Regenerative Therapy

Article	Citations
The generation of islet-like insulin-producing cells from Wharton's jelly-derived mesenchymal stem cells on the PES/fish gelatin scaffold	134
Xenotransplantation of cryopreserved human clumps of mesenchymal stem cells/extracellular matrix complexes pretreated with IFN-γ induces rat calvarial bone regeneration	125
Effect of silk fibroin scaffold loaded with 17-β estradiol on the proliferation and differentiation of BMSCs	88
Positive effect of Periostin on repair of Isopreternol induced ischemic damaged cardiomyocyte: an in vitro model	70
Effects of plasma rich in growth factors on wound healing in patients with venous ulcers	56
Study on promoting the regeneration of grafted fat by cell-assisted lipotransfer	46
Chronic prosthesis-related residual limb ulcer treated with autologous micro-fragmented adipose tissue	45
Bridging potential of Taurine-loading PCL conduits transplanted with hEnSCs on resected sciatic nerves	45
CD73-positive pediatric urethral mesenchymal stem-like cell-derived small extracellular vesicles stimulate angiogenesis	42
Estradiol enhanced neuronal plasticity and ameliorated astrogliosis in human iPSC-derived neural models	41
Diverting the food-freezing technology improves the cryopreservation efficiency of induced pluripotent stem cells and derived neurospheres	38
Selective effects of collagen-derived peptides Pro-Hyp and Hyp-Gly on the proliferation and differentiation of SSEA3-positive human dental pulp stem cells	35
Baseline magnetic resonance imaging findings associated with short-term clinical outcomes after intraarticular administration of autologous adipose-derived stem cells for knee osteoarthritis	35
The potential of Spirulina maxima extract-treated conditioned medium from adipose-derived mesenchymal stem cells for hair growth promoting effect on human dermal papilla cells	34
CircRNA PVT1 modulated cell migration and invasion through Epithelial-Mesenchymal Transition (EMT) mediation in gastric cancer through miR-423-5p/Smad3 pathway	33
Comparative gastrointestinal organoid models across species: A Zoobiquity approach for precision medicine	32
Circ_ROBO2/miR-186-5p/TRIM14 axis regulates oxidized low-density lipoprotein-induced cardiac microvascular endothelial cell injury	32
Research status of facial nerve repair	32
Human iPSC-derived cerebral organoids reveal oxytocin-mediated protection against amyloid-β pathology	31
Return to the original sport at only 3 months after an Achilles tendon rupture by a combination of intra-tissue injection of freeze-dried platelet-derived factor concentrate and excessively early reha	31
The role of telomeres in leukemic stem cells function	31
Efficient cell transplantation combining injectable hydrogels with control release of growth factors	30
Adipogenesis of bioabsorbable implants under irradiation in a rodent model	29
Stress and motivation of cell processing operators: A pilot study of an online questionnaire survey	29
A new clinical classification and reconstructive strategy for post-sternotomy surgical site infection	28

In vitro effects of conditioned medium from bioreactor cultured human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) on skin-derived cell lines	28
Prospects and challenges in NMDAR signaling in spinal cord injury recovery and neural circuit remodeling	27
Optimal dose of bone marrow mesenchymal stem cell transplantation for experimental ulcerative colitis	26
Intrauterine injection of bioengineered hydrogel loaded exosomes derived from HUCM stem cells and spermidine prominently augments the pregnancy rate in thin endometrium rats	26
Xenogeneic mesenchymal stem cell biocurative improves skin wounds healing in diabetic mice by increasing mast cells and the regenerative profile	25
Bone morphogenetic protein-2-derived osteogenic peptide promotes bone regeneration via osteoblastogenesis	24
Modeling human congenital disorders with neural crest developmental defects using patient-derived induced pluripotent stem cells	24
BNIP3 induced by hypoxia supports the survival of mesenchymal stromal cells (MSCs) after intravenous cell transplantation	24
Clinical challenges of short bowel syndrome and the path forward for organoid-based regenerative medicine	24
Development of pyrogen-free utensils for cell culture by combining ozone/hydrogen peroxide mixed gas sterilization with steam-washing technology	23
The research landscape and trends of dental pulp stem cell studies (2010–2025): A bibliometric analysis	23
Downregulation of hsa_circ_0000885 suppressed osteosarcoma metastasis and progression via regulating E2F3 expression and sponging miR-16-5p	22
Alkali-extracted proteins from the tooth dentin matrix as a mixture of bioactive molecules for cartilage repair and regeneration	22
Phenytoin regulates osteogenic differentiation of human bone marrow stem cells by PI3K/Akt pathway	22
Regenerative medicine strategies for hair growth and regeneration: A narrative review of literature	22
Tanshinone IIA protects motor neuron-like NSC-34 cells against lipopolysaccharide-induced cell injury by the regulation of the lncRNA TCTN2/miR-125a-5p/DUSP1 axis	21
Human umbilical cord mesenchymal stem cells protect MC3T3-E1 osteoblasts from dexamethasone-induced apoptosis via induction of the Nrf2-ARE signaling pathway	21
Systematic review: Impact of stem cells-based therapy, and platelet-rich plasma in hair loss and telogen effluvium related to COVID-19	21
Knee meniscus regeneration using autogenous injection of uncultured adipose tissue-derived regenerative cells	21
Characterization of dynamical changes in vital signs during allogeneic human umbilical cord-derived mesenchymal stem cells infusion	21
Intra-articular administration of autologous adipose-derived stem cells in hip osteoarthritis: Longitudinal treatment trajectories and prognostic factors	20
DDIT4 participates in high glucose-induced fibroblast-like synoviocytes overactivation and cartilage injury by regulating glycolysis	20
Self-assembling peptide nanofibers and nanoceramics in a model of alveolar bone repair: Insights from in vivo experiments and clinical trial	20
Harvesting methods of umbilical cord-derived mesenchymal stem cells from culture modulate cell properties and functions	19
Electro-spun piezoelectric PLLA smart composites as a scaffold on bone fracture: A review	19
Efficacy of chitinase-3-like protein 1 as an in vivo bone formation predictable marker of maxillary/mandibular bone marrow stromal cells	19
Current challenges and future directions of ATMPs in regenerative medicine	18
Human growth hormone-overexpressing adipose-derived stem cells enhance fibroblast activity and accelerate burn wound healing via ERK pathway therapeutic potential of ADSCs in burn wound repair	18
Polydactyly bone marrow-derived mesenchymal stem cell-conditioned medium can prevent cartilage degeneration and alleviate knee pain in a rat model of osteoarthritis	18
Decreasing electricity costs of clean room for cell products during non-operation	18
Mechanisms of extracorporeal shock wave therapy in burn scar repair: Advances in immunoactivation-based scar remodeling research	18
Conditioned plasma promotes full-thickness skin defect healing in a rat model	18
Clinical trial of autologous adipose tissue-derived regenerative (stem) cells therapy for exploration of its safety and efficacy	17
Interposition grafting of collagen-gelatin sponge impregnated with basic fibroblast growth factor in primary palatoplasty	17
Cbx7 promotes the generation of induced pluripotent stem cells	17
An efficient feeder-free and chemically-defined expansion strategy for highly purified natural killer cells derived from human cord blood	17
Therapeutic potential of exosomes derived from human endometrial mesenchymal stem cells for heart tissue regeneration after myocardial infarction	17
Neural regeneration ability of Polypyrrole-Collagen-Quercetin composite in the spinal cord injury	16
Editorial Board	16
A case series of platelet rich plasma in chronic venous ulcers	16
Effects of fresh bone marrow mononuclear cell therapy in rat model of retinopathy of prematurity	16
A novel cell source for therapy of knee osteoarthritis using atelocollagen microsphere-adhered adipose-derived stem cells: Impact of synovial fluid exposure on cell activity	15
Unveiling the superior function of RADA in bone regeneration compared to KSL as two critical cores within self-assembling peptide nanofibers: Insights from in vitro and in vivo studies	15
Development of hydroxyapatite-coated nonwovens for efficient isolation of somatic stem cells from adipose tissues	15
Opinions on research involving human embryo models by researchers and the general public	14
Evaluation of decellularized caprine small intestine submucosa encapsulated with nano-formulations of cerium oxide and curcumin in the management of burn wound	14
Bioactive and biodegradable hydrogel based on the dermal matrix loaded with microspheres containing vascular endothelial growth factor (VEGF) and interleukin (IL)-10 accelerated the healing of diabeti	14
Mesenchymal stem cell for hemorrhagic stroke: A clinical review	14
Development of rematuration of canine chemically induced hepatic progenitor cells using 3D rocking culture	14
Fabrication of gelatine/fucoidan nanogel-coated silver nanoparticles for the treatment of wound healing therapy and nursing care	14

Corrigendum to “Advances in sciatic nerve regeneration: A review of contemporary techniques” [Regen Ther, Volume 29C, (June 2025), 563–574]	14
Actin mesh in Re-epithelialization during skin regeneration in adult newt (Cynops pyrrhogaster)	13
Standardizing decellularization protocols for optimized uterine tissue bioengineering	13
Adipose-derived mesenchymal stem cells preserve cardiac function via ANT-1 in dilated cardiomyopathy hamster model	13
Bibliometric analysis of hydrogels in bone regeneration: Research trends and future perspectives	13
Promotion of hMDSC differentiation by combined action of scaffold material and TGF-β superfamily growth factors	13
A new soft tissue constructed with chitosan for wound dressings-incorporating nanoparticles for medical and nursing therapeutic efficacy	13
Human corneal organoid has a limbal function that supplies epithelium to the cornea with limbal deficiency	13
Editorial Board	13
In vitro and functional investigation reveals the curative effect of thymoquinone from black cumin-loaded chitosan nanoparticles on streptozotocin induced paediatric diabetes	13
Enriched human embryonic stem cells-derived CD133+, CD24+ renal progenitors engraft and restore function in a gentamicin-induced kidney injury in mice	13
Recommendations for the safe implementation of intravenous administration of mesenchymal stromal cells	13
Transplantation of human umbilical cord blood mononuclear cells promotes functional endometrium reconstruction via downregulating EMT in damaged endometrium	13
Reawakening GDNF's regenerative past in mice and humans	13
Phenotypic features of genetically modified DMD-XKOXWT pigs	13
Effects of basic fibroblast growth factor on cartilage to bone: Time-course histological analysis of in vivo cartilage formation from polydactyly-derived chondrocytes	13
Research of in vivo reprogramming toward clinical applications in regenerative medicine: A concise review	12
The therapeutic potential of neuroglobin-overexpressing human neural stem cells in a photothrombosis model	12
Transplantation of chemically-induced liver progenitor cells ameliorates hepatic fibrosis in mice with diet-induced nonalcoholic steatohepatitis	12
Human placental extract improves liver cirrhosis in mice with regulation of macrophages and senescent cells	12
Technology using simulated microgravity	12
Basic Points to Consider for Cell Storage under the Act on the Safety of Regenerative Medicine in Japan	12
Comparisons of the effects of silk elastin and collagen sponges on wound healing in murine models	12
Fenugreek seed extract combined with acellular nerve allografts promotes peripheral nerve regeneration and neovascularization in sciatic nerve defects	12
Printable biomaterials for 3D brain regenerative scaffolds: An in vivo biocompatibility assessment	12
Subcutaneous implantation of tooth germ stem cells over the masseter muscle in mice: An in vivo pilot study	12
Umbilical cord mesenchymal stem cells: A novel approach to intervention of ovarian ageing	12
Viral-based gene therapy clinical trials for immune deficiencies and blood disorders from 2013 until 2023 - an overview	12
Pluripotent stem cell-derived retinal organoid/cells for retinal regeneration therapies: A review	11
Stable preparation of in vivo transplantable periodontal ligament-derived mesenchymal stem cell sheets in thermoresponsive culture dishes with tunable cell detachability	11
Human bone marrow mesenchymal stem cell-derived exosomes containing microRNA-425 promote migration, invasion and lung metastasis by down-regulating CPEB1	11
miR-30a inhibits the osteogenic differentiation of the tibia-derived MSCs in congenital pseudarthrosis via targeting HOXD8	11
MiR-590-3p affects the function of adipose-derived stem cells (ADSCs) on the survival of skin flaps by targeting VEGFA	11
Superior stemness of a rapidly growing subgroup of isolated human auricular chondrocytes and the potential for use in cartilage regenerative therapy	11
Editorial Board	11
A novel role of CD73-IFNγ signalling axis in human mesenchymal stromal cell mediated inflammatory macrophage suppression	11
Berberine ameliorates endothelial progenitor cell function and wound healing in vitro and in vivo via the miR-21-3p/RRAGB axis for venous leg ulcers	11
Exosomal U2AF2 derived from human bone marrow mesenchymal stem cells attenuates the intervertebral disc degeneration through circ_0036763/miR-583/ACAN axis	11
Effects and the mechanism of pine pollen polysaccharides on diabetic wound healing in vitro and in vivo	11
Current status of ischemic stroke treatment: From thrombolysis to potential regenerative medicine	11
Modeling of intramembranous ossification using human pluripotent stem cell-derived paraxial mesoderm derivatives	11
Exosomes derived stem cells as a modern therapeutic approach for skin rejuvenation and hair regrowth	11
Transplantation of acellularized dermis matrix (ADM) plus fully covered metal stent to prevent stricture after circumferential endoscopic submucosal dissection of early esophageal cancer (with video)	10
Relationship between oxygen partial pressure and inhibition of cell aggregation of human adipose tissue-derived mesenchymal stem cells stored in cell preservation solutions	10
Method standardization of secretome production, collection, and characterization: New insights and challenges	10
Bulk RNA sequencing reveals the comprehensive genetic characteristics of human cord blood-derived natural killer cells	10
Non-apoptotic regulated cell death in Fuchs endothelial corneal dystrophy	10
Scanning electron microscopy analysis of synovial and adipose mesenchymal stem cells adhering to cartilage	10
Efficacy of mesenchymal stem cells and platelet-rich plasma therapies on wound healing: A Systematic Review and meta-analysis	10
Personalized tissue-engineered arteries as vascular graft transplants: A safety study in sheep	10
Prospect of 3D bioprinting over cardiac cell therapy and conventional tissue engineering in the treatment of COVID-19 patients with myocardial injury	10
Canine adipose-derived mesenchymal stromal cells inhibit the growth of canine hematologic malignancy cell lines	10
Exosome-based approaches in cancer along with unlocking new insights into regeneration of cancer-prone tissues	10
Long term observation of de novo adipogenesis using novel bioabsorbable implants with larger size in a porcine model	10
Dynamic tracking of human umbilical cord mesenchymal stem cells (hUC-MSCs) following intravenous administration in mice model	10
Nanosecond pulsed electric field applications rejuvenate aging endothelial cells by rescuing mitochondrial-to-nuclear retrograde communication	10
The phenotypic characterization of mouse floxed Fam20b chondrocytes, a novel articular cartilage-derived cell line with differentiation potential	10
Gliko BMSC: A potential strategy of treatment for renal fibrosis	10
Modified human skin cell isolation protocol and its influence on keratinocyte and melanocyte culture	10
Preface to the special issue of “Regenerative therapy”: “Future of regenerative medicine viewed by young scientists”	10
Optimal frequency of platelet-rich plasma injections for managing osteoarthritis: A longitudinal study	10
Editorial Board	10
Global research dynamics in the induced pluripotent stem cell and diabetes: A bibliometric analysis of the past twenty years	10
Transplantation of chemically induced liver progenitors in Nagase analbuminemic rats under liver regenerative stimulus	10
Retraction notice to “Preclinical assessment of transplantable human nasal mucosal epithelial cell sheets” [Regenerative Therapy 18 (2021) 59–65]	9
A comparative analysis of attitudes toward stem cell research and regenerative medicine between six countries – A pilot study	9
Tracking adipose-derived mesenchymal stromal cells in the eye: Integrating IVIS imaging and Alu PCR for enhanced detection of human cells	9
Hydrogel in musculoskeletal diseases: Unraveling trends, research foci, and future trajectories via bibliometric insights (from 2000 to 2025)	9
Spatial heterogeneity analysis of seeding of human induced pluripotent stem cells for neuroectodermal differentiation	9
Transplantation of adipose-derived stem cell aggregates via hydrogel microspheres that incorporate growth factors increases muscle strength	9
Simultaneous binding of bFGF to both FGFR and integrin maintains properties of primed human induced pluripotent stem cells	9
Clinical efficacy of invimestrocel for acute respiratory distress syndrome caused by pneumonia: Comparison with historical data using propensity score analysis	9
Cholangiocyte-derived exosomal miR-381-3p promotes hepatic stellate cell activation and cholestatic liver fibrosis via targeting Klf6	9
Platelet-rich plasma therapy for knee osteoarthritis: Insights from real-world clinical data in Japan	9
Mesenchymal stem cells: Guardians of women's health	9
MiRNA-218 inhibits cell proliferation, migration and invasion by targeting Runt-related transcription factor 2 (Runx2) in human osteosarcoma cells	9
Single-cell RNA sequencing unravels heterogeneity of skeletal progenitors and cell–cell interactions underlying the bone repair process	9
Investigating the effect of mesenchymal stem cells on the rate of clinical and pathological improvement of asthmatic lung in mouse model	9
Effect of a FOXO1 inhibitor on trophoblast differentiation from human pluripotent stem cells and ERV-associated gene expression	9
Repair of ovine peripheral nerve injuries with xenogeneic human acellular sciatic nerves prerecellularized with allogeneic Schwann-like cells—an innovative and promising approach	8

The superficial branch of the radial nerve and sensory disturbance in the radial forearm flap donor-site	8
Mesenchymal stem cell-derived extracellular vesicles/exosome: A promising therapeutic strategy for intracerebral hemorrhage	8
The NFATC2/Nrf2 cascade regulates spinal cord ischemia-reperfusion injury by controlling inflammation, apoptosis and oxidative stress	8
Corrigendum to “Salvianolic acid A facilitates cartilage repair in knee osteoarthritis model rats by promoting WDR5 expression” [Regen Therapy 29C (2025) 77–90/880]	8
Dendrobium officinale polysaccharide promotes angiogenesis as well as follicle regeneration and hair growth through activation of the WNT signaling pathway	8
Tangeretin suppresses RANKL-induced osteoclastogenesis and alleviates postmenopausal osteoporosis by inhibiting Notch signaling	8
Preventing MSC aging and enhancing immunomodulation: Novel strategies for cell-based therapies	8
Research trends on platelet-rich plasma in improving ovarian dysfunction: A bibliometric and visualization analysis	8
Mineralized collagen scaffold bone graft accelerate the osteogenic process of HASCs in proper concentration	8
Reconstitution and post-thaw storage of cryopreserved human mesenchymal stromal cells: Pitfalls and optimizations for clinically compatible formulants	8
Fabrication of Biologically Inspired Electrospun Collagen/Silk fibroin/bioactive glass composited nanofibrous scaffold to accelerate the treatment efficiency of bone repair	8
Establishment of reproducible method for production of cultured epidermal sheets with controlled melanocyte density	8
Investigating the attenuating effects of metformin-loaded selenium nanoparticles coupled with Myrtus communis L. flower extract on CaOx deposition in male Sprague Dawley rat kidneys via regulating MAP	8
Design and development of pH-responsive levofloxacin-loaded metal-organic framework for the promising treatment of pediatric abdominal wound repair	8
Association with cationized gelatin nanospheres enhances cell internalization of mitochondria efficiency	8
Generation of functional liver sinusoidal endothelial-like cells from human bone marrow-derived mesenchymal stem cells	8
Scalable production process development for NK cells targeting large-scale expansion	8
Mesenchymal stem cell therapy in ischemic stroke trials. A systematic review	8
Potential therapeutic effects and nano-based delivery systems of mesenchymal stem cells and their isolated exosomes to alleviate acute respiratory distress syndrome caused by COVID-19	8
Laminin-221-derived recombinant fragment facilitates isolation of cultured skeletal myoblasts	8
Prognostic factors affecting periodontal regenerative therapy using recombinant human fibroblast growth factor-2: A 3-year cohort study	8
Assessment of permeability in deep tissue capillaries using a new method reflects the nutrient supply status in a healthy heart	8
Nisin-preconditioned mesenchymal stem cells combatting nosocomial Pseudomonas infections	8
Inhibition of the TLR4/RAGE pathway by clearance of extracellular HMGB1 is a potential therapeutic target for radiation-damaged salivary glands	8
Role of cell-based therapies in digestive disorders: Obstacles and opportunities	8
Microbiome-derived bile acids as endogenous regenerative mediators in liver repair	8
Autologous concentrated growth factor mediated accelerated bone healing in root-end microsurgery: A multicenter randomized clinical trial	8