OOIR: Observatory of International Research

Papers

(The TQCC of Regenerative Therapy is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Applications of 3D printed bone tissue engineering scaffolds in the stem cell field	113
Research progress in decellularized extracellular matrix-derived hydrogels	94
First-in-human clinical trial of transplantation of iPSC-derived NS/PCs in subacute complete spinal cord injury: Study protocol	84
Immune evasion by cancer stem cells	71
Degenerative osteoarthritis a reversible chronic disease	54
Three dimensional printed nanostructure biomaterials for bone tissue engineering	53
Stem cell therapy for osteonecrosis of femoral head: Opportunities and challenges	45
Regenerative medicine strategies for hair growth and regeneration: A narrative review of literature	37
Comparison of therapeutic effects of encapsulated Mesenchymal stem cells in Aloe vera gel and Chitosan-based gel in healing of grade-II burn injuries	34
Biologically modified implantation as therapeutic bioabsorbable materials for bone defect repair	30
The application of bone marrow mesenchymal stem cells and biomaterials in skeletal muscle regeneration	30
Conflicting metabolic alterations in cancer stem cells and regulation by the stromal niche	29
TGF-β1-containing exosomes derived from bone marrow mesenchymal stem cells promote proliferation, migration and fibrotic activity in rotator cuff tenocytes	27
Molecular pathology underlying the robustness of cancer stem cells	25
Role of platelet rich plasma mediated repair and regeneration of cell in early stage of cardiac injury	24
iPSC for modeling neurodegenerative disorders	23
miRNA signaling networks in cancer stem cells	23
Proteomic analysis of platelet-rich and platelet-poor plasma	22
Current status of ischemic stroke treatment: From thrombolysis to potential regenerative medicine	21
LncRNA MALAT1 promotes wound healing via regulating miR-141-3p/ZNF217 axis	21
Current regenerative medicine-based approaches for skin regeneration: A review of literature and a report on clinical applications in Japan	21
A silk fibroin/chitosan/nanohydroxyapatite biomimetic bone scaffold combined with autologous concentrated growth factor promotes the proliferation and osteogenic differentiation of BMSCs and repair of	20
Osteochondral regeneration using scaffold-free constructs of adipose tissue-derived mesenchymal stem cells made by a bio three-dimensional printer with a needle-array in rabbits	20
The promising rise of bioprinting in revolutionalizing medical science: Advances and possibilities	20
Fabrication of Biologically Inspired Electrospun Collagen/Silk fibroin/bioactive glass composited nanofibrous scaffold to accelerate the treatment efficiency of bone repair	18

Human umbilical cord mesenchymal stem cell-derived exosomes promote neurological function recovery in rat after traumatic brain injury by inhibiting the activation of microglia and astrocyte	18
New insight of immuno-engineering in osteoimmunomodulation for bone regeneration	18
Dental pulp-derived stem cell-conditioned media attenuates secondary Sjögren's syndrome via suppression of inflammatory cytokines in the submandibular glands	18
Mesenchymal stem cell therapy: A review of clinical trials for multiple sclerosis	17
Dental pulp stem cells response on the nanotopography of scaffold to regenerate dentin-pulp complex tissue	17
Pluripotent stem cell-derived retinal organoid/cells for retinal regeneration therapies: A review	16
Basic fibroblast growth factor enhances proliferation and hepatocyte growth factor expression of feline mesenchymal stem cells	16
Mesenchymal stem cell extracellular vesicles-derived microRNA-194-5p delays the development of intervertebral disc degeneration by targeting TRAF6	16
Regenerative potential of pluripotent nontumorgenetic stem cells: Multilineage differentiating stress enduring cells (Muse cells)	16
Repair of spinal cord injury in rats via exosomes from bone mesenchymal stem cells requires sonic hedgehog	16
Liver cancer stem cells: Recent progress in basic and clinical research	15
Human bone marrow mesenchymal stem cell-derived exosomes containing microRNA-425 promote migration, invasion and lung metastasis by down-regulating CPEB1	15
An exploratory clinical trial to evaluate the safety and efficacy of combination therapy of REGROTH® and Cytrans® granules for severe periodontitis with intrabony defects	15
Establishment of an efficient ex vivo expansion strategy for human natural killer cells stimulated by defined cytokine cocktail and antibodies against natural killer cell activating receptors	15
Fibronectin-coating enhances attachment and proliferation of mesenchymal stem cells on a polyurethane meniscal scaffold	15
Extracellular microvesicles that originated adipose tissue derived mesenchymal stem cells have the potential ability to improve rheumatoid arthritis on mice	14
Mesenchymal stem cell-derived extracellular vesicles/exosome: A promising therapeutic strategy for intracerebral hemorrhage	14
Biodistribution studies for cell therapy products: Current status and issues	14
Investigating the Impact of Collagen-Chitosan Derived from Scomberomorus Guttatus and Shrimp Skin on Second-Degree Burn in Rats Model	14
The protective mechanism of Klotho gene-modified bone marrow mesenchymal stem cells on acute kidney injury induced by rhabdomyolysis	13
Safety and efficacy of bone marrow derived-mesenchymal stem cells transplantation in patients with amyotrophic lateral sclerosis	13
Role of quercetin and rutin in enhancing the therapeutic potential of mesenchymal stem cells for cold induced burn wound	13
Heparin-conjugated collagen as a potent growth factor-localizing and stabilizing scaffold for regenerative medicine	13
In vitro effects of conditioned medium from bioreactor cultured human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) on skin-derived cell lines	13
Three-dimensional spheroids of dedifferentiated fat cells enhance bone regeneration	13
Clinical trial of autologous adipose tissue-derived regenerative (stem) cells therapy for exploration of its safety and efficacy	13
Assessment of human bioengineered cardiac tissue function in hypoxic and re-oxygenized environments to understand functional recovery in heart failure	13
Hyaluronic acid hydrogels crosslinked via blue light-induced thiol-ene reaction for the treatment of rat corneal alkali burn	12
Polydopamine-coated biomimetic bone scaffolds loaded with exosomes promote osteogenic differentiation of BMSC and bone regeneration	12
Are mesenchymal stem cells able to manage cytokine storm in COVID-19 patients? A review of recent studies	12
Mesenchymal stem cells pretreated with proinflammatory cytokines accelerate skin wound healing by promoting macrophages migration and M2 polarization	12
Cancer stem cell-like cells-derived exosomal lncRNA CDKN2B-AS1 promotes biological characteristics in thyroid cancer via miR-122-5p/P4HA1 axis	11
CircRNA_25487 inhibits bone repair in trauma-induced osteonecrosis of femoral head by sponging miR-134-3p through p21	11
Gelatin hydrogel nonwoven fabrics of a cell culture scaffold to formulate 3-dimensional cell constructs	11
A case series of platelet rich plasma in chronic venous ulcers	11
Immunosuppressive mesenchymal stem cells aggregates incorporating hydrogel microspheres promote an in vitro invasion of cancer cells	11
Cryoprotective enhancing effect of very low concentration of trehalose on the functions of primary rat hepatocytes	11
Advanced Therapy medicinal products for autologous chondrocytes and comparison of regulatory systems in target countries	11
Low-temperature extrusion-based 3D printing of icariin-laden scaffolds for osteogenesis enrichment	10
Facial nerve regeneration with bioabsorbable collagen conduits filled with collagen filaments: An experimental study	10
Inorganic polyphosphate in platelet rich plasma accelerates re-epithelialization in vitro and in vivo	10
Novel device prototyping for endoscopic cell sheet transplantation using a three-dimensional printed simulator	10
Granulocyte differentiation of rat bone marrow resident C-kit+ hematopoietic stem cells induced by mesenchymal stem cells could be considered as new option in cell-based therapy	10
Adipose stem cells in tissue regeneration and repair: From bench to bedside	10
Targeting cancer stem cells in refractory cancer	10
A review and update for registered clinical studies of stem cells for non-tumorous and non-hematological diseases	10
Urinary bladder reconstruction using autologous collagenous connective tissue membrane “Biosheet®” induced by in-body tissue architecture: A pilot study	10
Transplantation of a human induced pluripotent stem cell-derived airway epithelial cell sheet into the middle ear of rats	10
The hsa-miR-302 cluster controls ectodermal differentiation of human pluripotent stem cell via repression of DAZAP2	10
Surface modulation of extracellular vesicles with cell-penetrating peptide-conjugated lipids for improvement of intracellular delivery to endothelial cells	10

CircRNA PVT1 modulated cell migration and invasion through Epithelial-Mesenchymal Transition (EMT) mediation in gastric cancer through miR-423-5p/Smad3 pathway	10
3D printed drug loaded nanomaterials for wound healing applications	9
Application of mesenchymal stem cells combined with nano-polypeptide hydrogel in tissue engineering blood vessel	9
Prognostic factors affecting periodontal regenerative therapy using recombinant human fibroblast growth factor-2: A 3-year cohort study	9
External administration of moon jellyfish collagen solution accelerates physiological wound healing and improves delayed wound closure in diabetic model mice	9
Carbachol, along with calcium, indicates new strategy in neural differentiation of human adipose tissue-derived mesenchymal stem cells in vitro	9
S100A8 accelerates wound healing by promoting adipose stem cell proliferation and suppressing inflammation	9
Single-cell RNA sequencing unravels heterogeneity of skeletal progenitors and cell–cell interactions underlying the bone repair process	9
Efficient cell transplantation combining injectable hydrogels with control release of growth factors	9
Phenotypic and functional properties of dedifferentiated fat cells derived from infrapatellar fat pad	9
Combination therapy of Juzentaihoto and mesenchymal stem cells attenuates liver damage and regresses fibrosis in mice	9
Characterization of autologous platelet rich plasma (PRP) and its biological effects in patients with Behçet's Disease	9
Personalized tissue-engineered arteries as vascular graft transplants: A safety study in sheep	9
Addition of Chk1 inhibitor and BMP4 cooperatively promotes retinal tissue formation in self-organizing human pluripotent stem cell differentiation culture	8
Basic points to consider regarding the preparation of extracellular vesicles and their clinical applications in Japan	8
Regenerative medicine for the upper gastrointestinal tract	8
In vitro and in vivo evaluation of electrospun poly (ε-caprolactone)/collagen scaffolds and Wharton's jelly mesenchymal stromal cells (hWJ-MSCs) constructs as potential alternative for skin tissue eng	8
Laminin-511-derived recombinant fragment and Rho kinase inhibitor Y-27632 facilitate serial cultivation of keratinocytes differentiated from human embryonic stem cells	8
Progress of esophageal stricture prevention after endoscopic submucosal dissection by regenerative medicine and tissue engineering	8
Effects of conditioned medium obtained from human adipose-derived stem cells on skin inflammation	8
A comparative analysis of attitudes toward stem cell research and regenerative medicine between six countries – A pilot study	8
Circ_0087960 stabilizes KDM5B by reducing SKP2 mediated ubiquitination degradation and promotes osteogenic differentiation in periodontal ligament stem cells	8
Exosomes derived from human placental mesenchymal stem cells in combination with hyperbaric oxygen synergically alleviates spinal cord ischemia-reperfusion injury	8
Cryopreservation of undifferentiated and differentiated human neuronal cells	8
Safety study of allogeneic mesenchymal stem cell therapy in animal model	8
Development of appropriate fatty acid formulations to raise the contractility of constructed myocardial tissues	7
Osteogenic differentiation of pre-conditioned bone marrow mesenchymal stem cells with Nisin on modified poly-L-lactic-acid nanofibers	7
Cells, growth factors and biomaterials used in tissue engineering for hair follicles regeneration	7
A novel cardiac differentiation method of a large number and uniformly-sized spheroids using microfabricated culture vessels	7
Enhancing chondrogenic potential via mesenchymal stem cell sheet multilayering	7
Effects of combined application of fibroblast growth factor (FGF)-2 and carbonate apatite for tissue regeneration in a beagle dog model of one-wall periodontal defect	7
Comparison of the 2021 International Society for Stem Cell Research (ISSCR) guidelines for “laboratory-based human stem cell research, embryo research, and related research activities” and the corresp	7
RUNX3 derived hsa_circ_0005752 accelerates the osteogenic differentiation of adipose-derived stem cells via the miR-496/MDM2-p53 pathway	7
YY1-induced lncRNA XIST inhibits cartilage differentiation of BMSCs by binding with TAF15 to stabilizing FUT1 expression	7
Study protocol for periodontal tissue regeneration with a mixture of autologous adipose-derived stem cells and platelet rich plasma: A multicenter, randomized, open-label clinical trial	7
Role of osteopontin in the process of pulpal healing following tooth replantation in mice	7
Tissue engineering and stem cell-based therapeutic strategies for premature ovarian insufficiency	7
Laser emission at 675 nm: In vitro study evidence of a promising role in skin rejuvenation	7
Exosomes derived from odontogenic stem cells: Its role in the dentin-pulp complex	7
Bone formation potential of collagen type I-based recombinant peptide particles in rat calvaria defects	7
Successful engraftment of epithelial cells derived from autologous rabbit buccal mucosal tissue, encapsulated in a polymer scaffold in a rabbit model of a urethral stricture, transplanted using the tr	7
PPAR-δ agonist affects adipo-chondrogenic differentiation of human mesenchymal stem cells through the expression of PPAR-γ	7
Development of gelatin hydrogel nonwoven fabrics (Genocel®) as a novel skin substitute in murine skin defects	6
Exosomes derived from human umbilical cord mesenchymal stem cells protect against papain-induced emphysema by preventing apoptosis through activating VEGF-VEGFR2-mediated AKT and MEK/ERK pathways in r	6
The immature platelet fraction affects the efficacy of platelet rich plasma therapy for knee osteoarthritis	6
A study on the clinical application of greater omental pedicle flap transplantation to correct anterior resection syndrome in patients with low rectal cancer	6
Recombinant canine basic fibroblast growth factor-induced differentiation of canine bone marrow mesenchymal stem cells into voltage- and glutamate-responsive neuron-like cells	6
CRISPR/Cas9 and AAV mediated insertion of β2 microglobulin-HLA-G fusion gene protects mesenchymal stromal cells from allogeneic rejection and potentiates the use for off-the-shelf cell therapy	6
Clinical use of autologous adipose-derived stromal vascular fraction cell injections for hip osteoarthritis	6
Advancements in drug-loaded hydrogel systems for bone defect repair	6
Cultured epithelial autografts for the treatment of large-to-giant congenital melanocytic nevus in 31 patients	6
Long term improvement of knee osteoarthritis after injection of single high/very high volume of very pure PRP: A retrospective analysis of patients optimally managed in dedicated centers	6
MiRNA-320a-5p contributes to the homeostasis of osteogenesis and adipogenesis in bone marrow mesenchymal stem cell	6
Modeling human congenital disorders with neural crest developmental defects using patient-derived induced pluripotent stem cells	6
Long-term observation of airway reconstruction using decellularized tracheal allografts in micro-miniature pigs at growing stage	6
Return to the original sport at only 3 months after an Achilles tendon rupture by a combination of intra-tissue injection of freeze-dried platelet-derived factor concentrate and excessively early reha	6
Allogeneic transplantation of epidermal cell sheets followed by endoscopic submucosal dissection to prevent severe esophageal stricture in a porcine model	6
Gaps between Asian regulations for eligibility of human mesenchymal stromal cells as starting materials of cell therapy products and comparability of mesenchymal stromal cell-based products subject to	6
Repair of ovine peripheral nerve injuries with xenogeneic human acellular sciatic nerves prerecellularized with allogeneic Schwann-like cells—an innovative and promising approach	6
Subcutaneous transplantation of engineered islet/adipose-derived mesenchymal stem cell sheets in diabetic pigs with total pancreatectomy	6
Xenogeneic mesenchymal stem cell biocurative improves skin wounds healing in diabetic mice by increasing mast cells and the regenerative profile	6
Functional changes of cocultured hepatocyte sheets subjected to continuous liver regeneration stimulation in cDNA-uPA/SCID mouse: Differences in transplantation sites	6
MiRNA-218 inhibits cell proliferation, migration and invasion by targeting Runt-related transcription factor 2 (Runx2) in human osteosarcoma cells	6
Regenerative therapy by using mesenchymal stem cells-derived exosomes in COVID-19 treatment. The potential role and underlying mechanisms	6
METTL3 promotes SMSCs chondrogenic differentiation by targeting the MMP3, MMP13, and GATA3	6