OOIR: Observatory of International Research

Papers

(The H4-Index of Genes & Diseases is 33. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
A patient with glycogen storage disease type IA combined with hepatic adenoma: A case report	465
C-terminal tensin-like (CTEN) knockin alleviates cystic kidney defects in Tensin-1 knockout mice	266
Identification of differently expressed mRNAs by peripheral blood mononuclear cells in Vogt-Koyanagi-Harada disease	166
Ubiquitination and degradation of SIK2 by DNA-PKcs deficiency promote radiation-induced mitotic catastrophe	147
Loss of the emei tumor suppressor promotes tumorigenesis via the JNK and Hippo pathway	87
Identifying functional subtypes and common mechanisms of rheumatoid arthritis and systemic lupus erythematosus	85
Synergistic anti-tumor activity of ciclopirox olamine and metformin in triple-negative breast cancer	79
The same genomic variants in the first three exons of KANSL1 can be either benign or causative of Koolen-de Vries syndrome: Definition of a validation procedure	75
The molecular genetics of PI3K/PTEN/AKT/mTOR pathway in the malformations of cortical development	70
Ferroptosis: An emerging therapeutic opportunity for cancer	67
BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response	64
CD36 promotes tubular ferroptosis by regulating the ubiquitination of FSP1 in acute kidney injury	62
LncRNA HOTTIP facilitated tumor growth via stimulating the hnRNPA2B1/DKK1/Wnt/β-catenin regulatory axis in hepatocellular carcinoma	55
Prevention and treatment of gerbil hepatitis E using the programmable CRISPR-Cas13d system	53
DNA damage chemotherapeutic drugs suppress basal-like breast cancer growth by down-regulating the transcription of the FOXO1-KLF5 axis	52
Aquaporin-3 promotes proliferation and inflammation in hepatocellular carcinoma	52
SFRP5 inhibits melanin synthesis of melanocytes in vitiligo by suppressing the Wnt/β-catenin signaling	51
Development of an orally bioavailable selective inhibitor of the menin-MLL	48
Liver-specific Mettl3 ablation delays liver regeneration in mice	48
Transcriptomic analysis reveals the promotion of lymph node metastasis by Helicobacter pylori infection via upregulating chemokine (C-X-C motif) receptor 2 expression in gastric carcinoma	47
The transcriptome of circulating cells indicates potential biomarkers and therapeutic targets in the course of hypertension-related myocardial infarction	43
A novel structural variant of RET causes familial Hirschsprung's disease via nonsense-mediated mRNA decay	42
PTEN-induced putative kinase 1 regulates mitochondrial quality control and is essential for the maturation of human induced pluripotent stem cell-derived cardiomyocytes	41
Etiological roles of core promoter variation in triple-negative breast cancer	39
Identification of rare PTCH1 nonsense variant causing orofacial cleft in a Chinese family and an up-to-date genotype-phenotype analysis	38

Does burning fat make tumor immune hot? Discovery of CD47 overexpression by radiation induced fatty acid oxidation	37
With newer tools for gene editing, is it time to revisit genetic therapy for cystic fibrosis?	37
Integrative analysis of the transcriptome and metabolome reveals the importance of hepatokine FGF21 in liver aging	36
Coupled single-cell and bulk RNA-seq analysis reveals the engulfment role of endothelial cells in atherosclerosis	36
Post-transcriptional regulation of DEAD-box RNA helicases in hematopoietic malignancies	36
Multi-omics analysis to identify CBR3-AS1-hsa-miR-145-5p-MAP3K5 pathway as a ferroptosis-related ceRNA network in benign prostatic hyperplasia	35
MAL2 DNA methylation serves as a biomarker for the diagnosis and prognosis of glioma	33
Epigenetics: Mechanisms, potential roles, and therapeutic strategies in cancer progression	33
PDCD2 as a prognostic biomarker in glioma correlates with malignant phenotype	33
The landscape of epigenetic regulation and therapeutic application of N6-methyladenosine modifications in non-coding RNAs	33