Biomedical Journal

Article	Citations
Polycystic kidney disease increases the stoke incidence in Taiwan: A retrospective population-based cohort study using National Health Insurance Database	135
HIF-1 AND DEC-1 LEVELS IN ACUTE ISCHAEMIC STROKE PATIENTS: COULD DEC-1 BE A NEW BIOMARKER IN STROKE?	63
Fu's Subcutaneous Needling Therapy Significantly Enhances Pain Relief in Sciatica Rats by Promoting Mitochondrial Autophagy	57
New concepts for glioblastoma vaccine immunotherapy	56
Autonomic modulation and the risk of dementia in a middle-aged cohort: A 17-year follow-up study	52
Antrodia cinnamomea extract alleviates bleomycin-induced pulmonary fibrosis in mice by inhibiting the mTOR pathway	50
Hyperammonemia induces microglial NLRP3 inflammasome activation via mitochondrial oxidative stress in hepatic encephalopathy	49
Roles of lncRNAs in the transcription regulation of HIV-1	43
Aptamer-functionalized liposomes for drug delivery	42
m6A landscape is more pervasive when Trypanosoma brucei exits the cell cycle	41
When it doesn't run in the blood(vessels) – events involved in vascular disorders	37
High-throughput proteomics-guided biomarker discovery of hepatocellular carcinoma	37
Bilateral lentiform and caudate nucleus lesions in a child with COVID-19: A case report	37
Editorial Board	35
Editorial Board	35
Macrophages in the male genital tract	33
The effects of macronutrients metabolism on cellular and organismal aging	32
Comprehensive insight into the alterations in the gut microbiome and the intestinal barrier as a consequence of iron deficiency anaemia	31
Clinical and genomic insights into persistent carbapenem-resistant Klebsiella pneumoniae bacteremia: risk factors, resistance mechanisms, and treatment challenges	31
Saliva as a diagnostic tool to measure polycyclic aromatic hydrocarbon exposure in dental patients exposed to intimate partner violence (IPV)	31
Artificial intelligence in infection surveillance: Data integration, applications and future directions	30
Tools to measure membrane potential of neurons	30
Implementation of fecal microbiota transplantation in a medical center for recurrent or refractory Clostridioides difficile infection and report of preliminary outcome	29
The establishment of a molecular diagnostic platform for mitochondrial diseases: From conventional to next-generation sequencing	29
Lifestyle interventions to delay senescence	27

Repeated administration of adipose-derived mesenchymal stem cells added on beneficial effects of empagliflozin on protecting renal function in diabetic kidney disease rat	26
Using time-course as an essential factor to accurately predict sepsis-associated mortality among patients with suspected sepsis	26
Dynamic regulation of RNA m6A methylation in the ribonucleoprotein complexes in apicomplexan and kinetoplastid parasites	26
Editorial Board	26
Discharge status validation of the Chang Gung Research database in Taiwan	26
Additional insights on SARS-CoV-2 spike protein variants and red blood cells biology	26
Advancements, challenges, and future prospects in clinical hyperpolarized magnetic resonance imaging: A comprehensive review	24
Sterile inflammation and the NLRP3 inflammasome in cardiometabolic disease	24
Automatic and human level Graf's type identification for detecting developmental dysplasia of the hip	24
A panel of miRNAs in serum extracellular vesicles serves as novel diagnostic biomarkers for MASLD	23
Caffeic acid phenethyl ester inhibits the growth of bladder carcinoma cells by upregulating growth differentiation factor 15	23
Discrepant treponemal test results: Identification of associated risk factors through machine learning technology in 18-year electronic medical records and national claims data	23
Influence of acupuncture twisting parameters on analgesic effects mediated by mast cells in AA rat models	23
Inhibition of NLRP3 attenuates sodium dextran sulfate-induced inflammatory bowel disease through gut microbiota regulation	23
“Mpox in MSM: Tackling stigma, minimizing risk factors, exploring pathogenesis, and treatment approaches”	22
The binding and specificity of chemokine binding proteins, through the lens of experiment and computation	22
Revisiting the Safety of Short-term Systemic Corticosteroids	21
Circadian rhythmicity and human health	21
Lymphedema imaging and AI: A review of diagnostic modalities, biomarkers, and clinical integration	21
Developmental origins and environmental determinants of cardiovascular–kidney–metabolic syndrome: A pediatric precision prevention perspective	21
Comparing transvenous coiling and transarterial embolization with Onyx/NBCA for cavernous sinus dural arteriovenous fistulas: A retrospective study in a single center	20
Fecal miRNAs as potential biomarkers for early detection of colorectal cancer: An updated review	20
A finger in every pie – The versatility of chemokines	20
Nod-like receptors in inflammatory arthritis	20
Angular super-resolution in X-ray projection radiography using deep neural network: Implementation on rotational angiography	20
Low energy shock wave therapy attenuates mitochondrial dysfunction and improves bladder function in HCl induced cystitis in rats	20
Circ_0011385 knockdown inhibits cell proliferation, migration and invasion, whereas promotes cell apoptosis by regulating miR-330-3p/MYO6 axis in colorectal cancer	20
Effect of three clinical therapies on cytokines modulation in the hip articular cartilage and bone improvement in rat early osteonecrosis of the femoral head	19
Endothelial activation, cell-cell interactions, and inflammatory pathways in postoperative atrial fibrillation following cardiac surgery	19
Systematic analysis of mushroom body-innervating dopaminergic neuron activity in different physiological states in Drosophila	19
Hyperthermic intraperitoneal chemotherapy for recurrent epithelial ovarian cancer	18
Current efforts and challenges facing responses to Monkeypox in United Kingdom	18
Ancient wisdom and modern innovations: Methods of administering healing	18
Multifunctional nanozymes for disease diagnosis and therapy	18
Response to "letter to editor" from Nicolini et al. Regarding "Autonomic modulation and the risk of dementia in a middle-aged cohort: A 17-year follow-up study"	18
Clinical validation of a saliva-based matrix metalloproteinase-1 rapid strip test for detection of oral cavity cancer	17
Inhibition of the 4-hydroxynonenal-regulated JNK/c-Jun pathway improves bleomycin-induced lung fibrosis	17
Extracellular vesicles in fetal-maternal immune tolerance	17
Advancing cancer diagnosis and treatment: Integrating molecular biomarkers and emerging technologies	17
Long non-coding RNAs as modulators of metabolic reprogramming for endogenous heart regeneration: Mechanisms and therapeutic potential	17
Circ_0091579 exerts an oncogenic role in hepatocellular carcinoma via mediating miR-136-5p/TRIM27	17
Acquired Immune Deficiency Syndrome correlation with SARS-CoV-2 N genotypes	17
In vitro axotomy models regulated by ROCK inhibitor for studying neuroregeneration and growth cone morphology	17
Inherently imperfect, inherently evolving – The pursuit of precision through biomarkers	16
SARS-CoV-2 variants – Evolution, spike protein, and vaccines	16
Strides toward a better understanding of the “Current efforts and challenges facing responses to Monkeypox in United Kingdom”	16
CAN008 prolongs overall survival in patients with newly diagnosed GBM characterized by high tumor mutational burden	16
Author reply to letter to the editor “Imaging abnormalities in pediatric neuro-COVID are more diverse than specified”	15
Mitochondrial dysfunction route as a possible biomarker and therapy target for human cancer	15
Chronic low-dose REV-ERBs agonist SR9009 mitigates constant light-induced weight gain and insulin resistance via adipogenesis modulation	15

Macrophages of the heart: Homeostasis and disease	15
The epidemiology of invasive fungal infections in transplant recipients	15
Targeted dexamethasone nano-prodrug for corneal neovascularization management	15
Mouth opening/breathing is common in sleep apnea and linked to more nocturnal water loss	15
Editorial Board	15
Clinical significance of incidental common bile duct dilatation in children: A 10-year single medical center experience	15
Phylogenetic characteristics of Non-SARS human coronavirus in southern Taiwan, 2012–2013	14
Altered diffusivity of the subarachnoid cisterns in the rat brain following neurological disorders	14
Utilizing nomograms to predict prevalent vertebral fracture risk: An analysis of dysmobility syndrome in a community-dwelling population	14
Autophagy-induced osteoblast-derived exosomes maintain bone formation and prevent osteoporosis by remodeling gut microbiota-metabolism	14
Phosphorylated α-synuclein in diluted human serum as a biomarker for Parkinson's disease	14
Biological functions of extracellular vesicles from mammalian cells	13
A comprehensive overview of gastric cancer management from a surgical point of view	13
Editorial Board	13
Evolutionary Conservation, Expansion and Diversification of Interferon stimulated genes (ISG) in Vertebrates: insights from fish	13
Distinct subtypes of kidney transplant-associated urothelial carcinomas harboring BK polyomavirus integration and aristolochic acid mutational signatures	12
Glomerular disease classification and lesion identification by machine learning	12
Prognosis of chronic kidney disease in patients with non-alcoholic fatty liver disease: a Northeastern Taiwan community medicine research cohort	12
Blood oxygenation state in COVID-19 patients: Unexplored role of 2,3-bisphosphoglycerate	12
Editorial Board	12
Factors associated with pyloric hypertrophy severity and post-operative feeding and nutritional recovery in infantile hypertrophic pyloric stenosis	12
Immunosenescence, gut dysbiosis, and chronic kidney disease: Interplay and implications for clinical management	11
COVID-19 vaccination uptake strongly predicts averted deaths of older people across Europe	11
Plasminogen activator Inhibitor-1 in systemic sclerosis: A nexus of fibrosis, vasculopathy, and senescence	11
The 2022 nobel prize in physiology or medicine awarded for the decoding of the complete ancient human genome	11
Curcumin suppresses RANKL-induced osteoclast precursor autophagy in osteoclastogenesis by inhibiting RANK signaling and downstream JNK-BCL2-Beclin1 pathway	11
ShinySC: An R/Shiny-based desktop application for seamless analysis of scRNA-Seq data	11
Genomic surveillance of SARS-CoV-2 in Taiwan: A perspective on evolutionary data interpretation and sequencing issues	11
The clockwork macrophage: Timing in innate immunity	11
Practical applications of grounding to support health	11
Negative regulatory NLRs mitigate inflammation via NF-κB pathway signaling in inflammatory bowel disease	11
LncRNAs and asymmetric cell division: The epigenetic mechanisms	11
BrainView: A cloud-based deep learning system for brain image segmentation, tumor detection and visualization	11
Gut mycobiome in metabolic diseases: Mechanisms and clinical implication	10
Editorial Board	10
The next generation of healthcare ecosystem in the metaverse	10
Kinship analysis of type 2 diabetes mellitus familial aggregation in Taiwan	10
Effects of light, electromagnetic fields and water on biological rhythms	10
Antibody induction in mice by liposome-displayed recombinant enterotoxigenic Escherichia coli (ETEC) colonization antigens	10
Editorial Board	10
A review for cell and particle tracking on microscopy images using algorithms and deep learning technologies	10
Applications of three-dimensional imaging techniques in craniomaxillofacial surgery: A literature review	9
Novel approach by natural language processing for COVID-19 knowledge discovery	9
PAI-1 is a common driver of aging and diverse diseases	9
Deep learning significantly boosts CRT response prediction using synthetic longitudinal strain data: Training on synthetic data and testing on real patients	9
SLC7A11-HSPB1 axis: A novel mechanism for hepatocellular carcinoma progression and ferroptosis regulation	9
c-MYC/METTL3/LINC01006 positive feedback loop promotes migration, invasion and proliferation of non-small cell lung cancer	9
Different impacts of common risk factors associated with thrombocytopenia in patients with hepatitis B virus and hepatitis C virus infection	9
Editorial Board	9
Differential longitudinal effects of frequent sweetened food consumption at different exposure ages on child cognitive, language, and motor development	9
Olesoxime protects against cisplatin-induced acute kidney injury by attenuating mitochondrial dysfunction	9
Small and mighty – microRNAs pulling the strings	9
Editorial Board	9
SARS-CoV-2 pandemics: An update of CRISPR in diagnosis and host–virus interaction studies	8
Apremilast ameliorates acute respiratory distress syndrome by inhibiting neutrophil-induced oxidative stress	8
Role of purinoreceptors in the release of extracellular vesicles and consequences on immune response and cancer progression	8
Basic implications on three pathways associated with SARS-CoV-2	8
Real-world effectiveness of intravitreal dexamethasone implants - Comparison between eyes eligible and ineligible for clinical trials and their associated outcomes	8
Genome-wide association study identifies DRAM1 associated with Tourette syndrome in Taiwan	8
Serum CA-125 and renal impairment in patients undergoing hyperthermic intraperitoneal chemotherapy	8
Glibenclamide attenuates neuronal pyroptosis by modulating KATP channels in the hippocampus of palmitic acid-induced lipotoxic mice	8
Erratum to “Long non-coding RNAs as modulators of metabolic reprogramming for endogenous heart regeneration: Mechanisms and therapeutic potential” [Biomed J 49 (2) (2026) 100914]	8
LncRNA OIP5-AS1 reduces renal epithelial cell apoptosis in cisplatin-induced AKI by regulating the miR-144-5p/PKM2 axis	8
Post-COVID-19 epidemiology of pneumococcal disease in Taiwan: escalating serotype replacement and antimicrobial resistance in all ages	8
The role of blue light-filtering and premium intraocular lenses on postoperative falls: A nationwide target trial emulation in Taiwan	8
An area of greatest vulnerability - Recent advances in kidney injury	8
Mitochondrial bioenergetics deficiency in cisd-1 mutants is linked to AMPK-mediated lipid metabolism	8
Rhythms under tension: Circadian clocks in an Unsynced Society	8
Radium-223 Treatment Outcomes in Patients with Metastatic Castration-Resistant Prostate Cancer: A Taiwan-Japan Collaborative Cohort Study	8
Interferon-alpha and MxA inhibit BK polyomavirus replication by interaction with polyomavirus large T antigen	8
Extracorporeal shockwave therapy ameliorates skin inflammation of imiquimod-induced psoriasis in mice	7
Afterhyperpolarization potential modulated by local [K+]o in K+ diffusion-restricted extracellular space in the central clock of suprachiasmatic nucleus	7
From inhibition to regulation: serpins in health and disease	7
Would foot arch development in children characterize a body maturation process? A prospective longitudinal study	7
Hepatocyte nuclear factor 4 located in different developmental stages of Schistosoma japonicum and involved in important metabolic pathways	7
Mutations in circulating tumor DNA detected in the postoperative period predict poor survival in patients with ovarian cancer	7
Charting new territory: The Plasmodium falciparum tRNA modification landscape	7
Impact of fasting & ketogenic interventions on the NLRP3 inflammasome: A narrative review	7
Using A modified quickert procedure combined with prolapsed fat and preseptal orbicularis muscle removal to correct involutional lower eyelid entropion in Asians	7
Reading the epitranscriptome of the human malaria parasite	7

Cartilage-specific knockout of miRNA-128a expression normalizes the expression of circadian clock genes (CCGs) and mitigates the severity of osteoarthritis	7
The role of gut fungi in Clostridioides difficile infection	6
Correlation of SALL1 with CEUS parameters and immune escape in thyroid carcinoma	6
AIFM1, negatively regulated by miR-145-5p, aggravates hypoxia-induced cardiomyocyte injury	6
MicroRNA-based signature for diagnosis and prognosis of colorectal cancer using residuum of fecal immunochemical test	6
Editorial Board	6
Palatal hybrid surgery for obstructive sleep apnea-state-of-the-art annotation of uvulopalatopharyngoplasty	6
GR/HDAC2/synaptic complexes in hippocampal CA1 mediate the antidepressant effects of magnolol	6
Impact of vertical facial patterns on three-dimensional surgical outcomes and stability in skeletal Class II malocclusion	6
miRNA-mediated regulation of clock gene expression in men and women with colorectal cancer and possible consequences for disease management	6
Phospholipid Diversity and Biosynthesis Pathway in Bacteria: Potential Antibacterial Targets	6
The role of excess charge mitigation in electromagnetic hygiene: An integrative review	6
Elastase reduces background autofluorescence in ALK fluorescence in situ hybridization assays for lung cancers	6
Reply: Serum CA-125 and renal impairment in patients undergoing hyperthermic intraperitoneal chemotherapy	6
A recipe for a good clinical pulmonary surfactant	6
Postnatal intestinal mucosa and gut microbial composition develop hand in hand: A mouse study	6
Effectiveness of BNT162b2 and mRNA-1273 vaccines against COVID-19 omicron variants in children aged 6–11 years in Taiwan	6
Chronobioethics: Symphony of biological clocks observed by 7-day/24-h ambulatory blood pressure monitoring and cardiovascular health	6
The complex interplay between hepatitis D virus and the interferon response	6
Evaluation of clinical relevance and underlying pathology for hemodynamic compromise in acute small subcortical infarction using MRI-based neuroimaging markers	5
Unveiling the mycobiota: The fungal frontier of human health	5
Dynamic monitoring of kidney injury status over 3 days in the intensive care unit as a sepsis phenotype associated with hospital mortality and hyperinflammation	5
Clinical and laboratory predictors for disease progression in patients with COVID-19: A multi-center cohort study	5
Integrating comprehensive genomic profiling in the management of oncology patients: Applications and challenges in Taiwan	5
Acupressure reduces the severity of restless legs syndrome in hemodialysis patients: A cluster-randomized crossover pilot study	5
He protec but he also attac – Inflammasomes swinging the sword	5
Prevention and treatment of COVID-19 infection by earthing	5
IRE1α-mediated endoplasmic reticulum stress response regulates oxidative damage in CYP4V2 deficient human retinal pigment epithelial cells	5
Minimal invasive fixation following with radiotherapy for radiosensitive unstable metastatic spine	5
LAMA5: A new pathogenic gene for non-syndromic cleft lip with or without cleft palate	5
High-fat diet-induced increase in glucocorticoids contributes to adipogenesis in obese mice	5
Evaluation of recurrence risk in patients with papillary thyroid cancer through tumor-node-metastasis staging: A single-center observational study in Taiwan	5
A newly designed flexible hydrated-hardening bone graft (FHBG) promotes bone regeneration and in vivo calvarial repair	5
Effects of Rosa damascena on reproductive improvement, metabolic parameters, liver function and insulin-like growth factor-1 gene expression in estradiol valerate induced polycystic ovarian syndrome i	5
Neuropeptide FF receptor 2 overexpression aggravates lipid accumulation and metabolic dysfunction in mice with diet-induced metabolic stress	5
Regenerative medicine for male infertility: A focus on stem cell niche injury models	5
Secreted proteins encoded by super enhancer-driven genes could be promising biomarkers for early detection of esophageal squamous cell carcinoma	5
Cellular senescence as a therapeutic target for aging intervention	5
Moderate exercise mobilizes Prg4+ cells in the superficial zone of articular cartilage and maintains cartilage homeostasis	5
Msi2 enhances muscle dysfunction in a myotonic dystrophy type 1 mouse model	4
Y-chromosome genes associated with sertoli cell-only syndrome identified by array comparative genome hybridization	4
Immunogenicity of second booster-dose COVID-19 mRNA vaccine among older adults in Taiwan	4
Protein network analysis and functional enrichment via computational biotechnology unravel molecular and pathogenic mechanisms of kidney stone disease	4
Multi-omics insights into uric acid metabolism: from genetics to epigenetics, transcriptomics, and metabolomics in cardiometabolic disease	4
Short-term and long-term psychological impact and quality of life of patients undergoing orthognathic surgery	4
Significance of PAI-1 on the development of skin cancer: Optimal targets for cancer therapies	4
The effect and mechanism of astragalus polysaccharides on T cells and macrophages in inhibiting prostate cancer	4
Influence of electromagnetic fields on the circadian rhythm: Implications for human health and disease	4
Study of polymethylmethacrylate/tricalcium silicate composite cement for orthopedic application	4
Long noncoding RNA TUG1 promotes malignant progression of osteosarcoma by enhancing ZBTB7C expression	4
Editorial Board	4
Cytidine deaminase enhances liver cancer invasion by modulating epithelial-mesenchymal transition via NFκB signaling	4
Mpox: A narrative review on current knowledge	4
Long non-coding RNA TTTY15 sponges miR-520a-3p to exacerbate neural apoptosis induced by cerebral ischemia/reperfusion via targeting IRF9 both in vivo and in vitro	4
Senescence: No country for old cells	4
Associations with lip cant and facial midline correction following bimaxillary surgery in class III asymmetry: A CBCT-based analysis	4
External validation of MAGIC-D model in Taiwanese patients with advanced biliary tract cancer receiving durvalumab and chemotherapy	4
Circadian disruption of feeding-fasting rhythm and its consequences for metabolic, immune, cancer, and cognitive processes	4
Application of extended reality in pediatric neurosurgery: A comprehensive review	4
Altered purinergic P2X7 and A2B receptors signaling limits macrophage-mediated host defense in schistosomiasis	4
Vomocytosis of Cryptococcus neoformans from Macrophages: from discovery to current understanding	4
Increased risk of migraine among patients with hidradenitis suppurativa: A US multi-center cohort study	4
The ratio of remaining to expected small bowel length predicts enteral autonomy in pediatric patients with short bowel syndrome	4
Combined therapy with dapagliflozin and entresto offers an additional benefit on improving the heart function in rat after ischemia-reperfusion injury	4
ECG-surv: A deep learning-based model to predict time to 1-year mortality from 12-lead electrocardiogram	4
Clearing the fog, but not the entire picture: Elastase pretreatment for ALK FISH in lung cancer	4
Fibroblast growth factor 21 and bone homeostasis	4
The synergy of 177Lu-FAPI-46 with tyrosine kinase inhibitor in a sarcoma patient-derived xenograft mouse model	4
Editorial Board	4
A concerted effort combating hepatitis	4
Gut microbiota and clinical response to immune checkpoint inhibitor therapy in patients with advanced cancer	4