OOIR: Observatory of International Research

Papers

(The H4-Index of Frontiers in Molecular Biosciences is 52. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Implementation of a combined bioinformatics and experimental approach to address lncRNA mechanism of action: The example of NRIR	299
Machine learning-enhanced insights into sphingolipid-based prognostication: revealing the immunological landscape and predictive proficiency for immunomotherapy and chemotherapy responses in pancreati	291
Editorial: In celebration of women in science: RNA networks and biology	224
Corrigendum: Evaluation of PIK3CA mutations in advanced ER+/HER2-breast cancer in Portugal – U-PIK Project	185
Revealing the pharmacological effect and mechanism of darutoside on gouty arthritis by liquid chromatography/mass spectrometry and metabolomics	149
Corrigendum: RUNX1 Upregulates CENPE to Promote Leukemic Cell Proliferation	147
Metabolome combined with gut microbiome revealed the lipid-lowering mechanism of Xuezhiping capsule on hyperlipidemic hamster induced by high fat diet	141
Editorial: Novel approaches aiming to overcome current nanomedicine limitations	133
Loss of filamentous actin, tight junction protein expression, and paracellular barrier integrity in frataxin-deficient human brain microvascular endothelial cells—implications for blood-brain barrier	129
Pan-Cancer Analysis and Validation Reveals that D-Dimer-Related Genes are Prognostic and Downregulate CD8+ T Cells via TGF-Beta Signaling in Gastric Cancer	115
Identification of Crucial Hub Genes and Differential T Cell Infiltration in Idiopathic Pulmonary Arterial Hypertension Using Bioinformatics Strategies	113
Large-Scale Gastric Cancer Susceptibility Gene Identification Based on Gradient Boosting Decision Tree	110
Editorial: Analytical devices based on immobilized macromolecules for structural and activity/affinity studies in drug discovery	109
Deepening insights into cholinergic agents for intraocular pressure reduction: systems genetics, molecular modeling, and in vivo perspectives	108
Integrating network analysis with differential expression to uncover therapeutic and prognostic biomarkers in esophageal squamous cell carcinoma	104
Type-2 diabetes epigenetic biomarkers: present status and future directions for global and Indigenous health	98
ceRNAshiny: An Interactive R/Shiny App for Identification and Analysis of ceRNA Regulation	97
Investigating potential targets of Wulingsan in diabetic nephropathy through network pharmacology and experimental validation	94
Shared pathobiology identifies AMPK as a therapeutic target for obesity and autosomal dominant polycystic kidney disease	94
From in vitro to in silico: a pipeline for generating virtual tissue simulations from real image data	93
RNA sequencing-based profiling of differentially expressed microRNAs in endothelial cells from offspring of hypertensive pregnancies: a preliminary study	92
Transcriptome Sequencing Reveals Key Genes in Three Early Phases of Osteogenic, Adipogenic, and Chondrogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in Rats	85
Preparation of RNAs with non-canonical 5′ ends using novel di- and trinucleotide reagents for co-transcriptional capping	85
Carbon Dioxide and the Carbamate Post-Translational Modification	81
Editorial: The Dual-Use Dilemma for Biomimicry	75

Editorial: Interactions of nanoparticles with and within living organisms—What can we learn to improve efficacy of nanomedicine?	74
Melasolv™: a potential preventive and depigmenting agent for the senescence of melanocytes	73
Cardiolipin occupancy profiles of YidC paralogs reveal the significance of respective TM2 helix residues in determining paralog-specific phenotypes	71
Untargeted Metabolomics Studies of H9c2 Cardiac Cells Submitted to Oxidative Stress, β-Adrenergic Stimulation and Doxorubicin Treatment: Investigation of Cardiac Biomarkers	70
Production and characterization of monoclonal antibodies for the detection of the hepatitis C core antigen	69
Biochemical and Structural Characterization of Thermostable GH159 Glycoside Hydrolases Exhibiting α-L-Arabinofuranosidase Activity	69
Opto-APC: Engineering of cells that display phytochrome B on their surface for optogenetic studies of cell-cell interactions	68
The application of exosomes in the treatment of triple-negative breast cancer	68
The endothelial layer formation in the presence of AuNPs/CdSe/TaNPs-loaded PLCL/PVP-based electrospun nanofibers	67
Editorial: Ironome: a still untapped frontier	67
Two-Metal-Ion Catalysis: Inhibition of DNA Polymerase Activity by a Third Divalent Metal Ion	65
Autosomal dominant and autosomal recessive polycystic kidney disease: hypertension and secondary cardiovascular effect in children	64
Modeling of pneumococcal serogroup 10 capsular polysaccharide molecular conformations provides insight into epitopes and observed cross-reactivity	63
ER exit in physiology and disease	60
Application of PCR-based approaches for evaluation of cell-free DNA fragmentation in colorectal cancer	60
N-3 Polyunsaturated Fatty Acid Dehydrogenase Fat-1 Regulates Mitochondrial Energy Metabolism by Altering DNA Methylation in Isolated Cells of Transgenic Cattle	60
Identification of diagnostic hub genes related to energy metabolism in idiopathic pulmonary fibrosis	59
Identification of key genes related to growth of largemouth bass (Micropterus salmoides) based on comprehensive transcriptome analysis	59
Sex-dependent alterations of salivary microbiome in Parkinson’s disease: associations with motor and non-motor clinical phenotypes	58
Enhanced enrichment of extracellular vesicles for laboratory and clinical research from drop-sized blood samples	58
Zinc phthalocyanine loaded- antibody functionalized nanoparticles enhance photodynamic therapy in monolayer (2-D) and multicellular tumour spheroid (3-D) cell cultures	58
Bioactive chemical composition and pharmacological insights into Salvia species	56
The chemistry of gut microbiome-derived lipopolysaccharides impacts on the occurrence of food allergy in the pediatric age	55
Crystalline Sponge Method by Three-Dimensional Electron Diffraction	55
ELOVL5 and IGFBP6 genes modulate sensitivity of breast cancer cells to ferroptosis	54
Technical Validation and Clinical Utility of an NGS Targeted Panel to Improve Molecular Characterization of Pediatric Acute Leukemia	53
Identification of biomarkers and immune microenvironment associated with pterygium through bioinformatics and machine learning	52
Ranolazine Inhibits Pyroptosis via Regulation of miR-135b in the Treatment of Diabetic Cardiac Fibrosis	52