Stem Cell Reports

Article	Citations
Astrocyte-derived PTN alleviates deficits in hippocampal neurogenesis and cognition in models of multiple sclerosis	193
A versatile in vivo platform for reversible control of transgene expression in adult tissues	192
Capture primed pluripotency in guinea pig	185
Investigating the feasibility and ethical implications of phenotypic screening using stem cell-derived tissue models to detect and manage disease	157
Troy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification	90
Robust generation of photoreceptor-dominant retinal organoids from porcine induced pluripotent stem cells	89
Salt-inducible kinases transduce mechanical forces into the specification of the pancreatic endocrine lineage	88
100 plus years of stem cell research—20 years of ISSCR	87
Donor perspectives on informed consent and use of biospecimens for brain organoid research	80
YAP signaling in horizontal basal cells promotes the regeneration of olfactory epithelium after injury	79
Cell transplantation-based regenerative medicine in liver diseases	78
Fractalkine signaling regulates oligodendroglial cell genesis from SVZ precursor cells	77
Competency of iPSC-derived retinas in MHC-mismatched transplantation in non-human primates	75
Deriving waveform parameters from calcium transients in human iPSC-derived cardiomyocytes to predict cardiac activity with machine learning	67
MAC-1 marks a quiescent and functionally superior HSC subset during regeneration	67
DDX41 is needed for pre- and postnatal hematopoietic stem cell differentiation in mice	66
Transparency in controversial research: A review of human embryo research publication ethical disclosure statements	65
USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development	64
Zika virus induces FOXG1 nuclear displacement and downregulation in human neural progenitors	63
Characterization of perivascular alveolar epithelial stem cells and their niche in lung homeostasis and cancer	54
ERK5 promotes autocrine expression to sustain mitogenic balance for cell fate specification in human pluripotent stem cells	53
Astrocytes originated from neural stem cells drive the regenerative remodeling of pathologic CSPGs in spinal cord injury	52
Automatic identification of small molecules that promote cell conversion and reprogramming	51
Reconciling Flux Experiments for Quantitative Modeling of Normal and Malignant Hematopoietic Stem/Progenitor Dynamics	51
Modulation of APLNR Signaling Is Required during the Development and Maintenance of the Hematopoietic System	48

A regulatory role for CHD4 in maintenance of the spermatogonial stem cell pool	48
From embryos to embryoids: How external signals and self-organization drive embryonic development	46
Reprogramming epiblast stem cells into pre-implantation blastocyst cell-like cells	45
A BMP4-p38 MAPK signaling axis controls ISL1 protein stability and activity during cardiogenesis	44
Uncoupling key determinants of hematopoietic stem cell engraftment through cell-specific and temporally controlled recipient conditioning	44
Reflection on the enactment and impact of safety laws for regenerative medicine in Japan	44
Lesch-Nyhan disease causes impaired energy metabolism and reduced developmental potential in midbrain dopaminergic cells	43
Reconstruction of dynamic regulatory networks reveals signaling-induced topology changes associated with germ layer specification	41
Patients' perspectives on the derivation and use of organoids	41
SETD4 cells contribute to brain development and maintain adult stem cell reservoir for neurogenesis	40
Insertion/deletion and microsatellite alteration profiles in induced pluripotent stem cells	40
A eutherian-specific microRNA controls the translation of Satb2 in a model of cortical differentiation	40
Rag2−/− accelerates lipofuscin accumulation in the brain: Implications for human stem cell brain transplantation studies	40
Minichromosome maintenance protein 10 (mcm10) regulates hematopoietic stem cell emergence in the zebrafish embryo	39
Prolonged generation of multi-lineage blood cells in wild-type animals from pluripotent stem cells	39
Long noncoding RNA Lnc530 localizes on R-loops and regulates R-loop formation and genomic stability in mouse embryonic stem cells	39
What has single-cell transcriptomics taught us about long non-coding RNAs in the ventricular-subventricular zone?	38
A pluripotent developmental state confers a low fidelity of chromosome segregation	38
The LRRK2 kinase substrates RAB8a and RAB10 contribute complementary but distinct disease-relevant phenotypes in human neurons	37
Deciphering the differential impact of thrombopoietin/MPL signaling on hematopoietic stem/progenitor cell function in bone marrow and spleen	35
A functional crosstalk between the H3K9 methylation writers and their reader HP1 in safeguarding embryonic stem cell identity	35
Reduction of H3K9 methylation by G9a inhibitors improves the development of mouse SCNT embryos	35
Argonaute proteins regulate a specific network of genes through KLF4 in mouse embryonic stem cells	34
Retinal transplant immunology and advancements	34
Generation, genomic characterization, and differentiation of triploid human embryonic stem cells	33
Genetic and epigenetic determinants of reactivation of Mecp2 and the inactive X chromosome in neural stem cells	33
Agarose microgel culture delineates lumenogenesis in naive and primed human pluripotent stem cells	33
Increased tissue stiffness triggers contractile dysfunction and telomere shortening in dystrophic cardiomyocytes	33
Subcellular RNA distribution and its change during human embryonic stem cell differentiation	33
NK cell content does not seem to influence engraftment in ex vivo T cell depleted haploidentical stem cell transplantation	33
ER stress and lipid imbalance drive diabetic embryonic cardiomyopathy in an organoid model of human heart development	32
Single-cell mapping of regenerative and fibrotic healing responses after musculoskeletal injury	32
Autism- and intellectual disability-associated MYT1L mutation alters human cortical interneuron differentiation, maturation, and physiology	32
Generation of innervated cochlear organoid recapitulates early development of auditory unit	32
Exclusive generation of rat spermatozoa in sterile mice utilizing blastocyst complementation with pluripotent stem cells	32
PCSK9 regulates the NODAL signaling pathway and cellular proliferation in hiPSCs	32
LOTUS overexpression via ex vivo gene transduction further promotes recovery of motor function following human iPSC-NS/PC transplantation for contusive spinal cord injury	31
Inducing human retinal pigment epithelium-like cells from somatic tissue	31
Thymic stromal lymphopoietin controls hair growth	31
Proinflammatory phenotype of iPS cell-derived JAK2 V617F megakaryocytes induces fibrosis in 3D in vitro bone marrow niche	31
Silencing of p53 and CDKN1A establishes sustainable immortalized megakaryocyte progenitor cells from human iPSCs	31
Serine Racemase mediates subventricular zone neurogenesis via fatty acid metabolism	31
CHD4 ensures stem cell lineage fidelity during skeletal muscle regeneration	30
The impact of consanguinity on the design of iPSC banks	30
Efficient transgenesis and homology-directed gene targeting in monolayers of primary human small intestinal and colonic epithelial stem cells	30
The global downregulation of protein synthesis observed during hepatogenic maturation is associated with a decrease in TOP mRNA translation	29
Tissue origin of cytotoxic natural killer cells dictates their differential roles in mouse digit tip regeneration and progenitor cell survival	29
Genome-wide analyses reveal the detrimental impacts of SARS-CoV-2 viral gene Orf9c on human pluripotent stem cell-derived cardiomyocytes	29
Characterization of N-terminal RYR2 variants outside CPVT1 hotspot regions using patient iPSCs reveal pathogenesis and therapeutic potential	29
IRX5 promotes DNA damage repair and activation of hair follicle stem cells	29

Selective elimination of pluripotent stem cells by PIKfyve specific inhibitors	29
Characterization of the epidermal-dermal junction in hiPSC-derived skin organoids	28
A phenotypic screen of Marfan syndrome iPSC-derived vascular smooth muscle cells uncovers GSK3β as a new target	28
Re-generation of cytotoxic γδT cells with distinctive signatures from human γδT-derived iPSCs	28
Plating human iPSC lines on micropatterned substrates reveals role for ITGB1 nsSNV in endoderm formation	28
Ribosomal proteins regulate 2-cell-stage transcriptome in mouse embryonic stem cells	28
Recognizing the ethical implications of stem cell research: A call for broadening the scope	28
mTORC1 mediates the expansion of hematopoietic stem and progenitor cells through ribosome biogenesis protein Urb2 in zebrafish	28
Human retinal organoids harboring IMPG2 mutations exhibit a photoreceptor outer segment phenotype that models advanced retinitis pigmentosa	28
Modulation by DREADD reveals the therapeutic effect of human iPSC-derived neuronal activity on functional recovery after spinal cord injury	27
Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies	27
Human iPSC-derived neural progenitor cells secreting GDNF provide protection in rodent models of ALS and retinal degeneration	26
Putting Science into Standards workshop on standards for organ-on-chip	26
FOXO4-SP6 axis controls surface epithelium commitment by mediating epigenomic remodeling	26
Cardiomyocytes recruit monocytes upon SARS-CoV-2 infection by secreting CCL2	26
Age-related pathological impairments in directly reprogrammed dopaminergic neurons derived from patients with idiopathic Parkinson’s disease	25
RYBP modulates embryonic neurogenesis involving the Notch signaling pathway in a PRC1-independent pattern	25
Cell-autonomous and non-cell-autonomous roles of NKCC1 in regulating neural stem cell quiescence in the hippocampal dentate gyrus	25
Familial Alzheimer’s disease-associated PSEN1 mutations affect neurodevelopment through increased Notch signaling	25
Attrition of X Chromosome Inactivation in Aged Hematopoietic Stem Cells	25
PAX6-positive microglia evolve locally in hiPSC-derived ocular organoids	25
Effect of Notch1 signaling on muscle engraftment and maturation from pluripotent stem cells	25
The relevance of mitochondrial DNA variants fluctuation during reprogramming and neuronal differentiation of human iPSCs	25
Human iPSC-based neurodevelopmental models of globoid cell leukodystrophy uncover patient- and cell type-specific disease phenotypes	25
Autophagy is essential for human myelopoiesis	25
Exploiting O-GlcNAc dyshomeostasis to screen O-GlcNAc transferase intellectual disability variants	25
CRISPR/Cas9/AAV9-mediated in vivo editing identifies MYC regulation of 3D genome in skeletal muscle stem cell	24
Ranolazine rescues the heart failure phenotype of PLN-deficient human pluripotent stem cell-derived cardiomyocytes	23
A human pluripotent stem cell-based model of SARS-CoV-2 infection reveals an ACE2-independent inflammatory activation of vascular endothelial cells through TLR4	23
Purification of human iPSC-derived cells at large scale using microRNA switch and magnetic-activated cell sorting	23
Acquisition of NOTCH dependence is a hallmark of human intestinal stem cell maturation	23
Retention of ERK in the cytoplasm mediates the pluripotency of embryonic stem cells	23
PINK1 deficiency alters muscle stem cell fate decision and muscle regenerative capacity	22
Improved hematopoietic stem cell transplantation upon inhibition of natural killer cell-derived interferon-gamma	22
Generation of functionally competent hepatic stellate cells from human stem cells to model liver fibrosis in vitro	22
Fibroblast growth factor 6 regulates sizing of the muscle stem cell pool	22
Human Pluripotent Stem Cell-Derived Intestinal Organoids Model SARS-CoV-2 Infection Revealing a Common Epithelial Inflammatory Response	21
MSCohi-O lenses for long-term retention of mesenchymal stem cells on ocular surface as a therapeutic approach for chronic ocular graft-versus-host disease	21
Differentiation of brain and retinal organoids from confluent cultures of pluripotent stem cells connected by nerve-like axonal projections of optic origin	21
A dual-color PAX7 and MYF5 in vivo reporter to investigate muscle stem cell heterogeneity in regeneration and aging	21
The chromatin accessibility landscape reveals distinct transcriptional regulation in the induction of human primordial germ cell-like cells from pluripotent stem cells	21
Eyes open on stem cells	21
Human microglial cells as a therapeutic target in a neurodevelopmental disease model	21
ALS-related p97 R155H mutation disrupts lysophagy in iPSC-derived motor neurons	21
Dissecting the impact of differentiation stage, replicative history, and cell type composition on epigenetic clocks	21
Expanding homogeneous culture of human primordial germ cell-like cells maintaining germline features without serum or feeder layers	21
Inclusivity and diversity: Integrating international perspectives on stem cell challenges and potential	20
Making neurons, made easy: The use of Neurogenin-2 in neuronal differentiation	20
Laminin111-based defined culture promoting self-renewing human pluripotent stem cells with properties of the early post-implantation epiblast	20
Erythroid precursors and progenitors suppress adaptive immunity and get invaded by SARS-CoV-2	20
Survival of an HLA-mismatched, bioengineered RPE implant in dry age-related macular degeneration	19
Differentiation success of reprogrammed cells is heterogeneous in vivo and modulated by somatic cell identity memory	19
Organoids are not organs: Sources of variation and misinformation in organoid biology	19
Auxin-degron system identifies immediate mechanisms of OCT4	19
Programming of neural progenitors of the adult subependymal zone towards a glutamatergic neuron lineage by neurogenin 2	19
High-dose radiation preferentially induces the clonal expansion of hematopoietic progenitor cells over mature T and B cells in mouse bone marrow	19
A Chemically Defined Feeder-free System for the Establishment and Maintenance of the Human Naive Pluripotent State	19
Assessing patient perception of risk in ocular stem cell therapies	19
In and out: Benchmarking in vitro, in vivo, ex vivo, and xenografting approaches for an integrative brain disease modeling pipeline	19
Cardiac differentiation roadmap for analysis of plasticity and balanced lineage commitment	19
An efficient, non-viral arrayed CRISPR screening platform for iPSC-derived myeloid and microglia models	19
Chemically defined and dynamic click hydrogels support hair cell differentiation in human inner ear organoids	19
Neuronal silence as a prosurvival factor for adult-born olfactory bulb interneurons	19
From development toward therapeutics, a collaborative effort on blood progenitors	18
Esrrb is a cell-cycle-dependent associated factor balancing pluripotency and XEN differentiation	18
Generation of pancreatic progenitors from human pluripotent stem cells by small molecules	18
TGFβ superfamily signaling regulates the state of human stem cell pluripotency and capacity to create well-structured telencephalic organoids	18
Developmental thyroid disruption permanently affects the neuroglial output in the murine subventricular zone	18
Single-cell spatiotemporal analysis reveals cell fates and functions of transplanted mesenchymal stromal cells during bone repair	18
SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants	18
Homozygous ALS-linked FUS P525L mutations cell- autonomously perturb transcriptome profile and chemoreceptor signaling in human iPSC microglia	18
The histone H3.3 chaperone HIRA restrains erythroid-biased differentiation of adult hematopoietic stem cells	18
Functional mouse hepatocytes derived from interspecies chimeric livers effectively mitigate chronic liver fibrosis	18
Remodeling of H3K9me3 during the pluripotent to totipotent-like state transition	18
Genome-wide screening reveals essential roles for HOX genes and imprinted genes during caudal neurogenesis of human embryonic stem cells	18
Patient-derived parathyroid organoids as a tracer and drug-screening application model	18
Integrated transcriptome-proteome analyses of human stem cells reveal source-dependent differences in their regenerative signature	18
Single-cell characterization of neovascularization using hiPSC-derived endothelial cells in a 3D microenvironment	18
From responsibility to responsibilization in stem cell research: An ethical framework	18
Differentiation of uniparental human embryonic stem cells into granulosa cells reveals a paternal contribution to gonadal development	18

Connie Eaves (1944–2024)	18
Protein-encapsulated doxorubicin reduces cardiotoxicity in hiPSC-cardiomyocytes and cardiac spheroids while maintaining anticancer efficacy	18
Guidelines for managing and using the digital phenotypes of pluripotent stem cell lines	18
ISSCR’s Guidelines for Stem Cell Research and Clinical Translation: Supporting development of safe and efficacious stem cell-based interventions	18
Patient-specific iPSC-derived endothelial cells reveal aberrant p38 MAPK signaling in atypical hemolytic uremic syndrome	18
Organoid models of breathing disorders reveal patterning defect of hindbrain neurons caused by PHOX2B-PARMs	18
High-throughput screening on cochlear organoids identifies VEGFR-MEK-TGFB1 signaling promoting hair cell reprogramming	17
How to promote the accessibility of technology in the era of hESC patents—A comparative analysis of the systems of the US and China	17
Unproven cell interventions in Poland and the exploitation of European Union law on advanced therapy medicinal products	17
Single-cell transcriptomics reveals correct developmental dynamics and high-quality midbrain cell types by improved hESC differentiation	17
Rescuing human fetal tissue research in the United States: A call for additional regulatory reform	17
Evidence for in vitro extensive proliferation of adult hepatocytes and biliary epithelial cells	17
A functional hiPSC-cortical neuron differentiation and maturation model and its application to neurological disorders	17
Chitinase-like protein 3: A novel niche factor for mouse neural stem cells	17
Weighing up the evidence used by direct-to-consumer stem cell businesses	17
Enrichment of stem cell-derived pancreatic beta-like cells and controlled graft size through pharmacological removal of proliferating cells	17
DOT1L regulates lung developmental epithelial cell fate and adult alveolar stem cell differentiation after acute injury	17
An acidic residue within the OCT4 dimerization interface of SOX17 is necessary and sufficient to overcome its pluripotency-inducing activity	17
Growth/differentiation factor 15 controls ependymal and stem cell number in the V-SVZ	17
Single-cell transcriptomics identifies master regulators of neurodegeneration in SOD1 ALS iPSC-derived motor neurons	17
Derivation of feeder-free human extended pluripotent stem cells	17
Differentiation of human induced pluripotent stem cells to authentic macrophages using a defined, serum-free, open-source medium	17
Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes	16
Low Immunogenicity and Immunosuppressive Properties of Human ESC- and iPSC-Derived Retinas	16
Progesterone receptor-DNA methylation crosstalk regulates depletion of uterine leiomyoma stem cells: A potential therapeutic target	16
Biomanufacturing in low Earth orbit for regenerative medicine	16
Embryo size regulates the timing and mechanism of pluripotent tissue morphogenesis	16
Characterization of hiPSC-Derived Muscle Progenitors Reveals Distinctive Markers for Myogenic Cell Purification Toward Cell Therapy	16
Dysregulated ECM remodeling proteins lead to aberrant osteogenesis of Costello syndrome iPSCs	16
Upregulation of the JAK-STAT pathway promotes maturation of human embryonic stem cell-derived cardiomyocytes	16
Non-viral Induction of Transgene-free iPSCs from Somatic Fibroblasts of Multiple Mammalian Species	16
Loss of TBX3 enhances pancreatic progenitor generation from human pluripotent stem cells	16
A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individuals	16
Physical exercise promotes integration of grafted cells and functional recovery in an acute stroke rat model	16
Survey of Japanese researchers and the public regarding the culture of human embryos in vitro beyond 14 days	15
Complex haploinsufficiency in pluripotent cells yields somatic cells with DNA methylation abnormalities and pluripotency induction defects	15
PIM3-AMPK-HDAC4/5 axis restricts MuERVL-marked 2-cell-like state in embryonic stem cells	15
IL-18R-mediated HSC quiescence and MLKL-dependent cell death limit hematopoiesis during infection-induced shock	15
Allogeneic offspring produced by induction of PD-L1 in spermatogonial stem cells via self-renewal stimulation	15
Activated mesenchymal stem/stromal cells promote myeloid cell differentiation via CCL2/CCR2 signaling	15
Patient engagement and satisfaction with early phase cell therapy clinical trials at a tertiary inflammatory bowel disease center	15
Subventricular zone adult mouse neural stem cells require insulin receptor for self-renewal	15
Pluripotent cell states and unexpected fates	15
Maternal Western-style diet remodels the transcriptional landscape of fetal hematopoietic stem and progenitor cells in rhesus macaques	15
SinCMat: A single-cell-based method for predicting functional maturation transcription factors	15
Conclusive demonstration of iatrogenic Alzheimer’s disease transmission in a model of stem cell transplantation	15
Neuroblast migration along cellular substrates in the developing porcine brain	15
Directly induced human retinal ganglion cells mimic fetal RGCs and are neuroprotective after transplantation in vivo	15