OOIR: Observatory of International Research

Papers

(The H4-Index of Genes & Diseases is 39. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
PTEN-induced putative kinase 1 regulates mitochondrial quality control and is essential for the maturation of human induced pluripotent stem cell-derived cardiomyocytes	712
lncRNA cytoskeleton regulator RNA (CYTOR): Diverse functions in metabolism, inflammation and tumorigenesis, and potential applications in precision oncology	344
Effects of extracellular vesicle-derived noncoding RNAs on pre-metastatic niche and tumor progression	226
BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response	203
Sex hormone-binding globulin impedes hepatocellular carcinoma growth via MERTK regulation	103
Ubiquitination and degradation of SIK2 by DNA-PKcs deficiency promote radiation-induced mitotic catastrophe	101
Multi-omics analysis to identify CBR3-AS1-hsa-miR-145-5p-MAP3K5 pathway as a ferroptosis-related ceRNA network in benign prostatic hyperplasia	100
Atm deficient zebrafish model reveals conservation of the tumour suppressor function and a role in fertility	88
Clinical management of a rare melanoma case arising from congenital melanocytic nevus	82
Phenotypic characterization of patients with activated PI3Kδ syndrome 1 presenting with features of systemic lupus erythematosus	81
CCDC178-mediated cytoskeleton assembly is required for spermiogenesis in mice	79
Development of an orally bioavailable selective inhibitor of the menin-MLL	77
Patient-derived xenograft models: Current status, challenges, and innovations in cancer research	76
Deletion of Axin1 in aggrecan-expressing cells leads to growth plate cartilage defects in adult mice	72
Regulation of SLC7A11 as an unconventional checkpoint in tumorigenesis through ferroptosis	71
The implication of pyroptosis in cancer immunology: Current advances and prospects	70
Liver-brain axis with alcohol: Role of fibroblast growth factor 21 (FGF21)	65
The molecular genetics of PI3K/PTEN/AKT/mTOR pathway in the malformations of cortical development	64
Wnt genes in colonic polyposis predisposition	63
Tryptophan attenuates acute hypoxic stress-induced intestinal injury through the modulation of intestinal barrier integrity and gut microbiota homeostasis	62
Epigenetics: Mechanisms, potential roles, and therapeutic strategies in cancer progression	61
DNA damage chemotherapeutic drugs suppress basal-like breast cancer growth by down-regulating the transcription of the FOXO1-KLF5 axis	61
Mechanism of PARP inhibitor resistance and potential overcoming strategies	60
Discovery of a tetrahydroisoquinoline-based CDK9-cyclin T1 protein–protein interaction inhibitor as an anti-proliferative and anti-migration agent against triple-negative breast cancer cells	59
SETDB1-mediated CD147-K71 di-methylation promotes cell apoptosis in non-small cell lung cancer	54

Macrophage RGS12 contributes to osteoarthritis pathogenesis through enhancing the ubiquitination	51
The role of TGF-β in the tumor microenvironment of pancreatic cancer	50
The biological roles and molecular mechanisms of m6A reader IGF2BP1 in the hallmarks of cancer	48
Haplotype-resolved assemblies of the MHC region in five widely used tumor cell lines	47
Development of a multicellular 3D-bioprinted microtissue model of human periodontal ligament-alveolar bone biointerface: Towards a pre-clinical model of periodontal diseases and personalized periodont	47
Overactivation of histone deacetylases and EZH2 in Wilms tumorigenesis	47
Dynamic human retinal pigment epithelium (RPE) and choroid architecture based on single-cell transcriptomic landscape analysis	46
MACF1 deficiency suppresses tooth mineralization through IGF1 mediated crosstalk between odontoblasts and ameloblasts	46
LncRNA KCNQ1OT1: Molecular mechanisms and pathogenic roles in human diseases	45
BET in hematologic tumors: Immunity, pathogenesis, clinical trials and drug combinations	43
The miR-21-5p enriched in the apoptotic bodies of M2 macrophage-derived extracellular vesicles alleviates osteoarthritis by changing macrophage phenotype	42
The USP7 protein interaction network and its roles in tumorigenesis	40
Integrated bulk and single-cell transcriptome data identify clinically relevant cell populations in clear cell renal cell carcinoma	40
The transcriptional regulators of virulence for Pseudomonas aeruginosa: Therapeutic opportunity and preventive potential of its clinical infections	40
PD-L1 expression and smoke exposure as biomarkers for optimizing adjuvant therapy for patients with resected limited-stage small-cell lung carcinoma	39
A peptide-based assay discriminates individual antibody response to SARS-CoV-2	39
AAV6 as an effective gene delivery vector for prolonged transgene expression in intervertebral disc cells in vivo	39