Stem Cell Reports

Article	Citations
Genome-wide analyses reveal the detrimental impacts of SARS-CoV-2 viral gene Orf9c on human pluripotent stem cell-derived cardiomyocytes	199
Expanding homogeneous culture of human primordial germ cell-like cells maintaining germline features without serum or feeder layers	190
A regulatory role for CHD4 in maintenance of the spermatogonial stem cell pool	158
Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies	96
Reconstruction of dynamic regulatory networks reveals signaling-induced topology changes associated with germ layer specification	96
Putting Science into Standards workshop on standards for organ-on-chip	92
Deriving waveform parameters from calcium transients in human iPSC-derived cardiomyocytes to predict cardiac activity with machine learning	91
Effect of Notch1 signaling on muscle engraftment and maturation from pluripotent stem cells	84
Improved hematopoietic stem cell transplantation upon inhibition of natural killer cell-derived interferon-gamma	83
A versatile in vivo platform for reversible control of transgene expression in adult tissues	81
Patients' perspectives on the derivation and use of organoids	79
Silencing of p53 and CDKN1A establishes sustainable immortalized megakaryocyte progenitor cells from human iPSCs	78
MSCohi-O lenses for long-term retention of mesenchymal stem cells on ocular surface as a therapeutic approach for chronic ocular graft-versus-host disease	73
Erythroid precursors and progenitors suppress adaptive immunity and get invaded by SARS-CoV-2	69
YAP signaling in horizontal basal cells promotes the regeneration of olfactory epithelium after injury	67
Dissecting the impact of differentiation stage, replicative history, and cell type composition on epigenetic clocks	66
Human iPSC-based neurodevelopmental models of globoid cell leukodystrophy uncover patient- and cell type-specific disease phenotypes	65
Ribosomal proteins regulate 2-cell-stage transcriptome in mouse embryonic stem cells	64
Familial Alzheimer’s disease-associated PSEN1 mutations affect neurodevelopment through increased Notch signaling	55
USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development	55
Insertion/deletion and microsatellite alteration profiles in induced pluripotent stem cells	54
In and out: Benchmarking in vitro, in vivo, ex vivo, and xenografting approaches for an integrative brain disease modeling pipeline	54
Connie Eaves (1944–2024)	50
Bone morphogenetic protein 4 induces hematopoietic stem cell development from murine hemogenic endothelial cells in culture	50
Single-cell transcriptomics reveals correct developmental dynamics and high-quality midbrain cell types by improved hESC differentiation	49

Human spinal GABA neurons survive and mature in the injured nonhuman primate spinal cord	48
Gains of 20q11.21 in human pluripotent stem cells: Insights from cancer research	48
ISSCR’s Guidelines for Stem Cell Research and Clinical Translation: Supporting development of safe and efficacious stem cell-based interventions	46
Differentiation success of reprogrammed cells is heterogeneous in vivo and modulated by somatic cell identity memory	46
Single-cell characterization of neovascularization using hiPSC-derived endothelial cells in a 3D microenvironment	45
DOT1L regulates lung developmental epithelial cell fate and adult alveolar stem cell differentiation after acute injury	45
H1FOO-DD promotes efficiency and uniformity in reprogramming to naive pluripotency	44
Single-cell approaches define two groups of mammalian oligodendrocyte precursor cells and their evolution over developmental time	44
Upregulation of the JAK-STAT pathway promotes maturation of human embryonic stem cell-derived cardiomyocytes	42
IL-18R-mediated HSC quiescence and MLKL-dependent cell death limit hematopoiesis during infection-induced shock	41
Complex haploinsufficiency in pluripotent cells yields somatic cells with DNA methylation abnormalities and pluripotency induction defects	41
Differentiation of human induced pluripotent stem cells to authentic macrophages using a defined, serum-free, open-source medium	40
Functionally redundant roles of ID family proteins in spermatogonial stem cells	40
Plasticity of ocular surface epithelia: Using a murine model of limbal stem cell deficiency to delineate metaplasia and transdifferentiation	39
Sequential regulation of hemogenic fate and hematopoietic stem and progenitor cell formation from arterial endothelium by Ezh1/2	39
GP2-enriched pancreatic progenitors give rise to functional beta cells in vivo and eliminate the risk of teratoma formation	38
Stabilization of cell-cell adhesions prevents symmetry breaking and locks in pluripotency in 3D gastruloids	37
DPPA2, DPPA4, and other DPPA factor epigenomic functions in cell fate and cancer	36
Generation of highly pure pluripotent stem cell-derived myogenic progenitor cells and myotubes	36
Human fetal tissue is critical for biomedical research	36
Public perceptions and expectations: Disentangling the hope and hype of organoid research	35
Engineered models of the human heart: Directions and challenges	35
Mechanical force-promoted osteoclastic differentiation via periodontal ligament stem cell exosomal protein ANXA3	35
Human neuronal networks on micro-electrode arrays are a highly robust tool to study disease-specific genotype-phenotype correlations in vitro	34
What does “appropriate scientific justification” mean for the review of human pluripotent stem cell, embryo, and related research?	34
Glutamine boosts intestinal stem cell-mediated small intestinal epithelial development during early weaning: Involvement of WNT signaling	34
Lessons learnt, and still to learn, in first in human stem cell trials	34
Gene reactivation upon erosion of X chromosome inactivation in female hiPSCs is predictable yet variable and persists through differentiation	34
Spermatogonial stem cell transplantation into nonablated mouse recipient testes	33
UHRF1 interacts with snRNAs and regulates alternative splicing in mouse spermatogonial stem cells	33
Disease modeling of pulmonary fibrosis using human pluripotent stem cell-derived alveolar organoids	33
Medium acidosis drives cardiac differentiation during mesendoderm cell fate specification from human pluripotent stem cells	33
MEF2C/p300-mediated epigenetic remodeling promotes the maturation of induced cardiomyocytes	33
BRD9-containing non-canonical BAF complex maintains somatic cell transcriptome and acts as a barrier to human reprogramming	33
Human iPSC model reveals a central role for NOX4 and oxidative stress in Duchenne cardiomyopathy	32
Epithelial-derived factors induce muscularis mucosa of human induced pluripotent stem cell-derived gastric organoids	32
Response to: SARS-CoV-2 and type I interferon signaling in brain endothelial cells: Blurring the lines between friend or foe	32
Searching for information about stem cells online in an age of artificial intelligence: How should the stem cell community respond?	32
Neutrophils as regulators of macrophage-induced inflammation in a setting of allogeneic bone marrow transplantation	31
DOT1L inhibition enhances pluripotency beyond acquisition of epithelial identity and without immediate suppression of the somatic transcriptome	31
Depletion of WFS1 compromises mitochondrial function in hiPSC-derived neuronal models of Wolfram syndrome	31
Upregulation of β-catenin due to loss of miR-139 contributes to motor neuron death in amyotrophic lateral sclerosis	31
Human pluripotent stem cell-derived eosinophils reveal potent cytotoxicity against solid tumors	31
Ethics and regulatory considerations for the clinical translation of somatic cell human epigenetic editing	31
A single cell-based computational platform to identify chemical compounds targeting desired sets of transcription factors for cellular conversion	30
In vitro expanded skeletal myogenic progenitors from pluripotent stem cell-derived teratomas have high engraftment capacity	30
Early reactivation of clustered genes on the inactive X chromosome during somatic cell reprogramming	30
Transplantation of human pluripotent stem cell-derived retinal sheet in a primate model of macular hole	30
Inhibition of BMP signaling with LDN 193189 can influence bone marrow stromal cell fate but does not prevent hypertrophy during chondrogenesis	30
Non-canonical roles of CFH in retinal pigment epithelial cells revealed by dysfunctional rare CFH variants	30

Regeneration of spermatogenesis by mouse germ cell transplantation into allogeneic and xenogeneic testis primordia or organoids	28
CD49b identifies functionally and epigenetically distinct subsets of lineage-biased hematopoietic stem cells	28
Low fucosylation defines the glycocalyx of progenitor cells and melanocytes in the human limbal stem cell niche	28
Metabolic remodeling in hiPSC-derived myofibers carrying the m.3243A>G mutation	28
Astrocytes modulate neurodegenerative phenotypes associated with glaucoma in OPTN(E50K) human stem cell-derived retinal ganglion cells	28
Parallel use of human stem cell lung and heart models provide insights for SARS-CoV-2 treatment	27
DeePhys: A machine learning–assisted platform for electrophysiological phenotyping of human neuronal networks	27
Granulin loss of function in human mature brain organoids implicates astrocytes in TDP-43 pathology	27
Molecular profiling of stem cell-derived retinal pigment epithelial cell differentiation established for clinical translation	27
Aggregation of cryopreserved mid-hindgut endoderm for more reliable and reproducible hPSC-derived small intestinal organoid generation	26
Induction of astrocyte reactivity promotes neurodegeneration in human pluripotent stem cell models	26
Interspecies chimerism with human embryonic stem cells generates functional human dopamine neurons at low efficiency	26
AAV-mediated gene augmentation therapy of CRB1 patient-derived retinal organoids restores the histological and transcriptional retinal phenotype	26
Involvement of LIN28A in Wnt-dependent regulation of hippocampal neurogenesis in the aging brain	26
Prosaposin maintains adult neural stem cells in a state associated with deep quiescence	26
Patient-specific and gene-corrected induced pluripotent stem cell-derived endothelial cells elucidate single-cell phenotype of pulmonary veno-occlusive disease	26
Titin-truncating variants in hiPSC cardiomyocytes induce pathogenic proteinopathy and sarcomere defects with preserved core contractile machinery	26
Matthias Lutolf, interviewed by Peter Loskill (Vice-Chair of EUROoC, the European-Organ-on-Chip-Society)	26
Mowat-Wilson syndrome factor ZEB2 controls early formation of human neural crest through BMP signaling modulation	26
Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes	25
ISSCR guidelines for the transfer of human pluripotent stem cells and their direct derivatives into animal hosts	25
The trophectoderm acts as a niche for the inner cell mass through C/EBPα-regulated IL-6 signaling	25
Modeling sex differences in humans using isogenic induced pluripotent stem cells	25
Modeling reduced contractility and impaired desmosome assembly due to plakophilin-2 deficiency using isogenic iPS cell-derived cardiomyocytes	25
Generation of canine induced pluripotent stem cells under feeder-free conditions using Sendai virus vector encoding six canine reprogramming factors	25
Astrocytic reactivity triggered by defective autophagy and metabolic failure causes neurotoxicity in frontotemporal dementia type 3	25
Derivation of functional trophoblast stem cells from primed human pluripotent stem cells	24
Taking the leap toward human-specific nonanimal methodologies: The need for harmonizing global policies for microphysiological systems	24
Embryonic stem cell ERK, AKT, plus STAT3 response dynamics combinatorics are heterogeneous but NANOG state independent	23
Ribosome biogenesis controls cranial suture MSC fate via the complement pathway in mouse and human iPSC models	23
Fractalkine enhances oligodendrocyte regeneration and remyelination in a demyelination mouse model	23
Reconstituted ovaries self-assemble without an ovarian surface epithelium	23
Fibroblast fate determination during cardiac reprogramming by remodeling of actin filaments	23
Critical considerations for public engagement in stem cell-related research	23
Small-molecule inhibitor cocktail promotes the proliferation of pre-existing liver progenitor cells	23
Deep-supercooling preservation of stem cell spheroids for chondral defect repairment	23
Businesses marketing purported stem cell treatments and exosome therapies for COVID-19: An analysis of direct-to-consumer online advertising claims	22
Identification of glioblastoma stem cell-associated lncRNAs using single-cell RNA sequencing datasets	22
Aberrant nucleosome organization in mouse SCNT embryos revealed by ULI-MNase-seq	22
Dual inhibition of MAPK and PI3K/AKT pathways enhances maturation of human iPSC-derived cardiomyocytes	22
Micro-patterned culture of iPSC-derived alveolar and airway cells distinguishes SARS-CoV-2 variants	22
A year of engagement and growth: ISSCR’s year-end message from the president 2022–2023	22
Scalable generation of sensory neurons from human pluripotent stem cells	22
CD62L expression level determines the cell fate of myeloid progenitors	22
Rostrocaudal patterning and neural crest differentiation of human pre-neural spinal cord progenitors in vitro	22
The Wnt-dependent master regulator NKX1-2 controls mouse pre-implantation development	22
Human primed and naïve PSCs are both able to differentiate into trophoblast stem cells	21
Prolonged generation of multi-lineage blood cells in wild-type animals from pluripotent stem cells	21
Astrocytes originated from neural stem cells drive the regenerative remodeling of pathologic CSPGs in spinal cord injury	21
Perinuclear mitochondrial clustering for mesenchymal-to-epithelial transition in pluripotency induction	21
MIXL1 activation in endoderm differentiation of human induced pluripotent stem cells	21
A BMP4-p38 MAPK signaling axis controls ISL1 protein stability and activity during cardiogenesis	21
LOTUS overexpression via ex vivo gene transduction further promotes recovery of motor function following human iPSC-NS/PC transplantation for contusive spinal cord injury	21
Defining the nature of human pluripotent stem cell-derived interneurons via single-cell analysis	21
DDX41 is needed for pre- and postnatal hematopoietic stem cell differentiation in mice	21
Uncoupling key determinants of hematopoietic stem cell engraftment through cell-specific and temporally controlled recipient conditioning	21
Reprogramming epiblast stem cells into pre-implantation blastocyst cell-like cells	20
Argonaute proteins regulate a specific network of genes through KLF4 in mouse embryonic stem cells	20
The relevance of mitochondrial DNA variants fluctuation during reprogramming and neuronal differentiation of human iPSCs	20
MAC-1 marks a quiescent and functionally superior HSC subset during regeneration	20
Inducing human retinal pigment epithelium-like cells from somatic tissue	20
Generation, genomic characterization, and differentiation of triploid human embryonic stem cells	20
Human iPSC-derived neural progenitor cells secreting GDNF provide protection in rodent models of ALS and retinal degeneration	20
Increased tissue stiffness triggers contractile dysfunction and telomere shortening in dystrophic cardiomyocytes	19
Cell-autonomous and non-cell-autonomous roles of NKCC1 in regulating neural stem cell quiescence in the hippocampal dentate gyrus	19
Purification of human iPSC-derived cells at large scale using microRNA switch and magnetic-activated cell sorting	19
Selective elimination of pluripotent stem cells by PIKfyve specific inhibitors	19
Differentiation of brain and retinal organoids from confluent cultures of pluripotent stem cells connected by nerve-like axonal projections of optic origin	19
Long noncoding RNA Lnc530 localizes on R-loops and regulates R-loop formation and genomic stability in mouse embryonic stem cells	19
RYBP modulates embryonic neurogenesis involving the Notch signaling pathway in a PRC1-independent pattern	19
The global downregulation of protein synthesis observed during hepatogenic maturation is associated with a decrease in TOP mRNA translation	19
ER stress and lipid imbalance drive diabetic embryonic cardiomyopathy in an organoid model of human heart development	19
Zika virus induces FOXG1 nuclear displacement and downregulation in human neural progenitors	19
Chitinase-like protein 3: A novel niche factor for mouse neural stem cells	19
Human microglial cells as a therapeutic target in a neurodevelopmental disease model	19
Auxin-degron system identifies immediate mechanisms of OCT4	18
Pluripotent cell states and unexpected fates	18
A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells	18
Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes	18
Accelerated mitochondrial dynamics promote spermatogonial differentiation	18

An efficient, non-viral arrayed CRISPR screening platform for iPSC-derived myeloid and microglia models	18
Survival of an HLA-mismatched, bioengineered RPE implant in dry age-related macular degeneration	18
Reprogramming astrocytes to motor neurons by activation of endogenous Ngn2 and Isl1	18
Neuroblast migration along cellular substrates in the developing porcine brain	18
SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants	18
ERRγ agonist under mechanical stretching manifests hypertrophic cardiomyopathy phenotypes of engineered cardiac tissue through maturation	18
Oligodendrocytes in human induced pluripotent stem cell-derived cortical grafts remyelinate adult rat and human cortical neurons	18
Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells	18
A Chemically Defined Feeder-free System for the Establishment and Maintenance of the Human Naive Pluripotent State	18
Defective autophagy and increased apoptosis contribute toward the pathogenesis of FKRP-associated muscular dystrophies	18
Rescuing human fetal tissue research in the United States: A call for additional regulatory reform	18
Subventricular zone adult mouse neural stem cells require insulin receptor for self-renewal	18
Seamless and non-destructive monitoring of extracellular microRNAs during cardiac differentiation from human pluripotent stem cells	18
Interleukin-1β induces trained innate immunity in human hematopoietic progenitor cells in vitro	18
Patient-derived parathyroid organoids as a tracer and drug-screening application model	18
Self-assembling 3D vessel-on-chip model with hiPSC-derived astrocytes	18
Derivation of transplantable human thyroid follicular epithelial cells from induced pluripotent stem cells	18
Spatial transcriptomics reveals molecular cues underlying the site specificity of the adult mouse oral mucosa and its stem cell niches	18
Genetic variation modulates susceptibility to aberrant DNA hypomethylation and imprint deregulation in naive pluripotent stem cells	17
Safe CNV removal is crucial for successful hESC-RPE transplantation in wet age-related macular degeneration	17
Cell size regulates human endoderm specification through actomyosin-dependent AMOT-YAP signaling	17
PI3Kβ-regulated β-catenin mediates EZH2 removal from promoters controlling primed human ESC stemness and primitive streak gene expression	17
Swift induction of human spinal lower motor neurons and robust ALS cell screening via single-cell imaging	17
PBX1-directed stem cell transcriptional program drives tumor progression in myeloproliferative neoplasm	17
A critical role of retinoic acid concentration for the induction of a fully human-like atrial action potential phenotype in hiPSC-CM	17
SnapShot: Reporting practices for publishing results with human PSCs and tissue stem cells	17
Pluripotent stem cell–derived corneal endothelial cells as an alternative to donor corneal endothelium in keratoplasty	17
DOT1L interaction partner AF10 controls patterning of H3K79 methylation and RNA polymerase II to maintain cell identity	17
Cell position within human pluripotent stem cell colonies determines apical specialization via an actin cytoskeleton-based mechanism	17
SALL3 mediates the loss of neuroectodermal differentiation potential in human embryonic stem cells with chromosome 18q loss	17
Sleep deprivation induces corneal epithelial progenitor cell over-expansion through disruption of redox homeostasis in the tear film	17
AT7867 promotes pancreatic progenitor differentiation of human iPSCs	16
The urgent need for clear and concise regulations on exosome-based interventions	16
Generation of a TPH2-EGFP reporter cell line for purification and monitoring of human serotonin neurons in vitro and in vivo	16
Human iPSC-derived photoreceptor transplantation in the cone dominant 13-lined ground squirrel	16
Transcription factor co-expression mediates lineage priming for embryonic and extra-embryonic differentiation	16
Unraveling the impact of ZZZ3 on the mTOR/ribosome pathway in human embryonic stem cells homeostasis	16
Screening of factors inducing alveolar type 1 epithelial cells using human pluripotent stem cells	16