Frontiers in Cell and Developmental Biology

Article	Citations
Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype	700
Iron Metabolism in Ferroptosis	465
PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor Resistance	343
Oxidative Damage and Antioxidant Defense in Ferroptosis	278
Beneficial and Detrimental Effects of Reactive Oxygen Species on Lifespan: A Comprehensive Review of Comparative and Experimental Studies	233
Resistance Mechanisms of Anti-PD1/PDL1 Therapy in Solid Tumors	221
Characteristics and Biomarkers of Ferroptosis	218
Metabolism of Amino Acids in Cancer	188
Molecular Bases of VEGFR-2-Mediated Physiological Function and Pathological Role	153
The mTOR–Autophagy Axis and the Control of Metabolism	143
The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy	139
Premature Ovarian Insufficiency: Past, Present, and Future	135
Comparative Analysis of BTK Inhibitors and Mechanisms Underlying Adverse Effects	133
On-Target Anti-TGF-β Therapies Are Not Succeeding in Clinical Cancer Treatments: What Are Remaining Challenges?	132
Exosomes, a New Star for Targeted Delivery	128
The Pyroptosis-Related Signature Predicts Prognosis and Indicates Immune Microenvironment Infiltration in Gastric Cancer	125
N6-Methylandenosine-Related lncRNAs Are Potential Biomarkers for Predicting the Overall Survival of Lower-Grade Glioma Patients	116
Mechanoregulation of YAP and TAZ in Cellular Homeostasis and Disease Progression	116
Tumor Microenvironment in Ovarian Cancer: Function and Therapeutic Strategy	113
The Role of Exosomes and Exosomal MicroRNA in Cardiovascular Disease	113
Recent Advances of Osterix Transcription Factor in Osteoblast Differentiation and Bone Formation	113
Endometrial and Menstrual Blood Mesenchymal Stem/Stromal Cells: Biological Properties and Clinical Application	113
The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines	111
Physiological Signaling Functions of Reactive Oxygen Species in Stem Cells: From Flies to Man	110
Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma: Origin, Polarization, Function, and Reprogramming	108

Tumor Endothelial Cells (TECs) as Potential Immune Directors of the Tumor Microenvironment – New Findings and Future Perspectives	107
BMSC-Derived Exosomal miR-29a Promotes Angiogenesis and Osteogenesis	107
The Ageing Brain: Molecular and Cellular Basis of Neurodegeneration	106
Liver Fibrosis: Therapeutic Targets and Advances in Drug Therapy	106
Selective Autophagy Receptor p62/SQSTM1, a Pivotal Player in Stress and Aging	106
The Mechanics of Mitotic Cell Rounding	105
Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression	102
Bearing My Heart: The Role of Extracellular Matrix on Cardiac Development, Homeostasis, and Injury Response	101
The Role of Autophagy in Osteoarthritis	101
Targeting Cell Death: Pyroptosis, Ferroptosis, Apoptosis and Necroptosis in Osteoarthritis	101
The Extracellular Matrix in Skin Inflammation and Infection	97
Recent Trends in the Development of Bone Regenerative Biomaterials	97
Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds	97
Biological Function of Long Non-coding RNA (LncRNA) Xist	96
Regulatory Mechanisms of Vitellogenesis in Insects	95
Epigenetics of Male Infertility: The Role of DNA Methylation	93
GAP-43 and BASP1 in Axon Regeneration: Implications for the Treatment of Neurodegenerative Diseases	92
Structural and Functional Dysbiosis of Fecal Microbiota in Chinese Patients With Alzheimer's Disease	92
Notch Signaling in Vascular Endothelial Cells, Angiogenesis, and Tumor Progression: An Update and Prospective	91
Cancer-Associated Fibroblast (CAF) Heterogeneity and Targeting Therapy of CAFs in Pancreatic Cancer	91
Single-Cell RNA-seq Identifies Cell Subsets in Human Placenta That Highly Expresses Factors Driving Pathogenesis of SARS-CoV-2	90
Roles of Macrophages in the Development and Treatment of Gut Inflammation	89
Deciphering Epitranscriptome: Modification of mRNA Bases Provides a New Perspective for Post-transcriptional Regulation of Gene Expression	89
Hepatic Stellate Cells and Hepatocarcinogenesis	88
The Epithelial-to-Mesenchymal Transition as a Possible Therapeutic Target in Fibrotic Disorders	88
Mitochondrial Dynamics: Fission and Fusion in Fate Determination of Mesenchymal Stem Cells	87
Scalable Production of Human Mesenchymal Stromal Cell-Derived Extracellular Vesicles Under Serum-/Xeno-Free Conditions in a Microcarrier-Based Bioreactor Culture System	87
The Role of Notch, Hedgehog, and Wnt Signaling Pathways in the Resistance of Tumors to Anticancer Therapies	87
The “Neuro-Glial-Vascular” Unit: The Role of Glia in Neurovascular Unit Formation and Dysfunction	87
Development of Extracellular Vesicle Therapeutics: Challenges, Considerations, and Opportunities	86
The Therapeutic Potential of Mesenchymal Stromal Cells for Regenerative Medicine: Current Knowledge and Future Understandings	85
The Why of YY1: Mechanisms of Transcriptional Regulation by Yin Yang 1	85
Named Entity Recognition and Relation Detection for Biomedical Information Extraction	85
The Current Status of Mesenchymal Stromal Cells: Controversies, Unresolved Issues and Some Promising Solutions to Improve Their Therapeutic Efficacy	84
Mitochondrial Transfer and Regulators of Mesenchymal Stromal Cell Function and Therapeutic Efficacy	84
Targeting Mitochondrial Impairment in Parkinson's Disease: Challenges and Opportunities	84
Signaling Pathways Involved in Diabetic Renal Fibrosis	83
Epithelial-Mesenchymal Transition and Metabolic Switching in Cancer: Lessons From Somatic Cell Reprogramming	83
Role of Wnt Signaling in Adult Hippocampal Neurogenesis in Health and Disease	82
CXCL11 Correlates With Antitumor Immunity and an Improved Prognosis in Colon Cancer	82
Glucose Metabolism and Glucose Transporters in Breast Cancer	82
Mitochondria-Associated ER Membranes – The Origin Site of Autophagy	82
Connective Tissue Growth Factor: From Molecular Understandings to Drug Discovery	81
Development and Validation of a Combined Ferroptosis and Immune Prognostic Classifier for Hepatocellular Carcinoma	81
Blockade of GCH1/BH4 Axis Activates Ferritinophagy to Mitigate the Resistance of Colorectal Cancer to Erastin-Induced Ferroptosis	81
Tissue-Resident Macrophage Development and Function	81
Severity Detection for the Coronavirus Disease 2019 (COVID-19) Patients Using a Machine Learning Model Based on the Blood and Urine Tests	80
Adipogenesis, Osteogenesis, and Chondrogenesis of Human Mesenchymal Stem/Stromal Cells: A Comparative Transcriptome Approach	79
Immunomodulatory Properties of Mesenchymal Stromal Cells: An Update	78
Therapeutic Use of Mesenchymal Stromal Cells: The Need for Inclusive Characterization Guidelines to Accommodate All Tissue Sources and Species	77

Adaptive Mechanisms of Tumor Therapy Resistance Driven by Tumor Microenvironment	77
The Roles of 2-Hydroxyglutarate	76
The Integral Role of RNA in Stress Granule Formation and Function	75
Brain Neurotransmitter Modulation by Gut Microbiota in Anxiety and Depression	75
Role of YAP/TAZ in Cell Lineage Fate Determination and Related Signaling Pathways	75
Cyclin E/CDK2: DNA Replication, Replication Stress and Genomic Instability	75
Evaluating DNA Methylation, Gene Expression, Somatic Mutation, and Their Combinations in Inferring Tumor Tissue-of-Origin	74
Long Non-coding RNAs and MicroRNAs Interplay in Osteogenic Differentiation of Mesenchymal Stem Cells	74
Transmission Routes Analysis of SARS-CoV-2: A Systematic Review and Case Report	73
ORF3a-Mediated Incomplete Autophagy Facilitates Severe Acute Respiratory Syndrome Coronavirus-2 Replication	73
Mitochondria-Associated Endoplasmic Reticulum Membranes in Cardiovascular Diseases	72
TGF-β Signaling and Resistance to Cancer Therapy	72
The Mitochondrial Response to DNA Damage	72
The Role of Tumor-Stroma Interactions in Drug Resistance Within Tumor Microenvironment	71
MicroRNA-34a: Potent Tumor Suppressor, Cancer Stem Cell Inhibitor, and Potential Anticancer Therapeutic	71
Pluripotent Stem Cell Therapies for Parkinson Disease: Present Challenges and Future Opportunities	71
An Eight-CircRNA Assessment Model for Predicting Biochemical Recurrence in Prostate Cancer	71
LRP5 and LRP6 in Wnt Signaling: Similarity and Divergence	71
Subchondral Bone Remodeling: A Therapeutic Target for Osteoarthritis	71
Exosomal miRNA-16-5p Derived From M1 Macrophages Enhances T Cell-Dependent Immune Response by Regulating PD-L1 in Gastric Cancer	71
Exosomes From Adipose-Derived Stem Cells: The Emerging Roles and Applications in Tissue Regeneration of Plastic and Cosmetic Surgery	70
Role of Cholesterol and Lipid Rafts in Cancer Signaling: A Promising Therapeutic Opportunity?	70
B Cell Orchestration of Anti-tumor Immune Responses: A Matter of Cell Localization and Communication	70
Communications Between Bone Marrow Macrophages and Bone Cells in Bone Remodeling	69
Complement Receptors and Their Role in Leukocyte Recruitment and Phagocytosis	69
Targeting Immune Cells in the Tumor Microenvironment of HCC: New Opportunities and Challenges	69
From Flies to Men: ROS and the NADPH Oxidase in Phagocytes	69
Running Against the Wnt: How Wnt/β-Catenin Suppresses Adipogenesis	69
Dissecting the Crosstalk Between Nrf2 and NF-κB Response Pathways in Drug-Induced Toxicity	68
Mesenchymal Stromal Cells as Critical Contributors to Tissue Regeneration	68
The Application of Brain Organoids: From Neuronal Development to Neurological Diseases	68
Two Types of Contact Between Lipid Droplets and Mitochondria	67
Obesity and Bone Health: A Complex Link	66
Mutant p53 Gain-of-Function: Role in Cancer Development, Progression, and Therapeutic Approaches	66
Bone and Muscle Crosstalk in Aging	66
A Guide to Nucleic Acid Vaccines in the Prevention and Treatment of Infectious Diseases and Cancers: From Basic Principles to Current Applications	66
Mesenchymal Stromal Cells and Exosomes: Progress and Challenges	66
Regeneration of Functional Neurons After Spinal Cord Injury via in situ NeuroD1-Mediated Astrocyte-to-Neuron Conversion	66
m6A Regulators Is Differently Expressed and Correlated With Immune Response of Esophageal Cancer	65
New Insights Into Targeting Membrane Lipids for Cancer Therapy	64
Cancer Stem Cells: Emerging Key Players in Immune Evasion of Cancers	63
Is Senescence-Associated β-Galactosidase a Reliable in vivo Marker of Cellular Senescence During Embryonic Development?	63
Quercetin Suppresses Apoptosis and Attenuates Intervertebral Disc Degeneration via the SIRT1-Autophagy Pathway	63
Thyroid Hormones Interaction With Immune Response, Inflammation and Non-thyroidal Illness Syndrome	63
Guidelines for Regulated Cell Death Assays: A Systematic Summary, A Categorical Comparison, A Prospective	63
Cell-Free DNA: Hope and Potential Application in Cancer	63
Primary Cilia, Ciliogenesis and the Actin Cytoskeleton: A Little Less Resorption, A Little More Actin Please	62
Neuron-Oligodendrocyte Interactions in the Structure and Integrity of Axons	62
Modeling Inflammation in Zebrafish for the Development of Anti-inflammatory Drugs	62
Mitochondrial Function and Dysfunction in Dilated Cardiomyopathy	62
Mesenchymal Stem Cell-Macrophage Crosstalk and Maintenance of Inflammatory Microenvironment Homeostasis	62
HGF and MET: From Brain Development to Neurological Disorders	61
Ferroptosis in Acute Central Nervous System Injuries: The Future Direction?	61
Natural Compounds and Autophagy: Allies Against Neurodegeneration	61
A Critical Perspective on 3D Liver Models for Drug Metabolism and Toxicology Studies	61
The Dimensions of Primary Mitochondrial Disorders	60
Prognostic Significance and Tumor Immune Microenvironment Heterogenicity of m5C RNA Methylation Regulators in Triple-Negative Breast Cancer	60
The Role of Gut Microbial β-Glucuronidase in Estrogen Reactivation and Breast Cancer	60
Insights Into the Role of CircRNAs: Biogenesis, Characterization, Functional, and Clinical Impact in Human Malignancies	60
USP7 Is a Master Regulator of Genome Stability	60
The Role of Short-Chain Fatty Acids and Bile Acids in Intestinal and Liver Function, Inflammation, and Carcinogenesis	60
CircRNA Is a Rising Star in Researches of Ocular Diseases	59
New Understanding of the Relevant Role of LINE-1 Retrotransposition in Human Disease and Immune Modulation	59
Mechanisms of Oocyte Maturation and Related Epigenetic Regulation	59
Endothelial-to-Mesenchymal Transition in Cancer	59
N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and Applications	59
Cadmium-Induced Cytotoxicity: Effects on Mitochondrial Electron Transport Chain	59
Extracellular Vesicles Derived From Apoptotic Cells: An Essential Link Between Death and Regeneration	58
Mitochondrial OMA1 and OPA1 as Gatekeepers of Organellar Structure/Function and Cellular Stress Response	58
Mesenchymal Stem Cells Adaptively Respond to Environmental Cues Thereby Improving Granulation Tissue Formation and Wound Healing	58
STING1 Promotes Ferroptosis Through MFN1/2-Dependent Mitochondrial Fusion	58
Liraglutide Alleviates Hepatic Steatosis by Activating the TFEB-Regulated Autophagy-Lysosomal Pathway	58
Mitochondrial Dynamics in Adult Cardiomyocytes and Heart Diseases	58
Emerging Roles of Exosomal Circular RNAs in Cancer	58
Identifying Transcriptomic Signatures and Rules for SARS-CoV-2 Infection	58
In vivo Neuroregeneration to Treat Ischemic Stroke Through NeuroD1 AAV-Based Gene Therapy in Adult Non-human Primates	58
Exosomal PD-L1: New Insights Into Tumor Immune Escape Mechanisms and Therapeutic Strategies	57
Fusobacterium nucleatum Acts as a Pro-carcinogenic Bacterium in Colorectal Cancer: From Association to Causality	57
The MicroRNA Family Gets Wider: The IsomiRs Classification and Role	57
Telomere Replication: Solving Multiple End Replication Problems	57

A Novel Ten-Gene Signature Predicting Prognosis in Hepatocellular Carcinoma	57
Inflammation and Wnt Signaling: Target for Immunomodulatory Therapy?	56
COVID-19 and the Vasculature: Current Aspects and Long-Term Consequences	56
The Role of Proteoglycans in Cancer Metastasis and Circulating Tumor Cell Analysis	56
CD226: An Emerging Role in Immunologic Diseases	56
Molecular Mechanisms of Chondrocyte Proliferation and Differentiation	56
The Nrf2 Pathway in Liver Diseases	56
Fibroblast Senescence in Idiopathic Pulmonary Fibrosis	55
Biophysical and Biochemical Cues of Biomaterials Guide Mesenchymal Stem Cell Behaviors	55
Modeling Rett Syndrome With Human Patient-Specific Forebrain Organoids	55
Identification of CDK2-Related Immune Forecast Model and ceRNA in Lung Adenocarcinoma, a Pan-Cancer Analysis	55
Connecting the Dots: Resolving the Bone Marrow Niche Heterogeneity	55
Mesenchymal Stromal Cell-Produced Components of Extracellular Matrix Potentiate Multipotent Stem Cell Response to Differentiation Stimuli	55
Ion Transport in Eryptosis, the Suicidal Death of Erythrocytes	54
Genetic Engineering as a Strategy to Improve the Therapeutic Efficacy of Mesenchymal Stem/Stromal Cells in Regenerative Medicine	54
Regulation of Myostatin on the Growth and Development of Skeletal Muscle	54
The Role of Astrocytes in the Neurorepair Process	54
m6A Methylation Regulates Osteoblastic Differentiation and Bone Remodeling	54
Comparative Genomics of Peroxisome Biogenesis Proteins: Making Sense of the PEX Proteins	54
The Multifaceted Roles of Proline in Cell Behavior	54
Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development	53
Development and Validation of a Robust Ferroptosis-Related Prognostic Signature in Lung Adenocarcinoma	53
Roles of N6-Methyladenosine (m6A) in Stem Cell Fate Decisions and Early Embryonic Development in Mammals	53
Vertebrate Sensory Ganglia: Common and Divergent Features of the Transcriptional Programs Generating Their Functional Specialization	53
Niches for Skeletal Stem Cells of Mesenchymal Origin	53
Global Research Trends of Ferroptosis: A Rapidly Evolving Field With Enormous Potential	53
Neurovascular Coupling in Development and Disease: Focus on Astrocytes	53
Mitochondria Donation by Mesenchymal Stem Cells: Current Understanding and Mitochondria Transplantation Strategies	53
Nerves in the Tumor Microenvironment: Origin and Effects	53
Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Lung Diseases: Current Status and Perspectives	53
LncRNA KCNQ1OT1 Secreted by Tumor Cell-Derived Exosomes Mediates Immune Escape in Colorectal Cancer by Regulating PD-L1 Ubiquitination via MiR-30a-5p/USP22	52
Mitochondrial Protein Translation: Emerging Roles and Clinical Significance in Disease	52
A Prognostic Ferroptosis-Related lncRNAs Signature Associated With Immune Landscape and Radiotherapy Response in Glioma	52
Identification and Validation of Pyroptosis-Related Gene Signature to Predict Prognosis and Reveal Immune Infiltration in Hepatocellular Carcinoma	52
Citicoline Protects Auditory Hair Cells Against Neomycin-Induced Damage	52
Membrane-Interacting Antifungal Peptides	52
Recent Update of HDAC Inhibitors in Lymphoma	52
Cardiomyocyte Proliferation and Maturation: Two Sides of the Same Coin for Heart Regeneration	52
The Roles of Epigenetics Regulation in Bone Metabolism and Osteoporosis	52
The Paradoxical Role of Cellular Senescence in Cancer	52
nCOVID-19 Pandemic: From Molecular Pathogenesis to Potential Investigational Therapeutics	52
Insights on SARS-CoV-2 Molecular Interactions With the Renin-Angiotensin System	51
Expression of m6A Regulators Correlated With Immune Microenvironment Predicts Therapeutic Efficacy and Prognosis in Gliomas	51
MicroRNA-221/222 Mediates ADSC-Exosome-Induced Cardioprotection Against Ischemia/Reperfusion by Targeting PUMA and ETS-1	51
From Donor to the Lab: A Fascinating Journey of Primary Cell Lines	51
Toll-Like Receptors as a Therapeutic Target in the Era of Immunotherapies	51
Heterochromatin as an Important Driver of Genome Organization	51
Autophagy, Pyroptosis, and Ferroptosis: New Regulatory Mechanisms for Atherosclerosis	51
Emerging Roles of Liquid–Liquid Phase Separation in Cancer: From Protein Aggregation to Immune-Associated Signaling	51
Characterization of the Zebrafish Cell Landscape at Single-Cell Resolution	51
Molecular Crosstalk Between MYC and HIF in Cancer	51
Regulation of Wnt Signaling Pathways at the Plasma Membrane and Their Misregulation in Cancer	51
Reactive Oxygen Species: Not Omnipresent but Important in Many Locations	50
Determinants and Functions of CAFs Secretome During Cancer Progression and Therapy	50
Neural Stem Cells and Methods for Their Generation From Induced Pluripotent Stem Cells in vitro	50
Exosome-Based Delivery of Natural Products in Cancer Therapy	50
Lipid Droplet-Organelle Contact Sites as Hubs for Fatty Acid Metabolism, Trafficking, and Metabolic Channeling	50
Gastric Stem Cells: Physiological and Pathological Perspectives	50
Ferroptosis: A Novel Therapeutic Target for Ischemia-Reperfusion Injury	49
Bone Marrow Mesenchymal Stromal Cells: Identification, Classification, and Differentiation	49
Receptor Oligomerization and Its Relevance for Signaling by Receptors of the Tumor Necrosis Factor Receptor Superfamily	49
Age-Related Macular Degeneration Revisited: From Pathology and Cellular Stress to Potential Therapies	49
The Function of Astrocyte Mediated Extracellular Vesicles in Central Nervous System Diseases	49
Integrating the Hallmarks of Aging Throughout the Tree of Life: A Focus on Mitochondrial Dysfunction	49
Periodontal Inflammation-Triggered by Periodontal Ligament Stem Cell Pyroptosis Exacerbates Periodontitis	48
Role of Small Molecule Targeted Compounds in Cancer: Progress, Opportunities, and Challenges	48
Tumor Associated Macrophages, as the Dominant Immune Cells, Are an Indispensable Target for Immunologically Cold Tumor—Glioma Therapy?	48
Premyelinating Oligodendrocytes: Mechanisms Underlying Cell Survival and Integration	48
Hypoxia-Inducible Factor (HIF) in Ischemic Stroke and Neurodegenerative Disease	48
Neural Stem Cell-Derived Exosomes Regulate Neural Stem Cell Differentiation Through miR-9-Hes1 Axis	48
Biological Properties of Milk-Derived Extracellular Vesicles and Their Physiological Functions in Infant	48
Emerging Exosomes and Exosomal MiRNAs in Spinal Cord Injury	48
A Novel Mechanism of Cannabidiol in Suppressing Hepatocellular Carcinoma by Inducing GSDME Dependent Pyroptosis	48
From Sperm Motility to Sperm-Borne microRNA Signatures: New Approaches to Predict Male Fertility Potential	47
Brain Ultrastructure: Putting the Pieces Together	47
Functional Versatility of the CDK Inhibitor p57Kip2	47
Non-syndromic Cleft Palate: An Overview on Human Genetic and Environmental Risk Factors	47
Sensing R-Loop-Associated DNA Damage to Safeguard Genome Stability	47
MiT/TFE Family of Transcription Factors: An Evolutionary Perspective	47
piRNA-823 Is Involved in Cancer Stem Cell Regulation Through Altering DNA Methylation in Association With Luminal Breast Cancer	47
ARF GTPases and Their Ubiquitous Role in Intracellular Trafficking Beyond the Golgi	47
Exosomal miR-128-3p Promotes Epithelial-to-Mesenchymal Transition in Colorectal Cancer Cells by Targeting FOXO4 via TGF-β/SMAD and JAK/STAT3 Signaling	47
Prognostic Nutritional Index (PNI) in Patients With Breast Cancer Treated With Neoadjuvant Chemotherapy as a Useful Prognostic Indicator	47
Roles of Aminoacyl-tRNA Synthetases in Cancer	46
Lysosomes and Cancer Progression: A Malignant Liaison	46
Preventing Mortality in COVID-19 Patients: Which Cytokine to Target in a Raging Storm?	46
The Regulation and Function of Histone Crotonylation	46
Understanding the Impact of Uterine Fibroids on Human Endometrium Function	46
Histone Deacetylase Inhibition in Non-small Cell Lung Cancer: Hype or Hope?	46
Understanding the Multiple Role of Mitochondria in Parkinson’s Disease and Related Disorders: Lesson From Genetics and Protein–Interaction Network	46
Anti-tumor Effect of Oleic Acid in Hepatocellular Carcinoma Cell Lines via Autophagy Reduction	46
Notch Signalling in Breast Development and Cancer	46
Understanding the Role of the Gut Microbiome in Brain Development and Its Association With Neurodevelopmental Psychiatric Disorders	46
Recent Advances in the Controlled Release of Growth Factors and Cytokines for Improving Cutaneous Wound Healing	46
Metabolism and Innate Immunity Meet at the Mitochondria	46