OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Bone Oncology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Using β-Elemene to reduce stemness and drug resistance in osteosarcoma: A focus on the AKT/FOXO1 signaling pathway and immune modulation	86
Fracture risk in breast cancer: Does obesity have an effect? A scoping review	48
Role of the osteocyte in bone metastasis – The importance of networking	44
Senescence in the bone marrow microenvironment: A driver in development of therapy-related myeloid neoplasms	41
Impact of adjuvant imatinib on bone and muscle density in patients with resected gastrointestinal stromal tumors	35
Is surgery without curettage effective for periacetabular Metastasis? Insights from a survival study of 93 patients	32
Improved osteosarcoma survival with addition of mifamurtide to conventional chemotherapy – Observational prospective single institution analysis	30
YBX1-interacting small RNAs and RUNX2 can be blocked in primary bone cancer using CADD522	24
Study of imaging changes following preoperative denosumab for giant cell tumor of bone	20
Automated measurement of lumbar pedicle screw parameters using deep learning algorithm on preoperative CT scans	20
#21. PD-1 blockade induces bone loss and reduces bone strength in a breast cancer bone metastasis model	19
#37. Lactate-GPR81 signaling in acute myeloid leukemia (AML) contributes to bone marrow microenvironment dysfunction, macrophage polarization, and leukemia cell growth	19
#43. Long-chain acyl-CoA synthetases support multiple myeloma cell proliferation, survival and mitochondrial function	19
#9. Inhibition of the fatty acid binding proteins (FABPs) in myeloma cells modifies their lipid composition	19
#45. Fatty acid binding proteins may modulate myeloma in Fabp4/5 double knockout mouse	19
CDK4/6 inhibitor and doxorubicin synergistically inhibit breast cancer bone metastasis and enhance T-cell targeted therapy	17
#33. PTHrP biological domains differentially regulate breast tumor intracrine signaling independent of nuclear localization	17
#15. Single-cell discovery and multi-omic characterization of therapeutic targets in multiple myeloma	17
#42. Local and systemic effects of Dickkopf-1 during breast cancer progression by limiting NK cell-mediated killing	17
Preventing osteolytic lesions and osteomyelitis in multiple myeloma	16
#7. Downstream effects of Gli2 targeting on tumor-immune cell crosstalk in bone metastatic breast cancer	16
Lipid metabolic reprogramming and associated ferroptosis in osteosarcoma: From molecular mechanisms to potential targets	15
What to choose in bone tumour resections? Patient specific instrumentation versus surgical navigation: a systematic review	15
Molecular pathological insights into tumorigenesis and progression of giant cell tumor of bone	14
Automatic classification of spinal osteosarcoma and giant cell tumor of bone using optimized DenseNet	13

Prosthesis or osteosynthesis for the treatment of a pathological hip fracture? A nationwide registry-based cohort study	13
Prognostic factors and survival of patients undergoing surgical intervention for breast cancer bone metastases	13
Incidence, Risk Factors, and Survival of Bone Metastases and Skeletal-Related Events in Melanoma Patients: A Systematic Review and Quality Assessment of 29 Studies	13
Long non-coding RNA KRT8P41/miR-193a-3p/FUBP1 axis modulates the proliferation and invasion of chordoma cells	13
Surgical management and outcome of Extra-adrenal myelolipomas at unusual locations: A report of 11 cases in a single center	12
Hsa_circ_0010220 regulates miR-198/Syntaxin 6 axis to promote osteosarcoma progression	12
Serum total periostin is an independent marker of overall survival in bone metastases of lung adenocarcinoma	12
Bones and guts – Why the microbiome matters	11
Deep learning-based magnetic resonance imaging of the spine in the diagnosis and physiological evaluation of spinal metastases	11
Macrophage heterogeneity in bone metastasis	11
Experience with denosumab (XGEVA®) for prevention of skeletal-related events in the 10 years after approval	10
Bone tumor examination based on FCNN-4s and CRF fine segmentation fusion algorithm	10
From bimodal to unimodal: The transformed incidence of osteosarcoma in the United States	10
Postoperative outcomes of subaxial cervical spine metastasis: Comparison among the anterior, posterior, and combined approaches	10
Emerging roles for stromal cells in bone metastasis	10
Chinese expert consensus on the diagnosis and clinical management of medication-related osteonecrosis of the jaw	9
Adamantinoma: A review of the current literature	9
The impact of androgen deprivation therapy on bone microarchitecture in men with prostate cancer: A longitudinal observational study (The ANTELOPE Study)	9
Targeting ferroptosis in osteosarcoma	9
Targeting transforming growth factor beta signaling in metastatic osteosarcoma	9
Langerhans Cell Histiocytosis: A Population-based Study of Anatomical Distribution and Treatment Patterns	9
Epidemiology and detection of cement leakage in patients with spine metastases treated with percutaneous vertebroplasty: A 10-year observational study	9
Erratum to “Identifying biomolecules and constructing a prognostic risk prediction model for recurrence in osteosarcoma” [J. Bone Oncol. 26 (2021) 100331]	9
MAT2A inhibits the ferroptosis in osteosarcoma progression regulated by miR-26b-5p	9
Sensory nerves: A driver of the vicious cycle in bone metastasis?	9
Focal adhesion kinase inhibitors prevent osteoblast mineralization in part due to suppression of Akt-mediated stabilization of osterix	8
Bone niches in the regulation of tumour cell dormancy	8
Novel_circ_003686 regulates the osteogenic differentiation of MSCs in patients with myeloma bone disease through miR-142-5p/IGF1 axis	8
Pexmetinib suppresses osteoclast formation and breast cancer induced osteolysis via P38/STAT3 signal pathway	8
Phenotypic plasticity – Implications for tumours in bone	8
Radiomics model based on MRI to differentiate spinal multiple myeloma from metastases: A two-center study	8
Establishment and characterization of a highly metastatic human osteosarcoma cell line from osteosarcoma lung metastases	8
N-cadherin in osteolineage cells modulates stromal support of tumor growth	8
Adipocytes and metabolism: Contributions to multiple myeloma	8
Impact of quantitative CT texture analysis on the outcome of CT-guided bone biopsy	8
Luteolin attenuates the chemoresistance of osteosarcoma through inhibiting the PTN/β-catenin/MDR1 signaling axis by upregulating miR-384	8
Circ_0051079 silencing inhibits the malignant phenotypes of osteosarcoma cells by the TRIM66/Wnt/β-catenin pathway in a miR-625-5p-dependent manner	7
Comparative analysis of aggressiveness in giant cell tumor of bone between upper and lower extremities: A systematic review and meta-analysis	7
Adjuvant bisphosphonate use in patients with early stage breast cancer: Patient perspectives on treatment acceptability and potential de-escalation	7
Bone-derived excess TGF-ß release is associated with cognitive dysfunction due to oxidation of RyR, Ca2+ leak and mitochondrial dysfunction	7
The patterns of distant metastasis and prognostic factors in patients with primary metastatic Ewing sarcoma of the bone	7
Urinary biomarkers in metastatic bone pain: Results from a multicentre randomized trial of ibandronate compared to single dose radiotherapy for localized metastatic bone pain in prostate cancer (RIB)	7
Therapeutic approaches in patients with bone metastasis due to endometrial carcinoma – A systematic review	7
A novel adjunctive diagnostic method for bone cancer: Osteosarcoma cell segmentation based on Twin Swin Transformer with multi-scale feature fusion	7
Does liquid nitrogen recycled autograft for treatment of bone sarcoma impact local recurrence rate? A systematic review	7
#36. Novel therapeutic development with serine biosynthesis inhibition and molecularly targeted drugs against the aggressive osteosarcoma	7
The role and mechanism of JAK2/STAT3 signaling pathway regulated by m6A methyltransferase KIAA1429 in osteosarcoma	7
Use of FVB Myc-CaP cells as an immune competent, androgen receptor positive, mouse model of prostate cancer bone metastasis	7
State-of-the-art of minimally invasive treatments of bone metastases	7
Deep bone oncology Diagnostics: Computed tomography based Machine learning for detection of bone tumors from breast cancer metastasis	7

#35. Defining short-form RON mediated anti-tumor immunity in breast cancer bone metastasis	7
#5. Activating RET mutations in medullary thyroid cancer cells promotes osteoblastic bone metastasis by inhibiting osteoclastogenesis and stimulating osteoblast activity	6
A phase IB and randomised phase IIA trial of CApecitabine plus Radium-223 (Xofigo™) in breast cancer patients with BONe metastases: CARBON trial results	6
Silencing of circCYP51A1 represses cell progression and glycolysis by regulating miR-490-3p/KLF12 axis in osteosarcoma under hypoxia	6
The role of intraoperative cell salvage for musculoskeletal sarcoma surgery	6
#17. Evolution of epidemiology of bone metastasis in France: A rising issue	6
#3. IL-17A supports osteoblasts to become cancer-associated fibroblasts in breast cancer bone metastases	6
Prevalence of low bone mineral density and risk of fractures in osteosarcoma and Ewing’s sarcoma survivors: A scoping review	6
LINC00482 sponged miR-2467-3p to promote bone metastasis of prostate cancer through activating Wnt/β-catenin signaling pathway	6
#10. Investigating the role of non-canonical Hedgehog signaling in paclitaxel-resistant bone- metastatic breast cancer	6
Contrast-enhanced magnetic resonance image segmentation based on improved U-Net and Inception-ResNet in the diagnosis of spinal metastases	6
In vitro three-dimensional cell cultures for bone sarcomas	6
Current strategies for the treatment of solitary and aneurysmal bone cysts: A review of the literature	6