OOIR: Observatory of International Research

Papers

(The median citation count of Asian Pacific Journal of Tropical Biomedicine is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Anti-viral and anti-inflammatory effects of kaempferol and quercetin and COVID-2019	40
Naringin attenuates oxidative stress, inflammation, apoptosis, and oxidative DNA damage in acrylamide-induced nephrotoxicity in rats	21
Anti-inflammatory, anti-oxidative and anti-apoptotic effects of Heracleum persicum L. extract on rats with gentamicin-induced nephrotoxicity	20
Pharmacological aspects of fisetin	15
Antibacterial activity and inhibition against Staphylococcus aureus NorA efflux pump by ferulic acid and its esterified derivatives	15
Hexadecanoic acid-enriched extract of Halymenia durvillei induces apoptotic and autophagic death of human triple-negative breast cancer cells by upregulating ER stress	12
Nanoemulsion containing a synergistic combination of curcumin and quercetin for nose-to-brain delivery	11
Chemical constituents and biological activities of essential oils of Amomum genus (Zingiberaceae)	10
Phytochemical analysis of Berberis lyceum methanolic extract and its antiviral activity through the restoration of MAPK signaling pathway modulated by HCV NS5A	10
Antioxidant and antigenotoxic properties of Alpinia galanga, Curcuma amada, and Curcuma caesia	9
Antioxidant, antimicrobial, and α-glucosidase inhibitory activities of saponin extracts from walnut (Juglans regia L.) leaves	9
Harpephyllum caffrum stimulates glucose uptake, abates redox imbalance and modulates purinergic and glucogenic enzyme activities in oxidative hepatic injury	8
Phytosomal curcumin alleviates collagen-induced arthritis by downregulating Th17 and upregulating Treg cell responses in rats	8
Antidepressant and anti-nociceptive effects of Nigella sativa and its main constituent, thymoquinone	8
p-Coumaric acid alleviates adriamycin-induced hepatotoxicity in rats	8
Scopoletin	8
Piperine suppresses growth and migration of human breast cancer cells through attenuation of Rac1 expression	8
Natural compounds as potential inhibitors of SARS-CoV-2 main protease	8
Biopeptides of Pyropia yezoensis and their potential health benefits	7
Synergistic effect of flavonoids combined with antivenom on neutralisation of Naja naja venom	7
Salsola imbricata Forssk. ameliorates acetic acid-induced inflammatory bowel disease by modulating dysregulated antioxidant enzyme system and cytokine signaling pathways in mice	7
Ginseng ameliorates pulmonary toxicity induced by silicon dioxide nanoparticles in rats	7
Aloin attenuates chronic constriction injury-induced neuropathic pain in rats by inhibiting inflammatory cytokines and oxidative stress	7
Prodigiosin from Serratia	7
Protein extract of kenaf seed exhibits anticoagulant, antiplatelet and antioxidant activities	6

Celastrus paniculatus oil ameliorates synaptic plasticity in a rat model of attention deficit hyperactivity disorder	6
Effect of Thunbergia laurifolia water extracts on hepatic insulin resistance in high-fat diet-induced obese mice	6
Gum resin extract of Boswellia serrata attenuates lipopolysaccharide-induced inflammation and oxidative damage in hepatic and renal tissues of rats	6
Caffeic acid and protocatechuic acid modulate Nrf2 and inhibit Ehrlich ascites carcinomas in mice	6
Morin attenuates L-arginine induced acute pancreatitis in rats by downregulating myeloperoxidase and lipid peroxidation	6
Anticancer drug screening of natural products	6
Potential of polyphenols in curbing quorum sensing and biofilm formation in Gram-negative pathogens	6
Hepato- and reno-protective effects of thymoquinone, crocin, and carvacrol	6
Phytochemicals, pharmacological and ethnomedicinal studies of Artocarpus	6
Gracilaria fisheri oligosaccharides ameliorate inflammation and colonic epithelial barrier dysfunction in mice with acetic acid-induced colitis	5
Improved performance of naringenin herbosomes over naringenin in streptozotocin-induced diabetic rats	5
Tylophora hirsuta L. leaf extract attenuates alloxan-induced diabetes in mice by suppressing oxidative stress and α-amylase	5
Anti-obesity effect and UHPLC-QTOF-MS/MS based metabolite profiling of Solanum nigrum leaf extract	5
Borassus flabellifer L. crude male flower extracts alleviate cisplatin-induced oxidative stress in rat kidney cells	5
Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in rats	5
Non-alcoholic fatty liver disease	5
Myricetin alleviates ovalbumin-induced allergic rhinitis in mice by regulating Th1/Th2 balance	5
Antiglycation, antioxidant, antiacne, and photoprotective activities of crude extracts and triterpene saponin fraction of Sapindus saponaria L. fruits	5
Enhancing pharmaceutical potential and oral bioavailability of Allium cepa nanosuspension in male albino rats using response surface methodology	4
Identification of climatic and environmental factors associated with incidence of cutaneous leishmaniasis in Central Iran using satellite imagery	4
Anti-leishmanial, immunomodulatory and anti-oxidative activity of quercetin against cutaneous leishmaniasis caused by Leishmania major	4
Anti-tumor effects and cellular mechanisms of Pistacia atlantica methanolic extract against Ehrlich solid tumor in mice	4
Valencene-rich fraction from Vetiveria zizanioides exerts immunostimulatory effects in vitro and in mice	4
Rhus longipes (Engl.) infusions improve glucose metabolism and mitigate oxidative biomarkers in ferrous sulfate-induced renal injury	4
Phloretin-induced suppression of oxidative and nitrosative stress attenuates doxorubicin-induced cardiotoxicity in rats	4
Aqueous extract of freeze-dried Protaetia brevitarsis larvae promotes osteogenesis by activating β-catenin signaling	4
Molluscicidal effect of green synthesized silver nanoparticles using Azadirachta indica on Biomphalaria alexandrina snails and Schistosoma mansoni cercariae	4
Natural sources, biosynthesis, biological functions, and molecular mechanisms of shikimic acid and its derivatives	4
Biosensors	4
Humulus japonicus extract alleviates oxidative stress and apoptosis in 6-hydroxydopamine-induced PC12 cells	4
Role of flaxseed (Linum usitatissimum L.) in disease prevention and treatment	4
Bitter gourd extract improves glucose homeostasis and lipid profile via enhancing insulin signaling in the liver and skeletal muscles of diabetic rats	4
Antimicrobial activities of Acacia genus	3
Human Wharton's jelly mesenchymal stem cells inhibit cytokine storm in acute respiratory distress syndrome in a rat model	3
Sang-Yod rice bran hydrolysates alleviate hypertension, endothelial dysfunction, vascular remodeling, and oxidative stress in nitric oxide deficient hypertensive rats	3
Origanum vulgare L. leaf extract alleviates finasteride-induced oxidative stress in mouse liver and kidney	3
Phytochemical composition and toxicity assessment of Ammi majus L.	3
Protective effects of rice bran hydrolysates on heart rate variability, cardiac oxidative stress, and cardiac remodeling in high fat and high fructose diet-fed rats	3
In vitro antimicrobial and synergistic effect of essential oil from the red macroalgae Centroceras clavulatum (C. Agardh) Montagne with conventional antibiotics	3
Apoptotic and cytostatic actions of maslinic acid in colorectal cancer cells through possible IKK-β inhibition	3
Network pharmacology-based analysis of effective components and mechanism of Rhizoma coptidis in treating diabetes	3
Anti-tumor activity of rice bran hydrolysates on migration, invasion and angiogenesis	3
Antioxidant, cytotoxic, and anti-venom activity of Alstonia parvifolia Merr. Bark	3
Crotalaria ferruginea extract attenuates lipopolysaccharide-induced acute lung injury in mice by inhibiting MAPK/NF-κB signaling pathways	3
Screening of phytocompounds, molecular docking studies, and in vivo anti-inflammatory activity of heartwood aqueous extract of Pterocarpus santalinus L.f.	3
Anti-senescence and anti-wrinkle activities of 3—bromo—4,5—dihydroxybenzaldehyde from Polysiphonia morrowii Harvey in human dermal fibroblasts	3
Anti-angiogenesis and anti-inflammatory effects of Moringa oleifera leaf extract in the early stages of streptozotocin-induced diabetic nephropathy in rats	3
In-silico and in-vitro evaluation of docetaxel and berberine as potential p53 modulating apoptotic inducers in oral squamous cell carcinoma	3
Fucoxanthin suppresses OxLDL-induced inflammation via activation of Nrf2 and inhibition of NF-κB signaling	3
Immunostimulatory role of rBmHSP60 from filarial parasite Brugia malayi	2

Hepatoprotective effect of date palm fruit extract against doxorubicin intoxication in Wistar rats	2
Natural polysaccharides for ulcerative colitis	2
In vitro antioxidant and wound healing activity of Sargassum polycystum hydroethanolic extract in fibroblasts and keratinocytes	2
Methyl gallate isolated from Mangifera pajang kernel induces proliferation inhibition and apoptosis in MCF-7 breast cancer cells via oxidative stress	2
Voacanga grandifolia (Miq.) Rolfe protects against alcohol-induced liver toxicity in rats	2
Plant-derived natural compounds in the treatment of arsenic-induced toxicity	2
Melatonin alleviates oxidative stress, inflammation, apoptosis, and DNA damage in acrylamide–induced nephrotoxicity in rats	2
Ethanol extract of Chondracanthus tenellus (Harvey) Hommersand attenuates lipopolysaccharide-induced inflammatory and oxidative response by blocking the NF-κB, MAPKs, and PI3K/Akt signaling pathways	2
CRX-527 as a candidate adjuvant in a recombinant BCG-based malaria vaccine	2
Caraway extract alleviates atopic dermatitis by regulating oxidative stress, suppressing Th2 cells, and upregulating Th1 cells in mice	2
Reactive oxygen species and senescence modulatory effects of rice bran extract on 4T1 and NIH-3T3 cells co-treatment with doxorubicin	2
Quercetin modulates ovarian autophagy–related molecules and stereological parameters in a rat model of PCOS	2
Kaempferol and its derivatives: Biological activities and therapeutic potential	2
Nebulized Mycobacterium vaccae protects against asthma by attenuating the imbalance of IRF4/IRF8 expression in dendritic cells	2
β-Islet cell regeneration potential of Mirabilis jalapa in hyperglycemic rats	2
Mechanisms of medicinal plants in the treatment of diabetic wound	2
Anthrahydroquinone-2,6-disulfonate alleviates paraquat-induced kidney injury via the apelin-APJ pathway in rats	2
Metabolomics in drug discovery: Restoring antibiotic pipeline	2
Corchorus olitorius aqueous extract attenuates quorum sensing-regulated virulence factor production and biofilm formation	2
Lipid-lowering effect of Oroxylum indicum (L.) Kurz extract in hyperlipidemic mice	2
Barrientosiimonas humi ethyl acetate extract exerts cytotoxicity against MCF-7 and MDA-MB-231 cells via induction of apoptosis and cell cycle arrest	2
In vitro anti-melanoma effect of polyphenolic compounds	2
Persea americana attenuates inflammatory response associated with hyperlipidemia in ovariectomized and irradiated rats by regulating MMP-3/TIMP-1 levels	2
Recent advances on pathogenesis, diagnosis, prevention, immunological aspects, and vectors of dengue: A review	2
Inhibition mechanisms of secretome proteins from Paenibacillus polymyxa Kp10 and Lactococcus lactis Gh1 against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus	2
Dehydroabietic acid chemosensitizes drug-resistant acute lymphoblastic leukemia cells by downregulating survivin expression	2
Anticancer activity of Δ9-tetrahydrocannabinol and cannabinol in vitro and in human lung cancer xenograft	2
Epigallocatechin-3-gallate exerts antihypertensive effects and improves endothelial function in spontaneously hypertensive rats	2
Dieckol isolated from Eisenia bicyclis extract suppresses RANKL-induced osteoclastogenesis in murine RAW 264.7 cells	1
Demethylbelamcandaquinone B from Marantodes pumilum var. alata (Blume) Kuntze inhibits osteoclast differentiation in RAW264.7 cells	1
Cannabinoid CB2receptors and spinal microglia are implicated in tingenone-mediated antinociception in mice	1
Anti-inflammatory effects of Solanum procumbens on a low dose complete Freund's adjuvant-induced arthritis rat model	1
Ethyl acetate extract of Smilax glabra Roxb roots and its major active compound astilbin promote osteoblastogenesis in vitro by upregulating bone cell differentiation- associated genes	1
Astragalus adscendens extract shows antidiabetic effects through controlling oxidative stress, inflammation and apoptosis in streptozotocin-induced diabetic rats	1
Macrophage-secreted exosomes inhibit breast cancer cell migration via the miR- 101-3p/DLG5 axis	1
Midkine ameliorates LPS-induced apoptosis of airway smooth muscle cells via the Notch2 pathway	1
Molluscicidal activities of green-synthesized Alstonia congensis silver nanoparticles	1
Hydroxysafflor yellow A protects against thioacetamide-induced liver fibrosis in rats via suppressing proinflammatory/fibrogenic mediators and promoting hepatic stellate cell senescence and apoptosis	1
Salidroside attenuates oxygen and glucose deprivation-induced neuronal injury by inhibiting ferroptosis	1
Ethanol extract of Abelmoschus manihot suppresses endoplasmic reticulum stress in contrast-induced nephropathy	1
Colon cancer and their targeting approaches through nanocarriers	1
Anti-inflammatory and antipyretic potential of Arbutus andrachne L. methanolic leaf extract in rats	1
Total flavonoids from Saussurea involucrata attenuate inflammation in lipopolysaccharide-stimulated RAW264.7 macrophages via modulating p65, c-Jun, and IRF3 signaling pathways	1
Agmatine ameliorates diabetes type 2-induced nephropathy in rats	1
Lentinula edodes extract inhibits matrix metalloproteinase expression and increases type I procollagen expression via the p38 MAPK/c-Fos signaling pathway in ultraviolet A and B-irradiated HaCaT kerat	1
Beta-glucan protects against isoproterenol-induced cardiac remodeling by regulating the ACE-AT1R axis and attenuates cardiac inflammation and apoptosis	1
Combinatorial effect of diclofenac with piperine and D-limonene on inducing apoptosis and cell cycle arrest of breast cancer cells	1
Honokiol attenuates oxidative stress-induced cytotoxicity in human keratinocytes via activating AMPK signaling	1
Analgesic and anti-inflammatory activity of Cotinus coggygria Scop. extracts in vivo	1
Characterization and antimicrobial, antioxidant, and anti-proliferative activities of green synthesized magnesium oxide nanoparticles with shoot extracts of Plicosepalus curviflorus	1
Biological functions and diagnostic implications of microRNAs in Mycobacterium tuberculosis infection	1
Cytotoxic effects of Thai noni juice product ethanolic extracts against cholangiocarcinoma cell lines	1
L-carvone attenuates myocardial injury and dyslipidemia in rats with isoproterenolinduced cardiac hypertrophy	1
Zinc oxide nanoparticles accelerate the healing of methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds in rabbits	1
Essential oil from Saussurea costus inhibits proliferation and migration of Eca109 cells via mitochondrial apoptosis and STAT3 signaling	1
Syringic acid induces cancer cell death in the presence of Cu (II) ions via pro-oxidant activity	1
Cardioprotective effects of Pinus eldarica bark extract on adrenaline-induced myocardial infarction in rats	1
Chrysanthemum indicum ethanol extract attenuates hepatic stellate cell activation in vitro and thioacetamide-induced hepatofibrosis in rats	1
Cardiovascular protective properties of gastrodin	1
New trends in pharmacological treatment of acute kidney injury	1
Antiviral activity of mangiferin from the rhizome of Anemarrhena asphodeloides against herpes simplex virus type 1	1
An in vitro and in silico study of anti-dermatophytic activity of gossypol from fruits of Thespesia populnea (L.) Sol. ex Correa	1
Glinus lotoides ethanolic extract alleviates LPS-induced anxiety and depression-like behavior by modulating antioxidant and inflammatory biomarkers in rats	1
Interleukin-33 exerts pleiotropic immunoregulatory effects in response to Plasmodium berghei ANKA (PbA) infection in mice	1
Ardisia gigantifolia ethanolic extract inhibits cell proliferation and targets cancer stem cells in gastric cancer	1
Potential immunomodulatory role of sesamin in combating immune dysregulation associated with COVID-19	1
Ellagic acid inhibits gastric cancer cells by modulating oxidative stress and inducing apoptosis	1
Analgesic-like activity of perillyl acetate	1
Senna petersiana inhibits key digestive enzymes and modulates dysfunctional enzyme activities in oxidative pancreatic injury	1
Ethyl acetate fraction of Sargassum pallidum extract attenuates particulate matterinduced oxidative stress and inflammation in keratinocytes and zebrafish	1
Naringenin suppresses NLRP3 inflammasome activation via the mRNA-208a signaling pathway in isoproterenol-induced myocardial infarction	1
Nigella sativa oil alleviates doxorubicin-induced cardiomyopathy and neurobehavioral changes in mice	1