Frontiers in Cell and Developmental Biology

Article	Citations
Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype	611
Iron Metabolism in Ferroptosis	403
PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor Resistance	305
Mitophagy, Mitochondrial Homeostasis, and Cell Fate	294
Oxidative Damage and Antioxidant Defense in Ferroptosis	257
Beneficial and Detrimental Effects of Reactive Oxygen Species on Lifespan: A Comprehensive Review of Comparative and Experimental Studies	208
Resistance Mechanisms of Anti-PD1/PDL1 Therapy in Solid Tumors	200
Characteristics and Biomarkers of Ferroptosis	197
MicroRNAs: From Mechanism to Organism	192
Metabolism of Amino Acids in Cancer	178
The Keloid Disorder: Heterogeneity, Histopathology, Mechanisms and Models	150
In vitro Models of Neurodegenerative Diseases	145
The Balance of TNF Mediated Pathways Regulates Inflammatory Cell Death Signaling in Healthy and Diseased Tissues	144
Senescence in Mesenchymal Stem Cells: Functional Alterations, Molecular Mechanisms, and Rejuvenation Strategies	142
TGF-β-Induced Endothelial to Mesenchymal Transition in Disease and Tissue Engineering	135
Molecular Bases of VEGFR-2-Mediated Physiological Function and Pathological Role	133
The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy	132
The Emerging Role of the Mammalian Glycocalyx in Functional Membrane Organization and Immune System Regulation	127
Selective Targeting of TNF Receptors as a Novel Therapeutic Approach	126
On-Target Anti-TGF-β Therapies Are Not Succeeding in Clinical Cancer Treatments: What Are Remaining Challenges?	124
The Pyroptosis-Related Signature Predicts Prognosis and Indicates Immune Microenvironment Infiltration in Gastric Cancer	122
Comparative Analysis of BTK Inhibitors and Mechanisms Underlying Adverse Effects	121
The mTOR–Autophagy Axis and the Control of Metabolism	119
Interplay Between Lipid Metabolism and Autophagy	112
Immunomodulatory Effect of Adipose-Derived Stem Cells: The Cutting Edge of Clinical Application	112

N6-Methylandenosine-Related lncRNAs Are Potential Biomarkers for Predicting the Overall Survival of Lower-Grade Glioma Patients	111
Premature Ovarian Insufficiency: Past, Present, and Future	109
Endometrial and Menstrual Blood Mesenchymal Stem/Stromal Cells: Biological Properties and Clinical Application	105
The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines	105
Cathepsin K: The Action in and Beyond Bone	105
Exosomes, a New Star for Targeted Delivery	105
Mechanoregulation of YAP and TAZ in Cellular Homeostasis and Disease Progression	105
Targeting Rho GTPase Signaling Networks in Cancer	103
The Role of Exosomes and Exosomal MicroRNA in Cardiovascular Disease	102
Recent Advances of Osterix Transcription Factor in Osteoblast Differentiation and Bone Formation	102
Laboratory Testing Methods for Novel Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2)	102
Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma: Origin, Polarization, Function, and Reprogramming	101
The Mechanics of Mitotic Cell Rounding	99
Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression	99
Role of Epithelial-Mesenchymal Transition in Retinal Pigment Epithelium Dysfunction	97
Liver Fibrosis: Therapeutic Targets and Advances in Drug Therapy	97
Tumor Endothelial Cells (TECs) as Potential Immune Directors of the Tumor Microenvironment – New Findings and Future Perspectives	97
Tumor Microenvironment in Ovarian Cancer: Function and Therapeutic Strategy	96
The Ageing Brain: Molecular and Cellular Basis of Neurodegeneration	95
BMSC-Derived Exosomal miR-29a Promotes Angiogenesis and Osteogenesis	94
Bearing My Heart: The Role of Extracellular Matrix on Cardiac Development, Homeostasis, and Injury Response	92
The Role of Autophagy in Osteoarthritis	91
GAP-43 and BASP1 in Axon Regeneration: Implications for the Treatment of Neurodegenerative Diseases	90
The Inhibitory Effect of Curcumin on Virus-Induced Cytokine Storm and Its Potential Use in the Associated Severe Pneumonia	90
Structural and Functional Dysbiosis of Fecal Microbiota in Chinese Patients With Alzheimer's Disease	89
Molecular Mechanisms of Cardiomyocyte Death in Drug-Induced Cardiotoxicity	89
Physiological Signaling Functions of Reactive Oxygen Species in Stem Cells: From Flies to Man	89
Hepatic Stellate Cells and Hepatocarcinogenesis	87
Targeting Cell Death: Pyroptosis, Ferroptosis, Apoptosis and Necroptosis in Osteoarthritis	87
Epigenetics of Male Infertility: The Role of DNA Methylation	86
Single-Cell RNA-seq Identifies Cell Subsets in Human Placenta That Highly Expresses Factors Driving Pathogenesis of SARS-CoV-2	86
Roles of Macrophages in the Development and Treatment of Gut Inflammation	86
Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds	86
The Extracellular Matrix in Skin Inflammation and Infection	86
Notch Signaling in Vascular Endothelial Cells, Angiogenesis, and Tumor Progression: An Update and Prospective	85
Regulatory Mechanisms of Vitellogenesis in Insects	85
Biological Function of Long Non-coding RNA (LncRNA) Xist	85
Nicotinamide Mononucleotide: A Promising Molecule for Therapy of Diverse Diseases by Targeting NAD+ Metabolism	84
New Insights of Emerging SARS-CoV-2: Epidemiology, Etiology, Clinical Features, Clinical Treatment, and Prevention	84
Cancer-Associated Fibroblast (CAF) Heterogeneity and Targeting Therapy of CAFs in Pancreatic Cancer	83
Selective Autophagy Receptor p62/SQSTM1, a Pivotal Player in Stress and Aging	83
The Epithelial-to-Mesenchymal Transition as a Possible Therapeutic Target in Fibrotic Disorders	82
Deciphering Epitranscriptome: Modification of mRNA Bases Provides a New Perspective for Post-transcriptional Regulation of Gene Expression	82
MitophAging: Mitophagy in Aging and Disease	82
Mitochondrial Transfer and Regulators of Mesenchymal Stromal Cell Function and Therapeutic Efficacy	81
Recent Trends in the Development of Bone Regenerative Biomaterials	80
Horizontal Gene Transfer: From Evolutionary Flexibility to Disease Progression	80
The Role of Notch, Hedgehog, and Wnt Signaling Pathways in the Resistance of Tumors to Anticancer Therapies	80
Mitochondrial Dynamics: Fission and Fusion in Fate Determination of Mesenchymal Stem Cells	80
Mesenchymal Stem Cell Senescence and Rejuvenation: Current Status and Challenges	79

Development and Validation of a Combined Ferroptosis and Immune Prognostic Classifier for Hepatocellular Carcinoma	78
Targeting Mitochondrial Impairment in Parkinson's Disease: Challenges and Opportunities	77
Signaling Pathways Involved in Diabetic Renal Fibrosis	77
Scalable Production of Human Mesenchymal Stromal Cell-Derived Extracellular Vesicles Under Serum-/Xeno-Free Conditions in a Microcarrier-Based Bioreactor Culture System	77
Named Entity Recognition and Relation Detection for Biomedical Information Extraction	77
The Why of YY1: Mechanisms of Transcriptional Regulation by Yin Yang 1	77
Severity Detection for the Coronavirus Disease 2019 (COVID-19) Patients Using a Machine Learning Model Based on the Blood and Urine Tests	77
Role of Wnt Signaling in Adult Hippocampal Neurogenesis in Health and Disease	77
The “Neuro-Glial-Vascular” Unit: The Role of Glia in Neurovascular Unit Formation and Dysfunction	77
The Role of Mitochondrial Dynamics and Mitophagy in Carcinogenesis, Metastasis and Therapy	76
Macrophage Dysregulation and Impaired Skin Wound Healing in Diabetes	76
Mitochondria-Associated ER Membranes – The Origin Site of Autophagy	76
Development of Extracellular Vesicle Therapeutics: Challenges, Considerations, and Opportunities	75
Immunomodulatory Properties of Mesenchymal Stromal Cells: An Update	75
CXCL11 Correlates With Antitumor Immunity and an Improved Prognosis in Colon Cancer	75
Connective Tissue Growth Factor: From Molecular Understandings to Drug Discovery	75
The Current Status of Mesenchymal Stromal Cells: Controversies, Unresolved Issues and Some Promising Solutions to Improve Their Therapeutic Efficacy	74
Epithelial-Mesenchymal Transition and Metabolic Switching in Cancer: Lessons From Somatic Cell Reprogramming	74
Characterization of Human Colon Organoids From Inflammatory Bowel Disease Patients	72
Long Non-coding RNAs and MicroRNAs Interplay in Osteogenic Differentiation of Mesenchymal Stem Cells	72
The Integral Role of RNA in Stress Granule Formation and Function	71
ORF3a-Mediated Incomplete Autophagy Facilitates Severe Acute Respiratory Syndrome Coronavirus-2 Replication	71
Evaluating DNA Methylation, Gene Expression, Somatic Mutation, and Their Combinations in Inferring Tumor Tissue-of-Origin	71
The Therapeutic Potential of Mesenchymal Stromal Cells for Regenerative Medicine: Current Knowledge and Future Understandings	71
Transmission Routes Analysis of SARS-CoV-2: A Systematic Review and Case Report	71
Tissue-Resident Macrophage Development and Function	70
Exosomal miRNA-16-5p Derived From M1 Macrophages Enhances T Cell-Dependent Immune Response by Regulating PD-L1 in Gastric Cancer	70
Adipogenesis, Osteogenesis, and Chondrogenesis of Human Mesenchymal Stem/Stromal Cells: A Comparative Transcriptome Approach	70
Glucose Metabolism and Glucose Transporters in Breast Cancer	70
Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3): Unraveling the Role in Mediating IGF-Independent Effects Within the Cell	69
The Neurovascular Unit in Glaucomatous Neurodegeneration	69
The Role of Tumor-Stroma Interactions in Drug Resistance Within Tumor Microenvironment	69
Brain Neurotransmitter Modulation by Gut Microbiota in Anxiety and Depression	68
Role of YAP/TAZ in Cell Lineage Fate Determination and Related Signaling Pathways	68
Mitochondria-Associated Endoplasmic Reticulum Membranes in Cardiovascular Diseases	68
An Eight-CircRNA Assessment Model for Predicting Biochemical Recurrence in Prostate Cancer	68
Pluripotent Stem Cell Therapies for Parkinson Disease: Present Challenges and Future Opportunities	67
Therapeutic Use of Mesenchymal Stromal Cells: The Need for Inclusive Characterization Guidelines to Accommodate All Tissue Sources and Species	67
Adaptive Mechanisms of Tumor Therapy Resistance Driven by Tumor Microenvironment	67
Running Against the Wnt: How Wnt/β-Catenin Suppresses Adipogenesis	66
Communications Between Bone Marrow Macrophages and Bone Cells in Bone Remodeling	66
The Senolytic Drug Navitoclax (ABT-263) Causes Trabecular Bone Loss and Impaired Osteoprogenitor Function in Aged Mice	66
Molecular Aspects and Future Perspectives of Cytokine-Based Anti-cancer Immunotherapy	65
Blockade of GCH1/BH4 Axis Activates Ferritinophagy to Mitigate the Resistance of Colorectal Cancer to Erastin-Induced Ferroptosis	65
MicroRNA-34a: Potent Tumor Suppressor, Cancer Stem Cell Inhibitor, and Potential Anticancer Therapeutic	65
Complement Receptors and Their Role in Leukocyte Recruitment and Phagocytosis	65
Regeneration of Functional Neurons After Spinal Cord Injury via in situ NeuroD1-Mediated Astrocyte-to-Neuron Conversion	65
Mesenchymal Stromal Cells as Critical Contributors to Tissue Regeneration	64
Effect of Nuclear Stiffness on Cell Mechanics and Migration of Human Breast Cancer Cells	64
Mutant p53 Gain-of-Function: Role in Cancer Development, Progression, and Therapeutic Approaches	64
The Application of Brain Organoids: From Neuronal Development to Neurological Diseases	64
B Cell Orchestration of Anti-tumor Immune Responses: A Matter of Cell Localization and Communication	64
From Flies to Men: ROS and the NADPH Oxidase in Phagocytes	63
Mesenchymal Stromal Cells and Exosomes: Progress and Challenges	63
TGF-β Signaling and Resistance to Cancer Therapy	63
m6A Regulators Is Differently Expressed and Correlated With Immune Response of Esophageal Cancer	62
Exosomes From Adipose-Derived Stem Cells: The Emerging Roles and Applications in Tissue Regeneration of Plastic and Cosmetic Surgery	61
Targeting Rac and Cdc42 GEFs in Metastatic Cancer	61
The Roles of 2-Hydroxyglutarate	61
Role of Cholesterol and Lipid Rafts in Cancer Signaling: A Promising Therapeutic Opportunity?	61
LRP5 and LRP6 in Wnt Signaling: Similarity and Divergence	61
Bone and Muscle Crosstalk in Aging	61
H3K4me1 Distribution Predicts Transcription State and Poising at Promoters	61
Guidelines for Regulated Cell Death Assays: A Systematic Summary, A Categorical Comparison, A Prospective	60
Multiple Functions of ATG8 Family Proteins in Plant Autophagy	60
A Guide to Nucleic Acid Vaccines in the Prevention and Treatment of Infectious Diseases and Cancers: From Basic Principles to Current Applications	60
Neuron-Oligodendrocyte Interactions in the Structure and Integrity of Axons	59
Thyroid Hormones Interaction With Immune Response, Inflammation and Non-thyroidal Illness Syndrome	59
New Insights Into Targeting Membrane Lipids for Cancer Therapy	59
Mitochondrial Function and Dysfunction in Dilated Cardiomyopathy	59
Ferroptosis in Acute Central Nervous System Injuries: The Future Direction?	59
CircRNA Is a Rising Star in Researches of Ocular Diseases	59
Primary Cilia, Ciliogenesis and the Actin Cytoskeleton: A Little Less Resorption, A Little More Actin Please	59
Cyclin E/CDK2: DNA Replication, Replication Stress and Genomic Instability	59
Natural Compounds and Autophagy: Allies Against Neurodegeneration	58
Cell-Free DNA: Hope and Potential Application in Cancer	58
Ran GTPase: A Key Player in Tumor Progression and Metastasis	58
Targeting USP7-Mediated Deubiquitination of MDM2/MDMX-p53 Pathway for Cancer Therapy: Are We There Yet?	58
Subchondral Bone Remodeling: A Therapeutic Target for Osteoarthritis	58
Targeting Immune Cells in the Tumor Microenvironment of HCC: New Opportunities and Challenges	58

Obesity and Bone Health: A Complex Link	57
Mechanisms of Oocyte Maturation and Related Epigenetic Regulation	57
Dissecting the Crosstalk Between Nrf2 and NF-κB Response Pathways in Drug-Induced Toxicity	57
The Mitochondrial Response to DNA Damage	57
Emerging Roles of Exosomal Circular RNAs in Cancer	56
Modeling Inflammation in Zebrafish for the Development of Anti-inflammatory Drugs	56
Identifying Transcriptomic Signatures and Rules for SARS-CoV-2 Infection	56
Two Types of Contact Between Lipid Droplets and Mitochondria	56
Cancer Stem Cells: Emerging Key Players in Immune Evasion of Cancers	56
A Novel Ten-Gene Signature Predicting Prognosis in Hepatocellular Carcinoma	56
N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and Applications	55
Endothelial-to-Mesenchymal Transition in Cancer	55
Prognostic Significance and Tumor Immune Microenvironment Heterogenicity of m5C RNA Methylation Regulators in Triple-Negative Breast Cancer	55
Quercetin Suppresses Apoptosis and Attenuates Intervertebral Disc Degeneration via the SIRT1-Autophagy Pathway	55
A Critical Perspective on 3D Liver Models for Drug Metabolism and Toxicology Studies	55
The Role of Short-Chain Fatty Acids and Bile Acids in Intestinal and Liver Function, Inflammation, and Carcinogenesis	55
Cadmium-Induced Cytotoxicity: Effects on Mitochondrial Electron Transport Chain	55
New Understanding of the Relevant Role of LINE-1 Retrotransposition in Human Disease and Immune Modulation	54
Mesenchymal Stem Cells Adaptively Respond to Environmental Cues Thereby Improving Granulation Tissue Formation and Wound Healing	54
Exosomal PD-L1: New Insights Into Tumor Immune Escape Mechanisms and Therapeutic Strategies	54
Regulation of V-ATPase Activity and Organelle pH by Phosphatidylinositol Phosphate Lipids	54
In vivo Neuroregeneration to Treat Ischemic Stroke Through NeuroD1 AAV-Based Gene Therapy in Adult Non-human Primates	54
Insights Into the Role of CircRNAs: Biogenesis, Characterization, Functional, and Clinical Impact in Human Malignancies	54
The Role of Gut Microbial β-Glucuronidase in Estrogen Reactivation and Breast Cancer	54
Mesenchymal Stem Cell-Macrophage Crosstalk and Maintenance of Inflammatory Microenvironment Homeostasis	54
Down-Regulated Exosomal MicroRNA-221 – 3p Derived From Senescent Mesenchymal Stem Cells Impairs Heart Repair	54
Mitochondrial Function in Muscle Stem Cell Fates	54
Mitochondrial OMA1 and OPA1 as Gatekeepers of Organellar Structure/Function and Cellular Stress Response	53
USP7 Is a Master Regulator of Genome Stability	53
Liraglutide Alleviates Hepatic Steatosis by Activating the TFEB-Regulated Autophagy-Lysosomal Pathway	53
Mitochondrial Dynamics in Adult Cardiomyocytes and Heart Diseases	53
Mitochondria Donation by Mesenchymal Stem Cells: Current Understanding and Mitochondria Transplantation Strategies	53
The Dimensions of Primary Mitochondrial Disorders	53
HGF and MET: From Brain Development to Neurological Disorders	52
The MicroRNA Family Gets Wider: The IsomiRs Classification and Role	52
Global Research Trends of Ferroptosis: A Rapidly Evolving Field With Enormous Potential	52
The Role of ARF Family Proteins and Their Regulators and Effectors in Cancer Progression: A Therapeutic Perspective	52
Niches for Skeletal Stem Cells of Mesenchymal Origin	52
Is Senescence-Associated β-Galactosidase a Reliable in vivo Marker of Cellular Senescence During Embryonic Development?	52
Osteoclast Signal Transduction During Bone Metastasis Formation	52
The Nrf2 Pathway in Liver Diseases	52
Ion Transport in Eryptosis, the Suicidal Death of Erythrocytes	52
COVID-19 and the Vasculature: Current Aspects and Long-Term Consequences	52
Development and Validation of a Robust Ferroptosis-Related Prognostic Signature in Lung Adenocarcinoma	52
Fusobacterium nucleatum Acts as a Pro-carcinogenic Bacterium in Colorectal Cancer: From Association to Causality	51
Telomere Replication: Solving Multiple End Replication Problems	51
Citicoline Protects Auditory Hair Cells Against Neomycin-Induced Damage	51
Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Lung Diseases: Current Status and Perspectives	51
nCOVID-19 Pandemic: From Molecular Pathogenesis to Potential Investigational Therapeutics	51
CD226: An Emerging Role in Immunologic Diseases	51
The Role of Proteoglycans in Cancer Metastasis and Circulating Tumor Cell Analysis	50
A Prognostic Ferroptosis-Related lncRNAs Signature Associated With Immune Landscape and Radiotherapy Response in Glioma	50
Expression of m6A Regulators Correlated With Immune Microenvironment Predicts Therapeutic Efficacy and Prognosis in Gliomas	50
Genetic Engineering as a Strategy to Improve the Therapeutic Efficacy of Mesenchymal Stem/Stromal Cells in Regenerative Medicine	50
Biophysical and Biochemical Cues of Biomaterials Guide Mesenchymal Stem Cell Behaviors	50
STING1 Promotes Ferroptosis Through MFN1/2-Dependent Mitochondrial Fusion	50
Molecular Crosstalk Between MYC and HIF in Cancer	50
Connecting the Dots: Resolving the Bone Marrow Niche Heterogeneity	50
Fibroblast Senescence in Idiopathic Pulmonary Fibrosis	50
Cardiomyocyte Proliferation and Maturation: Two Sides of the Same Coin for Heart Regeneration	50
Roles of N6-Methyladenosine (m6A) in Stem Cell Fate Decisions and Early Embryonic Development in Mammals	50
Insights on SARS-CoV-2 Molecular Interactions With the Renin-Angiotensin System	49
The Role of Astrocytes in the Neurorepair Process	49
The Paradoxical Role of Cellular Senescence in Cancer	49
Modeling Rett Syndrome With Human Patient-Specific Forebrain Organoids	49
Identification and Validation of Pyroptosis-Related Gene Signature to Predict Prognosis and Reveal Immune Infiltration in Hepatocellular Carcinoma	49
When Stiffness Matters: Mechanosensing in Heart Development and Disease	49
Extracellular Vesicles Derived From Apoptotic Cells: An Essential Link Between Death and Regeneration	48
Comparative Genomics of Peroxisome Biogenesis Proteins: Making Sense of the PEX Proteins	48
LncRNA KCNQ1OT1 Secreted by Tumor Cell-Derived Exosomes Mediates Immune Escape in Colorectal Cancer by Regulating PD-L1 Ubiquitination via MiR-30a-5p/USP22	48
Inflammation and Wnt Signaling: Target for Immunomodulatory Therapy?	48
Identification of CDK2-Related Immune Forecast Model and ceRNA in Lung Adenocarcinoma, a Pan-Cancer Analysis	48
Heterochromatin as an Important Driver of Genome Organization	48
Mesenchymal Stromal Cell-Produced Components of Extracellular Matrix Potentiate Multipotent Stem Cell Response to Differentiation Stimuli	48
Membrane-Interacting Antifungal Peptides	48
Nerves in the Tumor Microenvironment: Origin and Effects	48
Emerging Roles of Liquid–Liquid Phase Separation in Cancer: From Protein Aggregation to Immune-Associated Signaling	47
The Roles of Epigenetics Regulation in Bone Metabolism and Osteoporosis	47
Regulation of Myostatin on the Growth and Development of Skeletal Muscle	47
Recent Update of HDAC Inhibitors in Lymphoma	47
Exosome-Based Delivery of Natural Products in Cancer Therapy	47
Molecular Mechanisms of Chondrocyte Proliferation and Differentiation	47
Vertebrate Sensory Ganglia: Common and Divergent Features of the Transcriptional Programs Generating Their Functional Specialization	47
Reactive Oxygen Species: Not Omnipresent but Important in Many Locations	46
Structural Characteristics, Binding Partners and Related Diseases of the Calponin Homology (CH) Domain	46
Age-Related Macular Degeneration Revisited: From Pathology and Cellular Stress to Potential Therapies	46
Disease Activity-Associated Alteration of mRNA m5 C Methylation in CD4+ T Cells of Systemic Lupus Erythematosus	46
Induction of Autophagy by Pterostilbene Contributes to the Prevention of Renal Fibrosis via Attenuating NLRP3 Inflammasome Activation and Epithelial-Mesenchymal Transition	46
Integrating the Hallmarks of Aging Throughout the Tree of Life: A Focus on Mitochondrial Dysfunction	46
Midbrain Organoids: A New Tool to Investigate Parkinson’s Disease	46
MicroRNA-221/222 Mediates ADSC-Exosome-Induced Cardioprotection Against Ischemia/Reperfusion by Targeting PUMA and ETS-1	45
Neurovascular Coupling in Development and Disease: Focus on Astrocytes	45
Premyelinating Oligodendrocytes: Mechanisms Underlying Cell Survival and Integration	45
Autophagy, Pyroptosis, and Ferroptosis: New Regulatory Mechanisms for Atherosclerosis	45
Non-syndromic Cleft Palate: An Overview on Human Genetic and Environmental Risk Factors	45