Life Sciences in Space Research

Article	Citations
Biofilm dynamics in space and their potential for sustainable space exploration – A comprehensive review	34
Anthocyanin can improve the survival of rice seeds from solar light outside the international space station	30
3D culture and cryopreservation/thawing strategy of human induced pluripotent stem cells for spaceflight experiments	28
Challenges and innovations in food and water availability for a sustainable Mars colonization	28
Organ dose equivalents of albedo protons and neutrons under exposure to large solar particle events during lunar human landing missions	22
IFC - Editorial Board	20
Results from the Radiation Assessment Detector on the International Space Station: Part 1, the Charged Particle Detector	18
Effect of countermeasure bodygear on cardiac-vascular-respiratory coupling during 6-degree head-down tilt: An earth-based microgravity study	18
A no-fault risk compensation approach for radiation risks incurred in space travel	17
The case for anterior segment optical coherence tomography (AS-OCT) for the international space station and future planetary spaceflight: Clinical relevance and technical implementation	17
From Antarctic regolith to lunar greenhouses: Mechanistic insights into Brassica rapa photosystem II dynamics for sustainable space agriculture	17
RadLab: An open science resource for radiation studies relevant to human spaceflight	17
Domestication of Radiation Sensitive Caenorhabditis Elegans Strains Suitable For Liquid Culture Systems In Long-Term Space Mission	17
Reorganization of the mouse oocyte' cytoskeleton after cultivation under simulated weightlessness	16
Comprehensive omics strategies for space agriculture development	16
IFC - Editorial Board	16
Residual radiation risk disparities across sex and race or ethnic groups for lifetime never-smokers on lunar missions	16
Analysis of suitable site candidates for Mars human habitat and life-support technologies based on in situ water resource utilization	15
IFC - Editorial Board	15
Radiation environment on TGO Mars orbit during solar particle events in January–October 2024. Corresponding solar eruptions and GOES proton fluxes data	15
Lignocellulose degradation, biogas production and characteristics of the microbial community in solid-state anaerobic digestion of wheat straw waste	15
Neuroprotective and neuromodulatory role of agmatine in mitigating simulated microgravity-induced cognitive and behavioral deficits in rats	13
Galactic cosmic ray environment predictions for the NASA BioSentinel Mission, part 2:Post-mission validation	13
Optimizing autonomous artificial intelligence diagnostics for neuro-ocular health in space missions	12
Disparity in the effect of partial gravity simulated using a new apparatus on different rat hindlimb muscles	12

Construction of microgravity biological knowledge graph and its applications in anti-osteoporosis drug prediction	12
Comparative study of methods for detecting extraterrestrial life in exploration mission of Mars and the solar system	12
Behavior of simple closed ecological systems; lower nutrient concentrations allow longer persistence of grazer populations	11
Infrared spectroscopy reveals ethylene glycol is an anti-crystallizer in water mixed astrochemical ices	11
Recent progresses on space life science research in China	10
The neurology of space flight; How does space flight effect the human nervous system?	10
High-throughput screening strategies for space-based radiation countermeasure discovery	10
Study on primary physicochemical characteristics and nutrient adsorption of four plant cultivation substrates	9
A method to predict space radiation biological effectiveness for non-cancer effects following intense Solar Particle Events	9
The COSPAR Planetary Protection Policy for robotic missions to Mars: A review of current scientific knowledge and future perspectives	9
Integrated spaceflight transcriptomic analyses and simulated space experiments reveal key molecular features and functional changes driven by space stressors in space-flown C. elegans	8
Tissue-specific dose equivalents of secondary mesons and leptons during galactic cosmic ray exposures for mars exploration	8
Impact of weightlessness on dynamic deformation and haemodynamic parameters of the heart	8
Involvement of KATANIN1, a microtubule-severing enzyme, in hypergravity-induced modification of growth anisotropy in Arabidopsis hypocotyls	8
Simulated microgravity altered the gene expression profiles and inhibited the proliferation of Kupffer cells in the early phase by downregulating LMO2 and EZH2	8
Pinoresinol diglucoside alleviates hindlimb unloading-induced bone loss in mice	8
Accumulation of high-energy phosphates blocks the expression of mitochondrial biogenesis markers and slow-type myosin in soleus muscle under 24 hours of rat hindlimb suspension	7
Angiotensin converting enzyme (ACE) inhibitors as radiation countermeasures for long-duration space flights	7
Results from the Radiation Assessment Detector on the International Space Station, Part 2: The fast neutron detector	7
Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading	7
Microbes and nutrient shift in a Closed Aquatic Ecosystem (CAES) during four weeks of operation	7
Effects of social isolation and galactic cosmic radiation on fine motor skills and behavioral performance	7
Transfer learning as an AI-based solution to address limited datasets in space medicine	7
IFC - Editorial Board	7
IFC - Editorial Board	6
Evolving radiological protection guidelines for exploration-class missions	6
Simulated space environmental factors of weightlessness, noise and low atmospheric pressure differentially affect the diurnal rhythm and the gut microbiome	6
Solid waste management and resource recovery during the 4-crew 180-day CELSS integrated experiment	6
Impact of gravitational forces on Red Blood Cell dynamics in biofluid suspension	6
Approaching ocular risks during spaceflight with 3D printing: Technical strategies to protect astronaut vision	6
Small tissue chips with big opportunities for space medicine	6
Parabolic flight as a research platform to investigate ophthalmic changes in microgravity	6
Reduced gravity effects on gait coordinative structures	6
Spaceflight validation of technology for point-of-care monitoring of peripheral blood WBC and differential in astronauts during space missions	6
IFC - Editorial Board	6
Medical countermeasures for the hematopoietic-subsyndrome of acute radiation syndrome in space	6
IFC - Editorial Board	5
Cardiovascular adaptations in microgravity conditions	5
Improving astronaut cancer risk assessment from space radiation with an ensemble model framework	5
Leveraging lower body negative pressure for enhanced outcomes in orthopedic arthroplasty—Insights from NASA’s bone health research	5
Relationship of collagen as the component of the extracellular matrix with the mechanisms of autonomic regulation of the cardiovascular system under simulated conditions of long-term isolation	5
IFC - Editorial Board	5
Effects of low-dose oxygen ions on cardiac function and structure in female C57BL/6J mice	5
Sleep deprivation and glymphatic dysfunction: Perspectives on the risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)	5
Insights into the effect of microgravity on phytopathogens and plant-associated microbes	5
Mimic microgravity effect on muscle transcriptome under ionizing radiation	5
Effects of neutron radiation on pharmaceuticals in deep space-like environments - general anesthesia in space	5
Space biological and human survival: Investigations into plants, animals, microorganisms and their components and bioregenerative life support systems	5
Lower body negative pressure as a research tool and countermeasure for the physiological effects of spaceflight: A comprehensive review	5
IFC - Editorial Board	5

Active radiation measurements over one solar cycle with two DOSTEL instruments in the Columbus laboratory of the International Space Station	5
Parabolic flight as a space-flight analogon impacts angiogenesis and lipid metabolism	5
Comparison of the particle flux measured by Liulin-MO dosimeter in ExoMars TGO science orbit with those calculated by models	5
Corrigendum to ‘RadLab: An open science resource for radiation studies relevant to human spaceflight’ Life Sciences in Space Research Volume 43, November 2024, Pages 29-34	5
Sleep deprivation and glymphatic system dysfunction as a risk factor for SANS during long-duration spaceflight	5
Advancements in health monitoring technologies for astronauts in deep space missions: A Review	5
Biomechanics of healthy subjects during exercise on a simulated vibration isolation and stabilization system	5
An emerging paradigm for scientific decision: the AI evaluation of space science projects	4
Combined irradiation by gamma-rays and carbon-12 nuclei caused hyperlocomotion and change in striatal metabolism of rats	4
Contemporary review of dermatologic conditions in space flight and future implications for long-duration exploration missions	4
IFC - Editorial Board	4
How do we transport plant species with desiccation-sensitive germplasm in space?	4
Differential regulation of mitochondrial quality control in skeletal muscle by HZE radiation exposure and partial weightbearing in mice	4
The lack of mass transfer in bone lacunar-canalicular system may be the decisive factor of osteoporosis under microgravity	4
Comparative analysis of the molecular response characteristics in Platycodon grandiflorus irradiated with heavy ion beams and X-rays	4
Biophysics of ophthalmic medications during spaceflight: Principles of ocular fluid dynamics and pharmacokinetics in microgravity	4
A non-invasive approach to monitor anemia during long-duration spaceflight with retinal fundus images and deep learning	4
Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model	4
Bone deconditioning during partial weight-bearing in rodents – A systematic review and meta-analysis	4
Non-targeted effects and space radiation risks for astronauts on multiple International Space Station and lunar missions	4
Treatment with a superoxide dismutase mimetic for joint preservation during 35 and 75 days in orbit aboard the international space station, and after 120 days recovery on Earth	4
The COSPAR planetary protection policy for missions to Icy Worlds: A review of history, current scientific knowledge, and future directions	4
The influence of simulated weightlessness on the composition and function of gut microbiota and bile acid metabolism products	4
RRx-001 and the “Right stuff”: Protection and treatment in outer space	4
Automated pupillometry in space neuroscience	4
High throughput screen of small molecules as potential countermeasures to galactic cosmic radiation induced cellular dysfunction	4
Non-DNA radiosensitive targets that initiate persistent behavioral deficits in rats exposed to space radiation	3
The brain-eye-liver axis during spaceflight: implications of hepatic dysfunction in spaceflight associated neuro-ocular syndrome	3
Space station and spacecraft environmental conditions and human mental health: Specific recommendations and guidelines	3
Medial prefrontal cortex and hippocampus in mice differently affected by simulate microgravity and social isolation associated with the alternation of emotional and cognitive functions	3
Celestial hazards: immunological and pulmonary effects of lunar and Martian regolith simulants	3
Molecular and biomechanical changes of the cornea and lens in spaceflight	3
Effects of social isolation alone and combined with15cGy GCRsim Space radiation on fear conditioned behavioral, stress and sleep responses	3
The ocular surface during spaceflight: Post-mission symptom report, extraterrestrial risks, and in-flight therapeutics	3
Human thermoregulation in microgravity environments: Insights from a computational model	3
Increase in steryl glycoside levels and stimulation of lipid raft formation in azuki bean epicotyls under hypergravity conditions	3
IFC - Editorial Board	3
Development of a NASA roadmap for planetary protection to prepare for the first human missions to Mars	3
A multilevel probabilistic dose response model for radiation-induced Harderian gland tumor prevalence–single beam and mixed field effects	3
Space radiation measured during first-ever commercial suborbital mission on Virgin Galactic SpaceShipTwo Unity on 29 June 2023	3
Dose-specific lncRNA–mRNA networks modulate DNA damage and immune responses in CD4⁺ T cells under simulated space UVC irradiation	3
Simulated Microgravity affects immune reaction to infection through altering lymphocyte differentiation, cytokine secretion, and macrophage polarization	3
In Memoriam	3
Harnessing nucleic acid technologies for human health on earth and in space	3
Integrated analysis of miRNAome and transcriptome reveals that microgravity induces the alterations of critical functional gene modules via the regulation of miRNAs in short-term space-flown C. elegan	3
HERA: A Timepix-based radiation detection system for Exploration-class space missions	3
Weighing the impact of microgravity on vestibular and visual functions	3
Exploring microgravity-induced changes to the coagulation system using thrombelastograph - a topical review	3
Food technologies for space missions	3
Space radiation and risk for ocular surface malignancies: Exposure risk, current mitigation strategies, and management considerations for a mission to Mars	3
Changes of iron dynamics in the duodenum and bone marrow under partial gravity condition in mice	3
Tryptophan metabolites are altered when Caco-2 cells are exposed to simulated microgravity	3
Effects of X-ray irradiation and housing conditions on mitochondria in Peromyscus maniculatus	2
Applicability of composite materials for space radiation shielding of spacecraft	2
Targeting hippocampal neurogenesis to protect astronauts’ cognition and mood from decline due to space radiation effects	2
Astrochemistry: The study of chemical processes in space	2
DNA decompaction enhances the formation of radiation-induced DNA double strand breaks and chromosome aberrations	2
Considerations for carcinogenesis countermeasure development using mouse models	2
Characteristics of blood plasma proteome changes associated with the hemorrhagic purpura of cosmonauts on the first day after long-term space missions	2
3D bioprinting meniscus tissue onboard the International Space Station	2
Protective effect of Gastrodia elata blume ameliorates simulated weightlessness-induced cognitive impairment in mice	2
Effects of hypobaria, hyperoxia, and nitrogen form on the growth and nutritional quality of lettuce	2
Carbonate precipitation and nitrogen fixation in AMG (Artificial Martian Ground) by cyanobacteria	2
Gypsophytes and the use of Martian Gypsum: A review of their potential for agriculture on Mars	2
Exposing Drosophila to wheat-derived microbes enhances its immunity and survival under simulated microgravity	2
Goldfish regenerated scale culture at low temperatures improves osteoblast and osteoclast survival in scales without loss of the osteoblast and osteoclast response to changes in gravity	2
Limb position sense and sensorimotor performance under conditions of weightlessness	2
Decreased myocardial glucose uptake precedes cardiac dysfunction in hindlimb unloading mice revealed by dynamic 18F-FDG PET imaging	2
Dynamic visual acuity as a biometric for astronaut performance and safety	2
Reduced set-shifting processing speed in male rats following low dose (10 cGy) proton exposure	2
Galactic cosmic ray simulation at the NASA space radiation laboratory – Progress, challenges and recommendations on mixed-field effects	2
Advanced food packaging systems for space exploration missions	2
Amorphous calcium carbonate enhances osteogenic differentiation and myotube formation of human bone marrow derived mesenchymal stem cells and primary skeletal muscle cells under microgravity condition	2
Crew time in a space greenhouse using data from analog missions and Veggie	2
The COSPAR planetary protection requirements for space missions to Venus	2
Corrigendum to “Characterization of virulence-related phenotypes of Candida parapsilosis and Rhodotorula mucilaginosa isolated from the International Space Station (ISS)” [Life Sciences in Space Resea	2
Radiation cataract in Heterogeneous Stock mice after γ-ray or HZE ion exposure	2
Cultivation and nutritional characteristics of Chlorella vulgaris cultivated using Martian regolith and synthetic urine	2
Characterization of virulence-related phenotypes of Candida parapsilosis and Rhodotorula mucilaginosa isolated from the International Space Station (ISS)	2
Analytical calculation of the dose to a spherical target by an ion at almost all impact parameters, and calculation of the energy deposition spectra	1

Extended reality quantification of pupil reactivity as a non-invasive assessment for the pathogenesis of spaceflight associated neuro-ocular syndrome: A technology validation study for astronaut healt	1
Leaf yield and mineral content of mizuna in response to cut-and-come-again harvest, substrate particle size, and fertilizer formulation in a simulated spaceflight environment	1
Hydroponics for plant cultivation in space – a white paper	1
Research on the effects of 15-day of head-down tilt bed rest on arterial hemodynamics and blood supply using Doppler ultrasound technology	1
X-ray-downregulated nucleophosmin induces abnormal polarization by anchoring to G-actin	1
Application of functional microbial agent in aerobic composting of wheat straw for waste recycling	1
Radiation in human space exploration: Detectors and measurements, today and tomorrow	1
The effect of Hydrogen-rich water on retinal degeneration in the outer nuclear layer of simulated weightlessness rats	1
Private Spaceflight: A New Landscape for Dealing with Medical Risk	1
Neurostimulation as a technology countermeasure for dry eye syndrome in astronauts	1
Recent observational studies on carbon-chain species with current facilities and future prospects with ALMA & JWST	1
10-min exposure to a 2.5% hypercapnic environment increases cerebral blood blow but does not impact executive function	1
Baoyuan jieyu formula ameliorates depression-like behaviour in rats induced by simulated long-term spaceflight composite stress through regulating MAPK and BDNF pathways	1
Monte Carlo simulation of semiconductor-based detector in mixed radiation field in the atmosphere	1
The microwave electromagnetic background as measured onboard the International Space Station	1
Mechanical interaction of myosin and native thin filament in the disused rat soleus muscle	1
Regulatory measures for mitigating physical and mental health impacts in aerospace environment: A systematic review	1
Palmer Station, Antarctica: A ground-based spaceflight analog suitable for validation of biomedical countermeasures for deep space missions	1
Combined effects of heavy ion exposure and simulated Lunar gravity on skeletal muscle	1
Microgravity as a contributing factor to venous thromboembolism development: Risks and prevention strategies	1
Effects of the space environment and re-adaptation to Earth's gravity on astronauts' plasma proteome	1
Gastrodia elata blume ameliorates circadian rhythm disorder-induced mice memory impairment	1
Dose measurements with the Pille-ISS thermoluminescent dosimeter system during extravehicular activities (2004-2022)	1
Recent developments in space food for exploration missions: A review	1
Design and establishment of a large-scale controlled ecological life-support system integrated experimental platform	1
A novel device to study altered gravity and light interactions in seedling tropisms	1
Lunar dust induces minimal pulmonary toxicity compared to Earth dust	1
Effects of preexposure to a subthreshold dose of helium particles on the changes in performance produced by exposure to helium particles	1
Microglia: Rheostats of space radiation effects in the CNS microenvironment	1
Compact portable sources of high-LET radiation: Validation and potential application for galactic cosmic radiation countermeasure discovery	1
Corrigendum to ‘Review of research into bioregenerative life support system(s) which can support humans living in space’ [life sciences in space research 31 (2021) 113–120]	1
Stability of ice-embedded glycine under space ionizing radiations: a RT-TD-DFT and DFT study	1
Activation of the visual system by space radiation: A novel study on Ca2+ signalling in ex-vivo rabbit eyes exposed to visible light, X-rays and high-energy protons	1