OOIR: Observatory of International Research

Papers

(The H4-Index of Frontiers in Molecular Biosciences is 54. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
Is It Time to Start Transitioning From 2D to 3D Cell Culture?	797
Nanoparticle-Based Drug Delivery in Cancer Therapy and Its Role in Overcoming Drug Resistance	487
Immune Phenotyping Based on the Neutrophil-to-Lymphocyte Ratio and IgG Level Predicts Disease Severity and Outcome for Patients With COVID-19	305
Structural Biology in the Clouds: The WeNMR-EOSC Ecosystem	296
Solid Lipid Nanoparticles for Drug Delivery: Pharmacological and Biopharmaceutical Aspects	261
Nanoparticle Surface Functionalization: How to Improve Biocompatibility and Cellular Internalization	210
Role of Copper on Mitochondrial Function and Metabolism	176
Selective Targeting of Cancer Cells by Copper Ionophores: An Overview	175
Structural Characterization of SARS-CoV-2: Where We Are, and Where We Need to Be	151
Circulating Exosomes Are Strongly Involved in SARS-CoV-2 Infection	136
Mismatch Repair Pathway, Genome Stability and Cancer	134
Interactions by Disorder – A Matter of Context	124
Molecular Mechanisms of Adipogenesis: The Anti-adipogenic Role of AMP-Activated Protein Kinase	116
ZEB1: A Critical Regulator of Cell Plasticity, DNA Damage Response, and Therapy Resistance	109
Antibodies and Vaccines Target RBD of SARS-CoV-2	102
Cancer Stem Cell Plasticity – A Deadly Deal	101
Triple-Negative Breast Cancer: A Brief Review About Epidemiology, Risk Factors, Signaling Pathways, Treatment and Role of Artificial Intelligence	100
Application of Fragment-Based Drug Discovery to Versatile Targets	94
In silico Screening of Natural Compounds as Potential Inhibitors of SARS-CoV-2 Main Protease and Spike RBD: Targets for COVID-19	91
Oxidative Stress in Bacteria and the Central Dogma of Molecular Biology	90
Macrophage Plasticity and Atherosclerosis Therapy	84
The Smad Dependent TGF-β and BMP Signaling Pathway in Bone Remodeling and Therapies	84
Differential Wound Healing Capacity of Mesenchymal Stem Cell-Derived Exosomes Originated From Bone Marrow, Adipose Tissue and Umbilical Cord Under Serum- and Xeno-Free Condition	83
Current Opinion on Molecular Characterization for GBM Classification in Guiding Clinical Diagnosis, Prognosis, and Therapy	82
Spike Proteins of SARS-CoV and SARS-CoV-2 Utilize Different Mechanisms to Bind With Human ACE2	79

Virus Detection: A Review of the Current and Emerging Molecular and Immunological Methods	78
Drug Resistance in Glioblastoma: The Two Faces of Oxidative Stress	78
Insights into Aldehyde Dehydrogenase Enzymes: A Structural Perspective	77
ACE2 in the Era of SARS-CoV-2: Controversies and Novel Perspectives	76
Recent Progress in the Drug Development Targeting SARS-CoV-2 Main Protease as Treatment for COVID-19	76
Hsp60 Post-translational Modifications: Functional and Pathological Consequences	74
Drug Repurposing Strategy (DRS): Emerging Approach to Identify Potential Therapeutics for Treatment of Novel Coronavirus Infection	71
Current Strategies of Antiviral Drug Discovery for COVID-19	71
The TRAIL in the Treatment of Human Cancer: An Update on Clinical Trials	70
New Insights Into the Role of Phenotypic Plasticity and EMT in Driving Cancer Progression	67
Current State of Target Treatment in BRAF Mutated Melanoma	67
Glycans of SARS-CoV-2 Spike Protein in Virus Infection and Antibody Production	66
Glycosaminoglycan-Protein Interactions and Their Roles in Human Disease	65
Update in Laboratory Diagnosis of Thalassemia	65
Triazoles and Their Derivatives: Chemistry, Synthesis, and Therapeutic Applications	65
Next Generation Methods for Single-Molecule Force Spectroscopy on Polyproteins and Receptor-Ligand Complexes	63
Anticancer Compounds Based on Isatin-Derivatives: Strategies to Ameliorate Selectivity and Efficiency	63
RNA-Binding Proteins Driving the Regulatory Activity of Small Non-coding RNAs in Bacteria	61
Tumor Microenvironment-Stimuli Responsive Nanoparticles for Anticancer Therapy	60
The Impact of Oxidative Stress in Male Infertility	59
Role of Interleukin-6 in Vascular Health and Disease	58
Recent Advances in Repurposing Disulfiram and Disulfiram Derivatives as Copper-Dependent Anticancer Agents	58
HER2 Low, Ultra-low, and Novel Complementary Biomarkers: Expanding the Spectrum of HER2 Positivity in Breast Cancer	58
Recent Developments in Free Energy Calculations for Drug Discovery	57
Therapeutic Peptides Targeting PPI in Clinical Development: Overview, Mechanism of Action and Perspectives	57
A Comprehensive Analysis of the Role of hnRNP A1 Function and Dysfunction in the Pathogenesis of Neurodegenerative Disease	56
The Functions of BET Proteins in Gene Transcription of Biology and Diseases	55
Evaluation and Comparison of Serological Methods for COVID-19 Diagnosis	55
Butyrate Suppresses Glucose Metabolism of Colorectal Cancer Cells via GPR109a-AKT Signaling Pathway and Enhances Chemotherapy	54