OOIR: Observatory of International Research

Papers

(The H4-Index of Redox Biology is 80. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
An inducible long noncoding RNA, LncZFHX2, facilitates DNA repair to mediate osteoarthritis pathology	367
SOD2 orchestrates redox homeostasis in intervertebral discs: A novel insight into oxidative stress-mediated degeneration and therapeutic potential	332
GAPDH inhibition mediated by thiol oxidation in human airway epithelial cells exposed to an environmental peroxide	296
Glutathione peroxidase 3 is essential for countering senescence in adipose remodelling by maintaining mitochondrial homeostasis	273
Synergistic induction of ferroptosis by targeting HERC1-NCOA4 axis to enhance the photodynamic sensitivity of osteosarcoma	243
A quantitative proteomic approach to evaluate the efficacy of carnosine in a murine model of chronic obstructive pulmonary disease (COPD)	219
Mechano-activated connexin hemichannels and glutathione transport protect lens fiber cells against oxidative insults	202
Small extracellular vesicles orchestrated pathological communications between breast cancer cells and cardiomyocytes as a novel mechanism exacerbating anthracycline cardiotoxicity by fueling ferroptos	190
Thioredoxin-interacting protein as a crucial regulator in asthma exacerbation induced by copper oxide nanoparticles in a mouse model	187
Oxidative stress response and NRF2 signaling pathway in autism spectrum disorder	184
PM2.5-induced iron homeostasis imbalance triggers cardiac hypertrophy through ferroptosis in a selective autophagy crosstalk manner	180
Autophagy activation is required for N6-methyladenosine modification to regulate ferroptosis in hepatocellular carcinoma	176
Coronin 1a-mediated F-actin disassembly controls effector function in murine neutrophils	174
OXPHOS inhibition overcomes chemoresistance in triple negative breast cancer	174
Microglial Nrf2-mediated lipid and iron metabolism reprogramming promotes remyelination during white matter ischemia	173
The protective role of GPX4 in naïve ESCs is highlighted by induced ferroptosis resistance through GPX4 expression	172
Factors driving the inter-individual variability in the metabolism and bioavailability of (poly)phenolic metabolites: A systematic review of human studies	171
Apolipoprotein E is required for brain iron homeostasis in mice	168
Fatty acid nitroalkenes – Multi-target agents for the treatment of sickle cell disease	164
Corrigendum to “N-butylphthalide (NBP) and ligustrazine (TMP) triazole hybrids target the KEAP1-NRF2 pathway to inhibit ferroptosis and exert brain neuroprotectivity” [Redox Biol. 86, (2025), 103835]	158
Loss of selenoprotein W in murine macrophages alters the hierarchy of selenoprotein expression, redox tone, and mitochondrial functions during inflammation	150
Adaptive responses of neuronal cells to chronic endoplasmic reticulum (ER) stress	150
ROS promote hyper-methylation of NDRG2 promoters in a DNMTS-dependent manner: Contributes to the progression of renal fibrosis	150
Organic Selenium induces ferroptosis in pancreatic cancer cells	150
Fullerol rescues the light-induced retinal damage by modulating Müller glia cell fate	149

Mitochondria spatially and temporally modulate VSMC phenotypes via interacting with cytoskeleton in cardiovascular diseases	148
CypD induced ROS output promotes intracranial aneurysm formation and rupture by 8-OHdG/NLRP3/MMP9 pathway	137
Acute lymphoblastic leukemia necessitates GSH-dependent ferroptosis defenses to overcome FSP1-epigenetic silencing	134
Inhibition of spinal ferroptosis-like cell death alleviates hyperalgesia and spontaneous pain in a mouse model of bone cancer pain	134
SIRT1 attenuates blood-spinal cord barrier disruption after spinal cord injury by deacetylating p66Shc	129
Decreased expression of mitochondrial aminoacyl-tRNA synthetases causes downregulation of OXPHOS subunits in type 2 diabetic muscle	127
FTO ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via P53–P21/Nrf2 activation in a HuR-dependent m6A manner	126
Silica nanoparticles aggravated the metabolic associated fatty liver disease through disturbed amino acid and lipid metabolisms-mediated oxidative stress	125
Type 2 Diabetes mellitus alters the cargo of (poly)phenol metabolome and the oxidative status in circulating lipoproteins	124
Multi-omics profiling reveals Chitinase-3-like protein 1 as a key mediator in the crosstalk between sarcopenia and liver cancer	117
Peroxiredoxin 3 deficiency induces cardiac hypertrophy and dysfunction by impaired mitochondrial quality control	116
The mammalian peroxisomal membrane is permeable to both GSH and GSSG – Implications for intraperoxisomal redox homeostasis	116
NADPH oxidase 1: A target in the capacity of dimeric ECG and EGCG procyanidins to inhibit colorectal cancer cell invasion	114
Integrated regulation of stress responses, autophagy and survival by altered intracellular iron stores	110
Human ultrarare genetic disorders of sulfur metabolism demonstrate redundancies in H2S homeostasis	110
Seizures, ataxia and parvalbumin-expressing interneurons respond to selenium supply in Selenop-deficient mice	109
The antioxidant and oxidant properties of hydropersulfides (RSSH) and polysulfide species	108
The influence of vitamin D supplementation and strength training on health biomarkers and chromosomal damage in community-dwelling older adults	108
Modulation of muscle redox and protein aggregation rescues lethality caused by mutant lamins	106
A promising drug repurposing approach for Alzheimer's treatment: Givinostat improves cognitive behavior and pathological features in APP/PS1 mice	104
Endothelial MerTK impairment accelerates the development of atherosclerosis	103
Dimethyl fumarate ameliorates erectile dysfunction in bilateral cavernous nerve injury rats by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis of nerve via activation of Nrf2/HO	102
Cooperation between CYB5R3 and NOX4 via coenzyme Q mitigates endothelial inflammation	102
TRPM7 channel inhibition attenuates rheumatoid arthritis articular chondrocyte ferroptosis by suppression of the PKCα-NOX4 axis	101
Thioredoxin (Trx): A redox target and modulator of cellular senescence and aging-related diseases	101
Role of DDX1 in the oxidative response of ataxia telangiectasia patient-derived fibroblasts	99
Redox shuttle of cytosolic Thioredoxin to mitochondria protects against hyperoxia-mediated alteration of mitochondrial structure and dysfunction	98
Myeloid ACE2 protects against septic hypotension and vascular dysfunction through Ang-(1–7)-Mas-mediated macrophage polarization	97
Peroxiredoxin Ⅲ mitigates mitochondrial H2O2-mediated damage and supports quality control in cardiomyocytes under hypoxia-reoxygenation stress	96
Age-related declines in mitochondrial Prdx6 contribute to dysregulated muscle bioenergetics	96
Acute stimulation of glucose metabolism by H2O2 sustains the NADPH steady-state under oxidative stress	95
Disulfide stress and its role in cardiovascular diseases	95
Retraction notice to “Autophagy regulates turnover of lipid droplets via ROS-dependent Rab25 activation in hepatic stellate cell” [Redox Biol. 11 (2017) 322–334]	94
Supplement-driven iron overload accelerates phenotypic aging via inflammatory biomarkers: Potential counteraction through anti-inflammatory or antioxidant diets	94
Cytoglobin scavenges intracellular hydrogen peroxide and regulates redox signals in the vasculature	93
Poor glycaemic control in type 2 diabetes compromises leukocyte oxygen consumption rate, OXPHOS complex content and neutrophil-endothelial interactions	93
A model of mitochondrial superoxide production during ischaemia-reperfusion injury for therapeutic development and mechanistic understanding	91
Dietary sulfur amino acid restriction in humans with overweight and obesity: Evidence of an altered plasma and urine sulfurome, and a novel metabolic signature that correlates with loss of fat mass an	90
Development of nitroalkene-based inhibitors to target STING-dependent inflammation	90
Sweroside alleviates pressure overload-induced heart failure through targeting CaMKⅡδ to inhibit ROS-mediated NF-κB/NLRP3 in cardiomyocytes	90
Selenium deficiency impedes maturation of parvalbumin interneurons, perineuronal nets, and neural network activity	90
Accumulation of acetaldehyde in aldh2.1 zebrafish causes increased retinal angiogenesis and impaired glucose metabolism	90
HDAC6 inhibitor-loaded brain-targeted nanocarrier-mediated neuroprotection in methamphetamine-driven Parkinson's disease	90
Endothelial peroxynitrite causes disturbance of neuronal oscillations by targeting caspase-1 in the arcuate nucleus	89
Biochemical and structural characterizations of thioredoxin reductase selenoproteins of the parasitic filarial nematodes Brugia malayi and Onchocerca volvulus	89
CircSV2b participates in oxidative stress regulation through miR-5107-5p-Foxk1-Akt1 axis in Parkinson's disease	87
Inhibition of mitochondrial complex I leading to NAD+/NADH imbalance in type 2 diabetic patients who developed late stent thrombosis: Evidence from an integrative analysis of platelet bioenergetics an	87
ALDH2 deficiency increases susceptibility to binge alcohol-induced gut leakiness, endotoxemia, and acute liver injury in mice through the gut-liver axis	86
Corrigendum to “Natural mutations of human XDH promote the nitrite (NO2−)-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health?” [Redox Biol. 4 (67) (2023) 102864]	85
Hyperglycemia triggers RyR2-dependent alterations of mitochondrial calcium homeostasis in response to cardiac ischemia-reperfusion: Key role of DRP1 activation	83

Nutrigenomics and redox regulation: Concepts relating to the Special Issue on nutrigenomics	83
New insights into extracellular and intracellular redox status in COVID-19 patients	82
Fatty acid nitroalkene reversal of established lung fibrosis	82
REV-ERBα regulates age-related and oxidative stress-induced degeneration in retinal pigment epithelium via NRF2	81
Recovery of reduced thiol groups by superoxide-mediated denitrosation of nitrosothiols	80