OOIR: Observatory of International Research

Papers

(The H4-Index of Frontiers in Bioengineering and Biotechnology is 70. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Bioreactor as the root cause of the “manganese effect” during Aspergillus niger citric acid fermentations	398
BRET-based biosensors for SARS-CoV-2 oligonucleotide detection	372
Pan-Cancer Single-Cell Analysis Reveals the Core Factors and Pathway in Specific Cancer Stem Cells of Upper Gastrointestinal Cancer	290
Craniocaudal cyclic load improves risk assessment of lumbar pedicle screw loosening: finite element analysis based on computer tomography	211
Numerical Simulation and Deep Neural Network Revealed Drag Reduction of Microstructured Three-Dimensional Square Cylinders at High Reynolds Numbers	192
A scalable corneal xenograft platform: simultaneous opportunities for tissue engineering and circular economic sustainability by repurposing slaughterhouse waste	189
Micropatterned Poly(D,L-Lactide-Co-Caprolactone) Conduits With KHI-Peptide and NGF Promote Peripheral Nerve Repair After Severe Traction Injury	187
Synthesis of Ce/Gd@HA/PLGA Scaffolds Contributing to Bone Repair and MRI Enhancement	177
Wnt signaling directs human pluripotent stem cells into vascularized cardiac organoids with chamber-like structures	172
Erroneous Belief that Digestive Stability Predicts Allergenicity May Lead to Greater Risk for Novel Food Proteins	169
Automated diagnosis and grading of lumbar intervertebral disc degeneration based on a modified YOLO framework	165
Editorial: Using Motion Analysis Techniques and Musculoskeletal Modeling of the Spine to Better Understand Spinal Disorders and Evaluate Treatment Effects	151
Self-assembled microtissues loaded with osteogenic MSCs for in vivo bone regeneration	135
Neural Network-Based Optimization of an Acousto Microfluidic System for Submicron Bioparticle Separation	134
Rapid molecular detection of Senecavirus A based on reverse transcription loop-mediated isothermal amplification (RT-LAMP) and CRISPR/Cas12a	128
Extrusion-based 3D printing of osteoinductive scaffolds with a spongiosa-inspired structure	120
Exploring the relationship between bearing extrusion and postoperative persistent pain in Oxford unicompartmental knee arthroplasty: A trajectory measurement study	117
Editorial: Biofabricated materials for tissue engineering	114
Hydrogel co-loading SO2 prodrug and FeGA nanoparticles for enhancing chemodynamic therapy by photothermal-triggered SO2 gas therapy	114
Urine-derived stem cells: a sustainable resource for advancing personalized medicine and dental regeneration	112
Cholesteric liquid crystal biosensor platform with image analysis for rapid detection of COVID-19	111
Stability of internal fixation systems based on different subtypes of Schatzker II fracture of the tibial plateau: A finite element analysis	110
Harnessing accurate mitochondrial DNA base editing mediated by DdCBEs in a predictable manner	107
Short-term digital ocular massage may weaken corneal biomechanics	105
Editorial: Bioengineering of biomimetic microenvironments for cardiac tissue engineering	103

SMaRT modulation of tau isoforms rescues cognitive and motor impairments in a preclinical model of tauopathy	100
Editorial: Smart Stimuli-responsive Biomaterials for Programmed Drug Delivery	100
Mechanistic insights into the biological activity of S-Sulfocysteine in CHO cells using a multi-omics approach	99
Investigations into the effects of scaffold microstructure on slow-release system with bioactive factors for bone repair	99
The associations between lumbar proprioception and postural control during and after calf vibration in people with and without chronic low back pain	99
Shoe choice may affect fencing lunge attack performance	98
Transfer mechanism of cell-free synthesized membrane proteins into mammalian cells	96
The efficacy of vancomycin-loaded biphasic calcium phosphate bone substitute in the promotion of new bone growth and the prevention of postoperative infection	95
The microbial production of kynurenic acid using Yarrowia lipolytica yeast growing on crude glycerol and soybean molasses	94
Transcriptomic Analysis of Mature Transgenic Poplar Expressing the Transcription Factor JERF36 Gene in Two Different Environments	94
Dual-Use Quickscan: A Web-Based Tool to Assess the Dual-Use Potential of Life Science Research	93
Dual in Utero Electroporation in Mice to Manipulate Two Specific Neuronal Populations in the Developing Cortex	93
Biomechanical evaluation of a novel individualized zero-profile cage for anterior cervical discectomy and fusion: a finite element analysis	90
Effects of non-invasive cervical spinal cord neuromodulation by trans-spinal electrical stimulation on cortico-muscular descending patterns in upper extremity of chronic stroke	88
Hybrid and adaptive control of functional electrical stimulation to correct hemiplegic gait for patients after stroke	87
Accurate classification of benign and malignant breast tumors in ultrasound imaging with an enhanced deep learning model	86
Current applications of nanomaterials in urinary system tumors	85
Editorial: Multipotent stromal cells and microenvironment of the tissue healing	84
MSC in Tendon and Joint Disease: The Context-Sensitive Link Between Targets and Therapeutic Mechanisms	84
Porous Geometry Guided Micro-mechanical Environment Within Scaffolds for Cell Mechanobiology Study in Bone Tissue Engineering	83
Detection of calcitonin gene-related peptide based on increased antigen-driven interaction with antibody variable regions	83
Nanomaterials reshape the pulmonary mechanical microenvironment: novel therapeutic strategies for respiratory diseases	80
Editorial: Metabolic engineering for bioresources and bioenergies production from microalgae	79
Editorial: Biomechanics, aging, exercise and other interventions	79
Genetically engineered CD80–pMHC-harboring extracellular vesicles for antigen-specific CD4+ T-cell engagement	79
Protection by Ankle Brace for Lower-Extremity Joints in Half-Squat Parachuting Landing With a Backpack	78
Modulation of sirtuins during monolayer chondrocyte culture influences cartilage regeneration upon transfer to a 3D culture environment	76
Hydration monitoring and rehydration guidance system for athletes based on urine color’s Lab* parameters	76
Regulatory challenges and global trade implications of genome editing in agriculture	75
Altered activation patterns of the sensory-motor cortex in patients with knee osteoarthritis during knee isokinetic movement at different speeds	75
From a Hetero- to a Methylotrophic Lifestyle: Flash Back on the Engineering Strategies to Create Synthetic Methanol-User Strains	74
Hydrogel Development for Rotator Cuff Repair	73
Optimization of guanosine-based hydrogels with boric acid derivatives for enhanced long-term stability and cell survival	73
The effects of different carbon-fiber plate shapes in shoes on lower limb biomechanics following running-induced fatigue	73
Enabling the complete valorization of hybrid Pennisetum: Directly using alkaline black liquor for preparing UV-shielding biodegradable films	73
A Modified Hyaluronic Acid–Based Dissolving Microneedle Loaded With Daphnetin Improved the Treatment of Psoriasis	72
Kinetic studies and CFD-based reaction modeling for insights into the scalability of ADC conjugation reactions	72
Hydrogel-Based Enzyme and Cofactor Co-Immobilization for Efficient Continuous Transamination in a Microbioreactor	72
Agri-Nanotechnology and Tree Nanobionics: Augmentation in Crop Yield, Biosafety, and Biomass Accumulation	72
Global research trends in extracellular vesicles based on stem cells from 1991 to 2021: A bibliometric and visualized study	72
Microneedle-mediated drug delivery for cutaneous diseases	71
Screening of Hibiscus and Cinnamomum Plants and Identification of Major Phytometabolites in Potential Plant Extracts Responsible for Apoptosis Induction in Skin Melanoma and Lung Adenocarcinoma Cells	71
Characterization and Heterologous Expression of UDP-Glucose 4-Epimerase From a Hericium erinaceus Mutant with High Polysaccharide Production	71
Cyclic RGD functionalized PLGA nanoparticles loaded with noncovalent complex of indocyanine green with urokinase for synergistic thrombolysis	70
Design feature combinations effects of running shoe on plantar pressure during heel landing: A finite element analysis with Taguchi optimization approach	70