Genes & Diseases

Article	Citations
The Nuclear Factor Kappa B (NF-kB) signaling in cancer development and immune diseases	214
Advances in the early diagnosis of hepatocellular carcinoma	189
Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics	156
Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy	94
CCL5/CCR5 axis in human diseases and related treatments	93
Development of cell-based pseudovirus entry assay to identify potential viral entry inhibitors and neutralizing antibodies against SARS-CoV-2	80
Traditional Chinese medicine as supportive care for the management of liver cancer: Past, present, and future	73
Molecular subtypes of colorectal cancer: An emerging therapeutic opportunity for personalized medicine	69
The functions of N6-methyladenosine modification in lncRNAs	65
Enzymatic and metabolic regulation of lysine succinylation	60
Critical roles of FTO-mediated mRNA m6A demethylation in regulating adipogenesis and lipid metabolism: Implications in lipid metabolic disorders	59
Targeting angiogenesis for liver cancer: Past, present, and future	58
NADPH debt drives redox bankruptcy: SLC7A11/xCT-mediated cystine uptake as a double-edged sword in cellular redox regulation	58
Gastrointestinal symptoms, pathophysiology, and treatment in COVID-19	58
Regulation of ferroptosis in cancer cells by YAP/TAZ and Hippo pathways: The therapeutic implications	56
Alternative polyadenylation of mRNA and its role in cancer	56
Oridonin and its derivatives for cancer treatment and overcoming therapeutic resistance	54
The critical roles of m6A modification in metabolic abnormality and cardiovascular diseases	50
The clinical and immunological features of pediatric COVID-19 patients in China	50
Genomics functional analysis and drug screening of SARS-CoV-2	49
Breast and gut microbiome in health and cancer	49
Metabolic reprogramming in tumors: Contributions of the tumor microenvironment	42
Coronavirus disease 2019 (COVID-19): cytokine storms, hyper-inflammatory phenotypes, and acute respiratory distress syndrome	42
Ferroptosis: An emerging therapeutic opportunity for cancer	41
Pioglitazone ameliorates neuronal damage after traumatic brain injury via the PPARγ/NF-κB/IL-6 signaling pathway	38

Adjuvant therapies after curative treatments for hepatocellular carcinoma: Current status and prospects	36
Targeting LIF/LIFR signaling in cancer	36
Targeting RAS–RAF–MEK–ERK signaling pathway in human cancer: Current status in clinical trials	35
Microvesicles (MIVs) secreted from adipose-derived stem cells (ADSCs) contain multiple microRNAs and promote the migration and invasion of endothelial cells	34
Emerging important roles of circRNAs in human cancer and other diseases	33
Mitochondrial dysfunction: A hidden trigger of autism?	33
Tumor suppressor p53 cross-talks with TRIM family proteins	32
ITGA2 promotes expression of ACLY and CCND1 in enhancing breast cancer stemness and metastasis	32
The Hippo Tumor Suppressor Pathway (YAP/TAZ/TEAD/MST/LATS) and EGFR-RAS-RAF-MEK in cancer metastasis	32
Notch signaling: Its essential roles in bone and craniofacial development	31
Obesity as potential breast cancer risk factor for postmenopausal women	31
The mitophagy receptor FUN14 domain-containing 1 (FUNDC1): A promising biomarker and potential therapeutic target of human diseases	30
Patients with SARS-CoV-2 and HBV co-infection are at risk of greater liver injury	30
Exosomal long non-coding RNAs: Emerging players in cancer metastasis and potential diagnostic biomarkers for personalized oncology	28
Cancer: An unknown territory; rethinking before going ahead	28
Novel SARS-CoV-2 outbreak and COVID19 disease; a systemic review on the global pandemic	28
The biogenesis and secretion of exosomes and multivesicular bodies (MVBs): Intercellular shuttles and implications in human diseases	28
Characteristics and regulation of mesenchymal stem cell plasticity by the microenvironment — specific factors involved in the regulation of MSC plasticity	27
Pharmacological perspectives and molecular mechanisms of coumarin derivatives against virus disease	27
Immune checkpoint: The novel target for antitumor therapy	27
Ferroptosis as a novel form of regulated cell death: Implications in the pathogenesis, oncometabolism and treatment of human cancer	26
Study on the hepatocellular carcinoma model with metastasis	25
Emerging roles of activating transcription factor (ATF) family members in tumourigenesis and immunity: Implications in cancer immunotherapy	25
ROS and Lipid Droplet accumulation induced by high glucose exposure in healthy colon and Colorectal Cancer Stem Cells	25
Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia	25
Identification of cross-reactive CD8+ T cell receptors with high functional avidity to a SARS-CoV-2 immunodominant epitope and its natural mutant variants	24
Osteogenic and antibacterial dual functions of a novel levofloxacin loaded mesoporous silica microspheres/nano-hydroxyapatite/polyurethane composite scaffold	24
Macrophage RGS12 contributes to osteoarthritis pathogenesis through enhancing the ubiquitination	24
Functional roles of lncRNAs in the pathogenesis and progression of cancer	23
Metabolic reprogram associated with epithelial-mesenchymal transition in tumor progression and metastasis	23
SFRP5 inhibits melanin synthesis of melanocytes in vitiligo by suppressing the Wnt/β-catenin signaling	22
Promising therapeutic approaches using CRISPR/Cas9 genome editing technology in the treatment of Duchenne muscular dystrophy	22
THBS1 regulates trophoblast fusion through a CD36-dependent inhibition of cAMP, and its upregulation participates in preeclampsia	22
Reversible N6-methyladenosine of RNA: The regulatory mechanisms on gene expression and implications in physiology and pathology	21
Targeting m6A modification inhibits herpes virus 1 infection	21
Highly expressed BMP9/GDF2 in postnatal mouse liver and lungs may account for its pleiotropic effects on stem cell differentiation, angiogenesis, tumor growth and metabolism	21
Extracellular vesicles in neurodegenerative diseases: Insights and new perspectives	21
Melanoma: Molecular genetics, metastasis, targeted therapies, immunotherapies, and therapeutic resistance	20
Microbiome data analysis with applications to pre-clinical studies using QIIME2: Statistical considerations	20
RISC assembly and post-transcriptional gene regulation in Hepatocellular Carcinoma	20
The multifaceted PDCD10/CCM3 gene	20
Mettl5 mediated 18S rRNA N6-methyladenosine (m6A) modification controls stem cell fate determination and neural function	20
Inflammation and cancer: paradoxical roles in tumorigenesis and implications in immunotherapies	20
Allotopic expression of mitochondrial genes: Basic strategy and progress	19
Long noncoding RNA XIST: Mechanisms for X chromosome inactivation, roles in sex-biased diseases, and therapeutic opportunities	19
Transcriptional control by HNF-1: Emerging evidence showing its role in lipid metabolism and lipid metabolism disorders	18
miR-106b as an emerging therapeutic target in cancer	18
Therapeutic potential of TNFα inhibitors in chronic inflammatory disorders: Past and future	18
The USP7 protein interaction network and its roles in tumorigenesis	18
tRNA-derived small RNAs: Mechanisms and potential roles in cancers	17

The regulatory roles of aquaporins in the digestive system	17
Nidogen: A matrix protein with potential roles in musculoskeletal tissue regeneration	17
Discovery of a tetrahydroisoquinoline-based CDK9-cyclin T1 protein–protein interaction inhibitor as an anti-proliferative and anti-migration agent against triple-negative breast cancer cells	17
Identification of miRNA signature associated with BMP2 and chemosensitivity of TMZ in glioblastoma stem-like cells	16
Desulfovibrio desulfuricans aggravates atherosclerosis by enhancing intestinal permeability and endothelial TLR4/NF-κB pathway in Apoe mice	16
Tumor microenvironment pathways: Cross regulation in breast cancer metastasis	15
The role of distinct co-mutation patterns with TP53 mutation in immunotherapy for NSCLC	15
Long non-coding RNA (lncRNA): A potential therapeutic target in acute lung injury	15
Autophagic dysfunction of β cell dysfunction in type 2 diabetes, a double-edged sword	15
LRP1B suppresses HCC progression through the NCSTN/PI3K/AKT signaling axis and affects doxorubicin resistance	15
PIWI-interacting RNAs: Mitochondria-based biogenesis and functions in cancer	15
Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer	15
Na,K-ATPase as a target for endogenous cardiotonic steroids: What's the evidence?	15
Hypercalciuria switches Ca2+ signaling in proximal tubular cells, induces oxidative damage to promote calcium nephrolithiasis	14
Role of hormone receptors and HER2 as prospective molecular markers for breast cancer: An update	14
Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders	14
Chaperone-assisted E3 ligase CHIP: A double agent in cancer	14
Autophagy in pulmonary fibrosis: friend or foe?	14
SATB2: A versatile transcriptional regulator of craniofacial and skeleton development, neurogenesis and tumorigenesis, and its applications in regenerative medicine	14
MicroRNAs and JAK/STAT3 signaling: A new promising therapeutic axis in blood cancers	14
Cancer genes and cancer stem cells in tumorigenesis: Evolutionary deep homology and controversies	14
Oxidative stress and mitochondrial transfer: A new dimension towards ocular diseases	14
The role of dendritic cells derived osteoclasts in bone destruction diseases	14
The KiSS-1/GPR54 system: Essential roles in physiological homeostasis and cancer biology	14
Development of a multicellular 3D-bioprinted microtissue model of human periodontal ligament-alveolar bone biointerface: Towards a pre-clinical model of periodontal diseases and personalized periodont	14
The pseudogenes of eukaryotic translation elongation factors (EEFs): Role in cancer and other human diseases	14
A new emerging target in cancer immunotherapy: Galectin-9 (LGALS9)	14
Development of a simplified and inexpensive RNA depletion method for plasmid DNA purification using size selection magnetic beads (SSMBs)	14
M6A modification of circNSUN2 promotes colorectal liver metastasis	14
Suppression of a core metabolic enzyme dihydrolipoamide dehydrogenase (dld) protects against amyloid beta toxicity in C. elegans model of Alzheimer's disease	14
Calcineurin in development and disease	13
Human obstructive (postvasectomy) and nonobstructive azoospermia – Insights from scRNA-Seq and transcriptome analysis	13
Known drugs and small molecules in the battle for COVID-19 treatment	13
Role of Receptor Interacting Protein (RIP) kinases in cancer	13
Revisiting chemoresistance in ovarian cancer: Mechanism, biomarkers, and precision medicine	13
Non-small cell lung carcinoma (NSCLC): Implications on molecular pathology and advances in early diagnostics and therapeutics	13
Tetrandrine inhibits proliferation of colon cancer cells by BMP9/ PTEN/ PI3K/AKT signaling	13
Epigenetic regulation of prostate cancer	13
The study on the safety and efficacy of amnion graft for preventing the recurrence of moderate to severe intrauterine adhesions	13
PGC-1α promotes mitochondrial respiration and biogenesis during the differentiation of hiPSCs into cardiomyocytes	13
Cysteine dioxygenase type 1 (CDO1): Its functional role in physiological and pathophysiological processes	13
The fuel and engine: The roles of reprogrammed metabolism in metastasis of primary liver cancer	12
Drugging IGF-1R in cancer: New insights and emerging opportunities	12
Correlation between IL28B/TLR4 genetic variants and HCC development with/without DAAs treatment in chronic HCV patients	12
Bone morphogenetic protein 4 (BMP4) promotes hepatic glycogen accumulation and reduces glucose level in hepatocytes through mTORC2 signaling pathway	12
Modeling colorectal tumorigenesis using the organoids derived from conditionally immortalized mouse intestinal crypt cells (ciMICs)	12
Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas	12
The dark face of fructose as a tumor promoter	12
Targeting PD-1/PD-L1 in cancer immunotherapy: An effective strategy for treatment of triple-negative breast cancer (TNBC) patients	12
Metabolomic studies in the inborn error of metabolism alkaptonuria reveal new biotransformations in tyrosine metabolism	12
Development of a tRNA-derived small RNA diagnostic and prognostic signature in liver cancer	12
Cancer cell cycle heterogeneity as a critical determinant of therapeutic resistance	12
Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes	11
The recent advances and future perspectives of genetic compensation studies in the zebrafish model	11
Role of thioredoxin-interacting protein in mediating endothelial dysfunction in hypertension	11
Argonaute (AGO) proteins play an essential role in mediating BMP9-induced osteogenic signaling in mesenchymal stem cells (MSCs)	11
Ccrl2 deficiency deteriorates obesity and insulin resistance through increasing adipose tissue macrophages infiltration	11
Integrated chromatin and transcriptomic profiling of patient-derived colon cancer organoids identifies personalized drug targets to overcome oxaliplatin resistance	11
Alantolactone inhibits proliferation, metastasis and promotes apoptosis of human osteosarcoma cells by suppressing Wnt/β-catenin and MAPKs signaling pathways	11
The inflammatory microenvironment and the urinary microbiome in the initiation and progression of bladder cancer	11
Systematic analysis of clinical relevance and molecular characterization of m6A in COVID-19 patients	11
Pandemic COVID-19: Current status and challenges of antiviral therapies	11
Mechanism and effect of stress granule formation in cancer and its potential roles in breast cancer therapy	11
Single-cell landscape analysis reveals distinct regression trajectories and novel prognostic biomarkers in primary neuroblastoma	11
Pathogenic role of microRNAs in atherosclerotic ischemic stroke: Implications for diagnosis and therapy	10
Melatonin antagonizes ovarian aging via YTHDF2-MAPK-NF-κB pathway	10
The number and cytotoxicity and the expression of cytotoxicity-related molecules in peripheral natural killer (NK) cells do not predict the repeated implantation failure (RIF) for the in vitro fertili	10
Does epigenetics have a role in age related macular degeneration and diabetic retinopathy?	10
Unclear but present danger: An asymptomatic SARS-CoV-2 carrier	10
Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk	10
Twists and turns of the genetic story of mevalonate kinase-associated diseases: A review	10
PTPN18 promotes colorectal cancer progression by regulating the c-MYC-CDK4 axis	10
Adenomyosis-derived extracellular vesicles endow endometrial epithelial cells with an invasive phenotype through epithelial-mesenchymal transition	10
Reduced neutralization of SARS-CoV-2 B.1.617 variant by convalescent and vaccinated sera	10
Insulin-resistance and depression cohort data mining to identify nutraceutical related DNA methylation biomarker for type 2 diabetes	10
LncRNA KCNQ1OT1: Molecular mechanisms and pathogenic roles in human diseases	10
Defective claudin-10 causes a novel variation of HELIX syndrome through compromised tight junction strand assembly	9
Integrated analysis on transcriptome and behaviors defines HTT repeat-dependent network modules in Huntington's disease	9
The effects of nicotinamide adenine dinucleotide in cardiovascular diseases: Molecular mechanisms, roles and therapeutic potential	9
Inwardly rectifying potassium channel 5.1: Structure, function, and possible roles in diseases	9

SQSTM1/p62 regulate breast cancer progression and metastasis by inducing cell cycle arrest and regulating immune cell infiltration	9
Mesenchymal stromal cell-derived small extracellular vesicles modulate macrophage polarization and enhance angio-osteogenesis to promote bone healing	9
CircRNA expression profiles in decidual tissue of patients with early recurrent miscarriage	9
The emerging role of snoRNAs in human disease	9
The emergence of tumor-infiltrating lymphocytes in nasopharyngeal carcinoma: Predictive value and immunotherapy implications	9
Cardiac troponin I R193H mutant interacts with HDAC1 to repress phosphodiesterase 4D expression in cardiomyocytes	9
Nucleolus localization of SpyCas9 affects its stability and interferes with host protein translation in mammalian cells	9
Depression and stress levels increase risk of liver cancer through epigenetic downregulation of hypocretin	9
Biomechanical analysis of the computer-assisted internal fixation of a femoral neck fracture	9
New insight of obesity-associated NAFLD: Dysregulated “crosstalk” between multi-organ and the liver?	8
Chemerin deficiency regulates adipogenesis is depot different through TIMP1	8
Progress in hepatectomy for hepatocellular carcinoma and peri-operation management	8
Mechanism of PARP inhibitor resistance and potential overcoming strategies	8
Deregulated miRNA clusters in ovarian cancer: Imperative implications in personalized medicine	8
All-trans retinoic acid reverses malignant biological behavior of hepatocarcinoma cells by regulating miR-200 family members	8
Depletion of VPS35 attenuates metastasis of hepatocellular carcinoma by restraining the Wnt/PCP signaling pathway	8
Latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases	8
A peptide-based assay discriminates individual antibody response to SARS-CoV-2	8
Tsc2 mutation induces renal tubular cell nonautonomous disease	8
Adiponectin and metabolic cardiovascular diseases: Therapeutic opportunities and challenges	8
LPCAT1 functions as a novel prognostic molecular marker in hepatocellular carcinoma	8
Chinese herbal decoction astragalus and angelica exerts its therapeutic effect on renal interstitial fibrosis through the inhibition of MAPK, PI3K-Akt and TNF signaling pathways	8
Histone post-translational modification and the DNA damage response	8
Osteopontin inhibits osteoarthritis progression via the OPN/CD44/PI3K signal axis	8
Comparison of hepatic gene expression profiles between three mouse models of Nonalcoholic Fatty Liver Disease	8
HIF-1α signaling: Essential roles in tumorigenesis and implications in targeted therapies	8
Tetratricopeptide repeat domain 36 deficiency mitigates renal tubular injury by inhibiting TGF-β1-induced epithelial–mesenchymal transition in a mouse model of chronic kidney disease	7
MiRNAs and lncRNAs in NK cell biology and NK/T-cell lymphoma	7
Comprehensive biological function analysis of lncRNAs in hepatocellular carcinoma	7
Differential subcellular distribution renders HAI-2 a less effective protease inhibitor than HAI-1 in the control of extracellular matriptase proteolytic activity	7
lncRNA cytoskeleton regulator RNA (CYTOR): Diverse functions in metabolism, inflammation and tumorigenesis, and potential applications in precision oncology	7
Circ-Smad5 retards the G1/S transition of cell cycle via inhibiting the activity of wnt/lef/cyclind1 signaling in JB6 cells	7
The effects of repeated propofol anesthesia on spatial memory and long-term potentiation in infant rats under hypoxic conditions	7
Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer	7
Targeting UDP-α-d-glucose 6-dehydrogenase alters the CNS tumor immune microenvironment and inhibits glioblastoma growth	7
Long noncoding RNA (lncRNA) H19: An essential developmental regulator with expanding roles in cancer, stem cell differentiation, and metabolic diseases	7
Pathogenesis of premature coronary artery disease: Focus on risk factors and genetic variants	7
MiR-743a-5p regulates differentiation of myoblast by targeting Mob1b in skeletal muscle development and regeneration	7
Ubiquitin-specific peptidase 18 regulates the differentiation and function of Treg cells	7
The SUMO E3 ligase CBX4 is identified as a poor prognostic marker of gastric cancer through multipronged OMIC analyses	7
Phenotypic characterization of patients with activated PI3Kδ syndrome 1 presenting with features of systemic lupus erythematosus	7
Sulfuretin exerts diversified functions in the processing of amyloid precursor protein	7
Advances in oral mesenchymal stem cell-derived extracellular vesicles in health and disease	7
Targeting fructose metabolism by glucose transporter 5 regulation in human cholangiocarcinoma	7
All-trans retinoic acid inhibits the malignant behaviors of hepatocarcinoma cells by regulating ferroptosis	7
Histidine-rich glycoprotein (HRGP): Pleiotropic and paradoxical effects on macrophage, tumor microenvironment, angiogenesis, and other physiological and pathological processes	7
ARHGEF38 as a novel biomarker to predict aggressive prostate cancer	7
Estrogen deficiency exacerbates learning and memory deficits associated with glucose metabolism disorder in APP/PS1 double transgenic female mice	7
Liver-specific Mettl3 ablation delays liver regeneration in mice	7
Pancreatic stromal Gremlin 1 expression during pancreatic tumorigenesis	7
Clinical relevance of circulating non-coding RNAs in metabolic diseases: Emphasis on obesity, diabetes, cardiovascular diseases and metabolic syndrome	7
Masks and thermometers: Paramount measures to stop the rapid spread of SARS-CoV-2 in the United States	7
High-throughput 16S rDNA sequencing of the pulmonary microbiome of rats with allergic asthma	6
ANO5-related muscle diseases: From clinics and genetics to pathology and research strategies	6
Crosstalk between the B7/CD28 and EGFR pathways: Mechanisms and therapeutic opportunities	6
Weakened humoral and cellular immune response to the inactivated COVID-19 vaccines in Chinese individuals with obesity/overweight	6
Salivary microbiota may predict the presence of esophageal squamous cell carcinoma	6
Defective EMC1 drives abnormal retinal angiogenesis via Wnt/β-catenin signaling and may be associated with the pathogenesis of familial exudative vitreoretinopathy	6
Integrated bioinformatics identifies the dysregulation induced by aberrant gene methylation in colorectal carcinoma	6
Adverse effects of chemoradiotherapy on invasion and metastasis of tumor cells	6
The link between intracellular calcium signaling and exosomal PD-L1 in cancer progression and immunotherapy	6
VPS33B suppresses lung adenocarcinoma metastasis and chemoresistance to cisplatin	6
Helicobacter pylori isolated from gastric juice have higher pathogenic potential than biopsy isolates	6
Application and progress of the detection technologies in hepatocellular carcinoma	6
The function and mechanism of lactate and lactylation in tumor metabolism and microenvironment	6
The essential role of N6-methyladenosine RNA methylation in complex eye diseases	6
Dynamic m6A-ncRNAs association and their impact on cancer pathogenesis, immune regulation and therapeutic response	6
WNT/β-catenin signaling in hepatocellular carcinoma: The aberrant activation, pathogenic roles, and therapeutic opportunities	6
PGRN exacerbates the progression of non-small cell lung cancer via PI3K/AKT/Bcl-2 antiapoptotic signaling	6
Clinical applications of the CRISPR/Cas9 genome-editing system: Delivery options and challenges in precision medicine	6
Long non-coding RNA HCAR promotes endochondral bone repair by upregulating VEGF and MMP13 in hypertrophic chondrocyte through sponging miR-15b-5p	6
CNTs mediated CD44 targeting; a paradigm shift in drug delivery for breast cancer	6
Metformin ameliorates HMGB1-mediated oxidative stress through mTOR pathway in experimental periodontitis	6
Abatacept is effective in Chinese patients with LRBA and CTLA4 deficiency	6
Downregulation of nc886 contributes to prostate cancer cell invasion and TGFβ1-induced EMT	6
Mechanisms of NLRP3 inflammasome-mediated hepatic stellate cell activation: Therapeutic potential for liver fibrosis	6
The functional role of Higd1a in mitochondrial homeostasis and in multiple disease processes	6
PRR11 induces filopodia formation and promotes cell motility via recruiting ARP2/3 complex in non-small cell lung cancer cells	6
Whole-exome mutational landscape of metastasis in patient-derived hepatocellular carcinoma cells	6
Identification of rare PTCH1 nonsense variant causing orofacial cleft in a Chinese family and an up-to-date genotype-phenotype analysis	6
Protective effects of IRG1/itaconate on acute colitis through the inhibition of gasdermins-mediated pyroptosis and inflammation response	6