OOIR: Observatory of International Research

Papers

(The median citation count of Asian Pacific Journal of Tropical Biomedicine is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Ligustroside derived from Ligustrum japonicum inhibits melanogenesis via blocking the MAPK and PKA/CREB signaling pathways	40
Semen podocarpi extract enhances radiosensitivity in nasopharyngeal carcinoma cells via Raf/MEK/ERK signaling pathway	28
Anti-metastatic potential of OR3 pigment from Streptomyces coelicolor JUACT03 on MDA-MB-231 breast cancer in vitro and in vivo	20
Antioxidative, cytotoxic, and anti-metastatic potentials of Laurencia obtusa and Ulva lactuca seaweeds	15
Melatonin alleviates oxidative stress, inflammation, apoptosis, and DNA damage in acrylamide–induced nephrotoxicity in rats	12
Ethanol extract of Chondracanthus tenellus (Harvey) Hommersand attenuates lipopolysaccharide-induced inflammatory and oxidative response by blocking the NF-κB, MAPKs, and PI3K/Akt signaling pathways	12
Erianin inhibits oral cancer cell growth, migration, and invasion via the Nrf2/HO-1/ GPX4 pathway	11
Scopoletin	11
Antiviral efficacy of Andrographis paniculata and andrographolides: A narrative review	11
Syringic acid induces cancer cell death in the presence of Cu (II) ions via pro-oxidant activity	11
Grifola frondosa polysaccharides alleviate Alzheimer's disease in rats	11
Erratum to " Celastrus paniculatus oil ameliorates synaptic plasticity in a rat model of attention deficit hyperactivity disorder"	9
Chrysanthemum indicum ethanol extract attenuates hepatic stellate cell activation in vitro and thioacetamide-induced hepatofibrosis in rats	9
Total flavonoids from Saussurea involucrata attenuate inflammation in lipopolysaccharide-stimulated RAW264.7 macrophages via modulating p65, c-Jun, and IRF3 signaling pathways	9
Lentinula edodes extract inhibits matrix metalloproteinase expression and increases type I procollagen expression via the p38 MAPK/c-Fos signaling pathway in ultraviolet A and B-irradiated HaCaT kerat	8
Extract of Codiaeum luzonicum Merr. overcomes multidrug resistance in human colon cancer cells by modulating P-glycoprotein	8
Valencene-rich fraction from Vetiveria zizanioides exerts immunostimulatory effects in vitro and in mice	8
Dieckol isolated from Eisenia bicyclis extract suppresses RANKL-induced osteoclastogenesis in murine RAW 264.7 cells	8
Gum resin extract of Boswellia serrata attenuates lipopolysaccharide-induced inflammation and oxidative damage in hepatic and renal tissues of rats	8
Hydrangea serrata extract exerts tumor inhibitory activity against hepatocellular carcinoma HepG2 cells via inducing p27/CDK2-mediated cell cycle arrest and apoptosis	8
Anti-inflammatory effects of Solanum procumbens on a low dose complete Freund's adjuvant-induced arthritis rat model	8
Phytochemicals, pharmacological and ethnomedicinal studies of Artocarpus	7
Effect of hydroalcoholic leaf extract of Cassia fistula L. on type II collagen-induced arthritis in rats	7
Anti-arthritic effect of Distemonanthus benthamianus extracts against rheumatoid arthritis in rats	7
Anticancer activity of Δ9-tetrahydrocannabinol and cannabinol in vitro and in human lung cancer xenograft	7

Epigallocatechin-3-gallate exerts antihypertensive effects and improves endothelial function in spontaneously hypertensive rats	7
Catalpa bignonioides extract improves exercise performance through regulation of growth and metabolism in skeletal muscles	7
New trends in pharmacological treatment of acute kidney injury	7
In-silico and in-vitro evaluation of docetaxel and berberine as potential p53 modulating apoptotic inducers in oral squamous cell carcinoma	6
Metabolomics in drug discovery: Restoring antibiotic pipeline	6
Therapeutic potential of Calotropis gigantea extract against invasive pulmonary aspergillosis	6
Coleus forskohlii shows anti-psoriatic activity in imiquimod-induced psoriasis rats	6
Anthrahydroquinone-2,6-disulfonate alleviates paraquat-induced kidney injury via the apelin-APJ pathway in rats	6
Icariin plus curcumol enhances autophagy through the mTOR pathway and promotes cathepsin B-mediated pyroptosis of prostate cancer cells	6
Phytosomal curcumin alleviates collagen-induced arthritis by downregulating Th17 and upregulating Treg cell responses in rats	6
Acanthus leucostachyus leaf extracts promote excision wound healing in mice	6
Natural sources, biosynthesis, biological functions, and molecular mechanisms of shikimic acid and its derivatives	6
Ellagic acid inhibits gastric cancer cells by modulating oxidative stress and inducing apoptosis	5
Zinc oxide nanoparticles accelerate the healing of methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds in rabbits	5
Arecoline, a main alkaloid in Areca catechu, induces biological changes in human papillomavirus 16-positive cervical cancer cells via upregulation of viral oncogenes and cellular transcriptional facto	5
Anti-viral and anti-inflammatory effects of kaempferol and quercetin and COVID-2019	5
Colon cancer and their targeting approaches through nanocarriers	5
Coumarin and eugenol ameliorate LPS-induced inflammation in RAW 264.7 cells via modulating the NLRP3 inflammasome pathway	5
Nanoemulsion containing a synergistic combination of curcumin and quercetin for nose-to-brain delivery	5
Senna petersiana inhibits key digestive enzymes and modulates dysfunctional enzyme activities in oxidative pancreatic injury	5
Analgesic-like activity of perillyl acetate	5
Gedunin attenuates streptozotocin-induced diabetic hepatopathy in rats	5
Naringenin suppresses NLRP3 inflammasome activation via the mRNA-208a signaling pathway in isoproterenol-induced myocardial infarction	5
Anti-angiogenesis and anti-inflammatory effects of Moringa oleifera leaf extract in the early stages of streptozotocin-induced diabetic nephropathy in rats	5
Plant-derived natural compounds in the treatment of arsenic-induced toxicity	4
Levisticum officinale extract protects against CCl4-induced hepatotoxicity through anti-inflammatory, anti-fibrotic, and antioxidant properties in rats	4
Hepato- and reno-protective effects of thymoquinone, crocin, and carvacrol	4
Inhibition mechanisms of secretome proteins from Paenibacillus polymyxa Kp10 and Lactococcus lactis Gh1 against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus	4
Molluscicidal effect of green synthesized silver nanoparticles using Azadirachta indica on Biomphalaria alexandrina snails and Schistosoma mansoni cercariae	4
Morin attenuates L-arginine induced acute pancreatitis in rats by downregulating myeloperoxidase and lipid peroxidation	4
Biochanin-A attenuates high-fat diet and streptozotocin-induced hyperlipidemia and oxidative stress in rats by improving antioxidant status and lipid metabolic markers	4
Antibacterial and anti-parasitic activities of Terfezia claveryi methanolic extract against some common pathogenic agents of infectious diarrhea	4
Immunomodulatory activity of polycaprolactone nanoparticles with calcium phosphate salts against Leishmania infantum infection	4
Flavone improves liver damage in nicotine-exposed rats via the Nrf2/HO-1 pathway	4
Mechanisms of medicinal plants in the treatment of diabetic wound	4
Anticancer drug screening of natural products	3
Origanum vulgare L. leaf extract alleviates finasteride-induced oxidative stress in mouse liver and kidney	3
Green synthesis, characterization, acaricidal, larvacidal, and repellent activities of copper nanoparticles of Astragalus sinicus against Hyalomma anatolicum	3
Non-alcoholic fatty liver disease	3
Isoimperatorin alleviates acetic acid–induced colitis in rats	3
Cytotoxic effects of Thai noni juice product ethanolic extracts against cholangiocarcinoma cell lines	3
Pyronaridine combined with diminazene aceturate inhibits Babesia in vitro and in vivo	3
Modulatory effect of D-pinitol on bleomycin-induced pulmonary fibrosis in rats	3
Hydroxysafflor yellow A protects against thioacetamide-induced liver fibrosis in rats via suppressing proinflammatory/fibrogenic mediators and promoting hepatic stellate cell senescence and apoptosis	3
Synergistic effect of flavonoids combined with antivenom on neutralisation of Naja naja venom	3
Salidroside attenuates oxygen and glucose deprivation-induced neuronal injury by inhibiting ferroptosis	3
Anti-tumor activity of rice bran hydrolysates on migration, invasion and angiogenesis	3
Betulin protects against isoproterenol-induced myocardial injury by inhibiting NF-κB signaling and attenuating cardiac inflammation and oxidative stress in rats	3
Methanolic extract of Ephedra alata inhibits breast cancer cells in vitro and in vivo	3
Therapeutic potential of Zataria multiflora: A narrative review of current evidence	3

Anti-inflammatory potential of black cumin seed oil and its nanoemulsion formulation against lipopolysaccharide-induced liver injury in mice	2
Antioxidant, antimicrobial, and anticancer effects of Achillea filipendulina L. against colon cancer	2
Oleuropein alleviates sepsis-induced acute lung injury via the AMPK/Nrf-2/HO-1 signaling	2
Natural compounds as potential inhibitors of SARS-CoV-2 main protease	2
Rosa moschata ameliorates haloperidol-induced Parkinson's disease via reduction of neurodegeneration and oxidative stress	2
Inhibitory effect of Cyrtomium falcatum on melanogenesis in α-MSH-stimulated B16F10 murine melanoma cells	2
Hexadecanoic acid-enriched extract of Halymenia durvillei induces apoptotic and autophagic death of human triple-negative breast cancer cells by upregulating ER stress	2
Characterization of the infectivity of an Indonesian Zika virus strain in mammalian cell lines	2
Human Wharton's jelly mesenchymal stem cells inhibit cytokine storm in acute respiratory distress syndrome in a rat model	2
Ginseng ameliorates pulmonary toxicity induced by silicon dioxide nanoparticles in rats	2
Bitter gourd extract improves glucose homeostasis and lipid profile via enhancing insulin signaling in the liver and skeletal muscles of diabetic rats	2
Dehydroabietic acid chemosensitizes drug-resistant acute lymphoblastic leukemia cells by downregulating survivin expression	2
Trigonelline exerts its neuroprotective effects in experimental spinal cord injury through modulation of inflammation, apoptosis, and neurotrophic factors	2
L-carvone attenuates myocardial injury and dyslipidemia in rats with isoproterenolinduced cardiac hypertrophy	2
β-Islet cell regeneration potential of Mirabilis jalapa in hyperglycemic rats	2
Anti-inflammatory and anti-cancer potential of pterostilbene: A review	2
Potential of polyphenols in curbing quorum sensing and biofilm formation in Gram-negative pathogens	2
Molluscicidal activities of green-synthesized Alstonia congensis silver nanoparticles	2
Characterization and antimicrobial, antioxidant, and anti-proliferative activities of green synthesized magnesium oxide nanoparticles with shoot extracts of Plicosepalus curviflorus	2
Anti-tumor effects and cellular mechanisms of Pistacia atlantica methanolic extract against Ehrlich solid tumor in mice	2
Cardioprotective effect of bioassay–guided fractions of Cleome viscosa methanolic extract in streptozotocin–induced diabetic rats	2
Phytochemical profiling and anticancer potential of Cymbopogon citratus extract	2
Sericin alleviates pentylenetetrazole kindling epilepsy and associated comorbidities via modulation of GABA-T enzyme and mitochondrial activity	2
Capsosiphon fulvescens suppresses LPS-stimulated inflammatory responses by suppressing TLR4/NF-κB activation in RAW264.7 murine macrophages	2
Macrophage-secreted exosomes inhibit breast cancer cell migration via the miR- 101-3p/DLG5 axis	2
Mpox and related poxviruses: A literature review of evolution, pathophysiology, and clinical manifestations	2
Th17/Treg balance and macrophage polarization ratio in lower extremity arteriosclerosis obliterans	2
Gracilaria fisheri oligosaccharides ameliorate inflammation and colonic epithelial barrier dysfunction in mice with acetic acid-induced colitis	2
Midkine ameliorates LPS-induced apoptosis of airway smooth muscle cells via the Notch2 pathway	1
Biological functions and diagnostic implications of microRNAs in Mycobacterium tuberculosis infection	1
Erratum to "Boeravinone B ameliorates allergic nasal inflammation by modulating the GATA-3/T-bet signaling pathway in a mouse model of allergic rhinitis"	1
Cardioprotective effects of total and anthocyanin-rich extracts of Opuntia ficus-indica fruit on epinephrine-induced cardiac injury in rats	1
Voacanga grandifolia (Miq.) Rolfe protects against alcohol-induced liver toxicity in rats	1
Asiaticoside ameliorates type 2 diabetes mellitus in rats by modulating carbohydrate metabolism and regulating insulin signaling	1
Kaempferol and its derivatives: Biological activities and therapeutic potential	1
Interleukin-33 exerts pleiotropic immunoregulatory effects in response to Plasmodium berghei ANKA (PbA) infection in mice	1
Cannabinoid CB2receptors and spinal microglia are implicated in tingenone-mediated antinociception in mice	1
Immune response to inactivated bacterial vector carrying the recombinant K39 antigen of Leishmania infantum in mice	1
G9a-targeted chaetocin induces pyroptosis of gastric cancer cells	1
Antimicrobial, antibiofilm, angiogenesis, anti-inflammatory, and wound healing activities of zinc nanoparticles green synthesized using Ferula macrecolea extract	1
Honokiol attenuates oxidative stress-induced cytotoxicity in human keratinocytes via activating AMPK signaling	1
Persicaria lanigera (Polygonaceae) leaf extract exhibits antiulcerogenic and antiproliferative activities against acetic acid-induced ulcerative colitis and cotton pellet-induced granuloma tissue in r	1
Hypoglycaemic, anti-hyperlipidemic, and anti-inflammatory activities of Asparagus africanus (Asparaceae) extract on high-fat diet/streptozotocin-induced diabetes in Wistar rats	1
Anti-obesity effect and UHPLC-QTOF-MS/MS based metabolite profiling of Solanum nigrum leaf extract	1
Phellinus igniarius ameliorates renal aging in a rat model of focal and segmental glomerulosclerosis	1
Schisandrae Fructus oil-induced elevation in serum triglyceride and lipoprotein concentrations associated with physiologic hepatomegaly in mice	1
Rhamnus crenata leaf extracts exhibit anti-inflammatory activity via modulating the Nrf2/HO-1 and NF-κB/MAPK signaling pathways	1
Combinatorial effect of diclofenac with piperine and D-limonene on inducing apoptosis and cell cycle arrest of breast cancer cells	1
RPRD1B/CREPT facilitates the progression of diffuse large B-cell lymphoma by inhibiting apoptosis through the NF-κB signaling pathway	1
Caffeic acid and protocatechuic acid modulate Nrf2 and inhibit Ehrlich ascites carcinomas in mice	1
Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in rats	1
Methyl gallate isolated from Mangifera pajang kernel induces proliferation inhibition and apoptosis in MCF-7 breast cancer cells via oxidative stress	1
Persea americana attenuates inflammatory response associated with hyperlipidemia in ovariectomized and irradiated rats by regulating MMP-3/TIMP-1 levels	1
Glinus lotoides ethanolic extract alleviates LPS-induced anxiety and depression-like behavior by modulating antioxidant and inflammatory biomarkers in rats	1
Prodigiosin from Serratia	1
Anti-leishmanial, immunomodulatory and anti-oxidative activity of quercetin against cutaneous leishmaniasis caused by Leishmania major	1
An in vitro and in silico study of anti-dermatophytic activity of gossypol from fruits of Thespesia populnea (L.) Sol. ex Correa	1
Potential immunomodulatory role of sesamin in combating immune dysregulation associated with COVID-19	1
In vitro antimicrobial and synergistic effect of essential oil from the red macroalgae Centroceras clavulatum (C. Agardh) Montagne with conventional antibiotics	1
Luteolin attenuates diabetic nephropathy via inhibition of metalloenzymes in rats	1
Apigenin ameliorates diabetic neuropathy in rats by modulating the TLR4/MyD88 signaling pathway	1
Biopeptides of Pyropia yezoensis and their potential health benefits	1
Ardisia gigantifolia ethanolic extract inhibits cell proliferation and targets cancer stem cells in gastric cancer	1
Analgesic and anti-inflammatory activity of Cotinus coggygria Scop. extracts in vivo	1
Phytocompounds and lipid-based drug delivery system for neurodegenerative diseases	1
Role of flaxseed (Linum usitatissimum L.) in disease prevention and treatment	1
Harpephyllum caffrum stimulates glucose uptake, abates redox imbalance and modulates purinergic and glucogenic enzyme activities in oxidative hepatic injury	1
Aqueous extract of Protaetia brevitarsis larvae increases mTOR-mediated growth rate in zebrafish larvae	1
Astragalus adscendens extract shows antidiabetic effects through controlling oxidative stress, inflammation and apoptosis in streptozotocin-induced diabetic rats	1
T6SS-5 and the cGAS-STING pathway in Burkholderia pseudomallei infection and immunity	1
Icariin ameliorates viral myocarditis by inhibiting TLR4-mediated ferroptosis	1
Ethyl acetate extract of Smilax glabra Roxb roots and its major active compound astilbin promote osteoblastogenesis in vitro by upregulating bone cell differentiation- associated genes	1
Aqueous extract of freeze-dried Protaetia brevitarsis larvae promotes osteogenesis by activating β-catenin signaling	1
Humulus japonicus extract alleviates oxidative stress and apoptosis in 6-hydroxydopamine-induced PC12 cells	1
ClpB chaperone as a promising target for antimicrobial therapy: A narrative review	1