Stem Cell Reports

Papers
(The TQCC of Stem Cell Reports is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)
ArticleCitations
Genome-wide analyses reveal the detrimental impacts of SARS-CoV-2 viral gene Orf9c on human pluripotent stem cell-derived cardiomyocytes199
Expanding homogeneous culture of human primordial germ cell-like cells maintaining germline features without serum or feeder layers190
A regulatory role for CHD4 in maintenance of the spermatogonial stem cell pool158
Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies96
Reconstruction of dynamic regulatory networks reveals signaling-induced topology changes associated with germ layer specification96
Putting Science into Standards workshop on standards for organ-on-chip92
Deriving waveform parameters from calcium transients in human iPSC-derived cardiomyocytes to predict cardiac activity with machine learning91
Effect of Notch1 signaling on muscle engraftment and maturation from pluripotent stem cells84
Improved hematopoietic stem cell transplantation upon inhibition of natural killer cell-derived interferon-gamma83
A versatile in vivo platform for reversible control of transgene expression in adult tissues81
Patients' perspectives on the derivation and use of organoids79
Silencing of p53 and CDKN1A establishes sustainable immortalized megakaryocyte progenitor cells from human iPSCs78
MSCohi-O lenses for long-term retention of mesenchymal stem cells on ocular surface as a therapeutic approach for chronic ocular graft-versus-host disease73
Erythroid precursors and progenitors suppress adaptive immunity and get invaded by SARS-CoV-269
YAP signaling in horizontal basal cells promotes the regeneration of olfactory epithelium after injury67
Dissecting the impact of differentiation stage, replicative history, and cell type composition on epigenetic clocks66
Human iPSC-based neurodevelopmental models of globoid cell leukodystrophy uncover patient- and cell type-specific disease phenotypes65
Ribosomal proteins regulate 2-cell-stage transcriptome in mouse embryonic stem cells64
Familial Alzheimer’s disease-associated PSEN1 mutations affect neurodevelopment through increased Notch signaling55
USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development55
Insertion/deletion and microsatellite alteration profiles in induced pluripotent stem cells54
In and out: Benchmarking in vitro, in vivo, ex vivo, and xenografting approaches for an integrative brain disease modeling pipeline54
Connie Eaves (1944–2024)50
Bone morphogenetic protein 4 induces hematopoietic stem cell development from murine hemogenic endothelial cells in culture50
Single-cell transcriptomics reveals correct developmental dynamics and high-quality midbrain cell types by improved hESC differentiation49
Human spinal GABA neurons survive and mature in the injured nonhuman primate spinal cord48
Gains of 20q11.21 in human pluripotent stem cells: Insights from cancer research48
ISSCR’s Guidelines for Stem Cell Research and Clinical Translation: Supporting development of safe and efficacious stem cell-based interventions46
Differentiation success of reprogrammed cells is heterogeneous in vivo and modulated by somatic cell identity memory46
Single-cell characterization of neovascularization using hiPSC-derived endothelial cells in a 3D microenvironment45
DOT1L regulates lung developmental epithelial cell fate and adult alveolar stem cell differentiation after acute injury45
H1FOO-DD promotes efficiency and uniformity in reprogramming to naive pluripotency44
Single-cell approaches define two groups of mammalian oligodendrocyte precursor cells and their evolution over developmental time44
Upregulation of the JAK-STAT pathway promotes maturation of human embryonic stem cell-derived cardiomyocytes42
IL-18R-mediated HSC quiescence and MLKL-dependent cell death limit hematopoiesis during infection-induced shock41
Complex haploinsufficiency in pluripotent cells yields somatic cells with DNA methylation abnormalities and pluripotency induction defects41
Differentiation of human induced pluripotent stem cells to authentic macrophages using a defined, serum-free, open-source medium40
Functionally redundant roles of ID family proteins in spermatogonial stem cells40
Plasticity of ocular surface epithelia: Using a murine model of limbal stem cell deficiency to delineate metaplasia and transdifferentiation39
Sequential regulation of hemogenic fate and hematopoietic stem and progenitor cell formation from arterial endothelium by Ezh1/239
GP2-enriched pancreatic progenitors give rise to functional beta cells in vivo and eliminate the risk of teratoma formation38
Stabilization of cell-cell adhesions prevents symmetry breaking and locks in pluripotency in 3D gastruloids37
DPPA2, DPPA4, and other DPPA factor epigenomic functions in cell fate and cancer36
Generation of highly pure pluripotent stem cell-derived myogenic progenitor cells and myotubes36
Human fetal tissue is critical for biomedical research36
Public perceptions and expectations: Disentangling the hope and hype of organoid research35
Engineered models of the human heart: Directions and challenges35
Mechanical force-promoted osteoclastic differentiation via periodontal ligament stem cell exosomal protein ANXA335
Human neuronal networks on micro-electrode arrays are a highly robust tool to study disease-specific genotype-phenotype correlations in vitro34
What does “appropriate scientific justification” mean for the review of human pluripotent stem cell, embryo, and related research?34
Glutamine boosts intestinal stem cell-mediated small intestinal epithelial development during early weaning: Involvement of WNT signaling34
Lessons learnt, and still to learn, in first in human stem cell trials34
Gene reactivation upon erosion of X chromosome inactivation in female hiPSCs is predictable yet variable and persists through differentiation34
Spermatogonial stem cell transplantation into nonablated mouse recipient testes33
UHRF1 interacts with snRNAs and regulates alternative splicing in mouse spermatogonial stem cells33
Disease modeling of pulmonary fibrosis using human pluripotent stem cell-derived alveolar organoids33
Medium acidosis drives cardiac differentiation during mesendoderm cell fate specification from human pluripotent stem cells33
MEF2C/p300-mediated epigenetic remodeling promotes the maturation of induced cardiomyocytes33
BRD9-containing non-canonical BAF complex maintains somatic cell transcriptome and acts as a barrier to human reprogramming33
Human iPSC model reveals a central role for NOX4 and oxidative stress in Duchenne cardiomyopathy32
Epithelial-derived factors induce muscularis mucosa of human induced pluripotent stem cell-derived gastric organoids32
Response to: SARS-CoV-2 and type I interferon signaling in brain endothelial cells: Blurring the lines between friend or foe32
Searching for information about stem cells online in an age of artificial intelligence: How should the stem cell community respond?32
Neutrophils as regulators of macrophage-induced inflammation in a setting of allogeneic bone marrow transplantation31
DOT1L inhibition enhances pluripotency beyond acquisition of epithelial identity and without immediate suppression of the somatic transcriptome31
Depletion of WFS1 compromises mitochondrial function in hiPSC-derived neuronal models of Wolfram syndrome31
Upregulation of β-catenin due to loss of miR-139 contributes to motor neuron death in amyotrophic lateral sclerosis31
Human pluripotent stem cell-derived eosinophils reveal potent cytotoxicity against solid tumors31
Ethics and regulatory considerations for the clinical translation of somatic cell human epigenetic editing31
A single cell-based computational platform to identify chemical compounds targeting desired sets of transcription factors for cellular conversion30
In vitro expanded skeletal myogenic progenitors from pluripotent stem cell-derived teratomas have high engraftment capacity30
Early reactivation of clustered genes on the inactive X chromosome during somatic cell reprogramming30
Transplantation of human pluripotent stem cell-derived retinal sheet in a primate model of macular hole30
Inhibition of BMP signaling with LDN 193189 can influence bone marrow stromal cell fate but does not prevent hypertrophy during chondrogenesis30
Non-canonical roles of CFH in retinal pigment epithelial cells revealed by dysfunctional rare CFH variants30
Regeneration of spermatogenesis by mouse germ cell transplantation into allogeneic and xenogeneic testis primordia or organoids28
CD49b identifies functionally and epigenetically distinct subsets of lineage-biased hematopoietic stem cells28
Low fucosylation defines the glycocalyx of progenitor cells and melanocytes in the human limbal stem cell niche28
Metabolic remodeling in hiPSC-derived myofibers carrying the m.3243A>G mutation28
Astrocytes modulate neurodegenerative phenotypes associated with glaucoma in OPTN(E50K) human stem cell-derived retinal ganglion cells28
Parallel use of human stem cell lung and heart models provide insights for SARS-CoV-2 treatment27
DeePhys: A machine learning–assisted platform for electrophysiological phenotyping of human neuronal networks27
Granulin loss of function in human mature brain organoids implicates astrocytes in TDP-43 pathology27
Molecular profiling of stem cell-derived retinal pigment epithelial cell differentiation established for clinical translation27
Aggregation of cryopreserved mid-hindgut endoderm for more reliable and reproducible hPSC-derived small intestinal organoid generation26
Induction of astrocyte reactivity promotes neurodegeneration in human pluripotent stem cell models26
Interspecies chimerism with human embryonic stem cells generates functional human dopamine neurons at low efficiency26
AAV-mediated gene augmentation therapy of CRB1 patient-derived retinal organoids restores the histological and transcriptional retinal phenotype26
Involvement of LIN28A in Wnt-dependent regulation of hippocampal neurogenesis in the aging brain26
Prosaposin maintains adult neural stem cells in a state associated with deep quiescence26
Patient-specific and gene-corrected induced pluripotent stem cell-derived endothelial cells elucidate single-cell phenotype of pulmonary veno-occlusive disease26
Titin-truncating variants in hiPSC cardiomyocytes induce pathogenic proteinopathy and sarcomere defects with preserved core contractile machinery26
Matthias Lutolf, interviewed by Peter Loskill (Vice-Chair of EUROoC, the European-Organ-on-Chip-Society)26
Mowat-Wilson syndrome factor ZEB2 controls early formation of human neural crest through BMP signaling modulation26
Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes25
ISSCR guidelines for the transfer of human pluripotent stem cells and their direct derivatives into animal hosts25
The trophectoderm acts as a niche for the inner cell mass through C/EBPα-regulated IL-6 signaling25
Modeling sex differences in humans using isogenic induced pluripotent stem cells25
Modeling reduced contractility and impaired desmosome assembly due to plakophilin-2 deficiency using isogenic iPS cell-derived cardiomyocytes25
Generation of canine induced pluripotent stem cells under feeder-free conditions using Sendai virus vector encoding six canine reprogramming factors25
Astrocytic reactivity triggered by defective autophagy and metabolic failure causes neurotoxicity in frontotemporal dementia type 325
Derivation of functional trophoblast stem cells from primed human pluripotent stem cells24
Taking the leap toward human-specific nonanimal methodologies: The need for harmonizing global policies for microphysiological systems24
Embryonic stem cell ERK, AKT, plus STAT3 response dynamics combinatorics are heterogeneous but NANOG state independent23
Ribosome biogenesis controls cranial suture MSC fate via the complement pathway in mouse and human iPSC models23
Fractalkine enhances oligodendrocyte regeneration and remyelination in a demyelination mouse model23
Reconstituted ovaries self-assemble without an ovarian surface epithelium23
Fibroblast fate determination during cardiac reprogramming by remodeling of actin filaments23
Critical considerations for public engagement in stem cell-related research23
Small-molecule inhibitor cocktail promotes the proliferation of pre-existing liver progenitor cells23
Deep-supercooling preservation of stem cell spheroids for chondral defect repairment23
Businesses marketing purported stem cell treatments and exosome therapies for COVID-19: An analysis of direct-to-consumer online advertising claims22
Identification of glioblastoma stem cell-associated lncRNAs using single-cell RNA sequencing datasets22
Aberrant nucleosome organization in mouse SCNT embryos revealed by ULI-MNase-seq22
Dual inhibition of MAPK and PI3K/AKT pathways enhances maturation of human iPSC-derived cardiomyocytes22
Micro-patterned culture of iPSC-derived alveolar and airway cells distinguishes SARS-CoV-2 variants22
A year of engagement and growth: ISSCR’s year-end message from the president 2022–202322
Scalable generation of sensory neurons from human pluripotent stem cells22
CD62L expression level determines the cell fate of myeloid progenitors22
Rostrocaudal patterning and neural crest differentiation of human pre-neural spinal cord progenitors in vitro22
The Wnt-dependent master regulator NKX1-2 controls mouse pre-implantation development22
Human primed and naïve PSCs are both able to differentiate into trophoblast stem cells21
Prolonged generation of multi-lineage blood cells in wild-type animals from pluripotent stem cells21
Astrocytes originated from neural stem cells drive the regenerative remodeling of pathologic CSPGs in spinal cord injury21
Perinuclear mitochondrial clustering for mesenchymal-to-epithelial transition in pluripotency induction21
MIXL1 activation in endoderm differentiation of human induced pluripotent stem cells21
A BMP4-p38 MAPK signaling axis controls ISL1 protein stability and activity during cardiogenesis21
LOTUS overexpression via ex vivo gene transduction further promotes recovery of motor function following human iPSC-NS/PC transplantation for contusive spinal cord injury21
Defining the nature of human pluripotent stem cell-derived interneurons via single-cell analysis21
DDX41 is needed for pre- and postnatal hematopoietic stem cell differentiation in mice21
Uncoupling key determinants of hematopoietic stem cell engraftment through cell-specific and temporally controlled recipient conditioning21
Reprogramming epiblast stem cells into pre-implantation blastocyst cell-like cells20
Argonaute proteins regulate a specific network of genes through KLF4 in mouse embryonic stem cells20
The relevance of mitochondrial DNA variants fluctuation during reprogramming and neuronal differentiation of human iPSCs20
MAC-1 marks a quiescent and functionally superior HSC subset during regeneration20
Inducing human retinal pigment epithelium-like cells from somatic tissue20
Generation, genomic characterization, and differentiation of triploid human embryonic stem cells20
Human iPSC-derived neural progenitor cells secreting GDNF provide protection in rodent models of ALS and retinal degeneration20
Increased tissue stiffness triggers contractile dysfunction and telomere shortening in dystrophic cardiomyocytes19
Cell-autonomous and non-cell-autonomous roles of NKCC1 in regulating neural stem cell quiescence in the hippocampal dentate gyrus19
Purification of human iPSC-derived cells at large scale using microRNA switch and magnetic-activated cell sorting19
Selective elimination of pluripotent stem cells by PIKfyve specific inhibitors19
Differentiation of brain and retinal organoids from confluent cultures of pluripotent stem cells connected by nerve-like axonal projections of optic origin19
Long noncoding RNA Lnc530 localizes on R-loops and regulates R-loop formation and genomic stability in mouse embryonic stem cells19
RYBP modulates embryonic neurogenesis involving the Notch signaling pathway in a PRC1-independent pattern19
The global downregulation of protein synthesis observed during hepatogenic maturation is associated with a decrease in TOP mRNA translation19
ER stress and lipid imbalance drive diabetic embryonic cardiomyopathy in an organoid model of human heart development19
Zika virus induces FOXG1 nuclear displacement and downregulation in human neural progenitors19
Chitinase-like protein 3: A novel niche factor for mouse neural stem cells19
Human microglial cells as a therapeutic target in a neurodevelopmental disease model19
Auxin-degron system identifies immediate mechanisms of OCT418
Pluripotent cell states and unexpected fates18
A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells18
Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes18
Accelerated mitochondrial dynamics promote spermatogonial differentiation18
An efficient, non-viral arrayed CRISPR screening platform for iPSC-derived myeloid and microglia models18
Survival of an HLA-mismatched, bioengineered RPE implant in dry age-related macular degeneration18
Reprogramming astrocytes to motor neurons by activation of endogenous Ngn2 and Isl118
Neuroblast migration along cellular substrates in the developing porcine brain18
SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants18
ERRγ agonist under mechanical stretching manifests hypertrophic cardiomyopathy phenotypes of engineered cardiac tissue through maturation18
Oligodendrocytes in human induced pluripotent stem cell-derived cortical grafts remyelinate adult rat and human cortical neurons18
Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells18
A Chemically Defined Feeder-free System for the Establishment and Maintenance of the Human Naive Pluripotent State18
Defective autophagy and increased apoptosis contribute toward the pathogenesis of FKRP-associated muscular dystrophies18
Rescuing human fetal tissue research in the United States: A call for additional regulatory reform18
Subventricular zone adult mouse neural stem cells require insulin receptor for self-renewal18
Seamless and non-destructive monitoring of extracellular microRNAs during cardiac differentiation from human pluripotent stem cells18
Interleukin-1β induces trained innate immunity in human hematopoietic progenitor cells in vitro18
Patient-derived parathyroid organoids as a tracer and drug-screening application model18
Self-assembling 3D vessel-on-chip model with hiPSC-derived astrocytes18
Derivation of transplantable human thyroid follicular epithelial cells from induced pluripotent stem cells18
Spatial transcriptomics reveals molecular cues underlying the site specificity of the adult mouse oral mucosa and its stem cell niches18
Genetic variation modulates susceptibility to aberrant DNA hypomethylation and imprint deregulation in naive pluripotent stem cells17
Safe CNV removal is crucial for successful hESC-RPE transplantation in wet age-related macular degeneration17
Cell size regulates human endoderm specification through actomyosin-dependent AMOT-YAP signaling17
PI3Kβ-regulated β-catenin mediates EZH2 removal from promoters controlling primed human ESC stemness and primitive streak gene expression17
Swift induction of human spinal lower motor neurons and robust ALS cell screening via single-cell imaging17
PBX1-directed stem cell transcriptional program drives tumor progression in myeloproliferative neoplasm17
A critical role of retinoic acid concentration for the induction of a fully human-like atrial action potential phenotype in hiPSC-CM17
SnapShot: Reporting practices for publishing results with human PSCs and tissue stem cells17
Pluripotent stem cell–derived corneal endothelial cells as an alternative to donor corneal endothelium in keratoplasty17
DOT1L interaction partner AF10 controls patterning of H3K79 methylation and RNA polymerase II to maintain cell identity17
Cell position within human pluripotent stem cell colonies determines apical specialization via an actin cytoskeleton-based mechanism17
SALL3 mediates the loss of neuroectodermal differentiation potential in human embryonic stem cells with chromosome 18q loss17
Sleep deprivation induces corneal epithelial progenitor cell over-expansion through disruption of redox homeostasis in the tear film17
AT7867 promotes pancreatic progenitor differentiation of human iPSCs16
The urgent need for clear and concise regulations on exosome-based interventions16
Generation of a TPH2-EGFP reporter cell line for purification and monitoring of human serotonin neurons in vitro and in vivo16
Human iPSC-derived photoreceptor transplantation in the cone dominant 13-lined ground squirrel16
Transcription factor co-expression mediates lineage priming for embryonic and extra-embryonic differentiation16
Unraveling the impact of ZZZ3 on the mTOR/ribosome pathway in human embryonic stem cells homeostasis16
Screening of factors inducing alveolar type 1 epithelial cells using human pluripotent stem cells16
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