Biomedical Journal

Article	Citations
COVID-19: The first documented coronavirus pandemic in history	479
Artificial intelligence approach fighting COVID-19 with repurposing drugs	156
Comprehensive review of coronavirus disease 2019 (COVID-19)	97
DNA copy number variation: Main characteristics, evolutionary significance, and pathological aspects	87
Innate immunity drives pathogenesis of rheumatoid arthritis	86
Understanding the role of neutrophils in acute respiratory distress syndrome	83
Brain-derived neurotrophic factor and mental disorders	77
Fighting COVID-19: A quick review of diagnoses, therapies, and vaccines	70
Machine learning techniques for sequence-based prediction of viral–host interactions between SARS-CoV-2 and human proteins	69
Endothelial glycocalyx damage as a systemic inflammatory microvascular endotheliopathy in COVID-19	61
Is there an association between oral health and severity of COVID-19 complications?	61
Human adenovirus infections in pediatric population - An update on clinico–pathologic correlation	60
The role of miRNA biogenesis and DDX17 in tumorigenesis and cancer stemness	52
Repurposing old drugs as antiviral agents for coronaviruses	49
G6PD: A hub for metabolic reprogramming and redox signaling in cancer	41
Pediatric abusive head trauma	40
Lopinavir/ritonavir: Repurposing an old drug for HIV infection in COVID-19 treatment	38
Development of multi-epitope peptide-based vaccines against SARS-CoV-2	36
Neutralizing monoclonal antibodies for COVID-19 treatment and prevention	35
Perilla (Perilla frutescens) leaf extract inhibits SARS-CoV-2 via direct virus inactivation	35
SARS-CoV-2, the other face to SARS-CoV and MERS-CoV: Future predictions	33
Computation screening of narcissoside a glycosyloxyflavone for potential novel coronavirus 2019 (COVID-19) inhibitor	33
Exploring algae and cyanobacteria as a promising natural source of antiviral drug against SARS-CoV-2	28
Exposure to PM2.5 and PM10 and COVID-19 infection rates and mortality: A one-year observational study in Poland	28
LncRNA MALAT1 promotes breast cancer progression and doxorubicin resistance via regulating miR-570–3p	28

RASopathies: From germline mutations to somatic and multigenic diseases	27
SARS-CoV-2 variants – Evolution, spike protein, and vaccines	26
Germline STAT3 gain-of-function mutations in primary immunodeficiency: Impact on the cellular and clinical phenotype	25
3D culture models to study SARS-CoV-2 infectivity and antiviral candidates: From spheroids to bioprinting	25
Effects of electronic cigarette aerosol exposure on oral and systemic health	24
Artificial neural network and logistic regression modelling to characterize COVID-19 infected patients in local areas of Iran	24
Phytochemicals against SARS-CoV as potential drug leads	24
Podoplanin promotes cancer-associated thrombosis and contributes to the unfavorable overall survival in an ectopic xenograft mouse model of oral cancer	23
Primary ovarian insufficiency, meiosis and DNA repair	23
The role of GPR56/ADGRG1 in health and disease	23
Role of bacterial infections in extracellular vesicles release and impact on immune response	23
Lymphoid Tissue inducer (LTi) cell ontogeny and functioning in embryo and adult	23
Assessing the application of a pseudovirus system for emerging SARS-CoV-2 and re-emerging avian influenza virus H5 subtypes in vaccine development	23
Current updates on the European and WHO registered clinical trials of coronavirus disease 2019 (COVID-19)	22
Immune checkpoint deficiencies and autoimmune lymphoproliferative syndromes	22
Banking on teeth – Stem cells and the dental office	21
Sex hormone regulation of innate lymphoid cells	21
Valinomycin as a potential antiviral agent against coronaviruses: A review	21
Balancing the dental occlusion and facial aesthetic features in cleft orthognathic surgery: Patient-centered concept for computer-aided planning	20
Interventions of aqueous extract of Solanum melongena fruits (garden eggs) on mercury chloride induced testicular toxicity in adult male Wistar rats	20
Effects of physical exercise on children with attention deficit hyperactivity disorder	19
Glomerular disease classification and lesion identification by machine learning	19
Point-of-care ultrasound of optic nerve sheath diameter to detect intracranial pressure in neurocritically ill children - A narrative review	19
Intravascular Large B-cell lymphoma: A case series and review of literatures	18
Immunotherapy in older patients with cancer	18
Modified ELISA for antibody avidity evaluation: The need for standardization	18
Role of SARS-CoV-2 and ACE2 variations in COVID-19	18
Application of ketogenic diets for pediatric neurocritical care	16
Targeting mitochondrial bioenergetics as a promising therapeutic strategy in metabolic and neurodegenerative diseases	16
The respiratory impacts of air pollution in children: Global and domestic (Taiwan) situation	16
The Notch signaling pathway involvement in innate lymphoid cell biology	16
A recipe for a good clinical pulmonary surfactant	16
The genetic landscape of the FAS pathway deficiencies	15
The role of hypoxia-induced long noncoding RNAs (lncRNAs) in tumorigenesis and metastasis	15
Neurocritical care for Anti-NMDA receptor encephalitis	15
Pediatric care for children with developmental coordination disorder, can we do better?	15
Type 1 innate lymphoid cells: Soldiers at the front line of immunity	15
The role and mechanism of CARD9 gene polymorphism in diseases	15
Brain stimulation treatments in epilepsy: Basic mechanisms and clinical advances	14
Development and validation of a deep-learning-based pediatric early warning system: A single-center study	14
Neurocritical care of premature infants	14
Surgical treatment of femoral head fractures	13
Metabolomics as a promising tool for improving understanding of multiple sclerosis: A review of recent advances	13
A novel CAD/CAM composite occlusal splint for intraoperative verification in single-splint two-jaw orthognathic surgery	13
A brief review on potential application of mesenchymal stem cell and secretome in combating mortality and morbidity in COVID-19 patients	13
Suppression of MGAT3 expression and the epithelial–mesenchymal transition of lung cancer cells by miR-188-5p	13
Diminished toll-like receptor response in febrile infection-related epilepsy syndrome (FIRES)	13
Typical and atypical enteropathogenic Escherichia coli in children with acute diarrhoea: Changing trend in East Delhi	13
Discovery of serum biomarkers for diagnosis of tuberculosis by NMR metabolomics including cross-validation with a second cohort	13
Rapid responses in the emergency department of Linkou Chang Gung Memorial Hospital, Taiwan effectively prevent spread of COVID-19 among healthcare workers of emergency department during outbreak: Less	13

Multimodal neurocritical monitoring	13
Circ_0091579 exerts an oncogenic role in hepatocellular carcinoma via mediating miR-136-5p/TRIM27	12
Rapid establishment of a COVID-19 biobank in NHRI by National Biobank Consortium of Taiwan	12
Cellular senescence and the host immune system in aging and age-related disorders	12
Roles of lncRNAs in the transcription regulation of HIV-1	12
A multicompartment vascular implant of electrospun wintergreen oil/ polycaprolactone fibers coated with poly(ethylene oxide)	12
Clinical characteristics and treatment outcome of adenoid cystic carcinoma in the external auditory canal	12
MicroRNA-95-3p inhibits cell proliferation and metastasis in colorectal carcinoma by HDGF	12
Bone marrow-derived mesenchymal stem cells transplantation ameliorates renal injury through anti-fibrotic and anti-inflammatory effects in chronic experimental renovascular disease	12
Impact of prepregnancy body mass index on pregnancy outcomes, incidence of urinary incontinence and quality of life during pregnancy - An observational cohort study	12
Breath volatile organic compounds (VOCs) as biomarkers for the diagnosis of pathological conditions: A review	12
Updates on the ketogenic diet therapy for pediatric epilepsy	12
Cell polarity regulators, multifunctional organizers of lymphocyte activation and function	12
Postnatal intestinal mucosa and gut microbial composition develop hand in hand: A mouse study	11
Current and future applications of fecal microbiota transplantation for children	11
Time course and epidemiological features of COVID-19 resurgence due to cold-chain food or packaging contamination	11
Bladder volume reproducibility after water consumption in patients with prostate cancer undergoing radiotherapy: A systematic review and meta-analysis	11
Concomitant infection with COVID-19 and Mycoplasma pneumoniae	11
Neurocritical care and target immunotherapy for febrile infection-related epilepsy syndrome	11
Low energy shock wave therapy attenuates mitochondrial dysfunction and improves bladder function in HCl induced cystitis in rats	11
Discharge status validation of the Chang Gung Research database in Taiwan	11
Surgical management of intraventricular hemorrhage and posthemorrhagic hydrocephalus in premature infants	11
Functional roles of non-coding RNAs regulated by thyroid hormones in liver cancer	11
Comparison of the Roche cobas 6800 SARS-CoV-2 test and the Taiwan CDC protocol for the molecular diagnosis of COVID-19	10
Therapeutic effect of bone marrow mesenchymal stem cells in a rat model of carbon tetrachloride induced liver fibrosis	10
3-Hydroxybenzaldehyde and 4-Hydroxybenzaldehyde enhance survival of mouse astrocytes treated with Angiostrongylus cantonensis young adults excretory/secretory products	10
Complementary effects of Orthosiphon stamineus standardized ethanolic extract and rosmarinic acid in combination with gemcitabine on pancreatic cancer	10
Tourette disorder and sleep	10
COVID-19 and gastrointestinal system: A brief review	10
Modification of brain waves and sleep parameters by Citrus reticulata Blanco. cv. Sai-Nam-Phueng essential oil	10
Modified natriuretic peptides and their potential roles in cancer treatment	10
Immunoinformatics prediction of potential B-cell and T-cell epitopes as effective vaccine candidates for eliciting immunogenic responses against Epstein–Barr virus	10
Spectrum of neuroimaging mimics in children with COVID-19 infection	9
Current efforts and challenges facing responses to Monkeypox in United Kingdom	9
5-day multi-session intermittent theta burst stimulation over bilateral posterior superior temporal sulci in adults with autism-a pilot study	9
Integrative immunoinformatics paradigm for predicting potential B-cell and T-cell epitopes as viable candidates for subunit vaccine design against COVID-19 virulence	9
Endoscopic transcanal removal of external auditory canal osteomas	9
Seizures severity during rewarming can predict seizure outcomes of infants with neonatal hypoxic-ischemic encephalopathy following therapeutic hypothermia	9
Cardiac troponin elevation in patients with influenza virus infections	9
Regenerative medicine for male infertility: A focus on stem cell niche injury models	9
Long non-coding RNA LINC01559 serves as a competing endogenous RNA accelerating triple-negative breast cancer progression	9
Influence of electromagnetic fields on the circadian rhythm: Implications for human health and disease	9
MicroRNAs (−146a, −21 and −34a) are diagnostic and prognostic biomarkers for diabetic retinopathy	9
Cell therapy in vascularized composite allotransplantation	9
The role of endocytic trafficking in antigen T cell receptor activation	9
Strategies to protect surfactant and enhance its activity	9
Caffeic acid phenethyl ester inhibits the growth of bladder carcinoma cells by upregulating growth differentiation factor 15	9
Circulating tumor cell enumeration for improved screening and disease detection of patients with colorectal cancer	8
Current understanding of the genetics of Tourette syndrome	8
Race with virus evolution: The development and application of mRNA vaccines against SARS-CoV-2	8
Personalized medicine: From diagnostic to adaptive	8
Evaluation of recurrence risk in patients with papillary thyroid cancer through tumor-node-metastasis staging: A single-center observational study in Taiwan	8
Tools to measure membrane potential of neurons	8
Phosphorylated α-synuclein in diluted human serum as a biomarker for Parkinson's disease	8
Pristimerin exerts antitumor activity against MDA-MB-231 triple-negative breast cancer cells by reversing of epithelial-mesenchymal transition via downregulation of integrin β3	8
Antisiphon device: A review of existing mechanisms and clinical applications to prevent overdrainage in shunted hydrocephalic patients	8
Infection control operations of a large hospital in Taiwan to prevent nosocomial outbreaks during COVID-19 pandemic	8
Comparison of the outcome of emergency endotracheal intubation in the general ward, intensive care unit and emergency department	8
High levels estradiol affect blastocyst implantation and post-implantation development directly in mice	8
Undergraduates’ preparedness for practice is associated with professional identity and perception of educational environment: A validation study	8
Comparison of the effects between lasers applied to myofascial trigger points and to classical acupoints for patients with cervical myofascial pain syndrome	7
Population based norms for the box and blocks test in healthy right-handed Taiwanese adults	7
The NLR member CIITA: Master controller of adaptive and intrinsic immunity and unexpected tool in cancer immunotherapy	7
Clinical features, laboratory findings and persistence of virus in 10 children with coronavirus disease 2019 (COVID-19)	7
Applications of three-dimensional imaging techniques in craniomaxillofacial surgery: A literature review	7
Short-term and long-term psychological impact and quality of life of patients undergoing orthognathic surgery	7
LncRNA OIP5-AS1 reduces renal epithelial cell apoptosis in cisplatin-induced AKI by regulating the miR-144-5p/PKM2 axis	7
Different impacts of common risk factors associated with thrombocytopenia in patients with hepatitis B virus and hepatitis C virus infection	7
Performance of two frailty screening tools among patients with cancer in Taiwan	7
Progesterone eliminates 17β-estradiol-Mediated cardioprotection against diabetic cardiovascular dysfunction in ovariectomized rats	7
Outcome and cost analysis of primary total knee arthroplasty in end-stage renal disease patients: A nationwide population-based study	6
Application of Solidago chilensis and laser improved the repair of burns in diabetic rats	6
Negative regulatory NLRs mitigate inflammation via NF-κB pathway signaling in inflammatory bowel disease	6
Management of intracranial vertebral artery stenosis with ipsilateral vertebral artery hypoplasia and contralateral vertebral artery occlusion via type 2 proatlantal intersegmental artery	6
Discoveries of how cells sense oxygen win the 2019 Nobel Prize in Physiology or medicine	6
Dynamic monitoring of kidney injury status over 3 days in the intensive care unit as a sepsis phenotype associated with hospital mortality and hyperinflammation	6
A review for cell and particle tracking on microscopy images using algorithms and deep learning technologies	6
Emerging mutation in SARS-CoV-2 spike: Widening distribution over time in different geographic areas	6
MicroRNA-based signature for diagnosis and prognosis of colorectal cancer using residuum of fecal immunochemical test	6
Implementation of fecal microbiota transplantation in a medical center for recurrent or refractory Clostridioides difficile infection and report of preliminary outcome	6

Lipopeptides against COVID-19 RNA-dependent RNA polymerase using molecular docking	6
Hyperthermic intraperitoneal chemotherapy for recurrent epithelial ovarian cancer	6
Circ_0011385 knockdown inhibits cell proliferation, migration and invasion, whereas promotes cell apoptosis by regulating miR-330-3p/MYO6 axis in colorectal cancer	6
Scaling the tips of the ALPS	6
Stereotactic body radiotherapy plus cetuximab for previously irradiated un-resectable head and neck cancer	6
Effect of oral nitrite administration on gene expression of SNARE proteins involved in insulin secretion from pancreatic islets of male type 2 diabetic rats	6
Techniques to evaluate surfactant activity for a personalized therapy of RDS neonates	6
Pandemic number five – Latest insights into the COVID-19 crisis	5
Neurotrophins BDNF and NT4/5 accelerate dental pulp stem cell migration	5
Sterile inflammation and the NLRP3 inflammasome in cardiometabolic disease	5
Long non-coding RNA HAGLROS facilitates the malignant phenotypes of NSCLC cells via repressing miR-100 and up-regulating SMARCA5	5
The combination of low level laser therapy and efavirenz drastically reduces HIV infection in TZM-bl cells	5
Recovery of walking ability in stroke patients through postacute care rehabilitation	5
Comparison of physical electrical conductivity and acupuncture de-qi sensation between stainless steel needling and supercritical fluid-treated needling	5
Stress while lacking of control induces ventral hippocampal autophagic flux hyperactivity and a depression-like behavior	5
Joint effects of genomic markers and urinary methylation capacity associated with inorganic arsenic metabolism on the occurrence of cancers among residents in arseniasis-endemic areas: A cohort subset	5
High fructose induced osteogenic differentiation of human valve interstitial cells via activating PI3K/AKT/mitochondria signaling	5
Association of preoperative frailty and postoperative delirium in older cancer patients undergoing elective abdominal surgery: A prospective observational study in Taiwan	5
The effects of bone-substitute augmentation on treatment of osteoporotic intertrochanteric fractures	5
Clinical application of target temperature management in children with acute encephalopathy–A practical review	5
Diffusion tensor imaging for the differential diagnosis of Parkinsonism by machine learning	5
In-vitro and in-vivo functional observation studies to establish therapeutic potential of alpha-ketoglutarate against methotrexate induced liver injury	5
Eligibility for live, interactive otolaryngology telemedicine: 19-Month experience before and during the COVID-19 pandemic in Taiwan	5
Association between serum bilirubin levels and progression of albuminuria in Taiwanese with type 2 diabetes mellitus	5
One-year stability of the mandibular advancement and counterclockwise rotation for correction of the skeletal class II malocclusion and high mandibular plane angle: Dental and skeletal aspect	5
Apremilast ameliorates acute respiratory distress syndrome by inhibiting neutrophil-induced oxidative stress	5
Phospholipases A2 as biomarkers in acute respiratory distress syndrome	5
Investigation of echocardiographic characteristics and predictors for persistent defects of patent foramen ovale or patent ductus arteriosus in Chinese newborns	5
Prevention and treatment of COVID-19 infection by earthing	5
Inherited immunodeficiencies associated with proximal and distal defects in T cell receptor signaling and co-signaling	5
Differential inflammatory response of men and women subjected to an acute resistance exercise	5
Tongue diagnosis index of chronic kidney disease	5
Would foot arch development in children characterize a body maturation process? A prospective longitudinal study	5
The efficacies of non-bismuth containing quadruple therapies in the treatment of first-line anti-Helicobacter pylori across 4-year time interval with changing antibiotics resistance	5
Acupressure reduces the severity of restless legs syndrome in hemodialysis patients: A cluster-randomized crossover pilot study	5
Modulatory effect of cashew (Anacardium occidentale L.) nut supplemented diet on fertility activity of clomiphene citrate in male rats	4
Imaging abnormalities in pediatric neuro-COVID are more diverse than specified	4
AIFM1, negatively regulated by miR-145-5p, aggravates hypoxia-induced cardiomyocyte injury	4
Inhibition of NLRP3 attenuates sodium dextran sulfate-induced inflammatory bowel disease through gut microbiota regulation	4
Hemodynamic monitoring and management of pediatric septic shock	4
Middle cerebral artery velocity is associated with the severity of MRI brain injury in neonates received therapeutic hypothermia	4
Antinociceptive effect and mechanism of supercritical carbon dioxide extract of Aloysia gratissima leaves in mice	4
Arthroscopic diagnosis of long head of biceps tendon instability in refractory anterior shoulder pain: A comparison study between pulley tear and non-tear lesions	4
Pharmacological therapy for Tourette syndrome: What medicine can do and cannot do	4
Living with tics: Nursing care of pediatric Tourette syndrome	4
Innate type 1 immune response, but not IL-17 cells control tuberculosis infection	4
Illnesses in technologically advanced societies due to lack of grounding (earthing)	4
Antibody induction in mice by liposome-displayed recombinant enterotoxigenic Escherichia coli (ETEC) colonization antigens	4
Identification of a novel nonsense homozygous mutation of LINS1 gene in two sisters with intellectual disability, schizophrenia, and anxiety	4
COVID-19 vaccination uptake strongly predicts averted deaths of older people across Europe	4
TP53 common variants and interaction with PPP1R13L and CD3EAP SNPs and lung cancer risk and smoking behavior in a Chinese population	4
Fibroblast growth factor 21 and bone homeostasis	4
Prognosis of chronic kidney disease in patients with non-alcoholic fatty liver disease: a Northeastern Taiwan community medicine research cohort	4
Autonomic modulation and the risk of dementia in a middle-aged cohort: A 17-year follow-up study	4
Protein network analysis and functional enrichment via computational biotechnology unravel molecular and pathogenic mechanisms of kidney stone disease	4
Vertical dimension of occlusion related to mandibular movement during swallowing	4
Comparative analysis of the drug-drug interaction between immunosuppressants, safety and efficacy of rifabutin from rifampicin-based Anti-TB treatment in living donor liver transplant recipients with	4
Novel approach by natural language processing for COVID-19 knowledge discovery	4
Comparison of 3-dimensional postoperative dental movement in Class III surgical correction with and without presurgical orthodontic treatment	4
Effects of Rosa damascena on reproductive improvement, metabolic parameters, liver function and insulin-like growth factor-1 gene expression in estradiol valerate induced polycystic ovarian syndrome i	4
Clinical and genetic approach to renal hypomagnesemia	4
Microbiota and Nod-like receptors balance inflammation and metabolism during obesity and diabetes	4
Is maternal serum inhibin A a good predictor in preterm labor? - Experience from a community hospital in Taiwan	4
The effects of macronutrients metabolism on cellular and organismal aging	4
Outcomes of re-irradiation for oral cavity squamous cell carcinoma	4
Combined therapy with dapagliflozin and entresto offers an additional benefit on improving the heart function in rat after ischemia-reperfusion injury	4
epg5 knockout leads to the impairment of reproductive success and courtship behaviour in a zebrafish model of autophagy-related diseases	4
Mutations in circulating tumor DNA detected in the postoperative period predict poor survival in patients with ovarian cancer	4
Negative times negative equals positive, THEMIS sets the rule on thymic selection and peripheral T cell responses	4
SARS-CoV-2 pandemics: An update of CRISPR in diagnosis and host–virus interaction studies	4