OOIR: Observatory of International Research

Papers

(The H4-Index of Genes & Diseases is 48. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
PTEN-induced putative kinase 1 regulates mitochondrial quality control and is essential for the maturation of human induced pluripotent stem cell-derived cardiomyocytes	1642
Deletion of Axin1 in aggrecan-expressing cells leads to growth plate cartilage defects in adult mice	251
An in-depth analysis of the prognostic significance and potential clinical impact of Leupaxin in the immunotherapeutic treatment of esophageal squamous cell carcinoma	202
Liver-brain axis with alcohol: Role of fibroblast growth factor 21 (FGF21)	197
Atm deficient zebrafish model reveals conservation of the tumour suppressor function and a role in fertility	185
CCDC178-mediated cytoskeleton assembly is required for spermiogenesis in mice	153
Perturbed microbial ecology in pediatric systemic lupus erythematosus: Evidence from the gut microbiome and serum metabolome	133
Development of an orally bioavailable selective inhibitor of the menin-MLL	132
Exploring the role of FTO in preeclampsia pathogenesis: Insights into m6A modification and decidualization	130
Integrating single-cell transcriptomics and machine learning to reveal prognostic and immune significance of lactylation in breast cancer	129
Inflammasome activation and signalling in the ischemic-reperfused myocardium	118
Macrophage RGS12 contributes to osteoarthritis pathogenesis through enhancing the ubiquitination	114
Optimized Yamanaka factors combined with TERT gene therapy for enhanced anti-aging effects	114
Up-regulated IL-36 expression promotes a pro-tumorigenic phenotype in pancreatic ductal adenocarcinoma	109
Multi-omics analysis to identify CBR3-AS1-hsa-miR-145-5p-MAP3K5 pathway as a ferroptosis-related ceRNA network in benign prostatic hyperplasia	106
SLC27A5 inhibits cancer stem cells by inducing alternative polyadenylation of METTL14 in hepatocellular carcinoma	95
Phase separation of Snail1 modulates transcription and cancer progression	86
Effects of extracellular vesicle-derived noncoding RNAs on pre-metastatic niche and tumor progression	86
Discovery of a tetrahydroisoquinoline-based CDK9-cyclin T1 protein–protein interaction inhibitor as an anti-proliferative and anti-migration agent against triple-negative breast cancer cells	83
Wnt genes in colonic polyposis predisposition	83
UCH-L1 down-regulates HER2 expression and increases lapatinib sensitivity by interacting with HSP90 in HER2-positive breast cancer	82
The advancements in organoids: Potential and challenges in researching the esophagus and esophageal squamous cell carcinoma	79
Clinical management of a rare melanoma case arising from congenital melanocytic nevus	79
BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response	79
The molecular genetics of PI3K/PTEN/AKT/mTOR pathway in the malformations of cortical development	78

DNA damage chemotherapeutic drugs suppress basal-like breast cancer growth by down-regulating the transcription of the FOXO1-KLF5 axis	77
The role of TGF-β in the tumor microenvironment of pancreatic cancer	75
Ubiquitination and degradation of SIK2 by DNA-PKcs deficiency promote radiation-induced mitotic catastrophe	74
lncRNA cytoskeleton regulator RNA (CYTOR): Diverse functions in metabolism, inflammation and tumorigenesis, and potential applications in precision oncology	73
Autoantigenic peptide landscape of rheumatoid arthritis-associated HLA class II	71
Post-translational modifications of influenza virus proteins	66
Impaired neuronal migration of a novel missense variant p.Ile383Val in STXBP1 is potentially relevant to cerebral palsy	65
Epigenetics: Mechanisms, potential roles, and therapeutic strategies in cancer progression	63
Mechanism of PARP inhibitor resistance and potential overcoming strategies	61
Expanded insights into the mechanisms of RNA-binding protein regulation of circRNA generation and function in cancer biology and therapy	58
Patient-derived xenograft models: Current status, challenges, and innovations in cancer research	57
The implication of pyroptosis in cancer immunology: Current advances and prospects	55
Tryptophan attenuates acute hypoxic stress-induced intestinal injury through the modulation of intestinal barrier integrity and gut microbiota homeostasis	54
Intra-tumoral microbiota: Key modulators of tumor immunity and therapeutic potential	53
Regulation of SLC7A11 as an unconventional checkpoint in tumorigenesis through ferroptosis	52
Loss of homeostatic functions in microglia from a murine model of Friedreich's ataxia	51
SETDB1-mediated CD147-K71 di-methylation promotes cell apoptosis in non-small cell lung cancer	51
Integrated bulk and single-cell transcriptome data identify clinically relevant cell populations in clear cell renal cell carcinoma	50
Histone modifications in cardiovascular diseases: Mechanisms and therapies	49
Screening and validation of key metastasis-associated genes in pancreatic cancer using a multi-omics and machine learning approach	49
Alternative splicing of immune-related genes identifies breast cancer subtypes with differential immune cell infiltration	49
FAM151A inhibits hepatitis B virus by modulating cccDNA transcriptional activity	49
Disulfidptosis heterogeneity in breast cancer uncovers PTTG1IP as an actionable therapeutic target	49
Single-cell landscape analysis reveals distinct regression trajectories and novel prognostic biomarkers in primary neuroblastoma	48