OOIR: Observatory of International Research

Papers

(The H4-Index of Genes & Diseases is 47. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
PTEN-induced putative kinase 1 regulates mitochondrial quality control and is essential for the maturation of human induced pluripotent stem cell-derived cardiomyocytes	1536
Deletion of Axin1 in aggrecan-expressing cells leads to growth plate cartilage defects in adult mice	237
An in-depth analysis of the prognostic significance and potential clinical impact of Leupaxin in the immunotherapeutic treatment of esophageal squamous cell carcinoma	188
Liver-brain axis with alcohol: Role of fibroblast growth factor 21 (FGF21)	185
Atm deficient zebrafish model reveals conservation of the tumour suppressor function and a role in fertility	167
CCDC178-mediated cytoskeleton assembly is required for spermiogenesis in mice	141
Autoantigenic peptide landscape of rheumatoid arthritis-associated HLA class II	122
Perturbed microbial ecology in pediatric systemic lupus erythematosus: Evidence from the gut microbiome and serum metabolome	122
Development of an orally bioavailable selective inhibitor of the menin-MLL	121
Expanded insights into the mechanisms of RNA-binding protein regulation of circRNA generation and function in cancer biology and therapy	111
Exploring the role of FTO in preeclampsia pathogenesis: Insights into m6A modification and decidualization	109
Integrating single-cell transcriptomics and machine learning to reveal prognostic and immune significance of lactylation in breast cancer	107
Tryptophan attenuates acute hypoxic stress-induced intestinal injury through the modulation of intestinal barrier integrity and gut microbiota homeostasis	105
Inflammasome activation and signalling in the ischemic-reperfused myocardium	105
Optimized Yamanaka factors combined with TERT gene therapy for enhanced anti-aging effects	102
lncRNA cytoskeleton regulator RNA (CYTOR): Diverse functions in metabolism, inflammation and tumorigenesis, and potential applications in precision oncology	98
SETDB1-mediated CD147-K71 di-methylation promotes cell apoptosis in non-small cell lung cancer	93
Macrophage RGS12 contributes to osteoarthritis pathogenesis through enhancing the ubiquitination	91
Ubiquitination and degradation of SIK2 by DNA-PKcs deficiency promote radiation-induced mitotic catastrophe	80
The implication of pyroptosis in cancer immunology: Current advances and prospects	78
SLC27A5 inhibits cancer stem cells by inducing alternative polyadenylation of METTL14 in hepatocellular carcinoma	77
Multi-omics analysis to identify CBR3-AS1-hsa-miR-145-5p-MAP3K5 pathway as a ferroptosis-related ceRNA network in benign prostatic hyperplasia	77
DNA damage chemotherapeutic drugs suppress basal-like breast cancer growth by down-regulating the transcription of the FOXO1-KLF5 axis	74
Phase separation of Snail1 modulates transcription and cancer progression	72
The molecular genetics of PI3K/PTEN/AKT/mTOR pathway in the malformations of cortical development	71

Effects of extracellular vesicle-derived noncoding RNAs on pre-metastatic niche and tumor progression	70
Discovery of a tetrahydroisoquinoline-based CDK9-cyclin T1 protein–protein interaction inhibitor as an anti-proliferative and anti-migration agent against triple-negative breast cancer cells	70
Wnt genes in colonic polyposis predisposition	70
Clinical management of a rare melanoma case arising from congenital melanocytic nevus	68
Mechanism of PARP inhibitor resistance and potential overcoming strategies	68
Epigenetics: Mechanisms, potential roles, and therapeutic strategies in cancer progression	68
Patient-derived xenograft models: Current status, challenges, and innovations in cancer research	61
The role of TGF-β in the tumor microenvironment of pancreatic cancer	61
BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response	60
Regulation of SLC7A11 as an unconventional checkpoint in tumorigenesis through ferroptosis	59
The advancements in organoids: Potential and challenges in researching the esophagus and esophageal squamous cell carcinoma	58
Loss of homeostatic functions in microglia from a murine model of Friedreich's ataxia	57
Integrated bulk and single-cell transcriptome data identify clinically relevant cell populations in clear cell renal cell carcinoma	54
Disulfidptosis heterogeneity in breast cancer uncovers PTTG1IP as an actionable therapeutic target	52
Alternative splicing of immune-related genes identifies breast cancer subtypes with differential immune cell infiltration	51
AAV6 as an effective gene delivery vector for prolonged transgene expression in intervertebral disc cells in vivo	50
BET in hematologic tumors: Immunity, pathogenesis, clinical trials and drug combinations	49
Histone modifications in cardiovascular diseases: Mechanisms and therapies	49
Single-cell landscape analysis reveals distinct regression trajectories and novel prognostic biomarkers in primary neuroblastoma	48
Screening and validation of key metastasis-associated genes in pancreatic cancer using a multi-omics and machine learning approach	48
FAM151A inhibits hepatitis B virus by modulating cccDNA transcriptional activity	48
PD-L1 expression and smoke exposure as biomarkers for optimizing adjuvant therapy for patients with resected limited-stage small-cell lung carcinoma	47
HBV sL13H mutation impairs its surface antigen expression and ability to induce autophagy	47