OOIR: Observatory of International Research

Papers

(The median citation count of Life Sciences in Space Research is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
A review of astronaut mental health in manned missions: Potential interventions for cognitive and mental health challenges	38
The effects of microgravity on the digestive system and the new insights it brings to the life sciences	33
Applicability of composite materials for space radiation shielding of spacecraft	30
Biology and crop production in Space environments: Challenges and opportunities	29
Plant biology for space exploration – Building on the past, preparing for the future	24
Review of research into bioregenerative life support system(s) which can support humans living in space	24
Galactic cosmic ray simulation at the NASA space radiation laboratory – Progress, challenges and recommendations on mixed-field effects	21
Improving astronaut cancer risk assessment from space radiation with an ensemble model framework	21
Plant responses to real and simulated microgravity	21
Growth and photosynthetic responses of Chinese cabbage (Brassica rapa L. cv. Tokyo Bekana) to continuously elevated carbon dioxide in a simulated Space Station “Veggie” crop-production environment	20
Updated deterministic radiation transport for future deep space missions	20
Negative impact of disuse and unloading on tendon enthesis structure and function	20
Reversing radiation-induced immunosuppression using a new therapeutic modality	19
A proposed change to astronaut exposures limits is a giant leap backwards for radiation protection	19
Thick shielding against galactic cosmic radiation: A Monte Carlo study with focus on the role of secondary neutrons	19
Recent developments in space food for exploration missions: A review	18
Lignocellulose degradation, biogas production and characteristics of the microbial community in solid-state anaerobic digestion of wheat straw waste	18
A non-invasive approach to monitor anemia during long-duration spaceflight with retinal fundus images and deep learning	17
Small tissue chips with big opportunities for space medicine	16
The COSPAR Planetary Protection Policy for robotic missions to Mars: A review of current scientific knowledge and future perspectives	16
Gastrodia elata blume ameliorates circadian rhythm disorder-induced mice memory impairment	15
Transfer learning as an AI-based solution to address limited datasets in space medicine	14
Heavy ion space radiation triggers ongoing DNA base damage by downregulating DNA repair pathways	14
The neurology of space flight; How does space flight effect the human nervous system?	14
Long term food stability for extended space missions: a review	14

Identification of interstellar amino acetonitrile in the hot molecular core G10.47＋0.03: Possible glycine survey candidate for the future	14
Extended reality quantification of pupil reactivity as a non-invasive assessment for the pathogenesis of spaceflight associated neuro-ocular syndrome: A technology validation study for astronaut healt	14
Simultaneous exposure to chronic irradiation and simulated microgravity differentially alters immune cell phenotype in mouse thymus and spleen	13
Benchmarking risk predictions and uncertainties in the NSCR model of GCR cancer risks with revised low let risk coefficients	13
Private Spaceflight: A New Landscape for Dealing with Medical Risk	13
The Need for Biological Countermeasures to Mitigate the Risk of Space Radiation-Induced Carcinogenesis, Cardiovascular Disease, and Central Nervous System Deficiencies	13
Dynamic visual acuity as a biometric for astronaut performance and safety	12
Survival of desert algae Chlorella exposed to Mars-like near space environment	11
Application of functional microbial agent in aerobic composting of wheat straw for waste recycling	10
Advanced food packaging systems for space exploration missions	10
Impact of galactic cosmic ray simulation on nutritional content of foods	9
Limb position sense and sensorimotor performance under conditions of weightlessness	9
The lack of mass transfer in bone lacunar-canalicular system may be the decisive factor of osteoporosis under microgravity	9
Effects of dietary aspirin on high-LET radiation-induced prostaglandin E2 levels and gastrointestinal tumorigenesis in Apc mice	9
What can space radiation protection learn from radiation oncology?	9
Crew time and workload in the EDEN ISS greenhouse in Antarctica	9
RRx-001 and the “Right stuff”: Protection and treatment in outer space	9
A novel device to study altered gravity and light interactions in seedling tropisms	9
Spaceflight validation of technology for point-of-care monitoring of peripheral blood WBC and differential in astronauts during space missions	9
Population analysis of space travelers	9
Characterization of exosome release and extracellular vesicle-associated miRNAs for human bronchial epithelial cells irradiated with high charge and energy ions	8
Breaking the limit: Biological countermeasures for space radiation exposure to enable long-duration spaceflight	8
Space radiation does not alter amyloid or tau pathology in the 3xTg mouse model of Alzheimer's disease	8
Targeting hippocampal neurogenesis to protect astronauts’ cognition and mood from decline due to space radiation effects	8
Aquatic invertebrate protein sources for long-duration space travel	8
Crew time in a space greenhouse using data from analog missions and Veggie	8
Investigating alterations in the cellular envelope of Staphylococcus aureus in simulated microgravity using a random positioning machine	8
Suppression of endoplasmic reticulum stress prevents disuse muscle atrophy in a mouse model of microgravity	7
Comparison of two controlled-release fertilizer formulations for cut-and-come-again harvest yield and mineral content of Lactuca sativa L. cv. Outredgeous grown under International Space Station envir	7
Comparative study of methods for detecting extraterrestrial life in exploration mission of Mars and the solar system	7
Hybrid methods of radiation shielding against deep-space radiation	7
Effects of partial- or whole-body exposures to 56Fe particles on brain function and cognitive performance in rats	7
A new type of ground-based simulator of radiation field inside a spacecraft in deep space	7
Extracellular vesicles-derived microRNAs expression as biomarkers for neurological radiation injury: Risk assessment for space exploration	7
Cancer incidence risks above and below 1 Gy for radiation protection in space	7
Assessment of Spaceflight Medical Conditions’ and Treatments’ Potential Impacts on Behavioral Health and Performance	7
Looking on the horizon; potential and unique approaches to developing radiation countermeasures for deep space travel	7
Microgravity alters the expressions of DNA repair genes and their regulatory miRNAs in space-flown Caenorhabditis elegans	7
Baoyuan jieyu formula ameliorates depression-like behaviour in rats induced by simulated long-term spaceflight composite stress through regulating MAPK and BDNF pathways	6
Operation overview of a biological waste treatment system during the 4-crew 180-day integrated experiment in the controlled ecological life support system (CELSS)	6
Subsequent inclusion/exclusion criteria to select the best species for an experiment performed on the ISS in a refurbished hardware	6
Simulated weightlessness induces cognitive changes in rats illustrated by performance in operant conditioning tasks	6
New evidence and insight for abnormalities in early embryonic development after short-term spaceflight onboard the Chinese SJ-10 satellite	5
Development of a NASA roadmap for planetary protection to prepare for the first human missions to Mars	5
Calculation of dose distribution in a realistic brain structure and the indication of space radiation influence on human brains	5
Mouse genomic associations with in vitro sensitivity to simulated space radiation	5
Real versus simulated galactic cosmic radiation for investigating cancer risk in the hematopoietic system - are we comparing apples to apples?	5
Effects of low-dose oxygen ions on cardiac function and structure in female C57BL/6J mice	5
Observation of the radiation environment and solar energetic particle events in Mars orbit in May 2018- June 2022	5
Design and establishment of a large-scale controlled ecological life-support system integrated experimental platform	5

Proteomic analysis of the effects of simulated microgravity in human gastric mucosal cells	5
3D printing for space food applications: Advancements, challenges, and prospects	5
Comparison between PHITS and GEANT4 Simulations of the Heavy Ion Beams at the BEVALAC at LBNL and the Booster Accelerator at BNL	5
Nonhuman primate models in the study of spaceflight stressors: Past contributions and future directions	5
“Spaceflight-to-Eye Clinic”: Terrestrial advances in ophthalmic healthcare delivery from space-based innovations	5
Long-term pharmacological torpor of rats with feedback-controlled drug administration	5
Phenotypic and transcriptional changes in Escherichia coli K12 in response to simulated microgravity on the EagleStat, a new 2D microgravity analog for bacterial studies.	5
The COSPAR planetary protection requirements for space missions to Venus	5
Effects of stepwise changes in dissolved carbon dioxide concentrations on metabolic activity in Chlorella for spaceflight applications	5
Recycling nutrients from organic waste for growing higher plants in the Micro Ecological Life Support System Alternative (MELiSSA) loop during long-term space missions	4
Effects of short-term hypergravity on hematopoiesis and vasculogenesis in embryonic zebrafish	4
Countermeasure development against space radiation-induced gastrointestinal carcinogenesis: Current and future perspectives	4
Study on primary physicochemical characteristics and nutrient adsorption of four plant cultivation substrates	4
Inter-agency perspective: Translating advances in biomarker discovery and medical countermeasures development between terrestrial and space radiation environments	4
Inhibition of SIRT1 by miR-138-5p provides a mechanism for inhibiting osteoblast proliferation and promoting apoptosis under simulated microgravity	4
Advances in planetary sustainability	4
Observations of neutron radiation environment during Odyssey cruise to Mars	4
Medical countermeasures for the hematopoietic-subsyndrome of acute radiation syndrome in space	4
Modeling a lunar base mushroom farm	4
Angiotensin converting enzyme (ACE) inhibitors as radiation countermeasures for long-duration space flights	4
Effect of reduced atmospheric pressure on growth and quality of two lettuce cultivars	4
HERA: A Timepix-based radiation detection system for Exploration-class space missions	4
Galactic cosmic ray environment predictions for the NASA BioSentinel mission	4
Medial prefrontal cortex and hippocampus in mice differently affected by simulate microgravity and social isolation associated with the alternation of emotional and cognitive functions	4
Comparison of the particle flux measured by Liulin-MO dosimeter in ExoMars TGO science orbit with those calculated by models	4
Effects of the geomagnetic field time–varying components compensation as evidenced by heart rate variability of healthy males.	4
Carbonate precipitation and nitrogen fixation in AMG (Artificial Martian Ground) by cyanobacteria	4
Optimized crop growth area composition for long duration spaceflight	4
Clinical Trial in a Dish for Space Radiation Countermeasure Discovery	4
The neutron dose equivalent rate measurements by R3DR/R2 sp ectrometers on the international space station	4
Microbial diversity formation and maintenance due to temporal niche differentiation caused by low-dose ionizing radiation in oligotrophic environments	4
Mimic microgravity effect on muscle transcriptome under ionizing radiation	4
Accelerating space radiation countermeasure development through drug repurposing	4
Microglia: Rheostats of space radiation effects in the CNS microenvironment	4
High throughput screen of small molecules as potential countermeasures to galactic cosmic radiation induced cellular dysfunction	3
Design of a modular controlled unit for the study of bioprocesses: Towards solutions for Bioregenerative Life Support Systems in space	3
Mitigation of late cardiovascular effects of oxygen ion radiation by γ-tocotrienol in a mouse model	3
Bioregenerative life support space diet and nutrition requirements: still seeking accord	3
Comprehensive analyses of plant hormones in etiolated pea and maize seedlings grown under microgravity conditions in space: Relevance to the International Space Station experiment “Auxin Transport”	3
Effects of simulated microgravity and vibration on osteoblast and osteoclast activity in cultured zebrafish scales	3
Countermeasure efficacy of apigenin for silicon-ion-induced early damage in blood and bone marrow of exposed C57BL/6J mice	3
Effects of combined exposure to modeled radiation and gravitation factors of the interplanetary flight: Monkeys' cognitive functions and the content of monoamines and their metabolites; cytogenetic ch	3
Biomechanics of healthy subjects during exercise on a simulated vibration isolation and stabilization system	3
Results from the Radiation Assessment Detector on the International Space Station: Part 1, the Charged Particle Detector	3
Armed Forces Radiobiology Research Institute/Uniformed Services University of the Health Sciences perspective on space radiation countermeasure discovery	3
Simulated microgravity accelerates aging in Saccharomyces cerevisiae	3
Breathing life into Mars: Terraforming and the pivotal role of algae in atmospheric genesis	3
Simulated galactic cosmic radiation (GCR)-induced expression of Spp1 coincide with mammary ductal cell proliferation and preneoplastic changes in Apc mouse	3
High-throughput screening strategies for space-based radiation countermeasure discovery	3
Cardiovascular changes under the microgravity environment and the gut microbiome	3
Harnessing nucleic acid technologies for human health on earth and in space	3
Mechano-immunology in microgravity	3
Non-targeted effects and space radiation risks for astronauts on multiple International Space Station and lunar missions	2
Particle showers detected on ISS in Timepix pixel detectors	2
Relationship of collagen as the component of the extracellular matrix with the mechanisms of autonomic regulation of the cardiovascular system under simulated conditions of long-term isolation	2
Synthetic biological circuit tested in spaceflight	2
Active radiation measurements over one solar cycle with two DOSTEL instruments in the Columbus laboratory of the International Space Station	2
Hemerocallis citrina Baroni ameliorates chronic sleep deprivation-induced cognitive deficits and depressive-like behaviours in mice	2
The importance of time-resolved personal Dosimetry in space: The ISS Crew Active Dosimeter	2
The effects of microgravity on stem cells and the new insights it brings to tissue engineering and regenerative medicine	2
Contemporary review of dermatologic conditions in space flight and future implications for long-duration exploration missions	2
A method to predict space radiation biological effectiveness for non-cancer effects following intense Solar Particle Events	2
Imaging in spaceflight associated neuro-ocular syndrome (SANS): Current technology and future directions in modalities	2
Glycogen metabolism is required for optimal cyanobacterial growth in the rapid light-dark cycle of low-Earth orbit	2
Evolving radiological protection guidelines for exploration-class missions	2
Results from the Radiation Assessment Detector on the International Space Station, Part 2: The fast neutron detector	2
Results of long-term radiation environment monitoring by the Russian RMS system on board Zvezda module of the ISS	2
Compact portable sources of high-LET radiation: Validation and potential application for galactic cosmic radiation countermeasure discovery	2
Accumulation of high-energy phosphates blocks the expression of mitochondrial biogenesis markers and slow-type myosin in soleus muscle under 24 hours of rat hindlimb suspension	2
Radiation measurements in the International Space Station, Columbus module, in 2020–2022 with the LIDAL detector	2
Increase in steryl glycoside levels and stimulation of lipid raft formation in azuki bean epicotyls under hypergravity conditions	2
The MaMBA facility as a testbed for bioregenerative life support systems	2
Combined effect of simulated microgravity and low-dose ionizing radiation on structure and antibiotic resistance of a synthetic community model of bacteria isolated from spacecraft assembly room	2
Cancer and circulatory disease risks for the largest solar particle events in the space age	2