Molecular Metabolism

Article	Citations
GLP-1 receptor agonists in the treatment of type 2 diabetes – state-of-the-art	700
Metabolic-associated fatty liver disease and lipoprotein metabolism	266
Dysregulated lipid metabolism links NAFLD to cardiovascular disease	265
GLP-1 physiology informs the pharmacotherapy of obesity	180
Nonalcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans	178
Glucagon-like peptide-1 receptor co-agonists for treating metabolic disease	171
A guide to understanding endoplasmic reticulum stress in metabolic disorders	169
Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street	154
Role of NAD+ in regulating cellular and metabolic signaling pathways	149
The melanocortin pathway and energy homeostasis: From discovery to obesity therapy	132
Insulin-like growth factors: Ligands, binding proteins, and receptors	128
Insulin action at a molecular level – 100 years of progress	123
Hepatic lipid droplets: A balancing act between energy storage and metabolic dysfunction in NAFLD	122
Hepatokines and metabolism: Deciphering communication from the liver	120
Imaging biomarkers of NAFLD, NASH, and fibrosis	112
Metabolic drivers of non-alcoholic fatty liver disease	110
The brain as an insulin-sensitive metabolic organ	101
Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis	96
Genetic and epigenetic factors determining NAFLD risk	88
CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing	87
GLP-1 improves the supportive ability of astrocytes to neurons by promoting aerobic glycolysis in Alzheimer's disease	79
Glucagon acutely regulates hepatic amino acid catabolism and the effect may be disturbed by steatosis	75
Single-cell transcriptomics of human islet ontogeny defines the molecular basis of β-cell dedifferentiation in T2D	74
Targeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms	73
Ferroptosis and ferritinophagy in diabetes complications	73

Nicotinamide N-methyltransferase: At the crossroads between cellular metabolism and epigenetic regulation	71
Understanding insulin and its receptor from their three-dimensional structures	68
Overexpression of the vitamin D receptor (VDR) induces skeletal muscle hypertrophy	66
Exploring the therapeutic potential of mitochondrial uncouplers in cancer	64
Chronic inflammation and the hallmarks of aging	64
Sodium-glucose co-transporter2 expression and inflammatory activity in diabetic atherosclerotic plaques: Effects of sodium-glucose co-transporter2 inhibitor treatment	63
Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice	63
Wnt/β-catenin signaling regulates adipose tissue lipogenesis and adipocyte-specific loss is rigorously defended by neighboring stromal-vascular cells	62
Mitochondrial oxidative function in NAFLD: Friend or foe?	61
Infusion of donor feces affects the gut–brain axis in humans with metabolic syndrome	59
Role and mechanism of ferroptosis in neurological diseases	58
Therapeutic potential of mitochondrial uncouplers for the treatment of metabolic associated fatty liver disease and NASH	56
Iron aggravates hepatic insulin resistance in the absence of inflammation in a novel db/db mouse model with iron overload	56
Impacts of essential amino acids on energy balance	54
BI 456906: Discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy	51
FGF19 and FGF21: In NASH we trust	51
Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists	49
Sperm histone H3 lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunction	48
A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing	47
LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue	46
Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction	46
Maternal obesity causes fetal hypothalamic insulin resistance and disrupts development of hypothalamic feeding pathways	45
Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat	44
Non-alcoholic fatty liver disease and steatohepatitis: State of the art on effective therapeutics based on the gold standard method for diagnosis	43
Exercise of high intensity ameliorates hepatic inflammation and the progression of NASH	43
Organelle transporters and inter-organelle communication as drivers of metabolic regulation and cellular homeostasis	43
MicroRNAs in non-alcoholic fatty liver disease: Progress and perspectives	43
LKB1 deficiency-induced metabolic reprogramming in tumorigenesis and non-neoplastic diseases	43
Hmgcs2-mediated ketogenesis modulates high-fat diet-induced hepatosteatosis	42
LDLR inhibition promotes hepatocellular carcinoma proliferation and metastasis by elevating intracellular cholesterol synthesis through the MEK/ERK signaling pathway	42
Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior	42
Dopamine D2 receptor agonist, bromocriptine, remodels adipose tissue dopaminergic signalling and upregulates catabolic pathways, improving metabolic profile in type 2 diabetes	41
Hepatocyte miR-34a is a key regulator in the development and progression of non-alcoholic fatty liver disease	41
Testosterone metabolites differentially regulate obesogenesis and fat distribution	40
Hypoxia-inducible lipid droplet-associated induces DGAT1 and promotes lipid storage in hepatocytes	39
Insulin's actions on vascular tissues: Physiological effects and pathophysiological contributions to vascular complications of diabetes	38
Update on the effects of energy metabolism in bone marrow mesenchymal stem cells differentiation	38
Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo	37
Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity	37
Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and diurnal rhythms	37
Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function	37
CD81 marks immature and dedifferentiated pancreatic β-cells	36
Comparative analysis of oral and intraperitoneal glucose tolerance tests in mice	36
An accomplice more than a mere victim: The impact of β-cell ER stress on type 1 diabetes pathogenesis	35
Skeletal muscle undergoes fiber type metabolic switch without myosin heavy chain switch in response to defective fatty acid oxidation	35
The hepatocyte IKK:NF-κB axis promotes liver steatosis by stimulating de novo lipogenesis and cholesterol synthesis	35
Cardiovascular protection by SGLT2 inhibitors – Do anti-inflammatory mechanisms play a role?	35
Serum amyloid A1 exacerbates hepatic steatosis via TLR4-mediated NF-κB signaling pathway	35
Challenges in tackling energy expenditure as obesity therapy: From preclinical models to clinical application	35
Insulin resistance is mechanistically linked to hepatic mitochondrial remodeling in non-alcoholic fatty liver disease	35

Microbiota and body weight control: Weight watchers within?	34
Exposure to low-dose perfluorooctanoic acid promotes hepatic steatosis and disrupts the hepatic transcriptome in mice	34
Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation	34
Tirzepatide induces a thermogenic-like amino acid signature in brown adipose tissue	34
The gut–brain axis: Identifying new therapeutic approaches for type 2 diabetes, obesity, and related disorders	34
Purification of pancreatic endocrine subsets reveals increased iron metabolism in beta cells	33
Mitochondrial function in intestinal epithelium homeostasis and modulation in diet-induced obesity	33
p21 induces a senescence program and skeletal muscle dysfunction	33
Reappraisal of the optimal fasting time for insulin tolerance tests in mice	33
RNA m6A reader IMP2/IGF2BP2 promotes pancreatic β-cell proliferation and insulin secretion by enhancing PDX1 expression	32
Whole-brain activation signatures of weight-lowering drugs	32
Glucose-induced insulin secretion in isolated human islets: Does it truly reflect β-cell function in vivo?	32
Growth differentiation factor 15 as a potential therapeutic for treating obesity	32
Ovarian cancer modulates the immunosuppressive function of CD11b+Gr1+ myeloid cells via glutamine metabolism	32
Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis	31
Parathyroid hormone (PTH) regulation of metabolic homeostasis: An old dog teaches us new tricks	31
Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance	31
Review: Glucose-sensitive insulin	31
Time and metabolic state-dependent effects of GLP-1R agonists on NPY/AgRP and POMC neuronal activity in vivo	30
Dpp4+ interstitial progenitor cells contribute to basal and high fat diet-induced adipogenesis	30
ATF4-mediated transcriptional regulation protects against β-cell loss during endoplasmic reticulum stress in a mouse model	30
Metformin-induced reductions in tumor growth involves modulation of the gut microbiome	30
Gut microbiota impairs insulin clearance in obese mice	30
Nuclear receptors and transcriptional regulation in non-alcoholic fatty liver disease	29
A novel lncRNA RP11-386G11.10 reprograms lipid metabolism to promote hepatocellular carcinoma progression	29
Ceramides are necessary and sufficient for diet-induced impairment of thermogenic adipocytes	29
Early induction of hepatic deiodinase type 1 inhibits hepatosteatosis during NAFLD progression	29
Toward modeling metabolic state from single-cell transcriptomics	29
SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans	29
Reversal of diet-induced hepatic steatosis by peripheral CB1 receptor blockade in mice is p53/miRNA-22/SIRT1/PPARα dependent	29
Increased glycolysis affects β-cell function and identity in aging and diabetes	28
Genetic activation of α-cell glucokinase in mice causes enhanced glucose-suppression of glucagon secretion during normal and diabetic states	28
Serum integrative omics reveals the landscape of human diabetic kidney disease	28
New dawn for cancer cell death: Emerging role of lipid metabolism	28
Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis	28
Peroxisomal regulation of energy homeostasis: Effect on obesity and related metabolic disorders	27
Novel noncoding RNA CircPTK2 regulates lipolysis and adipogenesis in cachexia	27
Aster-B coordinates with Arf1 to regulate mitochondrial cholesterol transport	27
Glucocorticoids coordinate macrophage metabolism through the regulation of the tricarboxylic acid cycle	27
Adipose tissue macrophages: Regulators of adipose tissue immunometabolism during obesity	27
Stress kinases in the development of liver steatosis and hepatocellular carcinoma	27
Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression	27
“A LEAP 2 conclusions? Targeting the ghrelin system to treat obesity and diabetes”	27
P2Y2R contributes to the development of diabetic nephropathy by inhibiting autophagy response	27
Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network	26
LANCL1 binds abscisic acid and stimulates glucose transport and mitochondrial respiration in muscle cells via the AMPK/PGC-1α/Sirt1 pathway	26
Day-night rhythm of skeletal muscle metabolism is disturbed in older, metabolically compromised individuals	26
Regulation of inflammation in diabetes: From genetics to epigenomics evidence	26
β-catenin regulates muscle glucose transport via actin remodelling and M-cadherin binding	26
Tryptophan metabolism is a physiological integrator regulating circadian rhythms	26
Mono and dual agonists of the amylin, calcitonin, and CGRP receptors and their potential in metabolic diseases	26
Regulation of body weight: Lessons learned from bariatric surgery	25
17β-estradiol promotes acute refeeding in hungry mice via membrane-initiated ERα signaling	25
Multiple metabolic pathways fuel the truncated tricarboxylic acid cycle of the prostate to sustain constant citrate production and secretion	25
Nutrient sensing in the nucleus of the solitary tract mediates non-aversive suppression of feeding via inhibition of AgRP neurons	25
Prolonged fasting drives a program of metabolic inflammation in human adipose tissue	25
Nox4 mediates skeletal muscle metabolic responses to exercise	25
The role of exercise-induced peripheral factors in sleep regulation	25
The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR	25
Adipocytes fail to maintain cellular identity during obesity due to reduced PPARγ activity and elevated TGFβ-SMAD signaling	25
Free fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice	25
Neuroanatomical organization and functional roles of PVN MC4R pathways in physiological and behavioral regulations	24
Genetic loss of AMPK-glycogen binding destabilises AMPK and disrupts metabolism	24
Adaptive thermogenesis in brown adipose tissue involves activation of pannexin-1 channels	24
Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling	24
In celebration of a century with insulin – Update of insulin gene mutations in diabetes	24
NFE2L1-mediated proteasome function protects from ferroptosis	24
Adipocyte CAMK2 deficiency improves obesity-associated glucose intolerance	24
Mitochondrial pyruvate carrier inhibition initiates metabolic crosstalk to stimulate branched chain amino acid catabolism	24
Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR–v-ATPase axis	23
Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems	23
Ablation of glucokinase-expressing tanycytes impacts energy balance and increases adiposity in mice	23
Muscle NAD+ depletion and Serpina3n as molecular determinants of murine cancer cachexia—the effects of blocking myostatin and activins	23
Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity	23
Loss of mitochondrial aconitase promotes colorectal cancer progression via SCD1-mediated lipid remodeling	23
URAT1-selective inhibition ameliorates insulin resistance by attenuating diet-induced hepatic steatosis and brown adipose tissue whitening in mice	23
The effects of housing density on mouse thermal physiology depend on sex and ambient temperature	23
Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions	23
A transcriptional cross species map of pancreatic islet cells	22
Brown adipocyte-specific knockout of Bmal1 causes mild but significant thermogenesis impairment in mice	22

Ketogenic diet administration to mice after a high-fat-diet regimen promotes weight loss, glycemic normalization and induces adaptations of ketogenic pathways in liver and kidney	22
Lactate activation of α-cell KATP channels inhibits glucagon secretion by hyperpolarizing the membrane potential and reducing Ca2+ entry	22
Glucagon-like Peptide-1 receptor Tie2+ cells are essential for the cardioprotective actions of liraglutide in mice with experimental myocardial infarction	22
Daily running enhances molecular and physiological circadian rhythms in skeletal muscle	22
Emerging diabetes therapies: Bringing back the β-cells	22
Targeting cellular senescence in metabolic disease	22
Sex differences in islet stress responses support female β cell resilience	22
What is a β cell? – Chapter I in the Human Islet Research Network (HIRN) review series	21
FGF15/19 is required for adipose tissue plasticity in response to thermogenic adaptations	21
GLP-1 and hunger modulate incentive motivation depending on insulin sensitivity in humans	21
Roux-en-Y gastric bypass contributes to weight loss-independent improvement in hypothalamic inflammation and leptin sensitivity through gut-microglia-neuron-crosstalk	21
Insulin and obesity transform hypothalamic-pituitary-adrenal axis stemness and function in a hyperactive state	21
TFEB deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality	20
Intestinal stem cell-derived enteroids from morbidly obese patients preserve obesity-related phenotypes: Elevated glucose absorption and gluconeogenesis	20
Refeeding activates neurons in the dorsomedial hypothalamus to inhibit food intake and promote positive valence	20
Type 2 diabetes subgroups and potential medication strategies in relation to effects on insulin resistance and beta-cell function: A step toward personalised diabetes treatment?	20
Sensory neurons expressing calcitonin gene-related peptide α regulate adaptive thermogenesis and diet-induced obesity	20
Metabolic therapy and bioenergetic analysis: The missing piece of the puzzle	20
BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice	20
Osteocalcin and vascular function: is there a cross-talk?	20
Upregulated ethanolamine phospholipid synthesis via selenoprotein I is required for effective metabolic reprogramming during T cell activation	20
KBP-066A, a long-acting dual amylin and calcitonin receptor agonist, induces weight loss and improves glycemic control in obese and diabetic rats	20
Structural principles of insulin formulation and analog design: A century of innovation	20
Pharmacological blockade of the EP3 prostaglandin E2 receptor in the setting of type 2 diabetes enhances β-cell proliferation and identity and relieves oxidative damage	19
Proteasome dysfunction disrupts adipogenesis and induces inflammation via ATF3	19
Endothelial arginase 2 mediates retinal ischemia/reperfusion injury by inducing mitochondrial dysfunction	19
Activation of SIK1 by phanginin A inhibits hepatic gluconeogenesis by increasing PDE4 activity and suppressing the cAMP signaling pathway	19
Disabling MNK protein kinases promotes oxidative metabolism and protects against diet-induced obesity	19
Insulin resistance per se drives early and reversible dysbiosis-mediated gut barrier impairment and bactericidal dysfunction	19
Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin	19
Defective AMPK regulation of cholesterol metabolism accelerates atherosclerosis by promoting HSPC mobilization and myelopoiesis	19
Nuclear Receptor CoRepressors, NCOR1 and SMRT, are required for maintaining systemic metabolic homeostasis	19
Insulin-sensitizing effects of vitamin D repletion mediated by adipocyte vitamin D receptor: Studies in humans and mice	19
Translating glucose tolerance data from mice to humans: Insights from stable isotope labelled glucose tolerance tests	19
Deletion of intestinal epithelial AMP-activated protein kinase alters distal colon permeability but not glucose homeostasis	19
Conditional gene targeting using UCP1-Cre mice directly targets the central nervous system beyond thermogenic adipose tissues	19
Chronic hyperinsulinemia promotes human hepatocyte senescence	19
Effects of ambient temperatures between 5 and 35 °C on energy balance, body mass and body composition in mice	19
Indoleamine 2,3-dioxygenase mediates the therapeutic effects of adipose-derived stromal/stem cells in experimental periodontitis by modulating macrophages through the kynurenine-AhR-NRF2 pathway	19
Crosstalk between the muscular estrogen receptor α and BDNF/TrkB signaling alleviates metabolic syndrome via 7,8-dihydroxyflavone in female mice	19
Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial–mesenchymal transition in diabetes	19
Diminished ketone interconversion, hepatic TCA cycle flux, and glucose production in D-β-hydroxybutyrate dehydrogenase hepatocyte-deficient mice	18
Function of the endolysosomal network in cholesterol homeostasis and metabolic-associated fatty liver disease (MAFLD)	18
A low-carbohydrate diet induces hepatic insulin resistance and metabolic associated fatty liver disease in mice	18
Dual specificity phosphatase 1 attenuates inflammation-induced cardiomyopathy by improving mitophagy and mitochondrial metabolism	18
Moderate SIRT1 overexpression protects against brown adipose tissue inflammation	18
Key features of inhibitor binding to the human mitochondrial pyruvate carrier hetero-dimer	18
HSP60 reduction protects against diet-induced obesity by modulating energy metabolism in adipose tissue	17
Histone deacetylase 5 regulates interleukin 6 secretion and insulin action in skeletal muscle	17
An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation	17
Monitoring and modelling the dynamics of the cellular glycolysis pathway: A review and future perspectives	17
Adipocyte integrin-linked kinase plays a key role in the development of diet-induced adipose insulin resistance in male mice	17
The metabolic syndrome, thiazolidinediones, and implications for intersection of chronic and inflammatory disease	17
Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion	17
Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction	17
Centrally circulating α-klotho inversely correlates with human obesity and modulates arcuate cell populations in mice	17
Plasma triacylglycerols are biomarkers of β-cell function in mice and humans	17
Autocrine negative feedback regulation of lipolysis through sensing of NEFAs by FFAR4/GPR120 in WAT	17
FOXO1 inhibition synergizes with FGF21 to normalize glucose control in diabetic mice	17
BBSome ablation in SF1 neurons causes obesity without comorbidities	17
Combined genetic deletion of GDF15 and FGF21 has modest effects on body weight, hepatic steatosis and insulin resistance in high fat fed mice	17
Notum deacylates octanoylated ghrelin	17
SERPINA3C ameliorates adipose tissue inflammation through the Cathepsin G/Integrin/AKT pathway	17
Enzymatic approaches for profiling cytosine methylation and hydroxymethylation	16
Small intestinal taurochenodeoxycholic acid-FXR axis alters local nutrient-sensing glucoregulatory pathways in rats	16
Novel thiazolidinedione analog reduces a negative impact on bone and mesenchymal stem cell properties in obese mice compared to classical thiazolidinediones	16
Loss of chemerin triggers bone remodeling in vivo and in vitro	16
Neuronal miR-29a protects from obesity in adult mice	16
Pharmacological FGF21 signals to glutamatergic neurons to enhance leptin action and lower body weight during obesity	16
The absence of hepatic glucose-6 phosphatase/ChREBP couple is incompatible with survival in mice	16
Insulin: A pacesetter for the shape of modern biomedical science and the Nobel Prize	16
White adipose remodeling during browning in mice involves YBX1 to drive thermogenic commitment	16
Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2α-dependent mechanism	16
Sensory neurons derived from diabetic rats exhibit deficits in functional glycolysis and ATP that are ameliorated by IGF-1	16
Histone H3K9 butyrylation is regulated by dietary fat and stress via an Acyl-CoA dehydrogenase short chain-dependent mechanism	16
Results from three phase 1 trials of NNC9204-1177, a glucagon/GLP-1 receptor co-agonist: Effects on weight loss and safety in adults with overweight or obesity	16
N-acylsphingosine amidohydrolase 1 promotes melanoma growth and metastasis by suppressing peroxisome biogenesis-induced ROS production	16
Physical exercise shapes the mouse brain epigenome	16
Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle	16
Non-alcoholic fatty liver disease is characterised by a reduced polyunsaturated fatty acid transport via free fatty acids and high-density lipoproteins (HDL)	16