OOIR: Observatory of International Research

Papers

(The TQCC of Advanced Therapeutics is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
A Novel Silver Nanoparticles‐Decorated Metal‐Organic Framework with Rapid and Sustained Antimicrobial Activity against Drug‐Resistant Candida albicans through Synergistic Chemodynamic and Sonod	57
Masthead (Adv. Therap. 8/2022)	43
	43
Masthead (Adv. Therap. 12/2022)	42
Breaking Immunosuppressive Barriers by Engineered Nanoplatforms for Turning Cold Tumor to Hot	42
Pathophysiology of IBD as a Key Strategy for Polymeric Nanoparticle Development	41
Berplatin: A Conjugate of Berberine and Cisplatin Serving as a Potent Antitumor Agent with Distinctive Tumor Cell Uptake and Minimal Side Effects	37
Accelerating Diabetic Wound Healing by Modulating the Inflammatory Environment Using Quercetin–Rosemary Oil Lipid Nanoemulsions with Artificial Intelligence‐Based Wound Closure Analysis	32
MRI‐Active Metal‐Organic Frameworks: Concepts for the Translation from Lab to Clinic	28
Plant‐Derived Phytochemicals and Their Nanoformulations for Inducing Programed Cell Death in Cancer	28
The Implication and Application of Brain Glymphatic System in Multiple Diseases	26
Magnetic‐Driven Hydrogel Spiral PVA/Fe₃O₄ Micromotors for Targeted Photothermal Therapy	26
Gold Nanocluster Encapsulated Nanorod for Tumor Microenvironment Simultaneously Activated NIR‐II Photoacoustic/Photothermal Imaging and Cancer Therapy	23
Biomaterial‐Facilitated Local Delivery of Stem Cell‐Derived Small Extracellular Vesicles: Perspectives in Surgical Therapy	22
Stable High‐Concentration Monoclonal Antibody Formulations Enabled by an Amphiphilic Copolymer Excipient	21
Fabrication and Facile Surface Derivatization of Poly(ε‐caprolactone)‐Based Wound Dressing Materials Imparting Anti‐Infective, Excessive Biofluid Drainage, and Easy‐to‐Peel Characteristics	21
Plasmon‐Enhanced Photocatalytic Activity of Organic Heterostructure for Indoor‐Light Antibacterial Therapy	20
	20
Covalent Organic Frameworks as a Biomacromolecule Immobilization Platform for Biomedical and Related Applications	20
Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration	20
Issue Information (Adv. Therap. 5/2024)	19
Porous Silicon Microparticles Enable Sustained Release of GLP‐1R Agonist Peptides for the Treatment of Type 2 Diabetes	18
Investigation of FcRn‐Mediated Transepithelial Mechanisms for Oral Nanoparticle Delivery Systems	18
Cold Atmospheric Plasma: An Emerging Immunomodulatory Therapy	17
In Vivo Combined Photoacoustic Imaging and Photothermal Treatment of HPV‐Negative Head and Neck Carcinoma with NIR‐Responsive Non‐Persistent Plasmon Nano‐Architectures	17

Nanostructured Hybrid Polymer‐Lipid Drug Delivery Platforms for Rapamycin Repositioning in Anticancer Therapy	17
Virus‐Mimic mRNA Vaccine for Cancer Treatment	16
Recent Advances in Modified Brain‐Targeting Drug Delivery Systems for Erythropoietin	16
Latest Progress on Tuberculosis and HIV Co‐Infection: A Closer Look at People of Different Ages	16
An Injectable Sustained Release Hydrogel of Hyaluronic Acid Loaded with β‐Ecdysterone Ameliorates Cartilage Damage in Osteoarthritis via Activating Autophagy	16
Recent Developments in Drug Delivery for Treatment of Tuberculosis by Targeting Macrophages	16
Senolysis Reduces Senescence in Veins and Cancer Cell Migration	16
Identification of an ALK‐2 Inhibitor as an Agonist for Intercellular Exchange and Tumor Delivery of Nanomaterial	15
Functionalized Chitosan Decorated Hafnium Oxide@Gold Core–Shell Nanoparticles for Multimodal Cancer Therapy	15
Inhalational Delivery of β‐glucan‐chitosan‐poly(lactic co‐glycolic) acid Nanoparticles Enhance Alveolar Macrophage Rifampin Concentrations for the Treatment of Tuberculosis	15
Preclinical Toxicity Assessment of Ti‐Based MXene Nanomaterials for Advanced Theranostic Applications	14
Polymer‐Functionalized Mitochondrial Transplantation to Plaque Macrophages as a Therapeutic Strategy Targeting Atherosclerosis (Adv. Therap. 5/2022)	14
	14
Effect of 3D‐Printable Anisotropic Fibrous Hydrogels on Fabricating Artificial Skeletal Muscle Constructs	13
Antidepressant Drug Discovery and Development: Mechanism and Drug Design Based on Small Molecules	13
A Novel In Vitro Disease Model for Systemic Sclerosis Using Polyisocyanide Hydrogels	13
A 3D‐Bioprinted Vascularized Glioblastoma‐on‐a‐Chip for Studying the Impact of Simulated Microgravity as a Novel Pre‐Clinical Approach in Brain Tumor Therapy (Adv. Therap. 11/2021)	13
Clinically Relevant Metallic Nanoparticles in Tuberculosis Diagnosis and Therapy	13
3D‐Cell Spotter Cooperated High‐Throughput Screening (HTS) for Estimating Targeted Drugs in Breast Cancer Cells	13
Imaging Tumor Heterogeneity and the Variations in Nanoparticle Accumulation Using Perfluorooctyl Bromide Nanocapsule X‐Ray Computed Tomography Contrast (Adv. Therap. 8/2022)	12
Repurposing Sertraline for the Treatment of Colorectal Cancer by Blocking Autophagic Flux and Inhibiting Tumor Proliferation	12
Masthead (Adv. Therap. 2/2023)	12
The Near‐Infrared Light Emitted by LiScO₂:Cr³⁺ Phosphor Used to Induce Gland Secretion for Sjogren's Syndrome	12
Correction to “Phage‐Derived Oncolytic Viruses with 3C From Seneca Valley Virus for Targeted Therapy of Cervical Cancer”	12
Hybrid Nanoparticles Dual‐Loaded With Curcumin and Benzydamine Hydrochloride for the Treatment of Vulvovaginal Candidiasis: From Development to Biological Application In Vitro and In Vivo (Adv. Therap	11
T Cell‐Signaling‐Responsive Conjugate of Antibody with siRNA to Overcome Acquired Resistance to anti‐PD‐1 Immunotherapy	11
Current Advances in Immunomodulatory Biomaterials for Cell Therapy and Tissue Engineering	11
Recent Advancements in the Early Diagnosis and Treatment of Alzheimer's Disease	11
Managing Diabetes with Hydrogel Drug Delivery	11
Rapid Light Response of a Novel Bi‐Based Metal–Organic Framework for Bacterial Wound Infections Treatment	11
Plant‐Derived Extracellular Vesicles as Potential Emerging Tools for Cancer Therapeutics	11
Light‐Triggered Drug Release from Red Blood Cells Suppresses Arthritic Inflammation	11
Near‐Infrared Light‐Activatable Bismuth‐Based Nanomaterials for Antibacterial and Antitumor Treatment	10
Elastin‐Like Polypeptides Facilitate Adeno‐Associated Virus Transduction in the Presence of Pre‐Existing Neutralizing Antibodies	10
Novel Delivery Systems for Oral Administration of Enfuvirtide: New Treatment Options for HIV/AIDS	10
Pyrrole–Imidazole Polyamides – A Frontrunner in Nucleic Acid‐Based Small Molecule Drugs (Adv. Therap. 7/2023)	10
Nanostructured AABB Zn (II) Phthalocyanines as Photodynamic Agents for Bacterial Inactivation	10
Recombinant Human Epidermal Growth Factor/Quatsome Nanoconjugates: A Robust Topical Delivery System for Complex Wound Healing (Adv. Therap. 6/2021)	10
Repurposing Tamoxifen for Tumor Microenvironment Priming and Enhanced Tumor‐Targeted Drug Delivery	9
Potentiation of Drug Toxicity through Virus Latency Reversal Promotes Preferential Elimination of HIV Infected Cells	9
Targeting TFAP2C/PDCD6 Pathway by lncRNA PP7080 Expedites Tumorigenesis and Contributes to an Immunosuppressive Tumor Microenvironment in Non‐Small Cell Lung Cancer	9
Microneedles‐Mediated Intradermal Delivery of Paclitaxel/Anti‐PD‐1 for Efficient and Safe Triple‐Negative Breast Cancer Therapy	9
Nanoparticle‐Mediated Tumor Microenvironment Remodeling Favors the Communication with the Immune Cells for Tumor Killing	9
Identification of Candidate Antigens and Immune Subtypes in Colon Cancer for mRNA Vaccine Development	9
Engineering Living Immunotherapeutic Agents for Improved Cancer Treatment	9
	8
Surface Charge and Nanoparticle Chromophore Coupling to Achieve Fast Exciton Quenching and Efficient Charge Separation in Photoacoustic Imaging (PAI) and Photothermal therapy (PTT)	8
	8
Cobra Hemagglutinin and cGAMP Loaded Ace‐Dex Microparticles Provide a Broadly Active and Shelf‐Stable Influenza Vaccine Platform	8
Nanoparticle‐Mediated Delivery of Micheliolide Analogs to Eliminate Leukemic Stem Cells in the Bone Marrow	8

Cocktail Polyplexes With Synchronous Flightless I siRNA and Nitric Oxide Release for Potential Chronic Wound Healing	8
Dual‐Mode Vasodilator M119 Delivery to Hair Follicle via Dissolving Microneedle for Advanced Alopecia Treatment (Adv. Therap. 8/2022)	8
Self‐Delivery O₂‐Ecomonizer to Reverse Antiapoptosis of Hypoxic Tumor for Enhanced Photodynamic Therapy	8
Controlled Drug Release Systems for Cerebrovascular Diseases	8
Sustained‐Release of Antigens and CpG‐DNA using Temperature‐Responsive Biodegradable Injectable Polymers: Performance on Induction of Immune Responses	8
MicroRNA‐Responsive DNA Dendrimer Acts as a Smart STING Signal Amplifier (Adv. Therap. 10/2023)	8
An Overview of Advancements and Technologies in Vascularization Strategies for Tumor‐On‐A‐Chip Models	8
Efficacy and Safety of Inosine Pranobex in COVID‐19 Patients: A Multicenter Phase 3 Randomized Double‐Blind, Placebo‐Controlled Trial	8
Stable Biotherapeutic Penetration Screening in Critically Small Colorectal Metastatic Cancer Biopsies Allows for Oncolytic Virus‐Delivered Chemotherapeutic Response Assessment through 3D Bioprinted Or	8
Nanoparticle‐Mediated Delivery of Micheliolide Analogs to Eliminate Leukemic Stem Cells in the Bone Marrow (Adv. Therap. 1/2022)	8
Albumin‐Loaded Silica Nanomaterials Functionalized with Organotin(IV) Agents: Theranostic Materials Against Triple‐Negative Breast Cancer (Adv. Therap. 10/2024)	8
Fluorinated Chitosan Mediated Synthesis of Copper Selenide Nanoparticles with Enhanced Penetration for Second Near‐Infrared Photothermal Therapy of Bladder Cancer	8
	8
Targeting VEGF‐A in an Immunocompetent Orthotopic Mouse Model of Mesenchymal Glioblastoma Improves Antitumorigenicity and Decreases Proinflammatory Response in Normal Brain Tissue after Fractionated R	7
Upconversion‐Based Remote Deep Brain Modulation for Therapeutic Dissection of Parkinson's Disease	7
Exosomes Derived from miR‐195‐5p Transfected Bone Marrow Mesenchymal Stem Cells Alleviate Pelvic Floor Dysfunction in Rats	7
Engineering Gene Therapy: Advances and Barriers (Adv. Therap. 9/2021)	7
Argyrin F Treatment‐Induced Vulnerabilities Lead to a Novel Combination Therapy in Experimental Glioma	7
Masthead (Adv. Therap. 11/2023)	7
Zeolitic Imidazolate Frameworks Based Anticancer Drug Delivery System Associated with Dual Action of Surface Charge and Lewis Base Ligand	7
Integrative Network Pharmacology and Bulk RNA‐Seq Unveil Berberine's Modulation of Mitochondrial Function and Oxidative Stress via SOD2 in Experimental Models of Ovarian Cancer	7
Nanoparticles Combining Host‐Directed Therapeutics and Antibiotics to Boost Bacterial Killing and Overall Survival of Zebrafish Embryos Infected with Mycobacterium Marinum (Adv. Therap. 4/2025)	7
Research Progress of Extracellular Vesicles Targeted Therapy	7
Charging Ahead: Examining the Future Therapeutic Potential of Electroceuticals (Adv. Therap. 7/2024)	7
Closed‐Loop Temperature‐Controlled Magnetic Hyperthermia Therapy with Magnetic Guidance of Superparamagnetic Iron‐Oxide Nanoparticles	7
Superior Effectiveness of PD‐1 Inhibitor Plus Chemotherapy versus Bevacizumab Plus Chemotherapy as First‐Line Treatment for Non‐Small Cell Lung Cancer with Brain Metastases	7
Differentiate Thermal Property of Mammary Glands for Precise Photothermal Therapy	7
Ethosomal Nanoformulations for Combinational Photothermal Therapy of Fungal Keratitis	7
Peptide‐Based Inhibitors for SARS‐CoV‐2 and SARS‐CoV	7
Bioempowerment of Therapeutic Living Cells by Single‐Cell Surface Engineering (Adv. Therap. 7/2023)	7
Genetically Engineered Membrane‐Coated Nanoparticles as Versatile Platforms with Reduced Protein Corona for Targeted siRNA Delivery	7
Synergistic Antinociceptive Interaction upon Co‐Administration of Intravenous Ketamine and Lidocaine in a Thermal and Inflammatory Pain Model in Wistar Rats	7
DNA‐Based Nanocarriers to Sequester Altered microRNAs in Cardiac Dysfunction	7
Utilization of Nanoparticles, Nanodevices, and Nanotechnology in the Treatment Course of Cutaneous Melanoma	6
Selenadiazolesbenzothiadiazole‐Based Small Donor–Acceptor–Donor Dye for Photothermal Therapy in NIR‐II Window	6
Enhanced Anticancer Effects of Intratumorally Injected Electrostatic Doxorubicin‐Loaded Click‐Type Crosslinked Hyaluronic Acid Hydrogel	6
Therapeutic Potential of Inulin‐Coated MCT Microcapsules in Modulating the Gut Microbiome for Effective Treatment of Diet‐Induced Obesity	6
Mn₃O₄ Nanozyme for Inflammatory Bowel Disease Therapy	6
Dimethyl Oxalylglycine Activates Tendon‐Derived Stem Cells to Promote Regeneration of Achilles Tendon Rupture in Rats via HIF‐1α	6
Sex Differences in Doxorubicin‐Induced Cardiotoxicity: Insights from Transcriptome Analysis	6
Sonoporation‐Enhanced Delivery of STING Agonist Induced Robust Immune Modulation and Tumor Regression (Adv. Therap. 10/2021)	6
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Synergistic Photothermal and Chemical Therapy by Smart Dual‐Functional Graphdiyne Nanosheets for Treatment of Parkinson's Disease (Adv. Therap. 7/2021)	6
Isonimesulide and Its Carborane Analogues as Isoform‐Selective COX Inhibitors and Antitumor Agents	6
Nanoparticles in Allergen‐Delivery Systems for Allergen‐Specific Immunotherapy	6
An Acellular Platform to Drive Urinary Bladder Tissue Regeneration	6
Black Phosphorus Microbubbles Combined with Ultrasound for Treating Parkinson's Disease	6
Hybrid Nanoparticles Dual‐Loaded With Curcumin and Benzydamine Hydrochloride for the Treatment of Vulvovaginal Candidiasis: From Development to Biological Application In Vitro and In Vivo	6
Dimethyl Fumarate Ameliorates the Endometriosis Through Anti‐Inflammatory and Anti‐Proliferation Mechanisms In Vitro and In Vivo	6
MicroRNA‐Responsive DNA Dendrimer Acts as a Smart STING Signal Amplifier	6
Masthead (Adv. Therap. 4/2023)	6
Applications of Nanomaterial‐Microorganism Hybrid Systems in the Treatment of Tumor	6
Oxygen Self‐Supplying Enzymatic Nanoplatform for Precise and Enhanced Photodynamic Therapy	6
Novel Therapeutic Strategy for Bacteria‐Contaminated Bone Defects: Reconstruction with Multi‐Biofunctional GO/Cu‐Incorporated 3D Scaffolds	6
Targeted and Infarcted Microenvironment‐Responsive Peptide Therapeutics to Reverse Cardiac Remodeling	5
Combination Drug Therapy of Glioblastoma: Lessons from 3D In Vitro Models and the Roadmap for Future Research	5
Radiation Skin Injury Care in Radiotherapy for Oncology: Mechanisms, Drug Therapy and Novel Biomaterial Application Strategies	5
Antioxidant Theranostic Copolymer‐Mediated Reduction in Oxidative Stress Following Traumatic Brain Injury Improves Outcome in a Mouse Model	5
Does Encapsulation of π‐Conjugated Polymer Nanoparticles within Biodegradable PEG–PLGA Matrices Mitigate Photoinduced Free Radical Production and Phototoxicity?	5
The Regulatory Roles of Mitochondrial Metabolism Dynamics and Mitochondria Calcium Uniporter (MCU) in Bevacizumab Resistance of GBM	5
ROS‐Activatable Prodrug of Doxazolidine as Novel Cancer Therapy Paradigm	5
In Vivo Combined Photoacoustic Imaging and Photothermal Treatment of HPV‐Negative Head and Neck Carcinoma with NIR‐Responsive Non‐Persistent Plasmon Nano‐Architectures (Adv. Therap. 10/2024)	5
A Single‐Dose Qβ VLP Vaccine against S100A9 Protein Reduces Atherosclerosis in a Preclinical Model	5
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Insulin Delivery Using Dynamic Covalent Boronic Acid/Ester‐Controlled Release	5
Development of a Hibernation‐Inspired Preservation Strategy to Enhance the Clinical Translation of Photosynthetic Biomaterials	5
Canine Breast Carcinomas: Recent Advances in Diagnostic and Treatment Strategies	5
Conjugated‐Polymer‐Based Photodynamic Therapy	5
Infrared Light Activated Highly Efficient Cell Therapy Using Flower‐Shaped Microstructure Device	5
	5
Oncolytic Viruses in Cancer Immunotherapy	5
Multifunctional Alendronate‐PEI Carbon Dots for the Treatment of Bone‐Destructive Diseases via Bidirectional Regulation of Osteoblast‐Osteoclast Function	5
A Versatile Nanoemulsion of Antibiotic and Eucalyptol with Synergistic Effects Against E. Coli Infected Urocystitis	5
The Role of Extracellular Vesicles in Tumor Therapy and Imaging	5
Oxygen‐Generated Hierarchical‐Structured AuNRs@MnO₂@SiO₂ Nanocarrier for Enhanced NIR‐ and H₂O₂‐Responsive Mild‐Hyperthermia Photodynamic/Photothermal Combi	5
Development of a Clinically Viable Strategy for Nanoparticle‐Based Photodynamic Therapy of Colorectal Cancer	5
Applications and Developments of Gene Therapy Drug Delivery Systems for Neurological Disorders	5
Clinically Translatable Formulation Strategies for Systemic Administration of Nerve‐Specific Probes	5
Nanoconjugate Improves Cognitive Deficit and Limits the Pathogenic Tau Burden in Okadaic‐Acid‐Induced Alzheimer's Mice	4
Enhanced Anti‐Photoaging Effects of Adipose‐Derived Stem Cell (ADSC) Secretome via Liposomal and Iontophoretic Intradermal Delivery	4

Ionic Liquids: Momentous Tools in Transdermal Delivery of Biomacromolecules	4
From Challenges to Solution: The Evolving Landscape of Leprosy Management	4
PLGA Nanoparticles Coated with Activated Dendritic Cell Membrane Can Prolong Protein Expression and Improve the Efficacy of mRNA	4
Low Inorganic Phosphate Stress Inhibits Liver Cancer Progression: from In Vivo to In Vitro	4
Hydrogels of Alginate Derivative‐Encased Nanodots Featuring Carbon‐Coated Manganese Ferrite Cores with Gold Shells to Offer Antiangiogenesis with Multimodal Imaging‐Based Theranostics	4
Fructose‐Coated Ångstrom Silver Particles Suppress Gastric Cancer Growth by Activating Gasdermin D‐Mediated Pyroptosis	4
Masthead (Adv. Therap. 10/2021)	4
Recent Developments in Drug Delivery for Treatment of Tuberculosis by Targeting Macrophages (Adv. Therap. 6/2022)	4
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Parkinson's Disease: Current Status, Diagnosis, and Treatment Using Nanomedicines	4
Therapeutic Potential of Mesenchymal Stem Cell‐Derived Conditioned Medium for Diabetes Mellitus and Related Complications	4
Multidisciplinary Approaches in the Treatment of Retinal Degenerative Diseases: A Review	4
Therapeutic Targeting Tongue Squamous Cell Carcinoma via ICAM1 Antibody‐Drug Conjugates in Preclinical Models	4
Masthead (Adv. Therap. 5/2021)	4
Malaria Chemotherapeutics What Next for Africa	4
Single‐Administration Self‐Boosting Microneedle Patch for the Treatment of Obesity	4
Comparison of SGLT1, SGLT2, and Dual Inhibitor Biological Activity in Treating Type 2 Diabetes Mellitus	4
Antitumorigenic Effect of Combination Treatment with BRAF Inhibitor and Cisplatin in Colorectal Cancer In Vitro and In Vivo	4
Issue Information (Adv. Therap. 4/2025)	4
Extracellular Vesicles in the Repair of Bone and Cartilage Injury: From Macro‐Delivery to Micro‐Modification	4
Success in Navigating Hurdles to Oral Delivery of a Bioactive Peptide Complement Antagonist through Use of Nanoparticles to Increase Bioavailability and In Vivo Efficacy (Adv. Therap. 12/2022)	4
Development of a Clinically Viable Strategy for Nanoparticle‐Based Photodynamic Therapy of Colorectal Cancer (Adv. Therap. 4/2023)	4
Pyrrole–Imidazole Polyamides – A Frontrunner in Nucleic Acid‐Based Small Molecule Drugs	4
RNA Encapsulation in Metal–Organic Frameworks for Targeting Cancer‐Causing Genes	4
Double‐Layered Polyvinylpyrrolidone–Poly(methyl vinyl ether‐alt‐maleic acid)‐Based Microneedles to Deliver Meloxicam: An In Vitro, In Vivo, and Short‐Term Stability Evaluation Study	4
Engineering Gene Therapy: Advances and Barriers	4
Engineered Multivalent Nanobodies Potently and Broadly Neutralize SARS‐CoV‐2 Variants	4
Inducible Regulatory T Cell Predicts Efficacy of PD‐1 Blockade Therapy in Melanoma (Adv. Therap. 4/2022)	4