OOIR: Observatory of International Research

Papers

(The median citation count of Life Sciences in Space Research is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
IFC - Editorial Board	33
Effect of countermeasure bodygear on cardiac-vascular-respiratory coupling during 6-degree head-down tilt: An earth-based microgravity study	32
Biofilm dynamics in space and their potential for sustainable space exploration – A comprehensive review	29
Anthocyanin can improve the survival of rice seeds from solar light outside the international space station	27
Challenges and innovations in food and water availability for a sustainable Mars colonization	24
Organ dose equivalents of albedo protons and neutrons under exposure to large solar particle events during lunar human landing missions	23
3D culture and cryopreservation/thawing strategy of human induced pluripotent stem cells for spaceflight experiments	23
IFC - Editorial Board	21
IFC - Editorial Board	20
The case for anterior segment optical coherence tomography (AS-OCT) for the international space station and future planetary spaceflight: Clinical relevance and technical implementation	19
RadLab: An open science resource for radiation studies relevant to human spaceflight	19
Residual radiation risk disparities across sex and race or ethnic groups for lifetime never-smokers on lunar missions	19
Results from the Radiation Assessment Detector on the International Space Station: Part 1, the Charged Particle Detector	18
A no-fault risk compensation approach for radiation risks incurred in space travel	18
Lignocellulose degradation, biogas production and characteristics of the microbial community in solid-state anaerobic digestion of wheat straw waste	17
Reorganization of the mouse oocyte' cytoskeleton after cultivation under simulated weightlessness	17
Radiation environment on TGO Mars orbit during solar particle events in January–October 2024. Corresponding solar eruptions and GOES proton fluxes data	16
Construction of microgravity biological knowledge graph and its applications in anti-osteoporosis drug prediction	16
Analysis of suitable site candidates for Mars human habitat and life-support technologies based on in situ water resource utilization	16
Optimizing autonomous artificial intelligence diagnostics for neuro-ocular health in space missions	16
Galactic cosmic ray environment predictions for the NASA BioSentinel Mission, part 2:Post-mission validation	15
Behavior of simple closed ecological systems; lower nutrient concentrations allow longer persistence of grazer populations	14
Disparity in the effect of partial gravity simulated using a new apparatus on different rat hindlimb muscles	14
Comparative study of methods for detecting extraterrestrial life in exploration mission of Mars and the solar system	14
Infrared spectroscopy reveals ethylene glycol is an anti-crystallizer in water mixed astrochemical ices	13

The neurology of space flight; How does space flight effect the human nervous system?	12
Study on primary physicochemical characteristics and nutrient adsorption of four plant cultivation substrates	11
Recent progresses on space life science research in China	11
A method to predict space radiation biological effectiveness for non-cancer effects following intense Solar Particle Events	10
Angiotensin converting enzyme (ACE) inhibitors as radiation countermeasures for long-duration space flights	10
The COSPAR Planetary Protection Policy for robotic missions to Mars: A review of current scientific knowledge and future perspectives	10
Transfer learning as an AI-based solution to address limited datasets in space medicine	10
Accumulation of high-energy phosphates blocks the expression of mitochondrial biogenesis markers and slow-type myosin in soleus muscle under 24 hours of rat hindlimb suspension	10
High-throughput screening strategies for space-based radiation countermeasure discovery	10
Involvement of KATANIN1, a microtubule-severing enzyme, in hypergravity-induced modification of growth anisotropy in Arabidopsis hypocotyls	10
IFC - Editorial Board	9
Impact of weightlessness on dynamic deformation and haemodynamic parameters of the heart	9
Tissue-specific dose equivalents of secondary mesons and leptons during galactic cosmic ray exposures for mars exploration	9
Pinoresinol diglucoside alleviates hindlimb unloading-induced bone loss in mice	9
Integrated spaceflight transcriptomic analyses and simulated space experiments reveal key molecular features and functional changes driven by space stressors in space-flown C. elegans	9
Simulated microgravity altered the gene expression profiles and inhibited the proliferation of Kupffer cells in the early phase by downregulating LMO2 and EZH2	9
IFC - Editorial Board	8
Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading	8
Medical countermeasures for the hematopoietic-subsyndrome of acute radiation syndrome in space	7
Simulated space environmental factors of weightlessness, noise and low atmospheric pressure differentially affect the diurnal rhythm and the gut microbiome	7
Microbes and nutrient shift in a Closed Aquatic Ecosystem (CAES) during four weeks of operation	7
Effects of social isolation and galactic cosmic radiation on fine motor skills and behavioral performance	7
Results from the Radiation Assessment Detector on the International Space Station, Part 2: The fast neutron detector	7
Small tissue chips with big opportunities for space medicine	7
Solid waste management and resource recovery during the 4-crew 180-day CELSS integrated experiment	6
Active radiation measurements over one solar cycle with two DOSTEL instruments in the Columbus laboratory of the International Space Station	6
Sleep deprivation and glymphatic dysfunction: Perspectives on the risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)	6
Parabolic flight as a research platform to investigate ophthalmic changes in microgravity	6
Spaceflight validation of technology for point-of-care monitoring of peripheral blood WBC and differential in astronauts during space missions	6
IFC - Editorial Board	6
Parabolic flight as a space-flight analogon impacts angiogenesis and lipid metabolism	6
Reduced gravity effects on gait coordinative structures	6
Evolving radiological protection guidelines for exploration-class missions	6
IFC - Editorial Board	6
Leveraging lower body negative pressure for enhanced outcomes in orthopedic arthroplasty—Insights from NASA’s bone health research	6
IFC - Editorial Board	5
IFC - Editorial Board	5
Comparison of the particle flux measured by Liulin-MO dosimeter in ExoMars TGO science orbit with those calculated by models	5
Lower body negative pressure as a research tool and countermeasure for the physiological effects of spaceflight: A comprehensive review	5
Biomechanics of healthy subjects during exercise on a simulated vibration isolation and stabilization system	5
Relationship of collagen as the component of the extracellular matrix with the mechanisms of autonomic regulation of the cardiovascular system under simulated conditions of long-term isolation	5
IFC - Editorial Board	5
Sleep deprivation and glymphatic system dysfunction as a risk factor for SANS during long-duration spaceflight	5
Cardiovascular adaptations in microgravity conditions	5
Mimic microgravity effect on muscle transcriptome under ionizing radiation	5
Insights into the effect of microgravity on phytopathogens and plant-associated microbes	5
Space biological and human survival: Investigations into plants, animals, microorganisms and their components and bioregenerative life support systems	5
A non-invasive approach to monitor anemia during long-duration spaceflight with retinal fundus images and deep learning	5
Effects of low-dose oxygen ions on cardiac function and structure in female C57BL/6J mice	5
Improving astronaut cancer risk assessment from space radiation with an ensemble model framework	5

Corrigendum to ‘RadLab: An open science resource for radiation studies relevant to human spaceflight’ Life Sciences in Space Research Volume 43, November 2024, Pages 29-34	5
Effects of neutron radiation on pharmaceuticals in deep space-like environments - general anesthesia in space	5
Space station and spacecraft environmental conditions and human mental health: Specific recommendations and guidelines	4
Harnessing nucleic acid technologies for human health on earth and in space	4
Development of a NASA roadmap for planetary protection to prepare for the first human missions to Mars	4
Space radiation measured during first-ever commercial suborbital mission on Virgin Galactic SpaceShipTwo Unity on 29 June 2023	4
Combined irradiation by gamma-rays and carbon-12 nuclei caused hyperlocomotion and change in striatal metabolism of rats	4
High throughput screen of small molecules as potential countermeasures to galactic cosmic radiation induced cellular dysfunction	4
Automated pupillometry in space neuroscience	4
RRx-001 and the “Right stuff”: Protection and treatment in outer space	4
Contemporary review of dermatologic conditions in space flight and future implications for long-duration exploration missions	4
Biophysics of ophthalmic medications during spaceflight: Principles of ocular fluid dynamics and pharmacokinetics in microgravity	4
Food technologies for space missions	4
Medial prefrontal cortex and hippocampus in mice differently affected by simulate microgravity and social isolation associated with the alternation of emotional and cognitive functions	4
Weighing the impact of microgravity on vestibular and visual functions	4
How do we transport plant species with desiccation-sensitive germplasm in space?	4
The influence of simulated weightlessness on the composition and function of gut microbiota and bile acid metabolism products	4
Treatment with a superoxide dismutase mimetic for joint preservation during 35 and 75 days in orbit aboard the international space station, and after 120 days recovery on Earth	4
Non-targeted effects and space radiation risks for astronauts on multiple International Space Station and lunar missions	4
The COSPAR planetary protection policy for missions to Icy Worlds: A review of history, current scientific knowledge, and future directions	4
Molecular and biomechanical changes of the cornea and lens in spaceflight	4
The lack of mass transfer in bone lacunar-canalicular system may be the decisive factor of osteoporosis under microgravity	4
Comparative analysis of the molecular response characteristics in Platycodon grandiflorus irradiated with heavy ion beams and X-rays	4
Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model	4
Bone deconditioning during partial weight-bearing in rodents – A systematic review and meta-analysis	4
The ocular surface during spaceflight: Post-mission symptom report, extraterrestrial risks, and in-flight therapeutics	3
Integrated analysis of miRNAome and transcriptome reveals that microgravity induces the alterations of critical functional gene modules via the regulation of miRNAs in short-term space-flown C. elegan	3
Non-DNA radiosensitive targets that initiate persistent behavioral deficits in rats exposed to space radiation	3
Limb position sense and sensorimotor performance under conditions of weightlessness	3
Human thermoregulation in microgravity environments: Insights from a computational model	3
Cultivation and nutritional characteristics of Chlorella vulgaris cultivated using Martian regolith and synthetic urine	3
Changes of iron dynamics in the duodenum and bone marrow under partial gravity condition in mice	3
In Memoriam	3
Considerations for carcinogenesis countermeasure development using mouse models	3
Dynamic visual acuity as a biometric for astronaut performance and safety	3
Tryptophan metabolites are altered when Caco-2 cells are exposed to simulated microgravity	3
HERA: A Timepix-based radiation detection system for Exploration-class space missions	3
Increase in steryl glycoside levels and stimulation of lipid raft formation in azuki bean epicotyls under hypergravity conditions	3
Protective effect of Gastrodia elata blume ameliorates simulated weightlessness-induced cognitive impairment in mice	3
Characteristics of blood plasma proteome changes associated with the hemorrhagic purpura of cosmonauts on the first day after long-term space missions	3
Radiation cataract in Heterogeneous Stock mice after γ-ray or HZE ion exposure	3
Corrigendum to “Characterization of virulence-related phenotypes of Candida parapsilosis and Rhodotorula mucilaginosa isolated from the International Space Station (ISS)” [Life Sciences in Space Resea	3
Stability of ice-embedded glycine under space ionizing radiations: a RT-TD-DFT and DFT study	2
Recent observational studies on carbon-chain species with current facilities and future prospects with ALMA & JWST	2
Targeting hippocampal neurogenesis to protect astronauts’ cognition and mood from decline due to space radiation effects	2
Characterization of virulence-related phenotypes of Candida parapsilosis and Rhodotorula mucilaginosa isolated from the International Space Station (ISS)	2
Effects of X-ray irradiation and housing conditions on mitochondria in Peromyscus maniculatus	2
The COSPAR planetary protection requirements for space missions to Venus	2
Gastrodia elata blume ameliorates circadian rhythm disorder-induced mice memory impairment	2
The microwave electromagnetic background as measured onboard the International Space Station	2
Application of functional microbial agent in aerobic composting of wheat straw for waste recycling	2
Neurostimulation as a technology countermeasure for dry eye syndrome in astronauts	2
Effects of preexposure to a subthreshold dose of helium particles on the changes in performance produced by exposure to helium particles	2
Carbonate precipitation and nitrogen fixation in AMG (Artificial Martian Ground) by cyanobacteria	2
Astrochemistry: The study of chemical processes in space	2
Galactic cosmic ray simulation at the NASA space radiation laboratory – Progress, challenges and recommendations on mixed-field effects	2
Goldfish regenerated scale culture at low temperatures improves osteoblast and osteoclast survival in scales without loss of the osteoblast and osteoclast response to changes in gravity	2
Palmer Station, Antarctica: A ground-based spaceflight analog suitable for validation of biomedical countermeasures for deep space missions	2
Leaf yield and mineral content of mizuna in response to cut-and-come-again harvest, substrate particle size, and fertilizer formulation in a simulated spaceflight environment	2
The effect of Hydrogen-rich water on retinal degeneration in the outer nuclear layer of simulated weightlessness rats	2
Microgravity as a contributing factor to venous thromboembolism development: Risks and prevention strategies	2
Applicability of composite materials for space radiation shielding of spacecraft	2
Amorphous calcium carbonate enhances osteogenic differentiation and myotube formation of human bone marrow derived mesenchymal stem cells and primary skeletal muscle cells under microgravity condition	2
3D bioprinting meniscus tissue onboard the International Space Station	2
Effects of hypobaria, hyperoxia, and nitrogen form on the growth and nutritional quality of lettuce	2
Compact portable sources of high-LET radiation: Validation and potential application for galactic cosmic radiation countermeasure discovery	2
Reduced set-shifting processing speed in male rats following low dose (10 cGy) proton exposure	2
Advanced food packaging systems for space exploration missions	2
Crew time in a space greenhouse using data from analog missions and Veggie	2
Baoyuan jieyu formula ameliorates depression-like behaviour in rats induced by simulated long-term spaceflight composite stress through regulating MAPK and BDNF pathways	2