OOIR: Observatory of International Research

Papers

(The TQCC of Advanced Therapeutics is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Fabrication and Facile Surface Derivatization of Poly(ε‐caprolactone)‐Based Wound Dressing Materials Imparting Anti‐Infective, Excessive Biofluid Drainage, and Easy‐to‐Peel Characteristics	74
Breaking Immunosuppressive Barriers by Engineered Nanoplatforms for Turning Cold Tumor to Hot	52
Gold Nanocluster Encapsulated Nanorod for Tumor Microenvironment Simultaneously Activated NIR‐II Photoacoustic/Photothermal Imaging and Cancer Therapy	51
A Systematic Approach to Analyze T Cell Migration: Application to Mouse Melanoma Tumors	38
Masthead (Adv. Therap. 8/2022)	28
	28
Pathophysiology of IBD as a Key Strategy for Polymeric Nanoparticle Development	27
Zeolitic Imidazolate Frameworks Based Anticancer Drug Delivery System Associated with Dual Action of Surface Charge and Lewis Base Ligand (Adv. Therap. 9/2024)	25
Berplatin: A Conjugate of Berberine and Cisplatin Serving as a Potent Antitumor Agent with Distinctive Tumor Cell Uptake and Minimal Side Effects	24
Magnetic‐Driven Hydrogel Spiral PVA/Fe₃O₄ Micromotors for Targeted Photothermal Therapy	23
The Implication and Application of Brain Glymphatic System in Multiple Diseases	23
Masthead (Adv. Therap. 12/2022)	23
Covalent Organic Frameworks as a Biomacromolecule Immobilization Platform for Biomedical and Related Applications	23
Biomaterial‐Facilitated Local Delivery of Stem Cell‐Derived Small Extracellular Vesicles: Perspectives in Surgical Therapy	21
Accelerating Diabetic Wound Healing by Modulating the Inflammatory Environment Using Quercetin–Rosemary Oil Lipid Nanoemulsions with Artificial Intelligence‐Based Wound Closure Analysis	20
A Novel Silver Nanoparticles‐Decorated Metal‐Organic Framework with Rapid and Sustained Antimicrobial Activity against Drug‐Resistant Candida albicans through Synergistic Chemodynamic and Sonod	18
Collagen mRNA‐LNP Accelerates Skin Wound Healing	17
Plant‐Derived Phytochemicals and Their Nanoformulations for Inducing Programed Cell Death in Cancer	17
Stable High‐Concentration Monoclonal Antibody Formulations Enabled by an Amphiphilic Copolymer Excipient	17
Recent Advances in Modified Brain‐Targeting Drug Delivery Systems for Erythropoietin	16
Functionalized Chitosan Decorated Hafnium Oxide@Gold Core–Shell Nanoparticles for Multimodal Cancer Therapy	16
In Vivo Combined Photoacoustic Imaging and Photothermal Treatment of HPV‐Negative Head and Neck Carcinoma with NIR‐Responsive Non‐Persistent Plasmon Nano‐Architectures	16
Plasmon‐Enhanced Photocatalytic Activity of Organic Heterostructure for Indoor‐Light Antibacterial Therapy	16
Nanostructured Hybrid Polymer‐Lipid Drug Delivery Platforms for Rapamycin Repositioning in Anticancer Therapy	16
Identification of an ALK‐2 Inhibitor as an Agonist for Intercellular Exchange and Tumor Delivery of Nanomaterial	15

Latest Progress on Tuberculosis and HIV Co‐Infection: A Closer Look at People of Different Ages	15
	15
Inhalational Delivery of β‐glucan‐chitosan‐poly(lactic co‐glycolic) acid Nanoparticles Enhance Alveolar Macrophage Rifampin Concentrations for the Treatment of Tuberculosis	15
An Injectable Sustained Release Hydrogel of Hyaluronic Acid Loaded with β‐Ecdysterone Ameliorates Cartilage Damage in Osteoarthritis via Activating Autophagy	15
A Comparative Study of Therapeutic Effects of Mannose and Umbilical Cord Mesenchymal Stem Cells in the Treatment of Late‐Stage Diabetes	15
Issue Information (Adv. Therap. 5/2024)	15
Porous Silicon Microparticles Enable Sustained Release of GLP‐1R Agonist Peptides for the Treatment of Type 2 Diabetes	14
Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration	14
Non‐Viral Manufacturing of Cellular Immunotherapy Using Simple Mechanical Transfection Device	14
Recent Developments in Drug Delivery for Treatment of Tuberculosis by Targeting Macrophages	14
Issue Information (Adv. Therap. 11/2025)	14
Cold Atmospheric Plasma: An Emerging Immunomodulatory Therapy	14
3D‐Cell Spotter Cooperated High‐Throughput Screening (HTS) for Estimating Targeted Drugs in Breast Cancer Cells	13
The Near‐Infrared Light Emitted by LiScO₂:Cr³⁺ Phosphor Used to Induce Gland Secretion for Sjogren's Syndrome	13
Near Infrared Antibacterial Phototherapy for Treatment of Orthopedic Infections	13
Masthead (Adv. Therap. 2/2023)	13
Correction to “Phage‐Derived Oncolytic Viruses with 3C From Seneca Valley Virus for Targeted Therapy of Cervical Cancer”	12
Antidepressant Drug Discovery and Development: Mechanism and Drug Design Based on Small Molecules	12
Polymer‐Functionalized Mitochondrial Transplantation to Plaque Macrophages as a Therapeutic Strategy Targeting Atherosclerosis (Adv. Therap. 5/2022)	12
Imaging Tumor Heterogeneity and the Variations in Nanoparticle Accumulation Using Perfluorooctyl Bromide Nanocapsule X‐Ray Computed Tomography Contrast (Adv. Therap. 8/2022)	12
A Novel In Vitro Disease Model for Systemic Sclerosis Using Polyisocyanide Hydrogels	12
	12
Effect of 3D‐Printable Anisotropic Fibrous Hydrogels on Fabricating Artificial Skeletal Muscle Constructs	12
Recent Advancements in the Early Diagnosis and Treatment of Alzheimer's Disease	11
Repurposing Sertraline for the Treatment of Colorectal Cancer by Blocking Autophagic Flux and Inhibiting Tumor Proliferation	11
Plant‐Derived Extracellular Vesicles as Potential Emerging Tools for Cancer Therapeutics	11
Issue Information (Adv. Therap. 9/2025)	11
Current Advances in Immunomodulatory Biomaterials for Cell Therapy and Tissue Engineering	11
Rapid Light Response of a Novel Bi‐Based Metal–Organic Framework for Bacterial Wound Infections Treatment	11
Clinically Relevant Metallic Nanoparticles in Tuberculosis Diagnosis and Therapy	11
Hybrid Nanoparticles Dual‐Loaded With Curcumin and Benzydamine Hydrochloride for the Treatment of Vulvovaginal Candidiasis: From Development to Biological Application In Vitro and In Vivo (Adv. Therap	11
Multifunctional Fucose‐Anthocyanin Conjugate Hydrogel for Synergistic Treatment of Inflammatory Bowel Disease by Scavenging Oxidative Stress, Modulating Gut Microbiota, and Enhancing Intestinal Barrie	11
Preclinical Toxicity Assessment of Ti‐Based MXene Nanomaterials for Advanced Theranostic Applications	11
Managing Diabetes with Hydrogel Drug Delivery	11
Near‐Infrared Light‐Activatable Bismuth‐Based Nanomaterials for Antibacterial and Antitumor Treatment	11
Elastin‐Like Polypeptides Facilitate Adeno‐Associated Virus Transduction in the Presence of Pre‐Existing Neutralizing Antibodies	10
Pyrrole–Imidazole Polyamides – A Frontrunner in Nucleic Acid‐Based Small Molecule Drugs (Adv. Therap. 7/2023)	10
Engineering Living Immunotherapeutic Agents for Improved Cancer Treatment	10
	10
Potentiation of Drug Toxicity through Virus Latency Reversal Promotes Preferential Elimination of HIV Infected Cells	10
Nanoparticle‐Mediated Tumor Microenvironment Remodeling Favors the Communication with the Immune Cells for Tumor Killing	10
Novel Delivery Systems for Oral Administration of Enfuvirtide: New Treatment Options for HIV/AIDS	10
Targeting TFAP2C/PDCD6 Pathway by lncRNA PP7080 Expedites Tumorigenesis and Contributes to an Immunosuppressive Tumor Microenvironment in Non‐Small Cell Lung Cancer	10
Nanostructured AABB Zn (II) Phthalocyanines as Photodynamic Agents for Bacterial Inactivation	10
Correction to “Fluorinated Chitosan‐Mediated Transepithelial Delivery of Intravesical Dual‐Drug Immunotherapeutic for Bladder Cancer Therapy”	9
Repurposing Tamoxifen for Tumor Microenvironment Priming and Enhanced Tumor‐Targeted Drug Delivery	9
Sustained‐Release of Antigens and CpG‐DNA using Temperature‐Responsive Biodegradable Injectable Polymers: Performance on Induction of Immune Responses	9
Nanoparticles Combining Host‐Directed Therapeutics and Antibiotics to Boost Bacterial Killing and Overall Survival of Zebrafish Embryos Infected with Mycobacterium Marinum (Adv. Therap. 4/2025)	9
Stable Biotherapeutic Penetration Screening in Critically Small Colorectal Metastatic Cancer Biopsies Allows for Oncolytic Virus‐Delivered Chemotherapeutic Response Assessment through 3D Bioprinted Or	9
Upconversion‐Based Remote Deep Brain Modulation for Therapeutic Dissection of Parkinson's Disease	9

Nanoparticle‐Mediated Delivery of Micheliolide Analogs to Eliminate Leukemic Stem Cells in the Bone Marrow (Adv. Therap. 1/2022)	9
Therapeutic Targeting of Osteosarcoma and Lung Metastases in Preclinical Models Using a CD24 Antibody‐Drug Conjugate	9
Microneedles‐Mediated Intradermal Delivery of Paclitaxel/Anti‐PD‐1 for Efficient and Safe Triple‐Negative Breast Cancer Therapy	9
Mechanical Interactions Impact the Functions of Immune Cells and Their Application in Immunoengineering	9
Exosomes Derived from miR‐195‐5p Transfected Bone Marrow Mesenchymal Stem Cells Alleviate Pelvic Floor Dysfunction in Rats	9
	9
Zeolitic Imidazolate Frameworks Based Anticancer Drug Delivery System Associated with Dual Action of Surface Charge and Lewis Base Ligand	8
Identification of Candidate Antigens and Immune Subtypes in Colon Cancer for mRNA Vaccine Development	8
Cobra Hemagglutinin and cGAMP Loaded Ace‐Dex Microparticles Provide a Broadly Active and Shelf‐Stable Influenza Vaccine Platform	8
Self‐Delivery O₂‐Ecomonizer to Reverse Antiapoptosis of Hypoxic Tumor for Enhanced Photodynamic Therapy	8
HPG‐PLGA Nanoparticles for Enhanced Baicalin Delivery in Ulcerative Colitis Treatment	8
Cocktail Polyplexes With Synchronous Flightless I siRNA and Nitric Oxide Release for Potential Chronic Wound Healing	8
Dual‐Mode Vasodilator M119 Delivery to Hair Follicle via Dissolving Microneedle for Advanced Alopecia Treatment (Adv. Therap. 8/2022)	8
MicroRNA‐Responsive DNA Dendrimer Acts as a Smart STING Signal Amplifier (Adv. Therap. 10/2023)	8
Ethosomal Nanoformulations for Combinational Photothermal Therapy of Fungal Keratitis	8
Controlled Drug Release Systems for Cerebrovascular Diseases	8
Gas‐Molecule‐Mediated Radiosensitization in Cancer Therapy	8
Targeting VEGF‐A in an Immunocompetent Orthotopic Mouse Model of Mesenchymal Glioblastoma Improves Antitumorigenicity and Decreases Proinflammatory Response in Normal Brain Tissue after Fractionated R	8
Research Progress of Extracellular Vesicles Targeted Therapy	8
Surface Charge and Nanoparticle Chromophore Coupling to Achieve Fast Exciton Quenching and Efficient Charge Separation in Photoacoustic Imaging (PAI) and Photothermal therapy (PTT)	8
Efficacy and Safety of Inosine Pranobex in COVID‐19 Patients: A Multicenter Phase 3 Randomized Double‐Blind, Placebo‐Controlled Trial	8
Integrative Network Pharmacology and Bulk RNA‐Seq Unveil Berberine's Modulation of Mitochondrial Function and Oxidative Stress via SOD2 in Experimental Models of Ovarian Cancer	8
An Overview of Advancements and Technologies in Vascularization Strategies for Tumor‐On‐A‐Chip Models	8
Albumin‐Loaded Silica Nanomaterials Functionalized with Organotin(IV) Agents: Theranostic Materials Against Triple‐Negative Breast Cancer (Adv. Therap. 10/2024)	8
Masthead (Adv. Therap. 11/2023)	8
Lycium Barbarum Polysaccharides Alleviate Hyperglycemia‐Aggravated Cerebral Ischemia/Reperfusion Injury by Up‐Regulating Wnt/β‐Catenin Signaling	8
Bioempowerment of Therapeutic Living Cells by Single‐Cell Surface Engineering (Adv. Therap. 7/2023)	7
Dimethyl Oxalylglycine Activates Tendon‐Derived Stem Cells to Promote Regeneration of Achilles Tendon Rupture in Rats via HIF‐1α	7
An Acellular Platform to Drive Urinary Bladder Tissue Regeneration	7
Synergistic Antinociceptive Interaction upon Co‐Administration of Intravenous Ketamine and Lidocaine in a Thermal and Inflammatory Pain Model in Wistar Rats	7
Cytokine Engineering Approaches for Regenerative Medicine	7
Isonimesulide and Its Carborane Analogues as Isoform‐Selective COX Inhibitors and Antitumor Agents	7
Therapeutic Potential of Inulin‐Coated MCT Microcapsules in Modulating the Gut Microbiome for Effective Treatment of Diet‐Induced Obesity	7
Charging Ahead: Examining the Future Therapeutic Potential of Electroceuticals (Adv. Therap. 7/2024)	7
Genetically Engineered Membrane‐Coated Nanoparticles as Versatile Platforms with Reduced Protein Corona for Targeted siRNA Delivery	7
DNA‐Based Nanocarriers to Sequester Altered microRNAs in Cardiac Dysfunction	7
Oxygen Self‐Supplying Enzymatic Nanoplatform for Precise and Enhanced Photodynamic Therapy	7
Superior Effectiveness of PD‐1 Inhibitor Plus Chemotherapy versus Bevacizumab Plus Chemotherapy as First‐Line Treatment for Non‐Small Cell Lung Cancer with Brain Metastases	7
Masthead (Adv. Therap. 4/2023)	7
Dimethyl Fumarate Ameliorates the Endometriosis Through Anti‐Inflammatory and Anti‐Proliferation Mechanisms In Vitro and In Vivo	7
Sex Differences in Doxorubicin‐Induced Cardiotoxicity: Insights from Transcriptome Analysis	7
Topology and Mechanism of Broadband and Fast Multi‐Characteristic Opsin for Neuromodulation	7
Differentiate Thermal Property of Mammary Glands for Precise Photothermal Therapy	7
Nanoparticles in Allergen‐Delivery Systems for Allergen‐Specific Immunotherapy	7
Unleashing the Potential of Cubosomes to Overcome Ocular Barriers in Precision Drug Delivery	7
Applications of Nanomaterial‐Microorganism Hybrid Systems in the Treatment of Tumor	7
Closed‐Loop Temperature‐Controlled Magnetic Hyperthermia Therapy with Magnetic Guidance of Superparamagnetic Iron‐Oxide Nanoparticles	7
Issue Information (Adv. Therap. 5/2025)	6
Targeted and Infarcted Microenvironment‐Responsive Peptide Therapeutics to Reverse Cardiac Remodeling	6
Multifunctional Alendronate‐PEI Carbon Dots for the Treatment of Bone‐Destructive Diseases via Bidirectional Regulation of Osteoblast‐Osteoclast Function	6
Oncolytic Viruses in Cancer Immunotherapy	6
Novel Therapeutic Strategy for Bacteria‐Contaminated Bone Defects: Reconstruction with Multi‐Biofunctional GO/Cu‐Incorporated 3D Scaffolds	6
Selenadiazolesbenzothiadiazole‐Based Small Donor–Acceptor–Donor Dye for Photothermal Therapy in NIR‐II Window	6
A Single‐Dose Qβ VLP Vaccine against S100A9 Protein Reduces Atherosclerosis in a Preclinical Model	6
Hybrid Nanoparticles Dual‐Loaded With Curcumin and Benzydamine Hydrochloride for the Treatment of Vulvovaginal Candidiasis: From Development to Biological Application In Vitro and In Vivo	6
A Versatile Nanoemulsion of Antibiotic and Eucalyptol with Synergistic Effects Against E. Coli Infected Urocystitis	6
Therapeutic Potential of Mesenchymal Stem Cell‐Derived Conditioned Medium for Diabetes Mellitus and Related Complications	6
ROS‐Activatable Prodrug of Doxazolidine as Novel Cancer Therapy Paradigm	6
The Role of Extracellular Vesicles in Tumor Therapy and Imaging	6
	6
The Regulatory Roles of Mitochondrial Metabolism Dynamics and Mitochondria Calcium Uniporter (MCU) in Bevacizumab Resistance of GBM	6
Parkinson's Disease: Current Status, Diagnosis, and Treatment Using Nanomedicines	6
MicroRNA‐Responsive DNA Dendrimer Acts as a Smart STING Signal Amplifier	6
	6
Utilization of Nanoparticles, Nanodevices, and Nanotechnology in the Treatment Course of Cutaneous Melanoma	6
Antioxidant Theranostic Copolymer‐Mediated Reduction in Oxidative Stress Following Traumatic Brain Injury Improves Outcome in a Mouse Model	6
Radiation Skin Injury Care in Radiotherapy for Oncology: Mechanisms, Drug Therapy and Novel Biomaterial Application Strategies	6
In Vivo Combined Photoacoustic Imaging and Photothermal Treatment of HPV‐Negative Head and Neck Carcinoma with NIR‐Responsive Non‐Persistent Plasmon Nano‐Architectures (Adv. Therap. 10/2024)	6
Applications and Developments of Gene Therapy Drug Delivery Systems for Neurological Disorders	6
Nanoconjugate Improves Cognitive Deficit and Limits the Pathogenic Tau Burden in Okadaic‐Acid‐Induced Alzheimer's Mice	6
Issue Information (Adv. Therap. 4/2025)	6
Enhanced Anti‐Photoaging Effects of Adipose‐Derived Stem Cell (ADSC) Secretome via Liposomal and Iontophoretic Intradermal Delivery	6
Combination Drug Therapy of Glioblastoma: Lessons from 3D In Vitro Models and the Roadmap for Future Research	6
Enhanced Anticancer Effects of Intratumorally Injected Electrostatic Doxorubicin‐Loaded Click‐Type Crosslinked Hyaluronic Acid Hydrogel	6
	6
Black Phosphorus Microbubbles Combined with Ultrasound for Treating Parkinson's Disease	6
Spatiotemporal Control of IL‐12 Delivery Improves Its Efficacy in Treatment of Solid Tumors	6
Oxygen‐Generated Hierarchical‐Structured AuNRs@MnO₂@SiO₂ Nanocarrier for Enhanced NIR‐ and H₂O₂‐Responsive Mild‐Hyperthermia Photodynamic/Photothermal Combi	6
Infrared Light Activated Highly Efficient Cell Therapy Using Flower‐Shaped Microstructure Device	6
Nanoparticle and Gene Therapy Strategies for Site‐Specific Pain Management: A Review	5

Hydrogels of Alginate Derivative‐Encased Nanodots Featuring Carbon‐Coated Manganese Ferrite Cores with Gold Shells to Offer Antiangiogenesis with Multimodal Imaging‐Based Theranostics	5
Ionic Liquids: Momentous Tools in Transdermal Delivery of Biomacromolecules	5
From Challenges to Solution: The Evolving Landscape of Leprosy Management	5
Inducible Regulatory T Cell Predicts Efficacy of PD‐1 Blockade Therapy in Melanoma (Adv. Therap. 4/2022)	5
Development of a Hibernation‐Inspired Preservation Strategy to Enhance the Clinical Translation of Photosynthetic Biomaterials	5
	5
Therapeutic Effect of a Near‐Infrared Responsive MTX‐Mn₃O₄@PDA Nano‐Delivery System on Rheumatoid Arthritis	5
Development of a Clinically Viable Strategy for Nanoparticle‐Based Photodynamic Therapy of Colorectal Cancer	5
Genetic Engineering Methods in Primary T Cells	5
Nanotechnologies Targeting Traumatic Brain Injury: From Diagnosis to Targeted Therapy	5
PVA‐co‐PAMPS Membranes with Selective Anticancer Activity and Metabolic Stimulation of Healthy Cells	5
Canine Breast Carcinomas: Recent Advances in Diagnostic and Treatment Strategies	5
Recent Developments in Drug Delivery for Treatment of Tuberculosis by Targeting Macrophages (Adv. Therap. 6/2022)	5
Success in Navigating Hurdles to Oral Delivery of a Bioactive Peptide Complement Antagonist through Use of Nanoparticles to Increase Bioavailability and In Vivo Efficacy (Adv. Therap. 12/2022)	5
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Therapeutic Targeting Tongue Squamous Cell Carcinoma via ICAM1 Antibody‐Drug Conjugates in Preclinical Models	5
Fructose‐Coated Ångstrom Silver Particles Suppress Gastric Cancer Growth by Activating Gasdermin D‐Mediated Pyroptosis	5
Oral Doxorubicin Lipid Nanoparticles Enhance Triple‐Negative Breast Cancer Therapy via Immune Activation and Reduced Cardiotoxicity	5
Engineering Eutectogel Microneedle Patch as Effective Transdermal Delivery System of Hydrophobic Drugs	5
Conjugated‐Polymer‐Based Photodynamic Therapy	5
Antitumorigenic Effect of Combination Treatment with BRAF Inhibitor and Cisplatin in Colorectal Cancer In Vitro and In Vivo	5
Extracellular Vesicles in the Repair of Bone and Cartilage Injury: From Macro‐Delivery to Micro‐Modification	5
Advancement of Photobiomodulation Therapy Using 680 and 850 nm Light‐Emitting Diodes for the Differentiation of Human Brain Endothelial Cells	5
Development of a Clinically Viable Strategy for Nanoparticle‐Based Photodynamic Therapy of Colorectal Cancer (Adv. Therap. 4/2023)	5
Single‐Administration Self‐Boosting Microneedle Patch for the Treatment of Obesity	5
RNA‐Based Therapeutics: Cutting‐Edge Advances in Clinical Research	5
Does Encapsulation of π‐Conjugated Polymer Nanoparticles within Biodegradable PEG–PLGA Matrices Mitigate Photoinduced Free Radical Production and Phototoxicity?	5
Multidisciplinary Approaches in the Treatment of Retinal Degenerative Diseases: A Review	5
Double‐Layered Polyvinylpyrrolidone–Poly(methyl vinyl ether‐alt‐maleic acid)‐Based Microneedles to Deliver Meloxicam: An In Vitro, In Vivo, and Short‐Term Stability Evaluation Study	5
Particle Hydrogels Decrease Cerebral Atrophy and Attenuate Astrocyte and Microglia/Macrophage Reactivity after Stroke	5