OOIR: Observatory of International Research

Papers

(The H4-Index of Genes & Diseases is 33. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
The Nuclear Factor Kappa B (NF-kB) signaling in cancer development and immune diseases	207
Advances in the early diagnosis of hepatocellular carcinoma	178
Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics	140
Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy	88
CCL5/CCR5 axis in human diseases and related treatments	87
Development of cell-based pseudovirus entry assay to identify potential viral entry inhibitors and neutralizing antibodies against SARS-CoV-2	80
Traditional Chinese medicine as supportive care for the management of liver cancer: Past, present, and future	71
Molecular subtypes of colorectal cancer: An emerging therapeutic opportunity for personalized medicine	66
The functions of N6-methyladenosine modification in lncRNAs	64
Targeting angiogenesis for liver cancer: Past, present, and future	58
Gastrointestinal symptoms, pathophysiology, and treatment in COVID-19	56
NADPH debt drives redox bankruptcy: SLC7A11/xCT-mediated cystine uptake as a double-edged sword in cellular redox regulation	55
Regulation of ferroptosis in cancer cells by YAP/TAZ and Hippo pathways: The therapeutic implications	55
Enzymatic and metabolic regulation of lysine succinylation	55
Oridonin and its derivatives for cancer treatment and overcoming therapeutic resistance	54
Alternative polyadenylation of mRNA and its role in cancer	54
Critical roles of FTO-mediated mRNA m6A demethylation in regulating adipogenesis and lipid metabolism: Implications in lipid metabolic disorders	53
The clinical and immunological features of pediatric COVID-19 patients in China	50
Genomics functional analysis and drug screening of SARS-CoV-2	49
Breast and gut microbiome in health and cancer	48
The critical roles of m6A modification in metabolic abnormality and cardiovascular diseases	47
Metabolic reprogramming in tumors: Contributions of the tumor microenvironment	42
Coronavirus disease 2019 (COVID-19): cytokine storms, hyper-inflammatory phenotypes, and acute respiratory distress syndrome	42
Ferroptosis: An emerging therapeutic opportunity for cancer	40
Genetics of severe combined immunodeficiency	39

Pioglitazone ameliorates neuronal damage after traumatic brain injury via the PPARγ/NF-κB/IL-6 signaling pathway	38
An update on the genetics and pathogenesis of hereditary angioedema	38
Recent advances in chronic granulomatous disease	37
Adjuvant therapies after curative treatments for hepatocellular carcinoma: Current status and prospects	34
Targeting LIF/LIFR signaling in cancer	34
Microvesicles (MIVs) secreted from adipose-derived stem cells (ADSCs) contain multiple microRNAs and promote the migration and invasion of endothelial cells	34
Emerging important roles of circRNAs in human cancer and other diseases	33
Recent advances in elucidating the genetics of common variable immunodeficiency	33
Targeting RAS–RAF–MEK–ERK signaling pathway in human cancer: Current status in clinical trials	33
Mitochondrial dysfunction: A hidden trigger of autism?	33