OOIR: Observatory of International Research

Papers

(The TQCC of Biomedical Journal is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Polycystic kidney disease increases the stoke incidence in Taiwan: A retrospective population-based cohort study using National Health Insurance Database	158
Aptamer-functionalized liposomes for drug delivery	89
Cell polarity regulators, multifunctional organizers of lymphocyte activation and function	86
Roles of lncRNAs in the transcription regulation of HIV-1	54
One day at a time	46
Living with tics: Nursing care of pediatric Tourette syndrome	45
Autonomic modulation and the risk of dementia in a middle-aged cohort: A 17-year follow-up study	45
Hyperammonemia induces microglial NLRP3 inflammasome activation via mitochondrial oxidative stress in hepatic encephalopathy	44
HIF-1 AND DEC-1 LEVELS IN ACUTE ISCHAEMIC STROKE PATIENTS: COULD DEC-1 BE A NEW BIOMARKER IN STROKE?	43
Fu's Subcutaneous Needling Therapy Significantly Enhances Pain Relief in Sciatica Rats by Promoting Mitochondrial Autophagy	43
Editorial Board	38
Antrodia cinnamomea extract alleviates bleomycin-induced pulmonary fibrosis in mice by inhibiting the mTOR pathway	38
Editorial Board	36
Editorial Board	36
Middle cerebral artery velocity is associated with the severity of MRI brain injury in neonates received therapeutic hypothermia	35
m6A landscape is more pervasive when Trypanosoma brucei exits the cell cycle	31
Clinical and genomic insights into persistent carbapenem-resistant Klebsiella pneumoniae bacteremia: risk factors, resistance mechanisms, and treatment challenges	31
High-throughput proteomics-guided biomarker discovery of hepatocellular carcinoma	30
The establishment of a molecular diagnostic platform for mitochondrial diseases: From conventional to next-generation sequencing	29
Bilateral lentiform and caudate nucleus lesions in a child with COVID-19: A case report	29
When it doesn't run in the blood(vessels) – events involved in vascular disorders	28
Implementation of fecal microbiota transplantation in a medical center for recurrent or refractory Clostridioides difficile infection and report of preliminary outcome	27
Macrophages in the male genital tract	27
Saliva as a diagnostic tool to measure polycyclic aromatic hydrocarbon exposure in dental patients exposed to intimate partner violence (IPV)	27
Comprehensive insight into the alterations in the gut microbiome and the intestinal barrier as a consequence of iron deficiency anaemia	26

The effects of macronutrients metabolism on cellular and organismal aging	25
Tools to measure membrane potential of neurons	24
Influence of acupuncture twisting parameters on analgesic effects mediated by mast cells in AA rat models	24
Lifestyle interventions to delay senescence	24
The binding and specificity of chemokine binding proteins, through the lens of experiment and computation	23
Long non-coding RNA HAGLROS facilitates the malignant phenotypes of NSCLC cells via repressing miR-100 and up-regulating SMARCA5	23
Glycolytic metabolism and activation of Na+ pumping contribute to extracellular acidification in the central clock of the suprachiasmatic nucleus: Differential glucose sensitivity and utilization betw	23
Discrepant Treponemal Test Results: Identification of Associated Risk Factors Through Machine Learning Technology in 18-Year Electronic Medical Records and National Claims Data	22
Additional insights on SARS-CoV-2 spike protein variants and red blood cells biology	22
Using time-course as an essential factor to accurately predict sepsis-associated mortality among patients with suspected sepsis	22
Circadian rhythmicity and human health	21
Caffeic acid phenethyl ester inhibits the growth of bladder carcinoma cells by upregulating growth differentiation factor 15	21
“Mpox in MSM: Tackling stigma, minimizing risk factors, exploring pathogenesis, and treatment approaches”	20
Dynamic Regulation of RNA m6A Methylation in the Ribonucleoprotein Complexes in Apicomplexan and Kinetoplastid Parasites	20
Repeated administration of adipose-derived mesenchymal stem cells added on beneficial effects of empagliflozin on protecting renal function in diabetic kidney disease rat	20
Inhibition of NLRP3 attenuates sodium dextran sulfate-induced inflammatory bowel disease through gut microbiota regulation	20
A panel of miRNAs in the serum extracellular vesicles serve as novel diagnostic biomarkers for MASLD	20
Automatic and human level Graf's type identification for detecting developmental dysplasia of the hip	20
Purinergic signaling: A new front-line determinant of resistance and susceptibility in leishmaniasis	20
Sterile inflammation and the NLRP3 inflammasome in cardiometabolic disease	19
Effect of three clinical therapies on cytokines modulation in the hip articular cartilage and bone improvement in rat early osteonecrosis of the femoral head	19
Advancements, challenges, and future prospects in clinical hyperpolarized magnetic resonance imaging: A comprehensive review	19
Discharge status validation of the Chang Gung Research database in Taiwan	19
Editorial Board	19
Fecal miRNAs as potential biomarkers for early detection of colorectal cancer: An updated review	19
Angular super-resolution in X-ray projection radiography using deep neural network: Implementation on rotational angiography	18
Multifunctional nanozymes for disease diagnosis and therapy	18
Nod-like receptors in inflammatory arthritis	18
A finger in every pie – The versatility of chemokines	18
Low energy shock wave therapy attenuates mitochondrial dysfunction and improves bladder function in HCl induced cystitis in rats	18
Structural, biochemical, and functional properties of the Rap1-Interacting Adaptor Molecule (RIAM)	18
Comparing transvenous coiling and transarterial embolization with Onyx/NBCA for cavernous sinus dural arteriovenous fistulas: A retrospective study in a single center	18
Circ_0011385 knockdown inhibits cell proliferation, migration and invasion, whereas promotes cell apoptosis by regulating miR-330-3p/MYO6 axis in colorectal cancer	18
Systematic analysis of mushroom body-innervating dopaminergic neuron activity in different physiological states in Drosophila	18
Hyperthermic intraperitoneal chemotherapy for recurrent epithelial ovarian cancer	17
Ancient wisdom and modern innovations: Methods of administering healing	17
Acquired Immune Deficiency Syndrome correlation with SARS-CoV-2 N genotypes	17
The incidence of resistance-associated variants to NS5A in HCV subtypes 1a and 1b in Taiwan	17
Current efforts and challenges facing responses to Monkeypox in United Kingdom	17
Extracellular vesicles in fetal-maternal immune tolerance	17
Endothelial activation, cell-cell interactions, and inflammatory pathways in postoperative atrial fibrillation following cardiac surgery	17
Response to "letter to editor" from Nicolini et al. Regarding "Autonomic modulation and the risk of dementia in a middle-aged cohort: A 17-year follow-up study"	17
Circ_0091579 exerts an oncogenic role in hepatocellular carcinoma via mediating miR-136-5p/TRIM27	16
Long Non-Coding RNAs as Modulators of Metabolic Reprogramming for Endogenous Heart Regeneration: Mechanisms and Therapeutic Potential	16
In vitro axotomy models regulated by ROCK inhibitor for studying neuroregeneration and growth cone morphology	16
SARS-CoV-2 variants – Evolution, spike protein, and vaccines	16
Clinical validation of a saliva-based matrix metalloproteinase-1 rapid strip test for detection of oral cavity cancer	16
Advancing cancer diagnosis and treatment: Integrating molecular biomarkers and emerging technologies	16
Pharmacological therapy for Tourette syndrome: What medicine can do and cannot do	15
Surgery for metastatic epidural spinal cord compression in thoracic spine, anterior or posterior approach?	15

CAN008 prolongs overall survival in patients with newly diagnosed GBM characterized by high tumor mutational burden	15
Inhibition of the 4-hydroxynonenal-regulated JNK/c-Jun pathway improves bleomycin-induced lung fibrosis	15
Strides toward a better understanding of the “Current efforts and challenges facing responses to Monkeypox in United Kingdom”	15
Significant decrease of a master regulator of genes (REST/NRSF) in high-grade squamous intraepithelial lesion and cervical cancer	15
Joint effects of genomic markers and urinary methylation capacity associated with inorganic arsenic metabolism on the occurrence of cancers among residents in arseniasis-endemic areas: A cohort subset	15
Clinical and functional characteristics of lung surgery-related vocal fold palsy	14
The epidemiology of invasive fungal infections in transplant recipients	14
Mitochondrial dysfunction route as a possible biomarker and therapy target for human cancer	14
Altered diffusivity of the subarachnoid cisterns in the rat brain following neurological disorders	14
Chronic low-dose REV-ERBs agonist SR9009 mitigates constant light-induced weight gain and insulin resistance via adipogenesis modulation	14
Inherently imperfect, inherently evolving – The pursuit of precision through biomarkers	14
Author reply to letter to the editor “Imaging abnormalities in pediatric neuro-COVID are more diverse than specified”	14
Autophagy-induced osteoblast-derived exosomes maintain bone formation and prevent osteoporosis by remodeling gut microbiota-metabolism	13
Clinical significance of incidental common bile duct dilatation in children: A 10-year single medical center experience	13
Mouth opening/breathing is common in sleep apnea and linked to more nocturnal water loss	13
Targeted dexamethasone nano-prodrug for corneal neovascularization management	13
Editorial Board	13
Utilizing nomograms to predict prevalent vertebral fracture risk: An analysis of dysmobility syndrome in a community-dwelling population	13
The best protection is early detection	13
Macrophages of the Heart: Homeostasis and Disease	13
Phosphorylated α-synuclein in diluted human serum as a biomarker for Parkinson's disease	13
Glomerular disease classification and lesion identification by machine learning	12
Biological functions of extracellular vesicles from mammalian cells	12
A comprehensive overview of gastric cancer management from a surgical point of view	12
Factors associated with pyloric hypertrophy severity and post-operative feeding and nutritional recovery in infantile hypertrophic pyloric stenosis	12
Blood oxygenation state in COVID-19 patients: Unexplored role of 2,3-bisphosphoglycerate	12
A CD33 frameshift variant is associated with neuromyelitis optica spectrum disorders	12
Comparison of the outcome of emergency endotracheal intubation in the general ward, intensive care unit and emergency department	12
Editorial Board	12
Curcumin suppresses RANKL-induced osteoclast precursor autophagy in osteoclastogenesis by inhibiting RANK signaling and downstream JNK-BCL2-Beclin1 pathway	11
Practical applications of grounding to support health	11
ShinySC: an R/Shiny-based desktop application for seamless analysis of scRNA-Seq data	11
Prognosis of chronic kidney disease in patients with non-alcoholic fatty liver disease: a Northeastern Taiwan community medicine research cohort	11
Editorial Board	11
Plasminogen Activator Inhibitor-1 in Systemic Sclerosis: A Nexus of Fibrosis, Vasculopathy, and Senescence	11
Genomic surveillance of SARS-CoV-2 in Taiwan: A perspective on evolutionary data interpretation and sequencing issues	11
Phylogenetic characteristics of Non-SARS human coronavirus in southern Taiwan, 2012–2013	11
Complementary effects of Orthosiphon stamineus standardized ethanolic extract and rosmarinic acid in combination with gemcitabine on pancreatic cancer	11
LncRNAs and asymmetric cell division: The epigenetic mechanisms	10
Infection control operations of a large hospital in Taiwan to prevent nosocomial outbreaks during COVID-19 pandemic	10
Antibody induction in mice by liposome-displayed recombinant enterotoxigenic Escherichia coli (ETEC) colonization antigens	10
Negative regulatory NLRs mitigate inflammation via NF-κB pathway signaling in inflammatory bowel disease	10
COVID-19 vaccination uptake strongly predicts averted deaths of older people across Europe	10
The 2022 nobel prize in physiology or medicine awarded for the decoding of the complete ancient human genome	10
BrainView: A Cloud-based Deep Learning System for Brain Image Segmentation, Tumor Detection and Visualization	10
Immunosenescence, gut dysbiosis, and chronic kidney disease: Interplay and implications for clinical management	10
The clockwork macrophage: timing in innate immunity	10
Editorial Board	10
Editorial Board	10