Biomedical Journal

Article	Citations
DNA copy number variation: Main characteristics, evolutionary significance, and pathological aspects	120
Innate immunity drives pathogenesis of rheumatoid arthritis	109
Understanding the role of neutrophils in acute respiratory distress syndrome	100
Human adenovirus infections in pediatric population - An update on clinico–pathologic correlation	83
G6PD: A hub for metabolic reprogramming and redox signaling in cancer	47
Development of multi-epitope peptide-based vaccines against SARS-CoV-2	45
Lopinavir/ritonavir: Repurposing an old drug for HIV infection in COVID-19 treatment	44
Perilla (Perilla frutescens) leaf extract inhibits SARS-CoV-2 via direct virus inactivation	43
SARS-CoV-2, the other face to SARS-CoV and MERS-CoV: Future predictions	37
LncRNA MALAT1 promotes breast cancer progression and doxorubicin resistance via regulating miR-570–3p	37
Neutralizing monoclonal antibodies for COVID-19 treatment and prevention	37
RASopathies: From germline mutations to somatic and multigenic diseases	36
Effects of physical exercise on children with attention deficit hyperactivity disorder	34
SARS-CoV-2 variants – Evolution, spike protein, and vaccines	34
Exploring algae and cyanobacteria as a promising natural source of antiviral drug against SARS-CoV-2	31
Lymphoid Tissue inducer (LTi) cell ontogeny and functioning in embryo and adult	30
Breath volatile organic compounds (VOCs) as biomarkers for the diagnosis of pathological conditions: A review	30
Exposure to PM2.5 and PM10 and COVID-19 infection rates and mortality: A one-year observational study in Poland	29
The role of GPR56/ADGRG1 in health and disease	29
Effects of electronic cigarette aerosol exposure on oral and systemic health	28
3D culture models to study SARS-CoV-2 infectivity and antiviral candidates: From spheroids to bioprinting	27
Phytochemicals against SARS-CoV as potential drug leads	27
Glomerular disease classification and lesion identification by machine learning	27
Germline STAT3 gain-of-function mutations in primary immunodeficiency: Impact on the cellular and clinical phenotype	27
Role of bacterial infections in extracellular vesicles release and impact on immune response	25

Artificial neural network and logistic regression modelling to characterize COVID-19 infected patients in local areas of Iran	25
The respiratory impacts of air pollution in children: Global and domestic (Taiwan) situation	25
Influence of electromagnetic fields on the circadian rhythm: Implications for human health and disease	24
Immune checkpoint deficiencies and autoimmune lymphoproliferative syndromes	24
Modified ELISA for antibody avidity evaluation: The need for standardization	24
Brain stimulation treatments in epilepsy: Basic mechanisms and clinical advances	23
The genetic landscape of the FAS pathway deficiencies	22
Immunotherapy in older patients with cancer	22
Pediatric care for children with developmental coordination disorder, can we do better?	22
Cellular senescence and the host immune system in aging and age-related disorders	21
Sex hormone regulation of innate lymphoid cells	21
Targeting mitochondrial bioenergetics as a promising therapeutic strategy in metabolic and neurodegenerative diseases	21
A recipe for a good clinical pulmonary surfactant	20
The role and mechanism of CARD9 gene polymorphism in diseases	20
Type 1 innate lymphoid cells: Soldiers at the front line of immunity	19
The role of hypoxia-induced long noncoding RNAs (lncRNAs) in tumorigenesis and metastasis	19
Role of SARS-CoV-2 and ACE2 variations in COVID-19	19
The Notch signaling pathway involvement in innate lymphoid cell biology	19
Updates on the ketogenic diet therapy for pediatric epilepsy	18
Cell polarity regulators, multifunctional organizers of lymphocyte activation and function	17
Development and validation of a deep-learning-based pediatric early warning system: A single-center study	17
Intravascular Large B-cell lymphoma: A case series and review of literatures	17
Roles of lncRNAs in the transcription regulation of HIV-1	16
A novel CAD/CAM composite occlusal splint for intraoperative verification in single-splint two-jaw orthognathic surgery	16
Personalized medicine: From diagnostic to adaptive	15
Discovery of serum biomarkers for diagnosis of tuberculosis by NMR metabolomics including cross-validation with a second cohort	15
Discharge status validation of the Chang Gung Research database in Taiwan	15
A multicompartment vascular implant of electrospun wintergreen oil/ polycaprolactone fibers coated with poly(ethylene oxide)	15
Modification of brain waves and sleep parameters by Citrus reticulata Blanco. cv. Sai-Nam-Phueng essential oil	14
5-day multi-session intermittent theta burst stimulation over bilateral posterior superior temporal sulci in adults with autism-a pilot study	14
Immunoinformatics prediction of potential B-cell and T-cell epitopes as effective vaccine candidates for eliciting immunogenic responses against Epstein–Barr virus	14
Impact of prepregnancy body mass index on pregnancy outcomes, incidence of urinary incontinence and quality of life during pregnancy - An observational cohort study	14
Circ_0091579 exerts an oncogenic role in hepatocellular carcinoma via mediating miR-136-5p/TRIM27	14
Postnatal intestinal mucosa and gut microbial composition develop hand in hand: A mouse study	14
Pristimerin exerts antitumor activity against MDA-MB-231 triple-negative breast cancer cells by reversing of epithelial-mesenchymal transition via downregulation of integrin β3	14
Suppression of MGAT3 expression and the epithelial–mesenchymal transition of lung cancer cells by miR-188-5p	14
Current and future applications of fecal microbiota transplantation for children	14
Cell therapy in vascularized composite allotransplantation	13
Metabolomics as a promising tool for improving understanding of multiple sclerosis: A review of recent advances	13
Typical and atypical enteropathogenic Escherichia coli in children with acute diarrhoea: Changing trend in East Delhi	13
Time course and epidemiological features of COVID-19 resurgence due to cold-chain food or packaging contamination	13
A brief review on potential application of mesenchymal stem cell and secretome in combating mortality and morbidity in COVID-19 patients	13
Current understanding of the genetics of Tourette syndrome	13
Bone marrow-derived mesenchymal stem cells transplantation ameliorates renal injury through anti-fibrotic and anti-inflammatory effects in chronic experimental renovascular disease	13
Spectrum of neuroimaging mimics in children with COVID-19 infection	13
Low energy shock wave therapy attenuates mitochondrial dysfunction and improves bladder function in HCl induced cystitis in rats	13
Tools to measure membrane potential of neurons	13
Therapeutic effect of bone marrow mesenchymal stem cells in a rat model of carbon tetrachloride induced liver fibrosis	13
3-Hydroxybenzaldehyde and 4-Hydroxybenzaldehyde enhance survival of mouse astrocytes treated with Angiostrongylus cantonensis young adults excretory/secretory products	12
Complementary effects of Orthosiphon stamineus standardized ethanolic extract and rosmarinic acid in combination with gemcitabine on pancreatic cancer	12

Tourette disorder and sleep	12
High levels estradiol affect blastocyst implantation and post-implantation development directly in mice	12
COVID-19 and gastrointestinal system: A brief review	12
Bladder volume reproducibility after water consumption in patients with prostate cancer undergoing radiotherapy: A systematic review and meta-analysis	12
The role of endocytic trafficking in antigen T cell receptor activation	11
Endoscopic transcanal removal of external auditory canal osteomas	11
Functional roles of non-coding RNAs regulated by thyroid hormones in liver cancer	11
Evaluation of recurrence risk in patients with papillary thyroid cancer through tumor-node-metastasis staging: A single-center observational study in Taiwan	11
Current efforts and challenges facing responses to Monkeypox in United Kingdom	11
Strategies to protect surfactant and enhance its activity	11
LncRNA OIP5-AS1 reduces renal epithelial cell apoptosis in cisplatin-induced AKI by regulating the miR-144-5p/PKM2 axis	10
Comparison of the Roche cobas 6800 SARS-CoV-2 test and the Taiwan CDC protocol for the molecular diagnosis of COVID-19	10
Circ_0011385 knockdown inhibits cell proliferation, migration and invasion, whereas promotes cell apoptosis by regulating miR-330-3p/MYO6 axis in colorectal cancer	10
Recovery of walking ability in stroke patients through postacute care rehabilitation	10
Phosphorylated α-synuclein in diluted human serum as a biomarker for Parkinson's disease	10
Association of preoperative frailty and postoperative delirium in older cancer patients undergoing elective abdominal surgery: A prospective observational study in Taiwan	10
Applications of three-dimensional imaging techniques in craniomaxillofacial surgery: A literature review	10
Cardiac troponin elevation in patients with influenza virus infections	10
Negative regulatory NLRs mitigate inflammation via NF-κB pathway signaling in inflammatory bowel disease	10
Immunosenescence, gut dysbiosis, and chronic kidney disease: Interplay and implications for clinical management	10
Hyperthermic intraperitoneal chemotherapy for recurrent epithelial ovarian cancer	10
Integrative immunoinformatics paradigm for predicting potential B-cell and T-cell epitopes as viable candidates for subunit vaccine design against COVID-19 virulence	10
Inhibition of NLRP3 attenuates sodium dextran sulfate-induced inflammatory bowel disease through gut microbiota regulation	10
Circulating tumor cell enumeration for improved screening and disease detection of patients with colorectal cancer	10
Modified natriuretic peptides and their potential roles in cancer treatment	10
MicroRNAs (−146a, −21 and −34a) are diagnostic and prognostic biomarkers for diabetic retinopathy	9
Regenerative medicine for male infertility: A focus on stem cell niche injury models	9
Long non-coding RNA LINC01559 serves as a competing endogenous RNA accelerating triple-negative breast cancer progression	9
Different impacts of common risk factors associated with thrombocytopenia in patients with hepatitis B virus and hepatitis C virus infection	9
Sterile inflammation and the NLRP3 inflammasome in cardiometabolic disease	9
Hemodynamic monitoring and management of pediatric septic shock	9
Race with virus evolution: The development and application of mRNA vaccines against SARS-CoV-2	9
Antisiphon device: A review of existing mechanisms and clinical applications to prevent overdrainage in shunted hydrocephalic patients	9
Infection control operations of a large hospital in Taiwan to prevent nosocomial outbreaks during COVID-19 pandemic	9
Short-term and long-term psychological impact and quality of life of patients undergoing orthognathic surgery	9
Clinical features, laboratory findings and persistence of virus in 10 children with coronavirus disease 2019 (COVID-19)	8
c-MYC/METTL3/LINC01006 positive feedback loop promotes migration, invasion and proliferation of non-small cell lung cancer	8
Undergraduates’ preparedness for practice is associated with professional identity and perception of educational environment: A validation study	8
MicroRNA-based signature for diagnosis and prognosis of colorectal cancer using residuum of fecal immunochemical test	8
Comparison of the outcome of emergency endotracheal intubation in the general ward, intensive care unit and emergency department	8
Combined therapy with dapagliflozin and entresto offers an additional benefit on improving the heart function in rat after ischemia-reperfusion injury	8
Apremilast ameliorates acute respiratory distress syndrome by inhibiting neutrophil-induced oxidative stress	8
Negative times negative equals positive, THEMIS sets the rule on thymic selection and peripheral T cell responses	8
Acupressure reduces the severity of restless legs syndrome in hemodialysis patients: A cluster-randomized crossover pilot study	8
The Yin and the Yang of extracellular vesicles during viral infections	8
The combination of low level laser therapy and efavirenz drastically reduces HIV infection in TZM-bl cells	8
The NLR member CIITA: Master controller of adaptive and intrinsic immunity and unexpected tool in cancer immunotherapy	8
Innate type 1 immune response, but not IL-17 cells control tuberculosis infection	8
Gastrodia elata and parishin ameliorate aging induced ‘leaky gut’ in mice: Correlation with gut microbiota	8
A review for cell and particle tracking on microscopy images using algorithms and deep learning technologies	8
Performance of two frailty screening tools among patients with cancer in Taiwan	8
Fibroblast growth factor 21 and bone homeostasis	8
Progesterone eliminates 17β-estradiol-Mediated cardioprotection against diabetic cardiovascular dysfunction in ovariectomized rats	8
Leptospirosis kidney disease: Evolution from acute to chronic kidney disease	7
Stereotactic body radiotherapy plus cetuximab for previously irradiated un-resectable head and neck cancer	7
Differential inflammatory response of men and women subjected to an acute resistance exercise	7
Eligibility for live, interactive otolaryngology telemedicine: 19-Month experience before and during the COVID-19 pandemic in Taiwan	7
Hyperammonemia induces microglial NLRP3 inflammasome activation via mitochondrial oxidative stress in hepatic encephalopathy	7
Population based norms for the box and blocks test in healthy right-handed Taiwanese adults	7
Scaling the tips of the ALPS	7
Management of intracranial vertebral artery stenosis with ipsilateral vertebral artery hypoplasia and contralateral vertebral artery occlusion via type 2 proatlantal intersegmental artery	7
Microbiota and Nod-like receptors balance inflammation and metabolism during obesity and diabetes	7
Implementation of fecal microbiota transplantation in a medical center for recurrent or refractory Clostridioides difficile infection and report of preliminary outcome	7
Comparison of the effects between lasers applied to myofascial trigger points and to classical acupoints for patients with cervical myofascial pain syndrome	7
Techniques to evaluate surfactant activity for a personalized therapy of RDS neonates	7
Clinical and genetic approach to renal hypomagnesemia	7
Diffusion tensor imaging for the differential diagnosis of Parkinsonism by machine learning	7
Caffeic acid phenethyl ester inhibits the growth of bladder carcinoma cells by upregulating growth differentiation factor 15	7
Vertical dimension of occlusion related to mandibular movement during swallowing	7
Protein network analysis and functional enrichment via computational biotechnology unravel molecular and pathogenic mechanisms of kidney stone disease	7
The efficacies of non-bismuth containing quadruple therapies in the treatment of first-line anti-Helicobacter pylori across 4-year time interval with changing antibiotics resistance	6
Outcome and cost analysis of primary total knee arthroplasty in end-stage renal disease patients: A nationwide population-based study	6
The spontaneous immortalization probability of mammalian cell culture strains, as their proliferative capacity, correlates with species body mass, not longevity	6
Emerging mutation in SARS-CoV-2 spike: Widening distribution over time in different geographic areas	6
TP53 common variants and interaction with PPP1R13L and CD3EAP SNPs and lung cancer risk and smoking behavior in a Chinese population	6
Would foot arch development in children characterize a body maturation process? A prospective longitudinal study	6
Developing and validating clinical features-based machine learning algorithms to predict influenza infection in influenza-like illness patients	6
Lipopeptides against COVID-19 RNA-dependent RNA polymerase using molecular docking	6
Comparative analysis of the drug-drug interaction between immunosuppressants, safety and efficacy of rifabutin from rifampicin-based Anti-TB treatment in living donor liver transplant recipients with	6
Small cell neuroendocrine carcinoma of the cervix: From molecular basis to therapeutic advances	6

Dynamic monitoring of kidney injury status over 3 days in the intensive care unit as a sepsis phenotype associated with hospital mortality and hyperinflammation	6
Identification of a novel nonsense homozygous mutation of LINS1 gene in two sisters with intellectual disability, schizophrenia, and anxiety	6
AIFM1, negatively regulated by miR-145-5p, aggravates hypoxia-induced cardiomyocyte injury	6
Inherited immunodeficiencies associated with proximal and distal defects in T cell receptor signaling and co-signaling	6
Stress while lacking of control induces ventral hippocampal autophagic flux hyperactivity and a depression-like behavior	6
Impact of fasting & ketogenic interventions on the NLRP3 inflammasome: A narrative review	6
Study of polymethylmethacrylate/tricalcium silicate composite cement for orthopedic application	6
Phospholipases A2 as biomarkers in acute respiratory distress syndrome	6
High fructose induced osteogenic differentiation of human valve interstitial cells via activating PI3K/AKT/mitochondria signaling	6
Application of Solidago chilensis and laser improved the repair of burns in diabetic rats	6
Long non-coding RNA HAGLROS facilitates the malignant phenotypes of NSCLC cells via repressing miR-100 and up-regulating SMARCA5	6
Comparison of physical electrical conductivity and acupuncture de-qi sensation between stainless steel needling and supercritical fluid-treated needling	6
Effect of oral nitrite administration on gene expression of SNARE proteins involved in insulin secretion from pancreatic islets of male type 2 diabetic rats	6
Mutations in circulating tumor DNA detected in the postoperative period predict poor survival in patients with ovarian cancer	6
The effects of macronutrients metabolism on cellular and organismal aging	5
The next generation of healthcare ecosystem in the metaverse	5
Grounding – The universal anti-inflammatory remedy	5
Purinergic signaling: A new front-line determinant of resistance and susceptibility in leishmaniasis	5
Y-chromosome genes associated with sertoli cell-only syndrome identified by array comparative genome hybridization	5
Exosomes in multiple sclerosis and Alzheimer's disease – Adversary and ally	5
NLRX1: Versatile functions of a mitochondrial NLR protein that controls mitophagy	5
Neurotrophins BDNF and NT4/5 accelerate dental pulp stem cell migration	5
Tongue diagnosis index of chronic kidney disease	5
The effects of bone-substitute augmentation on treatment of osteoporotic intertrochanteric fractures	5
Assessment of vascular and endothelial function in Kawasaki disease	5
Hypocalcemia: A key biomarker in hospitalized COVID-19 patients	5
Brain stem death induces pro-inflammatory cytokine production and cardiac dysfunction in sheep model	5
Clinical characteristics associated with the severity of Clostridium [Clostridioides] difficile infection in a tertiary teaching hospital from Mexico	5
Clinical manifestations and risk factors of campylobacter gastroenteritis in children in Taiwan	5
Novel approach by natural language processing for COVID-19 knowledge discovery	5
Peto's paradox: Nature has used multiple strategies to keep cancer at bay while evolving long lifespans and large body masses. A systematic review	5
In-vitro and in-vivo functional observation studies to establish therapeutic potential of alpha-ketoglutarate against methotrexate induced liver injury	5
Prevention and treatment of COVID-19 infection by earthing	5
One-year stability of the mandibular advancement and counterclockwise rotation for correction of the skeletal class II malocclusion and high mandibular plane angle: Dental and skeletal aspect	5
Repeated administration of adipose-derived mesenchymal stem cells added on beneficial effects of empagliflozin on protecting renal function in diabetic kidney disease rat	5
Association between serum bilirubin levels and progression of albuminuria in Taiwanese with type 2 diabetes mellitus	5
epg5 knockout leads to the impairment of reproductive success and courtship behaviour in a zebrafish model of autophagy-related diseases	5
Comparison of 3-dimensional postoperative dental movement in Class III surgical correction with and without presurgical orthodontic treatment	5
Investigation of echocardiographic characteristics and predictors for persistent defects of patent foramen ovale or patent ductus arteriosus in Chinese newborns	5
Outcomes of re-irradiation for oral cavity squamous cell carcinoma	5
Antibody induction in mice by liposome-displayed recombinant enterotoxigenic Escherichia coli (ETEC) colonization antigens	5
The clinical and imaging features of FLNA positive and negative periventricular nodular heterotopia	4
Middle cerebral artery velocity is associated with the severity of MRI brain injury in neonates received therapeutic hypothermia	4
The effects of intermittent hypoxia on hepatic expression of fatty acid translocase CD36 in lean and diet-induced obese mice	4
Antinociceptive effect and mechanism of supercritical carbon dioxide extract of Aloysia gratissima leaves in mice	4
Mouth opening/breathing is common in sleep apnea and linked to more nocturnal water loss	4
Autonomic modulation and the risk of dementia in a middle-aged cohort: A 17-year follow-up study	4
Intercellular transfer of MHC molecules in T cell alloimmunity and allotransplantation	4
Inhibition of infantile hemangioma growth and promotion of apoptosis via VEGF/PI3K/Akt axis by 755-nm long-pulse alexandrite laser	4
SARS-CoV-2 pandemics: An update of CRISPR in diagnosis and host–virus interaction studies	4
Lidocaine reinforces the anti-inflammatory action of dexamethasone on myeloid and epithelial cells activated by inflammatory cytokines or SARS-CoV-2 infection	4
Modulatory effect of cashew (Anacardium occidentale L.) nut supplemented diet on fertility activity of clomiphene citrate in male rats	4
Curcumin suppresses RANKL-induced osteoclast precursor autophagy in osteoclastogenesis by inhibiting RANK signaling and downstream JNK-BCL2-Beclin1 pathway	4
Practical applications of grounding to support health	4
A CD33 frameshift variant is associated with neuromyelitis optica spectrum disorders	4
Gut microbiota and clinical response to immune checkpoint inhibitor therapy in patients with advanced cancer	4
Arthroscopic diagnosis of long head of biceps tendon instability in refractory anterior shoulder pain: A comparison study between pulley tear and non-tear lesions	4
Atrophy, hypometabolism and implication regarding pathology in late-life major depression with suspected non-alzheimer pathophysiology (SNAP)	4
Utilizing nomograms to predict prevalent vertebral fracture risk: An analysis of dysmobility syndrome in a community-dwelling population	4
Joint effects of genomic markers and urinary methylation capacity associated with inorganic arsenic metabolism on the occurrence of cancers among residents in arseniasis-endemic areas: A cohort subset	4
Clinical validation of a saliva-based matrix metalloproteinase-1 rapid strip test for detection of oral cavity cancer	4
Surgery for metastatic epidural spinal cord compression in thoracic spine, anterior or posterior approach?	4
Gut mycobiome in metabolic diseases: Mechanisms and clinical implication	4
Imaging abnormalities in pediatric neuro-COVID are more diverse than specified	4
Non-neutralizing functions in anti-SARS-CoV-2 IgG antibodies	4
COVID-19 vaccination uptake strongly predicts averted deaths of older people across Europe	4
Prognosis of chronic kidney disease in patients with non-alcoholic fatty liver disease: a Northeastern Taiwan community medicine research cohort	4
Physiological and therapeutic relevance of T cell receptor-mediated antigen trogocytosis	4
Long non-coding RNA TTTY15 sponges miR-520a-3p to exacerbate neural apoptosis induced by cerebral ischemia/reperfusion via targeting IRF9 both in vivo and in vitro	4
Living with tics: Nursing care of pediatric Tourette syndrome	4
Pharmacological therapy for Tourette syndrome: What medicine can do and cannot do	4
Significant decrease of a master regulator of genes (REST/NRSF) in high-grade squamous intraepithelial lesion and cervical cancer	4
Illnesses in technologically advanced societies due to lack of grounding (earthing)	4
Evaluation of clinical relevance and underlying pathology for hemodynamic compromise in acute small subcortical infarction using MRI-based neuroimaging markers	4
Multifunctional nanozymes for disease diagnosis and therapy	4