FEBS Open Bio

Article	Citations
Analgesic effects of nerve growth factor‐directed monoclonal antibody on diabetic neuralgia in an animal model	79
Issue Information	55
Targeted recombination of homologous chromosomes using CRISPR‐Cas9	51
Issue Information	46
Teaching, research or balanced? An exploration of the experiences of biomedical scientists working in UK medical schools	43
Comparative transcriptomics of the Djungarian hamster hypothalamus during short photoperiod acclimation and spontaneous torpor	38
Nitric oxide inhibits endothelial cell apoptosis by inhibiting cysteine‐dependent SOD1 monomerization	37
Prognostic significance of the rhoGTPase RHOVand its role in tumor immune cell infiltration: a comprehensive pan‐cancer analysis	37
	37
Membrane‐acting biomimetic peptoids against visceral leishmaniasis	34
Regorafenib as a potential drug for severe COVID‐19: inhibition of inflammasome activation in mice	33
Dexamethasone induces p21cip1/waf1 expression via FoxO3a independently of the Lamin A/C‐HDAC2 interaction in Ataxia Telangiectasia	33
Lewis fucose is a key moiety for the recognition of histo‐blood group antigens by GI.9 norovirus, as revealed by structural analysis	33
2‐dodecyl‐6‐methoxycyclohexa‐2,5‐diene‐1,4‐dione mediates the effect of ROS‐enhanced PI3K/Akt/mTOR pathway on autophagy in breast cancer	30
Antitubercular potential and pH‐driven mode of action of salicylic acid derivatives	30
RETRACTION: LKB1 Suppresses Androgen Synthesis in a Mouse Model of Hyperandrogenism via IGF‐1 Signaling	30
Suppression of intrahepatic cholangiocarcinoma cell growth by SKI via upregulation of the CDK inhibitor p21	28
Structural analysis of an Asterias rubens peptide indicates the presence of a disulfide‐directed β‐hairpin fold	28
Anti‐inflammatory properties of ophioglonin derived from the fern Ophioglossum vulgatum L. via inactivating NF‐κB and MAPK signaling pathways	26
Interaction of RECQL4 with poly(ADP‐ribose) is critical for the DNA double‐strand break response in human cells	26
KCS1 and VIP1, the genes encoding yeast phosphoinositol pyrophosphate synthases, are required for Ca2+‐mediated response to dimethylsulfoxide (DMSO<	25
Posters Annex	25
A mouse model of lung cancer induced via intranasal injection for anticancer drug screening and evaluation of pathology	24
Accumulation of amyloid beta (Aβ) and amyloid precursor protein (APP) in tumors formed by a mouse xenograft model of inflammatory breast cancer	24
Glucose 6‐phosphate dehydrogenase variants increase NADPH pools for yeast isoprenoid production	24

Issue Information	23
GRK5‐mediated inflammation and fibrosis exert cardioprotective effects during the acute phase of myocardial infarction	23
Characterization and comparison of recombinant full‐length ursine and human sex hormone‐binding globulin	23
Lipoxin A4 protects primary spinal cord neurons from Erastin‐induced ferroptosis by activating the Akt/Nrf2/HO‐1 signaling pathway	23
CCR4‐IL2 bispecific immunotoxin is more effective than brentuximab for targeted therapy of cutaneous T‐cell lymphoma in a mouse CTCL model	23
SV40 T antigen helicase domain regions responsible for oligomerisation regulate Okazaki fragment synthesis initiation	22
High growth hormone serum partially protects mice against Trypanosoma cruzi infection	22
Cantharidin downregulates PSD1 expression and inhibits autophagic flux in yeast cells	22
	22
Withdrawal: Urinary exosomal tRNA‐derived small RNA signatures as a predictive biomarker in lung cancer	21
	20
Talks	20
Viral and cellular translation during SARS‐CoV‐2 infection	19
The spike glycoprotein of highly pathogenic human coronaviruses: structural insights for understanding infection, evolution and inhibition	19
Endoplasmic reticulum stress inhibits 3D Matrigel‐induced vasculogenic mimicry of breast cancer cells via TGF‐β1/Smad2/3 and β‐catenin signaling	19
Synergistic antibacterial activity of baicalin in combination with oxacillin sodium against methicillin‐resistant Staphylococcus aureus	19
Triosephosphate isomerase of Streptococcus pneumoniae is released extracellularly by autolysis and binds to host plasminogen to promote its activation	19
Nanoparticles of folic acid‐methyl‐β‐cyclodextrin (FA‐MβCD)/adamantane‐albumin exhibit enhanced antitumor activity compared with FA‐MβCD alone	19
Lactate administration does not affect denervation‐induced loss of mitochondrial content and muscle mass in mice	18
Phenotypical and biochemical characterization of murine psoriasiform and fibrotic skin disease models in Stabilin‐deficient mice	18
YAP‐TEAD inhibition is associated with upregulation of an androgen receptor mediated transcription program providing therapeutic escape	18
DDR2 signaling and mechanosensing orchestrate neuroblastoma cell fate through different transcriptome mechanisms	18
Retraction statement: Ubiquitin ligase SMURF1 functions as a prognostic marker and promotes growth and metastasis of clear cell renal cell carcinoma	17
Fibroblast growth factor 2 acts as an upstream regulator of inhibition of pulmonary fibroblast activation	17
A potential tumor suppressor role of PLK2 in glioblastoma	17
Characterization of the promoter region of the murine Catsper2 gene	16
Enhancing transporter activity in heterologous expression systems with SAHA: a 2500‐times more potent and odorless alternative to butyrate	16
Science students' perspectives on how to decrease the stigma of failure	16
Development and single‐particle analysis of hybrid extracellular vesicles fused with liposomes using viral fusogenic proteins	16
	15
Metabolic changes induced by DNA damage in Ramos cells: exploring the role of mTORC1 complex	15
Metabolic reprogramming heterogeneity in chronic kidney disease	15
	15
Issue Information	15
The mTOR–lysosome axis at the centre of ageing	15
Extracellular RNA transfer from non‐malignant human cholangiocytes can promote cholangiocarcinoma growth	15
Serving the scientific community: FEBS Open Bio in 2024	15
MTHFD2 promotes ovarian cancer growth and metastasis via activation of the STAT3 signaling pathway	15
Reviewers acknowledgement	14
Multi‐omics‐based analysis of high grade serous ovarian cancer subtypes reveals distinct molecular processes linked to patient prognosis	14
The composition of the lung microbiome differs between patients with dermatomyositis and rheumatoid arthritis associated with interstitial lung disease	14
A framework for decolonising and diversifying biomedical sciences curricula: rediscovery, representation and readiness	14
Elevated mRNA expression and defective processing of cathepsin D in HeLa cells lacking the mannose 6‐phosphate pathway	14
Dapagliflozin reverses the imbalance of T helper 17 and T regulatory cells by inhibiting SGK1 in a mouse model of diabetic kidney disease	13
Ezetimibe inhibits the migration and invasion of triple‐negative breast cancer cells by targeting TGFβ2 and EMT	13
RETRACTION: Bach2 overexpression represses Th9 cell differentiation by suppressing IRF4 expression in systemic lupus erythematosus	13
IFNγ induces Bcl3 expression by JAK1/STAT1/p65 signaling, resulting in increased IL‐8 expression in ovarian cancer cells	13
Cell culture and genetic transfection methods for the Japanese scallop, Patinopecten yessoensis	13
Glycolipids in Parkinson's disease: beyond neuronal function	13
Ceruloplasmin overexpression is associated with oncogenic pathways and poorer survival rates in clear‐cell renal cell carcinoma	13

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions	13
EvoProDom: evolutionary modeling of protein families by assessing translocations of protein domains	13
Overexpression of BcERF3 increases the biosynthesis of saikosaponins in Bupleurum chinense	13
Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction	12
Multiple time‐dependent pathophysiological changes in a rabbit model of high‐fat diet‐induced hyperlipidemia	12
Prediction of chaperonin GroE substrates using small structural patterns of proteins	12
Bovine natural antibody IgM inhibits the binding of human norovirus protruding domain to its HBGA receptors	12
The mitochondrial fission factor FIS1 promotes stemness of human lung cancer stem cells via mitophagy	12
Structural investigations on the mitochondrial uncouplers niclosamide and FCCP	12
Evaluation of binding activities of a putative lipoprotein LIC_13355 of Leptospira spp.	12
Issue Information	12
	11
Selective proteasome degradation of C‐terminally‐truncated human WFS1 in pancreatic beta cells	11
Identification and functional comparison of novel alternatively spliced isoforms of human YAP	11
	11
A systems biological analysis of the ATF4‐GADD34‐CHOP regulatory triangle upon endoplasmic reticulum stress	10
DDX3 participates in miRNA biogenesis and RNA interference through translational control of PACT and interaction with AGO2	10
The crystal structure of methanogen McrD, a methyl‐coenzyme M reductase‐associated protein	10
Long noncoding RNAMEG3 inhibits oral squamous cell carcinoma progression via GATA3	10
Myeloperoxidase inhibition protects bone marrow mononuclear cells from DNA damage induced by the TOP2 poison anti‐cancer drug etoposide	10
In vitro and in vivo safety studies indicate that R15, a synthetic polyarginine peptide, could safely reverse the effects of unfractionated heparin	10
‘Let's work together to pass medical school’: a qualitative study of medical student attitudes to teamwork, competition and collaboration	10
Lkb1 loss in regulatory T cells leads to dysregulation of hematopoietic stem cell expansion and differentiation in bone marrow	10
Reduced FRG1 expression promotes angiogenesis via activation of the FGF2‐mediated ERK/AKT pathway	10
FAM136A depletion induces mitochondrial stress and reduces mitochondrial membrane potential and ATP production	10
HELQ deficiency impairs the induction of primordial germ cell‐like cells	10
An open chat with… Johannes Herrmann	10
Cancer cells forgo translating mRNA transcribed from genes of nonspecialized tasks	10
Phosphorylation of RyR2 Ser‐2814 by CaMKII mediates β1‐adrenergic stress induced Ca2+‐leak from the sarcoplasmic reticulum	10
Polysaccharide utilization loci encoded DUF1735 likely functions as membrane‐bound spacer for carbohydrate active enzymes	10
Alfaxalone does not have long‐term effects on goldfish pyramidal neuron action potential properties or GABAA receptor currents	10
FSH enhances the inflammatory response of macrophages in the knee joint possibly through the NFκB pathway	10
Histone demethylase KDM6B inhibits breast cancer metastasis by regulating Wnt/β‐catenin signaling	10
Chloroplast genomes of two Pueraria DC. species: sequencing, comparative analysis and molecular marker development	10
Ensuring image integrity in the digital age	10
	9
Entering the second decade: FEBS Open Bio in 2022	9
A comparative study of mouse bone marrow mesenchymal stem cells isolated using three easy‐to‐perform approaches	9
The anti‐cancer effect of epigallocatechin‐3‐O‐gallate against multiple myeloma cells is potentiated by 5,7‐dimethoxyflavone	9
	9
Issue Information	8
Plasmalogen‐rich foods promote the formation of cubic membranes in amoeba Chaos under stress conditions	8
Strengthening the bond with the scientific community: FEBS Open Bio in 2025	8
Intermittent induction of LEA peptide by lactose enhances the expression of insecticidal proteins in Bacillus thuringiensis	8
The first crystal structure of a family 45 glycoside hydrolase from a brown‐rot fungus, Gloeophyllum trabeumGtCel45A	8
Issue Information	8
Issue Information	8
Microglia heterogeneity in health and disease	8
Reviewers acknowledgement	8
Report on the FEBS‐IUBMB‐ENABLE 1st International Molecular Biosciences PhD and Postdoc Conference	8
Retraction: Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo	8
Identification of testicular cancer immune infiltrates and novel immune cell subtypes	8
Time‐dependent effects of hypoxia on cell metabolism, signaling, and iron homeostasis in the hematopoietic progenitor model KG1a	8
Erratum to: BAP1 promotes viability and migration of ECA109 cells through KLF5/CyclinD1/FGF‐BP1	8
Gene expression and characterization of clonally derived murine embryonic brown and brite adipocytes	8
Corrigendum to “Endoplasmic reticulum stress associated with lead (Pb)‐induced olfactory epithelium toxicity in an olfactory dark basal cell line” https://doi.org/10.1002/2211‐5463.13714	8
FEBS Open Bio: past, present and future	8
Cotton flower metabolites inhibit SARS‐CoV‐2 main protease	8
Oxidative stress in the tumor microenvironment in gastric cancer and its potential role in immunotherapy	8
NPC1 promotes the progression of hepatocellular carcinoma by mediating the accumulation of neutrophils into the tumor microenvironment	8
Cell‐specific genome‐scale metabolic modeling of SARS‐CoV‐2‐infected lung to identify antiviral enzymes	8
FLI1 mediates the selective expression of hypoxia‐inducible factor 1 target genes in endothelial cells under hypoxic conditions	8
C188‐9 reduces TGF‐β1‐induced fibroblast activation and alleviates ISO‐induced cardiac fibrosis in mice	8
On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469	7
Benefits of exercise on cognitive impairment in alcohol use disorder following alcohol withdrawal	7
Expression and purification of E140 protein antigen fragments of Plasmodium vivax and Plasmodium berghei for serological assays	7
Metallodrugs: an approach against invasion and metastasis in cancer treatment	7
Toll‐like receptor 9 signaling in chronic lymphocytic leukemia cell lines	7
Characterization of the complete chloroplast genome of Rhodiola sachalinensis and comparative analysis with its congeneric plants	7
The cytotoxic action of BCI is not dependent on its stated DUSP1 or DUSP6 targets in neuroblastoma cells	7
Optimization of a modeling platform to predict oncogenes from genome‐scale metabolic networks of non‐small‐cell lung cancers	7
The splicing factor DHX38/PRP16 is required for ovarian clear cell carcinoma tumorigenesis, as revealed by a CRISPR‐Cas9 screen	7
Mitochondrial complex IV defects induce metabolic and signaling perturbations that expose potential vulnerabilities in HCT116 cells	7
Revealing protein structures: crystallization of protein‐ligand complexes – co‐crystallization and crystal soaking	7
Ferritin heavy chain (FTH1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c‐MYC	7
Issue Information	7
Liraglutide enhances the effect of checkpoint blockade in lung and liver cancers through the inhibition of neutrophil extracellular traps	7
The cryo‐EM structure of full‐length RAD52 protein contains an undecameric ring	7
Histone chaperone‐mediated co‐expression assembly of tetrasomes and nucleosomes	7
Activation of ERK–Drp1 signaling promotes hypoxia‐induced Aβ accumulation by upregulating mitochondrial fission and BACE1 activity	7

Development of a fully human anti‐GITR antibody with potent antitumor activity using H2L2 mice	7
Pulmonary ACE2 expression in neonatal and adult rats	7
	7
Characterisation of a common hotspot variant in acute intermittent porphyria sheds light on the mechanism of hydroxymethylbilane synthase function	7
The interplay between pathogens and Atg8 family proteins: thousand‐faced interactions	6
	6
Development and validation of a four‐lipid metabolism gene signature for diagnosis of pancreatic cancer	6
Intracellular protein crystallization in living insect cells	6
Front Cover	6
A non‐fluorescent immunohistochemistry method for measuring autophagy flux using MAP1LC3/LC3 and SQSTM1 as core markers	6
Issue Information	6
Learning objectives: an epiphany	6
Biochemical characterization and gene structure analysis of the 24‐kDa glutathione transferase sigma from Taenia solium	6
Retraction statement: MicroRNA‐431 inhibits migration and invasion of hepatocellular carcinoma cells by targeting the ZEB1‐mediated epithelial–mesenchymal transition	6
RAB31 in glioma‐derived endothelial cells promotes glioma cell invasion via extracellular vesicle‐mediated enrichment of MYO1C	6
Issue Information	6
The miR‐223/nuclear factor I‐A axis regulates inflammation and cellular functions in intestinal tissues with necrotizing enterocolitis	6
The dynamics of cell death patterns and regeneration during acute liver injury in mice	6
Real‐world genomic landscape of colon and rectal cancer	6
Biological and clinical implications of metastasis‐associated circular RNAs in oesophageal squamous cell carcinoma	6
	6
	6
Overexpressed Smurf1 is degraded in glioblastoma cells through autophagy in a p62‐dependent manner	6
RETRACTION: MicroRNA‐498 Reduces the Proliferation and Invasion of Colorectal Cancer Cells via Targeting Bcl‐2	6
Talks	6
A brief overview of BNIP3L/NIX receptor‐mediated mitophagy	6
Expression of a Crry/p65 is reduced in acute lung injury induced by extracellular histones	6
Prognostic biomarker identification and tumor classification in breast cancer patients by methylation and transcriptome analysis	6
Talks	6
Acquired and intrinsic resistance to vemurafenib in BRAFV600E‐driven melanoma brain metastases	6
CDK5 interacts with MST2 and modulates the Hippo signalling pathway	6
Issue Information	6
Mutations in RPS19 may affect ribosome function and biogenesis in Diamond Blackfan anemia	6
Transcriptional repression shapes the identity and function of tissue macrophages	6
Retraction statement: miR‐944 inhibits metastasis of gastric cancer by preventing the epithelial–mesenchymal transition via MACC1/Met/AKT signaling	6
Nanoscale‐tipped wire array injections transfer DNA directly into brain cells ex vivo and in vivo	6
Tyr76 is essential for the cold adaptation of a class II glutaredoxin 4 with a heat‐labile structure from the Arctic bacteriumSphingomonassp.	6
Biochemical characterization of the human ubiquitous glucose‐6‐phosphatase in neutrophil granulocytes	5
On the design of a constitutively active peptide asparaginyl ligase for facile protein conjugation	5
Beta cell regeneration upon magainin and growth hormone treatment as a possible alternative to insulin therapy	5
CDX2 regulates interleukin‐33 gene expression in intestinal epithelial cells (LS174T)	5
Flow cytometric resolution of yeast is affected by enzymatic treatment and culture media	5
Structure prediction analysis of human core TIM23 complex reveals conservation of the protein translocation mechanism	5
MYPT1 inhibits the metastasis of renal clear cell carcinoma via the MAPK8/N‐cadherin pathway	5
Diacylglycerol kinase ζ interacts with sphingomyelin synthase 1 and sphingomyelin synthase‐related protein via different regions	5
Profiling of gut microbial dysbiosis in adults with myeloid leukemia	5
Crystal structure of a novel homodimeric l‐ribulose 3‐epimerase from Methylomonus sp.	5
On the difficulties of characterizing weak protein interactions that are critical for neurotransmitter release	5
Isolation and characterization of peritoneal microvascular pericytes	5
Intrabacterial lipid inclusion‐associated proteins: a core machinery conserved from saprophyte Actinobacteria to the human pathogen Mycobacterium tuberculosis	5
Knockdown of RNF6 inhibits HeLa cervical cancer cell growth via suppression of MAPK/ERK signaling	5
Externally added cystatin C reduces growth of A375 melanoma cells by increasing cell cycle time	5
Hesperidin enhances intestinal barrier function in Caco‐2 cell monolayers via AMPK‐mediated tight junction‐related proteins	5
Malus pumila Mill. cv Annurca apple extract might be therapeutically useful against oxidative stress and patterned hair loss	5
Biochemical and in silico identification of the active site and the catalytic mechanism of the circadian deadenylase HESPERIN	5
WDHD1 is over‐expressed in nasopharyngeal carcinoma and may control the expression of ITGAV	5
Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study	5
Alkane biosynthesis gene expression and its increased production in recombinant cyanobacteria	5
Development of a mouse embryonic stem cell model for investigating the functions of the linker histone H1‐4	5
Using a ‘Students as Partners’ model to develop an authentic assessment promoting employability skills in undergraduate life science education	5
HPV18 E6 inhibits α‐ketoglutarate‐induced pyroptosis of esophageal squamous cell carcinoma cells via the P53/MDH1/ROS/GSDMC pathway	5
Issue Information	5
	5
Tryptophan‐sensing receptor GPR142 expression levels are directly regulated by proinflammatory cytokines in ghrelin‐producing cells	5
Knockdown of TMEM160 leads to an increase in reactive oxygen species generation and the induction of the mitochondrial unfolded protein response	5
Inflammatory activation of endothelial cells increases glycolysis and oxygen consumption despite inhibiting cell proliferation	5
Establishment of a risk score model for bladder urothelial carcinoma based on energy metabolism‐related genes and their relationships with immune infiltration	5
Cordycepin inhibits cell senescence by ameliorating lysosomal dysfunction and inducing autophagy through the AMPK and mTOR–p70S6K pathway	5
Identification and analysis of short indels inducing exon extension/shrinkage events	5
Structures of distantly related interacting protein homologs are less divergent than non‐interacting homologs	4
Lipid dysmetabolism in ceruloplasmin‐deficient mice revealed both in vivo and ex vivo by MRI, MRS and NMR analyses	4
Obesity‐induced oxidative stress and mitochondrial dysfunction negatively affect sperm quality	4
Kinetic characterization of amino acid activation by aminoacyl‐tRNA synthetases using radiolabelled γ‐[32P]ATP	4
Overexpression of HPRT1 is associated with poor prognosis in head and neck squamous cell carcinoma	4
Comparative genome analysis of three classical E. coli cloning strains designed for blue/white selection: JM83, JM109 and XL1‐Blue	4
A novel plasmid‐based experimental system in Saccharomyces cerevisiae that enables the introduction of 10 different plasmids into cells	4
Stereospecificity of hydride transfer and molecular docking in FMN‐dependent NADH‐indigo reductase of Bacillus smithii	4
Abstracts	4
Retraction statement: microRNA‐497 inhibits cell proliferation and induces apoptosis by targeting YAP1 in human hepatocellular carcinoma	4
Titanium particles inhibit bone marrow mesenchymal stem cell osteogenic differentiation through the MAPK signaling pathway	4
Identification of crucial noncoding RNAs and mRNAs in hypertrophic scars via RNA sequencing	4
Hippocampal tau‐induced GRIN3A deficiency in Alzheimer's disease	4
Cylindracin, a Cys‐rich protein expressed in the fruiting body of Cyclocybe cylindracea, inhibits growth of filamentous fungi but not yeasts or bacteria	4
Cardiovascular risk of dietary trimethylamine oxide precursors and the therapeutic potential of resveratrol and its derivatives	4
Determination of the optimal connector length to enhance stability of backbone‐circularized granulocyte colony‐stimulating factor	4
ARL2 is required for homologous recombination repair and colon cancer stem cell survival	4
Issue Information	4
Improved strategy for jet‐in‐air cell sorting with high purity, yield, viability, and genome stability	4
	4
Peptide mimetic NC114 induces growth arrest by preventing PKCδ activation and FOXM1 nuclear translocation in colorectal cancer cells	4
Exploring gene regulatory interaction networks and predicting therapeutic molecules for hypopharyngeal cancer and EGFR‐mutated lung adenocarcinoma	4
Retraction statement: Shao, L., Zhang, X. and Yao, Q. (2020), The F‐box protein FBXO11 restrains hepatocellular carcinoma stemness via promotion of ubiquitin‐mediated degradation of Snail. FEBS Open B	4
Alcohol induces α2‐6sialo mucin O‐glycans that kill U937 macrophages mediated by sialic acid‐binding immunoglobulin‐like lectin 7 (Siglec 7)	4
Accumulation of TERT in mitochondria exerts two opposing effects on apoptosis	4
Withdrawal statement: [Liu, X., Qiao, L., Zhang, H., Zhang, C., Ding, R., Kang, J., Liu, Y., Lin, J. and Yan, X. (2023), Argonaute 2 regulates LPS‐induced inflammation in microglial BV2 cells by targe	4