Frontiers in Cell and Developmental Biology

(The TQCC of Frontiers in Cell and Developmental Biology is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)
Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype611
Iron Metabolism in Ferroptosis403
PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor Resistance305
Mitophagy, Mitochondrial Homeostasis, and Cell Fate294
Oxidative Damage and Antioxidant Defense in Ferroptosis257
Beneficial and Detrimental Effects of Reactive Oxygen Species on Lifespan: A Comprehensive Review of Comparative and Experimental Studies208
Resistance Mechanisms of Anti-PD1/PDL1 Therapy in Solid Tumors200
Characteristics and Biomarkers of Ferroptosis197
MicroRNAs: From Mechanism to Organism192
Metabolism of Amino Acids in Cancer178
The Keloid Disorder: Heterogeneity, Histopathology, Mechanisms and Models150
In vitro Models of Neurodegenerative Diseases145
The Balance of TNF Mediated Pathways Regulates Inflammatory Cell Death Signaling in Healthy and Diseased Tissues144
Senescence in Mesenchymal Stem Cells: Functional Alterations, Molecular Mechanisms, and Rejuvenation Strategies142
TGF-β-Induced Endothelial to Mesenchymal Transition in Disease and Tissue Engineering135
Molecular Bases of VEGFR-2-Mediated Physiological Function and Pathological Role133
The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy132
The Emerging Role of the Mammalian Glycocalyx in Functional Membrane Organization and Immune System Regulation127
Selective Targeting of TNF Receptors as a Novel Therapeutic Approach126
On-Target Anti-TGF-β Therapies Are Not Succeeding in Clinical Cancer Treatments: What Are Remaining Challenges?124
The Pyroptosis-Related Signature Predicts Prognosis and Indicates Immune Microenvironment Infiltration in Gastric Cancer122
Comparative Analysis of BTK Inhibitors and Mechanisms Underlying Adverse Effects121
The mTOR–Autophagy Axis and the Control of Metabolism119
Interplay Between Lipid Metabolism and Autophagy112
Immunomodulatory Effect of Adipose-Derived Stem Cells: The Cutting Edge of Clinical Application112
N6-Methylandenosine-Related lncRNAs Are Potential Biomarkers for Predicting the Overall Survival of Lower-Grade Glioma Patients111
Premature Ovarian Insufficiency: Past, Present, and Future109
The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines105
Cathepsin K: The Action in and Beyond Bone105
Exosomes, a New Star for Targeted Delivery105
Mechanoregulation of YAP and TAZ in Cellular Homeostasis and Disease Progression105
Endometrial and Menstrual Blood Mesenchymal Stem/Stromal Cells: Biological Properties and Clinical Application105
Targeting Rho GTPase Signaling Networks in Cancer103
The Role of Exosomes and Exosomal MicroRNA in Cardiovascular Disease102
Recent Advances of Osterix Transcription Factor in Osteoblast Differentiation and Bone Formation102
Laboratory Testing Methods for Novel Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2)102
Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma: Origin, Polarization, Function, and Reprogramming101
The Mechanics of Mitotic Cell Rounding99
Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression99
Role of Epithelial-Mesenchymal Transition in Retinal Pigment Epithelium Dysfunction97
Liver Fibrosis: Therapeutic Targets and Advances in Drug Therapy97
Tumor Endothelial Cells (TECs) as Potential Immune Directors of the Tumor Microenvironment – New Findings and Future Perspectives97
Tumor Microenvironment in Ovarian Cancer: Function and Therapeutic Strategy96
The Ageing Brain: Molecular and Cellular Basis of Neurodegeneration95
BMSC-Derived Exosomal miR-29a Promotes Angiogenesis and Osteogenesis94
Bearing My Heart: The Role of Extracellular Matrix on Cardiac Development, Homeostasis, and Injury Response92
The Role of Autophagy in Osteoarthritis91
GAP-43 and BASP1 in Axon Regeneration: Implications for the Treatment of Neurodegenerative Diseases90
The Inhibitory Effect of Curcumin on Virus-Induced Cytokine Storm and Its Potential Use in the Associated Severe Pneumonia90
Molecular Mechanisms of Cardiomyocyte Death in Drug-Induced Cardiotoxicity89
Physiological Signaling Functions of Reactive Oxygen Species in Stem Cells: From Flies to Man89
Structural and Functional Dysbiosis of Fecal Microbiota in Chinese Patients With Alzheimer's Disease89
Hepatic Stellate Cells and Hepatocarcinogenesis87
Targeting Cell Death: Pyroptosis, Ferroptosis, Apoptosis and Necroptosis in Osteoarthritis87
Roles of Macrophages in the Development and Treatment of Gut Inflammation86
Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds86
The Extracellular Matrix in Skin Inflammation and Infection86
Epigenetics of Male Infertility: The Role of DNA Methylation86
Single-Cell RNA-seq Identifies Cell Subsets in Human Placenta That Highly Expresses Factors Driving Pathogenesis of SARS-CoV-286
Regulatory Mechanisms of Vitellogenesis in Insects85
Biological Function of Long Non-coding RNA (LncRNA) Xist85
Notch Signaling in Vascular Endothelial Cells, Angiogenesis, and Tumor Progression: An Update and Prospective85
Nicotinamide Mononucleotide: A Promising Molecule for Therapy of Diverse Diseases by Targeting NAD+ Metabolism84
New Insights of Emerging SARS-CoV-2: Epidemiology, Etiology, Clinical Features, Clinical Treatment, and Prevention84
Cancer-Associated Fibroblast (CAF) Heterogeneity and Targeting Therapy of CAFs in Pancreatic Cancer83
Selective Autophagy Receptor p62/SQSTM1, a Pivotal Player in Stress and Aging83
The Epithelial-to-Mesenchymal Transition as a Possible Therapeutic Target in Fibrotic Disorders82
Deciphering Epitranscriptome: Modification of mRNA Bases Provides a New Perspective for Post-transcriptional Regulation of Gene Expression82
MitophAging: Mitophagy in Aging and Disease82
Mitochondrial Transfer and Regulators of Mesenchymal Stromal Cell Function and Therapeutic Efficacy81
Recent Trends in the Development of Bone Regenerative Biomaterials80
Horizontal Gene Transfer: From Evolutionary Flexibility to Disease Progression80
The Role of Notch, Hedgehog, and Wnt Signaling Pathways in the Resistance of Tumors to Anticancer Therapies80
Mitochondrial Dynamics: Fission and Fusion in Fate Determination of Mesenchymal Stem Cells80
Mesenchymal Stem Cell Senescence and Rejuvenation: Current Status and Challenges79
Development and Validation of a Combined Ferroptosis and Immune Prognostic Classifier for Hepatocellular Carcinoma78
Signaling Pathways Involved in Diabetic Renal Fibrosis77
Scalable Production of Human Mesenchymal Stromal Cell-Derived Extracellular Vesicles Under Serum-/Xeno-Free Conditions in a Microcarrier-Based Bioreactor Culture System77
Named Entity Recognition and Relation Detection for Biomedical Information Extraction77
The Why of YY1: Mechanisms of Transcriptional Regulation by Yin Yang 177
Severity Detection for the Coronavirus Disease 2019 (COVID-19) Patients Using a Machine Learning Model Based on the Blood and Urine Tests77
Role of Wnt Signaling in Adult Hippocampal Neurogenesis in Health and Disease77
The “Neuro-Glial-Vascular” Unit: The Role of Glia in Neurovascular Unit Formation and Dysfunction77
Targeting Mitochondrial Impairment in Parkinson's Disease: Challenges and Opportunities77
Macrophage Dysregulation and Impaired Skin Wound Healing in Diabetes76
Mitochondria-Associated ER Membranes – The Origin Site of Autophagy76
The Role of Mitochondrial Dynamics and Mitophagy in Carcinogenesis, Metastasis and Therapy76
Development of Extracellular Vesicle Therapeutics: Challenges, Considerations, and Opportunities75
Immunomodulatory Properties of Mesenchymal Stromal Cells: An Update75
Connective Tissue Growth Factor: From Molecular Understandings to Drug Discovery75
CXCL11 Correlates With Antitumor Immunity and an Improved Prognosis in Colon Cancer75
Epithelial-Mesenchymal Transition and Metabolic Switching in Cancer: Lessons From Somatic Cell Reprogramming74
The Current Status of Mesenchymal Stromal Cells: Controversies, Unresolved Issues and Some Promising Solutions to Improve Their Therapeutic Efficacy74
Long Non-coding RNAs and MicroRNAs Interplay in Osteogenic Differentiation of Mesenchymal Stem Cells72
Characterization of Human Colon Organoids From Inflammatory Bowel Disease Patients72
The Integral Role of RNA in Stress Granule Formation and Function71
ORF3a-Mediated Incomplete Autophagy Facilitates Severe Acute Respiratory Syndrome Coronavirus-2 Replication71
Evaluating DNA Methylation, Gene Expression, Somatic Mutation, and Their Combinations in Inferring Tumor Tissue-of-Origin71
The Therapeutic Potential of Mesenchymal Stromal Cells for Regenerative Medicine: Current Knowledge and Future Understandings71
Transmission Routes Analysis of SARS-CoV-2: A Systematic Review and Case Report71
Tissue-Resident Macrophage Development and Function70
Exosomal miRNA-16-5p Derived From M1 Macrophages Enhances T Cell-Dependent Immune Response by Regulating PD-L1 in Gastric Cancer70
Adipogenesis, Osteogenesis, and Chondrogenesis of Human Mesenchymal Stem/Stromal Cells: A Comparative Transcriptome Approach70
Glucose Metabolism and Glucose Transporters in Breast Cancer70
Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3): Unraveling the Role in Mediating IGF-Independent Effects Within the Cell69
The Neurovascular Unit in Glaucomatous Neurodegeneration69
The Role of Tumor-Stroma Interactions in Drug Resistance Within Tumor Microenvironment69
Brain Neurotransmitter Modulation by Gut Microbiota in Anxiety and Depression68
Role of YAP/TAZ in Cell Lineage Fate Determination and Related Signaling Pathways68
Mitochondria-Associated Endoplasmic Reticulum Membranes in Cardiovascular Diseases68
An Eight-CircRNA Assessment Model for Predicting Biochemical Recurrence in Prostate Cancer68
Pluripotent Stem Cell Therapies for Parkinson Disease: Present Challenges and Future Opportunities67
Therapeutic Use of Mesenchymal Stromal Cells: The Need for Inclusive Characterization Guidelines to Accommodate All Tissue Sources and Species67
Adaptive Mechanisms of Tumor Therapy Resistance Driven by Tumor Microenvironment67
Running Against the Wnt: How Wnt/β-Catenin Suppresses Adipogenesis66
Communications Between Bone Marrow Macrophages and Bone Cells in Bone Remodeling66
The Senolytic Drug Navitoclax (ABT-263) Causes Trabecular Bone Loss and Impaired Osteoprogenitor Function in Aged Mice66
Molecular Aspects and Future Perspectives of Cytokine-Based Anti-cancer Immunotherapy65
Blockade of GCH1/BH4 Axis Activates Ferritinophagy to Mitigate the Resistance of Colorectal Cancer to Erastin-Induced Ferroptosis65
MicroRNA-34a: Potent Tumor Suppressor, Cancer Stem Cell Inhibitor, and Potential Anticancer Therapeutic65
Complement Receptors and Their Role in Leukocyte Recruitment and Phagocytosis65
Regeneration of Functional Neurons After Spinal Cord Injury via in situ NeuroD1-Mediated Astrocyte-to-Neuron Conversion65
The Application of Brain Organoids: From Neuronal Development to Neurological Diseases64
B Cell Orchestration of Anti-tumor Immune Responses: A Matter of Cell Localization and Communication64
Mesenchymal Stromal Cells as Critical Contributors to Tissue Regeneration64
Effect of Nuclear Stiffness on Cell Mechanics and Migration of Human Breast Cancer Cells64
Mutant p53 Gain-of-Function: Role in Cancer Development, Progression, and Therapeutic Approaches64
From Flies to Men: ROS and the NADPH Oxidase in Phagocytes63
Mesenchymal Stromal Cells and Exosomes: Progress and Challenges63
TGF-β Signaling and Resistance to Cancer Therapy63
m6A Regulators Is Differently Expressed and Correlated With Immune Response of Esophageal Cancer62
Exosomes From Adipose-Derived Stem Cells: The Emerging Roles and Applications in Tissue Regeneration of Plastic and Cosmetic Surgery61
Targeting Rac and Cdc42 GEFs in Metastatic Cancer61
The Roles of 2-Hydroxyglutarate61
Role of Cholesterol and Lipid Rafts in Cancer Signaling: A Promising Therapeutic Opportunity?61
LRP5 and LRP6 in Wnt Signaling: Similarity and Divergence61
Bone and Muscle Crosstalk in Aging61
H3K4me1 Distribution Predicts Transcription State and Poising at Promoters61
Guidelines for Regulated Cell Death Assays: A Systematic Summary, A Categorical Comparison, A Prospective60
Multiple Functions of ATG8 Family Proteins in Plant Autophagy60
A Guide to Nucleic Acid Vaccines in the Prevention and Treatment of Infectious Diseases and Cancers: From Basic Principles to Current Applications60
Neuron-Oligodendrocyte Interactions in the Structure and Integrity of Axons59
Thyroid Hormones Interaction With Immune Response, Inflammation and Non-thyroidal Illness Syndrome59
New Insights Into Targeting Membrane Lipids for Cancer Therapy59
Mitochondrial Function and Dysfunction in Dilated Cardiomyopathy59
Ferroptosis in Acute Central Nervous System Injuries: The Future Direction?59
CircRNA Is a Rising Star in Researches of Ocular Diseases59
Primary Cilia, Ciliogenesis and the Actin Cytoskeleton: A Little Less Resorption, A Little More Actin Please59
Cyclin E/CDK2: DNA Replication, Replication Stress and Genomic Instability59
Natural Compounds and Autophagy: Allies Against Neurodegeneration58
Cell-Free DNA: Hope and Potential Application in Cancer58
Ran GTPase: A Key Player in Tumor Progression and Metastasis58
Targeting USP7-Mediated Deubiquitination of MDM2/MDMX-p53 Pathway for Cancer Therapy: Are We There Yet?58
Subchondral Bone Remodeling: A Therapeutic Target for Osteoarthritis58
Targeting Immune Cells in the Tumor Microenvironment of HCC: New Opportunities and Challenges58
Dissecting the Crosstalk Between Nrf2 and NF-κB Response Pathways in Drug-Induced Toxicity57
The Mitochondrial Response to DNA Damage57
Obesity and Bone Health: A Complex Link57
Mechanisms of Oocyte Maturation and Related Epigenetic Regulation57
Emerging Roles of Exosomal Circular RNAs in Cancer56
Modeling Inflammation in Zebrafish for the Development of Anti-inflammatory Drugs56
Identifying Transcriptomic Signatures and Rules for SARS-CoV-2 Infection56
Two Types of Contact Between Lipid Droplets and Mitochondria56
Cancer Stem Cells: Emerging Key Players in Immune Evasion of Cancers56
A Novel Ten-Gene Signature Predicting Prognosis in Hepatocellular Carcinoma56
N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and Applications55
Endothelial-to-Mesenchymal Transition in Cancer55
Prognostic Significance and Tumor Immune Microenvironment Heterogenicity of m5C RNA Methylation Regulators in Triple-Negative Breast Cancer55
Quercetin Suppresses Apoptosis and Attenuates Intervertebral Disc Degeneration via the SIRT1-Autophagy Pathway55
A Critical Perspective on 3D Liver Models for Drug Metabolism and Toxicology Studies55
The Role of Short-Chain Fatty Acids and Bile Acids in Intestinal and Liver Function, Inflammation, and Carcinogenesis55
Cadmium-Induced Cytotoxicity: Effects on Mitochondrial Electron Transport Chain55
New Understanding of the Relevant Role of LINE-1 Retrotransposition in Human Disease and Immune Modulation54
Mesenchymal Stem Cells Adaptively Respond to Environmental Cues Thereby Improving Granulation Tissue Formation and Wound Healing54
Exosomal PD-L1: New Insights Into Tumor Immune Escape Mechanisms and Therapeutic Strategies54
Regulation of V-ATPase Activity and Organelle pH by Phosphatidylinositol Phosphate Lipids54
In vivo Neuroregeneration to Treat Ischemic Stroke Through NeuroD1 AAV-Based Gene Therapy in Adult Non-human Primates54
Insights Into the Role of CircRNAs: Biogenesis, Characterization, Functional, and Clinical Impact in Human Malignancies54
The Role of Gut Microbial β-Glucuronidase in Estrogen Reactivation and Breast Cancer54
Mesenchymal Stem Cell-Macrophage Crosstalk and Maintenance of Inflammatory Microenvironment Homeostasis54
Down-Regulated Exosomal MicroRNA-221 – 3p Derived From Senescent Mesenchymal Stem Cells Impairs Heart Repair54
Mitochondrial Function in Muscle Stem Cell Fates54
Mitochondrial OMA1 and OPA1 as Gatekeepers of Organellar Structure/Function and Cellular Stress Response53
USP7 Is a Master Regulator of Genome Stability53
Liraglutide Alleviates Hepatic Steatosis by Activating the TFEB-Regulated Autophagy-Lysosomal Pathway53
Mitochondrial Dynamics in Adult Cardiomyocytes and Heart Diseases53
Mitochondria Donation by Mesenchymal Stem Cells: Current Understanding and Mitochondria Transplantation Strategies53
The Dimensions of Primary Mitochondrial Disorders53
HGF and MET: From Brain Development to Neurological Disorders52
The MicroRNA Family Gets Wider: The IsomiRs Classification and Role52
Global Research Trends of Ferroptosis: A Rapidly Evolving Field With Enormous Potential52
The Role of ARF Family Proteins and Their Regulators and Effectors in Cancer Progression: A Therapeutic Perspective52
Niches for Skeletal Stem Cells of Mesenchymal Origin52
Is Senescence-Associated β-Galactosidase a Reliable in vivo Marker of Cellular Senescence During Embryonic Development?52
Osteoclast Signal Transduction During Bone Metastasis Formation52
The Nrf2 Pathway in Liver Diseases52
Ion Transport in Eryptosis, the Suicidal Death of Erythrocytes52
COVID-19 and the Vasculature: Current Aspects and Long-Term Consequences52
Development and Validation of a Robust Ferroptosis-Related Prognostic Signature in Lung Adenocarcinoma52
Fusobacterium nucleatum Acts as a Pro-carcinogenic Bacterium in Colorectal Cancer: From Association to Causality51
Telomere Replication: Solving Multiple End Replication Problems51
Citicoline Protects Auditory Hair Cells Against Neomycin-Induced Damage51
Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Lung Diseases: Current Status and Perspectives51
nCOVID-19 Pandemic: From Molecular Pathogenesis to Potential Investigational Therapeutics51
CD226: An Emerging Role in Immunologic Diseases51
The Role of Proteoglycans in Cancer Metastasis and Circulating Tumor Cell Analysis50
A Prognostic Ferroptosis-Related lncRNAs Signature Associated With Immune Landscape and Radiotherapy Response in Glioma50
Expression of m6A Regulators Correlated With Immune Microenvironment Predicts Therapeutic Efficacy and Prognosis in Gliomas50
Genetic Engineering as a Strategy to Improve the Therapeutic Efficacy of Mesenchymal Stem/Stromal Cells in Regenerative Medicine50
Biophysical and Biochemical Cues of Biomaterials Guide Mesenchymal Stem Cell Behaviors50
STING1 Promotes Ferroptosis Through MFN1/2-Dependent Mitochondrial Fusion50
Molecular Crosstalk Between MYC and HIF in Cancer50
Connecting the Dots: Resolving the Bone Marrow Niche Heterogeneity50
Fibroblast Senescence in Idiopathic Pulmonary Fibrosis50
Cardiomyocyte Proliferation and Maturation: Two Sides of the Same Coin for Heart Regeneration50
Roles of N6-Methyladenosine (m6A) in Stem Cell Fate Decisions and Early Embryonic Development in Mammals50
Insights on SARS-CoV-2 Molecular Interactions With the Renin-Angiotensin System49
The Role of Astrocytes in the Neurorepair Process49
The Paradoxical Role of Cellular Senescence in Cancer49
Modeling Rett Syndrome With Human Patient-Specific Forebrain Organoids49
Identification and Validation of Pyroptosis-Related Gene Signature to Predict Prognosis and Reveal Immune Infiltration in Hepatocellular Carcinoma49
When Stiffness Matters: Mechanosensing in Heart Development and Disease49
Extracellular Vesicles Derived From Apoptotic Cells: An Essential Link Between Death and Regeneration48
Comparative Genomics of Peroxisome Biogenesis Proteins: Making Sense of the PEX Proteins48
LncRNA KCNQ1OT1 Secreted by Tumor Cell-Derived Exosomes Mediates Immune Escape in Colorectal Cancer by Regulating PD-L1 Ubiquitination via MiR-30a-5p/USP2248
Inflammation and Wnt Signaling: Target for Immunomodulatory Therapy?48
Identification of CDK2-Related Immune Forecast Model and ceRNA in Lung Adenocarcinoma, a Pan-Cancer Analysis48
Heterochromatin as an Important Driver of Genome Organization48
Mesenchymal Stromal Cell-Produced Components of Extracellular Matrix Potentiate Multipotent Stem Cell Response to Differentiation Stimuli48
Membrane-Interacting Antifungal Peptides48
Nerves in the Tumor Microenvironment: Origin and Effects48
Emerging Roles of Liquid–Liquid Phase Separation in Cancer: From Protein Aggregation to Immune-Associated Signaling47
The Roles of Epigenetics Regulation in Bone Metabolism and Osteoporosis47
Regulation of Myostatin on the Growth and Development of Skeletal Muscle47
Recent Update of HDAC Inhibitors in Lymphoma47
Exosome-Based Delivery of Natural Products in Cancer Therapy47
Molecular Mechanisms of Chondrocyte Proliferation and Differentiation47
Vertebrate Sensory Ganglia: Common and Divergent Features of the Transcriptional Programs Generating Their Functional Specialization47
Reactive Oxygen Species: Not Omnipresent but Important in Many Locations46
Structural Characteristics, Binding Partners and Related Diseases of the Calponin Homology (CH) Domain46
Age-Related Macular Degeneration Revisited: From Pathology and Cellular Stress to Potential Therapies46
Disease Activity-Associated Alteration of mRNA m5 C Methylation in CD4+ T Cells of Systemic Lupus Erythematosus46
Induction of Autophagy by Pterostilbene Contributes to the Prevention of Renal Fibrosis via Attenuating NLRP3 Inflammasome Activation and Epithelial-Mesenchymal Transition46
Integrating the Hallmarks of Aging Throughout the Tree of Life: A Focus on Mitochondrial Dysfunction46
Midbrain Organoids: A New Tool to Investigate Parkinson’s Disease46
MicroRNA-221/222 Mediates ADSC-Exosome-Induced Cardioprotection Against Ischemia/Reperfusion by Targeting PUMA and ETS-145
Neurovascular Coupling in Development and Disease: Focus on Astrocytes45
Premyelinating Oligodendrocytes: Mechanisms Underlying Cell Survival and Integration45
Autophagy, Pyroptosis, and Ferroptosis: New Regulatory Mechanisms for Atherosclerosis45
Non-syndromic Cleft Palate: An Overview on Human Genetic and Environmental Risk Factors45