Frontiers in Cell and Developmental Biology

Article	Citations
Methods for automating the analysis of live-cell single-molecule FRET data	361
Construction of a prognostic assessment model for colon cancer patients based on immune-related genes and exploration of related immune characteristics	160
The orobasal organ (of Ackerknecht) is present in prenatal mice	156
General Commentary: Synovial sarcoma of the head and neck: A review of reported cases on the clinical characteristics and treatment methods	144
Overexpression of long noncoding RNA 4933425B07Rik leads to renal hypoplasia by inactivating Wnt/β-catenin signaling pathway	130
Editorial: The self-renewal and reprogramming of cancer stem cells and their crosstalk with the immune microenvironment	124
Deficiency of mastl, a mitotic regulator, results in cell detachment from developing tissues of zebrafish embryos	120
Editorial: Mechanistic studies of genome integrity, environmental health, and cancer etiology	115
Editorial: Immunological imbalance: What is its role in intervertebral disc degeneration?	108
Editorial: Development, metabolism, senescence and mechanotransduction of bone	103
Chronic electrical stimulation with a peripheral suprachoroidal retinal implant: a preclinical safety study of neuroprotective stimulation	103
SNHG12 downregulation induces follicular dysplasia by modulating the glycolysis of granulosa cell in polycystic ovary syndrome	102
Editorial: DNA damage response in the context of chromatin	99
Editorial: WT1 in Development and Disease	97
Maternal Factor Dppa3 Activates 2C-Like Genes and Depresses DNA Methylation in Mouse Embryonic Stem Cells	97
EdeepSADPr: an extensive deep-learning architecture for prediction of the in situ crosstalks of serine phosphorylation and ADP-ribosylation	96
A novel GCaMP6f-RCS rat model for studying electrical stimulation in the degenerated retina	95
Editorial: Post-transcriptional regulation of embryonic and adult myogenesis	92
Editorial: The contribution of autophagy to neuronal metabolism	89
Linoleic acid metabolite 13-Hydroxyoctadecadienoic acid as a biphasic ferroptosis modulator in granulosa cells: multi-omics analysis of ovine atretic follicles	88
Targeting N-type calcium channels in young-onset of some neurological diseases	87
Transcriptomic analysis of mammary gland tissues in lactating and non-lactating dairy goats reveals miRNA-mediated regulation of lactation, involution, and remodeling	87
A missense mutation in Ehd1 associated with defective spermatogenesis and male infertility	86
Regulation of the microprocessor by post-translational modifications	86
Real-world database evaluation of drug-associated vitreous opacities and machine learning for clinical interpretability	84

Generation and functional characterization of tuft cells in non-human primate pancreatic ducts through organoid culture systems	83
Integrative analysis of EMT-driving genes identifies a prognostic signature and GJB2 as a potential biomarker in glioblastoma	83
CausalFormer-HMC: a hybrid memory-driven transformer with causal reasoning and counterfactual explainability for leukemia diagnosis	83
Amniotic mesenchymal stem cells attenuate diabetic cardiomyopathy by inhibiting pyroptosis via modulation of the TLR4/NF-κb/NLRP3 pathway	83
TRPV1 channel in spermatozoa is a molecular target for ROS-mediated sperm dysfunction and differentially expressed in both natural and ART pregnancy failure	82
Emerging Roles of Long Noncoding RNAs in Breast Cancer Epigenetics and Epitranscriptomics	82
Shank3 related muscular hypotonia is accompanied by increased intracellular calcium concentrations and ion channel dysregulation in striated muscle tissue	78
Fertility preservation in male cancer patients. Counseling and reproductive outcomes	78
Quaking but not parkin is the major tumor suppressor in 6q deleted region in glioblastoma	77
PARP9 drives the malignant progression of pancreatic cancer cells by regulating apoptosis, DNA damage, and multidrug efflux systems	75
Effectiveness comparison of pembrolizumab versus other immune checkpoint inhibitors in neoadjuvant chemoimmunotherapy for esophageal squamous cell carcinoma	74
Genome-Wide DNA Methylation Profiling in CD8 T-Cells and Gamma Delta T-Cells of Asian Indian Patients With Takayasu Arteritis	74
Decoding RNF20: an epigenetic modifier and beyond	73
Metabolic biomarkers of neonatal sepsis: identification using metabolomics combined with machine learning	73
Selective vulnerability of human-induced pluripotent stem cells to dihydroorotate dehydrogenase inhibition during mesenchymal stem/stromal cell purification	72
Characterization of mesenchymal stem cells in pre-B acute lymphoblastic leukemia	72
ERK5 Signalling and Resistance to ERK1/2 Pathway Therapeutics: The Path Less Travelled?	72
GFAP serves as a structural element of tunneling nanotubes between glioblastoma cells and could play a role in the intercellular transfer of mitochondria	72
Multimodal reasoning agent for enhanced ophthalmic decision-making: a preliminary real-world clinical validation	72
Retraction: MiR-221/222 ameliorates deoxynivalenol-induced apoptosis and proliferation inhibition in intestinal epithelial cells by targeting PTEN	71
Integrated proteome sequencing, bulk RNA sequencing and single-cell RNA sequencing to identify potential biomarkers in different grades of intervertebral disc degeneration	71
The diverse roles of macrophages in metabolic inflammation and its resolution	70
Granulosa Cells Improved Mare Oocyte Cytoplasmic Maturation by Providing Collagens	68
Mitoregulin, a tiny protein at the crossroads of mitochondrial functioning, stress, and disease	68
The regulation of transcription elongation in embryonic stem cells	68
Obesity and sudden cardiac death: Prevalence, pathogenesis, prevention and intervention	68
Midline 1 associated with Fas signaling enhances murine antigen-induced arthritis	68
Editorial: Ethological dynamics in diorama environments	67
The role of ANLN in malignant tumors: pathogenesis, treatment resistance and targeted strategies	67
Correction: ELOVL2 mediated stabilization of AR contributes to enzalutamide resistance in prostate cancer	67
Corrigendum: The highly and perpetually upregulated thyroglobulin gene is a hallmark of functional thyrocytes	67
Corrigendum: Single-cell RNA sequencing reveals the role of phosphorylation-related genes in hepatocellular carcinoma stem cells	64
Krill oil treatment ameliorates lipid metabolism imbalance in chronic unpredicted mild stress-induced depression-like behavior in mice	63
Corrigendum: Global research trends of ferroptosis: a rapidly evolving field with enormous potential	63
Activation of telomerase via madecassic acid enhances the developmental competence of the SCNT-derived bovine embryos	62
DNA repair genes play a variety of roles in the development of fish embryos	62
New strategies for neuro protection in glaucoma	62
Ferroptosis and Alzheimer’s disease: unraveling the molecular mechanisms and therapeutic opportunities	62
Editorial: Biophysical target engagement assays in chemical biology and pharmacological research	62
Integrated genomic analysis identifies novel low-frequency cis-regulatory variant rs2279658 associated with VSD risk in Chinese children	61
Treatment of patients with metastatic epidural spinal cord compression using an enhanced recovery after surgery program	60
Role of UDP-glucose ceramide glucosyltransferase in venous malformation	60
Coupling of stemness maintenance with cell cycle control in stem cells	59
Comparison of plasma- and saliva-derived exosomal miRNA profiles reveals diagnostic potential in head and neck cancer	59
Connexin 30 deletion exacerbates cochlear senescence and age-related hearing loss	59
Effects of Transcription-Dependent Physical Perturbations on the Chromosome Dynamics in Living Cells	59
Morinda officinalis oligosaccharides attenuate mitochondria-associated ferroptosis via the NOX4/mitoGPX4 pathway in myocardial ischemia‒reperfusion injury	58
Targeted Plasmalogen Supplementation: Effects on Blood Plasmalogens, Oxidative Stress Biomarkers, Cognition, and Mobility in Cognitively Impaired Persons	58
Systemic inflammatory regulators and risk of acute-on-chronic liver failure: A bidirectional mendelian-randomization study	57
Single-cell RNA sequencing reveals cell subpopulations in the tumor microenvironment contributing to hepatocellular carcinoma	57

The tendon interfascicular basement membrane provides a vascular niche for CD146+ cell subpopulations	57
MicroRNAs and long non-coding RNAs in cartilage homeostasis and osteoarthritis	57
Liver X Receptors (LXRs) in cancer-an Eagle’s view on molecular insights and therapeutic opportunities	57
Differential regulation of MYC expression by PKHD1/Pkhd1 in human and mouse kidneys: phenotypic implications for recessive polycystic kidney disease	56
Modeling the spatiotemporal properties of crosstalk between RyR-mediated and IP3R-mediated local Ca2+ release	56
Widespread distribution of lymphatic vessels in human dura mater remote from sinus veins	56
Quantitative analysis of Robertsonian chromosomes inherited by descendants from multiple Rb heterozygotes of Mus m. Domesticus	56
Regulation of insulin secretion by the post-translational modifications	55
Prolactin drives cortical neuron maturation and dendritic development during murine embryonic stem cell differentiation	55
The Mkx- TGF-β pathway induced the development of the myodural bridge complex in SD rats	55
Mitochondrial epigenetic mechanisms in cancer: an updated overview	54
From organelles to therapy: rethinking combined hepatocellular-cholangiocarcinoma	54
Editorial: Personalized medicine for neuromuscular disorders	54
The roles of lncRNA functions and regulatory mechanisms in the diagnosis and treatment of hepatocellular carcinoma	54
Resolution of inflammation during rheumatoid arthritis	53
Getting cells into shape by calcium-dependent actin cross-linking proteins	53
G-patch proteins: important regulators of pre-mRNA splicing and ribosome biogenesis	53
Research progress in deep learning-based fundus image analysis for the diagnosis and prediction of hypertension-related diseases	52
BDNF-loaded chitosan-based mimetic mussel polymer conduits for repair of peripheral nerve injury	52
Enhancement of chemotherapeutic efficacy via non-canonical autophagy induced by Olea europaea in human model of lung adenocarcinoma cells (A549)	51
Limb Mesoderm and Head Ectomesenchyme Both Express a Core Transcriptional Program During Chondrocyte Differentiation	51
Kinase PLK1 regulates the disassembly of the lateral elements and the assembly of the inner centromere during the diakinesis/metaphase I transition in male mouse meiosis	51
Structural regulation and dynamic behaviour of organelles during plant meiosis	50
Roles of RNA-binding proteins in macrophage function regulation and immunotherapy	50
Paternal impact on the developmental programming of sexual dimorphism	50
Venetoclax durable response in adult relapsed/refractory Philadelphia-negative acute lymphoblastic leukemia with JAK/STAT pathway alterations	49
Impact of WTAP in small HCC and paired adjacent non-neoplastic liver tissue on recurrence: A cohort study with external extension analysis	49
Synovial sarcoma of the head and neck: A review of reported cases on the clinical characteristics and treatment methods	49
The crosstalk between MYC and mTORC1 during osteoclastogenesis	49
Mechano-biochemical marine stimulation of inversion, gastrulation, and endomesoderm specification in multicellular Eukaryota	49
Crossover interference mechanism: New lessons from plants	48
Advances in understanding the regulation of pluripotency fate transition in embryonic stem cells	48
Characterization of Genomic Alterations in Colorectal Liver Metastasis and Their Prognostic Value	47
Regeneration of the dermal skeleton and wound epidermis formation depend on BMP signaling in the caudal fin of platyfish	47
Ultra-short laser processing of 3D bioceramic, porous scaffolds designed by freeze foaming method for orthopedic applications	46
Tumor suppressor function of formyl peptide receptor 1 in gastrointestinal cancers: a focus on the underlying signaling	46
Targeting microglia polarization with Chinese herb-derived natural compounds for neuroprotection in ischemic stroke	46
A multi-mineral intervention to counter pro-inflammatory activity and to improve the barrier in human colon organoids	46
A review of cell death pathways in hemorrhagic stroke	46
Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles	45
Epigenetic and transcriptomic alterations in the ClC-3-deficient mice consuming a normal diet	45
Synergy between a cytoplasmic vWFA/VIT protein and a WD40-repeat F-box protein controls development in Dictyostelium	45
Transcriptional profiling identifies IL-33-expressing intestinal stromal cells as a signaling hub poised to interact with enteric neurons	45
Blimp-1/PRDM1 and Hr3/RORβ specify the blue-sensitive photoreceptor subtype in Drosophila by repressing the hippo pathway	44
The long-term neurodevelopmental outcomes of febrile seizures and underlying mechanisms	44
Cell-free regenerative medicine: identifying the best source of mesenchymal stem cells for skin therapy in Systemic Sclerosis	44
Amyloid-induced mitochondrial network disruption in neurons monitored by STED super-resolution imaging	44
Autophagy, innate immunity, and cardiac disease	44
Caloric restriction induced epigenetic effects on aging	44
CCL2 promotes osteogenesis by facilitating macrophage migration during acute inflammation	44
Hypoxia-sensitive miRNA regulation via CRISPR/dCas9 loaded in hybrid exosomes: A novel strategy to improve embryo implantation and prevent placental insufficiency during pregnancy	44
Engineered exosomes: a promising design platform for overcoming cancer therapy resistance	44
Perspectives on the α5 nicotinic acetylcholine receptor in lung cancer progression	44
Mechanisms of CAR T cell exhaustion and current counteraction strategies	44
Disruption of fos causes craniofacial anomalies in developing zebrafish	44
JAZF1: A metabolic actor subunit of the NuA4/TIP60 chromatin modifying complex	43
Aquaporin-8 transports hydrogen peroxide to regulate granulosa cell autophagy	43
Control of mitochondrial dynamics and apoptotic pathways by peroxisomes	43
Quercetin protects porcine oocytes from in vitro aging by reducing oxidative stress and maintaining the mitochondrial functions	43
H19 and IGF2 imprinting from embryogenesis to oncogenesis	43
Interferon-primed immune landscapes predict immune-related adverse events during immune checkpoint inhibitor therapy	43
N6-methyladenosine RNA methylation: From regulatory mechanisms to potential clinical applications	42
mTORC2 protects the heart from high-fat diet-induced cardiomyopathy through mitochondrial fission in Drosophila	42
GNA13 promotes brain metastasis of non-small cell lung cancer and EMT through the WNT/β catenin signaling pathway	42
Cervical cancer benefits from trabectedin combination with the β-blocker propranolol: in vitro and ex vivo evaluations in patient-derived organoids	42
Evaluation of the effect of GSK-3β on liver cancer based on the PI3K/AKT pathway	42
Advances in Traditional Chinese Medicine for chronic obstructive pulmonary disease through multi-omics approaches	42
Cyclodextrin nanoparticles for diagnosis and potential cancer therapy: A systematic review	42
Vimentin Tail Segments Are Differentially Exposed at Distinct Cellular Locations and in Response to Stress	41
Tumor resident microbiota and response to therapies: An insight on tissue bacterial microbiota	41
Iron-mediated oxidative stress induces PD-L1 expression via activation of c-Myc in lung adenocarcinoma	41
PLANAtools—An interactive gene expression repository for the planarian Schmidtea mediterranea	41
From a stem-cell–centered to a niche-centered view: the core role of collagen networks in hair loss and hair follicle miniaturization	41
In-silico pharmacological insights into the therapeutic potential of microRNAs for microplastic-associated cancers	41
Development, regeneration, and physiological expansion of functional β-cells: Cellular sources and regulators	41
A FOS/NFKB1-associated Hofbauer cell subset mediates placental niche dysregulation in early-onset fetal growth restriction	41
Mitochondrial DNA abnormalities and metabolic syndrome	41
Mesenchymal stromal/stem cell-derived exosomes as a potential therapeutic approach to osteoarthritis combined with type 2 diabetes mellitus	41
Of mice and men: Pinpointing species differences in adipose tissue biology	40
Interactions between glioblastoma and myeloid cells	40

Palmitoyltransferase DHHC7 mediates protein palmitoylation and is essential for sperm function through the modulation of [Ca2+]i and ROS signaling	40
Role of microglia in diabetic neuropathic pain	40
Deciphering the triad of endothelial glycocalyx, von Willebrand Factor, and P-selectin in inflammation-induced coagulation	40
Squeezing the eggs to grow: The mechanobiology of mammalian folliculogenesis	40
Involvement of role of HMGB1-NLRP3 pathway in systemic disorders	40
Molecular and therapeutic advancements in Capicua (CIC)-rearranged sarcoma	40
Emerin interacts with histone methyltransferases to regulate repressive chromatin at the nuclear periphery	40
The role of retinal Müller cells in diabetic retinopathy and related therapeutic advances	39
Mathematical modeling and application of IL-1β/TNF signaling pathway in regulating chondrocyte apoptosis	39
Cancer stem cells are prevalent in the basal-like 2 and mesenchymal triple-negative breast cancer subtypes in vitro	39
B cell-T cell interplay in immune regulation: A focus on follicular regulatory T and regulatory B cell functions	39
Amelioration of pregnancy outcomes in a pregnant rat model with deep venous thrombosis following the transplantation of bone marrow mesenchymal stem cells	39
Weibel-Palade bodies – secretory organelles at the interface of inflammation and hemostasis	39
Regulation of Malignant Myeloid Leukemia by Mesenchymal Stem Cells	39
Embryonic Programs in Cancer and Metastasis—Insights From the Mammary Gland	38
Quercetin improves and protects Calu-3 airway epithelial barrier function	38
Carcinogenesis trajectories	38
Embryo-derived trypsin-induced calcium entry is inhibited by endometrial infertility factor, LEFTY2	38
Mechanistic insights into adipose-derived stem cells and exosomes in ischemia-reperfusion injury repair: from shared pathways to organ-specific therapeutics	38
Taste receptors affect male reproduction by influencing steroid synthesis	38
Lung epithelial-endothelial-mesenchymal signaling network with hepatocyte growth factor as a hub is involved in bronchopulmonary dysplasia	38
Exploring the protective mechanisms of the yunpi jiedu tongluo qushi decoction on methotrexate-induced reproductive damage in male rats based on Nrf2/HO-1 signaling pathway	38
A Single-Cell Characterization of Human Post-implantation Embryos Cultured In Vitro Delineates Morphogenesis in Primary Syncytialization	38
Porcn is essential for growth and invagination of the mammalian optic cup	38
NOC1 is a direct MYC target, and its protein interactome dissects its activity in controlling nucleolar function	38
Zebrafish cobll1a regulates lipid homeostasis via the RA signaling pathway	38
Transcriptional regulation in the absence of inositol trisphosphate receptor calcium signaling	38
Two distinct forms of human BLT2: long-form and short-form BLT2	37
SIRT3/6/7: promising therapeutic targets for pulmonary fibrosis	37
Diabetic encephalopathy: metabolic reprogramming as a potential driver of accelerated brain aging and cognitive decline	37
Drosophila: a Tale of regeneration with MYC	37
Editorial: Functions and regulation of p90RSK and its family: mechanisms, roles in diseases, and implications in therapeutics	37
JAK/STAT signaling in diabetic kidney disease	37
Correction: Polychlorinated biphenyls and breast cancer evidence, mechanisms, and risk management	37
Axonal regeneration and innervation ratio following supercharged end-to-side nerve transfer	37
Role of exosomes and exosomal microRNA in muscle–Kidney crosstalk in chronic kidney disease	37
Surface decorated quantum dots: Synthesis, properties and role in herbal therapy	37
Integrative single-cell and bulk RNA sequencing unravels the role of ACTN1 in promoting lung cancer with brain metastasis and epidermal growth factor receptor-tyrosine kinase inhibitor resistance	37
LncRNA model predicts liver cancer drug resistance and validate in vitro experiments	37
Different seminal ejaculated fractions in artificial insemination condition the protein cargo of oviductal and uterine extracellular vesicles in pig	36
Long-term efficacy and safety of sirolimus for retinal astrocytic hamartoma associated with tuberous sclerosis complex	36
Editorial: Current methods for detecting and diagnosing stem cell pathogenesis: a focus on translational interventions in the contemporary disease and technology landscape	36
Significance of Liver Zonation in Hepatocellular Carcinoma	36
Mfsd8 Modulates Growth and the Early Stages of Multicellular Development in Dictyostelium discoideum	36
MicroRNA: role in macrophage polarisation and colorectal cancer pathogenesis	36
MicroRNA target homeobox messenger RNA in HIV induced hematopoietic inhibition	36
Integrins in cancer stem cells	36
Chromatin remodeling complexes: architects influencing breast cancer progression	36
Augmenting mesenchymal stem cell therapy for osteoarthritis via inflammatory priming: a comparative study on mesenchymal stem cells derived from various perinatal tissue sources	36
The fibularis tertius muscle revisited: comparative anatomy, developmental classification, and evolutionary-clinical implications	36
Editorial: Mechanisms of hox-driven patterning and morphogenesis	35
Extremely low-frequency electromagnetic fields facilitate both osteoblast and osteoclast activity through Wnt/β-catenin signaling in the zebrafish scale	35
Flow-cytometry reveals mitochondrial DNA accumulation in Saccharomyces cerevisiae cells during cell cycle arrest	35
Prognosis and therapeutic significance of IGF-1R-related signaling pathway gene signature in glioma	35
Nanotopographic control of actin waves and growth cone navigation in developing neurons	35
Study on the mechanism of MDSC-platelets and their role in the breast cancer microenvironment	35
Diabetes and SARS-CoV-2–Is There a Mutual Connection?	35
Azithromycin mitigates human rhinovirus impact on barrier integrity and function in non-diseased airway epithelium	35
PtosisDiffusion: a training-free workflow for precisely predicting post-operative appearance in blepharoptosis patients based on diffusion models	35
Comparative analysis of retinal vascular structural parameters in populations with different glucose metabolism status based on color fundus photography and artificial intelligence	35
Chloroquine mitigates long-term effects of in vitro culture in mouse embryos	35
Insulin secretion hot spots in pancreatic β cells as secreting adhesions	35
Cyclins and CDKs in the regulation of meiosis-specific events	35
A novel chemical genetic approach reveals paralog-specific role of ERK1/2 in mouse embryonic stem cell fate control	35
Characterization of disease-specific alterations in metabolites and effects of mesenchymal stromal cells on dystrophic muscles	35
Metabolomic profiling and biomarker identification for early detection and therapeutic targeting of doxorubicin-induced cardiotoxicity	35
The ambivalent nature of the relationship between lymphatics and cancer	35
Combined 3D bioprinting and tissue-specific ECM system reveals the influence of brain matrix on stem cell differentiation	35
The odontoblastic differentiation of dental mesenchymal stem cells: molecular regulation mechanism and related genetic syndromes	35
Editorial: Reviews in induced pluripotent stem cells	35
Editorial: Editors’ showcase 2021: Insights in cell growth and division	34
Metabolic control of induced pluripotency	34
Interaction between epidermal growth factor receptor and C-C motif chemokine receptor 2 in the ovulatory cascade	34
Editorial: Stem cell therapy for hereditary neuromuscular diseases	34
Correction: Lmx1a is essential for marginal cell differentiation and stria vascularis formation	34
Roles of retrovirus-derived PEG10 and PEG11/RTL1 in mammalian development and evolution and their involvement in human disease	34
Editorial: Microtubule-associated molecular motors: Transport mechanisms and role in disease	34
GCN5L: a critical target in energy metabolism pathways	34
Unraveling the path to osteoarthritis management: targeting chondrocyte apoptosis for therapeutic intervention	34
The promising roles of macrophages in geriatric hip fracture	34
Comparison of modulation efficiency between normal and degenerated primate retina	34
Circular RNA-regulated autophagy is involved in cancer progression	34
Regulation of p53 by the mitotic surveillance/stopwatch pathway: implications in neurodevelopment and cancer	34
ATM Modulates Nuclear Mechanics by Regulating Lamin A Levels	34
Editorial: The fertilization success from the Oocyte’s perspective, volume II	34
Salivary miRNAs and cytokines associated with diagnosis and prognosis of oral squamous cell carcinoma	34
Immune cell infiltration and the genes associated with ligamentum flavum hypertrophy: Identification and validation	34
Transcriptomic insights into developmental arrest in fluorescent labeling transgenic Asian elephant (Elephas maximus) embryos via inter-order cloning	34
Ferroptosis Associates With Diagnosis and Prognosis by Promoting Antitumor Immune Response in Melanoma	34
Cells Dynamically Adapt to Surface Geometry by Remodeling Their Focal Adhesions and Actin Cytoskeleton	34
Stem cell activation in organ culture reveals novel transcriptional programs underlying metabolic, fibrotic, vascular, and immune dysregulation in uterine leiomyomas	34
Pathogenesis and treatment of neuropsychiatric systemic lupus erythematosus: A review	34
Multi-omics analysis reveals a protective role of endogenous proline in sheep oocyte vitrification and its therapeutic application	33
The polar code for patterning: how polarity and the cytoskeleton orchestrate asymmetric cell division during plant development	33
ZebraReg—a novel platform for discovering regulators of cardiac regeneration using zebrafish	33