OOIR: Observatory of International Research

Papers

(The H4-Index of Frontiers in Molecular Biosciences is 52. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Implementation of a combined bioinformatics and experimental approach to address lncRNA mechanism of action: The example of NRIR	283
Machine learning-enhanced insights into sphingolipid-based prognostication: revealing the immunological landscape and predictive proficiency for immunomotherapy and chemotherapy responses in pancreati	278
Identification of diagnostic hub genes related to energy metabolism in idiopathic pulmonary fibrosis	215
Editorial: In celebration of women in science: RNA networks and biology	169
Revealing the pharmacological effect and mechanism of darutoside on gouty arthritis by liquid chromatography/mass spectrometry and metabolomics	134
Corrigendum: Evaluation of PIK3CA mutations in advanced ER+/HER2-breast cancer in Portugal – U-PIK Project	134
Biochemical and Structural Characterization of Thermostable GH159 Glycoside Hydrolases Exhibiting α-L-Arabinofuranosidase Activity	127
Corrigendum: RUNX1 Upregulates CENPE to Promote Leukemic Cell Proliferation	125
A Conserved Mitochondrial Chaperone-Protease Complex Involved in Protein Homeostasis	122
Metabolome combined with gut microbiome revealed the lipid-lowering mechanism of Xuezhiping capsule on hyperlipidemic hamster induced by high fat diet	118
Jianpi Yangzheng Xiaozheng granule induced ferroptosis to suppress gastric cancer progression through reprogramming lipid metabolism via SCD1/Wnt/β-catenin axis	113
Editorial: Novel approaches aiming to overcome current nanomedicine limitations	107
Pan-Cancer Analysis and Validation Reveals that D-Dimer-Related Genes are Prognostic and Downregulate CD8+ T Cells via TGF-Beta Signaling in Gastric Cancer	105
Loss of filamentous actin, tight junction protein expression, and paracellular barrier integrity in frataxin-deficient human brain microvascular endothelial cells—implications for blood-brain barrier	105
Identification of Crucial Hub Genes and Differential T Cell Infiltration in Idiopathic Pulmonary Arterial Hypertension Using Bioinformatics Strategies	98
Potential Molecular Targets of Tenofovir Disoproxil Fumarate for Alleviating Chronic Liver Diseases via a Non-Antiviral Effect in a Normal Mouse Model	97
Bioinformatics-Guided Analysis Uncovers AOX1 as an Osteogenic Differentiation-Relevant Gene of Human Mesenchymal Stem Cells	97
Large-Scale Gastric Cancer Susceptibility Gene Identification Based on Gradient Boosting Decision Tree	92
Deepening insights into cholinergic agents for intraocular pressure reduction: systems genetics, molecular modeling, and in vivo perspectives	90
Editorial: Analytical devices based on immobilized macromolecules for structural and activity/affinity studies in drug discovery	90
Integrating network analysis with differential expression to uncover therapeutic and prognostic biomarkers in esophageal squamous cell carcinoma	89
Computational Insights Into the Effects of the R190K and N121Q Mutations on the SARS-CoV-2 Spike Complex With Biliverdin	87
Type-2 diabetes epigenetic biomarkers: present status and future directions for global and Indigenous health	82
ceRNAshiny: An Interactive R/Shiny App for Identification and Analysis of ceRNA Regulation	77
Curcumin-mediated transcriptional regulation of human N-acetylgalactosamine-α2,6-sialyltransferase which synthesizes sialyl-Tn antigen in HCT116 human colon cancer cells	77

Study on the metabolic effects of hexavalent chromium [Cr (VI)] on rat astrocytes using un-targeted metabolomics	75
Investigating potential targets of Wulingsan in diabetic nephropathy through network pharmacology and experimental validation	70
Shared pathobiology identifies AMPK as a therapeutic target for obesity and autosomal dominant polycystic kidney disease	68
Serum Untargeted Metabolomics Reveal Potential Biomarkers of Progression of Diabetic Retinopathy in Asians	66
Crystalline Sponge Method by Three-Dimensional Electron Diffraction	66
RNA sequencing-based profiling of differentially expressed microRNAs in endothelial cells from offspring of hypertensive pregnancies: a preliminary study	65
Production and characterization of monoclonal antibodies for the detection of the hepatitis C core antigen	65
Application of PCR-based approaches for evaluation of cell-free DNA fragmentation in colorectal cancer	65
Identification of key genes related to growth of largemouth bass (Micropterus salmoides) based on comprehensive transcriptome analysis	64
The chemistry of gut microbiome-derived lipopolysaccharides impacts on the occurrence of food allergy in the pediatric age	63
N-3 Polyunsaturated Fatty Acid Dehydrogenase Fat-1 Regulates Mitochondrial Energy Metabolism by Altering DNA Methylation in Isolated Cells of Transgenic Cattle	63
Drugging Fuzzy Complexes in Transcription	63
ER exit in physiology and disease	62
Zinc phthalocyanine loaded- antibody functionalized nanoparticles enhance photodynamic therapy in monolayer (2-D) and multicellular tumour spheroid (3-D) cell cultures	62
The Role of the Thioredoxin Detoxification System in Cancer Progression and Resistance	61
A novel pyroptosis-regulated gene signature for predicting prognosis and immunotherapy response in hepatocellular carcinoma	61
Identification of novel gene signatures and immune cell infiltration in intervertebral disc degeneration using bioinformatics analysis	60
Preparation of RNAs with non-canonical 5′ ends using novel di- and trinucleotide reagents for co-transcriptional capping	58
Identification of biomarkers and immune microenvironment associated with pterygium through bioinformatics and machine learning	58
Modeling of pneumococcal serogroup 10 capsular polysaccharide molecular conformations provides insight into epitopes and observed cross-reactivity	57
Mechanosensory encoding dysfunction emerges from cancer-chemotherapy interaction	57
ELOVL5 and IGFBP6 genes modulate sensitivity of breast cancer cells to ferroptosis	55
Opto-APC: Engineering of cells that display phytochrome B on their surface for optogenetic studies of cell-cell interactions	55
Development of Molecular Mechanisms and Their Application on Oncolytic Newcastle Disease Virus in Cancer Therapy	54
Current research on fungi in chronic wounds	53
Transcriptome Sequencing Reveals Key Genes in Three Early Phases of Osteogenic, Adipogenic, and Chondrogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in Rats	52
The Many Faces of G Protein-Coupled Receptor 143, an Atypical Intracellular Receptor	52
Moving HER2-low breast cancer predictive and prognostic data from clinical trials into the real world	52