OOIR: Observatory of International Research

Papers

(The H4-Index of Biomolecules is 75. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
The Functional Differences between the GroEL Chaperonin of Escherichia coli and the HtpB Chaperonin of Legionella pneumophila Can Be Mapped to Specific Amino Acid Residues	525
Postbiotics of Naturally Fermented Synbiotic Mixture of Rice Water Aids in Promoting Colonocyte Health	375
Probing the Dual Role of Ca2+ in the Allochromatium tepidum LH1–RC Complex by Constructing and Analyzing Ca2+-Bound and Ca2+-Free LH1 Complexes	284
Deletion of Murine APP Aggravates Tau and Amyloid Pathologies in the 5xFADXTg30 Alzheimer’s Disease Model	263
Catestatin and Advanced Glycation End-Products: Potential Indicators of Cardiovascular Risk in Hashimoto’s Thyroiditis	255
Sex Differences in the Associations Among Early Life Adversity, Inflammation, and Cognition	223
Paxillin and Kindlin: Research Progress and Biological Functions	223
Tryptophan Kynurenine Pathway-Based Imaging Agents for Brain Disorders and Oncology—From Bench to Bedside	219
From Waste to Innovation: A Circular Economy Approach for Tissue Engineering by Transforming Human Bone Waste into Novel Collagen Membranes	214
Structure-Based Approaches for Protein–Protein Interaction Prediction Using Machine Learning and Deep Learning	213
M6A Demethylase ALKBH5 in Human Diseases: From Structure to Mechanisms	206
Mitochondrial Transplantation in Animal Models of Psychiatric Disorders: A Novel Approach to Psychiatric Treatment	175
CXCL12 as a Potential Hub Gene for N-Acetylcysteine Treatment of T1DM Liver Disease	172
Perception and Longevity Control in Invertebrate Model Organisms—A Mini-Review of Recent Advances	169
Research Progress on the Influence of Novel Targeted Drugs for Osteoporosis on Glucose Metabolism	165
Mechanical Forces, Nucleus, Chromosomes, and Chromatin	164
Pleiotropic Effects of Grm7/GRM7 in Shaping Neurodevelopmental Pathways and the Neural Substrate of Complex Behaviors and Disorders	158
Multifaceted Therapeutic Potential of Plant-Derived Exosomes: Immunomodulation, Anticancer, Anti-Aging, Anti-Melanogenesis, Detoxification, and Drug Delivery	153
Revolutionizing mRNA Vaccines Through Innovative Formulation and Delivery Strategies	152
A Review on the Etiologies of the Development of Atrial Fibrillation After Cardiac Surgery	146
The Human Thyroid-Derived CI-huThyrEC Cell Line Expresses the Thyrotropin (TSH) Receptor and Thyroglobulin but Lacks Other Essential Characteristics of Thyroid Follicular Cells	144
RNA-Binding Protein Signature in Proliferative Cardiomyocytes: A Cross-Species Meta-Analysis from Mouse, Pig, and Human Transcriptomic Profiling Data	143
Long-Term Consequences of Placental Vascular Pathology on the Maternal and Offspring Cardiovascular Systems	140
Tenascin-C: A Key Regulator in Angiogenesis during Wound Healing	138
Primary Amoebic Meningoencephalitis by Naegleria fowleri: Pathogenesis and Treatments	130

Morphological and Biophysical Study of S100A9 Protein Fibrils by Atomic Force Microscopy Imaging and Nanomechanical Analysis	130
Peptidomimetics and Their Applications for Opioid Peptide Drug Discovery	129
A Promising Candidate in Tendon Healing Events—PDGF-BB	129
Advances in Immunomodulatory Mesoporous Silica Nanoparticles for Inflammatory and Cancer Therapies	129
Metal-Based Nanoparticles in Food Packaging and Coating Technologies: A Review	128
Modulation of the Antioxidant Defense System by Exogenous l-Glutamic Acid Application Enhances Salt Tolerance in Lentil (Lens culinaris Medik.)	127
Combined Anti-Adipogenic Effects of Hispidulin and p-Synephrine on 3T3-L1 Adipocytes	126
Stability of Blueberry Extracellular Vesicles and Their Gene Regulation Effects in Intestinal Caco-2 Cells	126
Fungal Endophytes: Microfactories of Novel Bioactive Compounds with Therapeutic Interventions; A Comprehensive Review on the Biotechnological Developments in the Field of Fungal Endophytic Biology ove	124
A Conserved Hydrophobic Moiety and Helix–Helix Interactions Drive the Self-Assembly of the Incretin Analog Exendin-4	124
Pro-Inflammatory and Cytotoxic Effects of Polystyrene Microplastics on Human and Murine Intestinal Cell Lines	124
(Pentamethylcyclopentadienyl)chloridoiridium(III) Complex Bearing Bidentate Ph2PCH2CH2SPh-κP,κS Ligand	123
The Impact of Pancreatic Exocrine Diseases on the β-Cell and Glucose Metabolism—A Review with Currently Available Evidence	122
DEER Analysis of GPCR Conformational Heterogeneity	122
Phosphatidylserine: A Novel Target for Ischemic Stroke Treatment	122
Melanogenesis and the Targeted Therapy of Melanoma	120
A Comparison of Cell-Cell Interaction Prediction Tools Based on scRNA-seq Data	119
Metformin Induces Resistance of Cancer Cells to the Proteasome Inhibitor Bortezomib	117
Quality Evaluation of Ophiopogon japonicus from Two Authentic Geographical Origins in China Based on Physicochemical and Pharmacological Properties of Their Polysaccharides	111
Screening Plasma Exosomal RNAs as Diagnostic Markers for Cervical Cancer: An Analysis of Patients Who Underwent Primary Chemoradiotherapy	108
The Mechanism of CD8+ T Cells for Reducing Myofibroblasts Accumulation during Renal Fibrosis	105
Metformin Prevents NDEA-Induced Memory Impairments Associated with Attenuating Beta-Amyloid, Tumor Necrosis Factor-Alpha, and Interleukin-6 Levels in the Hippocampus of Rats	103
Neuroimmune Crossroads: The Interplay of the Enteric Nervous System and Intestinal Macrophages in Gut Homeostasis and Disease	100
An Update on S100A16 in Human Cancer	99
Molecular Simulation-Based Investigation of Highly Potent Natural Products to Abrogate Formation of the nsp10–nsp16 Complex of SARS-CoV-2	98
Molecular Mechanisms and the Significance of Synonymous Mutations	97
Insect Models in Nutrition Research	96
Plant-Derived Bioactive Compounds and Potential Health Benefits: Involvement of the Gut Microbiota and Its Metabolic Activity	96
Hypoxia Alters the Proteome Profile and Enhances the Angiogenic Potential of Dental Pulp Stem Cell-Derived Exosomes	96
COVID-19 and Parkinsonism: A Critical Appraisal	95
Current Prognostic Biomarkers for Abdominal Aortic Aneurysm: A Comprehensive Scoping Review of the Literature	95
Protective Role of Physical Activity and Antioxidant Systems During Spermatogenesis	94
Macrophages in Skin Wounds: Functions and Therapeutic Potential	91
RETRACTED: Maifata et al. Role of Serum and Urine Biomarkers (PLA2R and THSD7A) in Diagnosis, Monitoring and Prognostication of Primary Membranous Glomerulonephritis. Biomolecules 2020, 10, 319	89
Feasibility of Ex Vivo Ligandomics	89
Inositol Phosphates and Synthesizing Enzymes: Implications in Neurodegenerative Disorders	88
Autophagy and Cancer: Insights into Molecular Mechanisms and Therapeutic Approaches for Chronic Myeloid Leukemia	88
Improving Identification of Drug-Target Binding Sites Based on Structures of Targets Using Residual Graph Transformer Network	87
Chronic Coronary Artery Disease: Wall Disease vs. Lumenopathy	86
Protein Arginine Methyltransferase 1: A Multi-Purpose Player in the Development of Cancer and Metabolic Disease	85
Determining Ligand Binding and Specificity Within the β2-Integrin Family with a Novel Assay Platform	84
Rosmarinic Acid and Related Dietary Supplements: Potential Applications in the Prevention and Treatment of Cancer	83
Chemical and Transcriptomic Analyses of Leaf Cuticular Wax Metabolism in Ammopiptanthus mongolicus under Osmotic Stress	82
Micro-Osteoperforations Accelerate Tooth Movement without Exacerbating the Progression of Root Resorption in Rats	82
Atypical Substrates of the Organic Cation Transporter 1	81
Modeling Autism Spectrum Disorders with Induced Pluripotent Stem Cell-Derived Brain Organoids	79
The Resistome of ESKAPEE Pathogens in Untreated and Treated Wastewater: A Polish Case Study	79
Group I Metabotropic Glutamate Receptors Modulate Motility and Enteric Neural Activity in the Mouse Colon	78
Aldosterone: Essential for Life but Damaging to the Vascular Endothelium	77
A Novel Antiviral Protein Derived from Oenanthe javanica: Type I Interferon-Dependent Antiviral Signaling and Its Pharmacological Potential	77

Exercise, Neuroprotective Exerkines, and Parkinson’s Disease: A Narrative Review	75
AGR2: The Covert Driver and New Dawn of Hepatobiliary and Pancreatic Cancer Treatment	75
Mesenchymal Stem Cell-Derived Extracellular Vesicles: An Emerging Diagnostic and Therapeutic Biomolecules for Neurodegenerative Disabilities	75