Cancer Immunology Research

Article	Citations
A Sampling of Highlights from the Literature	165
Abstract A022: Therapeutic inhibition of TREX1 elicits type I interferon–mediated antitumor immunity with minimal autoimmune toxicity	113
Abstract A018: Targeting PTPN1/PTPN2 with KQ-791 enhances NK cell cytotoxicity during tumor rechallenge	107
Abstract B002: Meta-Analysis of Neoantigens: Insights from the Cancer Epitope Database and Analysis Resource (CEDAR)	103
Abstract PR-10: Leveraging peripheral leukocyte recruitment to improve efficacy and mitigate toxicities following checkpoint blockade	87
Combination Therapy Approaches to Enhance the Efficacy of ERV-Targeting Vaccines in Cancer	82
Host Interactions with Engineered T-cell Micropharmacies	77
Exercise as an Immune Boost: Mechanism-Driven Support for Lifestyle Interventions	72
IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8+ T cells Infiltrating Pancreatic Ductal Adenocarcinoma	71
Optimal Neoantigen Cancer Vaccines Target CD8+ and CD4+ T Cells with Multiple Antigens	70
Correction: Inflammation Mediated by Gut Microbiome Promotes Immune Suppression and Lung Adenocarcinoma Progression	68
Self-Renewing CD8+ T-cell Abundance in Blood Associates with Response to Immunotherapy	58
Abstract LB-C008: Replication stress coupled to cGAS–STING activation defines an innate immune–inflamed transcriptional state in head and neck squamous cell carcinoma that Is enriched for HPV-positive	55
Abstract LB-C012: Immune-Like Circulating Tumor Cells and Large Extracellular Vesicles in Metastatic Breast Cancer	54
Abstract LB-C011: Using Organoids and Tumor Infiltrating Lymphocytes to Elucidate the ”Dark Matter” of Human Tumor Antigens	53
Abstract LB-A006: Impact of pharmacokinetic profiles on the in vivo antitumor efficacy of EHMT2 inhibitors combined with immune checkpoint blockade	53
Abstract LB-A013: Tuning TCR immunotherapy targeting prostatic acid phosphatase via catch bond modifications for advanced prostate cancer	53
IL18 at the Crossroads between Chronic Inflammation and T-cell Exhaustion in Pancreatic Cancer	52
Abstract A046: Dendritic cell dysfunction predicts adverse prognosis in high-risk acute lymphoblastic leukemia	51
The ω-3 Polyunsaturated Fatty Acid Docosahexaenoic Acid Enhances NK-Cell Antitumor Effector Functions	51
Abstract A028: Combination therapy with a TCR Vβ-directed bifunctional molecule, cisplatin and anti-PD-1 promotes antitumor activity in immune checkpoint blockade-refractory head and neck murine tumor	50
Abstract A041: LAG-3 is associated with poor prognosis and LAG-3 blockade enhances the efficacy of PD-1 blockade combined with radiation therapy in breast cancer	50
Abstract C070: Targeting neoantigens conserved across organs and species overcomes tumor immune escape	48
Abstract B035: Antibody-lectin chimeras for glyco-immune checkpoint blockade	47
Single-Cell Analysis of Posttranslational Modifications Identifies Immunosuppressive Macrophage Subtypes in the HBV-Positive Hepatocellular Carcinoma Microenvironment	46

Reciprocal Interactions Between the Gut Microbiome and Mammary Tissue Mast Cells Promote Metastatic Dissemination of HR+ Breast Tumors	45
Different PD-L1 Assays Reveal Distinct Immunobiology and Clinical Outcomes in Urothelial Cancer	45
CLN-617 Retains IL2 and IL12 in Injected Tumors to Drive Robust and Systemic Immune-Mediated Antitumor Activity	45
T-cell Senescence in the Tumor Microenvironment	43
A Population of TIM4+FOLR2+ Macrophages Localized in Tertiary Lymphoid Structures Correlates to an Active Immune Infiltrate Across Several Cancer Types	43
Transforming the Dark into Light: A Siglec-9 Switch	42
Preclinical Characterization and Phase I Study of an Anti–HER2-TLR7 Immune-Stimulator Antibody Conjugate in Patients with HER2+ Malignancies	42
A Sampling of Highlights from the Literature	40
Engineering CD20 CARs with a Twist	40
Low TCR Binding Strength Results in Increased Progenitor-like CD8+ Tumor-Infiltrating Lymphocytes	40
A Sampling of Highlights from the Literature	40
High Mobility Group Protein B1 Decreases Surface Localization of PD-1 to Augment T-cell Activation	39
Evaluation of Proton Minibeam Radiotherapy on Antitumor Immune Responses in a Rat Model of Glioblastoma	37
A Universal Boosting Strategy for Adoptive T-cell Therapy Using a Paired Vaccine/Chimeric Antigen Receptor	36
Circulating Neoantigen- and Viral Oncoprotein–Specific CD8+ T Cells Share a Transcriptional Signature	35
Harnessing Microbiota to Improve Immunotherapy for Gastrointestinal Cancers	35
Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity	34
Profiling Multiple CD8+ T-cell Functional Dimensions Enhances Breast Cancer Immune Assessment	33
Cannabidiol Enhances Atezolizumab Efficacy by Upregulating PD-L1 Expression via the cGAS–STING Pathway in Triple-Negative Breast Cancer Cells	33
The HSP90 Inhibitor Pimitespib Targets Regulatory T Cells in the Tumor Microenvironment	32
Identification and Phenotypic Characterization of Neoantigen-Specific Cytotoxic CD4+ T Cells in Endometrial Cancer	32
Ethnicity, Immunity, and Outcomes: Biology versus Socioeconomic Status	32
Abstract C032: Comparison of genomic drivers and transcriptomic features of immunogenicity in pancreatic malignancies	31
Abstract B024: The clinical benefit from treatment of advanced MSS mCRC with the adenosine 2a/2b antagonist etrumadenant is associated with adenosine-mediated T-cell exclusion and enhancement of the e	31
Abstract A062: Endometriosis as a Neuroimmune Disorder: Integrating Inflammation, Innervation, and Sensitization	30
Abstract B058: Longitudinal single cell and TCRβ profiling of a melanoma patient during adjuvant immune checkpoint inhibitor therapy exhibits significant change in immune cell profiles	30
Abstract A042: Onco-fetal immune tolerance factors shape T cell exhaustion and immune evasion in pregnancy and cancer	30
Abstract B005: Harnessing GD2-CAR macrophages to target high-risk neuroblastoma	29
Abstract A061: First-in-human hapten-enhanced stressed-ghost cell immunotherapy (STC-1010) for advanced colorectal cancer: preclinical and early clinical data	29
Abstract A075: Molecular glues activate immunoproteasomes to amplify and expand the MHC-class-I immunopeptidome that promotes TCR-engineered T-cell cytotoxic activity against multiple myeloma	29
Abstract A031: Systemic Inflammatory Biomarkers and Lu-177-PSMA Radiopharmaceutical Therapy Response in Sipuleucel-T-Pretreated Metastatic Castration-Resistant Prostate Cancer	29
Abstract A074: Immune dysregulation and B-cell fitness driven by PLCγ2 R665W: Insights from a novel conditional B-cell mouse model	28
Abstract B074: Killing cancer cells by suicidal bombing attack with neutrophil extracellular traps	27
CLK1 Promotes Myeloid-Derived Suppressor Cell Trafficking and Reprograms the Tumor Microenvironment by Activating Hippo/YAP Signaling in Colorectal Cancer	27
Abstract C066: Matrix-M adjuvant – A promising adjuvant for preventative and therapeutic cancer vaccines development	27
Abstract LB-B005: No effect of the time-of-day infusion of adjuvant pembrolizumab in the outcomes of patients with resectable melanoma in the NCI/SWOG trial S1404	26
KDM5A Inhibits Antitumor Immune Responses Through Downregulation of the Antigen-Presentation Pathway in Ovarian Cancer	26
Sensory Nerves Impede the Formation of Tertiary Lymphoid Structures and Development of Protective Antimelanoma Immune Responses	26
Antibody-Mediated Inhibition of HLA/LILR Interactions Breaks Innate Immune Tolerance and Induces Antitumor Immunity	26
High Expression of MHC Class I Overcomes Cancer Immunotherapy Resistance Due to IFNγ Signaling Pathway Defects	26
Ncoa2 Promotes CD8+ T cell–Mediated Antitumor Immunity by Stimulating T-cell Activation via Upregulation of PGC-1α Critical for Mitochondrial Function	26
FOXM1-specific TCR-engineered T cells target non-small cell lung cancer	26
Loss of miR-29a/b1 cluster reprograms the tumor microenvironment and contributes to immunosuppression in lung cancer	26
SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma	26
Abstract LB-B013: Eight-Pathway transcriptomic biomarker outperforms PD-L1 for anti-PD-1 response prediction in melanoma	26
A Sampling of Highlights from the Literature	25
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission	25
About the Rising Star	25
Abstract A045: Overcoming platelet-mediated immune suppression in ovarian cancer	24
Abstract C021: Cryo-Immune Vaccination (CIV): A locoregional device/multidrug immunotherapeutic approach that can bypass toxicity yet systemically eradicate metastatic cancers	24

Circulating and Intratumoral Immune Determinants of Response to Atezolizumab plus Bevacizumab in Patients with Variant Histology or Sarcomatoid Renal Cell Carcinoma	24
PIKfyve Inhibition Induces Antitumor Immunogenicity by Attenuating STING Trafficking and Lysosomal Degradation	24
Abstract C062: Tryptophan degradation by intestinal Bacteroides induces anti-tumor immunity and limits melanoma growth	24
Pseudomonas aeruginosa Exacerbates Bladder Cancer Progression by Activating Cancer-Driven Immunosuppression	24
Acknowledgment to Reviewers	24
Abstract B018: Sphingomyelin-derived nanovesicles for the delivery of the IDO1 inhibitor epacadostat enhance metastatic and post-surgical melanoma immunotherapy	24
Abstract A012: Cancer acquires therapy resistance by converting immune infiltration to exclusion through NK cell-macrophage interactions	24
Tumor-Associated CD19+CD39− B Regulatory Cells Deregulate Class-Switch Recombination to Suppress Antibody Responses	24
Denosumab Enhances Antitumor Immunity by Suppressing SPP1 and Boosting Cytotoxic T Cells	23
Spatial Organization of Macrophages in CTL-Rich Hepatocellular Carcinoma Influences CTL Antitumor Activity	23
Setdb1 Loss Induces Type I Interferons and Immune Clearance of Melanoma	23
CCRL2 Expression by Specialized Lung Capillary Endothelial Cells Controls NK-cell Homing in Lung Cancer	22
TCR-Based Therapy Directed against Kallikrein-Related Peptidase 4 Is Safe and Effective against Prostate Cancer	22
Abstract PR-05: Sumoylation blockade exposes the dark epigenome to drive ZBP1 viral mimicry for cancer immunotherapy	22
ATF7ip inhibits the tumor immune response by promoting terminal CD8+ T cell Exhaustion	22
A Sampling of Highlights from the Literature	22
In Vivo Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade	22
Improvement of Tumor Neoantigen Detection by High-Field Asymmetric Waveform Ion Mobility Mass Spectrometry	22
Abstract C046: High-throughput phenotypic screening reveals novel immunomodulators that enhance immunotherapy in high-risk neuroblastoma	21
Autoantibodies Drive Heart Damage Caused by Concomitant Radiation and PD-1 Blockade	21
Coexisting Alterations of MHC Class I Antigen Presentation and IFNγ Signaling Mediate Acquired Resistance of Melanoma to Post–PD-1 Immunotherapy	21
Abstract A040: Measurement of CD8+ T cell-mediated anti-tumor immune response induced by neoadjuvant chemo-radiation therapy using T-cell receptor analysis in rectal cancer patient	21
Targeting LxCxE Cleft Pocket of Retinoblastoma Protein in Immunosuppressive Macrophages Inhibits Ovarian Cancer Progression	21
Neutralizing Antibodies Impair the Oncolytic Efficacy of Reovirus but Permit Effective Combination with T cell–Based Immunotherapies	20
Reprogramming CD8+ T-cell Branched N- Glycosylation Limits Exhaustion, Enhancing Cytotoxicity and Tumor Killing	20
CXCL10 Recruitment of γδ T Cells into the Hypoxic Bone Marrow Environment Leads to IL17 Expression and Multiple Myeloma Progression	20
IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8+ T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells	20
Battle Within the Sexes: Differences in Male and Female Immunity and the Impact on Antitumor Responses	19
Abstract LB-C004: Epigenetic immune reprogramming overcomes PD-1 resistance in metastatic melanoma patients: the phase II NIBIT-ML1 study	19
Abstract LB-A008: Reversing immune checkpoint inhibitor resistance rherapy in advanced thyroid cancer	19
Atypical B Cells Promote Cancer Progression and Poor Response to Bacillus Calmette-Guérin in Non–Muscle Invasive Bladder Cancer	18
Determinants for Antitumor and Protumor Effects of Programmed Cell Death	18
Translating Science into Survival: Report on the Seventh International Cancer Immunotherapy Conference	18
The E3 Ubiquitin Ligase FBXO38 Maintains the Antitumor Function of Natural Killer Cells by Sustaining IL15R Signaling	18
IL1R2 Deficiency Unleashes Neutrophil-Mediated Antitumor Potential in Sarcoma	18
A Sampling of Highlights from the Literature	18
Systematic Engineering of TROP2-Targeted CAR T-Cell Therapy Overcomes Resistance Pathways in Solid Tumors	18
Increased CaMKK2 Expression Is an Adaptive Response That Maintains the Fitness of Tumor-Infiltrating Natural Killer Cells	18
Intratumoral TREX1 Induction Promotes Immune Evasion by Limiting Type I IFN	18
Single-Cell Clonal Lineage Tracing Identifies the Transcriptional Program Controlling the Cell-Fate Decisions by Neoantigen-Specific CD8+ T Cells	17
Abstract B003: Oncolytic VSVd51-LIGHT and folfirinox chemotherapy increases anti-tumor immune response in pancreatic ductal adenocarcinoma	17
Constitutive STAT3 Signaling, in Comparison with STAT5, Enhances CAR T-cell Efficacy and Lowers Systemic Toxicity	17
CD8+ T Cells Keep Their (K+)urrency for Function	17
Adenosine-Deaminase-Acting-on-RNA-1 Facilitates T-cell Migration toward Human Melanoma Cells	17
Abstract B011: Mast cells mediate tumor-suppressive effects in head and neck cancer through immune-microenvironmental regulation	17
Inhibitor of Apoptosis Proteins Antagonist Induces T-cell Proliferation after Cross-Presentation by Dendritic Cells	17
A Metabolic Axis of Immune Intractability	17
CAR Binders Affect CAR T-cell Tonic Signaling, Durability, and Sensitivity to Target	17
MerTK Induces Dysfunctional Dendritic Cells by Metabolic Reprogramming	17
A Sampling of Highlights from the Literature: Article Recommendations from Our Deputy and Senior Editors	17
A Sampling of Highlights from the Literature	17
Abstract LB-A002: Open-label, Phase Ib dose-expansion study assessing the efficacy of the CD137/FAP agonist BI 765179 plus pembrolizumab as first-line therapy in metastatic or incurable, recurrent PD-	16
Abstract A043: Single-cell and bulk transcriptomics uncovers GATA3-mediated macrophage immunosuppressive programming in murine and human cancers	16
Pan-Cancer Single-Cell RNA Sequencing Analysis Refines Multi-Origin Monocyte and Macrophage Lineages	16
Abstract A011: IL-12 armored anti-macrophage CAR T cells reset and reprogram the tumor microenvironment to control metastatic ovarian and lung tumor growth	16
Abstract LB-B006: A Phase II chemo/immunotherapy study using metronomic gemcitabine, doxorubicin, docetaxel and nivolumab for advanced angiosarcoma (NCT04535713): An interim analysis	16
Combination CXCR4 and PD-1 Blockade Enhances Intratumoral Dendritic Cell Activation and Immune Responses Against Hepatocellular Carcinoma	16
Cancer Immunology Research: A Decade of Illumination and Innovation	16
Abstract B070: Fc-optimized GITR antibody enhances a CD4 T cell-dendritic cell crosstalk to promote anti-tumor immunity	16
Antitumor Immune Responses in B2M -Deficient Cancers	16
Regulatory Considerations for Genome-Edited T-cell Therapies	16
Tumor-derived complement C3 overexpression in STK11-mutant lung adenocarcinoma drives tumor growth and immune checkpoint inhibitor resistance	15
A Sampling of Highlights from the Literature: Article Recommendations from Our Deputy and Senior Editors	15
Abstract B022: Investigating Biased GPCRs Activation by Nutraceutical Caffeine and Nicotine in Transactivating Glycosylated Receptors to Induce EMT in Cancer Metastasis	15
A Sampling of Highlights from the Literature	15
A Sampling of Highlights from the Literature: Article Recommendations from Our Deputy and Senior Editors	15
The PO4-tential for Less Toxic CAR T-cell Therapies	15
Abstract IA03: Therapeutic modulation of nucleic acids-induced immune activation	15
Abstract C020: Spatial and molecular landscape in clear cell renal cell carcinoma bone metastatic patients	14
A “Function-First” Approach to Identify Regulatory T cell–Targeting Antibodies for Immunotherapy	14
Abstract B064: Association of different TP53 mutation subtypes with the efficacy of first-line immunotherapy in locally advanced and metastatic lung squamous cell carcinoma	14
Abstract C005: Understanding the Role of Tonic TCR Signaling to Optimize CAR-T Efficacy	14
Immunotherapy Inhibits Tumor Cholesterol Synthesis via the IFNγ–IRF1–SREBF2 Axis	14
Abstract A005: Utility of an oncogene-driven spontaneous triple-negative breast cancer model for immunotherapeutic testing	14
Abstract B002: A LIBRARY OF POTENT TCRS DERIVED FROM HEALTHY DONORS TARGETING KRAS G12D AND G12V NEOANTIGENS	14
Targeting SALL4 with an HLA Class I–Restricted TCR for Cancer Immunotherapy	14
Abstract A066: MMR-stratified spatial programs of normal and cancer-associated fibroblasts and their association with lymphocyte pervasiveness in CRC	14
The CCL17–CCR4 Axis Is Critical for Mutant STAT6-Mediated Microenvironmental Remodeling and Therapeutic Resistance in Relapsed/Refractory Diffuse Large B-Cell Lymphoma	14
Abstract A065: Fast and cost-effective prediction of treatment response in head and neck cancer by characterizing the tumor microenvironment from routine H&E slides	14
Abstract C057: Tankyrase Inhibition Reprograms Melanoma Metastases to Overcome Resistance to PD-1 Blockade	14

CD206+CD14− Skin-Resident Macrophages and DC–T Cell Clusters Are Spatial Features Characterizing Nonrelapsing Cutaneous Squamous Cell Carcinoma	14
M9657 Is a Bispecific Tumor-Targeted Anti-CD137 Agonist That Induces MSLN-Dependent Antitumor Immunity without Liver Inflammation	13
Nanobody-Directed CEA-Targeting CAR T Cells Eliminate Gastrointestinal Cancer Xenografts	13
TLR5 Signaling Causes Dendritic Cell Dysfunction and Orchestrates Failure of Immune Checkpoint Therapy against Ovarian Cancer	13
The Immunopeptidome from a Genomic Perspective: Establishing the Noncanonical Landscape of MHC Class I–Associated Peptides	13
HER2Δ16 Engages ENPP1 to Promote an Immune-Cold Microenvironment in Breast Cancer	13
Transient EZH2 Suppression by Tazemetostat during In Vitro Expansion Maintains T-Cell Stemness and Improves Adoptive T-Cell Therapy	13
Immunogenetic Metabolomics Reveals Key Enzymes That Modulate CAR T-cell Metabolism and Function	13
Identification of Core Techniques That Enhance Genome Editing of Human T Cells Expressing Synthetic Antigen Receptors	13
The Effects of Clinically Relevant Radionuclides on the Activation of an IFN1 Response Correlate with Radionuclide Half-life and Linear Energy Transfer and Influence Radiopharmaceutical Antitumor Effi	13
A Sampling of Highlights from the Literature	13
Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer	12
Abstract B007: Tissue-Specific B Cell Differentiation Limits Anti-Tumor Efficacy of Radiation and Immunotherapy	12
Abstract A051: Integrative Single-Cell and Spatial Transcriptomics Reveal Metabolic Reprogramming and Spatiotemporal Transition of Macrophages Driving Immune Suppression in Head and Neck Cancer	12
Upregulation of an Epithelial miRNA Is Associated with Immune Evasion in Progressive Bronchial Premalignant Lesions	12
Abstract B075: Innate lymphoid cell reprogramming reveals immunometabolic and epigenetic signatures following checkpoint blockade in head and neck squamous cell carcinoma (HNSCC)	12
Immune Modulation of Innate and Adaptive Responses Restores Immune Surveillance and Establishes Antitumor Immunologic Memory	12
Distinct Spatially Resolved Tumor Microenvironment Trajectories Define Benefit from Ramucirumab plus Pembrolizumab in Refractory PD-L1+ Gastric Cancer	12
Allogeneic CAR T Cells: Complex Cellular Therapy Designs Test the Limits of Our Preclinical Models	12
Abstract A049: CD8+ T cell decline from regression to recurrence in ovarian cancer is linked to expansion of suppressive macrophages	12
Abstract IA04: Reprogramming the tumor–immune microenvironment: From stromal circuits to engineered microbial immunotherapies	12
ATOR-4066, a Bispecific Antibody Targeting CD40 and CEACAM5, Induces Strong Myeloid and T Cell–Dependent Tumor Immunity and Synergizes with PD-1 Blockade	11
Abstract LB-C010: Flare: A clinical stage platform designed to overcome challenges of the tumor microenvironment and universally target tumors of epithelial origin	11
The Conventional Dendritic Cell 1 Subset Primes CD8+ T Cells and Traffics Tumor Antigen to Drive Antitumor Immunity in the Brain	11
Long-Read Sequencing Reveals Alternative Splicing-Driven, Shared Immunogenic Neoepitopes Regardless of SF3B1 Status in Uveal Melanoma	11
Cytometric Atlas of Combination Immunotherapy in Pancreatic Cancer: Blood-Based Signatures Reveal Vaccine and Checkpoint Inhibitor Responses	11
About the Rising Star	11
Dual Chimeric Antigen Receptor T Cells Targeting CD38 and SLAMF7 with Independent Signaling Demonstrate Preclinical Efficacy and Safety in Multiple Myeloma	11
PI3K/Akt Signaling Pathway Regulates CD155 Expression Involved in Resistance to Cancer Immunotherapy	11
Abstract LB-C006: Scalable TCR synthesis and screening enable antigen reactivity mapping	11
Low Serum Apolipoprotein A1 Levels Impair Antitumor Immunity of CD8+ T Cells via the HIF-1α–Glycolysis Pathway	11
Combination of Anti–PD-1 and Electroacupuncture Induces a Potent Antitumor Immune Response in Microsatellite-Stable Colorectal Cancer	11
Small Gene Networks Delineate Immune Cell States and Characterize Immunotherapy Response in Melanoma	11
CD49a Targeting Enhances NK Cell Function and Antitumor Immunity	11
Sequential Exposure to IL21 and IL15 During Human Natural Killer Cell Expansion Optimizes Yield and Function	11
Antigen Priming Induces Functional Reprogramming in iNKT Cells via Metabolic and Epigenetic Regulation: An Insight into iNKT Cell-Based Antitumor Immunotherapy	11
CD73 Inhibits cGAS–STING and Cooperates with CD39 to Promote Pancreatic Cancer	11
CD4+ Regulatory T Cells in Human Cancer: Subsets, Origin, and Molecular Regulation	11
Impact of scFv on Functionality and Safety of Third-Generation CD123 CAR T Cells	11
TIME for Endometrial Cancer: Advancements and Challenges in Therapeutic Targets for the Endometrial Cancer Tumor Immune Microenvironment	11
Systemic Alterations in Type-2 Conventional Dendritic Cells Lead to Impaired Tumor Immunity in Pancreatic Cancer	10
Abstract A005: TAZ-TEAD signaling alters the immune microenvironment of cutaneous melanoma	10
Abstract B025: Anti-GD2 combined with anti-PD1 enhances tumor immunity with T cell memory via inducing immunogenic cell death	10
Abstract IA04: Investigating T cell immunobiology using genetically engineered models	10
Unlocking the Immune Response in ALK-Rearranged Lung Adenocarcinoma	10
Abstract A015: The emerging role of basophils in non-muscle-invasive bladder cancer	10
Abstract C023: Tertiary lymphoid structures generate anti-tumor immunity independently of immune responses in secondary lymphoid organs upon STING and lymphotoxin-β receptor activation	10
Let the Guard Down: cAMP Activators Can Improve Immunotherapy in GBM	10
A Sampling of Highlights from the Literature: Article Recommendations from Our Deputy and Senior Editors	10
Efficacy and Synergy with Cisplatin of an Adenovirus Vectored Therapeutic E1E2E6E7 Vaccine against HPV Genome–Positive C3 Cancers in Mice	10
Abstract A004: A minimal gene panel approach for cost-effective identification of tumor-reactive T cells	10
The TRIB2–DNMT1 Pathway Generates an Immune-Cold Microenvironment in Glioblastoma, and Its Inhibition Promotes Immunotherapy	9
TBK1 Targeting Is Identified as a Therapeutic Strategy to Enhance CAR T-Cell Efficacy Using Patient-Derived Organotypic Tumor Spheroids	9
A Sampling of Highlights from the Literature	9
The Problem with Syngeneic Mouse Tumor Models	9
Abstract PR-15: Neuroimmune dysregulation in ovarian cancer: the role of chronic stress on microglial activation and systemic inflammation	9
Abstract C008: NFIL3 emerges as a driver of CAR T cell dysfunction from integrated in vivo/in vitro CRISPR screen	9
Abstract A017: Neutrophil extracellular traps reprogram macrophages to an immunosuppressive phenotype in non-small-cell lung cancer	9
Tertiary Lymphoid Structures Are Associated with Enhanced Macrophage Activation and Immune Checkpoint Expression and Predict Outcome in Cervical Cancer	9
Chronic ISG15 Exposure Accelerates CD8+ T-cell Dysfunction while Increasing PD-1 Blockade Sensitivity in Oral Squamous Cell Carcinoma	9
A Sampling of Highlights from the Literature	9
Abstract IA08: Development and use of Engineered Regulatory T cells to treat Autoimmune Diseases	9
Abstract C044: Analysis of 1000 secreted proteins in functional genomics and compound screens reveals cytotoxic and immunomodulatory targets	9
Abstract B036: Systemic and tumor-microenvironment inflammation shape outcomes in patients with immunologically cold, treatment-refractory tumors treated with Fc-enhanced anti–CTLA-4 botensilimab	9
Abstract A023: Myeloid checkpoint blockade potentiates radiotherapy by modulating dendritic cells and reducing Treg-driven immunosuppression	9
The Dark Knight: Functional Reprogramming of Neutrophils in the Pathogenesis of Colitis-Associated Cancer	9
Abstract C051: Genomic and spatial immune biomarkers predictive of chemoimmunotherapy response in triple-negative breast cancer	9
Abstract A006: Assessment of EBV DNA methylation to guide antiviral use in EBV-associated lymphoma	9
Abstract B027: iSIGN panel identifies germ cell tumors via whole-proteome phage immunoprecipitation sequencing	9
Abstract A072: The T cell precursor frequency determines the immunogenicity of cancer neoantigens	9
iBRIDGE: A Data Integration Method to Identify Inflamed Tumors from Single-cell RNA-Seq Data and Differentiate Cell Type–Specific Markers of Immune-Cell Infiltration	9
Abstract B021: Multi-functional telodendrimer nanodrug: Nanocarrier for ovarian cancer treatment and immunomodulator to control inflammation and sensitize the tumor	8
Abstract B055: Optimizing longitudinal peripheral blood–based immune monitoring in cancer patients by single-cell mass cytometry	8
Abstract B033: Leveraging PSGL-1 blockade to elicit responses to anti-PD-1 immunotherapy resistant melanoma	8
A Sampling of Highlights from the Literature: Article Recommendations from Our Deputy and Senior Editors	8
Interactions between MDSCs and the Autonomic Nervous System: Opportunities and Challenges in Cancer Neuroscience	8
Host Tissue Factors Predict Immune Surveillance and Therapeutic Outcomes in Gastric Cancer	8
Abstract A003: Identification of immunomodulatory compounds by high-throughput proteomics: Insights from quantification of 1000 proteins in a 20,000 sample screen	8
Abstract A004: Modulating chromatin remodeling as a strategy to reverse immune evasion in ovarian cancer	8
Abstract A067: A patient-derived 3D MicroOrganoSpheres® (MOS®) platform to evaluate functional potency of autologous TILs in Non-Small Cell Lung Cancer (NSCLC)	8
Abstract C036: Radiotherapy increases circulating early-stage natural killer cells with enhanced cytokine responsiveness in breast cancer	8
Targeted Lipid Nanoparticle Delivery of FAP-CAR mRNA Enables Potent In Vivo T-cell Engineering against Pancreatic Tumors	8
Tyrosine Kinase Inhibition Activates Intratumoral γδ T Cells in Gastrointestinal Stromal Tumor	8
A Sampling of Highlights from the Literature: Article Recommendations from Our Deputy and Senior Editors	8
Mesenchymal Stem Cells and Fibroblasts Contribute to Microvascular Proliferation in Glioblastoma and are Correlated with Immunosuppression and Poor Outcome	8
Abstract B004: Route dependent T-cell activation by mRNA cluster therapies	8
Abstract PR-12: Single-cell profiling of tumor-infiltrating B cells reveals autoantibody repertoires and potential cross-talk with T cells	8
Abstract C029: Uncovering interferon gamma signaling programs that drive resistance to cancer immunotherapy	8
Regulatory Programs of B-cell Activation and Germinal Center Reaction Allow B-ALL Escape from CD19 CAR T-cell Therapy	8
High-Dimensional Analyses Reveal IL15 Enhances Activation of Sipuleucel-T Lymphocyte Subsets and Reverses Immunoresistance	8
Abstract LB-B012: Signals from the tumor immune microenvironment induce a potent immune modulatory gene expression program in senescent breast tumor cells	8
Gastric Microbiome Alterations Are Associated with Decreased CD8+ Tissue-Resident Memory T Cells in the Tumor Microenvironment of Gastric Cancer	8