Molecular Metabolism

Article	Citations
10 years of Molecular Metabolism	370
Loss of mitochondrial aconitase promotes colorectal cancer progression via SCD1-mediated lipid remodeling	259
GPSM1 in POMC neurons impairs brown adipose tissue thermogenesis and provokes diet-induced obesity	213
Hepatic regulator of G protein signaling 14 ameliorates NAFLD through activating cAMP-AMPK signaling by targeting Giα1/3	212
Neuronal miR-29a protects from obesity in adult mice	205
Acute inhibition of hunger-sensing AgRP neurons promotes context-specific learning in mice	194
TGF-β antagonism synergizes with PPARγ agonism to reduce fibrosis and enhance beige adipogenesis	182
Nutrient control of splice site selection contributes to methionine addiction of cancer	155
Depletion of pyruvate kinase (PK) activity causes glycolytic intermediate imbalances and reveals a PK-TXNIP regulatory axis	145
Reprogramming hormone-sensitive prostate cancer to a lethal neuroendocrine cancer lineage by mitochondrial pyruvate carrier (MPC)	143
Beta-hydroxybutyrate dampens adipose progenitors’ profibrotic activation through canonical Tgfβ signaling and non-canonical ZFP36-dependent mechanisms	143
Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions	142
Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction	140
Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis via β-Klotho and perilipin 2	139
Physical training reduces cell senescence and associated insulin resistance in skeletal muscle	136
Dysregulated systemic metabolism in a Down syndrome mouse model	127
Genome-wide meta-analysis of 92 cardiometabolic protein serum levels	112
Endothelial TrkA coordinates vascularization and innervation in thermogenic adipose tissue and can be targeted to control metabolism	112
Deletion of the mitochondrial calcium uniporter in adipose tissue promotes energy expenditure and alleviates diet-induced obesity	105
Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice	85
Peroxiredoxin 2 regulates DAF-16/FOXO mediated mitochondrial remodelling in response to exercise that is disrupted in ageing	84
Roux-en-Y gastric bypass contributes to weight loss-independent improvement in hypothalamic inflammation and leptin sensitivity through gut-microglia-neuron-crosstalk	84
Aregs-IGFBP3-mediated SMC-like cells apoptosis impairs beige adipocytes formation in aged mice	82
KBP-066A, a long-acting dual amylin and calcitonin receptor agonist, induces weight loss and improves glycemic control in obese and diabetic rats	82
Exercise-induced specialized proresolving mediators stimulate AMPK phosphorylation to promote mitochondrial respiration in macrophages	81

Declining muscle NAD+ in a hyperandrogenism PCOS mouse model: Possible role in metabolic dysregulation	80
From type 1 diabetes biology to therapy: The Human Islet Research Network	71
Endothelial BBSome is essential for vascular, metabolic, and retinal functions	70
Roles for Prlhr/GPR10 and Npffr2/GPR74 in feeding responses to PrRP	68
TGR5 receptors in SF1-expressing neurons of the ventromedial hypothalamus regulate glucose homeostasis	67
Bioenergetic adaptations of small intestinal epithelial cells reduce cell differentiation enhancing intestinal permeability in obese mice	67
Daily running enhances molecular and physiological circadian rhythms in skeletal muscle	66
Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signaling	62
Hemostatic alterations linked to body fat distribution, fatty liver, and insulin resistance	61
The physiology of experimental overfeeding in animals	61
Ketogenic diets composed of long-chain and medium-chain fatty acids induce cardiac fibrosis in mice	59
Deletion of intestinal epithelial AMP-activated protein kinase alters distal colon permeability but not glucose homeostasis	54
Emerging molecular technologies for light-mediated modulation of pancreatic beta-cell function	54
GLP-1 physiology informs the pharmacotherapy of obesity	53
The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR	53
Hindbrain REV-ERB nuclear receptors regulate sensitivity to diet-induced obesity and brown adipose tissue pathophysiology	51
Leveraging GPCR signaling in thermogenic fat to counteract metabolic diseases	51
NFE2L1-mediated proteasome function protects from ferroptosis	51
High-fat diet feeding disrupts the coupling of thermoregulation to energy homeostasis	51
Deletion of ABCB10 in beta-cells protects from high-fat diet induced insulin resistance	51
Dietary PUFAs drive diverse system-level changes in lipid metabolism	51
VMHdm/cSF-1 neuronal circuits regulate skeletal muscle PGC1-α via the sympathoadrenal drive	51
Mitochondrial protein deacetylation by SIRT3 in osteoclasts promotes bone resorption with aging in female mice	50
Corrigendum to “Adipocyte-specific FXR-deficiency protects adipose tissue from oxidative stress and insulin resistance and improves glucose homeostasis” [Mol Metab 69 (2023) 1–13]	49
EndoC-βH5 cells are storable and ready-to-use human pancreatic beta cells with physiological insulin secretion	48
Myeloid cell-specific Irf5 deficiency stabilizes atherosclerotic plaques in Apoe mice	48
Carboxylesterase 2a deletion provokes hepatic steatosis and insulin resistance in mice involving impaired diacylglycerol and lysophosphatidylcholine catabolism	48
Genetic disruption of the Gipr in Apoe−/− mice promotes atherosclerosis	48
Apolipoprotein A-IV is induced by high-fat diets and mediates positive effects on glucose and lipid metabolism	47
Nuclear receptors and transcriptional regulation in non-alcoholic fatty liver disease	47
Tumoral acidosis promotes adipose tissue depletion by fostering adipocyte lipolysis	46
Skeletal muscle BMAL1 is necessary for transcriptional adaptation of local and peripheral tissues in response to endurance exercise training	46
Isoxanthohumol improves obesity and glucose metabolism via inhibiting intestinal lipid absorption with a bloom of Akkermansia muciniphila in mice	46
Skeletal muscle undergoes fiber type metabolic switch without myosin heavy chain switch in response to defective fatty acid oxidation	46
Selective adipocyte loss of Angiopoietin-2 prompts female-specific obesity and metabolic syndrome	45
Validation of Mct8/Oatp1c1 dKO mice as a model organism for the Allan-Herndon-Dudley Syndrome	45
Editorial Board, cover figure description and credits	44
LGR4 is essential for maintaining β-cell homeostasis through suppression of RANK	43
A Cre-driver rat model for anatomical and functional analysis of glucagon (Gcg)-expressing cells in the brain and periphery	43
Survivin is essential for thermogenic program and metabolic homeostasis in mice	43
Permanent neonatal diabetes-causing insulin mutations have dominant negative effects on beta cell identity	43
Sestrin2 maintains hepatic immune homeostasis and redox balance partially via inhibiting RIPK3-mediated necroptosis in metabolic dysfunction-associated steatohepatitis	42
miR-10a regulates cell death and inflammation in adipose tissue of male mice with diet-induced obesity	42
MicroRNAs in non-alcoholic fatty liver disease: Progress and perspectives	41
Impacts of essential amino acids on energy balance	41
Linking metabolism and histone acetylation dynamics by integrated metabolic flux analysis of Acetyl-CoA and histone acetylation sites	40
Hypothalamic TTF-1 orchestrates the sensitivity of leptin	39
Alpha-melanocyte-stimulating hormone contributes to an anti-inflammatory response to lipopolysaccharide	39
Hepatic ketone body regulation of renal gluconeogenesis	38
Loss of epidermal glucocorticoid receptor protects against whole body metabolic dysfunction upon chronic corticosterone treatment	38

Editorial Board, cover figure description and credits	37
Picalm, a novel regulator of GLUT4-trafficking in adipose tissue	37
Editorial Board, cover figure description and credits	36
Editorial Board, cover figure description and credits	36
Pregnane X receptor activation remodels glucose metabolism to promote NAFLD development in obese mice	35
Metabolic profiling of single cells by exploiting NADH and FAD fluorescence via flow cytometry	35
Targeting the cytoplasmic polyadenylation element-binding protein CPEB4 protects against diet-induced obesity and microbiome dysbiosis	35
Effects of curtailed sleep on cardiac stress biomarkers following high-intensity exercise	35
NPY derived from AGRP neurons controls feeding via Y1 and energy expenditure and food foraging behaviour via Y2 signalling	35
Hepatocyte-specific O-GlcNAc transferase downregulation ameliorates nonalcoholic steatohepatitis by improving mitochondrial function	35
TFEB deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality	33
Challenges in tackling energy expenditure as obesity therapy: From preclinical models to clinical application	33
TCF7 is not essential for glucose homeostasis in mice	33
Hypothalamic free fatty acid receptor-1 regulates whole-body energy balance	33
Notum deacylates octanoylated ghrelin	32
Reversing Pdgfrβ signaling restores metabolically active beige adipocytes by alleviating ILC2 suppression in aged and obese mice	32
Deficiency of the mitochondrial transporter SLC25A47 minimally impacts hepatic lipid metabolism in fasted and diet-induced obese mice	32
Adaptive gene expression of alternative splicing variants of PGC-1α regulates whole-body energy metabolism	31
Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits adipocyte differentiation and thermogenesis	31
Dietary Advanced Glycation End products interacting with the intestinal epithelium: What do we really know?	31
miR-126 contributes to the epigenetic signature of diabetic vascular smooth muscle and enhances antirestenosis effects of Kv1.3 blockers	30
Intestinal gluconeogenesis controls the neonatal development of hypothalamic feeding circuits	30
Selective release of gastrointestinal hormones induced by an orally active GPR39 agonist	30
Insulin: A pacesetter for the shape of modern biomedical science and the Nobel Prize	30
Glucagon-like peptide-2 pharmacotherapy activates hepatic Farnesoid X receptor-signaling to attenuate resection-associated bile acid loss in mice	29
Glycerol-3-phosphate phosphatase operates a glycerol shunt in pancreatic β-cells that controls insulin secretion and metabolic stress	29
Decoding the immune dance: Unraveling the interplay between beta cells and type 1 diabetes	29
Iron aggravates hepatic insulin resistance in the absence of inflammation in a novel db/db mouse model with iron overload	29
Chronic cAMP activation induces adipocyte browning through discordant biphasic remodeling of transcriptome and chromatin accessibility	29
Chronic hyperinsulinemia promotes human hepatocyte senescence	29
PAQR9 regulates hepatic ketogenesis and fatty acid oxidation during fasting by modulating protein stability of PPARα	29
Comparative analysis of oral and intraperitoneal glucose tolerance tests in mice	28
Dissecting a disynaptic central amygdala-parasubthalamic nucleus neural circuit that mediates cholecystokinin-induced eating suppression	28
Cardiovascular protection by SGLT2 inhibitors – Do anti-inflammatory mechanisms play a role?	28
Free fatty acid receptor 1 stimulates cAMP production and gut hormone secretion through Gq-mediated activation of adenylate cyclase 2	28
Maresin 1 activates brown adipose tissue and promotes browning of white adipose tissue in mice	28
Multiple antisense oligonucleotides targeted against monoacylglycerol acyltransferase 1 (Mogat1) improve glucose metabolism independently of Mogat1	27
ROCK1 regulates insulin secretion from β-cells	27
Targeting hepatic oxidative stress rescues bone loss in liver fibrosis	27
Arginine deprivation/citrulline augmentation with ADI-PEG20 as novel therapy for complications in type 2 diabetes	27
A novel long non-coding RNA connects obesity to impaired adipocyte function	27
TMEM135 deficiency improves hepatic steatosis by suppressing CD36 in a SIRT1-dependent manner	27
Peptidylglycine alpha-amidating monooxygenase is important in mice for beta-cell cilia formation and insulin secretion but promotes diabetes risk through beta-cell independent mechanisms.	27
Insulin regulates human pancreatic endocrine cell differentiation in vitro	26
The homeodomain transcription factor Six3 regulates hypothalamic Pomc expression and its absence from POMC neurons induces hyperphagia and mild obesity in male mice	26
Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin	26
Crosstalk between TM4SF5 and GLUT8 regulates fructose metabolism in hepatic steatosis	26
Hepatic glucokinase regulatory protein and carbohydrate response element binding protein attenuation reduce de novo lipogenesis but do not mitigate intrahepatic triglyceride accumulation in Aldob defi	26
Exercise-induced methylation of the Serhl2 promoter and implication for lipid metabolism in rat skeletal muscle	26
New dawn for cancer cell death: Emerging role of lipid metabolism	25
What is a β cell? – Chapter I in the Human Islet Research Network (HIRN) review series	25
Glucose-induced insulin secretion in isolated human islets: Does it truly reflect β-cell function in vivo?	25
A low-carbohydrate diet induces hepatic insulin resistance and metabolic associated fatty liver disease in mice	25
Pharmacological FGF21 signals to glutamatergic neurons to enhance leptin action and lower body weight during obesity	25
Hepatic ChREBP orchestrates intrahepatic carbohydrate metabolism to limit hepatic glucose 6-phosphate and glycogen accumulation in a mouse model for acute Glycogen Storage Disease type Ib	24
An efficient AAV vector system of Rec2 serotype for intravenous injection to study metabolism in brown adipocytes in vivo	24
Editorial Board, cover figure description and credits	24
The role of intestinal microbiota in physiologic and body compositional changes that accompany CLA-mediated weight loss in obese mice	24
Epigenetic regulation of IPF fibroblast phenotype by glutaminolysis	24
Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction	24
Dysfunction of Akt/FoxO3a/Atg7 regulatory loop magnifies obesity-regulated muscular mass decline	24
ACC1 is a dual metabolic-epigenetic regulator of Treg stability and immune tolerance	24
Ablation of ORMDL3 impairs adipose tissue thermogenesis and insulin sensitivity by increasing ceramide generation	23
Corrigendum to “Results from three phase 1 trials of NNC9204-1177, a glucagon/GLP-1 receptor co-agonist: effects on weight loss and safety in adults with overweight or obesity” [Mol Metab 78 (2023) 10	23
Insulin resistance per se drives early and reversible dysbiosis-mediated gut barrier impairment and bactericidal dysfunction	23
The minor allele of the CREBRF rs373863828 p.R457Q coding variant is associated with reduced levels of myostatin in males: Implications for body composition	23
Osmoadaptive GLP-1R signalling in hypothalamic neurones inhibits antidiuretic hormone synthesis and release	23
Cannabinoid type-1 receptors in CaMKII neurons drive impulsivity in pathological eating behavior	23
Corrigendum to “Sema7A protects against high-fat diet-induced obesity and hepatic steatosis by regulating adipo/lipogenesis” [Mol Metab. 70 (2023) 101698]∗	23
Hypoxia inducible factor-dependent upregulation of Agrp in glomus type I cells of the carotid body	23
Neuropeptide Y1 receptor antagonism protects β-cells and improves glycemic control in type 2 diabetes	22
Stress kinases in the development of liver steatosis and hepatocellular carcinoma	22
Non-alcoholic fatty liver disease is characterised by a reduced polyunsaturated fatty acid transport via free fatty acids and high-density lipoproteins (HDL)	22
Median eminence myelin continuously turns over in adult mice	22
Effects of chronic high fat diet on mediobasal hypothalamic satiety neuron function in POMC-Cre mice	22
Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation	22
Structural principles of insulin formulation and analog design: A century of innovation	22
Toward modeling metabolic state from single-cell transcriptomics	22
Ablation of glucokinase-expressing tanycytes impacts energy balance and increases adiposity in mice	22
Macrophages on the run: Exercise balances macrophage polarization for improved health	22

Sensory neurons derived from diabetic rats exhibit deficits in functional glycolysis and ATP that are ameliorated by IGF-1	22
Editorial Board, cover figure description and credits	21
Intrinsic cardiorespiratory fitness modulates clinical and molecular response to caloric restriction	21
SF1-specific deletion of the energy sensor AMPKγ2 induces obesity	21
Dietary protein defends lean mass and maintains the metabolic benefits of glucagon receptor agonism in mice	21
Ube4A maintains metabolic homeostasis and facilitates insulin signaling in vivo	21
Editorial Board, cover figure description and credits	21
Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity	21
Gsα-dependent signaling is required for postnatal establishment of a functional β-cell mass	21
The novel adrenergic agonist ATR-127 targets skeletal muscle and brown adipose tissue to tackle diabesity and steatohepatitis	21
Intestinal SEC16B modulates obesity by regulating chylomicron metabolism	21
Editorial Board, cover figure description and credits	21
Mutations in DNAJC19 cause altered mitochondrial structure and increased mitochondrial respiration in human iPSC-derived cardiomyocytes	21
Elevation of hypothalamic ketone bodies induces a decrease in energy expenditures and an increase risk of metabolic disorder	21
Partial agonism improves the anti-hyperglycaemic efficacy of an oxyntomodulin-derived GLP-1R/GCGR co-agonist	21
Corrigendum to single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice - Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-ex	20
Adipocyte Septin-7 attenuates obesogenic adipogenesis and promotes lipolysis to prevent obesity	20
Human ACVR1C missense variants that correlate with altered body fat distribution produce metabolic alterations of graded severity in knock-in mutant mice	20
Gemigliptin, a DPP4 inhibitor, ameliorates nonalcoholic steatohepatitis through AMP-activated protein kinase-independent and ULK1-mediated autophagy	20
Tubular mitochondrial pyruvate carrier disruption elicits redox adaptations that protect from acute kidney injury	20
Spatiotemporal regulation of GIPR signaling impacts glucose homeostasis as revealed in studies of a common GIPR variant	19
NAFLD - A rising metabolic disease	19
Serum amyloid A1 exacerbates hepatic steatosis via TLR4-mediated NF-κB signaling pathway	19
Semaglutide and bariatric surgery induce distinct changes in the composition of mouse white adipose tissue	19
Mapping the transcriptional landscape of human white and brown adipogenesis using single-nuclei RNA-seq	19
Microbiota and body weight control: Weight watchers within?	19
Vertical sleeve gastrectomy increases duodenal Lactobacillus spp. richness associated with the activation of intestinal HIF2α signaling and metabolic benefits	19
The hepatocyte IKK:NF-κB axis promotes liver steatosis by stimulating de novo lipogenesis and cholesterol synthesis	19
Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network	19
Glycolysis maintains AMPK activation in sorafenib-induced Warburg effect	19
Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice	19
A caveolin-1 dependent glucose-6-phosphatase trafficking contributes to hepatic glucose production	18
Increased susceptibility to diet-induced obesity in female mice impairs ovarian steroidogenesis: The role of elevated leptin signalling on nodal activity inhibition in theca cells	18
Brain insulin signaling suppresses lipolysis in the absence of peripheral insulin receptors and requires the MAPK pathway	18
Exercise-induced hypothalamic neuroplasticity: Implications for energy and glucose metabolism	18
Hepatic retinol dehydrogenase 11 dampens stress associated with the maintenance of cellular cholesterol levels	18
Editorial Board, cover figure description and credits	18
LRP1 in GABAergic neurons is a key link between obesity and memory function	18
Corrigendum to “Beta cell specific cannabinoid 1 receptor deletion counteracts progression to hyperglycemia in non-obese diabetic mice” [Mol Metab 82 (2024 April) 101906]	18
De novo labeling and trafficking of individual lipid species in live cells	18
Mesenchymal-specific Alms1 knockout in mice recapitulates metabolic features of Alström syndrome	18
NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition	18
The mitochondrial pyruvate carrier regulates adipose glucose partitioning in female mice	18
Regulation of body weight: Lessons learned from bariatric surgery	17
In celebration of a century with insulin – Update of insulin gene mutations in diabetes	17
Endothelial arginase 2 mediates retinal ischemia/reperfusion injury by inducing mitochondrial dysfunction	17
The gut-brain axis mediates bacterial driven modulation of reward signaling	17
Calcium/calmodulin-dependent protein kinase kinase 2 regulates hepatic fuel metabolism	17
Effects of metformin on the gut microbiota: A systematic review	17
Hepatic Activin E mediates liver-adipose inter-organ communication, suppressing adipose lipolysis in response to elevated serum fatty acids	17
Autophagic signaling promotes systems-wide remodeling in skeletal muscle upon oncometabolic stress by D2-HG	17
Discovery of ecnoglutide – A novel, long-acting, cAMP-biased glucagon-like peptide-1 (GLP-1) analog	17
Nipsnap1—A regulatory factor required for long-term maintenance of non-shivering thermogenesis	17
Dorsolateral septum GLP-1R neurons regulate feeding via lateral hypothalamic projections	17
Neuronal loss of TRPM8 leads to obesity and glucose intolerance in male mice	17
Hmgcs2-mediated ketogenesis modulates high-fat diet-induced hepatosteatosis	17
Calponin 2 harnesses metabolic reprogramming to determine kidney fibrosis	17
Loss of lysosomal acid lipase results in mitochondrial dysfunction and fiber switch in skeletal muscles of mice	17
Cyp2c-deficiency depletes muricholic acids and protects against high-fat diet-induced obesity in male mice but promotes liver damage	17
Roles and therapeutic targeting of ceramide metabolism in cancer	17
Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists	17
An early, reversible cholesterolgenic etiology of diet-induced insulin resistance	17
Feeding desensitizes A1 adenosine receptors in adipose through FOXO1-mediated transcriptional regulation	16
Phosphomimetic Dicer S1016E triggers a switch to glutamine metabolism in gemcitabine-resistant pancreatic cancer	16
Need for speed: Human fast-twitch mitochondria favor power over efficiency	16
Regulation of hepatic circadian metabolism by the E3 ubiquitin ligase HRD1-controlled CREBH/PPARα transcriptional program	16
Identification of novel GPCR partners of the central melanocortin signaling	16
Apolipoprotein C3 and circulating mediators of preadipocyte proliferation in states of lipodystrophy	16
Protection of pancreatic islets from oxidative cell death by a peripherally-active morphinan with increased drug safety	16
LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue	16
Corrigendum to “Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells” [Mol Metab 2016 May; 5 (5): 366–378]	16
Pioneer factor Foxa2 enables ligand-dependent activation of type II nuclear receptors FXR and LXRα	16
Extracellular vesicles in β cell biology: Role of lipids in vesicle biogenesis, cargo, and intercellular signaling	16
Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function	16
Intestinal Acyl-CoA synthetase 5 (ACSL5) deficiency potentiates postprandial GLP-1 & PYY secretion, reduces food intake, and protects against diet-induced obesity	16
Editorial Board, cover figure description and credits	16
The neglected PCK1/glucagon (inter)action in nutrient homeostasis beyond gluconeogenesis: Disease pathogenesis and treatment	16