Frontiers in Cell and Developmental Biology

(The median citation count of Frontiers in Cell and Developmental Biology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 500 papers]. The publications cover those that have been published in the past four years, i.e., from 2019-09-01 to 2023-09-01.)
Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype427
Iron Metabolism in Ferroptosis288
Mitophagy, Mitochondrial Homeostasis, and Cell Fate243
PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor Resistance243
Oxidative Damage and Antioxidant Defense in Ferroptosis190
T Cell Dysfunction and Exhaustion in Cancer173
Mitophagy: An Emerging Role in Aging and Age-Associated Diseases171
Mesenchymal Stem Cell-Derived Extracellular Vesicles: Challenges in Clinical Applications168
Molecular Mechanisms of Radiation-Induced Cancer Cell Death: A Primer165
MicroRNAs: From Mechanism to Organism162
Characteristics and Biomarkers of Ferroptosis152
Resistance Mechanisms of Anti-PD1/PDL1 Therapy in Solid Tumors147
Beneficial and Detrimental Effects of Reactive Oxygen Species on Lifespan: A Comprehensive Review of Comparative and Experimental Studies141
Metabolism of Amino Acids in Cancer138
In vitro Models of Neurodegenerative Diseases128
FGF Signaling Pathway: A Key Regulator of Stem Cell Pluripotency128
Diversity and Emerging Roles of Enhancer RNA in Regulation of Gene Expression and Cell Fate123
Adult Stem Cells for Bone Regeneration and Repair120
The Keloid Disorder: Heterogeneity, Histopathology, Mechanisms and Models116
TGF-β-Induced Endothelial to Mesenchymal Transition in Disease and Tissue Engineering116
Senescence in Mesenchymal Stem Cells: Functional Alterations, Molecular Mechanisms, and Rejuvenation Strategies116
Energy Metabolism Regulates Stem Cell Pluripotency115
A Revised Perspective of Skeletal Stem Cell Biology110
A Brief Review of Current Maturation Methods for Human Induced Pluripotent Stem Cells-Derived Cardiomyocytes110
On-Target Anti-TGF-β Therapies Are Not Succeeding in Clinical Cancer Treatments: What Are Remaining Challenges?110
Diverse Role of TGF-β in Kidney Disease108
The Balance of TNF Mediated Pathways Regulates Inflammatory Cell Death Signaling in Healthy and Diseased Tissues108
Selective Targeting of TNF Receptors as a Novel Therapeutic Approach107
The Emerging Role of the Mammalian Glycocalyx in Functional Membrane Organization and Immune System Regulation105
The Pyroptosis-Related Signature Predicts Prognosis and Indicates Immune Microenvironment Infiltration in Gastric Cancer104
N6-Methylandenosine-Related lncRNAs Are Potential Biomarkers for Predicting the Overall Survival of Lower-Grade Glioma Patients103
The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy101
Laboratory Testing Methods for Novel Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2)93
The Impact of PM2.5 on the Host Defense of Respiratory System93
Comparative Analysis of BTK Inhibitors and Mechanisms Underlying Adverse Effects93
Molecular Bases of VEGFR-2-Mediated Physiological Function and Pathological Role91
Immunomodulatory Effect of Adipose-Derived Stem Cells: The Cutting Edge of Clinical Application90
Targeting Rho GTPase Signaling Networks in Cancer90
Endometrial and Menstrual Blood Mesenchymal Stem/Stromal Cells: Biological Properties and Clinical Application89
Pseudogene-Derived lncRNAs and Their miRNA Sponging Mechanism in Human Cancer88
Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression87
Cathepsin K: The Action in and Beyond Bone85
Emerging Signal Regulating Potential of Genistein Against Alzheimer’s Disease: A Promising Molecule of Interest85
The mTOR–Autophagy Axis and the Control of Metabolism84
Emerging Roles of Lipophagy in Health and Disease83
Interplay Between Lipid Metabolism and Autophagy83
CCL19 and CCR7 Expression, Signaling Pathways, and Adjuvant Functions in Viral Infection and Prevention83
Autophagy and Stem Cells: Self-Eating for Self-Renewal82
New Insights of Emerging SARS-CoV-2: Epidemiology, Etiology, Clinical Features, Clinical Treatment, and Prevention82
The Inhibitory Effect of Curcumin on Virus-Induced Cytokine Storm and Its Potential Use in the Associated Severe Pneumonia82
Recent Advances of Osterix Transcription Factor in Osteoblast Differentiation and Bone Formation81
The Function of the HGF/c-Met Axis in Hepatocellular Carcinoma81
Cathepsin B Is Required for NLRP3 Inflammasome Activation in Macrophages, Through NLRP3 Interaction80
Tumor Endothelial Cells (TECs) as Potential Immune Directors of the Tumor Microenvironment – New Findings and Future Perspectives80
Role of Epithelial-Mesenchymal Transition in Retinal Pigment Epithelium Dysfunction80
Single-Cell RNA-seq Identifies Cell Subsets in Human Placenta That Highly Expresses Factors Driving Pathogenesis of SARS-CoV-280
Molecular Mechanisms of Cardiomyocyte Death in Drug-Induced Cardiotoxicity79
Mechanoregulation of YAP and TAZ in Cellular Homeostasis and Disease Progression79
Potential Roles of Exosomes in Parkinson’s Disease: From Pathogenesis, Diagnosis, and Treatment to Prognosis78
Neuroinflammation as a Factor of Neurodegenerative Disease: Thalidomide Analogs as Treatments78
MicroRNA Involvement in Signaling Pathways During Viral Infection78
The Mechanics of Mitotic Cell Rounding75
Pleiotropic Effects of mTOR and Autophagy During Development and Aging75
Contribution of TGF-Beta-Mediated NLRP3-HMGB1 Activation to Tubulointerstitial Fibrosis in Rat With Angiotensin II-Induced Chronic Kidney Disease74
Paternal Contributions to Offspring Health: Role of Sperm Small RNAs in Intergenerational Transmission of Epigenetic Information74
X Inactivation and Escape: Epigenetic and Structural Features74
BMSC-Derived Exosomal miR-29a Promotes Angiogenesis and Osteogenesis74
Hepatic Stellate Cells and Hepatocarcinogenesis73
The Role of Exosomes and Exosomal MicroRNA in Cardiovascular Disease73
Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma: Origin, Polarization, Function, and Reprogramming73
Tumor Microenvironment in Ovarian Cancer: Function and Therapeutic Strategy73
Bearing My Heart: The Role of Extracellular Matrix on Cardiac Development, Homeostasis, and Injury Response72
Nicotinamide Mononucleotide: A Promising Molecule for Therapy of Diverse Diseases by Targeting NAD+ Metabolism72
MitophAging: Mitophagy in Aging and Disease72
Mesenchymal Stem Cell Senescence and Rejuvenation: Current Status and Challenges71
Liver Fibrosis: Therapeutic Targets and Advances in Drug Therapy70
Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells70
Mechanism of Acrosome Biogenesis in Mammals69
Two-Faced: Roles of JNK Signalling During Tumourigenesis in the Drosophila Model69
Development and Validation of a Combined Ferroptosis and Immune Prognostic Classifier for Hepatocellular Carcinoma69
Mitochondrial Involvement in Migration, Invasion and Metastasis69
Premature Ovarian Insufficiency: Past, Present, and Future69
Novel Function of lncRNA ADAMTS9-AS2 in Promoting Temozolomide Resistance in Glioblastoma via Upregulating the FUS/MDM2 Ubiquitination Axis69
The Role of Autophagy in Osteoarthritis69
IGF2BP3 From Physiology to Cancer: Novel Discoveries, Unsolved Issues, and Future Perspectives68
Severity Detection for the Coronavirus Disease 2019 (COVID-19) Patients Using a Machine Learning Model Based on the Blood and Urine Tests68
GAP-43 and BASP1 in Axon Regeneration: Implications for the Treatment of Neurodegenerative Diseases66
Transforming Growth Factor-Beta1 in Diabetic Kidney Disease66
Horizontal Gene Transfer: From Evolutionary Flexibility to Disease Progression66
Mitochondria-Associated ER Membranes – The Origin Site of Autophagy66
Transmission Routes Analysis of SARS-CoV-2: A Systematic Review and Case Report66
Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds65
Regulatory Mechanisms of Vitellogenesis in Insects65
Coordinating Proliferation, Polarity, and Cell Fate in the Drosophila Female Germline65
Macrophage Dysregulation and Impaired Skin Wound Healing in Diabetes65
The Ageing Brain: Molecular and Cellular Basis of Neurodegeneration64
Cancer-Associated Fibroblast (CAF) Heterogeneity and Targeting Therapy of CAFs in Pancreatic Cancer64
Structural and Functional Dysbiosis of Fecal Microbiota in Chinese Patients With Alzheimer's Disease64
The Epithelial-to-Mesenchymal Transition as a Possible Therapeutic Target in Fibrotic Disorders64
Exosomes, a New Star for Targeted Delivery64
Evaluating DNA Methylation, Gene Expression, Somatic Mutation, and Their Combinations in Inferring Tumor Tissue-of-Origin63
Roles of Macrophages in the Development and Treatment of Gut Inflammation63
Epigenetics of Male Infertility: The Role of DNA Methylation63
The Current Status of Mesenchymal Stromal Cells: Controversies, Unresolved Issues and Some Promising Solutions to Improve Their Therapeutic Efficacy63
Biological Function of Long Non-coding RNA (LncRNA) Xist63
Cross-Species Analysis of Single-Cell Transcriptomic Data63
Mitochondrial Transfer and Regulators of Mesenchymal Stromal Cell Function and Therapeutic Efficacy62
The Role of Mitochondrial Dynamics and Mitophagy in Carcinogenesis, Metastasis and Therapy62
Mitochondrial Interactome: A Focus on Antiviral Signaling Pathways61
Adipogenesis, Osteogenesis, and Chondrogenesis of Human Mesenchymal Stem/Stromal Cells: A Comparative Transcriptome Approach61
Modeling Cell Communication in Cancer With Organoids: Making the Complex Simple60
Recent Trends in the Development of Bone Regenerative Biomaterials60
Mitochondria, Telomeres and Telomerase Subunits60
Role of Wnt Signaling in Adult Hippocampal Neurogenesis in Health and Disease60
The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines59
Physiological Signaling Functions of Reactive Oxygen Species in Stem Cells: From Flies to Man59
Function and Regulation of IL-36 Signaling in Inflammatory Diseases and Cancer Development59
Mechanisms of Cardiovascular Disorders in Patients With Chronic Kidney Disease: A Process Related to Accelerated Senescence59
Long Non-coding RNAs and MicroRNAs Interplay in Osteogenic Differentiation of Mesenchymal Stem Cells59
CXCL11 Correlates With Antitumor Immunity and an Improved Prognosis in Colon Cancer59
miRNAs in the Diagnosis and Prognosis of Skin Cancer58
The Neurovascular Unit in Glaucomatous Neurodegeneration58
The Role of Notch, Hedgehog, and Wnt Signaling Pathways in the Resistance of Tumors to Anticancer Therapies58
Notch Signaling in Vascular Endothelial Cells, Angiogenesis, and Tumor Progression: An Update and Prospective58
Named Entity Recognition and Relation Detection for Biomedical Information Extraction58
Non-canonical Roles of Telomerase: Unraveling the Imbroglio58
Mitochondrial Dynamics: Fission and Fusion in Fate Determination of Mesenchymal Stem Cells58
Exosomal miRNA-16-5p Derived From M1 Macrophages Enhances T Cell-Dependent Immune Response by Regulating PD-L1 in Gastric Cancer58
Immunomodulatory Properties of Mesenchymal Stromal Cells: An Update57
The Why of YY1: Mechanisms of Transcriptional Regulation by Yin Yang 157
Targeting Cell Death: Pyroptosis, Ferroptosis, Apoptosis and Necroptosis in Osteoarthritis57
Deciphering Epitranscriptome: Modification of mRNA Bases Provides a New Perspective for Post-transcriptional Regulation of Gene Expression57
Connective Tissue Growth Factor: From Molecular Understandings to Drug Discovery57
Patient-Specific Retinal Organoids Recapitulate Disease Features of Late-Onset Retinitis Pigmentosa57
Mitochondria-Associated Endoplasmic Reticulum Membranes in Cardiovascular Diseases57
Novel Techniques of Sperm Selection for Improving IVF and ICSI Outcomes56
Characterization of Human Colon Organoids From Inflammatory Bowel Disease Patients56
The Extracellular Matrix in Skin Inflammation and Infection56
Mutant p53 Gain-of-Function: Role in Cancer Development, Progression, and Therapeutic Approaches56
Role of YAP/TAZ in Cell Lineage Fate Determination and Related Signaling Pathways56
Molecular Aspects and Future Perspectives of Cytokine-Based Anti-cancer Immunotherapy56
Effect of Nuclear Stiffness on Cell Mechanics and Migration of Human Breast Cancer Cells56
Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3): Unraveling the Role in Mediating IGF-Independent Effects Within the Cell56
Targeting Mitochondrial Impairment in Parkinson's Disease: Challenges and Opportunities55
Pluripotent Stem Cell Therapies for Parkinson Disease: Present Challenges and Future Opportunities55
Tissue-Resident Macrophage Development and Function55
Mesenchymal Stromal Cells as Critical Contributors to Tissue Regeneration55
Modeling the Impact of Microgravity at the Cellular Level: Implications for Human Disease54
The Application of Brain Organoids: From Neuronal Development to Neurological Diseases54
Aberrant WNT/CTNNB1 Signaling as a Therapeutic Target in Human Breast Cancer: Weighing the Evidence54
Epithelial-Mesenchymal Transition and Metabolic Switching in Cancer: Lessons From Somatic Cell Reprogramming54
Regeneration of Functional Neurons After Spinal Cord Injury via in situ NeuroD1-Mediated Astrocyte-to-Neuron Conversion54
Scalable Production of Human Mesenchymal Stromal Cell-Derived Extracellular Vesicles Under Serum-/Xeno-Free Conditions in a Microcarrier-Based Bioreactor Culture System54
Unraveling Cardiovascular Risk in Renal Patients: A New Take on Old Tale53
ORF3a-Mediated Incomplete Autophagy Facilitates Severe Acute Respiratory Syndrome Coronavirus-2 Replication53
An Eight-CircRNA Assessment Model for Predicting Biochemical Recurrence in Prostate Cancer53
The Therapeutic Potential of Mesenchymal Stromal Cells for Regenerative Medicine: Current Knowledge and Future Understandings53
Mesenchymal Stem Cells Beyond Regenerative Medicine53
Argonaute Proteins: From Structure to Function in Development and Pathological Cell Fate Determination53
Escape From X-Chromosome Inactivation: An Evolutionary Perspective53
The Integral Role of RNA in Stress Granule Formation and Function52
m6A Regulators Is Differently Expressed and Correlated With Immune Response of Esophageal Cancer52
Brain Neurotransmitter Modulation by Gut Microbiota in Anxiety and Depression52
H3K4me1 Distribution Predicts Transcription State and Poising at Promoters52
Mesenchymal Stem Cell Derived Extracellular Vesicles in Aging52
The Senolytic Drug Navitoclax (ABT-263) Causes Trabecular Bone Loss and Impaired Osteoprogenitor Function in Aged Mice52
Adaptive Mechanisms of Tumor Therapy Resistance Driven by Tumor Microenvironment52
Human Cerebral Organoids and Fetal Brain Tissue Share Proteomic Similarities52
Mesenchymal Stromal Cells and Exosomes: Progress and Challenges52
Targeting Rac and Cdc42 GEFs in Metastatic Cancer52
Signaling Pathways Involved in Diabetic Renal Fibrosis52
Identifying Transcriptomic Signatures and Rules for SARS-CoV-2 Infection51
Development of Extracellular Vesicle Therapeutics: Challenges, Considerations, and Opportunities51
New Insights Into Targeting Membrane Lipids for Cancer Therapy51
Exosomes From Adipose-Derived Stem Cells: The Emerging Roles and Applications in Tissue Regeneration of Plastic and Cosmetic Surgery50
Multiple Functions of ATG8 Family Proteins in Plant Autophagy50
The “Neuro-Glial-Vascular” Unit: The Role of Glia in Neurovascular Unit Formation and Dysfunction50
Guidelines for Regulated Cell Death Assays: A Systematic Summary, A Categorical Comparison, A Prospective50
NOD Signaling and Cell Death50
Running Against the Wnt: How Wnt/β-Catenin Suppresses Adipogenesis50
Complement Receptors and Their Role in Leukocyte Recruitment and Phagocytosis50
Bone and Muscle Crosstalk in Aging50
RANKL/RANK System-Based Mechanism for Breast Cancer Bone Metastasis and Related Therapeutic Strategies49
Lipid Mediated Regulation of Adult Stem Cell Behavior49
The Role of Sperm Centrioles in Human Reproduction – The Known and the Unknown49
Neuron-Oligodendrocyte Interactions in the Structure and Integrity of Axons49
Therapeutic Use of Mesenchymal Stromal Cells: The Need for Inclusive Characterization Guidelines to Accommodate All Tissue Sources and Species49
CircRNA Is a Rising Star in Researches of Ocular Diseases49
A Novel Ten-Gene Signature Predicting Prognosis in Hepatocellular Carcinoma49
Thyroid Hormones Interaction With Immune Response, Inflammation and Non-thyroidal Illness Syndrome49
Exosomal PD-L1: New Insights Into Tumor Immune Escape Mechanisms and Therapeutic Strategies48
Citicoline Protects Auditory Hair Cells Against Neomycin-Induced Damage48
Role of Cholesterol and Lipid Rafts in Cancer Signaling: A Promising Therapeutic Opportunity?48
Four Decades After the Discovery of Regenerating Islet-Derived (Reg) Proteins: Current Understanding and Challenges48
MicroRNA-34a: Potent Tumor Suppressor, Cancer Stem Cell Inhibitor, and Potential Anticancer Therapeutic48
From Flies to Men: ROS and the NADPH Oxidase in Phagocytes47
Glucose Metabolism and Glucose Transporters in Breast Cancer47
Emerging Roles of Exosomal Circular RNAs in Cancer47
Role of Inflammasomes in Kidney Diseases via Both Canonical and Non-canonical Pathways47
Communications Between Bone Marrow Macrophages and Bone Cells in Bone Remodeling47
A Prognostic Ferroptosis-Related lncRNAs Signature Associated With Immune Landscape and Radiotherapy Response in Glioma47
nCOVID-19 Pandemic: From Molecular Pathogenesis to Potential Investigational Therapeutics47
The Roles of 2-Hydroxyglutarate47
Natural Compounds and Autophagy: Allies Against Neurodegeneration46
LRP5 and LRP6 in Wnt Signaling: Similarity and Divergence46
Epigenetic Biomarkers in the Management of Ovarian Cancer: Current Prospectives46
Quercetin Suppresses Apoptosis and Attenuates Intervertebral Disc Degeneration via the SIRT1-Autophagy Pathway46
Primary Cilia, Ciliogenesis and the Actin Cytoskeleton: A Little Less Resorption, A Little More Actin Please46
Endothelial-to-Mesenchymal Transition in Cancer45
The Role of ARF Family Proteins and Their Regulators and Effectors in Cancer Progression: A Therapeutic Perspective45
Ran GTPase: A Key Player in Tumor Progression and Metastasis45
Cadmium-Induced Cytotoxicity: Effects on Mitochondrial Electron Transport Chain45
Targeting Immune Cells in the Tumor Microenvironment of HCC: New Opportunities and Challenges45
The Mitochondrial Response to DNA Damage45
The Role of Tumor-Stroma Interactions in Drug Resistance Within Tumor Microenvironment45
Selective Autophagy Receptor p62/SQSTM1, a Pivotal Player in Stress and Aging45
Mechanisms of Oocyte Maturation and Related Epigenetic Regulation45
Ferroptosis in Acute Central Nervous System Injuries: The Future Direction?45
Fibroblast Senescence in Idiopathic Pulmonary Fibrosis45
Targeting USP7-Mediated Deubiquitination of MDM2/MDMX-p53 Pathway for Cancer Therapy: Are We There Yet?45
Prognostic Significance and Tumor Immune Microenvironment Heterogenicity of m5C RNA Methylation Regulators in Triple-Negative Breast Cancer44
Preventing Mortality in COVID-19 Patients: Which Cytokine to Target in a Raging Storm?44
Interleukin 37 Suppresses M1 Macrophage Polarization Through Inhibition of the Notch1 and Nuclear Factor Kappa B Pathways44
Effect and Regulation of the NLRP3 Inflammasome During Renal Fibrosis44
Down-Regulated Exosomal MicroRNA-221 – 3p Derived From Senescent Mesenchymal Stem Cells Impairs Heart Repair44
Regulation of V-ATPase Activity and Organelle pH by Phosphatidylinositol Phosphate Lipids44
In vivo Neuroregeneration to Treat Ischemic Stroke Through NeuroD1 AAV-Based Gene Therapy in Adult Non-human Primates44
The Hippo Signaling Pathway in Cardiac Development and Diseases44
Mitochondria Donation by Mesenchymal Stem Cells: Current Understanding and Mitochondria Transplantation Strategies44
Development and Validation of a Robust Ferroptosis-Related Prognostic Signature in Lung Adenocarcinoma44
Autophagy in T Cell Function and Aging44
B Cell Orchestration of Anti-tumor Immune Responses: A Matter of Cell Localization and Communication44
Insights Into the Role of CircRNAs: Biogenesis, Characterization, Functional, and Clinical Impact in Human Malignancies43
Modeling Rett Syndrome With Human Patient-Specific Forebrain Organoids43
Mesenchymal Stem Cells Adaptively Respond to Environmental Cues Thereby Improving Granulation Tissue Formation and Wound Healing43
Modeling Inflammation in Zebrafish for the Development of Anti-inflammatory Drugs43
Blockade of GCH1/BH4 Axis Activates Ferritinophagy to Mitigate the Resistance of Colorectal Cancer to Erastin-Induced Ferroptosis43
Molecular Crosstalk Between MYC and HIF in Cancer43
When Stiffness Matters: Mechanosensing in Heart Development and Disease43
The Dimensions of Primary Mitochondrial Disorders42
A Critical Perspective on 3D Liver Models for Drug Metabolism and Toxicology Studies42
Insights on SARS-CoV-2 Molecular Interactions With the Renin-Angiotensin System42
Expression of m6A Regulators Correlated With Immune Microenvironment Predicts Therapeutic Efficacy and Prognosis in Gliomas42
Osteoclast Signal Transduction During Bone Metastasis Formation42
Next-Generation Liver Medicine Using Organoid Models42
Cardiomyocyte Proliferation and Maturation: Two Sides of the Same Coin for Heart Regeneration42
Induction of Autophagy by Pterostilbene Contributes to the Prevention of Renal Fibrosis via Attenuating NLRP3 Inflammasome Activation and Epithelial-Mesenchymal Transition42
Two Types of Contact Between Lipid Droplets and Mitochondria42
Doxycycline Inducible Chimeric Antigen Receptor T Cells Targeting CD147 for Hepatocellular Carcinoma Therapy42
Obesity and Bone Health: A Complex Link42
Niches for Skeletal Stem Cells of Mesenchymal Origin41
Ion Transport in Eryptosis, the Suicidal Death of Erythrocytes41
Is Senescence-Associated β-Galactosidase a Reliable in vivo Marker of Cellular Senescence During Embryonic Development?41
Global Research Trends of Ferroptosis: A Rapidly Evolving Field With Enormous Potential41
Exosomes in the Regulation of Vascular Endothelial Cell Regeneration41
Agephagy – Adapting Autophagy for Health During Aging41
Identification and Validation of Pyroptosis-Related Gene Signature to Predict Prognosis and Reveal Immune Infiltration in Hepatocellular Carcinoma41
A Guide to Nucleic Acid Vaccines in the Prevention and Treatment of Infectious Diseases and Cancers: From Basic Principles to Current Applications41
Targeting the HGF/MET Axis in Cancer Therapy: Challenges in Resistance and Opportunities for Improvement41
Subchondral Bone Remodeling: A Therapeutic Target for Osteoarthritis41
Liraglutide Alleviates Hepatic Steatosis by Activating the TFEB-Regulated Autophagy-Lysosomal Pathway41
Mesenchymal Stem Cell-Macrophage Crosstalk and Maintenance of Inflammatory Microenvironment Homeostasis41
Mitochondrial Dynamics in Adult Cardiomyocytes and Heart Diseases40
Emerging Roles of Liquid–Liquid Phase Separation in Cancer: From Protein Aggregation to Immune-Associated Signaling40
N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and Applications40
Mitochondrial Function and Dysfunction in Dilated Cardiomyopathy40
Nerves in the Tumor Microenvironment: Origin and Effects40
USP7 Is a Master Regulator of Genome Stability40
The Role of RNA Splicing Factors in Cancer: Regulation of Viral and Human Gene Expression in Human Papillomavirus-Related Cervical Cancer40
Cancer Stem Cells: Emerging Key Players in Immune Evasion of Cancers40
Cardiac Fibroblasts and Cardiac Fibrosis: Precise Role of Exosomes40
Protein Amphipathic Helix Insertion: A Mechanism to Induce Membrane Fission40
Genetic Engineering as a Strategy to Improve the Therapeutic Efficacy of Mesenchymal Stem/Stromal Cells in Regenerative Medicine40
CDKN2a/p16 Antagonizes Hepatic Stellate Cell Activation and Liver Fibrosis by Modulating ROS Levels40
Identifying Antioxidant Proteins by Using Amino Acid Composition and Protein-Protein Interactions40
Inflammation and Wnt Signaling: Target for Immunomodulatory Therapy?40
Selective Autophagy of the Protein Homeostasis Machinery: Ribophagy, Proteaphagy and ER-Phagy40
A New World of Biomarkers and Therapeutics for Female Reproductive System and Breast Cancers: Circular RNAs40
CDP-Diacylglycerol Synthases (CDS): Gateway to Phosphatidylinositol and Cardiolipin Synthesis40
CD226: An Emerging Role in Immunologic Diseases40
The MicroRNA Family Gets Wider: The IsomiRs Classification and Role39
COVID-19 and the Vasculature: Current Aspects and Long-Term Consequences39
Integrating the Hallmarks of Aging Throughout the Tree of Life: A Focus on Mitochondrial Dysfunction39
Roles of N6-Methyladenosine (m6A) in Stem Cell Fate Decisions and Early Embryonic Development in Mammals39
Primary Mammary Organoid Model of Lactation and Involution39
Recent Update of HDAC Inhibitors in Lymphoma39
Developmental Stage-Specific Distribution of Macrophages in Mouse Mammary Gland39
Mitochondrial Function in Muscle Stem Cell Fates39
Adherens Junctions: Guardians of Cortical Development39
Exosome-Based Delivery of Natural Products in Cancer Therapy39
Endosome-to-TGN Trafficking: Organelle-Vesicle and Organelle-Organelle Interactions39
Mesenchymal Stem Cells: Allogeneic MSC May Be Immunosuppressive but Autologous MSC Are Dysfunctional in Lupus Patients39
Heterochromatin as an Important Driver of Genome Organization39
Midbrain Organoids: A New Tool to Investigate Parkinson’s Disease39
Connecting the Dots: Resolving the Bone Marrow Niche Heterogeneity39
SERPINA1 Gene Promoter Is Differentially Methylated in Peripheral Blood Mononuclear Cells of Pregnant Women38
The Effects of Biomaterial Implant Wear Debris on Osteoblasts38
Transport of Ciliary Membrane Proteins38
Disease Activity-Associated Alteration of mRNA m5 C Methylation in CD4+ T Cells of Systemic Lupus Erythematosus38
Structural Characteristics, Binding Partners and Related Diseases of the Calponin Homology (CH) Domain38
Toward a Better Understanding of Neuronal Migration Deficits in Autism Spectrum Disorders38
TGF-β Signaling and Resistance to Cancer Therapy38
Freeze-Dried Extracellular Vesicles From Adipose-Derived Stem Cells Prevent Hypoxia-Induced Muscle Cell Injury38
Mitochondrial OMA1 and OPA1 as Gatekeepers of Organellar Structure/Function and Cellular Stress Response38
Fusobacterium nucleatum Acts as a Pro-carcinogenic Bacterium in Colorectal Cancer: From Association to Causality38
Adrenoleukodystrophy Newborn Screening in the Netherlands (SCAN Study): The X-Factor38
The Function of Astrocyte Mediated Extracellular Vesicles in Central Nervous System Diseases38
Integrin-Ligand Interactions in Inflammation, Cancer, and Metabolic Disease: Insights Into the Multifaceted Roles of an Emerging Ligand Irisin38
LncRNA KCNQ1OT1 Secreted by Tumor Cell-Derived Exosomes Mediates Immune Escape in Colorectal Cancer by Regulating PD-L1 Ubiquitination via MiR-30a-5p/USP2238
Therapeutic Potential of Wharton’s Jelly Mesenchymal Stem Cells for Diabetes: Achievements and Challenges38
The Role of Short-Chain Fatty Acids and Bile Acids in Intestinal and Liver Function, Inflammation, and Carcinogenesis37
Circular RNA hsa_circ_0004277 Stimulates Malignant Phenotype of Hepatocellular Carcinoma and Epithelial-Mesenchymal Transition of Peripheral Cells37
Histone Deacetylase Inhibition in Non-small Cell Lung Cancer: Hype or Hope?37
Monitoring the Sphingolipid de novo Synthesis by Stable-Isotope Labeling and Liquid Chromatography-Mass Spectrometry37
Cell-Free DNA: Hope and Potential Application in Cancer37
Reactive Oxygen Species: Not Omnipresent but Important in Many Locations37
Mesenchymal Stem Cell Derived Extracellular Vesicles Ameliorate Kidney Injury in Aristolochic Acid Nephropathy37
The Role of Autophagy in Gastric Cancer Chemoresistance: Friend or Foe?37
The Role of Gut Microbial β-Glucuronidase in Estrogen Reactivation and Breast Cancer37
Mesenchymal Stromal Cell-Produced Components of Extracellular Matrix Potentiate Multipotent Stem Cell Response to Differentiation Stimuli37
Friend or Foe? Recent Strategies to Target Myeloid Cells in Cancer37
Telomere Replication: Solving Multiple End Replication Problems37
Non-syndromic Cleft Palate: An Overview on Human Genetic and Environmental Risk Factors37
Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Lung Diseases: Current Status and Perspectives36
Determinants and Functions of CAFs Secretome During Cancer Progression and Therapy36
Neural Stem Cells and Methods for Their Generation From Induced Pluripotent Stem Cells in vitro36
The Role of Proteoglycans in Cancer Metastasis and Circulating Tumor Cell Analysis36
Neural Stem Cell-Derived Exosomes Regulate Neural Stem Cell Differentiation Through miR-9-Hes1 Axis36
Molecular Insights Into Therapeutic Potential of Autophagy Modulation by Natural Products for Cancer Stem Cells36
Functional Versatility of the CDK Inhibitor p57Kip236
Genome-Wide Analysis of Circular RNAs Mediated ceRNA Regulation in Porcine Embryonic Muscle Development36
Metabolism and Innate Immunity Meet at the Mitochondria36
Comparative Genomics of Peroxisome Biogenesis Proteins: Making Sense of the PEX Proteins36
Membrane-Interacting Antifungal Peptides36
Alpha Synuclein Connects the Gut-Brain Axis in Parkinson’s Disease Patients – A View on Clinical Aspects, Cellular Pathology and Analytical Methodology36
Self-Generated Gradients Yield Exceptionally Robust Steering Cues36
Pre-metastatic Niche Formation in Different Organs Induced by Tumor Extracellular Vesicles36
Anti-tumor Effect of Oleic Acid in Hepatocellular Carcinoma Cell Lines via Autophagy Reduction36
The m6A Reader YTHDF1 Facilitates the Tumorigenesis and Metastasis of Gastric Cancer via USP14 Translation in an m6A-Dependent Manner36
Small Molecule Chaperones for the Treatment of Gaucher Disease and GBA1-Associated Parkinson Disease36
Emerging Role of Exosomes in Liquid Biopsy for Monitoring Prostate Cancer Invasion and Metastasis36
Mitochondrial Quality Control Governed by Ubiquitin36
Dissecting the Role of the FGF19-FGFR4 Signaling Pathway in Cancer Development and Progression36
The Elusive Endometrial Epithelial Stem/Progenitor Cells35
Targeting NR4A Nuclear Receptors to Control Stromal Cell Inflammation, Metabolism, Angiogenesis, and Tumorigenesis35
A Positive Feedback Loop of Hippo- and c-Jun-Amino-Terminal Kinase Signaling Pathways Regulates Amyloid-Beta-Mediated Neurodegeneration35
Ferroptosis, a Potential Therapeutic Target in Alzheimer’s Disease35
Histone Deacetylase Inhibitors to Overcome Resistance to Targeted and Immuno Therapy in Metastatic Melanoma35
A Promising Future of Ferroptosis in Tumor Therapy35
Dissecting the Crosstalk Between Nrf2 and NF-κB Response Pathways in Drug-Induced Toxicity35
Long Non-coding RNA LINC-PINT Suppresses Cell Proliferation and Migration of Melanoma via Recruiting EZH235
New Understanding of the Relevant Role of LINE-1 Retrotransposition in Human Disease and Immune Modulation35
Age-Related Macular Degeneration Revisited: From Pathology and Cellular Stress to Potential Therapies35
Why Do Intrauterine Exposure to Air Pollution and Cigarette Smoke Increase the Risk of Asthma?35
Extracellular Vesicles Derived From Apoptotic Cells: An Essential Link Between Death and Regeneration35
HGF and MET: From Brain Development to Neurological Disorders35
The Role of FoxG1 in the Inner Ear35
The Roles of Epigenetics Regulation in Bone Metabolism and Osteoporosis35
Engineered Extracellular Vesicles Loaded With miR-124 Attenuate Cocaine-Mediated Activation of Microglia35
Regulation of Myostatin on the Growth and Development of Skeletal Muscle35
Biophysical and Biochemical Cues of Biomaterials Guide Mesenchymal Stem Cell Behaviors35
From Sperm Motility to Sperm-Borne microRNA Signatures: New Approaches to Predict Male Fertility Potential35
Molecular Basis for CCRL2 Regulation of Leukocyte Migration34
Senolytics: A Translational Bridge Between Cellular Senescence and Organismal Aging34
Extension of Cellular Lifespan by Methionine Restriction Involves Alterations in Central Carbon Metabolism and Is Mitophagy-Dependent34
Biological Properties of Milk-Derived Extracellular Vesicles and Their Physiological Functions in Infant34
Extracellular RNA as a Versatile DAMP and Alarm Signal That Influences Leukocyte Recruitment in Inflammation and Infection34
Infrapatellar Fat Pad Stem Cells Responsiveness to Microenvironment in Osteoarthritis: From Morphology to Function34
Endoplasmic Reticulum Stress and Mitochondrial Function in Airway Smooth Muscle34
The Structural Biology of Septins and Their Filaments: An Update34
Beyond the Blood: CSF-Derived cfDNA for Diagnosis and Characterization of CNS Tumors34
Mitochondria: An Integrative Hub Coordinating Circadian Rhythms, Metabolism, the Microbiome, and Immunity34
NUMT Confounding Biases Mitochondrial Heteroplasmy Calls in Favor of the Reference Allele34
The Chromatin Remodeler Brg1 Integrates ROS Production and Endothelial-Mesenchymal Transition to Promote Liver Fibrosis in Mice34
Dendritic Spine and Synaptic Plasticity in Alzheimer’s Disease: A Focus on MicroRNA34
Vertebrate Sensory Ganglia: Common and Divergent Features of the Transcriptional Programs Generating Their Functional Specialization34
Chondral Differentiation of Induced Pluripotent Stem Cells Without Progression Into the Endochondral Pathway34
LncRNA-MIAT-Mediated miR-214-3p Silencing Is Responsible for IL-17 Production and Cardiac Fibrosis in Diabetic Cardiomyopathy34
Methods for Accurate Assessment of Myofiber Maturity During Skeletal Muscle Regeneration34
‘Omics Approaches to Explore the Breast Cancer Landscape34
TNFR2 Is a Crucial Hub Controlling Mesenchymal Stem Cell Biological and Functional Properties34
SARS-CoV-2-Specific Memory T Lymphocytes From COVID-19 Convalescent Donors: Identification, Biobanking, and Large-Scale Production for Adoptive Cell Therapy34
Premyelinating Oligodendrocytes: Mechanisms Underlying Cell Survival and Integration34
Gastric Stem Cells: Physiological and Pathological Perspectives33
MiT/TFE Family of Transcription Factors: An Evolutionary Perspective33
Toll-Like Receptors as a Therapeutic Target in the Era of Immunotherapies33
Amino Acids of Seminal Plasma Associated With Freezability of Bull Sperm33
Exosomal miR-128-3p Promotes Epithelial-to-Mesenchymal Transition in Colorectal Cancer Cells by Targeting FOXO4 via TGF-β/SMAD and JAK/STAT3 Signaling33
Knockdown of lncRNA MALAT1 Alleviates LPS-Induced Acute Lung Injury via Inhibiting Apoptosis Through the miR-194-5p/FOXP2 Axis33
Periodontal Inflammation-Triggered by Periodontal Ligament Stem Cell Pyroptosis Exacerbates Periodontitis33
MicroRNA-221/222 Mediates ADSC-Exosome-Induced Cardioprotection Against Ischemia/Reperfusion by Targeting PUMA and ETS-133
Dental-Derived Mesenchymal Stem Cells: State of the Art33
Endoplasmic Reticulum–Mitochondria Contact Sites and Neurodegeneration33
Disrupted Neurogenesis in Germ-Free Mice: Effects of Age and Sex33
Mechanical Cues Affect Migration and Invasion of Cells From Three Different Directions33
The Paradoxical Role of Cellular Senescence in Cancer33
Sensing R-Loop-Associated DNA Damage to Safeguard Genome Stability33
piRNA-823 Is Involved in Cancer Stem Cell Regulation Through Altering DNA Methylation in Association With Luminal Breast Cancer33
Telomere Length Measurement by Molecular Combing33
Targeting Lipid Rafts as a Strategy Against Coronavirus33
Role of Proton-Coupled Monocarboxylate Transporters in Cancer: From Metabolic Crosstalk to Therapeutic Potential33
Cyclin E/CDK2: DNA Replication, Replication Stress and Genomic Instability33
Essential Role of Sperm-Specific PLC-Zeta in Egg Activation and Male Factor Infertility: An Update33
Resveratrol Improves Bnip3-Related Mitophagy and Attenuates High-Fat-Induced Endothelial Dysfunction33
Single-Cell RNA-Sequencing From Mouse Incisor Reveals Dental Epithelial Cell-Type Specific Genes33
Notch Signalling in Breast Development and Cancer33
STING1 Promotes Ferroptosis Through MFN1/2-Dependent Mitochondrial Fusion33
Tumor Associated Macrophages, as the Dominant Immune Cells, Are an Indispensable Target for Immunologically Cold Tumor—Glioma Therapy?33
Receptor Oligomerization and Its Relevance for Signaling by Receptors of the Tumor Necrosis Factor Receptor Superfamily33
Dual Role of Autophagy in Regulation of Mesenchymal Stem Cell Senescence33
SOD1 Promotes Cell Proliferation and Metastasis in Non-small Cell Lung Cancer via an miR-409-3p/SOD1/SETDB1 Epigenetic Regulatory Feedforward Loop33
Comprehensive Analysis of the Prognostic Role and Mutational Characteristics of m6A-Related Genes in Lung Squamous Cell Carcinoma33
Organoid Models of Glioblastoma to Study Brain Tumor Stem Cells33
Extracellular Vesicles Are Key Regulators of Tumor Neovasculature32
Characterization of Factors Involved in Localized Translation Near Mitochondria by Ribosome-Proximity Labeling32
Fat Wasting Is Damaging: Role of Adipose Tissue in Cancer-Associated Cachexia32
3D Cell Culture Models Demonstrate a Role for FGF and WNT Signaling in Regulation of Lung Epithelial Cell Fate and Morphogenesis32
Biological Roles and Delivery Strategies for Ions to Promote Osteogenic Induction32
Identification and Validation of a Nine-Gene Amino Acid Metabolism-Related Risk Signature in HCC32
The Role of ADF/Cofilin in Synaptic Physiology and Alzheimer’s Disease32
Rab GTPases: Central Coordinators of Membrane Trafficking in Cancer32
Deletion of Kcnj16 in Mice Does Not Alter Auditory Function32
The Role of Atypical Ubiquitin Chains in the Regulation of the Antiviral Innate Immune Response32
The Nuclear Mitotic Apparatus (NuMA) Protein: A Key Player for Nuclear Formation, Spindle Assembly, and Spindle Positioning32
Understanding the Multiple Role of Mitochondria in Parkinson’s Disease and Related Disorders: Lesson From Genetics and Protein–Interaction Network32
Updating the Free Radical Theory of Aging32
The Role of an IL-10/Hyaluronan Axis in Dermal Wound Healing32
The Art of Intercellular Wireless Communications: Exosomes in Heart Disease and Therapy32
The Lysosomal Membrane Protein Lamp2 Alleviates Lysosomal Cell Death by Promoting Autophagic Flux in Ischemic Cardiomyocytes32
Mitochondrial Dysfunction: Cause or Consequence of Vascular Calcification?32
Energy and Dynamics of Caveolae Trafficking32
Expression of Lipid-Metabolism Genes Is Correlated With Immune Microenvironment and Predicts Prognosis in Osteosarcoma32
Neurovascular Coupling in Development and Disease: Focus on Astrocytes32
Development and Validation of a Hypoxia-Associated Prognostic Signature Related to Osteosarcoma Metastasis and Immune Infiltration32
Mitochondrial Dysfunction in Astrocytes: A Role in Parkinson’s Disease?32
The Cellular Origins of Cancer-Associated Fibroblasts and Their Opposing Contributions to Pancreatic Cancer Growth32
Regulation of Wnt Signaling Pathways at the Plasma Membrane and Their Misregulation in Cancer32
The Gut Microbiota, Kynurenine Pathway, and Immune System Interaction in the Development of Brain Cancer32
How Malaria Parasites Acquire Nutrients From Their Host32
Chromosome Organization in Early Meiotic Prophase32
A Novel Mechanism of Cannabidiol in Suppressing Hepatocellular Carcinoma by Inducing GSDME Dependent Pyroptosis32
Ferroptosis: A Novel Therapeutic Target for Ischemia-Reperfusion Injury32
Native and Bioengineered Exosomes for Ischemic Stroke Therapy32
Circular RNAs: Functions and Clinical Significance in Cardiovascular Disease32
Non-coding RNAs in Nervous System Development and Disease32
One-Carbon Metabolism Regulates Embryonic Stem Cell Fate Through Epigenetic DNA and Histone Modifications: Implications for Transgenerational Metabolic Disorders in Adults32
Two Decades of Global Progress in Authorized Advanced Therapy Medicinal Products: An Emerging Revolution in Therapeutic Strategies32
MiR-144-3p Enhances Cardiac Fibrosis After Myocardial Infarction by Targeting PTEN32
Congruence of Transcription Programs in Adult Stem Cell-Derived Jejunum Organoids and Original Tissue During Long-Term Culture32
Order Through Disorder: The Characteristic Variability of Systems32
Extracellular Vesicle-Dependent Communication Between Mesenchymal Stromal Cells and Immune Effector Cells31
Exosomes Secreted by Adipose-Derived Mesenchymal Stem Cells Foster Metastasis and Osteosarcoma Proliferation by Increasing COLGALT2 Expression31
Ferroptosis and Its Potential Role in Metabolic Diseases: A Curse or Revitalization?31
The Multifaceted Roles of Proline in Cell Behavior31
Immune (Cell) Derived Exosome Mimetics (IDEM) as a Treatment for Ovarian Cancer31
Membrane Heterogeneity Controls Cellular Endocytic Trafficking31
m7G Methyltransferase METTL1 Promotes Post-ischemic Angiogenesis via Promoting VEGFA mRNA Translation31
Activation of TWIST Transcription by Chromatin Remodeling Protein BRG1 Contributes to Liver Fibrosis in Mice31
Human Umbilical Mesenchymal Stem Cells Display Therapeutic Potential in Rheumatoid Arthritis by Regulating Interactions Between Immunity and Gut Microbiota via the Aryl Hydrocarbon Receptor31
Mitophagy in Diabetic Cardiomyopathy: Roles and Mechanisms31
Mitoepigenetics and Its Emerging Roles in Cancer31
ARF GTPases and Their Ubiquitous Role in Intracellular Trafficking Beyond the Golgi31
Role of Small Molecule Targeted Compounds in Cancer: Progress, Opportunities, and Challenges31
Sphingolipids as Modulators of SARS-CoV-2 Infection31
Hec1/Ndc80 Tail Domain Function at the Kinetochore-Microtubule Interface31
m5C-Related lncRNAs Predict Overall Survival of Patients and Regulate the Tumor Immune Microenvironment in Lung Adenocarcinoma31
Cell Metabolism and DNA Repair Pathways: Implications for Cancer Therapy31
Fanconi Anemia Pathway: Mechanisms of Breast Cancer Predisposition Development and Potential Therapeutic Targets31
Roles of Non-coding RNAs and Angiogenesis in Glioblastoma31
Targeting Integrins for Cancer Therapy - Disappointments and Opportunities30
Pros and Cons of Denosumab Treatment for Osteoporosis and Implication for RANKL Aptamer Therapy30
Employing Flow Cytometry to Extracellular Vesicles Sample Microvolume Analysis and Quality Control30
From Mesenchymal Stromal Cells to Engineered Extracellular Vesicles: A New Therapeutic Paradigm30
Prognostic Nutritional Index (PNI) in Patients With Breast Cancer Treated With Neoadjuvant Chemotherapy as a Useful Prognostic Indicator30
Mechanism and Control of Meiotic DNA Double-Strand Break Formation in S. cerevisiae30
Functional and Pathological Roles of AHCY30
Histone Deacetylase 11 Contributes to Renal Fibrosis by Repressing KLF15 Transcription30
Oxidized LDL Causes Endothelial Apoptosis by Inhibiting Mitochondrial Fusion and Mitochondria Autophagy30
Hematopoietic Stem Cell Niche During Homeostasis, Malignancy, and Bone Marrow Transplantation30
Ferroptosis Signaling and Regulators in Atherosclerosis30
Recent Advances in the Controlled Release of Growth Factors and Cytokines for Improving Cutaneous Wound Healing30
Biological Significance of NOTCH Signaling Strength30
MicroRNA-138-5p Suppresses Non-small Cell Lung Cancer Cells by Targeting PD-L1/PD-1 to Regulate Tumor Microenvironment30
Brain Ultrastructure: Putting the Pieces Together30
Diverse Facets of Sphingolipid Involvement in Bacterial Infections30
Discovery of Exosomes From Tick Saliva and Salivary Glands Reveals Therapeutic Roles for CXCL12 and IL-8 in Wound Healing at the Tick–Human Skin Interface30
Dysfunction of Mitochondrial Ca2+ Regulatory Machineries in Brain Aging and Neurodegenerative Diseases30
Clinical Translation of Mesenchymal Stromal Cell Therapy for Graft Versus Host Disease30
Autophagy, Pyroptosis, and Ferroptosis: New Regulatory Mechanisms for Atherosclerosis29
Aging and Senescence of Dental Pulp and Hard Tissues of the Tooth29
Mitochondrial Protein Translation: Emerging Roles and Clinical Significance in Disease29
The Multifunctional Contribution of FGF Signaling to Cardiac Development, Homeostasis, Disease and Repair29
An FGFR/AKT/SOX2 Signaling Axis Controls Pancreatic Cancer Stemness29
Importance of Long Non-coding RNAs in the Development and Disease of Skeletal Muscle and Cardiovascular Lineages29
The Secretive Life of Neutrophils Revealed by Intravital Microscopy29
Resistance to Anti-angiogenic Therapies: A Mechanism Depending on the Time of Exposure to the Drugs29
Exosomes Mediated Transfer of Circ_0000337 Contributes to Cisplatin (CDDP) Resistance of Esophageal Cancer by Regulating JAK2 via miR-377-3p29
Advances in Aptamer-Based Biomarker Discovery29
Epigenetic Regulation of a Disintegrin and Metalloproteinase (ADAM) Transcription in Colorectal Cancer Cells: Involvement of β-Catenin, BRG1, and KDM429
The Intertwined Evolution and Development of Sutures and Cranial Morphology29