OOIR: Observatory of International Research

Papers

(The H4-Index of Frontiers in Oncology is 77. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis	248
CRISPR Gene Therapy: Applications, Limitations, and Implications for the Future	232
EMT Factors and Metabolic Pathways in Cancer	195
Tumor-Associated Macrophages in Human Breast, Colorectal, Lung, Ovarian and Prostate Cancers	186
Hypoxia-Induced Epithelial-Mesenchymal Transition in Cancers: HIF-1α and Beyond	166
Nanobodies: Next Generation of Cancer Diagnostics and Therapeutics	161
Tumor Microenvironment: Extracellular Matrix Alterations Influence Tumor Progression	152
Mechanisms of Cancer Resistance to Immunotherapy	149
Chronic Stress Promotes Cancer Development	148
Disialoganglioside GD2 Expression in Solid Tumors and Role as a Target for Cancer Therapy	148
The Double-Edge Sword of Autophagy in Cancer: From Tumor Suppression to Pro-tumor Activity	147
Altered Iron Metabolism and Impact in Cancer Biology, Metastasis, and Immunology	142
Long Non-Coding RNAs: The Regulatory Mechanisms, Research Strategies, and Future Directions in Cancers	140
Tumor Hypoxia: Impact on Radiation Therapy and Molecular Pathways	131
Integrated Multi-Omics Analyses in Oncology: A Review of Machine Learning Methods and Tools	129
CAR T Cells for Acute Myeloid Leukemia: State of the Art and Future Directions	126
Therapeutic Potential of Combining PARP Inhibitor and Immunotherapy in Solid Tumors	124
The Multidisciplinary Team (MDT) Approach and Quality of Care	121
PI3K/Akt/mTOR Pathway and Its Role in Cancer Therapeutics: Are We Making Headway?	121
Tumor-Induced Inflammatory Cytokines and the Emerging Diagnostic Devices for Cancer Detection and Prognosis	120
Metabolic Reprogramming in Triple-Negative Breast Cancer	116
microRNAs Biogenesis, Functions and Role in Tumor Angiogenesis	116
Breast Cancer Survivorship, Quality of Life, and Late Toxicities	115
Boron Neutron Capture Therapy: A Review of Clinical Applications	114
Mutant p53 in Cancer Progression and Targeted Therapies	113

The Crosstalk Between Tumor-Associated Macrophages (TAMs) and Tumor Cells and the Corresponding Targeted Therapy	112
The Crosstalk Between Tumor Cells and the Immune Microenvironment in Breast Cancer: Implications for Immunotherapy	112
NAMPT and NAPRT: Two Metabolic Enzymes With Key Roles in Inflammation	112
Mechanisms for Modulating Anoikis Resistance in Cancer and the Relevance of Metabolic Reprogramming	111
Identification and Verification of Immune-Related Gene Prognostic Signature Based on ssGSEA for Osteosarcoma	108
Characterization of Hypoxia Signature to Evaluate the Tumor Immune Microenvironment and Predict Prognosis in Glioma Groups	107
Blood-Brain Barrier, Blood-Brain Tumor Barrier, and Fluorescence-Guided Neurosurgical Oncology: Delivering Optical Labels to Brain Tumors	107
Deep Learning for Accurate Diagnosis of Liver Tumor Based on Magnetic Resonance Imaging and Clinical Data	106
Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches	104
Metabolic Plasticity in Chemotherapy Resistance	103
Alterations of Lipid Metabolism in Cancer: Implications in Prognosis and Treatment	102
Metabolic Adaptations in Cancer Stem Cells	99
P-Glycoprotein: One Mechanism, Many Tasks and the Consequences for Pharmacotherapy of Cancers	99
Melanoma, Melanin, and Melanogenesis: The Yin and Yang Relationship	95
The Latest Battles Between EGFR Monoclonal Antibodies and Resistant Tumor Cells	94
Clinical and Biological Significances of a Ferroptosis-Related Gene Signature in Glioma	93
Integrated Analysis of lncRNA–Mediated ceRNA Network in Lung Adenocarcinoma	93
Artificial Convolutional Neural Network in Object Detection and Semantic Segmentation for Medical Imaging Analysis	92
Glucose Metabolism on Tumor Plasticity, Diagnosis, and Treatment	92
Role of GPX4-Mediated Ferroptosis in the Sensitivity of Triple Negative Breast Cancer Cells to Gefitinib	92
Tumor Necrosis Factor α Blockade: An Opportunity to Tackle Breast Cancer	92
Immune Checkpoint Inhibitors in Triple Negative Breast Cancer Treatment: Promising Future Prospects	91
Multi-Omics Characterization of the 4T1 Murine Mammary Gland Tumor Model	90
The role of BCL-2 family proteins in regulating apoptosis and cancer therapy	90
Lactate Beyond a Waste Metabolite: Metabolic Affairs and Signaling in Malignancy	88
Proline Metabolism in Tumor Growth and Metastatic Progression	88
FLT3 Mutations in Acute Myeloid Leukemia: Key Concepts and Emerging Controversies	87
Understanding Esophageal Cancer: The Challenges and Opportunities for the Next Decade	87
Psychological Distress in Outpatients With Lymphoma During the COVID-19 Pandemic	87
An Emerging Class of Long Non-coding RNA With Oncogenic Role Arises From the snoRNA Host Genes	86
Shaping Up the Tumor Microenvironment With Cellular Fibronectin	85
Sexual Dimorphism in Colon Cancer	85
IL-6/JAK/STAT3 Signaling in Breast Cancer Metastasis: Biology and Treatment	85
A Review on Anti-Tumor Mechanisms of Coumarins	84
Has COVID-19 Affected Cancer Screening Programs? A Systematic Review	84
Delivery and Biosafety of Oncolytic Virotherapy	83
Predictive Biomarkers for Checkpoint Inhibitor-Based Immunotherapy in Hepatocellular Carcinoma: Where Do We Stand?	82
Ferroptosis in Cancer Treatment: Another Way to Rome	82
IL-6/STAT3 Is a Promising Therapeutic Target for Hepatocellular Carcinoma	82
Perplexing Role of P-Glycoprotein in Tumor Microenvironment	82
IGF2BP2 Promotes Liver Cancer Growth Through an m6A-FEN1-Dependent Mechanism	81
Emerging Roles of Wnt Ligands in Human Colorectal Cancer	81
Targeting SREBP-2-Regulated Mevalonate Metabolism for Cancer Therapy	81
FDA-Approved and Emerging Next Generation Predictive Biomarkers for Immune Checkpoint Inhibitors in Cancer Patients	80
Reduced Expression of METTL3 Promotes Metastasis of Triple-Negative Breast Cancer by m6A Methylation-Mediated COL3A1 Up-Regulation	80
Obesity, Type 2 Diabetes, and Cancer Risk	80
The Role of the Transcription Factor EGR1 in Cancer	80
BTK Has Potential to Be a Prognostic Factor for Lung Adenocarcinoma and an Indicator for Tumor Microenvironment Remodeling: A Study Based on TCGA Data Mining	79
Targeting Glutaminolysis: New Perspectives to Understand Cancer Development and Novel Strategies for Potential Target Therapies	79
Knowledge Domain and Emerging Trends in Ferroptosis Research: A Bibliometric and Knowledge-Map Analysis	78

Global Research Trends on Prostate Diseases and Erectile Dysfunction: A Bibliometric and Visualized Study	78
The Current Treatment Paradigm for Pancreatic Ductal Adenocarcinoma and Barriers to Therapeutic Efficacy	78