	18
An epitope encoded by uORF of RNF10 elicits a therapeutic anti-tumor immune response	18
Purple sweet potato delphinidin-3-rutin represses glioma proliferation by inducing miR-20b-5p/Atg7-dependent cytostatic autophagy	18
Highly efficient PD-1-targeted CRISPR-Cas9 for tumor-infiltrating lymphocyte-based adoptive T cell therapy	18
Exploring the potential of eRNAs in cancer immunotherapy	17
A cross-reactive pH-dependent EGFR antibody with improved tumor selectivity and penetration obtained by structure-guided engineering	17
Gaining insights into virotherapy with canine models	17
Activation of interferon regulatory factor 3 by replication-competent vaccinia viruses improves antitumor efficacy mediated by T cell responses	17
Therapeutic potential of gene therapy for gastrointestinal diseases: Advancements and future perspectives	17
Comprehensive landscape of tRNA-derived fragments in lung cancer	17
Anti-CD117 CAR T cells incorporating a safety switch eradicate human acute myeloid leukemia and hematopoietic stem cells	17
Oncolytic virus-driven immune remodeling revealed in mouse medulloblastomas at single cell resolution	17
Systematic review of the immunological landscape of Wilms tumors	17
Targeting mesothelin in cancer	17
Advancements in CRISPR screens for the development of cancer immunotherapy strategies	16
Allogeneic tumor cell-derived extracellular vesicles stimulate CD8 T cell response in colorectal cancer	16
Combined BRM270 and endostatin inhibit relapse of NSCLC while suppressing lung cancer stem cell proliferation induced by endostatin	16
The complex relationship between integrins and oncolytic herpes Simplex Virus 1 in high-grade glioma therapeutics	16
Tagmentation-based analysis reveals the clonal behavior of CAR-T cells in association with lentivector integration sites	16
A novel chemical attack on Notch-mediated transcription by targeting the NACK ATPase	16
Cross-study safety analysis of risk factors in CAR T cell clinical trials: An FDA database pilot project	16
Development of STEAP1 targeting chimeric antigen receptor for adoptive cell therapy against cancer	15
Immunotherapy by mesenchymal stromal cell delivery of oncolytic viruses for treating metastatic tumors	15
Landscape and perspectives of macrophage -targeted cancer therapy in clinical trials	15
AXL receptor is required for Zika virus strain MR-766 infection in human glioblastoma cell lines	15
Genomic instability in lower-grade glioma: Prediction of prognosis based on lncRNA and immune infiltration	15
Expanding the landscape of TCR gene therapy targeting MAGE	14
Non-coding RNAs and glioblastoma: Insight into their roles in metastasis	14
Retraction Notice to: miR-140-3p Inhibits Cutaneous Melanoma Progression by Disrupting AKT/p70S6K and JNK Pathways through ABHD2	14
Novel roles of METTL1/WDR4 in tumor via m7G methylation	14
Poly(beta-amino ester) nanoparticles enable tumor-specific TRAIL secretion and a bystander effect to treat liver cancer	14
Improved lentiviral vector titers from a multi-gene knockout packaging line	14
Claudin18.2 bispecific T cell engager armed oncolytic virus enhances antitumor effects against pancreatic cancer	14
NEBL and AKT1 maybe new targets to eliminate the colorectal cancer cells resistance to oncolytic effect of vesicular stomatitis virus M-protein	14
A cancer cell membrane coated, doxorubicin and microRNA co-encapsulated nanoplatform for colorectal cancer theranostics	14
miR-146a inhibits ovarian tumor growth in vivo via targeting immunosuppressive neutrophils and enhancing CD8+ T cell infiltration	14
Combination of a STAT3 inhibitor with anti-PD-1 immunotherapy is an effective treatment regimen for a vemurafenib-resistant melanoma	14
Extracellular vesicle contents as non-invasive biomarkers in ovarian malignancies	13
lncRNA MIR503HG inhibits cell proliferation and promotes apoptosis in TNBC cells via the miR-224-5p/HOXA9 axis	13
Quantitative proteomics characterization of cancer biomarkers and treatment	13
The next wave of cellular immunotherapies in pancreatic cancer	13
Metformin preferentially enhances the radio-sensitivity of cancer stem-like cells with highly mitochondrial respiration ability in HMPOS	13
Novel two-chain structure utilizing KIRS2/DAP12 domain improves the safety and efficacy of CAR-T cells in adults with r/r B-ALL	13
Icaritin inhibits PLK1 to activate DNA damage response in NK/T cell lymphoma and increases sensitivity to GELOX regime	13
PBX3-activated DLG1-AS1 can promote the proliferation, invasion, and migration of TNBC cells by sponging miR-16-5p	13
PTEN potentiation of oncolytic HSV therapy for glioblastoma	13
LncRNA CBR3-AS1 promotes osteosarcoma progression through the network of miR-140-5p/DDX54-NUCKS1-mTOR signaling pathway	12
Attack of the clones: An NK cell origins story	12
CRISPR-Cas knockout of miR21 reduces glioma growth	12
Carboranes as unique pharmacophores in antitumor medicinal chemistry	12
A library of cancer testis specific T cell receptors for T cell receptor gene therapy	12
Development of a low-seroprevalence, αvβ6 integrin-selective virotherapy based on human adenovirus type 10	12
Cardamonin suppresses pro-tumor function of macrophages by decreasing M2 polarization on ovarian cancer cells via mTOR inhibition	12
Fluorescent imaging for cancer therapy and cancer gene therapy	12
Acquired chemoresistance can lead to increased resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus	12
Gene knock-out chain reaction enables high disruption efficiency of HPV18 E6/E7 genes in cervical cancer cells	12
Potent anti-tumor effects of receptor-retargeted syncytial oncolytic herpes simplex virus	12

E26 transformation-specific variant 4 as a tumor promotor in human cancers through specific molecular mechanisms	12
Scutellarin resensitizes oxaliplatin-resistant colorectal cancer cells to oxaliplatin treatment through inhibition of PKM2	12
Efficient delivery of oncolytic enterovirus by carrier cell line NK-92	12
CD133 mRNA-transfected dendritic cells induce coordinated cytotoxic and helper T cell responses against breast cancer stem cells	12
Oncolytic viruses: Narcissistic or altruistic arsonists?	12
Exosomal circSHKBP1 participates in non-small cell lung cancer progression through PKM2-mediated glycolysis	12
Development of a bicistronic anti-CD19/CD20 CAR construct including abrogation of unexpected nucleic acid sequence deletions	12
Stabilization of DEPTOR sensitizes hypopharyngeal cancer to radiotherapy via targeting degradation	12
Immune priming using DC- and T cell-targeting gene therapy sensitizes both treated and distant B16 tumors to checkpoint inhibition	11
lncRNA DSCR8 mediates miR-137/Cdc42 to regulate gastric cancer cell proliferation, invasion, and cell cycle as a competitive endogenous RNA	11
Oncolytic adenovirus inhibits malignant ascites of advanced ovarian cancer by reprogramming the ascitic immune microenvironment	11
Overcoming resistance of stroma-rich pancreatic cancer with focal adhesion kinase inhibitor combined with G47Δ and immune checkpoint inhibitors	11
Prognostic value of metabolic signature on 18F-FDG uptake in breast cancer patients after radiotherapy	11
A gene expression-based immune content predictor for survival and postoperative radiotherapy response in head and neck cancer	11
A novel fusion protein scaffold 18/12/TxM activates the IL-12, IL-15, and IL-18 receptors to induce human memory-like natural killer cells	11
An effective therapeutic regime for treatment of glioma using oncolytic vaccinia virus expressing IL-21 in combination with immune checkpoint inhibition	11
CD3 engagement as a new strategy for allogeneic “off-the-shelf” T cell therapy	11
Dual targeting of EZH1 and EZH2 for the treatment of malignant rhabdoid tumors	11
Development and comparison of 68Ga/18F/64Cu-labeled nanobody tracers probing Claudin18.2	11
Berberine inhibits carcinogenesis through antagonizing the ATX-LPA-LPAR2-p38-leptin axis in a mouse hepatoma model	10
CAR T cell therapy and the tumor microenvironment: Current challenges and opportunities	10
Anti-tumor immunity enhancement by photodynamic therapy with talaporfin sodium and anti-programmed death 1 antibody	10
Long non-coding RNAs and circular RNAs in tumor angiogenesis: From mechanisms to clinical significance	10
Progress and application of circulating tumor cells in non-small cell lung cancer	10
Local adenoviral delivery of soluble CD200R-Ig enhances antitumor immunity by inhibiting CD200-β-catenin-driven M2 macrophage	10
lncRNA SNHG26 promoted the growth, metastasis, and cisplatin resistance of tongue squamous cell carcinoma through PGK1/Akt/mTOR signal pathway	10
NAD+ depletion enhances reovirus-induced oncolysis in multiple myeloma	10
PI3K-activated MSC proteomes inhibit mammary tumors via Hsp90ab1 and Myh9	10
Combination microRNA-based cellular reprogramming with paclitaxel enhances therapeutic efficacy in a relapsed and multidrug-resistant model of epithelial ovarian cancer	10
Concurrent expression of HP-NAP enhances antitumor efficacy of oncolytic vaccinia virus but not for Semliki Forest virus	10
Dual-targeting vaccine of FGL1/CAIX exhibits potent anti-tumor activity by activating DC-mediated multi-functional CD8 T cell immunity	10
Oncolytic herpes virus G47Δ injected into tongue cancer swiftly traffics in lymphatics and suppresses metastasis	10
Breast cancer tumor microenvironment affects Treg/IL-17-producing Treg/Th17 cell axis: Molecular and therapeutic perspectives	10
A host non-coding RNA, nc886, plays a pro-viral role by promoting virus trafficking to the nucleus	9
Oncogenic lncRNA BBOX1-AS1 promotes PHF8-mediated autophagy and elicits sorafenib resistance in hepatocellular carcinoma	9
Dynamic fine-tuning of CAR-T cell therapy	9
CD47-targeted optical molecular imaging and near-infrared photoimmunotherapy in the detection and treatment of bladder cancer	9
Silencing ZIC2 abrogates tumorigenesis and anoikis resistance of non-small cell lung cancer cells by inhibiting Src/FAK signaling	9
TRIM22 orchestrates the proliferation of GBMs and the benefits of TMZ by coordinating the modification and degradation of RIG-I	9
Therapeutic effects of TM4SF5-targeting chimeric and humanized monoclonal antibodies in hepatocellular and colon cancer models	9
MicroRNA-detargeting proves more effective than leader gene deletion for improving safety of oncolytic Mengovirus in a nude mouse model	9
Oncolytic virotherapy targeting the IL15 pathway	9
β2-Adrenergic receptor agonist enhances the bystander effect of HSV-TK/GCV gene therapy in glioblastoma multiforme via upregulation of connexin 43 expression	9
Oncolytic virotherapy with intratumoral injection of vaccinia virus TG6002 and 5-fluorocytosine administration in dogs with malignant tumors	9
Next generation oncolytic viruses expressing PADI1 and TIMP2 exhibit anti-tumor activity against melanoma in nude and humanized mouse models	9
Annexin A8 regulated by lncRNA-TUG1/miR-140-3p axis promotes bladder cancer progression and metastasis	9
LRPPRC regulates metastasis and glycolysis by modulating autophagy and the ROS/HIF1-α pathway in retinoblastoma	9
The tRNA-derived fragment signature in lung cancer	9
DAP10 integration in CAR-T cells enhances the killing of heterogeneous tumors by harnessing endogenous NKG2D	9
Treatment of glioblastoma with current oHSV variants reveals differences in efficacy and immune cell recruitment	9
Zika virus cleaves GSDMD to disseminate prognosticable and controllable oncolysis in a human glioblastoma cell model	9
MicroRNA-sensitive oncolytic measles virus for chemovirotherapy of pancreatic cancer	9
Dual EGFR- and TfR-targeted gene transfer for sodium iodide symporter gene therapy of glioblastoma	9
PET imaging and treatment of pancreatic cancer peritoneal carcinomatosis after subcutaneous intratumoral administration of a novel oncolytic virus, CF33-hNIS-antiPDL1	9
CXCR5 guides migration and tumor eradication of anti-EGFR chimeric antigen receptor T cells	9
Neoadjuvant use of oncolytic herpes virus G47Δ prevents local recurrence after insufficient resection in tongue cancer models	9
miR-146a: Overcoming coldness in ovarian cancer	9
Modulation of p53 expression in cancer-associated fibroblasts prevents peritoneal metastasis of gastric cancer	9
Targeting receptor tyrosine kinases in ovarian cancer: Genomic dysregulation, clinical evaluation of inhibitors, and potential for combinatorial therapies	9