Regenerative Therapy

Article	Citations
Selective effects of collagen-derived peptides Pro-Hyp and Hyp-Gly on the proliferation and differentiation of SSEA3-positive human dental pulp stem cells	112
Bridging potential of Taurine-loading PCL conduits transplanted with hEnSCs on resected sciatic nerves	73
CD73-positive pediatric urethral mesenchymal stem-like cell-derived small extracellular vesicles stimulate angiogenesis	62
Effect of silk fibroin scaffold loaded with 17-β estradiol on the proliferation and differentiation of BMSCs	60
Baseline magnetic resonance imaging findings associated with short-term clinical outcomes after intraarticular administration of autologous adipose-derived stem cells for knee osteoarthritis	55
Diverting the food-freezing technology improves the cryopreservation efficiency of induced pluripotent stem cells and derived neurospheres	53
Role of WIF-1 in regulating chondrocyte dedifferentiation and matrix production through WNT pathway	46
Research status of facial nerve repair	46
The role of telomeres in leukemic stem cells function	45
Comparative gastrointestinal organoid models across species: A Zoobiquity approach for precision medicine	45
Stress and motivation of cell processing operators: A pilot study of an online questionnaire survey	43
The potential of Spirulina maxima extract-treated conditioned medium from adipose-derived mesenchymal stem cells for hair growth promoting effect on human dermal papilla cells	43
The generation of islet-like insulin-producing cells from Wharton's jelly-derived mesenchymal stem cells on the PES/fish gelatin scaffold	42
Current and emerging therapies for knee osteoarthritis: From conventional approaches to machine learning and stem cell innovations	41
CircRNA PVT1 modulated cell migration and invasion through Epithelial-Mesenchymal Transition (EMT) mediation in gastric cancer through miR-423-5p/Smad3 pathway	39
Study on promoting the regeneration of grafted fat by cell-assisted lipotransfer	39
First-in-human study to investigate the safety and efficacy of effective-mononuclear cell therapy for radiogenic xerostomia	38
Effects of plasma rich in growth factors on wound healing in patients with venous ulcers	37
Estradiol enhanced neuronal plasticity and ameliorated astrogliosis in human iPSC-derived neural models	37
Human iPSC-derived cerebral organoids reveal oxytocin-mediated protection against amyloid-β pathology	37
BNIP3 induced by hypoxia supports the survival of mesenchymal stromal cells (MSCs) after intravenous cell transplantation	36
Adipogenesis of bioabsorbable implants under irradiation in a rodent model	35
A new clinical classification and reconstructive strategy for post-sternotomy surgical site infection	35
The research landscape and trends of dental pulp stem cell studies (2010–2025): A bibliometric analysis	33
Best evidence summary for platelet-rich plasma treatment of chronic wounds	33

Optimal dose of bone marrow mesenchymal stem cell transplantation for experimental ulcerative colitis	32
Xenogeneic mesenchymal stem cell biocurative improves skin wounds healing in diabetic mice by increasing mast cells and the regenerative profile	32
Development of pyrogen-free utensils for cell culture by combining ozone/hydrogen peroxide mixed gas sterilization with steam-washing technology	31
Prospects and challenges in NMDAR signaling in spinal cord injury recovery and neural circuit remodeling	31
Clinical challenges of short bowel syndrome and the path forward for organoid-based regenerative medicine	29
Intrauterine injection of bioengineered hydrogel loaded exosomes derived from HUCM stem cells and spermidine prominently augments the pregnancy rate in thin endometrium rats	29
Regenerative medicine strategies for hair growth and regeneration: A narrative review of literature	28
Bone morphogenetic protein-2-derived osteogenic peptide promotes bone regeneration via osteoblastogenesis	27
Tanshinone IIA protects motor neuron-like NSC-34 cells against lipopolysaccharide-induced cell injury by the regulation of the lncRNA TCTN2/miR-125a-5p/DUSP1 axis	27
Downregulation of hsa_circ_0000885 suppressed osteosarcoma metastasis and progression via regulating E2F3 expression and sponging miR-16-5p	26
Phenytoin regulates osteogenic differentiation of human bone marrow stem cells by PI3K/Akt pathway	26
Intra-articular administration of autologous adipose-derived stem cells in hip osteoarthritis: Longitudinal treatment trajectories and prognostic factors	25
RAD51 promotes osteogenic differentiation and inhibits DNA damage in osteoporosis though regulating cGAS-STING signaling pathway	25
Polydactyly bone marrow-derived mesenchymal stem cell-conditioned medium can prevent cartilage degeneration and alleviate knee pain in a rat model of osteoarthritis	25
Qianzheng powder promotes facial nerve regeneration via BDNF/TrkB/CREB pathway activation	25
Conditioned plasma promotes full-thickness skin defect healing in a rat model	25
Alkali-extracted proteins from the tooth dentin matrix as a mixture of bioactive molecules for cartilage repair and regeneration	24
Characterization of dynamical changes in vital signs during allogeneic human umbilical cord-derived mesenchymal stem cells infusion	24
Knee meniscus regeneration using autogenous injection of uncultured adipose tissue-derived regenerative cells	23
Systematic review: Impact of stem cells-based therapy, and platelet-rich plasma in hair loss and telogen effluvium related to COVID-19	23
Decreasing electricity costs of clean room for cell products during non-operation	22
Human growth hormone-overexpressing adipose-derived stem cells enhance fibroblast activity and accelerate burn wound healing via ERK pathway therapeutic potential of ADSCs in burn wound repair	21
DDIT4 participates in high glucose-induced fibroblast-like synoviocytes overactivation and cartilage injury by regulating glycolysis	21
Self-assembling peptide nanofibers and nanoceramics in a model of alveolar bone repair: Insights from in vivo experiments and clinical trial	20
Harvesting methods of umbilical cord-derived mesenchymal stem cells from culture modulate cell properties and functions	20
Current challenges and future directions of ATMPs in regenerative medicine	20
Human umbilical cord mesenchymal stem cells protect MC3T3-E1 osteoblasts from dexamethasone-induced apoptosis via induction of the Nrf2-ARE signaling pathway	20
Electro-spun piezoelectric PLLA smart composites as a scaffold on bone fracture: A review	20
Mechanisms of extracorporeal shock wave therapy in burn scar repair: Advances in immunoactivation-based scar remodeling research	20
Editorial Board	19
Mesenchymal stem cell for hemorrhagic stroke: A clinical review	19
Effects of fresh bone marrow mononuclear cell therapy in rat model of retinopathy of prematurity	19
Opinions on research involving human embryo models by researchers and the general public	19
Interposition grafting of collagen-gelatin sponge impregnated with basic fibroblast growth factor in primary palatoplasty	19
Corrigendum to “Advances in sciatic nerve regeneration: A review of contemporary techniques” [Regen Ther, Volume 29C, (June 2025), 563–574]	18
Development of hydroxyapatite-coated nonwovens for efficient isolation of somatic stem cells from adipose tissues	18
Neural regeneration ability of Polypyrrole-Collagen-Quercetin composite in the spinal cord injury	18
Cbx7 promotes the generation of induced pluripotent stem cells	18
Isolation of small extracellular vesicles by interacting with inorganic surface	18
Fabrication of gelatine/fucoidan nanogel-coated silver nanoparticles for the treatment of wound healing therapy and nursing care	18
Development of rematuration of canine chemically induced hepatic progenitor cells using 3D rocking culture	18
Development of a digital analysis system for a novel 3D culture-based colony formation to detect malignantly transformed cells in human cell-based therapeutic products	18
An efficient feeder-free and chemically-defined expansion strategy for highly purified natural killer cells derived from human cord blood	18
A novel cell source for therapy of knee osteoarthritis using atelocollagen microsphere-adhered adipose-derived stem cells: Impact of synovial fluid exposure on cell activity	18
Bioactive and biodegradable hydrogel based on the dermal matrix loaded with microspheres containing vascular endothelial growth factor (VEGF) and interleukin (IL)-10 accelerated the healing of diabeti	17
Effects of basic fibroblast growth factor on cartilage to bone: Time-course histological analysis of in vivo cartilage formation from polydactyly-derived chondrocytes	17
Therapeutic potential of exosomes derived from human endometrial mesenchymal stem cells for heart tissue regeneration after myocardial infarction	17
Unveiling the superior function of RADA in bone regeneration compared to KSL as two critical cores within self-assembling peptide nanofibers: Insights from in vitro and in vivo studies	17
Actin mesh in Re-epithelialization during skin regeneration in adult newt (Cynops pyrrhogaster)	17
Curcumin-based smart responsive hydrogels: A controlled release system for bone defect regeneration	17

In vitro and functional investigation reveals the curative effect of thymoquinone from black cumin-loaded chitosan nanoparticles on streptozotocin induced paediatric diabetes	17
The therapeutic potential of neuroglobin-overexpressing human neural stem cells in a photothrombosis model	16
In vitro polarized macrophages ameliorate adverse cardiac remodeling in a mouse model of transverse aortic constriction	16
Standardizing decellularization protocols for optimized uterine tissue bioengineering	16
Research of in vivo reprogramming toward clinical applications in regenerative medicine: A concise review	16
Phenotypic features of genetically modified DMD-XKOXWT pigs	16
Transplantation of chemically-induced liver progenitor cells ameliorates hepatic fibrosis in mice with diet-induced nonalcoholic steatohepatitis	16
Bibliometric analysis of hydrogels in bone regeneration: Research trends and future perspectives	16
Promotion of hMDSC differentiation by combined action of scaffold material and TGF-β superfamily growth factors	16
A new soft tissue constructed with chitosan for wound dressings-incorporating nanoparticles for medical and nursing therapeutic efficacy	15
Recommendations for the safe implementation of intravenous administration of mesenchymal stromal cells	15
NSUN2-engineered human umbilical cord mesenchymal stem cell-derived exosomes ameliorate tendon injury by promoting DNM2 expression	15
Transplantation of human umbilical cord blood mononuclear cells promotes functional endometrium reconstruction via downregulating EMT in damaged endometrium	15
miR-30a inhibits the osteogenic differentiation of the tibia-derived MSCs in congenital pseudarthrosis via targeting HOXD8	15
Technology using simulated microgravity	15
Evaluation of decellularized caprine small intestine submucosa encapsulated with nano-formulations of cerium oxide and curcumin in the management of burn wound	15
Basic Points to Consider for Cell Storage under the Act on the Safety of Regenerative Medicine in Japan	15
Human corneal organoid has a limbal function that supplies epithelium to the cornea with limbal deficiency	15
Fenugreek seed extract combined with acellular nerve allografts promotes peripheral nerve regeneration and neovascularization in sciatic nerve defects	15
Enriched human embryonic stem cells-derived CD133+, CD24+ renal progenitors engraft and restore function in a gentamicin-induced kidney injury in mice	15
Printable biomaterials for 3D brain regenerative scaffolds: An in vivo biocompatibility assessment	15
Umbilical cord mesenchymal stem cells: A novel approach to intervention of ovarian ageing	14
Exosomal U2AF2 derived from human bone marrow mesenchymal stem cells attenuates the intervertebral disc degeneration through circ_0036763/miR-583/ACAN axis	14
Engineering cardiac regeneration using stem cells: Cellular sources, differentiation signatures, targeted delivery, and functional recovery	14
MiR-590-3p affects the function of adipose-derived stem cells (ADSCs) on the survival of skin flaps by targeting VEGFA	14
Effects and the mechanism of pine pollen polysaccharides on diabetic wound healing in vitro and in vivo	14
Microbial contamination risks and clinical safety in platelet-rich plasma therapy and evaluation of rapid microbial detection methods	14
Berberine ameliorates endothelial progenitor cell function and wound healing in vitro and in vivo via the miR-21-3p/RRAGB axis for venous leg ulcers	14
Subcutaneous implantation of tooth germ stem cells over the masseter muscle in mice: An in vivo pilot study	14
Human placental extract improves liver cirrhosis in mice with regulation of macrophages and senescent cells	14
Harnessing Platelet-derived factors to reactivate Nucleus Pulposus cells in Intervertebral Disc Regeneration	14
Comparisons of the effects of silk elastin and collagen sponges on wound healing in murine models	14
Pluripotent stem cell-derived retinal organoid/cells for retinal regeneration therapies: A review	13
Editorial Board	13
Stable preparation of in vivo transplantable periodontal ligament-derived mesenchymal stem cell sheets in thermoresponsive culture dishes with tunable cell detachability	13
Exosomes derived stem cells as a modern therapeutic approach for skin rejuvenation and hair regrowth	13
Viral-based gene therapy clinical trials for immune deficiencies and blood disorders from 2013 until 2023 - an overview	13
Modified human skin cell isolation protocol and its influence on keratinocyte and melanocyte culture	13
A novel role of CD73-IFNγ signalling axis in human mesenchymal stromal cell mediated inflammatory macrophage suppression	13
Modeling of intramembranous ossification using human pluripotent stem cell-derived paraxial mesoderm derivatives	13
The phenotypic characterization of mouse floxed Fam20b chondrocytes, a novel articular cartilage-derived cell line with differentiation potential	13
Investigating the effect of mesenchymal stem cells on the rate of clinical and pathological improvement of asthmatic lung in mouse model	12
Butyrate-preconditioned human adipose-derived stem cell-conditioned medium enhances myocardial perfusion after infarction	12
Relationship between oxygen partial pressure and inhibition of cell aggregation of human adipose tissue-derived mesenchymal stem cells stored in cell preservation solutions	12
Bulk RNA sequencing reveals the comprehensive genetic characteristics of human cord blood-derived natural killer cells	12
Hypoxia-preconditioned bone marrow mesenchymal stem cell-derived exosomes ameliorate knee osteoarthritis by promoting cartilage regeneration and alleviating pain in rats	12
Method standardization of secretome production, collection, and characterization: New insights and challenges	12
Personalized tissue-engineered arteries as vascular graft transplants: A safety study in sheep	12
Preface to the special issue of “Regenerative therapy”: “Future of regenerative medicine viewed by young scientists”	12
Optimal frequency of platelet-rich plasma injections for managing osteoarthritis: A longitudinal study	12
Transplantation of chemically induced liver progenitors in Nagase analbuminemic rats under liver regenerative stimulus	12
Wharton's jelly mesenchymal stem cell-secretome enhances skin rejuvenation via ApoA4 and SERPINH1	12
Dynamic tracking of human umbilical cord mesenchymal stem cells (hUC-MSCs) following intravenous administration in mice model	12
Clinical efficacy of invimestrocel for acute respiratory distress syndrome caused by pneumonia: Comparison with historical data using propensity score analysis	12
Efficacy of mesenchymal stem cells and platelet-rich plasma therapies on wound healing: A Systematic Review and meta-analysis	12
Nanosecond pulsed electric field applications rejuvenate aging endothelial cells by rescuing mitochondrial-to-nuclear retrograde communication	12
Exosome-based approaches in cancer along with unlocking new insights into regeneration of cancer-prone tissues	12
Global research dynamics in the induced pluripotent stem cell and diabetes: A bibliometric analysis of the past twenty years	12
Canine adipose-derived mesenchymal stromal cells inhibit the growth of canine hematologic malignancy cell lines	12
Tracking adipose-derived mesenchymal stromal cells in the eye: Integrating IVIS imaging and Alu PCR for enhanced detection of human cells	11
Long term observation of de novo adipogenesis using novel bioabsorbable implants with larger size in a porcine model	11
Single-cell RNA sequencing unravels heterogeneity of skeletal progenitors and cell–cell interactions underlying the bone repair process	11
Simultaneous binding of bFGF to both FGFR and integrin maintains properties of primed human induced pluripotent stem cells	11
Fabrication of Biologically Inspired Electrospun Collagen/Silk fibroin/bioactive glass composited nanofibrous scaffold to accelerate the treatment efficiency of bone repair	11
Transplantation of adipose-derived stem cell aggregates via hydrogel microspheres that incorporate growth factors increases muscle strength	11
Hydrogel in musculoskeletal diseases: Unraveling trends, research foci, and future trajectories via bibliometric insights (from 2000 to 2025)	11
Non-apoptotic regulated cell death in Fuchs endothelial corneal dystrophy	11
Scanning electron microscopy analysis of synovial and adipose mesenchymal stem cells adhering to cartilage	11
Microbiome-derived bile acids as endogenous regenerative mediators in liver repair	11
Editorial Board	11
Cholangiocyte-derived exosomal miR-381-3p promotes hepatic stellate cell activation and cholestatic liver fibrosis via targeting Klf6	11
Which trajectory should we choose? — Defining safe entry–target pathways and underlying femoral morphology for bone marrow injection in osteonecrosis of the femoral head	11
Airway basal stem cell derived extracellular vesicles promote lung repair in chronic obstructive pulmonary disease	11
Platelet-rich plasma therapy for knee osteoarthritis: Insights from real-world clinical data in Japan	11
Scalable production process development for NK cells targeting large-scale expansion	10
Design and development of pH-responsive levofloxacin-loaded metal-organic framework for the promising treatment of pediatric abdominal wound repair	10
Spatial heterogeneity analysis of seeding of human induced pluripotent stem cells for neuroectodermal differentiation	10
Reconstitution and post-thaw storage of cryopreserved human mesenchymal stromal cells: Pitfalls and optimizations for clinically compatible formulants	10
Tangeretin suppresses RANKL-induced osteoclastogenesis and alleviates postmenopausal osteoporosis by inhibiting Notch signaling	10
Role of cell-based therapies in digestive disorders: Obstacles and opportunities	10

Abnormal circ-CDK8 expression affects periodontitis development by regulating let-7b-5p/MAP4K3 signaling	10
Autologous concentrated growth factor mediated accelerated bone healing in root-end microsurgery: A multicenter randomized clinical trial	10
Mesenchymal stem cell-derived extracellular vesicles/exosome: A promising therapeutic strategy for intracerebral hemorrhage	10
The superficial branch of the radial nerve and sensory disturbance in the radial forearm flap donor-site	10
Corrigendum to “Salvianolic acid A facilitates cartilage repair in knee osteoarthritis model rats by promoting WDR5 expression” [Regen Therapy 29C (2025) 77–90/880]	10
Association with cationized gelatin nanospheres enhances cell internalization of mitochondria efficiency	10
Research trends on platelet-rich plasma in improving ovarian dysfunction: A bibliometric and visualization analysis	10
Mesenchymal stem cells: Guardians of women's health	9
Assessment of permeability in deep tissue capillaries using a new method reflects the nutrient supply status in a healthy heart	9
Dendrobium officinale polysaccharide promotes angiogenesis as well as follicle regeneration and hair growth through activation of the WNT signaling pathway	9
Investigating the attenuating effects of metformin-loaded selenium nanoparticles coupled with Myrtus communis L. flower extract on CaOx deposition in male Sprague Dawley rat kidneys via regulating MAP	9
Nisin-preconditioned mesenchymal stem cells combatting nosocomial Pseudomonas infections	9
Iron-Quercetin complex enhances mesenchymal stem cell-mediated HGF secretion and c-Met activation to ameliorate acute kidney injury through the prevention of tubular cell apoptosis	9
Preventing MSC aging and enhancing immunomodulation: Novel strategies for cell-based therapies	9
Lpar3-mediated macrophage polarization promotes inflammatory tooth extraction socket healing and alveolar bone regeneration	9
Prognostic factors affecting periodontal regenerative therapy using recombinant human fibroblast growth factor-2: A 3-year cohort study	9
The NFATC2/Nrf2 cascade regulates spinal cord ischemia-reperfusion injury by controlling inflammation, apoptosis and oxidative stress	9
Establishment of reproducible method for production of cultured epidermal sheets with controlled melanocyte density	9
Generation of functional liver sinusoidal endothelial-like cells from human bone marrow-derived mesenchymal stem cells	9
Mesenchymal stem cell therapy in ischemic stroke trials. A systematic review	9
Effect of a FOXO1 inhibitor on trophoblast differentiation from human pluripotent stem cells and ERV-associated gene expression	9
Inhibition of the TLR4/RAGE pathway by clearance of extracellular HMGB1 is a potential therapeutic target for radiation-damaged salivary glands	9
Evaluating the quality of studies reporting on clinical applications of stromal vascular fraction: A systematic review and proposed reporting guidelines (CLINIC-STRA-SVF)	9
Current regenerative medicine-based approaches for skin regeneration: A review of literature and a report on clinical applications in Japan	9
Potential therapeutic effects and nano-based delivery systems of mesenchymal stem cells and their isolated exosomes to alleviate acute respiratory distress syndrome caused by COVID-19	9