Molecular Metabolism

Article	Citations
GLP-1 receptor agonists in the treatment of type 2 diabetes – state-of-the-art	498
Monocarboxylate transporters in cancer	327
Ketogenic diet in the treatment of cancer – Where do we stand?	233
Metabolic dysfunction in polycystic ovary syndrome: Pathogenic role of androgen excess and potential therapeutic strategies	208
Diabetes, infection risk and COVID-19	200
Dysregulated lipid metabolism links NAFLD to cardiovascular disease	190
Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer	189
Metabolic-associated fatty liver disease and lipoprotein metabolism	182
Compartmentalised acyl-CoA metabolism and roles in chromatin regulation	142
Glucagon-like peptide-1 receptor co-agonists for treating metabolic disease	141
A guide to understanding endoplasmic reticulum stress in metabolic disorders	131
Nonalcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans	130
Mechanisms of insulin resistance related to white, beige, and brown adipocytes	124
Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street	120
Formate metabolism in health and disease	111
The melanocortin pathway and energy homeostasis: From discovery to obesity therapy	110
GLP-1 physiology informs the pharmacotherapy of obesity	109
Role of NAD+ in regulating cellular and metabolic signaling pathways	102
Insulin action at a molecular level – 100 years of progress	99
A non-proliferative role of pyrimidine metabolism in cancer	98
Hepatic lipid droplets: A balancing act between energy storage and metabolic dysfunction in NAFLD	96
Hepatokines and metabolism: Deciphering communication from the liver	93
Adapt and conquer: Metabolic flexibility in cancer growth, invasion and evasion	90
Metabolic drivers of non-alcoholic fatty liver disease	90
Insulin-like growth factors: Ligands, binding proteins, and receptors	87

The brain as an insulin-sensitive metabolic organ	83
Imaging biomarkers of NAFLD, NASH, and fibrosis	81
Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis	71
Genetic and epigenetic factors determining NAFLD risk	68
Glucagon acutely regulates hepatic amino acid catabolism and the effect may be disturbed by steatosis	66
Single-cell transcriptomics of human islet ontogeny defines the molecular basis of β-cell dedifferentiation in T2D	63
Overexpression of the vitamin D receptor (VDR) induces skeletal muscle hypertrophy	59
GLP-1 improves the supportive ability of astrocytes to neurons by promoting aerobic glycolysis in Alzheimer's disease	58
Beta cell identity changes with mild hyperglycemia: Implications for function, growth, and vulnerability	57
Understanding insulin and its receptor from their three-dimensional structures	57
CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing	56
Two genomes, one cell: Mitochondrial-nuclear coordination via epigenetic pathways	55
Targeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms	55
Sodium-glucose co-transporter2 expression and inflammatory activity in diabetic atherosclerotic plaques: Effects of sodium-glucose co-transporter2 inhibitor treatment	54
Nicotinamide N-methyltransferase: At the crossroads between cellular metabolism and epigenetic regulation	54
Ferroptosis and ferritinophagy in diabetes complications	54
Wnt/β-catenin signaling regulates adipose tissue lipogenesis and adipocyte-specific loss is rigorously defended by neighboring stromal-vascular cells	52
Mitochondrial oxidative function in NAFLD: Friend or foe?	50
Infusion of donor feces affects the gut–brain axis in humans with metabolic syndrome	50
Irisin: Still chasing shadows	50
Exploring the therapeutic potential of mitochondrial uncouplers in cancer	49
Partial leptin deficiency confers resistance to diet-induced obesity in mice	48
Targeting extracellular nutrient dependencies of cancer cells	47
PPARγ and PPARα synergize to induce robust browning of white fat in vivo	47
Interactions between metabolism and chromatin in plant models	46
Suppressing adipocyte inflammation promotes insulin resistance in mice	45
Iron aggravates hepatic insulin resistance in the absence of inflammation in a novel db/db mouse model with iron overload	44
Cross-omics analysis revealed gut microbiome-related metabolic pathways underlying atherosclerosis development after antibiotics treatment	44
Human islets contain a subpopulation of glucagon-like peptide-1 secreting α cells that is increased in type 2 diabetes	43
Therapeutic potential of mitochondrial uncouplers for the treatment of metabolic associated fatty liver disease and NASH	42
Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction	42
AhR activation defends gut barrier integrity against damage occurring in obesity	42
Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice	40
Sperm histone H3 lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunction	39
Maternal obesity causes fetal hypothalamic insulin resistance and disrupts development of hypothalamic feeding pathways	39
Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high-fat diet	38
Role and mechanism of ferroptosis in neurological diseases	38
A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing	38
Chromatin-remodeling links metabolic signaling to gene expression	37
Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists	37
FGF19 and FGF21: In NASH we trust	37
Intestine-selective reduction of Gcg expression reveals the importance of the distal gut for GLP-1 secretion	37
LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue	37
Non-alcoholic fatty liver disease and steatohepatitis: State of the art on effective therapeutics based on the gold standard method for diagnosis	37
The taming of PARP1 and its impact on NAD+ metabolism	36
Impacts of essential amino acids on energy balance	35
Dopamine D2 receptor agonist, bromocriptine, remodels adipose tissue dopaminergic signalling and upregulates catabolic pathways, improving metabolic profile in type 2 diabetes	35
Chromatin dynamics and histone modifications in intestinal microbiota-host crosstalk	35
Hepatocyte miR-34a is a key regulator in the development and progression of non-alcoholic fatty liver disease	35
Cholesterol 25-hydroxylase (CH25H) as a promoter of adipose tissue inflammation in obesity and diabetes	35

Fasting induces ANGPTL4 and reduces LPL activity in human adipose tissue	35
Testosterone metabolites differentially regulate obesogenesis and fat distribution	34
LKB1 deficiency-induced metabolic reprogramming in tumorigenesis and non-neoplastic diseases	34
Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior	34
Regulation of hepatic glutamine metabolism by miR-122	33
Insulin resistance is mechanistically linked to hepatic mitochondrial remodeling in non-alcoholic fatty liver disease	33
Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo	33
Adipocyte-specific Beclin1 deletion impairs lipolysis and mitochondrial integrity in adipose tissue	33
Interplay between RNA-binding protein HuR and Nox4 as a novel therapeutic target in diabetic kidney disease	33
Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise	33
Disconnect between signalling potency and in vivo efficacy of pharmacokinetically optimised biased glucagon-like peptide-1 receptor agonists	32
LDLR inhibition promotes hepatocellular carcinoma proliferation and metastasis by elevating intracellular cholesterol synthesis through the MEK/ERK signaling pathway	32
De novo discovery of metabolic heterogeneity with immunophenotype-guided imaging mass spectrometry	32
Dietary ω3-and ω6-Polyunsaturated fatty acids reconstitute fertility of Juvenile and adult Fads2-Deficient mice	30
Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function	30
MicroRNAs in non-alcoholic fatty liver disease: Progress and perspectives	30
Cyb5r3 links FoxO1-dependent mitochondrial dysfunction with β-cell failure	30
Skeletal muscle in healthy humans exhibits a day-night rhythm in lipid metabolism	29
An accomplice more than a mere victim: The impact of β-cell ER stress on type 1 diabetes pathogenesis	29
Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat	29
Purification of pancreatic endocrine subsets reveals increased iron metabolism in beta cells	29
Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis	29
Exercise of high intensity ameliorates hepatic inflammation and the progression of NASH	29
The gut–brain axis: Identifying new therapeutic approaches for type 2 diabetes, obesity, and related disorders	29
Review: Glucose-sensitive insulin	29
High-fat diet induces time-dependent synaptic plasticity of the lateral hypothalamus	28
Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and diurnal rhythms	28
Insulin's actions on vascular tissues: Physiological effects and pathophysiological contributions to vascular complications of diabetes	28
Prior exercise in humans redistributes intramuscular GLUT4 and enhances insulin-stimulated sarcolemmal and endosomal GLUT4 translocation	27
NF-κB signaling in tanycytes mediates inflammation-induced anorexia	27
Gut microbiota impairs insulin clearance in obese mice	27
Organelle transporters and inter-organelle communication as drivers of metabolic regulation and cellular homeostasis	27
Hypoxia-inducible lipid droplet-associated induces DGAT1 and promotes lipid storage in hepatocytes	27
Growth differentiation factor 15 as a potential therapeutic for treating obesity	27
Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity	27
Mitochondrial function in intestinal epithelium homeostasis and modulation in diet-induced obesity	27
Hmgcs2-mediated ketogenesis modulates high-fat diet-induced hepatosteatosis	27
The hepatocyte IKK:NF-κB axis promotes liver steatosis by stimulating de novo lipogenesis and cholesterol synthesis	27
P2Y2R contributes to the development of diabetic nephropathy by inhibiting autophagy response	27
Ovarian cancer modulates the immunosuppressive function of CD11b+Gr1+ myeloid cells via glutamine metabolism	26
Nuclear receptors and transcriptional regulation in non-alcoholic fatty liver disease	26
Toward modeling metabolic state from single-cell transcriptomics	26
Challenges in tackling energy expenditure as obesity therapy: From preclinical models to clinical application	26
Metabolic insights from a GHSR-A203E mutant mouse model	26
RNA m6A reader IMP2/IGF2BP2 promotes pancreatic β-cell proliferation and insulin secretion by enhancing PDX1 expression	26
Ceramides are necessary and sufficient for diet-induced impairment of thermogenic adipocytes	26
“A LEAP 2 conclusions? Targeting the ghrelin system to treat obesity and diabetes”	26
Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance	25
Microbiota and body weight control: Weight watchers within?	25
Glucose-induced insulin secretion in isolated human islets: Does it truly reflect β-cell function in vivo?	25
ApoA-1 improves glucose tolerance by increasing glucose uptake into heart and skeletal muscle independently of AMPKα2	25
Mitochondrial AIF loss causes metabolic reprogramming, caspase-independent cell death blockade, embryonic lethality, and perinatal hydrocephalus	25
Novel noncoding RNA CircPTK2 regulates lipolysis and adipogenesis in cachexia	25
Reappraisal of the optimal fasting time for insulin tolerance tests in mice	25
Comparative analysis of oral and intraperitoneal glucose tolerance tests in mice	25
ATF4-mediated transcriptional regulation protects against β-cell loss during endoplasmic reticulum stress in a mouse model	25
CD81 marks immature and dedifferentiated pancreatic β-cells	25
PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments	25
β-catenin regulates muscle glucose transport via actin remodelling and M-cadherin binding	24
SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans	24
Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN	24
Dpp4+ interstitial progenitor cells contribute to basal and high fat diet-induced adipogenesis	24
Whole-brain activation signatures of weight-lowering drugs	24
Baricitinib counteracts metaflammation, thus protecting against diet-induced metabolic abnormalities in mice	23
Update on the effects of energy metabolism in bone marrow mesenchymal stem cells differentiation	23
Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling	23
Reversal of diet-induced hepatic steatosis by peripheral CB1 receptor blockade in mice is p53/miRNA-22/SIRT1/PPARα dependent	23
Genetic activation of α-cell glucokinase in mice causes enhanced glucose-suppression of glucagon secretion during normal and diabetic states	23
Cardiovascular protection by SGLT2 inhibitors – Do anti-inflammatory mechanisms play a role?	23
Prolonged fasting drives a program of metabolic inflammation in human adipose tissue	23
Aster-B coordinates with Arf1 to regulate mitochondrial cholesterol transport	23
Skeletal muscle undergoes fiber type metabolic switch without myosin heavy chain switch in response to defective fatty acid oxidation	22
Farnesoid X receptor contributes to body weight-independent improvements in glycemic control after Roux-en-Y gastric bypass surgery in diet-induced obese mice	22
Stress kinases in the development of liver steatosis and hepatocellular carcinoma	22
Tirzepatide induces a thermogenic-like amino acid signature in brown adipose tissue	22
The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis	22
Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions	22
Day-night rhythm of skeletal muscle metabolism is disturbed in older, metabolically compromised individuals	22
Regulation of inflammation in diabetes: From genetics to epigenomics evidence	22
Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation	22

Estrogen receptor-α in female skeletal muscle is not required for regulation of muscle insulin sensitivity and mitochondrial regulation	21
Sirt6 in pro-opiomelanocortin neurons controls energy metabolism by modulating leptin signaling	21
Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis	21
p21 induces a senescence program and skeletal muscle dysfunction	21
BI 456906: Discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy	21
Exposure to low-dose perfluorooctanoic acid promotes hepatic steatosis and disrupts the hepatic transcriptome in mice	21
Muscle NAD+ depletion and Serpina3n as molecular determinants of murine cancer cachexia—the effects of blocking myostatin and activins	21
Genetic loss of AMPK-glycogen binding destabilises AMPK and disrupts metabolism	21
Chronic inflammation and the hallmarks of aging	21
New dawn for cancer cell death: Emerging role of lipid metabolism	21
Metformin-induced reductions in tumor growth involves modulation of the gut microbiome	21
The role of exercise-induced peripheral factors in sleep regulation	20
Serum integrative omics reveals the landscape of human diabetic kidney disease	20
URAT1-selective inhibition ameliorates insulin resistance by attenuating diet-induced hepatic steatosis and brown adipose tissue whitening in mice	20
Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network	20
Loss of mitochondrial aconitase promotes colorectal cancer progression via SCD1-mediated lipid remodeling	20
Neuroanatomical organization and functional roles of PVN MC4R pathways in physiological and behavioral regulations	20
PPG neurons in the nucleus of the solitary tract modulate heart rate but do not mediate GLP-1 receptor agonist-induced tachycardia in mice	20
Peroxisomal regulation of energy homeostasis: Effect on obesity and related metabolic disorders	20
Early induction of hepatic deiodinase type 1 inhibits hepatosteatosis during NAFLD progression	20
Nutrient sensing in the nucleus of the solitary tract mediates non-aversive suppression of feeding via inhibition of AgRP neurons	20
Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression	20
LANCL1 binds abscisic acid and stimulates glucose transport and mitochondrial respiration in muscle cells via the AMPK/PGC-1α/Sirt1 pathway	20
In celebration of a century with insulin – Update of insulin gene mutations in diabetes	20
17β-estradiol promotes acute refeeding in hungry mice via membrane-initiated ERα signaling	20
Free fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice	20
Roles of bone-derived hormones in type 2 diabetes and cardiovascular pathophysiology	19
Roux-en-Y gastric bypass contributes to weight loss-independent improvement in hypothalamic inflammation and leptin sensitivity through gut-microglia-neuron-crosstalk	19
A Neural basis for Octanoic acid regulation of energy balance	19
Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity	19
Early life lessons: The lasting effects of germline epigenetic information on organismal development	19
Functional changes of the liver in the absence of growth hormone (GH) action – Proteomic and metabolomic insights from a GH receptor deficient pig model	19
Serum amyloid A1 exacerbates hepatic steatosis via TLR4-mediated NF-κB signaling pathway	19
A novel lncRNA RP11-386G11.10 reprograms lipid metabolism to promote hepatocellular carcinoma progression	19
What is a β cell? – Chapter I in the Human Islet Research Network (HIRN) review series	19
GLP-1 and hunger modulate incentive motivation depending on insulin sensitivity in humans	19
Upregulated ethanolamine phospholipid synthesis via selenoprotein I is required for effective metabolic reprogramming during T cell activation	18
Insulin and obesity transform hypothalamic-pituitary-adrenal axis stemness and function in a hyperactive state	18
Adaptive thermogenesis in brown adipose tissue involves activation of pannexin-1 channels	18
Parathyroid hormone (PTH) regulation of metabolic homeostasis: An old dog teaches us new tricks	18
Hypothalamic Pomc expression restricted to GABAergic neurons suppresses Npy overexpression and restores food intake in obese mice	18
Tryptophan metabolism is a physiological integrator regulating circadian rhythms	18
Role of ATP-binding cassette transporter A1 in suppressing lipid accumulation by glucagon-like peptide-1 agonist in hepatocytes	18
Mono and dual agonists of the amylin, calcitonin, and CGRP receptors and their potential in metabolic diseases	18
Sensory neurons expressing calcitonin gene-related peptide α regulate adaptive thermogenesis and diet-induced obesity	18
Disabling MNK protein kinases promotes oxidative metabolism and protects against diet-induced obesity	18
Osteocalcin and vascular function: is there a cross-talk?	17
Centrally circulating α-klotho inversely correlates with human obesity and modulates arcuate cell populations in mice	17
Cigarette smoke exposure impairs β-cell function through activation of oxidative stress and ceramide accumulation	17
Time and metabolic state-dependent effects of GLP-1R agonists on NPY/AgRP and POMC neuronal activity in vivo	17
Deletion of intestinal epithelial AMP-activated protein kinase alters distal colon permeability but not glucose homeostasis	17
Short-term inhibition of autophagy benefits pancreatic β-cells by augmenting ether lipids and peroxisomal function, and by countering depletion of n-3 polyunsaturated fatty acids after fat-feeding	17
Notum deacylates octanoylated ghrelin	17
Targeting cellular senescence in metabolic disease	17
Diminished ketone interconversion, hepatic TCA cycle flux, and glucose production in D-β-hydroxybutyrate dehydrogenase hepatocyte-deficient mice	17
Plasma triacylglycerols are biomarkers of β-cell function in mice and humans	17
Type 2 diabetes subgroups and potential medication strategies in relation to effects on insulin resistance and beta-cell function: A step toward personalised diabetes treatment?	17
Adipose tissue macrophages: Regulators of adipose tissue immunometabolism during obesity	17
Moderate SIRT1 overexpression protects against brown adipose tissue inflammation	17
Intestinal stem cell-derived enteroids from morbidly obese patients preserve obesity-related phenotypes: Elevated glucose absorption and gluconeogenesis	17
Brown adipocyte-specific knockout of Bmal1 causes mild but significant thermogenesis impairment in mice	17
Endothelial arginase 2 mediates retinal ischemia/reperfusion injury by inducing mitochondrial dysfunction	17
Glucocorticoids coordinate macrophage metabolism through the regulation of the tricarboxylic acid cycle	17
Wntless regulates lipogenic gene expression in adipocytes and protects against diet-induced metabolic dysfunction	17
Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin	17
Interaction of glucose sensing and leptin action in the brain	16
TFEB deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality	16
Autocrine negative feedback regulation of lipolysis through sensing of NEFAs by FFAR4/GPR120 in WAT	16
Adipocytes fail to maintain cellular identity during obesity due to reduced PPARγ activity and elevated TGFβ-SMAD signaling	16
FGF15/19 is required for adipose tissue plasticity in response to thermogenic adaptations	16
Metabolic transcriptional memory	16
Characterizing pancreatic β-cell heterogeneity in the streptozotocin model by single-cell transcriptomic analysis	16
Insulin: A pacesetter for the shape of modern biomedical science and the Nobel Prize	16
Regulation of body weight: Lessons learned from bariatric surgery	16
The effects of housing density on mouse thermal physiology depend on sex and ambient temperature	16
Hypothalamic POMC deficiency increases circulating adiponectin despite obesity	16
Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR–v-ATPase axis	16
Increased glycolysis affects β-cell function and identity in aging and diabetes	16
MBOAT7-driven phosphatidylinositol remodeling promotes the progression of clear cell renal carcinoma	16
Translating glucose tolerance data from mice to humans: Insights from stable isotope labelled glucose tolerance tests	16
Insulin resistance per se drives early and reversible dysbiosis-mediated gut barrier impairment and bactericidal dysfunction	16
Crosstalk between the muscular estrogen receptor α and BDNF/TrkB signaling alleviates metabolic syndrome via 7,8-dihydroxyflavone in female mice	15
Mitochondrial pyruvate carrier inhibition initiates metabolic crosstalk to stimulate branched chain amino acid catabolism	15
Multiple metabolic pathways fuel the truncated tricarboxylic acid cycle of the prostate to sustain constant citrate production and secretion	15
Metabolic therapy and bioenergetic analysis: The missing piece of the puzzle	15
Function of the endolysosomal network in cholesterol homeostasis and metabolic-associated fatty liver disease (MAFLD)	15
Refeeding activates neurons in the dorsomedial hypothalamus to inhibit food intake and promote positive valence	15
KBP-066A, a long-acting dual amylin and calcitonin receptor agonist, induces weight loss and improves glycemic control in obese and diabetic rats	15
Histone deacetylase 5 regulates interleukin 6 secretion and insulin action in skeletal muscle	15
BBSome ablation in SF1 neurons causes obesity without comorbidities	15
Insulin-sensitizing effects of vitamin D repletion mediated by adipocyte vitamin D receptor: Studies in humans and mice	15
The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR	15
FOXO1 inhibition synergizes with FGF21 to normalize glucose control in diabetic mice	15
BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice	15
Ablation of glucokinase-expressing tanycytes impacts energy balance and increases adiposity in mice	15