Stem Cell Reports

Article	Citations
The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2	133
ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update	133
Naive Human Embryonic Stem Cells Can Give Rise to Cells with a Trophoblast-like Transcriptome and Methylome	131
Adult Hippocampal Neurogenesis in Aging and Alzheimer's Disease	117
Developing human pluripotent stem cell-based cerebral organoids with a controllable microglia ratio for modeling brain development and pathology	108
Modeling and Rescue of RP2 Retinitis Pigmentosa Using iPSC-Derived Retinal Organoids	105
Developing Organoids from Ovarian Cancer as Experimental and Preclinical Models	104
Electrophysiological Maturation of Cerebral Organoids Correlates with Dynamic Morphological and Cellular Development	96
Revealing Tissue-Specific SARS-CoV-2 Infection and Host Responses using Human Stem Cell-Derived Lung and Cerebral Organoids	90
Impairment of Mitochondrial Calcium Buffering Links Mutations in C9ORF72 and TARDBP in iPS-Derived Motor Neurons from Patients with ALS/FTD	85
SARS-CoV-2 targets glial cells in human cortical organoids	70
SARS-CoV-2 Infects Human Pluripotent Stem Cell-Derived Cardiomyocytes, Impairing Electrical and Mechanical Function	69
Human neuronal networks on micro-electrode arrays are a highly robust tool to study disease-specific genotype-phenotype correlations in vitro	65
Extension of retinofugal projections in an assembled model of human pluripotent stem cell-derived organoids	64
LRRK2 Is Recruited to Phagosomes and Co-recruits RAB8 and RAB10 in Human Pluripotent Stem Cell-Derived Macrophages	63
Mesenchymal stromal cell-derived exosomes in cardiac regeneration and repair	60
Erythroid precursors and progenitors suppress adaptive immunity and get invaded by SARS-CoV-2	60
A conversation with ChatGPT on the role of computational systems biology in stem cell research	59
Human embryo research, stem cell-derived embryo models and in vitro gametogenesis: Considerations leading to the revised ISSCR guidelines	59
In Vivo Reprogramming Ameliorates Aging Features in Dentate Gyrus Cells and Improves Memory in Mice	58
Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery	56
NGN2 induces diverse neuron types from human pluripotency	54
Rebooting the Epigenomes during Mammalian Early Embryogenesis	53
Gene Therapy of Dominant CRX-Leber Congenital Amaurosis using Patient Stem Cell-Derived Retinal Organoids	53
APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation	52

Divergent Effects of Dnmt3a and Tet2 Mutations on Hematopoietic Progenitor Cell Fitness	52
Retinal Ganglion Cells With a Glaucoma OPTN(E50K) Mutation Exhibit Neurodegenerative Phenotypes when Derived from Three-Dimensional Retinal Organoids	51
Soft Matrix Promotes Cardiac Reprogramming via Inhibition of YAP/TAZ and Suppression of Fibroblast Signatures	51
Spatiotemporal Analysis Reveals Overlap of Key Proepicardial Markers in the Developing Murine Heart	51
Distinct Phases of Postnatal Skeletal Muscle Growth Govern the Progressive Establishment of Muscle Stem Cell Quiescence	51
Human Erythroid Progenitors Are Directly Infected by SARS-CoV-2: Implications for Emerging Erythropoiesis in Severe COVID-19 Patients	50
Opportunities and challenges with stem cell-based embryo models	50
Human iPSC-Derived Neurons and Cerebral Organoids Establish Differential Effects of Germline NF1 Gene Mutations	49
Basal-like Progenitor Cells: A Review of Dysplastic Alveolar Regeneration and Remodeling in Lung Repair	49
Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies	48
Axonal Extensions along Corticospinal Tracts from Transplanted Human Cerebral Organoids	48
Engineering spatial-organized cardiac organoids for developmental toxicity testing	47
Age-Related Changes in the Inflammatory Status of Human Mesenchymal Stem Cells: Implications for Cell Therapy	47
Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition	46
Defects in Mitochondrial Biogenesis Drive Mitochondrial Alterations in PARKIN-Deficient Human Dopamine Neurons	46
Engineered 3D vessel-on-chip using hiPSC-derived endothelial- and vascular smooth muscle cells	46
A Manually Curated Database on Clinical Studies Involving Cell Products Derived from Human Pluripotent Stem Cells	45
Comparison of 10 Control hPSC Lines for Drug Screening in an Engineered Heart Tissue Format	45
Gastruloids generated without exogenous Wnt activation develop anterior neural tissues	44
Epigenomic and Transcriptomic Changes During Human RPE EMT in a Stem Cell Model of Epiretinal Membrane Pathogenesis and Prevention by Nicotinamide	43
Pro-maturational Effects of Human iPSC-Derived Cortical Astrocytes upon iPSC-Derived Cortical Neurons	43
Identifying Therapeutic Agents for Amelioration of Mitochondrial Clearance Disorder in Neurons of Familial Parkinson Disease	43
The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular research	41
Neurotropic Effects of SARS-CoV-2 Modeled by the Human Brain Organoids	41
Estrogen Receptor β Controls Muscle Growth and Regeneration in Young Female Mice	40
Pharmacologic therapy for engraftment arrhythmia induced by transplantation of human cardiomyocytes	40
Human Intestinal Organoids Recapitulate Enteric Infections of Enterovirus and Coronavirus	39
APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes	39
Disease modeling of pulmonary fibrosis using human pluripotent stem cell-derived alveolar organoids	38
Generation and Differentiation of Adult Tissue-Derived Human Thyroid Organoids	38
Efficient conversion of human induced pluripotent stem cells into microglia by defined transcription factors	38
Gli1+ Cells Couple with Type H Vessels and Are Required for Type H Vessel Formation	38
Neuroinflammation and EIF2 Signaling Persist despite Antiretroviral Treatment in an hiPSC Tri-culture Model of HIV Infection	38
Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection	37
Role of the Internal Limiting Membrane in Structural Engraftment and Topographic Spacing of Transplanted Human Stem Cell-Derived Retinal Ganglion Cells	37
Imaging Transplanted Photoreceptors in Living Nonhuman Primates with Single-Cell Resolution	36
Cardiomyocytes recruit monocytes upon SARS-CoV-2 infection by secreting CCL2	35
Making neurons, made easy: The use of Neurogenin-2 in neuronal differentiation	35
Single-Cell RNA-Seq Reveals that CD9 Is a Negative Marker of Glucose-Responsive Pancreatic β-like Cells Derived from Human Pluripotent Stem Cells	35
Gastruloid Development Competence Discriminates Different States of Pluripotency	35
Regulation and Roles of the Nucleolus in Embryonic Stem Cells: From Ribosome Biogenesis to Genome Organization	35
Generation of Retinal Pigment Epithelial Cells Derived from Human Embryonic Stem Cells Lacking Human Leukocyte Antigen Class I and II	34
Homozygous might be hemizygous: CRISPR/Cas9 editing in iPSCs results in detrimental on-target defects that escape standard quality controls	33
Maturation of Pluripotent Stem Cell-Derived Cardiomyocytes Enables Modeling of Human Hypertrophic Cardiomyopathy	33
Human Mesenchymal Stromal Cells Are Resistant to SARS-CoV-2 Infection under Steady-State, Inflammatory Conditions and in the Presence of SARS-CoV-2-Infected Cells	32
Damaged Myofiber-Derived Metabolic Enzymes Act as Activators of Muscle Satellite Cells	32
Induced Fetal Human Muscle Stem Cells with High Therapeutic Potential in a Mouse Muscular Dystrophy Model	32
Nucleosides Rescue Replication-Mediated Genome Instability of Human Pluripotent Stem Cells	32
Robotic high-throughput biomanufacturing and functional differentiation of human pluripotent stem cells	32
Non-human primates as a model for human development	31

Mitoregulin Controls β-Oxidation in Human and Mouse Adipocytes	30
Human Aging Alters the Spatial Organization between CD34+ Hematopoietic Cells and Adipocytes in Bone Marrow	30
Non-viral Induction of Transgene-free iPSCs from Somatic Fibroblasts of Multiple Mammalian Species	30
Arachidonic Acid Promotes Intestinal Regeneration by Activating WNT Signaling	30
Efficient ssODN-Mediated Targeting by Avoiding Cellular Inhibitory RNAs through Precomplexed CRISPR-Cas9/sgRNA Ribonucleoprotein	28
Surgical Transplantation of Human RPE Stem Cell-Derived RPE Monolayers into Non-Human Primates with Immunosuppression	28
Generation of caudal-type serotonin neurons and hindbrain-fate organoids from hPSCs	28
Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells	28
A Scalable Suspension Platform for Generating High-Density Cultures of Universal Red Blood Cells from Human Induced Pluripotent Stem Cells	28
Derivation of Peripheral Nociceptive, Mechanoreceptive, and Proprioceptive Sensory Neurons from the same Culture of Human Pluripotent Stem Cells	27
Modulation by DREADD reveals the therapeutic effect of human iPSC-derived neuronal activity on functional recovery after spinal cord injury	27
Allele-specific gene editing to rescue dominant CRX-associated LCA7 phenotypes in a retinal organoid model	27
Progress in Modeling and Targeting Inner Ear Disorders with Pluripotent Stem Cells	27
Photobiomodulation therapy for hair regeneration: A synergetic activation of β-CATENIN in hair follicle stem cells by ROS and paracrine WNTs	26
Bioengineering in vitro models of embryonic development	26
WTAP Function in Sertoli Cells Is Essential for Sustaining the Spermatogonial Stem Cell Niche	26
Derivation of functional trophoblast stem cells from primed human pluripotent stem cells	26
Dynamic 3D Chromatin Reorganization during Establishment and Maintenance of Pluripotency	26
Characterization of hiPSC-Derived Muscle Progenitors Reveals Distinctive Markers for Myogenic Cell Purification Toward Cell Therapy	26
Organs-on-chip: The way forward	26
Human stem cell-based retina on chip as new translational model for validation of AAV retinal gene therapy vectors	26
Using Cardiovascular Cells from Human Pluripotent Stem Cells for COVID-19 Research: Why the Heart Fails	26
Mthfd2 Modulates Mitochondrial Function and DNA Repair to Maintain the Pluripotency of Mouse Stem Cells	26
Identification of bioactive metabolites in human iPSC-derived dopaminergic neurons with PARK2 mutation: Altered mitochondrial and energy metabolism	25
FGFR3 in Periosteal Cells Drives Cartilage-to-Bone Transformation in Bone Repair	25
Iron accumulation induces oxidative stress, while depressing inflammatory polarization in human iPSC-derived microglia	25
Aging of intestinal stem cells	25
Antitumor effects of iPSC-based cancer vaccine in pancreatic cancer	25
Human induced pluripotent stem cell-derived atrial cardiomyocytes carrying an SCN5A mutation identify nitric oxide signaling as a mediator of atrial fibrillation	24
A functional hiPSC-cortical neuron differentiation and maturation model and its application to neurological disorders	24
Apoptosis, G1 Phase Stall, and Premature Differentiation Account for Low Chimeric Competence of Human and Rhesus Monkey Naive Pluripotent Stem Cells	24
Androgen Maintains Intestinal Homeostasis by Inhibiting BMP Signaling via Intestinal Stromal Cells	24
Isogenic Sets of hiPSC-CMs Harboring Distinct KCNH2 Mutations Differ Functionally and in Susceptibility to Drug-Induced Arrhythmias	24
All models are wrong, but some are useful: Establishing standards for stem cell-based embryo models	24
Engineered models of the human heart: Directions and challenges	24
CRISPR/Cas9/AAV9-mediated in vivo editing identifies MYC regulation of 3D genome in skeletal muscle stem cell	24
Differentiation of human induced pluripotent stem cells to authentic macrophages using a defined, serum-free, open-source medium	24
Increased Expression of Interleukin-1 Receptor Characterizes Anti-estrogen-Resistant ALDH+ Breast Cancer Stem Cells	23
Cell-Surface Proteomics Identifies Differences in Signaling and Adhesion Protein Expression between Naive and Primed Human Pluripotent Stem Cells	23
Patients' perspectives on the derivation and use of organoids	23
Microglia-Secreted Factors Enhance Dopaminergic Differentiation of Tissue- and iPSC-Derived Human Neural Stem Cells	23
Unproven stem cell interventions: A global public health problem requiring global deliberation	23
Developmental Stage-Specific Changes in Protein Synthesis Differentially Sensitize Hematopoietic Stem Cells and Erythroid Progenitors to Impaired Ribosome Biogenesis	23
Astrocytic reactivity triggered by defective autophagy and metabolic failure causes neurotoxicity in frontotemporal dementia type 3	23
Increased tissue stiffness triggers contractile dysfunction and telomere shortening in dystrophic cardiomyocytes	23
Whole-genome CRISPR screening identifies genetic manipulations to reduce immune rejection of stem cell-derived islets	22
UTX Regulates Human Neural Differentiation and Dendritic Morphology by Resolving Bivalent Promoters	22
An In Vitro Differentiation Protocol for Human Embryonic Bipotential Gonad and Testis Cell Development	22
Canonical Wnt Pathway Controls mESC Self-Renewal Through Inhibition of Spontaneous Differentiation via β-Catenin/TCF/LEF Functions	22
Efficient generation of dopaminergic induced neuronal cells with midbrain characteristics	22
A human pluripotent stem cell-based model of SARS-CoV-2 infection reveals an ACE2-independent inflammatory activation of vascular endothelial cells through TLR4	22
Novel Lineage-Tracing System to Identify Site-Specific Ectopic Bone Precursor Cells	21
SARS-CoV-2 infects and replicates in photoreceptor and retinal ganglion cells of human retinal organoids	21
Megakaryocyte progenitor cell function is enhanced upon aging despite the functional decline of aged hematopoietic stem cells	21
Restoration of hippocampal neural precursor function by ablation of senescent cells in the aging stem cell niche	21
Biomanufacturing in low Earth orbit for regenerative medicine	21
Stem Cell-Derived Human Striatal Progenitors Innervate Striatal Targets and Alleviate Sensorimotor Deficit in a Rat Model of Huntington Disease	21
Modulating adult neurogenesis affects synaptic plasticity and cognitive functions in mouse models of Alzheimer's disease	21
A Single Radioprotective Dose of Prostaglandin E2 Blocks Irradiation-Induced Apoptotic Signaling and Early Cycling of Hematopoietic Stem Cells	21
Inhibition of Apoptosis Reduces Diploidization of Haploid Mouse Embryonic Stem Cells during Differentiation	21
Development of a scalable method to isolate subsets of stem cell-derived pancreatic islet cells	21
Comparative Analysis of Patient-Matched PDOs Revealed a Reduction in OLFM4-Associated Clusters in Metastatic Lesions in Colorectal Cancer	21
Novel synthetic biology approaches for developmental systems	21
Conserved features of non-primate bilaminar disc embryos and the germline	21
Survival of an HLA-mismatched, bioengineered RPE implant in dry age-related macular degeneration	21
Molecular Mechanisms Underlying Ascl1-Mediated Astrocyte-to-Neuron Conversion	21
Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone	20
Pluripotent stem cell derived dopaminergic subpopulations model the selective neuron degeneration in Parkinson’s disease	20
Gene expression dynamics underlying cell fate emergence in 2D micropatterned human embryonic stem cell gastruloids	20
Pluripotent stem cell–derived corneal endothelial cells as an alternative to donor corneal endothelium in keratoplasty	20
The Snakeskin-Mesh Complex of Smooth Septate Junction Restricts Yorkie to Regulate Intestinal Homeostasis in Drosophila	20
Differentiation of brain and retinal organoids from confluent cultures of pluripotent stem cells connected by nerve-like axonal projections of optic origin	20
ISSCR guidelines for the transfer of human pluripotent stem cells and their direct derivatives into animal hosts	20
Balancing serendipity and reproducibility: Pluripotent stem cells as experimental systems for intellectual and developmental disorders	20
Genomic Safe Harbor Expression of PAX7 for the Generation of Engraftable Myogenic Progenitors	20
Survey Says: “COVID-19 Lockdown Hits Young Faculty and Clinical Trials”	20
GATA6-AS1 Regulates GATA6 Expression to Modulate Human Endoderm Differentiation	20
Human Pluripotent Stem Cell-Derived Intestinal Organoids Model SARS-CoV-2 Infection Revealing a Common Epithelial Inflammatory Response	20
Assessing donor-to-donor variability in human intestinal organoid cultures	20
Altered Neuronal Support and Inflammatory Response in Bipolar Disorder Patient-Derived Astrocytes	20

Transplantation of Skin Precursor-Derived Schwann Cells Yields Better Locomotor Outcomes and Reduces Bladder Pathology in Rats with Chronic Spinal Cord Injury	20
Insulin Promotes Mitochondrial Respiration and Survival through PI3K/AKT/GSK3 Pathway in Human Embryonic Stem Cells	20
Age-related pathological impairments in directly reprogrammed dopaminergic neurons derived from patients with idiopathic Parkinson’s disease	20
One-step Reprogramming of Human Fibroblasts into Oligodendrocyte-like Cells by SOX10, OLIG2, and NKX6.2	19
A new platform for high-throughput therapy testing on iPSC-derived lung progenitor cells from cystic fibrosis patients	19
Reprogramming astrocytes to motor neurons by activation of endogenous Ngn2 and Isl1	19
Mammalian Germ Cell Development: From Mechanism to In Vitro Reconstitution	19
Low Immunogenicity and Immunosuppressive Properties of Human ESC- and iPSC-Derived Retinas	19
EBiSC best practice: How to ensure optimal generation, qualification, and distribution of iPSC lines	19
MFN2 Plays a Distinct Role from MFN1 in Regulating Spermatogonial Differentiation	19
Two Functional Axes of Feedback-Enforced PRC2 Recruitment in Mouse Embryonic Stem Cells	19
The Organoid Platform: Promises and Challenges as Tools in the Fight against COVID-19	19
GP2-enriched pancreatic progenitors give rise to functional beta cells in vivo and eliminate the risk of teratoma formation	19
Direct Comparison of Four Hematopoietic Differentiation Methods from Human Induced Pluripotent Stem Cells	18
Broad-Spectrum Anti-coronavirus Vaccines and Therapeutics to Combat the Current COVID-19 Pandemic and Future Coronavirus Disease Outbreaks	18
Retinoic Acid Accelerates the Specification of Enteric Neural Progenitors from In-Vitro-Derived Neural Crest	18
Machine learning-assisted high-content analysis of pluripotent stem cell-derived embryos in vitro	18
The role of SQSTM1 (p62) in mitochondrial function and clearance in human cortical neurons	18
YAP Non-cell-autonomously Promotes Pluripotency Induction in Mouse Cells	18
Unique Patterns of H3K4me3 and H3K27me3 in 2-Cell-like Embryonic Stem Cells	18
Direct Reprogramming of Human Fetal- and Stem Cell-Derived Glial Progenitor Cells into Midbrain Dopaminergic Neurons	18
Generation of Human-Induced Pluripotent Stem Cell-Derived Functional Enterocyte-Like Cells for Pharmacokinetic Studies	18
Sestrins regulate muscle stem cell metabolic homeostasis	18
Hippocampal Neurogenesis Requires Cell-Autonomous Thyroid Hormone Signaling	18
Modeling reduced contractility and impaired desmosome assembly due to plakophilin-2 deficiency using isogenic iPS cell-derived cardiomyocytes	18
Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage	18
In Vitro Differentiated Human Stem Cell-Derived Neurons Reproduce Synaptic Synchronicity Arising during Neurodevelopment	17
Functional genomics and the future of iPSCs in disease modeling	17
A Highly Phenotyped Open Access Repository of Alpha-1 Antitrypsin Deficiency Pluripotent Stem Cells	17
Human iPSC model reveals a central role for NOX4 and oxidative stress in Duchenne cardiomyopathy	17
The Median Eminence, A New Oligodendrogenic Niche in the Adult Mouse Brain	17
Physiological calcium combined with electrical pacing accelerates maturation of human engineered heart tissue	17
Histone Modifications in Stem Cell Development and Their Clinical Implications	17
Chromatin-Associated Membraneless Organelles in Regulation of Cellular Differentiation	17
Generation of pancreatic progenitors from human pluripotent stem cells by small molecules	17
In Vitro Meiosis of Male Germline Stem Cells	17
YAP1 regulates the self-organized fate patterning of hESC-derived gastruloids	17
Human primed and naïve PSCs are both able to differentiate into trophoblast stem cells	17
Deep neural net tracking of human pluripotent stem cells reveals intrinsic behaviors directing morphogenesis	17
Human Stem Cell Resources Are an Inroad to Neandertal DNA Functions	17
Quick Commitment and Efficient Reprogramming Route of Direct Induction of Retinal Ganglion Cell-like Neurons	16
Entropy sorting of single-cell RNA sequencing data reveals the inner cell mass in the human pre-implantation embryo	16
Human tau mutations in cerebral organoids induce a progressive dyshomeostasis of cholesterol	16
Primary Ciliary Deficits in the Dentate Gyrus of Fragile X Syndrome	16
Directly induced human retinal ganglion cells mimic fetal RGCs and are neuroprotective after transplantation in vivo	16
The chromatin accessibility landscape reveals distinct transcriptional regulation in the induction of human primordial germ cell-like cells from pluripotent stem cells	16
The Periostin/Integrin-αv Axis Regulates the Size of Hematopoietic Stem Cell Pool in the Fetal Liver	16
Spermatogonial stem cell transplantation into nonablated mouse recipient testes	16
A CX3CR1 Reporter hESC Line Facilitates Integrative Analysis of In-Vitro-Derived Microglia and Improved Microglia Identity upon Neuron-Glia Co-culture	16
Systemic immunosuppression promotes survival and integration of subretinally implanted human ESC-derived photoreceptor precursors in dogs	16
Rapid Crypt Cell Remodeling Regenerates the Intestinal Stem Cell Niche after Notch Inhibition	16
Splicing Factor SRSF1 Is Essential for Satellite Cell Proliferation and Postnatal Maturation of Neuromuscular Junctions in Mice	16
Sleep deprivation induces corneal epithelial progenitor cell over-expansion through disruption of redox homeostasis in the tear film	16
Development of human iPSC-derived quiescent hepatic stellate cell-like cells for drug discovery and in vitro disease modeling	16
Apple Peel and Flesh Contain Pro-neurogenic Compounds	16
Myogenic Progenitor Cell Lineage Specification by CRISPR/Cas9-Based Transcriptional Activators	16
Single-Cell Analysis Reveals Partial Reactivation of X Chromosome instead of Chromosome-wide Dampening in Naive Human Pluripotent Stem Cells	16
Cell-to-Cell Adhesion and Neurogenesis in Human Cortical Development: A Study Comparing 2D Monolayers with 3D Organoid Cultures	16
Hedgehog Activation Regulates Human Osteoblastogenesis	16