OOIR: Observatory of International Research

Papers

(The median citation count of Life Sciences in Space Research is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 500 papers]. The publications cover those that have been published in the past four years, i.e., from 2019-11-01 to 2023-11-01.)

Article	Citations
Investigation of shielding material properties for effective space radiation protection	45
Regenerative water purification for space applications: Needs, challenges, and technologies towards 'closing the loop'	34
Limnospira indica PCC8005 growth in photobioreactor: model and simulation of the ISS and ground experiments	28
A review of astronaut mental health in manned missions: Potential interventions for cognitive and mental health challenges	26
EcAMSat spaceflight measurements of the role of σs in antibiotic resistance of stationary phase Escherichia coli in microgravity	25
Biology and crop production in Space environments: Challenges and opportunities	20
Assessment of the probability of microbial contamination for sample return from Martian moons II: The fate of microbes on Martian moons	19
High density long-term cultivation of Chlorella vulgaris SAG 211-12 in a novel microgravity-capable membrane raceway photobioreactor for future bioregenerative life support in SPACE	19
Plant biology for space exploration – Building on the past, preparing for the future	17
Applicability of composite materials for space radiation shielding of spacecraft	17
Effect of simulated microgravity and ionizing radiation on expression profiles of miRNA, lncRNA, and mRNA in human lymphoblastoid cells	16
Review of research into bioregenerative life support system(s) which can support humans living in space	15
Plant responses to real and simulated microgravity	14
Predictions of cognitive detriments from galactic cosmic ray exposures to astronauts on exploration missions	14
A proposed change to astronaut exposures limits is a giant leap backwards for radiation protection	14
The effects of microgravity on the digestive system and the new insights it brings to the life sciences	14
Lignocellulose degradation, biogas production and characteristics of the microbial community in solid-state anaerobic digestion of wheat straw waste	13
Synergistic effects of edible plants with light environment on the emotion and sleep of humans in long-duration isolated environment	13
Beyond planetary protection: What is planetary sustainability and what are its implications for space research?	13
Heavy ion space radiation triggers ongoing DNA base damage by downregulating DNA repair pathways	13
Assessment of the probability of microbial contamination for sample return from Martian moons I: Departure of microbes from Martian surface	13
A summary on cutting edge advancements in sterilization and cleaning technologies in medical, food, and drug industries, and its applicability to spacecraft hardware	12
Simultaneous exposure to chronic irradiation and simulated microgravity differentially alters immune cell phenotype in mouse thymus and spleen	12
Growth and photosynthetic responses of Chinese cabbage (Brassica rapa L. cv. Tokyo Bekana) to continuously elevated carbon dioxide in a simulated Space Station “Veggie” crop-production environment	12
Benchmarking risk predictions and uncertainties in the NSCR model of GCR cancer risks with revised low let risk coefficients	12

Improving astronaut cancer risk assessment from space radiation with an ensemble model framework	12
Simulating galactic cosmic ray effects: Synergy modeling of murine tumor prevalence after exposure to two one-ion beams in rapid sequence	11
A non-invasive approach to monitor anemia during long-duration spaceflight with retinal fundus images and deep learning	11
Gastrodia elata blume ameliorates circadian rhythm disorder-induced mice memory impairment	11
Changes of brain DTI in healthy human subjects after 520 days isolation and confinement on a simulated mission to Mars	11
Negative impact of disuse and unloading on tendon enthesis structure and function	11
CultCube: Experiments in autonomous in-orbit cultivation on-board a 12-Units CubeSat platform	10
Small tissue chips with big opportunities for space medicine	9
Proteomic analysis in different development stages on SP0 generation of rice seeds after space flight	9
Thick shielding against galactic cosmic radiation: A Monte Carlo study with focus on the role of secondary neutrons	9
Updated deterministic radiation transport for future deep space missions	9
RRx-001 and the “Right stuff”: Protection and treatment in outer space	9
Transient cerebral blood flow responses during microgravity	8
Survival of desert algae Chlorella exposed to Mars-like near space environment	8
The associations of geomagnetic storms, fast solar wind, and stream interaction regions with cardiovascular characteristic in patients with acute coronary syndrome	8
Effects of single-dose protons or oxygen ions on function and structure of the cardiovascular system in male Long Evans rats	8
Crew time and workload in the EDEN ISS greenhouse in Antarctica	8
Effects of dietary aspirin on high-LET radiation-induced prostaglandin E2 levels and gastrointestinal tumorigenesis in Apc mice	8
Long term food stability for extended space missions: a review	8
NDVI imaging within space exploration plant growth modules – A case study from EDEN ISS Antarctica	7
Lung cancer progression using fast switching multiple ion beam radiation and countermeasure prevention	7
Acute radiation risk assessment and mitigation strategies in near future exploration spaceflights	7
Effects of LED spectra on growth, gas exchange, antioxidant activity and nutritional quality of vegetable species	7
A novel device to study altered gravity and light interactions in seedling tropisms	7
What can space radiation protection learn from radiation oncology?	7
Cancer incidence risks above and below 1 Gy for radiation protection in space	7
Reversing radiation-induced immunosuppression using a new therapeutic modality	7
Aquatic invertebrate protein sources for long-duration space travel	7
Private Spaceflight: A New Landscape for Dealing with Medical Risk	7
Identification of interstellar amino acetonitrile in the hot molecular core G10.47＋0.03: Possible glycine survey candidate for the future	7
Advanced food packaging systems for space exploration missions	7
Population analysis of space travelers	6
Galactic cosmic ray simulation at the NASA space radiation laboratory – Progress, challenges and recommendations on mixed-field effects	6
Radiation environment created with GCRs inside a spacecraft	6
CRaTER observations and permissible mission duration for human operations in deep space	6
Exercise and Testosterone Countermeasures to Mitigate Metabolic Changes during Bed Rest	6
Characterization of exosome release and extracellular vesicle-associated miRNAs for human bronchial epithelial cells irradiated with high charge and energy ions	6
Pattern of the variation of the TEC extracted from the GPS, IRI 2016, IRI-Plas 2017 and NeQuick 2 over polar region, Antarctica	6
Recent developments in space food for exploration missions: A review	6
Space radiation does not alter amyloid or tau pathology in the 3xTg mouse model of Alzheimer's disease	6
Application of functional microbial agent in aerobic composting of wheat straw for waste recycling	6
The lack of mass transfer in bone lacunar-canalicular system may be the decisive factor of osteoporosis under microgravity	6
The COSPAR Planetary Protection Policy for robotic missions to Mars: A review of current scientific knowledge and future perspectives	6
Multiple sensory illusions are evoked during the course of proton therapy	6
Extracellular vesicles-derived microRNAs expression as biomarkers for neurological radiation injury: Risk assessment for space exploration	6
Suppression of endoplasmic reticulum stress prevents disuse muscle atrophy in a mouse model of microgravity	5
Semi-continuous fermentation of solid waste in closed artificial ecosystem: Microbial diversity, function genes evaluation	5
Real versus simulated galactic cosmic radiation for investigating cancer risk in the hematopoietic system - are we comparing apples to apples?	5
A new type of ground-based simulator of radiation field inside a spacecraft in deep space	5
Calculation of dose distribution in a realistic brain structure and the indication of space radiation influence on human brains	5

Effects of partial- or whole-body exposures to 56Fe particles on brain function and cognitive performance in rats	5
Impact of galactic cosmic ray simulation on nutritional content of foods	5
Particle radiation-induced dysregulation of protein homeostasis in primary human and mouse neuronal cells	5
Spaceflight validation of technology for point-of-care monitoring of peripheral blood WBC and differential in astronauts during space missions	5
Targeting hippocampal neurogenesis to protect astronauts’ cognition and mood from decline due to space radiation effects	5
Assessment of Spaceflight Medical Conditions’ and Treatments’ Potential Impacts on Behavioral Health and Performance	5
The Need for Biological Countermeasures to Mitigate the Risk of Space Radiation-Induced Carcinogenesis, Cardiovascular Disease, and Central Nervous System Deficiencies	5
Limb position sense and sensorimotor performance under conditions of weightlessness	5
Subsequent inclusion/exclusion criteria to select the best species for an experiment performed on the ISS in a refurbished hardware	5
Zoster patients on earth and astronauts in space share similar immunologic profiles	4
Effects of stepwise changes in dissolved carbon dioxide concentrations on metabolic activity in Chlorella for spaceflight applications	4
Comparative study of methods for detecting extraterrestrial life in exploration mission of Mars and the solar system	4
Dynamic visual acuity as a biometric for astronaut performance and safety	4
Long-term pharmacological torpor of rats with feedback-controlled drug administration	4
Blood flow in the internal jugular veins during the spaceflight – Is it actually bidirectional?	4
Crew time in a space greenhouse using data from analog missions and Veggie	4
Microarray profile of gene expression in etiolated Pisum sativum seedlings grown under microgravity conditions in space: Relevance to the International Space Station experiment “Auxin Transport”	4
New evidence and insight for abnormalities in early embryonic development after short-term spaceflight onboard the Chinese SJ-10 satellite	4
Looking on the horizon; potential and unique approaches to developing radiation countermeasures for deep space travel	4
Operation overview of a biological waste treatment system during the 4-crew 180-day integrated experiment in the controlled ecological life support system (CELSS)	4
Microbial diversity formation and maintenance due to temporal niche differentiation caused by low-dose ionizing radiation in oligotrophic environments	4
Transfer learning as an AI-based solution to address limited datasets in space medicine	4
Comparison of signaling profiles in the low dose range following low and high LET radiation	4
Comparison of two controlled-release fertilizer formulations for cut-and-come-again harvest yield and mineral content of Lactuca sativa L. cv. Outredgeous grown under International Space Station envir	4
Simulated weightlessness induces cognitive changes in rats illustrated by performance in operant conditioning tasks	4
Medial prefrontal cortex and hippocampus in mice differently affected by simulate microgravity and social isolation associated with the alternation of emotional and cognitive functions	4
Special issue: Planetary protection: New aspects of policy and requirements	3
Angiotensin converting enzyme (ACE) inhibitors as radiation countermeasures for long-duration space flights	3
Optimized crop growth area composition for long duration spaceflight	3
High-throughput screening strategies for space-based radiation countermeasure discovery	3
Investigating alterations in the cellular envelope of Staphylococcus aureus in simulated microgravity using a random positioning machine	3
Effects of low-dose oxygen ions on cardiac function and structure in female C57BL/6J mice	3
Simulated microgravity accelerates aging in Saccharomyces cerevisiae	3
Effects of the geomagnetic field time–varying components compensation as evidenced by heart rate variability of healthy males.	3
Phenotypic and transcriptional changes in Escherichia coli K12 in response to simulated microgravity on the EagleStat, a new 2D microgravity analog for bacterial studies.	3
Mars Terraforming: A Geographic Information Systems Framework	3
Clinical Trial in a Dish for Space Radiation Countermeasure Discovery	3
Mitigation of late cardiovascular effects of oxygen ion radiation by γ-tocotrienol in a mouse model	3
Comparison of the particle flux measured by Liulin-MO dosimeter in ExoMars TGO science orbit with those calculated by models	3
Altered rodent gait characteristics after ~35 days in orbit aboard the International Space Station	3
Baoyuan jieyu formula ameliorates depression-like behaviour in rats induced by simulated long-term spaceflight composite stress through regulating MAPK and BDNF pathways	3
Modeling a lunar base mushroom farm	3
Effects of the Serber first step in 3DHZETRN-v2.1	3
Tunable spectrum resemblance of LED lights for improving the photosynthetic action of Chinese Cabbages	3
Comparison between PHITS and GEANT4 Simulations of the Heavy Ion Beams at the BEVALAC at LBNL and the Booster Accelerator at BNL	3
Bioregenerative life support space diet and nutrition requirements: still seeking accord	3
Observations of neutron radiation environment during Odyssey cruise to Mars	3
The transfer of unsterilized material from Mars to Phobos: Laboratory tests, modelling and statistical evaluation	3
Glycogen metabolism is required for optimal cyanobacterial growth in the rapid light-dark cycle of low-Earth orbit	2
Armed Forces Radiobiology Research Institute/Uniformed Services University of the Health Sciences perspective on space radiation countermeasure discovery	2
Evolving radiological protection guidelines for exploration-class missions	2
Hybrid methods of radiation shielding against deep-space radiation	2
Countermeasure development against space radiation-induced gastrointestinal carcinogenesis: Current and future perspectives	2
Radiation measurements in the International Space Station, Columbus module, in 2020–2022 with the LIDAL detector	2
Solar modulation of the GCR flux and dose rate, observed in space between 1991 and 2019	2
Report of the Joint Workshop on Induced Special Regions	2
Inter-agency perspective: Translating advances in biomarker discovery and medical countermeasures development between terrestrial and space radiation environments	2
Comprehensive analyses of plant hormones in etiolated pea and maize seedlings grown under microgravity conditions in space: Relevance to the International Space Station experiment “Auxin Transport”	2
Synthetic biological circuit tested in spaceflight	2
Development of a NASA roadmap for planetary protection to prepare for the first human missions to Mars	2
Effects of short-term hypergravity on hematopoiesis and vasculogenesis in embryonic zebrafish	2
High throughput screen of small molecules as potential countermeasures to galactic cosmic radiation induced cellular dysfunction	2
Mouse genomic associations with in vitro sensitivity to simulated space radiation	2
Relationship of collagen as the component of the extracellular matrix with the mechanisms of autonomic regulation of the cardiovascular system under simulated conditions of long-term isolation	2
The COSPAR planetary protection requirements for space missions to Venus	2
Planetary protection technologies for planetary science instruments, spacecraft, and missions: Report of the NASA Planetary Protection Technology Definition Team (PPTDT)	2
Nonhuman primate models in the study of spaceflight stressors: Past contributions and future directions	2
Inhibition of SIRT1 by miR-138-5p provides a mechanism for inhibiting osteoblast proliferation and promoting apoptosis under simulated microgravity	2
Microgravity alters the expressions of DNA repair genes and their regulatory miRNAs in space-flown Caenorhabditis elegans	2
Antimicrobial surfaces for use on inhabited space craft: A review	2
Mars sample receiving facility or facilities? That is the question	2
The neurology of space flight; How does space flight effect the human nervous system?	2
Breaking the limit: Biological countermeasures for space radiation exposure to enable long-duration spaceflight	2
Effects of combined exposure to modeled radiation and gravitation factors of the interplanetary flight: Monkeys' cognitive functions and the content of monoamines and their metabolites; cytogenetic ch	2
Extended reality quantification of pupil reactivity as a non-invasive assessment for the pathogenesis of spaceflight associated neuro-ocular syndrome: A technology validation study for astronaut healt	2