Biomedical Journal

Article	Citations
Polycystic kidney disease increases the stoke incidence in Taiwan: A retrospective population-based cohort study using National Health Insurance Database	158
Aptamer-functionalized liposomes for drug delivery	89
Cell polarity regulators, multifunctional organizers of lymphocyte activation and function	86
Roles of lncRNAs in the transcription regulation of HIV-1	54
One day at a time	46
Autonomic modulation and the risk of dementia in a middle-aged cohort: A 17-year follow-up study	45
Living with tics: Nursing care of pediatric Tourette syndrome	45
Hyperammonemia induces microglial NLRP3 inflammasome activation via mitochondrial oxidative stress in hepatic encephalopathy	44
Fu's Subcutaneous Needling Therapy Significantly Enhances Pain Relief in Sciatica Rats by Promoting Mitochondrial Autophagy	43
HIF-1 AND DEC-1 LEVELS IN ACUTE ISCHAEMIC STROKE PATIENTS: COULD DEC-1 BE A NEW BIOMARKER IN STROKE?	43
Editorial Board	38
Antrodia cinnamomea extract alleviates bleomycin-induced pulmonary fibrosis in mice by inhibiting the mTOR pathway	38
Editorial Board	36
Editorial Board	36
Middle cerebral artery velocity is associated with the severity of MRI brain injury in neonates received therapeutic hypothermia	35
Clinical and genomic insights into persistent carbapenem-resistant Klebsiella pneumoniae bacteremia: risk factors, resistance mechanisms, and treatment challenges	31
m6A landscape is more pervasive when Trypanosoma brucei exits the cell cycle	31
High-throughput proteomics-guided biomarker discovery of hepatocellular carcinoma	30
Bilateral lentiform and caudate nucleus lesions in a child with COVID-19: A case report	29
The establishment of a molecular diagnostic platform for mitochondrial diseases: From conventional to next-generation sequencing	29
When it doesn't run in the blood(vessels) – events involved in vascular disorders	28
Implementation of fecal microbiota transplantation in a medical center for recurrent or refractory Clostridioides difficile infection and report of preliminary outcome	27
Macrophages in the male genital tract	27
Saliva as a diagnostic tool to measure polycyclic aromatic hydrocarbon exposure in dental patients exposed to intimate partner violence (IPV)	27
Comprehensive insight into the alterations in the gut microbiome and the intestinal barrier as a consequence of iron deficiency anaemia	26

The effects of macronutrients metabolism on cellular and organismal aging	25
Tools to measure membrane potential of neurons	24
Influence of acupuncture twisting parameters on analgesic effects mediated by mast cells in AA rat models	24
Lifestyle interventions to delay senescence	24
Long non-coding RNA HAGLROS facilitates the malignant phenotypes of NSCLC cells via repressing miR-100 and up-regulating SMARCA5	23
Glycolytic metabolism and activation of Na+ pumping contribute to extracellular acidification in the central clock of the suprachiasmatic nucleus: Differential glucose sensitivity and utilization betw	23
The binding and specificity of chemokine binding proteins, through the lens of experiment and computation	23
Additional insights on SARS-CoV-2 spike protein variants and red blood cells biology	22
Using time-course as an essential factor to accurately predict sepsis-associated mortality among patients with suspected sepsis	22
Discrepant Treponemal Test Results: Identification of Associated Risk Factors Through Machine Learning Technology in 18-Year Electronic Medical Records and National Claims Data	22
Caffeic acid phenethyl ester inhibits the growth of bladder carcinoma cells by upregulating growth differentiation factor 15	21
Circadian rhythmicity and human health	21
Repeated administration of adipose-derived mesenchymal stem cells added on beneficial effects of empagliflozin on protecting renal function in diabetic kidney disease rat	20
Inhibition of NLRP3 attenuates sodium dextran sulfate-induced inflammatory bowel disease through gut microbiota regulation	20
A panel of miRNAs in the serum extracellular vesicles serve as novel diagnostic biomarkers for MASLD	20
Automatic and human level Graf's type identification for detecting developmental dysplasia of the hip	20
Purinergic signaling: A new front-line determinant of resistance and susceptibility in leishmaniasis	20
“Mpox in MSM: Tackling stigma, minimizing risk factors, exploring pathogenesis, and treatment approaches”	20
Dynamic Regulation of RNA m6A Methylation in the Ribonucleoprotein Complexes in Apicomplexan and Kinetoplastid Parasites	20
Advancements, challenges, and future prospects in clinical hyperpolarized magnetic resonance imaging: A comprehensive review	19
Discharge status validation of the Chang Gung Research database in Taiwan	19
Editorial Board	19
Fecal miRNAs as potential biomarkers for early detection of colorectal cancer: An updated review	19
Sterile inflammation and the NLRP3 inflammasome in cardiometabolic disease	19
Effect of three clinical therapies on cytokines modulation in the hip articular cartilage and bone improvement in rat early osteonecrosis of the femoral head	19
Multifunctional nanozymes for disease diagnosis and therapy	18
Nod-like receptors in inflammatory arthritis	18
A finger in every pie – The versatility of chemokines	18
Low energy shock wave therapy attenuates mitochondrial dysfunction and improves bladder function in HCl induced cystitis in rats	18
Structural, biochemical, and functional properties of the Rap1-Interacting Adaptor Molecule (RIAM)	18
Comparing transvenous coiling and transarterial embolization with Onyx/NBCA for cavernous sinus dural arteriovenous fistulas: A retrospective study in a single center	18
Circ_0011385 knockdown inhibits cell proliferation, migration and invasion, whereas promotes cell apoptosis by regulating miR-330-3p/MYO6 axis in colorectal cancer	18
Systematic analysis of mushroom body-innervating dopaminergic neuron activity in different physiological states in Drosophila	18
Angular super-resolution in X-ray projection radiography using deep neural network: Implementation on rotational angiography	18
Acquired Immune Deficiency Syndrome correlation with SARS-CoV-2 N genotypes	17
The incidence of resistance-associated variants to NS5A in HCV subtypes 1a and 1b in Taiwan	17
Current efforts and challenges facing responses to Monkeypox in United Kingdom	17
Extracellular vesicles in fetal-maternal immune tolerance	17
Endothelial activation, cell-cell interactions, and inflammatory pathways in postoperative atrial fibrillation following cardiac surgery	17
Response to "letter to editor" from Nicolini et al. Regarding "Autonomic modulation and the risk of dementia in a middle-aged cohort: A 17-year follow-up study"	17
Hyperthermic intraperitoneal chemotherapy for recurrent epithelial ovarian cancer	17
Ancient wisdom and modern innovations: Methods of administering healing	17
In vitro axotomy models regulated by ROCK inhibitor for studying neuroregeneration and growth cone morphology	16
SARS-CoV-2 variants – Evolution, spike protein, and vaccines	16
Clinical validation of a saliva-based matrix metalloproteinase-1 rapid strip test for detection of oral cavity cancer	16
Advancing cancer diagnosis and treatment: Integrating molecular biomarkers and emerging technologies	16
Circ_0091579 exerts an oncogenic role in hepatocellular carcinoma via mediating miR-136-5p/TRIM27	16
Long Non-Coding RNAs as Modulators of Metabolic Reprogramming for Endogenous Heart Regeneration: Mechanisms and Therapeutic Potential	16
Inhibition of the 4-hydroxynonenal-regulated JNK/c-Jun pathway improves bleomycin-induced lung fibrosis	15
Strides toward a better understanding of the “Current efforts and challenges facing responses to Monkeypox in United Kingdom”	15

Significant decrease of a master regulator of genes (REST/NRSF) in high-grade squamous intraepithelial lesion and cervical cancer	15
Joint effects of genomic markers and urinary methylation capacity associated with inorganic arsenic metabolism on the occurrence of cancers among residents in arseniasis-endemic areas: A cohort subset	15
Pharmacological therapy for Tourette syndrome: What medicine can do and cannot do	15
Surgery for metastatic epidural spinal cord compression in thoracic spine, anterior or posterior approach?	15
CAN008 prolongs overall survival in patients with newly diagnosed GBM characterized by high tumor mutational burden	15
The epidemiology of invasive fungal infections in transplant recipients	14
Mitochondrial dysfunction route as a possible biomarker and therapy target for human cancer	14
Altered diffusivity of the subarachnoid cisterns in the rat brain following neurological disorders	14
Chronic low-dose REV-ERBs agonist SR9009 mitigates constant light-induced weight gain and insulin resistance via adipogenesis modulation	14
Inherently imperfect, inherently evolving – The pursuit of precision through biomarkers	14
Author reply to letter to the editor “Imaging abnormalities in pediatric neuro-COVID are more diverse than specified”	14
Clinical and functional characteristics of lung surgery-related vocal fold palsy	14
Targeted dexamethasone nano-prodrug for corneal neovascularization management	13
Editorial Board	13
Utilizing nomograms to predict prevalent vertebral fracture risk: An analysis of dysmobility syndrome in a community-dwelling population	13
The best protection is early detection	13
Macrophages of the Heart: Homeostasis and Disease	13
Phosphorylated α-synuclein in diluted human serum as a biomarker for Parkinson's disease	13
Autophagy-induced osteoblast-derived exosomes maintain bone formation and prevent osteoporosis by remodeling gut microbiota-metabolism	13
Clinical significance of incidental common bile duct dilatation in children: A 10-year single medical center experience	13
Mouth opening/breathing is common in sleep apnea and linked to more nocturnal water loss	13
A comprehensive overview of gastric cancer management from a surgical point of view	12
Factors associated with pyloric hypertrophy severity and post-operative feeding and nutritional recovery in infantile hypertrophic pyloric stenosis	12
Blood oxygenation state in COVID-19 patients: Unexplored role of 2,3-bisphosphoglycerate	12
A CD33 frameshift variant is associated with neuromyelitis optica spectrum disorders	12
Comparison of the outcome of emergency endotracheal intubation in the general ward, intensive care unit and emergency department	12
Editorial Board	12
Glomerular disease classification and lesion identification by machine learning	12
Biological functions of extracellular vesicles from mammalian cells	12
Prognosis of chronic kidney disease in patients with non-alcoholic fatty liver disease: a Northeastern Taiwan community medicine research cohort	11
Editorial Board	11
Plasminogen Activator Inhibitor-1 in Systemic Sclerosis: A Nexus of Fibrosis, Vasculopathy, and Senescence	11
Genomic surveillance of SARS-CoV-2 in Taiwan: A perspective on evolutionary data interpretation and sequencing issues	11
Phylogenetic characteristics of Non-SARS human coronavirus in southern Taiwan, 2012–2013	11
Complementary effects of Orthosiphon stamineus standardized ethanolic extract and rosmarinic acid in combination with gemcitabine on pancreatic cancer	11
Curcumin suppresses RANKL-induced osteoclast precursor autophagy in osteoclastogenesis by inhibiting RANK signaling and downstream JNK-BCL2-Beclin1 pathway	11
Practical applications of grounding to support health	11
ShinySC: an R/Shiny-based desktop application for seamless analysis of scRNA-Seq data	11
Infection control operations of a large hospital in Taiwan to prevent nosocomial outbreaks during COVID-19 pandemic	10
Antibody induction in mice by liposome-displayed recombinant enterotoxigenic Escherichia coli (ETEC) colonization antigens	10
Negative regulatory NLRs mitigate inflammation via NF-κB pathway signaling in inflammatory bowel disease	10
COVID-19 vaccination uptake strongly predicts averted deaths of older people across Europe	10
The 2022 nobel prize in physiology or medicine awarded for the decoding of the complete ancient human genome	10
BrainView: A Cloud-based Deep Learning System for Brain Image Segmentation, Tumor Detection and Visualization	10
Immunosenescence, gut dysbiosis, and chronic kidney disease: Interplay and implications for clinical management	10
The clockwork macrophage: timing in innate immunity	10
Editorial Board	10
Editorial Board	10
LncRNAs and asymmetric cell division: The epigenetic mechanisms	10
SLC7A11-HSPB1 Axis: A Novel Mechanism for Hepatocellular Carcinoma Progression and Ferroptosis Regulation	9
The role of endocytic trafficking in antigen T cell receptor activation	9
Effects of light, electromagnetic fields and water on biological rhythms	9
Genome-wide association study identifies DRAM1 associated with Tourette syndrome in Taiwan	9
SARS-CoV-2 pandemics: An update of CRISPR in diagnosis and host–virus interaction studies	9
Techniques to evaluate surfactant activity for a personalized therapy of RDS neonates	9
A review for cell and particle tracking on microscopy images using algorithms and deep learning technologies	9
Olesoxime protects against cisplatin-induced acute kidney injury by attenuating mitochondrial dysfunction	9
Applications of three-dimensional imaging techniques in craniomaxillofacial surgery: A literature review	9
Real-world effectiveness of intravitreal dexamethasone implants - Comparison between eyes eligible and ineligible for clinical trials and their associated outcomes	9
Clinical studies on coronavirus disease 2019 (COVID-19) in the WHO registry network	9
Interferon-alpha and MxA inhibit BK polyomavirus replication by interaction with polyomavirus large T antigen	9
Deep learning significantly boosts CRT response prediction using synthetic longitudinal strain data: Training on synthetic data and testing on real patients	9
Kinship analysis of type 2 diabetes mellitus familial aggregation in Taiwan	9
Gut mycobiome in metabolic diseases: Mechanisms and clinical implication	9
The next generation of healthcare ecosystem in the metaverse	9
PAI-1 is a common driver of aging and diverse diseases	9
Small and mighty – microRNAs pulling the strings	9
The Role of Blue Light-Filtering and Premium Intraocular Lenses on Postoperative Falls: A Nationwide Target Trial Emulation in Taiwan	9
Editorial Board	9
Differential longitudinal effects of frequent sweetened food consumption at different exposure ages on child cognitive, language, and motor development	8
The efficacies of non-bismuth containing quadruple therapies in the treatment of first-line anti-Helicobacter pylori across 4-year time interval with changing antibiotics resistance	8
Role of purinoreceptors in the release of extracellular vesicles and consequences on immune response and cancer progression	8
Different impacts of common risk factors associated with thrombocytopenia in patients with hepatitis B virus and hepatitis C virus infection	8
The International Week of Surfactant Research: Increasing knowledge about surfactant and unexploited opportunities	8
Apremilast ameliorates acute respiratory distress syndrome by inhibiting neutrophil-induced oxidative stress	8
Novel approach by natural language processing for COVID-19 knowledge discovery	8
MicroRNAs (−146a, −21 and −34a) are diagnostic and prognostic biomarkers for diabetic retinopathy	8
Mitochondrial bioenergetics deficiency in cisd-1 mutants is linked to AMPK-mediated lipid metabolism	8
c-MYC/METTL3/LINC01006 positive feedback loop promotes migration, invasion and proliferation of non-small cell lung cancer	8
Serum CA-125 and renal impairment in patients undergoing hyperthermic intraperitoneal chemotherapy	7

An area of greatest vulnerability - Recent advances in kidney injury	7
Rhythms under tension: Circadian clocks in an Unsynced Society	7
Reading the epitranscriptome of the human malaria parasite	7
Charting new territory: The Plasmodium falciparum tRNA modification landscape	7
Elastase Reduces Background Autofluorescence in ALK Fluorescence In Situ Hybridization Assays for Lung Cancers	7
Basic implications on three pathways associated with SARS-CoV-2	7
Mutations in circulating tumor DNA detected in the postoperative period predict poor survival in patients with ovarian cancer	7
Editorial Board	7
Increased macrophage activation marker soluble CD163 is associated with graft dysfunction and metabolic derangements in renal transplant recipients	7
Disposition of embryos from women who only produced morphologically poor embryos on day three	7
The role of gut fungi in Clostridioides difficile infection	7
Reply: Serum CA-125 and renal impairment in patients undergoing hyperthermic intraperitoneal chemotherapy	7
Cartilage-specific knockout of miRNA-128a expression normalizes the expression of circadian clock genes (CCGs) and mitigates the severity of osteoarthritis	7
Afterhyperpolarization potential modulated by local [K+]o in K+ diffusion-restricted extracellular space in the central clock of suprachiasmatic nucleus	7
Comprehensive functional genomic analyses link APC somatic mutation and mRNA-miRNA networks to the clinical outcome of stage-III colorectal cancer patients	7
Palatal hybrid surgery for obstructive sleep apnea-state-of-the-art annotation of uvulopalatopharyngoplasty	7
Human adenovirus infections in pediatric population - An update on clinico–pathologic correlation	7
LncRNA OIP5-AS1 reduces renal epithelial cell apoptosis in cisplatin-induced AKI by regulating the miR-144-5p/PKM2 axis	7
Modification of brain waves and sleep parameters by Citrus reticulata Blanco. cv. Sai-Nam-Phueng essential oil	7
Hepatocyte nuclear factor 4 located in different developmental stages of Schistosoma japonicum and involved in important metabolic pathways	7
Differential bicistronic gene translation mediated by the internal ribosome entry site element of encephalomyocarditis virus	7
Would foot arch development in children characterize a body maturation process? A prospective longitudinal study	7
Using A modified quickert procedure combined with prolapsed fat and preseptal orbicularis muscle removal to correct involutional lower eyelid entropion in Asians	7
Percentage genome change and chromosome 7q amplification predict sorafenib response in advanced hepatocellular carcinoma	7
Impact of fasting & ketogenic interventions on the NLRP3 inflammasome: A narrative review	7
Inherited immunodeficiencies associated with proximal and distal defects in T cell receptor signaling and co-signaling	6
Editorial Board	6
Impact of Vertical Facial Patterns on Three-Dimensional Surgical Outcomes and Stability in Skeletal Class II Malocclusion	6
Editorial Board	6
Prevention and treatment of COVID-19 infection by earthing	6
Strategies to protect surfactant and enhance its activity	6
Application of Solidago chilensis and laser improved the repair of burns in diabetic rats	6
A recipe for a good clinical pulmonary surfactant	6
miRNA-mediated regulation of clock gene expression in men and women with colorectal cancer and possible consequences for disease management	6
Changing life styles for children with Tourette syndrome	6
The combination of low level laser therapy and efavirenz drastically reduces HIV infection in TZM-bl cells	6
Correlation of SALL1 with CEUS parameters and immune escape in thyroid carcinoma	6
Regenerative medicine for male infertility: A focus on stem cell niche injury models	6
Evaluation of clinical relevance and underlying pathology for hemodynamic compromise in acute small subcortical infarction using MRI-based neuroimaging markers	6
Postnatal intestinal mucosa and gut microbial composition develop hand in hand: A mouse study	6
TP53 common variants and interaction with PPP1R13L and CD3EAP SNPs and lung cancer risk and smoking behavior in a Chinese population	6
Chronobioethics: Symphony of biological clocks observed by 7-day/24-h ambulatory blood pressure monitoring and cardiovascular health	6
MicroRNA-based signature for diagnosis and prognosis of colorectal cancer using residuum of fecal immunochemical test	6
AIFM1, negatively regulated by miR-145-5p, aggravates hypoxia-induced cardiomyocyte injury	6
The respiratory impacts of air pollution in children: Global and domestic (Taiwan) situation	6
IRE1α-mediated endoplasmic reticulum stress response regulates oxidative damage in CYP4V2 deficient human retinal pigment epithelial cells	6
The role of excess charge mitigation in electromagnetic hygiene: An integrative review	6
Clinical and laboratory predictors for disease progression in patients with COVID-19: A multi-center cohort study	5
Neuropeptide FF Receptor 2 Overexpression Aggravates Lipid Accumulation and Metabolic Dysfunction in Mice with Diet-Induced Metabolic Stress	5
Personalized medicine: From diagnostic to adaptive	5
Unveiling the mycobiota: The fungal frontier of human health	5
Secreted proteins encoded by super enhancer-driven genes could be promising biomarkers for early detection of esophageal squamous cell carcinoma	5
Dynamic monitoring of kidney injury status over 3 days in the intensive care unit as a sepsis phenotype associated with hospital mortality and hyperinflammation	5
LAMA5: A new pathogenic gene for non-syndromic cleft lip with or without cleft palate	5
The effects of bone-substitute augmentation on treatment of osteoporotic intertrochanteric fractures	5
Evaluation of recurrence risk in patients with papillary thyroid cancer through tumor-node-metastasis staging: A single-center observational study in Taiwan	5
After me, the deluge	5
Minimal invasive fixation following with radiotherapy for radiosensitive unstable metastatic spine	5
High levels estradiol affect blastocyst implantation and post-implantation development directly in mice	5
Suppression of MGAT3 expression and the epithelial–mesenchymal transition of lung cancer cells by miR-188-5p	5
He protec but he also attac – Inflammasomes swinging the sword	5
Effects of Rosa damascena on reproductive improvement, metabolic parameters, liver function and insulin-like growth factor-1 gene expression in estradiol valerate induced polycystic ovarian syndrome i	5
Development and validation of a deep-learning-based pediatric early warning system: A single-center study	5
The correlation of small fiber neuropathy with pain intensity and age in patients with Fabry's disease: A cross sectional study within a large Taiwanese family	5
High-fat diet-induced increase in glucocorticoids contributes to adipogenesis in obese mice	5
A newly designed Flexible Hydrated-Hardening Bone Graft (FHBG) promotes bone regeneration and in vivo calvarial repair	5
Mpox: A narrative review on current knowledge	4
Breast cancer larger than 2.5 cm with tumor-free radioisotope-hot sentinel nodes has higher risk of non-hot axillary lymph node metastasis	4
Gut microbiota and clinical response to immune checkpoint inhibitor therapy in patients with advanced cancer	4
Long noncoding RNA TUG1 promotes malignant progression of osteosarcoma by enhancing ZBTB7C expression	4
Long non-coding RNA TTTY15 sponges miR-520a-3p to exacerbate neural apoptosis induced by cerebral ischemia/reperfusion via targeting IRF9 both in vivo and in vitro	4
Protein network analysis and functional enrichment via computational biotechnology unravel molecular and pathogenic mechanisms of kidney stone disease	4
Increased risk of migraine among patients with hidradenitis suppurativa: A US multi-center cohort study	4
Altered purinergic P2X7 and A2B receptors signaling limits macrophage-mediated host defense in schistosomiasis	4
Immunogenicity of second booster-dose COVID-19 mRNA vaccine among older adults in Taiwan	4
Y-chromosome genes associated with sertoli cell-only syndrome identified by array comparative genome hybridization	4
Lipopeptides against COVID-19 RNA-dependent RNA polymerase using molecular docking	4
The effect and mechanism of astragalus polysaccharides on T cells and macrophages in inhibiting prostate cancer	4
Application of extended reality in pediatric neurosurgery: A comprehensive review	4
Vomocytosis of Cryptococcus neoformans from Macrophages: from discovery to current understanding	4
Pediatric care for children with developmental coordination disorder, can we do better?	4
Physical attributes of salivary calcium particles and their interaction with gingival epithelium	4
Study of polymethylmethacrylate/tricalcium silicate composite cement for orthopedic application	4
The ratio of remaining to expected small bowel length predicts enteral autonomy in pediatric patients with short bowel syndrome	4
Acupressure reduces the severity of restless legs syndrome in hemodialysis patients: A cluster-randomized crossover pilot study	4
Clinical feature, image findings and outcome of hepatosplenic candidiasis in patients with acute myeloid leukemia	4
Short-term and long-term psychological impact and quality of life of patients undergoing orthognathic surgery	4
Influence of electromagnetic fields on the circadian rhythm: Implications for human health and disease	4
A concerted effort combating hepatitis	4
Combined therapy with dapagliflozin and entresto offers an additional benefit on improving the heart function in rat after ischemia-reperfusion injury	4
Msi2 enhances muscle dysfunction in a myotonic dystrophy type 1 mouse model	4
ECG-surv: A deep learning-based model to predict time to 1-year mortality from 12-lead electrocardiogram	4
Cytidine deaminase enhances liver cancer invasion by modulating epithelial-mesenchymal transition via NFκB signaling	4
Integrating comprehensive genomic profiling in the management of oncology patients: Applications and challenges in Taiwan	4