Frontiers in Cell and Developmental Biology

Article	Citations
Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype	773
Beneficial and Detrimental Effects of Reactive Oxygen Species on Lifespan: A Comprehensive Review of Comparative and Experimental Studies	260
Characteristics and Biomarkers of Ferroptosis	238
Metabolism of Amino Acids in Cancer	199
Molecular Bases of VEGFR-2-Mediated Physiological Function and Pathological Role	161
The mTOR–Autophagy Axis and the Control of Metabolism	160
Premature Ovarian Insufficiency: Past, Present, and Future	152
Comparative Analysis of BTK Inhibitors and Mechanisms Underlying Adverse Effects	140
Exosomes, a New Star for Targeted Delivery	140
Physiological Signaling Functions of Reactive Oxygen Species in Stem Cells: From Flies to Man	130
The Pyroptosis-Related Signature Predicts Prognosis and Indicates Immune Microenvironment Infiltration in Gastric Cancer	129
Mechanoregulation of YAP and TAZ in Cellular Homeostasis and Disease Progression	128
The Role of Exosomes and Exosomal MicroRNA in Cardiovascular Disease	126
Selective Autophagy Receptor p62/SQSTM1, a Pivotal Player in Stress and Aging	125
Recent Advances of Osterix Transcription Factor in Osteoblast Differentiation and Bone Formation	125
The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines	123
The Ageing Brain: Molecular and Cellular Basis of Neurodegeneration	121
Liver Fibrosis: Therapeutic Targets and Advances in Drug Therapy	117
Targeting Cell Death: Pyroptosis, Ferroptosis, Apoptosis and Necroptosis in Osteoarthritis	115
Bearing My Heart: The Role of Extracellular Matrix on Cardiac Development, Homeostasis, and Injury Response	112
Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma: Origin, Polarization, Function, and Reprogramming	112
BMSC-Derived Exosomal miR-29a Promotes Angiogenesis and Osteogenesis	110
The Role of Autophagy in Osteoarthritis	107
Recent Trends in the Development of Bone Regenerative Biomaterials	107
The Extracellular Matrix in Skin Inflammation and Infection	106

Regulatory Mechanisms of Vitellogenesis in Insects	104
The Role of Notch, Hedgehog, and Wnt Signaling Pathways in the Resistance of Tumors to Anticancer Therapies	102
Notch Signaling in Vascular Endothelial Cells, Angiogenesis, and Tumor Progression: An Update and Prospective	101
Roles of Macrophages in the Development and Treatment of Gut Inflammation	101
Epigenetics of Male Infertility: The Role of DNA Methylation	101
Structural and Functional Dysbiosis of Fecal Microbiota in Chinese Patients With Alzheimer's Disease	100
Development of Extracellular Vesicle Therapeutics: Challenges, Considerations, and Opportunities	98
Biological Function of Long Non-coding RNA (LncRNA) Xist	97
The Therapeutic Potential of Mesenchymal Stromal Cells for Regenerative Medicine: Current Knowledge and Future Understandings	97
The “Neuro-Glial-Vascular” Unit: The Role of Glia in Neurovascular Unit Formation and Dysfunction	96
Cancer-Associated Fibroblast (CAF) Heterogeneity and Targeting Therapy of CAFs in Pancreatic Cancer	96
Deciphering Epitranscriptome: Modification of mRNA Bases Provides a New Perspective for Post-transcriptional Regulation of Gene Expression	96
Blockade of GCH1/BH4 Axis Activates Ferritinophagy to Mitigate the Resistance of Colorectal Cancer to Erastin-Induced Ferroptosis	94
The Epithelial-to-Mesenchymal Transition as a Possible Therapeutic Target in Fibrotic Disorders	92
Mitochondrial Transfer and Regulators of Mesenchymal Stromal Cell Function and Therapeutic Efficacy	92
Scalable Production of Human Mesenchymal Stromal Cell-Derived Extracellular Vesicles Under Serum-/Xeno-Free Conditions in a Microcarrier-Based Bioreactor Culture System	90
Signaling Pathways Involved in Diabetic Renal Fibrosis	89
CXCL11 Correlates With Antitumor Immunity and an Improved Prognosis in Colon Cancer	88
Dissecting the Crosstalk Between Nrf2 and NF-κB Response Pathways in Drug-Induced Toxicity	88
Immunomodulatory Properties of Mesenchymal Stromal Cells: An Update	88
The Roles of 2-Hydroxyglutarate	87
Targeting Mitochondrial Impairment in Parkinson's Disease: Challenges and Opportunities	87
Glucose Metabolism and Glucose Transporters in Breast Cancer	87
The Current Status of Mesenchymal Stromal Cells: Controversies, Unresolved Issues and Some Promising Solutions to Improve Their Therapeutic Efficacy	85
Tissue-Resident Macrophage Development and Function	84
Therapeutic Use of Mesenchymal Stromal Cells: The Need for Inclusive Characterization Guidelines to Accommodate All Tissue Sources and Species	84
Adaptive Mechanisms of Tumor Therapy Resistance Driven by Tumor Microenvironment	83
Development and Validation of a Combined Ferroptosis and Immune Prognostic Classifier for Hepatocellular Carcinoma	82
LRP5 and LRP6 in Wnt Signaling: Similarity and Divergence	82
The Integral Role of RNA in Stress Granule Formation and Function	82
Cyclin E/CDK2: DNA Replication, Replication Stress and Genomic Instability	82
The Role of Tumor-Stroma Interactions in Drug Resistance Within Tumor Microenvironment	80
Mitochondria-Associated Endoplasmic Reticulum Membranes in Cardiovascular Diseases	80
TGF-β Signaling and Resistance to Cancer Therapy	79
The Mitochondrial Response to DNA Damage	79
An Eight-CircRNA Assessment Model for Predicting Biochemical Recurrence in Prostate Cancer	77
B Cell Orchestration of Anti-tumor Immune Responses: A Matter of Cell Localization and Communication	77
From Flies to Men: ROS and the NADPH Oxidase in Phagocytes	77
ORF3a-Mediated Incomplete Autophagy Facilitates Severe Acute Respiratory Syndrome Coronavirus-2 Replication	77
Long Non-coding RNAs and MicroRNAs Interplay in Osteogenic Differentiation of Mesenchymal Stem Cells	76
Evaluating DNA Methylation, Gene Expression, Somatic Mutation, and Their Combinations in Inferring Tumor Tissue-of-Origin	76
Brain Neurotransmitter Modulation by Gut Microbiota in Anxiety and Depression	76
Complement Receptors and Their Role in Leukocyte Recruitment and Phagocytosis	75
Communications Between Bone Marrow Macrophages and Bone Cells in Bone Remodeling	75
Subchondral Bone Remodeling: A Therapeutic Target for Osteoarthritis	75
Exosomal miRNA-16-5p Derived From M1 Macrophages Enhances T Cell-Dependent Immune Response by Regulating PD-L1 in Gastric Cancer	75
Role of Cholesterol and Lipid Rafts in Cancer Signaling: A Promising Therapeutic Opportunity?	75
Targeting Immune Cells in the Tumor Microenvironment of HCC: New Opportunities and Challenges	75
Bone and Muscle Crosstalk in Aging	74
Running Against the Wnt: How Wnt/β-Catenin Suppresses Adipogenesis	74

MicroRNA-34a: Potent Tumor Suppressor, Cancer Stem Cell Inhibitor, and Potential Anticancer Therapeutic	73
A Guide to Nucleic Acid Vaccines in the Prevention and Treatment of Infectious Diseases and Cancers: From Basic Principles to Current Applications	72
Two Types of Contact Between Lipid Droplets and Mitochondria	71
Regeneration of Functional Neurons After Spinal Cord Injury via in situ NeuroD1-Mediated Astrocyte-to-Neuron Conversion	71
Mutant p53 Gain-of-Function: Role in Cancer Development, Progression, and Therapeutic Approaches	70
Mesenchymal Stem Cell-Macrophage Crosstalk and Maintenance of Inflammatory Microenvironment Homeostasis	69
Mitochondrial Function and Dysfunction in Dilated Cardiomyopathy	69
Neuron-Oligodendrocyte Interactions in the Structure and Integrity of Axons	68
Obesity and Bone Health: A Complex Link	68
m6A Regulators Is Differently Expressed and Correlated With Immune Response of Esophageal Cancer	67
Cancer Stem Cells: Emerging Key Players in Immune Evasion of Cancers	67
Modeling Inflammation in Zebrafish for the Development of Anti-inflammatory Drugs	67
HGF and MET: From Brain Development to Neurological Disorders	67
Identification of CDK2-Related Immune Forecast Model and ceRNA in Lung Adenocarcinoma, a Pan-Cancer Analysis	67
A Critical Perspective on 3D Liver Models for Drug Metabolism and Toxicology Studies	67
Mitochondrial OMA1 and OPA1 as Gatekeepers of Organellar Structure/Function and Cellular Stress Response	66
The Role of Short-Chain Fatty Acids and Bile Acids in Intestinal and Liver Function, Inflammation, and Carcinogenesis	66
Liraglutide Alleviates Hepatic Steatosis by Activating the TFEB-Regulated Autophagy-Lysosomal Pathway	66
Is Senescence-Associated β-Galactosidase a Reliable in vivo Marker of Cellular Senescence During Embryonic Development?	66
The Role of Gut Microbial β-Glucuronidase in Estrogen Reactivation and Breast Cancer	66
Mechanisms of Oocyte Maturation and Related Epigenetic Regulation	65
Cell-Free DNA: Hope and Potential Application in Cancer	65
Primary Cilia, Ciliogenesis and the Actin Cytoskeleton: A Little Less Resorption, A Little More Actin Please	65
Molecular Mechanisms of Chondrocyte Proliferation and Differentiation	65
Cadmium-Induced Cytotoxicity: Effects on Mitochondrial Electron Transport Chain	65
Quercetin Suppresses Apoptosis and Attenuates Intervertebral Disc Degeneration via the SIRT1-Autophagy Pathway	64
Telomere Replication: Solving Multiple End Replication Problems	64
N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and Applications	63
Insights Into the Role of CircRNAs: Biogenesis, Characterization, Functional, and Clinical Impact in Human Malignancies	63
Fusobacterium nucleatum Acts as a Pro-carcinogenic Bacterium in Colorectal Cancer: From Association to Causality	63
STING1 Promotes Ferroptosis Through MFN1/2-Dependent Mitochondrial Fusion	63
Guidelines for Regulated Cell Death Assays: A Systematic Summary, A Categorical Comparison, A Prospective	63
The Dimensions of Primary Mitochondrial Disorders	63
Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development	63
COVID-19 and the Vasculature: Current Aspects and Long-Term Consequences	63
Mitochondrial Dynamics in Adult Cardiomyocytes and Heart Diseases	63
The Role of Astrocytes in the Neurorepair Process	62
Understanding the Role of the Gut Microbiome in Brain Development and Its Association With Neurodevelopmental Psychiatric Disorders	62
The MicroRNA Family Gets Wider: The IsomiRs Classification and Role	62
m6A Methylation Regulates Osteoblastic Differentiation and Bone Remodeling	62
In vivo Neuroregeneration to Treat Ischemic Stroke Through NeuroD1 AAV-Based Gene Therapy in Adult Non-human Primates	61
The Nrf2 Pathway in Liver Diseases	61
Regulation of Myostatin on the Growth and Development of Skeletal Muscle	61
Prognostic Significance and Tumor Immune Microenvironment Heterogenicity of m5C RNA Methylation Regulators in Triple-Negative Breast Cancer	60
Modeling Rett Syndrome With Human Patient-Specific Forebrain Organoids	60
Connecting the Dots: Resolving the Bone Marrow Niche Heterogeneity	60
Biophysical and Biochemical Cues of Biomaterials Guide Mesenchymal Stem Cell Behaviors	60
Membrane-Interacting Antifungal Peptides	60
The Multifaceted Roles of Proline in Cell Behavior	60
Inflammation and Wnt Signaling: Target for Immunomodulatory Therapy?	60
Identifying Transcriptomic Signatures and Rules for SARS-CoV-2 Infection	60
Thyroid Hormones Interaction With Immune Response, Inflammation and Non-thyroidal Illness Syndrome	60
Comparative Genomics of Peroxisome Biogenesis Proteins: Making Sense of the PEX Proteins	59
From Donor to the Lab: A Fascinating Journey of Primary Cell Lines	59
Toll-Like Receptors as a Therapeutic Target in the Era of Immunotherapies	59
Fibroblast Senescence in Idiopathic Pulmonary Fibrosis	59
Characterization of the Zebrafish Cell Landscape at Single-Cell Resolution	58
Nerves in the Tumor Microenvironment: Origin and Effects	58
Bone Marrow Mesenchymal Stromal Cells: Identification, Classification, and Differentiation	58
Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Lung Diseases: Current Status and Perspectives	57
Autophagy, Pyroptosis, and Ferroptosis: New Regulatory Mechanisms for Atherosclerosis	57
Mitochondria Donation by Mesenchymal Stem Cells: Current Understanding and Mitochondria Transplantation Strategies	57
Determinants and Functions of CAFs Secretome During Cancer Progression and Therapy	57
Lipid Droplet-Organelle Contact Sites as Hubs for Fatty Acid Metabolism, Trafficking, and Metabolic Channeling	56
MicroRNA-221/222 Mediates ADSC-Exosome-Induced Cardioprotection Against Ischemia/Reperfusion by Targeting PUMA and ETS-1	56
Morphogenesis, Growth Cycle and Molecular Regulation of Hair Follicles	56
Exosome-Based Delivery of Natural Products in Cancer Therapy	56
Neurovascular Coupling in Development and Disease: Focus on Astrocytes	56
Ferroptosis: A Novel Therapeutic Target for Ischemia-Reperfusion Injury	55
Global Research Trends of Ferroptosis: A Rapidly Evolving Field With Enormous Potential	55
The Paradoxical Role of Cellular Senescence in Cancer	55
Identification and Validation of Pyroptosis-Related Gene Signature to Predict Prognosis and Reveal Immune Infiltration in Hepatocellular Carcinoma	55
Mitochondrial Protein Translation: Emerging Roles and Clinical Significance in Disease	55
A Prognostic Ferroptosis-Related lncRNAs Signature Associated With Immune Landscape and Radiotherapy Response in Glioma	55
Molecular Crosstalk Between MYC and HIF in Cancer	55
The Roles of Epigenetics Regulation in Bone Metabolism and Osteoporosis	55
PGC-1α-Mediated Mitochondrial Quality Control: Molecular Mechanisms and Implications for Heart Failure	54
Receptor Oligomerization and Its Relevance for Signaling by Receptors of the Tumor Necrosis Factor Receptor Superfamily	54
Lysosomes and Cancer Progression: A Malignant Liaison	54
Biological Features of Extracellular Vesicles and Challenges	54

Emerging Exosomes and Exosomal MiRNAs in Spinal Cord Injury	54
Development and Validation of a Robust Ferroptosis-Related Prognostic Signature in Lung Adenocarcinoma	54
Periodontal Inflammation-Triggered by Periodontal Ligament Stem Cell Pyroptosis Exacerbates Periodontitis	54
Hypoxia-Inducible Factor (HIF) in Ischemic Stroke and Neurodegenerative Disease	53
Role of Small Molecule Targeted Compounds in Cancer: Progress, Opportunities, and Challenges	53
Emerging Roles of Liquid–Liquid Phase Separation in Cancer: From Protein Aggregation to Immune-Associated Signaling	53
Regulation of Wnt Signaling Pathways at the Plasma Membrane and Their Misregulation in Cancer	53
Tumor Associated Macrophages, as the Dominant Immune Cells, Are an Indispensable Target for Immunologically Cold Tumor—Glioma Therapy?	53
LncRNA KCNQ1OT1 Secreted by Tumor Cell-Derived Exosomes Mediates Immune Escape in Colorectal Cancer by Regulating PD-L1 Ubiquitination via MiR-30a-5p/USP22	52
Neural Stem Cell-Derived Exosomes Regulate Neural Stem Cell Differentiation Through miR-9-Hes1 Axis	52
Efferocytosis and Its Role in Inflammatory Disorders	52
Expression of m6A Regulators Correlated With Immune Microenvironment Predicts Therapeutic Efficacy and Prognosis in Gliomas	52
Ferroptosis Signaling and Regulators in Atherosclerosis	52
Prognostic Nutritional Index (PNI) in Patients With Breast Cancer Treated With Neoadjuvant Chemotherapy as a Useful Prognostic Indicator	52
ARF GTPases and Their Ubiquitous Role in Intracellular Trafficking Beyond the Golgi	52
Possible Mechanisms of Tau Spread and Toxicity in Alzheimer’s Disease	52
Integrating the Hallmarks of Aging Throughout the Tree of Life: A Focus on Mitochondrial Dysfunction	52
Premyelinating Oligodendrocytes: Mechanisms Underlying Cell Survival and Integration	52
Dental-Derived Mesenchymal Stem Cells: State of the Art	51
The Regulation and Function of Histone Crotonylation	51
Age-Related Macular Degeneration Revisited: From Pathology and Cellular Stress to Potential Therapies	51
Anti-tumor Effect of Oleic Acid in Hepatocellular Carcinoma Cell Lines via Autophagy Reduction	51
Reactive Oxygen Species: Not Omnipresent but Important in Many Locations	51
Brain Ultrastructure: Putting the Pieces Together	50
RETRACTED: Exosomal miR-128-3p Promotes Epithelial-to-Mesenchymal Transition in Colorectal Cancer Cells by Targeting FOXO4 via TGF-β/SMAD and JAK/STAT3 Signaling	50
Notch Signalling in Breast Development and Cancer	50
A Novel Mechanism of Cannabidiol in Suppressing Hepatocellular Carcinoma by Inducing GSDME Dependent Pyroptosis	50
The Cellular Origins of Cancer-Associated Fibroblasts and Their Opposing Contributions to Pancreatic Cancer Growth	50
Perlecan, A Multi-Functional, Cell-Instructive, Matrix-Stabilizing Proteoglycan With Roles in Tissue Development Has Relevance to Connective Tissue Repair and Regeneration	50
piRNA-823 Is Involved in Cancer Stem Cell Regulation Through Altering DNA Methylation in Association With Luminal Breast Cancer	49
The Gut Microbiota, Kynurenine Pathway, and Immune System Interaction in the Development of Brain Cancer	49
MiT/TFE Family of Transcription Factors: An Evolutionary Perspective	49
N6-Methyladenosine Methyltransferase METTL3 Promotes Angiogenesis and Atherosclerosis by Upregulating the JAK2/STAT3 Pathway via m6A Reader IGF2BP1	49
Fundamental Mechanisms of the Cell Death Caused by Nitrosative Stress	49
Native and Bioengineered Exosomes for Ischemic Stroke Therapy	49
The m6A Reader YTHDF1 Facilitates the Tumorigenesis and Metastasis of Gastric Cancer via USP14 Translation in an m6A-Dependent Manner	49
A Promising Future of Ferroptosis in Tumor Therapy	49
Sensing R-Loop-Associated DNA Damage to Safeguard Genome Stability	49
Understanding the Impact of Uterine Fibroids on Human Endometrium Function	49
Biological Properties of Milk-Derived Extracellular Vesicles and Their Physiological Functions in Infant	49
Understanding the Multiple Role of Mitochondria in Parkinson’s Disease and Related Disorders: Lesson From Genetics and Protein–Interaction Network	49
The Structural Biology of Septins and Their Filaments: An Update	49
Chromosome Organization in Early Meiotic Prophase	49
The Elusive Endometrial Epithelial Stem/Progenitor Cells	49
Metabolism and Innate Immunity Meet at the Mitochondria	48
Targeting Integrins for Cancer Therapy - Disappointments and Opportunities	48
Mitophagy in Diabetic Cardiomyopathy: Roles and Mechanisms	48
Intrinsic Mechanical Cues and Their Impact on Stem Cells and Embryogenesis	47
A Different Facet of p53 Function: Regulation of Immunity and Inflammation During Tumor Development	47
Rab GTPases: Central Coordinators of Membrane Trafficking in Cancer	47
How Malaria Parasites Acquire Nutrients From Their Host	47
Mitophagy Receptors in Tumor Biology	47
Roles of Aminoacyl-tRNA Synthetases in Cancer	47
The Emerging Mechanisms of Wnt Secretion and Signaling in Development	47
Pre-metastatic Niche Formation in Different Organs Induced by Tumor Extracellular Vesicles	47
ROS induced lipid peroxidation and their role in ferroptosis	47
GABAergic System Dysfunction in Autism Spectrum Disorders	47
Molecular Classification of Knee Osteoarthritis	47
Two Decades of Global Progress in Authorized Advanced Therapy Medicinal Products: An Emerging Revolution in Therapeutic Strategies	47
Ferroptosis and Its Potential Role in Metabolic Diseases: A Curse or Revitalization?	46
Targeting Lipid Rafts as a Strategy Against Coronavirus	46
Effect of 2D and 3D Culture Microenvironments on Mesenchymal Stem Cell-Derived Extracellular Vesicles Potencies	46
The Inflammasome Contributes to Depletion of the Ovarian Reserve During Aging in Mice	46
The Role of Impaired Mitochondrial Dynamics in MFN2-Mediated Pathology	46
Ezrin Mediates Invasion and Metastasis in Tumorigenesis: A Review	46
TRIM26 Induces Ferroptosis to Inhibit Hepatic Stellate Cell Activation and Mitigate Liver Fibrosis Through Mediating SLC7A11 Ubiquitination	46
Ferroptosis, a Potential Therapeutic Target in Alzheimer’s Disease	46
Overcoming Cancer Drug Resistance Utilizing PROTAC Technology	46
Sensing and Responding of Cardiomyocytes to Changes of Tissue Stiffness in the Diseased Heart	46
Biological Significance of NOTCH Signaling Strength	46
Multinucleated Giant Cells: Current Insights in Phenotype, Biological Activities, and Mechanism of Formation	46
Meiotic Crossover Patterning	45
Mitochondrial Dysfunction: Cause or Consequence of Vascular Calcification?	45
Identification of the Role and Clinical Prognostic Value of Target Genes of m6A RNA Methylation Regulators in Glioma	45
Atorvastatin Induces Mitochondria-Dependent Ferroptosis via the Modulation of Nrf2-xCT/GPx4 Axis	45
Molecular Basis for CCRL2 Regulation of Leukocyte Migration	45
Skeletal muscle oxidative stress and inflammation in aging: Focus on antioxidant and anti-inflammatory therapy	45
Voltage-Gated Potassium Channels as Regulators of Cell Death	45
Serum Metabolomics Study of Papillary Thyroid Carcinoma Based on HPLC-Q-TOF-MS/MS	45
Functional and Pathological Roles of AHCY	45
Expression of Lipid-Metabolism Genes Is Correlated With Immune Microenvironment and Predicts Prognosis in Osteosarcoma	45
The Emerging Roles of Pericytes in Modulating Tumor Microenvironment	45
The Endothelial Glycocalyx as a Double-Edged Sword in Microvascular Homeostasis and Pathogenesis	45
The Multifunctional Contribution of FGF Signaling to Cardiac Development, Homeostasis, Disease and Repair	45
Recent Progress of Ferroptosis in Lung Diseases	45
Mitochondria Related Cell Death Modalities and Disease	44
Roles of Non-coding RNAs and Angiogenesis in Glioblastoma	44
Exosomes as Drug Carriers in Anti-Cancer Therapy	44
A Comparative Overview of Epigenomic Profiling Methods	44
Functions of Oxysterol-Binding Proteins at Membrane Contact Sites and Their Control by Phosphoinositide Metabolism	44
Folliculin: A Regulator of Transcription Through AMPK and mTOR Signaling Pathways	44
Energy and Dynamics of Caveolae Trafficking	44
GSDMD Mediates LPS-Induced Septic Myocardial Dysfunction by Regulating ROS-dependent NLRP3 Inflammasome Activation	44
Extracellular RNA as a Versatile DAMP and Alarm Signal That Influences Leukocyte Recruitment in Inflammation and Infection	44
Mechanism and Control of Meiotic DNA Double-Strand Break Formation in S. cerevisiae	44