OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Orthopaedic Translation is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Epidemiological profiles and intervention strategies of limb deformities in China: A nationwide study based on the largest orthopedic database in China	297
Capability of auxetic femoral stems to reduce stress shielding after total hip arthroplasty	131
From polarity to pathology: Decoding the role of cell orientation in osteoarthritis	131
Near-infrared smart responsive orthopedic implants with synergistic antimicrobial and bone integration-promoting properties	106
Several concerns on grading lumbar disc degeneration on MR image with Pfirrmann criteria	73
Regulation of mitochondrial dynamic equilibrium by physical exercise in sarcopenia: A systematic review	73
Internal fixation with biodegradable high purity magnesium screws in the treatment of ankle fracture	64
Metformin prevents mandibular bone loss in a mouse model of accelerated aging by correcting dysregulated AMPK-mTOR signaling and osteoclast differentiation	64
Treatment of tibial plateau fractures: A comparison of two different operation strategies with medium-term follow up	60
Histone modifications: Unveiling the epigenetic enigma of degenerative skeletal diseases	56
Targeting Piezo1 channel to alleviate intervertebral disc degeneration	56
Clinical and omics biomarkers in osteoarthritis diagnosis and treatment	55
Niobium promotes fracture healing in rats by regulating the PI3K-Akt signalling pathway: An in vivo and in vitro study	55
Revisiting osteoarthritis pathogenesis through the lens of cGAS-STING: Mitochondrial damage, pyroptosis, and inflammatory cascades	54
Biomimicking design of artificial periosteum for promoting bone healing	50
Forkhead box O3 attenuates osteoarthritis by suppressing ferroptosis through inactivation of NF-κB/MAPK signaling	48
Specific microRNAs are associated with fracture healing phases, patient age and multi-trauma	46
Organoids and organs-on-chips for accelerating R&D and clinical translation in Orthopaedics: Emerging opportunities and regulatory pathways	46
Triptolide attenuates inhibition of ankylosing spondylitis-derived mesenchymal stem cells on the osteoclastogenesis through modulating exosomal transfer of circ-0110634	45
2023 January issue Journal of Orthopaedic Translation	43
Addressing musculoskeletal diseases by exploring the potentials of stem cells and plant-derived chemicals	43
RO5126766 attenuates osteoarthritis by inhibiting osteoclastogenesis and protecting chondrocytes through mediating the ERK pathway	42
Comparison of Kindlin-2 deficiency-stimulated osteoarthritis-like lesions induced by Prg4 versus Aggrecan transgene in mice	36
A perspective on reoperations after surgical treatments of degenerative lumbar diseases	36
Does the regulation of skeletal muscle influence cognitive function? A scoping review of pre-clinical evidence	35

Targeting MAT2A synergistically induces DNA damage in osteosarcoma cells through EZH2-mediated H3K27me3 modification	35
Mussel-inspired extracellular matrix-mimicking hydrogel scaffold with high cell affinity and immunomodulation ability for growth factor-free cartilage regeneration	34
Teriparatide ameliorates articular cartilage degradation and aberrant subchondral bone remodeling in DMM mice	34
Exosomes from umbilical cord mesenchymal stem cells ameliorate intervertebral disc degeneration via repairing mitochondrial dysfunction	33
Corrigendum to ‘JD-312 – A novel small molecule that facilitates cartilage repair and alleviates osteoarthritis progression’[Journal of Orthopaedic Translation 44 (2024) 60–71]	32
Advances in experimental models of osteonecrosis of the femoral head	32
Corrigendum to ‘Guideline for adolescent scoliosis screening in China (Public Version 2024)’ [J Orthop Translation, Volume 50, January 2025, Pages 364-372]	31
From scientific discovery to orthopaedic clinical innovation	31
Stress stimulation maintaining by genipin crosslinked hydrogel promotes annulus fibrosus healing	30
Gut-bone axis perturbation: Mechanisms and interventions via gut microbiota as a primary driver of osteoporosis	30
Association between hypertension and osteoarthritis: A systematic review and meta-analysis of observational studies	30
Artificial ligaments in anterior cruciate ligament reconstruction: Coating strategies for PET-based materials	27
Epigenetic reprogramming via EZH2 inhibition rescues fibroadipose pathogenesis in secondary lymphedema through activating PPARγ signaling	27
The novel magnesium–titanium hybrid cannulated screws for the treatment of vertical femoral neck fractures: Biomechanical evaluation	27
Spatially resolved single-cell-based histocytomorphometry for growth plate analysis across multiple species	27
Evaluation of biological performance of 3D printed trabecular porous tantalum spine fusion cage in large animal models	26
Osteocyte β1 integrin loss causes low bone mass and impairs bone mechanotransduction in mice	26
The Revolution of exosomes: From biological functions to therapeutic applications in skeletal muscle diseases	25
Development of a standardized and reproducible murine femoral distraction osteogenesis model	25
Regulating inflammation microenvironment and tenogenic differentiation as sequential therapy promotes tendon healing in diabetic rats	25
Porous metal materials for applications in orthopedic field: A review on mechanisms in bone healing	25
Molecular signaling in temporomandibular joint osteoarthritis	24
Letter to the editor regarding “Promotion of bone-tendon healing after ACL reconstruction using scaffold-free constructs comprising ADSCs produced by a bio-3D printer in rabbit models”	24
Stem cell-based therapeutic strategies for rotator cuff tendinopathy	24
Scoliosis assessment tools to reduce follow-up X-rays	24
Commentary: “Baicalein mediates the anti-tumor activity in Osteosarcoma through lncRNA-NEF driven Wnt/β-catenin signaling regulatory axis”	24
Cerebrospinal fluid-derived extracellular vesicles after spinal cord injury promote vascular regeneration via PI3K/AKT signaling pathway	24
An innovative self-stabilised 3D-printed artificial vertebral body designed for clinical application and comparison with the conventional implants	23
Narirutin mitigates inflammatory arthritis and osteoporosis through modulating macrophage phenotype and osteoclastogenesis	23
Bone microarchitecture assessed by 3D high-resolution peripheral quantitative computed tomography (HR-pQCT) as predictor of fracture risk in patients with glucocorticoid-induced osteoporosis	23
Moderate static magnetic field regulates iron metabolism and salvage bone loss caused by iron accumulation	23
Regenerative strategies for intervertebral disc degeneration	23
Establishment and characterization of an inflammatory cartilaginous organoids model for organoid transplantation study	23
Salivary nitrate prevents osteoporosis via regulating bone marrow mesenchymal stem cells proliferation and differentiation	23
Daily low-intensity pulsed ultrasound stimulation mitigates joint degradation and pain in a post-traumatic osteoarthritis rat model	23
Eurycomanone stimulates bone mineralization in zebrafish larvae and promotes osteogenic differentiation of mesenchymal stem cells by upregulating AKT/GSK-3β/β-catenin signaling	22
Strontium zinc silicate simultaneously alleviates osteoporosis and sarcopenia in tail-suspended rats via Piezo1-mediated Ca2+ signaling	22
Modular de- and re-construction of vascularized osteochondral tissues in an Organ-on-Chip dual-compartment platform	22
The transplantation of particulated juvenile allograft cartilage and synovium for the repair of meniscal defect in a lapine model	21
Melatonin suppresses bone marrow adiposity in ovariectomized rats by rescuing the imbalance between osteogenesis and adipogenesis through SIRT1 activation	21
Tibial cortex transverse transport regulates Orai1/STIM1-mediated NO release and improve the migration and proliferation of vessels via increasing osteopontin expression	21
Establishment of a clinically relevant beagle model for periprosthetic joint infection with 3D-printed prostheses and multimodal evaluation	21
COVID-19 hip fracture outcomes: The role of Ct values and D-dimer levels?	21
Osteoarthritis: A complicated joint disease requiring extensive studies with multiple approaches	21
Mitochondrial Transplantation/Transfer: Promising Therapeutic Strategies for Spinal Cord Injury	21
GPX4 activator enhances neuroprotection and functional recovery in spinal cord injury	21
Combination of cobalt, chromium and titanium nanoparticles increases cytotoxicity in vitro and pro-inflammatory cytokines in vivo	20
Hype or hope of hyaluronic acid for osteoarthritis: Integrated clinical evidence synthesis with multi-organ transcriptomics	20
Gli1 depletion induces oxidative stress and apoptosis of nucleus pulposus cells via Fos in intervertebral disc degeneration	20
PINK1-mediated mitophagy contributes to glucocorticoid-induced cathepsin K production in osteocytes	20

Fibrocartilage hyalinization: A potential therapeutic strategy for articular fibrocartilage	20
The role of Piezo1 in bone marrow stem cells in response to elevated intraosseous pressure on regulating osteogenesis and angiogenesis of steroid-induced osteonecrosis of the femoral head	20
From “academic success” to “commercial success” —The model of medical device translation driven by SCI articles	20
Ubiquitination and deubiquitination: Implications for the pathogenesis and treatment of osteoarthritis	20
Dynamic finite element analyses to compare the influences of customised total talar replacement and total ankle arthroplasty on foot biomechanics during gait	20
Electric currents in disc health: The role of ion channels in intervertebral disc pathophysiology	20
Addressing musculoskeletal disorders through new treatment strategies	20
Relieving oxidative stress microenvironment and promoting vascularized bone formation to treat femoral head necrosis using 3D-printed scaffold with ultralong-term multienzyme-like activity	20
Sustained BMP-2 delivery via alginate microbeads and polydopamine-coated 3D-Printed PCL/β-TCP scaffold enhances bone regeneration in long bone segmental defects	20
Bone marrow-derived myeloid cells drive neuroinflammation in Alzheimer's disease: Insights from the FAD4T mouse model	19
Randomized control trial of mesenchymal stem cells versus hyaluronic acid in patients with knee osteoarthritis – A Hong Kong pilot study	19
Correlations between paraspinal extensor muscle endurance and clinical outcomes in preoperative LSS patients and clinical value of an endurance classification	19
Kindlin-2 deletion in osteoprogenitors causes severe chondrodysplasia and low-turnover osteopenia in mice	19
Role of oxidative stress in mitochondrial dysfunction and their implications in intervertebral disc degeneration: Mechanisms and therapeutic strategies	19
Zhuangyao Jianshen Wan ameliorates senile osteoporosis in SAMP6 mice through Modulation of the GCN5L1-mediated PI3K/Akt/wnt signaling pathway	19
A static magnetic field enhances the repair of osteoarthritic cartilage by promoting the migration of stem cells and chondrogenesis	18
Targeting ANT1 to regulate PINK1/Parkin-mediated mitophagy is an effective treatment of trauma-induced tendon heterotopic ossification	18
Implants coating strategies for antibacterial treatment in fracture and defect models: A systematic review of animal studies	18
Three-dimensional distribution of subchondral fracture lines in osteonecrosis of the femoral head	18
Naringin inhibits the osteoblast-osteoclast pyroptosis cascade reaction mediated by accumulated bone marrow adipose tissue in the treatment of postmenopausal osteoporosis	18
Pyroptosis-related crosstalk in osteoarthritis: Macrophages, fibroblast-like synoviocytes and chondrocytes	17
Dihydroartemisinin ameliorates hemarthrosis-induced cartilage degeneration by suppressing chondrocyte senescence via activation of Keap1-Nrf2 signaling pathway	17
AMPK activator decelerates osteoarthritis development by inhibition of β-catenin signaling in chondrocytes	17
Four-year comparative analysis of return to sport and psychological recovery following ACL revision: Artificial ligament vs. anterior tibial tendon allograft	17
Inhibition of ERK1/2 mediated activation of Drp1 alleviates intervertebral disc degeneration via suppressing pyroptosis and apoptosis in nucleus pulposus cells	17
Risk-stratified lifetime risk and incidence of hip fracture and falls in middle-aged and elderly Chinese population: The China health and retirement longitudinal study	17
Ferroptosis-mediated immune responses in osteoporosis	17
Harnessing the potential of hyaluronic acid methacrylate (HAMA) hydrogel for clinical applications in orthopaedic diseases	16
Evolutionary course of the femoral head osteonecrosis: Histopathological - radiologic characteristics and clinical staging systems	16
Design of internal fixation implants for fracture: A review	16
Bridging basic science and clinical practice in orthopaedic translational research	16
Autologous osteoperiosteal transplantation achieves comparable repair effect and superior interface integration to autologous osteochondral transplantation in porcine osteochondral defects	16
Evaluation of interbody fusion efficacy and biocompatibility of a polyetheretherketone/calcium silicate/porous tantalum cage in a goat model	15
Augmenting osteoporotic osseointegration through a temporal release nanocoating-based reversing dysregulated osteogenic microenvironment	15
T cell related osteoimmunology in fracture healing: Potential targets for augmenting bone regeneration	15
Chronic pain after spine surgery: Insights into pathogenesis, new treatment, and preventive therapy	15
1–2 T static magnetic field combined with Ferumoxytol prevent unloading-induced bone loss by regulating iron metabolism in osteoclastogenesis	15
Stevioside attenuates osteoarthritis via regulating Nrf2/HO-1/NF-κB pathway	15
Redefining orthopaedic translation: Harnessing multi-omics, smart biomaterials, and regenerative immunomodulation	15
SPARCL1 promotes chondrocytes extracellular matrix degradation and inflammation in osteoarthritis via TNF/NF-κB pathway	15
Promotion of bone-tendon healing after ACL reconstruction using scaffold-free constructs comprising ADSCs produced by a bio-3D printer in rabbit models	14
Targeting the GLP-1/GLP-1R axis to treat osteoarthritis: A new opportunity?	14
Corrigendum to ‘N6-methyladenosine and intervertebral disc degeneration: Advances in detection and pathological insights’ [J Orthop Translat 53 (2025) 38–51/JOT 941]	14
Gallic acid mediates tumor-suppressive effects on osteosarcoma through the H19-Wnt/β-catenin regulatory axis	14
The involvement of signaling pathways in the pathogenesis of osteoarthritis: An update	14
Immunoporosis: The hidden link between aging immune cells and bone fragility	14
The effect of local sympatholysis on bone-tendon interface healing in a murine rotator cuff repair model	14
Sargassum polysaccharide attenuates osteoarthritis in rats and is associated with the up-regulation of the ITGβ1-PI3K-AKT signaling pathway	14
Cycloastragenol prevents bone loss via inhibiting osteoclast activity in glucocorticoid-induced osteonecrosis of the femoral head: An in vivo study	14
Irisin reduces bone fracture by facilitating osteogenesis and antagonizing TGF-β/Smad signaling in a growing mouse model of osteogenesis imperfecta	14