OOIR: Observatory of International Research

Papers

(The median citation count of Life Sciences in Space Research is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
Investigation of shielding material properties for effective space radiation protection	55
A review of astronaut mental health in manned missions: Potential interventions for cognitive and mental health challenges	31
Limnospira indica PCC8005 growth in photobioreactor: model and simulation of the ISS and ground experiments	31
Biology and crop production in Space environments: Challenges and opportunities	23
Applicability of composite materials for space radiation shielding of spacecraft	23
The effects of microgravity on the digestive system and the new insights it brings to the life sciences	23
Plant biology for space exploration – Building on the past, preparing for the future	21
Review of research into bioregenerative life support system(s) which can support humans living in space	19
Plant responses to real and simulated microgravity	17
Growth and photosynthetic responses of Chinese cabbage (Brassica rapa L. cv. Tokyo Bekana) to continuously elevated carbon dioxide in a simulated Space Station “Veggie” crop-production environment	17
A proposed change to astronaut exposures limits is a giant leap backwards for radiation protection	16
Thick shielding against galactic cosmic radiation: A Monte Carlo study with focus on the role of secondary neutrons	16
A non-invasive approach to monitor anemia during long-duration spaceflight with retinal fundus images and deep learning	16
Negative impact of disuse and unloading on tendon enthesis structure and function	15
Updated deterministic radiation transport for future deep space missions	15
Predictions of cognitive detriments from galactic cosmic ray exposures to astronauts on exploration missions	15
Recent developments in space food for exploration missions: A review	15
Lignocellulose degradation, biogas production and characteristics of the microbial community in solid-state anaerobic digestion of wheat straw waste	14
Heavy ion space radiation triggers ongoing DNA base damage by downregulating DNA repair pathways	13
Small tissue chips with big opportunities for space medicine	13
Improving astronaut cancer risk assessment from space radiation with an ensemble model framework	13
Gastrodia elata blume ameliorates circadian rhythm disorder-induced mice memory impairment	13
Simultaneous exposure to chronic irradiation and simulated microgravity differentially alters immune cell phenotype in mouse thymus and spleen	12
Benchmarking risk predictions and uncertainties in the NSCR model of GCR cancer risks with revised low let risk coefficients	12
Reversing radiation-induced immunosuppression using a new therapeutic modality	11

CultCube: Experiments in autonomous in-orbit cultivation on-board a 12-Units CubeSat platform	11
Identification of interstellar amino acetonitrile in the hot molecular core G10.47＋0.03: Possible glycine survey candidate for the future	11
Long term food stability for extended space missions: a review	11
Simulating galactic cosmic ray effects: Synergy modeling of murine tumor prevalence after exposure to two one-ion beams in rapid sequence	11
Galactic cosmic ray simulation at the NASA space radiation laboratory – Progress, challenges and recommendations on mixed-field effects	10
Transfer learning as an AI-based solution to address limited datasets in space medicine	10
The associations of geomagnetic storms, fast solar wind, and stream interaction regions with cardiovascular characteristic in patients with acute coronary syndrome	10
The COSPAR Planetary Protection Policy for robotic missions to Mars: A review of current scientific knowledge and future perspectives	10
Advanced food packaging systems for space exploration missions	9
Dynamic visual acuity as a biometric for astronaut performance and safety	9
Private Spaceflight: A New Landscape for Dealing with Medical Risk	9
Crew time and workload in the EDEN ISS greenhouse in Antarctica	9
RRx-001 and the “Right stuff”: Protection and treatment in outer space	9
Extended reality quantification of pupil reactivity as a non-invasive assessment for the pathogenesis of spaceflight associated neuro-ocular syndrome: A technology validation study for astronaut healt	9
Proteomic analysis in different development stages on SP0 generation of rice seeds after space flight	9
Transient cerebral blood flow responses during microgravity	9
Effects of LED spectra on growth, gas exchange, antioxidant activity and nutritional quality of vegetable species	9
Survival of desert algae Chlorella exposed to Mars-like near space environment	9
Impact of galactic cosmic ray simulation on nutritional content of foods	8
Effects of single-dose protons or oxygen ions on function and structure of the cardiovascular system in male Long Evans rats	8
Aquatic invertebrate protein sources for long-duration space travel	8
A novel device to study altered gravity and light interactions in seedling tropisms	8
The Need for Biological Countermeasures to Mitigate the Risk of Space Radiation-Induced Carcinogenesis, Cardiovascular Disease, and Central Nervous System Deficiencies	8
Effects of dietary aspirin on high-LET radiation-induced prostaglandin E2 levels and gastrointestinal tumorigenesis in Apc mice	8
What can space radiation protection learn from radiation oncology?	8
Application of functional microbial agent in aerobic composting of wheat straw for waste recycling	7
NDVI imaging within space exploration plant growth modules – A case study from EDEN ISS Antarctica	7
The lack of mass transfer in bone lacunar-canalicular system may be the decisive factor of osteoporosis under microgravity	7
Cancer incidence risks above and below 1 Gy for radiation protection in space	7
Exercise and Testosterone Countermeasures to Mitigate Metabolic Changes during Bed Rest	7
Population analysis of space travelers	7
The neurology of space flight; How does space flight effect the human nervous system?	7
Subsequent inclusion/exclusion criteria to select the best species for an experiment performed on the ISS in a refurbished hardware	6
Targeting hippocampal neurogenesis to protect astronauts’ cognition and mood from decline due to space radiation effects	6
Crew time in a space greenhouse using data from analog missions and Veggie	6
Multiple sensory illusions are evoked during the course of proton therapy	6
CRaTER observations and permissible mission duration for human operations in deep space	6
Extracellular vesicles-derived microRNAs expression as biomarkers for neurological radiation injury: Risk assessment for space exploration	6
Characterization of exosome release and extracellular vesicle-associated miRNAs for human bronchial epithelial cells irradiated with high charge and energy ions	6
Effects of partial- or whole-body exposures to 56Fe particles on brain function and cognitive performance in rats	6
Assessment of Spaceflight Medical Conditions’ and Treatments’ Potential Impacts on Behavioral Health and Performance	6
Limb position sense and sensorimotor performance under conditions of weightlessness	6
Space radiation does not alter amyloid or tau pathology in the 3xTg mouse model of Alzheimer's disease	6
Baoyuan jieyu formula ameliorates depression-like behaviour in rats induced by simulated long-term spaceflight composite stress through regulating MAPK and BDNF pathways	6
Blood flow in the internal jugular veins during the spaceflight – Is it actually bidirectional?	6
Pattern of the variation of the TEC extracted from the GPS, IRI 2016, IRI-Plas 2017 and NeQuick 2 over polar region, Antarctica	6
Comparison of two controlled-release fertilizer formulations for cut-and-come-again harvest yield and mineral content of Lactuca sativa L. cv. Outredgeous grown under International Space Station envir	6
Simulated weightlessness induces cognitive changes in rats illustrated by performance in operant conditioning tasks	6
Spaceflight validation of technology for point-of-care monitoring of peripheral blood WBC and differential in astronauts during space missions	6
Phenotypic and transcriptional changes in Escherichia coli K12 in response to simulated microgravity on the EagleStat, a new 2D microgravity analog for bacterial studies.	5

Comparison between PHITS and GEANT4 Simulations of the Heavy Ion Beams at the BEVALAC at LBNL and the Booster Accelerator at BNL	5
A new type of ground-based simulator of radiation field inside a spacecraft in deep space	5
Particle radiation-induced dysregulation of protein homeostasis in primary human and mouse neuronal cells	5
Calculation of dose distribution in a realistic brain structure and the indication of space radiation influence on human brains	5
Suppression of endoplasmic reticulum stress prevents disuse muscle atrophy in a mouse model of microgravity	5
Semi-continuous fermentation of solid waste in closed artificial ecosystem: Microbial diversity, function genes evaluation	5
Looking on the horizon; potential and unique approaches to developing radiation countermeasures for deep space travel	5
Zoster patients on earth and astronauts in space share similar immunologic profiles	5
Effects of stepwise changes in dissolved carbon dioxide concentrations on metabolic activity in Chlorella for spaceflight applications	5
Real versus simulated galactic cosmic radiation for investigating cancer risk in the hematopoietic system - are we comparing apples to apples?	5
New evidence and insight for abnormalities in early embryonic development after short-term spaceflight onboard the Chinese SJ-10 satellite	5
Inhibition of SIRT1 by miR-138-5p provides a mechanism for inhibiting osteoblast proliferation and promoting apoptosis under simulated microgravity	4
Medial prefrontal cortex and hippocampus in mice differently affected by simulate microgravity and social isolation associated with the alternation of emotional and cognitive functions	4
Angiotensin converting enzyme (ACE) inhibitors as radiation countermeasures for long-duration space flights	4
Comparative study of methods for detecting extraterrestrial life in exploration mission of Mars and the solar system	4
Operation overview of a biological waste treatment system during the 4-crew 180-day integrated experiment in the controlled ecological life support system (CELSS)	4
Comparison of signaling profiles in the low dose range following low and high LET radiation	4
Investigating alterations in the cellular envelope of Staphylococcus aureus in simulated microgravity using a random positioning machine	4
Microbial diversity formation and maintenance due to temporal niche differentiation caused by low-dose ionizing radiation in oligotrophic environments	4
Long-term pharmacological torpor of rats with feedback-controlled drug administration	4
Hybrid methods of radiation shielding against deep-space radiation	4
Microarray profile of gene expression in etiolated Pisum sativum seedlings grown under microgravity conditions in space: Relevance to the International Space Station experiment “Auxin Transport”	4
Proteomic analysis of the effects of simulated microgravity in human gastric mucosal cells	3
Mouse genomic associations with in vitro sensitivity to simulated space radiation	3
The COSPAR planetary protection requirements for space missions to Venus	3
Tunable spectrum resemblance of LED lights for improving the photosynthetic action of Chinese Cabbages	3
Clinical Trial in a Dish for Space Radiation Countermeasure Discovery	3
Mitigation of late cardiovascular effects of oxygen ion radiation by γ-tocotrienol in a mouse model	3
Observation of the radiation environment and solar energetic particle events in Mars orbit in May 2018- June 2022	3
Accelerating space radiation countermeasure development through drug repurposing	3
Simulated microgravity accelerates aging in Saccharomyces cerevisiae	3
Effects of short-term hypergravity on hematopoiesis and vasculogenesis in embryonic zebrafish	3
High throughput screen of small molecules as potential countermeasures to galactic cosmic radiation induced cellular dysfunction	3
Modeling a lunar base mushroom farm	3
Effects of the Serber first step in 3DHZETRN-v2.1	3
Optimized crop growth area composition for long duration spaceflight	3
Effects of low-dose oxygen ions on cardiac function and structure in female C57BL/6J mice	3
Nonhuman primate models in the study of spaceflight stressors: Past contributions and future directions	3
Observations of neutron radiation environment during Odyssey cruise to Mars	3
Microgravity alters the expressions of DNA repair genes and their regulatory miRNAs in space-flown Caenorhabditis elegans	3
Development of a NASA roadmap for planetary protection to prepare for the first human missions to Mars	3
Medical countermeasures for the hematopoietic-subsyndrome of acute radiation syndrome in space	3
Effects of the geomagnetic field time–varying components compensation as evidenced by heart rate variability of healthy males.	3
Solar modulation of the GCR flux and dose rate, observed in space between 1991 and 2019	3
Effect of reduced atmospheric pressure on growth and quality of two lettuce cultivars	3
High-throughput screening strategies for space-based radiation countermeasure discovery	3
Bioregenerative life support space diet and nutrition requirements: still seeking accord	3
Comprehensive analyses of plant hormones in etiolated pea and maize seedlings grown under microgravity conditions in space: Relevance to the International Space Station experiment “Auxin Transport”	3
Galactic cosmic ray environment predictions for the NASA BioSentinel mission	3
Effects of simulated microgravity and vibration on osteoblast and osteoclast activity in cultured zebrafish scales	3