Frontiers in Oncology

Papers
(The TQCC of Frontiers in Oncology is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-02-01 to 2024-02-01.)
ArticleCitations
Tumor-Associated Macrophages: Recent Insights and Therapies371
Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis242
CRISPR Gene Therapy: Applications, Limitations, and Implications for the Future219
Resistance Mechanisms to Anti-angiogenic Therapies in Cancer198
EMT Factors and Metabolic Pathways in Cancer191
Tumor-Associated Macrophages in Human Breast, Colorectal, Lung, Ovarian and Prostate Cancers183
Hypoxia-Induced Epithelial-Mesenchymal Transition in Cancers: HIF-1α and Beyond165
Nanobodies: Next Generation of Cancer Diagnostics and Therapeutics160
Tumor Microenvironment: Extracellular Matrix Alterations Influence Tumor Progression148
Chronic Stress Promotes Cancer Development144
Disialoganglioside GD2 Expression in Solid Tumors and Role as a Target for Cancer Therapy144
Mechanisms of Cancer Resistance to Immunotherapy141
Altered Iron Metabolism and Impact in Cancer Biology, Metastasis, and Immunology140
The Double-Edge Sword of Autophagy in Cancer: From Tumor Suppression to Pro-tumor Activity137
Long Non-Coding RNAs: The Regulatory Mechanisms, Research Strategies, and Future Directions in Cancers133
Global Trends in Incidence Rates of Primary Adult Liver Cancers: A Systematic Review and Meta-Analysis133
The Role of microRNAs, Long Non-coding RNAs, and Circular RNAs in Cervical Cancer131
Tumor Hypoxia: Impact on Radiation Therapy and Molecular Pathways128
Neoadjuvant Treatment in Pancreatic Cancer128
Carbon Ion Therapy: A Modern Review of an Emerging Technology127
The Role of Cancer Stem Cells in Radiation Resistance126
Integrated Multi-Omics Analyses in Oncology: A Review of Machine Learning Methods and Tools125
CAR T Cells for Acute Myeloid Leukemia: State of the Art and Future Directions124
Therapeutic Potential of Combining PARP Inhibitor and Immunotherapy in Solid Tumors119
Metabolic Reprogramming in Triple-Negative Breast Cancer113
microRNAs Biogenesis, Functions and Role in Tumor Angiogenesis112
Tumor-Induced Inflammatory Cytokines and the Emerging Diagnostic Devices for Cancer Detection and Prognosis111
The Multidisciplinary Team (MDT) Approach and Quality of Care110
Boron Neutron Capture Therapy: A Review of Clinical Applications109
NAMPT and NAPRT: Two Metabolic Enzymes With Key Roles in Inflammation109
The Crosstalk Between Tumor-Associated Macrophages (TAMs) and Tumor Cells and the Corresponding Targeted Therapy109
Mutant p53 in Cancer Progression and Targeted Therapies109
PI3K/Akt/mTOR Pathway and Its Role in Cancer Therapeutics: Are We Making Headway?108
Characterization of Hypoxia Signature to Evaluate the Tumor Immune Microenvironment and Predict Prognosis in Glioma Groups107
Mechanisms for Modulating Anoikis Resistance in Cancer and the Relevance of Metabolic Reprogramming107
The Crosstalk Between Tumor Cells and the Immune Microenvironment in Breast Cancer: Implications for Immunotherapy106
Potential Immune-Related Adverse Events Associated With Monotherapy and Combination Therapy of Ipilimumab, Nivolumab, and Pembrolizumab for Advanced Melanoma: A Systematic Review and Meta-Analysis104
Identification and Verification of Immune-Related Gene Prognostic Signature Based on ssGSEA for Osteosarcoma104
Breast Cancer Survivorship, Quality of Life, and Late Toxicities104
Blood-Brain Barrier, Blood-Brain Tumor Barrier, and Fluorescence-Guided Neurosurgical Oncology: Delivering Optical Labels to Brain Tumors103
Deep Learning for Accurate Diagnosis of Liver Tumor Based on Magnetic Resonance Imaging and Clinical Data101
Alterations of Lipid Metabolism in Cancer: Implications in Prognosis and Treatment100
Metabolic Plasticity in Chemotherapy Resistance98
Metabolic Adaptations in Cancer Stem Cells97
P-Glycoprotein: One Mechanism, Many Tasks and the Consequences for Pharmacotherapy of Cancers95
Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches92
Integrated Analysis of lncRNA–Mediated ceRNA Network in Lung Adenocarcinoma91
The Latest Battles Between EGFR Monoclonal Antibodies and Resistant Tumor Cells91
Tumor Necrosis Factor α Blockade: An Opportunity to Tackle Breast Cancer90
Role of GPX4-Mediated Ferroptosis in the Sensitivity of Triple Negative Breast Cancer Cells to Gefitinib89
Glucose Metabolism on Tumor Plasticity, Diagnosis, and Treatment89
Clinical and Biological Significances of a Ferroptosis-Related Gene Signature in Glioma89
Microbiome and Breast Cancer: New Role for an Ancient Population89
Multi-Omics Characterization of the 4T1 Murine Mammary Gland Tumor Model89
Melanoma, Melanin, and Melanogenesis: The Yin and Yang Relationship88
Artificial Convolutional Neural Network in Object Detection and Semantic Segmentation for Medical Imaging Analysis88
Psychological Distress in Outpatients With Lymphoma During the COVID-19 Pandemic87
Immune Checkpoint Inhibitors in Triple Negative Breast Cancer Treatment: Promising Future Prospects87
Proline Metabolism in Tumor Growth and Metastatic Progression87
Lactate Beyond a Waste Metabolite: Metabolic Affairs and Signaling in Malignancy87
Shaping Up the Tumor Microenvironment With Cellular Fibronectin83
An Emerging Class of Long Non-coding RNA With Oncogenic Role Arises From the snoRNA Host Genes83
Understanding Esophageal Cancer: The Challenges and Opportunities for the Next Decade83
FLT3 Mutations in Acute Myeloid Leukemia: Key Concepts and Emerging Controversies83
Delivery and Biosafety of Oncolytic Virotherapy83
Predictive Biomarkers for Checkpoint Inhibitor-Based Immunotherapy in Hepatocellular Carcinoma: Where Do We Stand?82
Has COVID-19 Affected Cancer Screening Programs? A Systematic Review82
Sexual Dimorphism in Colon Cancer81
Perplexing Role of P-Glycoprotein in Tumor Microenvironment79
Targeting SREBP-2-Regulated Mevalonate Metabolism for Cancer Therapy79
Ferroptosis in Cancer Treatment: Another Way to Rome79
Targeting Glutaminolysis: New Perspectives to Understand Cancer Development and Novel Strategies for Potential Target Therapies79
Emerging Roles of Wnt Ligands in Human Colorectal Cancer79
BTK Has Potential to Be a Prognostic Factor for Lung Adenocarcinoma and an Indicator for Tumor Microenvironment Remodeling: A Study Based on TCGA Data Mining78
IGF2BP2 Promotes Liver Cancer Growth Through an m6A-FEN1-Dependent Mechanism78
The role of BCL-2 family proteins in regulating apoptosis and cancer therapy78
Reduced Expression of METTL3 Promotes Metastasis of Triple-Negative Breast Cancer by m6A Methylation-Mediated COL3A1 Up-Regulation78
IL-6/JAK/STAT3 Signaling in Breast Cancer Metastasis: Biology and Treatment77
Obesity, Type 2 Diabetes, and Cancer Risk77
Role of DNA Methylation in the Resistance to Therapy in Solid Tumors76
A Review on Anti-Tumor Mechanisms of Coumarins76
IL-6/STAT3 Is a Promising Therapeutic Target for Hepatocellular Carcinoma76
The Role of the Transcription Factor EGR1 in Cancer75
FDA-Approved and Emerging Next Generation Predictive Biomarkers for Immune Checkpoint Inhibitors in Cancer Patients74
Macrophage and Tumor Cell Cross-Talk Is Fundamental for Lung Tumor Progression: We Need to Talk74
Immune Checkpoint Inhibitors in the Treatment of HCC73
Knowledge Domain and Emerging Trends in Ferroptosis Research: A Bibliometric and Knowledge-Map Analysis73
The Current Treatment Paradigm for Pancreatic Ductal Adenocarcinoma and Barriers to Therapeutic Efficacy73
New Blood Biomarkers for the Diagnosis of AFP-Negative Hepatocellular Carcinoma73
Global Research Trends on Prostate Diseases and Erectile Dysfunction: A Bibliometric and Visualized Study72
MiRNA and LncRNA as Potential Biomarkers in Triple-Negative Breast Cancer: A Review72
CAFs Interacting With TAMs in Tumor Microenvironment to Enhance Tumorigenesis and Immune Evasion71
Etiology of Hepatocellular Carcinoma: Special Focus on Fatty Liver Disease71
Comprehensive Review of Web Servers and Bioinformatics Tools for Cancer Prognosis Analysis71
Sintilimab: A Promising Anti-Tumor PD-1 Antibody70
A Novel Prognostic Marker Systemic Inflammation Response Index (SIRI) for Operable Cervical Cancer Patients69
Immunotherapy in Treating EGFR-Mutant Lung Cancer: Current Challenges and New Strategies69
The MOMENTUM Study: An International Registry for the Evidence-Based Introduction of MR-Guided Adaptive Therapy69
Update on the Biology, Management, and Treatment of Small Cell Lung Cancer (SCLC)69
Strategies for Targeting Gene Therapy in Cancer Cells With Tumor-Specific Promoters68
The Generation and Identity of Human Myeloid-Derived Suppressor Cells67
Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases67
m6A Reader HNRNPA2B1 Promotes Esophageal Cancer Progression via Up-Regulation of ACLY and ACC167
The Oncolytic Virus in Cancer Diagnosis and Treatment67
Lactate Modulates Cellular Metabolism Through Histone Lactylation-Mediated Gene Expression in Non-Small Cell Lung Cancer66
Metabolic Heterogeneity in Patient Tumor-Derived Organoids by Primary Site and Drug Treatment66
RNA-Seq Profiling of Serum Exosomal Circular RNAs Reveals Circ-PNN as a Potential Biomarker for Human Colorectal Cancer65
Changing Technologies of RNA Sequencing and Their Applications in Clinical Oncology65
EBV-Positive Gastric Cancer: Current Knowledge and Future Perspectives65
METTL3 Promotes the Progression of Gastric Cancer via Targeting the MYC Pathway65
Tumor Suppressor miRNA in Cancer Cells and the Tumor Microenvironment: Mechanism of Deregulation and Clinical Implications65
Naturally-Occurring Canine Mammary Tumors as a Translational Model for Human Breast Cancer65
A Review of Newly Diagnosed Glioblastoma65
Biomarkers of Checkpoint Inhibitor Induced Immune-Related Adverse Events—A Comprehensive Review64
The Mechanism of Warburg Effect-Induced Chemoresistance in Cancer64
Obesity and Breast Cancer: A Paradoxical and Controversial Relationship Influenced by Menopausal Status64
An Inflammatory Response-Related Gene Signature Can Impact the Immune Status and Predict the Prognosis of Hepatocellular Carcinoma64
Cancer in Africa: The Untold Story64
Identification of Therapeutic Targets and Prognostic Biomarkers Among CXC Chemokines in the Renal Cell Carcinoma Microenvironment64
PIK3CA Mutations as a Molecular Target for Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer64
FOXM1 and Cancer: Faulty Cellular Signaling Derails Homeostasis64
Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death64
Humanized Rodent Models for Cancer Research64
Salivary Gland Carcinoma: Novel Targets to Overcome Treatment Resistance in Advanced Disease63
MYCN Function in Neuroblastoma Development63
Metabolic Plasticity of Melanoma Cells and Their Crosstalk With Tumor Microenvironment63
YTHDF1 Is a Potential Pan-Cancer Biomarker for Prognosis and Immunotherapy63
CAR-NK Cell: A New Paradigm in Tumor Immunotherapy62
Cancer Stem Cells as a Potential Target to Overcome Multidrug Resistance62
Current Understanding of the Mechanisms Underlying Immune Evasion From PD-1/PD-L1 Immune Checkpoint Blockade in Head and Neck Cancer62
Current Triple-Negative Breast Cancer Subtypes: Dissecting the Most Aggressive Form of Breast Cancer61
Systemic Reprogramming of Monocytes in Cancer61
Tumor Associated Macrophages: Origin, Recruitment, Phenotypic Diversity, and Targeting61
Osteosarcoma and Metastasis61
Theranostic Pretargeting Drug Delivery and Imaging Platforms in Cancer Precision Medicine60
Fibroblast Activation Protein-α as a Target in the Bench-to-Bedside Diagnosis and Treatment of Tumors: A Narrative Review60
The Metabolic Mechanisms of Breast Cancer Metastasis60
CCL2: An Important Mediator Between Tumor Cells and Host Cells in Tumor Microenvironment60
The Mevalonate Pathway, a Metabolic Target in Cancer Therapy60
CAR T-Cells in Multiple Myeloma: State of the Art and Future Directions60
Immunotherapy in Acute Myeloid Leukemia: Where We Stand59
Immunotherapy in Malignant Pleural Mesothelioma59
Clinical and Pharmacologic Differences of CDK4/6 Inhibitors in Breast Cancer59
CDK9: A Comprehensive Review of Its Biology, and Its Role as a Potential Target for Anti-Cancer Agents59
Significance of Tumor Mutation Burden in Immune Infiltration and Prognosis in Cutaneous Melanoma59
Traditional Classification and Novel Subtyping Systems for Bladder Cancer59
Targeted Therapies and Biomarkers in Small Cell Lung Cancer59
CAR T-Cell Therapy for B-Cell non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia: Clinical Trials and Real-World Experiences59
The Landscape of Immune Cells Infiltrating in Prostate Cancer59
Pyroptosis-Related Gene Signatures Can Robustly Diagnose Skin Cutaneous Melanoma and Predict the Prognosis58
Analysis of N6-Methyladenosine Methyltransferase Reveals METTL14 and ZC3H13 as Tumor Suppressor Genes in Breast Cancer58
The Role of Cystine/Glutamate Antiporter SLC7A11/xCT in the Pathophysiology of Cancer58
Clinical Perspective of FDA Approved Drugs With P-Glycoprotein Inhibition Activities for Potential Cancer Therapeutics58
Reciprocal Interplay Between Fibrillar Collagens and Collagen-Binding Integrins: Implications in Cancer Progression and Metastasis58
From Immunogenic Cell Death to Immunogenic Modulation: Select Chemotherapy Regimens Induce a Spectrum of Immune-Enhancing Activities in the Tumor Microenvironment58
Cross-Talk Between the Tumor Microenvironment, Extracellular Matrix, and Cell Metabolism in Cancer57
Meningioma: A Review of Clinicopathological and Molecular Aspects57
Vascular Resection for Pancreatic Cancer: 2019 French Recommendations Based on a Literature Review From 2008 to 6-201957
Long Non-coding RNA MIR4435-2HG Promotes Colorectal Cancer Proliferation and Metastasis Through miR-206/YAP1 Axis57
Oncogenic Role of PVT1 and Therapeutic Implications57
Concurrent Genetic Alterations and Other Biomarkers Predict Treatment Efficacy of EGFR-TKIs in EGFR-Mutant Non-Small Cell Lung Cancer: A Review57
A Potential Mechanism of Temozolomide Resistance in Glioma–Ferroptosis56
Computational Oncology in the Multi-Omics Era: State of the Art56
Circulating Tumor DNA and Minimal Residual Disease (MRD) in Solid Tumors: Current Horizons and Future Perspectives56
LPAR1, Correlated With Immune Infiltrates, Is a Potential Prognostic Biomarker in Prostate Cancer56
A Potential Role of YAP/TAZ in the Interplay Between Metastasis and Metabolic Alterations56
Genome-Wide Sex and Gender Differences in Cancer56
The Interaction Between lncRNA SNHG6 and hnRNPA1 Contributes to the Growth of Colorectal Cancer by Enhancing Aerobic Glycolysis Through the Regulation of Alternative Splicing of PKM55
Research Progress of TXNIP as a Tumor Suppressor Gene Participating in the Metabolic Reprogramming and Oxidative Stress of Cancer Cells in Various Cancers55
FLASH Radiotherapy: History and Future55
m5C RNA Methylation Regulators Predict Prognosis and Regulate the Immune Microenvironment in Lung Squamous Cell Carcinoma55
Targeting Epstein-Barr Virus in Nasopharyngeal Carcinoma55
Targeting CXCR4 in AML and ALL55
Probiotics in Cancer54
Progress and Future Trends in PET/CT and PET/MRI Molecular Imaging Approaches for Breast Cancer54
Dysregulated m6A-Related Regulators Are Associated With Tumor Metastasis and Poor Prognosis in Osteosarcoma54
Insulin Growth Factor Binding Protein 7 (IGFBP7)-Related Cancer and IGFBP3 and IGFBP7 Crosstalk53
The Era of Radiogenomics in Precision Medicine: An Emerging Approach to Support Diagnosis, Treatment Decisions, and Prognostication in Oncology53
5-Fluorouracil: A Narrative Review on the Role of Regulatory Mechanisms in Driving Resistance to This Chemotherapeutic Agent53
The Burden and Trends of Breast Cancer From 1990 to 2017 at the Global, Regional, and National Levels: Results From the Global Burden of Disease Study 201753
Machine Learning-Based Models for Prediction of Toxicity Outcomes in Radiotherapy53
Genomics and Prognosis Analysis of Epithelial-Mesenchymal Transition in Glioma53
Glioblastoma Organoids: Pre-Clinical Applications and Challenges in the Context of Immunotherapy53
Artificial Intelligence (AI)-Based Systems Biology Approaches in Multi-Omics Data Analysis of Cancer53
Broad Spectrum Deubiquitinase Inhibition Induces Both Apoptosis and Ferroptosis in Cancer Cells53
The Role of Iron in Cancer Progression52
The Lipid Metabolic Landscape of Cancers and New Therapeutic Perspectives52
Inhibition of Fatty Acid Synthase Upregulates Expression of CD36 to Sustain Proliferation of Colorectal Cancer Cells52
Immunotherapy for Head and Neck Cancer: A Paradigm Shift From Induction Chemotherapy to Neoadjuvant Immunotherapy52
68Ga-FAPI-04 Versus 18F-FDG PET/CT in the Detection of Hepatocellular Carcinoma52
Stroma-Targeting Therapy in Pancreatic Cancer: One Coin With Two Sides?52
Primary Cutaneous B-Cell Lymphomas: An Update52
MR-Guided Radiotherapy for Prostate Cancer51
When the Loss Costs Too Much: A Systematic Review and Meta-Analysis of Sarcopenia in Head and Neck Cancer51
Identification of Hub Genes Associated With Development of Head and Neck Squamous Cell Carcinoma by Integrated Bioinformatics Analysis51
Patient-Derived Cancer Organoids as Predictors of Treatment Response51
Starting a Fire Without Flame: The Induction of Cell Death and Inflammation in Electroporation-Based Tumor Ablation Strategies51
Estrogen Receptor Beta (ERβ): A Ligand Activated Tumor Suppressor51
Targeting Hypoxia: Hypoxia-Activated Prodrugs in Cancer Therapy51
LncRNA-Encoded Peptide: Functions and Predicting Methods51
The Role of CD276 in Cancers51
Induction of Pyroptosis: A Promising Strategy for Cancer Treatment51
A Review on Application of Deep Learning Algorithms in External Beam Radiotherapy Automated Treatment Planning50
Roles of microRNAs in Ovarian Cancer Tumorigenesis: Two Decades Later, What Have We Learned?50
Platelets and Metastasis: New Implications of an Old Interplay50
An Overview of Vasculogenic Mimicry in Breast Cancer50
Extracellular Matrix Stiffness: New Areas Affecting Cell Metabolism50
Tumor Mutational Burden Determined by Panel Sequencing Predicts Survival After Immunotherapy in Patients With Advanced Gastric Cancer50
Circulating Tumor DNA as a Prognostic Biomarker in Localized Non-small Cell Lung Cancer50
Identification of a Ferroptosis-Related LncRNA Signature as a Novel Prognosis Model for Lung Adenocarcinoma50
Development of EGFR TKIs and Options to Manage Resistance of Third-Generation EGFR TKI Osimertinib: Conventional Ways and Immune Checkpoint Inhibitors50
Cholesterol Metabolic Reprogramming in Cancer and Its Pharmacological Modulation as Therapeutic Strategy50
VCAM1 Promotes Tumor Cell Invasion and Metastasis by Inducing EMT and Transendothelial Migration in Colorectal Cancer49
Targeting Pyrimidine Metabolism in the Era of Precision Cancer Medicine49
Escape From Treatment; the Different Faces of Leukemic Stem Cells and Therapy Resistance in Acute Myeloid Leukemia49
Evolution of Experimental Models in the Study of Glioblastoma: Toward Finding Efficient Treatments49
Management of Cancer Cachexia: Attempting to Develop New Pharmacological Agents for New Effective Therapeutic Options49
Making a Cold Tumor Hot: The Role of Vaccines in the Treatment of Glioblastoma49
The Role of Gut Barrier Dysfunction and Microbiome Dysbiosis in Colorectal Cancer Development49
Cancer-Associated Fibroblasts and Tumor-Associated Macrophages in Cancer and Cancer Immunotherapy49
Actors on the Scene: Immune Cells in the Myeloma Niche49
The Endosteal Niche in Breast Cancer Bone Metastasis49
Association of Immune Related Adverse Events With Efficacy of Immune Checkpoint Inhibitors and Overall Survival in Cancers: A Systemic Review and Meta-analysis49
GLI1: A Therapeutic Target for Cancer48
A Prognostic Nomogram Combining Immune-Related Gene Signature and Clinical Factors Predicts Survival in Patients With Lung Adenocarcinoma48
PPAR-α Modulators as Current and Potential Cancer Treatments48
miR-15b-5p Promotes Growth and Metastasis in Breast Cancer by Targeting HPSE248
Impact of Rehabilitation on Breast Cancer Related Fatigue: A Pilot Study48
Cyclooxygenase-2 Inhibitor: A Potential Combination Strategy With Immunotherapy in Cancer48
Immunosuppression in Glioblastoma: Current Understanding and Therapeutic Implications48
Hepatic Arterial Infusion Chemotherapy Combined With PD-1 Inhibitors Plus Lenvatinib Versus PD-1 Inhibitors Plus Lenvatinib for Advanced Hepatocellular Carcinoma48
Emerging Role of Circular RNAs in Cancer48
Deregulation of Lipid Metabolism: The Critical Factors in Ovarian Cancer47
Heterogeneity of TP53 Mutations and P53 Protein Residual Function in Cancer: Does It Matter?47
The Engagement Between MDSCs and Metastases: Partners in Crime47
Sirt4: A Multifaceted Enzyme at the Crossroads of Mitochondrial Metabolism and Cancer47
The Resistance Mechanisms and Treatment Strategies for ALK-Rearranged Non-Small Cell Lung Cancer47
PD-L1 Expression in Glioblastoma, the Clinical and Prognostic Significance: A Systematic Literature Review and Meta-Analysis47
PI(3,4)P2 Signaling in Cancer and Metabolism47
High Expression of FAP in Colorectal Cancer Is Associated With Angiogenesis and Immunoregulation Processes47
Mouse Tumor-Bearing Models as Preclinical Study Platforms for Oral Squamous Cell Carcinoma47
A Bump in the Road: How the Hostile AML Microenvironment Affects CAR T Cell Therapy47
Platelet-Cancer Interplay: Molecular Mechanisms and New Therapeutic Avenues46
More Than a Metabolic Enzyme: MTHFD2 as a Novel Target for Anticancer Therapy?46
Acetyl-CoA Carboxylases and Diseases46
An Original Ferroptosis-Related Gene Signature Effectively Predicts the Prognosis and Clinical Status for Colorectal Cancer Patients46
Understanding Sources of Variation to Improve the Reproducibility of Radiomics46
Proteomic Profiling of Serum Exosomes From Patients With Metastatic Gastric Cancer46
CXCR4 and CXCR7 Signaling Pathways: A Focus on the Cross-Talk Between Cancer Cells and Tumor Microenvironment46
Single-Cell Transcriptomics Reveals the Complexity of the Tumor Microenvironment of Treatment-Naive Osteosarcoma46
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