FEBS Open Bio

Article	Citations
Issue Information	87
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2‐dodecyl‐6‐methoxycyclohexa‐2,5‐diene‐1,4‐dione mediates the effect of ROS‐enhanced PI3K/Akt/mTOR pathway on autophagy in breast cancer	55
Antitubercular potential and pH‐driven mode of action of salicylic acid derivatives	49
RETRACTION: LKB1 Suppresses Androgen Synthesis in a Mouse Model of Hyperandrogenism via IGF‐1 Signaling	48
Interaction of RECQL4 with poly(ADP‐ribose) is critical for the DNA double‐strand break response in human cells	42
Posters Annex	39
Glucose 6‐phosphate dehydrogenase variants increase NADPH pools for yeast isoprenoid production	38
Accumulation of amyloid beta (Aβ) and amyloid precursor protein (APP) in tumors formed by a mouse xenograft model of inflammatory breast cancer	38
Lewis fucose is a key moiety for the recognition of histo‐blood group antigens by GI.9 norovirus, as revealed by structural analysis	33
Suppression of intrahepatic cholangiocarcinoma cell growth by SKI via upregulation of the CDK inhibitor p21	32
Dexamethasone induces p21cip1/waf1 expression via FoxO3a independently of the Lamin A/C‐HDAC2 interaction in Ataxia Telangiectasia	31
Targeted recombination of homologous chromosomes using CRISPR‐Cas9	30
Structural analysis of an Asterias rubens peptide indicates the presence of a disulfide‐directed β‐hairpin fold	30
Analgesic effects of nerve growth factor‐directed monoclonal antibody on diabetic neuralgia in an animal model	30
Regorafenib as a potential drug for severe COVID‐19: inhibition of inflammasome activation in mice	29
Anti‐inflammatory properties of ophioglonin derived from the fern Ophioglossum vulgatum L. via inactivating NF‐κB and MAPK signaling pathways	28
Prognostic significance of the rhoGTPase RHOVand its role in tumor immune cell infiltration: a comprehensive pan‐cancer analysis	28
Comparative transcriptomics of the Djungarian hamster hypothalamus during short photoperiod acclimation and spontaneous torpor	27
Teaching, research or balanced? An exploration of the experiences of biomedical scientists working in UK medical schools	27
KCS1 and VIP1, the genes encoding yeast phosphoinositol pyrophosphate synthases, are required for Ca2+‐mediated response to dimethylsulfoxide (DMSO<	26
A mouse model of lung cancer induced via intranasal injection for anticancer drug screening and evaluation of pathology	26
Nitric oxide inhibits endothelial cell apoptosis by inhibiting cysteine‐dependent SOD1 monomerization	26
Membrane‐acting biomimetic peptoids against visceral leishmaniasis	24

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CCR4‐IL2 bispecific immunotoxin is more effective than brentuximab for targeted therapy of cutaneous T‐cell lymphoma in a mouse CTCL model	22
Withdrawal: Urinary exosomal tRNA‐derived small RNA signatures as a predictive biomarker in lung cancer	22
Talks	21
SV40 T antigen helicase domain regions responsible for oligomerisation regulate Okazaki fragment synthesis initiation	21
Characterization and comparison of recombinant full‐length ursine and human sex hormone‐binding globulin	21
Development and single‐particle analysis of hybrid extracellular vesicles fused with liposomes using viral fusogenic proteins	21
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Science students' perspectives on how to decrease the stigma of failure	21
Nanoparticles of folic acid‐methyl‐β‐cyclodextrin (FA‐MβCD)/adamantane‐albumin exhibit enhanced antitumor activity compared with FA‐MβCD alone	20
High growth hormone serum partially protects mice against Trypanosoma cruzi infection	20
Characterization of the promoter region of the murine Catsper2 gene	20
GRK5‐mediated inflammation and fibrosis exert cardioprotective effects during the acute phase of myocardial infarction	20
YAP‐TEAD inhibition is associated with upregulation of an androgen receptor mediated transcription program providing therapeutic escape	19
Phenotypical and biochemical characterization of murine psoriasiform and fibrotic skin disease models in Stabilin‐deficient mice	19
Cantharidin downregulates PSD1 expression and inhibits autophagic flux in yeast cells	18
Enhancing transporter activity in heterologous expression systems with SAHA: a 2500‐times more potent and odorless alternative to butyrate	18
Lactate administration does not affect denervation‐induced loss of mitochondrial content and muscle mass in mice	17
Metabolic reprogramming heterogeneity in chronic kidney disease	17
DDR2 signaling and mechanosensing orchestrate neuroblastoma cell fate through different transcriptome mechanisms	17
A potential tumor suppressor role of PLK2 in glioblastoma	16
The mTOR–lysosome axis at the centre of ageing	16
Retraction statement: Ubiquitin ligase SMURF1 functions as a prognostic marker and promotes growth and metastasis of clear cell renal cell carcinoma	16
Viral and cellular translation during SARS‐CoV‐2 infection	16
Synergistic antibacterial activity of baicalin in combination with oxacillin sodium against methicillin‐resistant Staphylococcus aureus	16
The spike glycoprotein of highly pathogenic human coronaviruses: structural insights for understanding infection, evolution and inhibition	16
The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise	15
Endoplasmic reticulum stress inhibits 3D Matrigel‐induced vasculogenic mimicry of breast cancer cells via TGF‐β1/Smad2/3 and β‐catenin signaling	15
Fibroblast growth factor 2 acts as an upstream regulator of inhibition of pulmonary fibroblast activation	15
MTHFD2 promotes ovarian cancer growth and metastasis via activation of the STAT3 signaling pathway	15
Triosephosphate isomerase of Streptococcus pneumoniae is released extracellularly by autolysis and binds to host plasminogen to promote its activation	15
Serving the scientific community: FEBS Open Bio in 2024	14
NMR screening of low molecular weight inhibitors targeting the papain‐like protease (PLPro) of SARS‐CoV‐2	14
Issue Information	14
The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity	14
IFNγ induces Bcl3 expression by JAK1/STAT1/p65 signaling, resulting in increased IL‐8 expression in ovarian cancer cells	13
Bovine natural antibody IgM inhibits the binding of human norovirus protruding domain to its HBGA receptors	13
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Multiple time‐dependent pathophysiological changes in a rabbit model of high‐fat diet‐induced hyperlipidemia	13
Ezetimibe inhibits the migration and invasion of triple‐negative breast cancer cells by targeting TGFβ2 and EMT	13
Reviewers acknowledgement	13
Metabolic changes induced by DNA damage in Ramos cells: exploring the role of mTORC1 complex	13
Overexpression of BcERF3 increases the biosynthesis of saikosaponins in Bupleurum chinense	12
EvoProDom: evolutionary modeling of protein families by assessing translocations of protein domains	12
Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction	12
Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions	12
A framework for decolonising and diversifying biomedical sciences curricula: rediscovery, representation and readiness	12
Evaluation of binding activities of a putative lipoprotein LIC_13355 of Leptospira spp.	12
Multi‐omics‐based analysis of high grade serous ovarian cancer subtypes reveals distinct molecular processes linked to patient prognosis	12
Extracellular RNA transfer from non‐malignant human cholangiocytes can promote cholangiocarcinoma growth	12

RETRACTION: Bach2 overexpression represses Th9 cell differentiation by suppressing IRF4 expression in systemic lupus erythematosus	12
The composition of the lung microbiome differs between patients with dermatomyositis and rheumatoid arthritis associated with interstitial lung disease	11
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Glycolipids in Parkinson's disease: beyond neuronal function	11
Ceruloplasmin overexpression is associated with oncogenic pathways and poorer survival rates in clear‐cell renal cell carcinoma	11
Structural investigations on the mitochondrial uncouplers niclosamide and FCCP	11
Selective proteasome degradation of C‐terminally‐truncated human WFS1 in pancreatic beta cells	10
Alfaxalone does not have long‐term effects on goldfish pyramidal neuron action potential properties or GABAA receptor currents	10
Polysaccharide utilization loci encoded DUF1735 likely functions as membrane‐bound spacer for carbohydrate active enzymes	10
Knockout of the mitoribosome rescue factors Ict1 or Mtrfr is viable in zebrafish but not mice: compensatory mechanisms underlying each factor's loss	10
A systems biological analysis of the ATF4‐GADD34‐CHOP regulatory triangle upon endoplasmic reticulum stress	10
The crystal structure of methanogen McrD, a methyl‐coenzyme M reductase‐associated protein	10
DDX3 participates in miRNA biogenesis and RNA interference through translational control of PACT and interaction with AGO2	10
Prediction of chaperonin GroE substrates using small structural patterns of proteins	10
HELQ deficiency impairs the induction of primordial germ cell‐like cells	10
An open chat with… Johannes Herrmann	10
Earthing effects on mitochondrial function: ATP production and ROS generation	10
Reduced FRG1 expression promotes angiogenesis via activation of the FGF2‐mediated ERK/AKT pathway	10
Chloroplast genomes of two Pueraria DC. species: sequencing, comparative analysis and molecular marker development	10
FSH enhances the inflammatory response of macrophages in the knee joint possibly through the NFκB pathway	10
Identification and functional comparison of novel alternatively spliced isoforms of human YAP	10
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Myeloperoxidase inhibition protects bone marrow mononuclear cells from DNA damage induced by the TOP2 poison anti‐cancer drug etoposide	10
An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations	10
FAM136A depletion induces mitochondrial stress and reduces mitochondrial membrane potential and ATP production	10
Entering the second decade: FEBS Open Bio in 2022	9
Cell‐specific genome‐scale metabolic modeling of SARS‐CoV‐2‐infected lung to identify antiviral enzymes	9
Time‐dependent effects of hypoxia on cell metabolism, signaling, and iron homeostasis in the hematopoietic progenitor model KG1a	9
‘Let's work together to pass medical school’: a qualitative study of medical student attitudes to teamwork, competition and collaboration	9
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Cancer cells forgo translating mRNA transcribed from genes of nonspecialized tasks	9
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Ensuring image integrity in the digital age	9
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The first crystal structure of a family 45 glycoside hydrolase from a brown‐rot fungus, Gloeophyllum trabeumGtCel45A	9
Long noncoding RNAMEG3 inhibits oral squamous cell carcinoma progression via GATA3	9
Gene expression and characterization of clonally derived murine embryonic brown and brite adipocytes	8
The anti‐cancer effect of epigallocatechin‐3‐O‐gallate against multiple myeloma cells is potentiated by 5,7‐dimethoxyflavone	8
In vitro and in vivo safety studies indicate that R15, a synthetic polyarginine peptide, could safely reverse the effects of unfractionated heparin	8
Issue Information	8
Reviewers acknowledgement	8
Benefits of exercise on cognitive impairment in alcohol use disorder following alcohol withdrawal	8
Expression and purification of E140 protein antigen fragments of Plasmodium vivax and Plasmodium berghei for serological assays	8
FEBS Open Bio: past, present and future	8
Issue Information	8
Lkb1 loss in regulatory T cells leads to dysregulation of hematopoietic stem cell expansion and differentiation in bone marrow	8
A comparative study of mouse bone marrow mesenchymal stem cells isolated using three easy‐to‐perform approaches	8
Corrigendum to “Endoplasmic reticulum stress associated with lead (Pb)‐induced olfactory epithelium toxicity in an olfactory dark basal cell line” https://doi.org/10.1002/2211‐5463.13714	8
Erratum to: BAP1 promotes viability and migration of ECA109 cells through KLF5/CyclinD1/FGF‐BP1	8
Development of a fully human anti‐GITR antibody with potent antitumor activity using H2L2 mice	8
The splicing factor DHX38/PRP16 is required for ovarian clear cell carcinoma tumorigenesis, as revealed by a CRISPR‐Cas9 screen	8
Mitochondrial complex IV defects induce metabolic and signaling perturbations that expose potential vulnerabilities in HCT116 cells	8
Microglia heterogeneity in health and disease	8
Identification of testicular cancer immune infiltrates and novel immune cell subtypes	8
Phosphorylation of RyR2 Ser‐2814 by CaMKII mediates β1‐adrenergic stress induced Ca2+‐leak from the sarcoplasmic reticulum	8
NPC1 promotes the progression of hepatocellular carcinoma by mediating the accumulation of neutrophils into the tumor microenvironment	8
Strengthening the bond with the scientific community: FEBS Open Bio in 2025	8
Activation of ERK–Drp1 signaling promotes hypoxia‐induced Aβ accumulation by upregulating mitochondrial fission and BACE1 activity	8
Cotton flower metabolites inhibit SARS‐CoV‐2 main protease	8
Retraction: Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo	8
Issue Information	7
Analysis of the regulation of undecaprenyl diphosphate dephosphorylation in Escherichia coli	7
Intermittent induction of LEA peptide by lactose enhances the expression of insecticidal proteins in Bacillus thuringiensis	7
The cytotoxic action of BCI is not dependent on its stated DUSP1 or DUSP6 targets in neuroblastoma cells	7
Ferritin heavy chain (FTH1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c‐MYC	7
Metallodrugs: an approach against invasion and metastasis in cancer treatment	7
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Revealing protein structures: crystallization of protein‐ligand complexes – co‐crystallization and crystal soaking	7
Report on the FEBS‐IUBMB‐ENABLE 1st International Molecular Biosciences PhD and Postdoc Conference	7
On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469	7
Oxidative stress in the tumor microenvironment in gastric cancer and its potential role in immunotherapy	7
Retraction statement: MicroRNA‐431 inhibits migration and invasion of hepatocellular carcinoma cells by targeting the ZEB1‐mediated epithelial–mesenchymal transition	7
Histone chaperone‐mediated co‐expression assembly of tetrasomes and nucleosomes	7
Functional parameters of spermatozoa obtained by a new selection device	7
The cryo‐EM structure of full‐length RAD52 protein contains an undecameric ring	7
Retraction statement: miR‐944 inhibits metastasis of gastric cancer by preventing the epithelial–mesenchymal transition via MACC1/Met/AKT signaling	6
RAB31 in glioma‐derived endothelial cells promotes glioma cell invasion via extracellular vesicle‐mediated enrichment of MYO1C	6
Overexpressed Smurf1 is degraded in glioblastoma cells through autophagy in a p62‐dependent manner	6

Learning objectives: an epiphany	6
High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer	6
Nanoscale‐tipped wire array injections transfer DNA directly into brain cells ex vivo and in vivo	6
Transcriptional repression shapes the identity and function of tissue macrophages	6
Issue Information	6
Tyr76 is essential for the cold adaptation of a class II glutaredoxin 4 with a heat‐labile structure from the Arctic bacteriumSphingomonassp.	6
Characterization of the complete chloroplast genome of Rhodiola sachalinensis and comparative analysis with its congeneric plants	6
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Intracellular protein crystallization in living insect cells	6
Toll‐like receptor 9 signaling in chronic lymphocytic leukemia cell lines	6
Expression of a Crry/p65 is reduced in acute lung injury induced by extracellular histones	6
Real‐world genomic landscape of colon and rectal cancer	6
RETRACTION: MicroRNA‐498 Reduces the Proliferation and Invasion of Colorectal Cancer Cells via Targeting Bcl‐2	6
Knockdown of TMEM160 leads to an increase in reactive oxygen species generation and the induction of the mitochondrial unfolded protein response	6
Acquired and intrinsic resistance to vemurafenib in BRAFV600E‐driven melanoma brain metastases	6
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Liraglutide enhances the effect of checkpoint blockade in lung and liver cancers through the inhibition of neutrophil extracellular traps	6
Mutations in RPS19 may affect ribosome function and biogenesis in Diamond Blackfan anemia	6
Talks	6
A non‐fluorescent immunohistochemistry method for measuring autophagy flux using MAP1LC3/LC3 and SQSTM1 as core markers	6
The interplay between pathogens and Atg8 family proteins: thousand‐faced interactions	6
Characterisation of a common hotspot variant in acute intermittent porphyria sheds light on the mechanism of hydroxymethylbilane synthase function	6
A brief overview of BNIP3L/NIX receptor‐mediated mitophagy	6
Identification and analysis of short indels inducing exon extension/shrinkage events	6
Cordycepin inhibits cell senescence by ameliorating lysosomal dysfunction and inducing autophagy through the AMPK and mTOR–p70S6K pathway	6
Front Cover	6
Issue Information	6
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CDK5 interacts with MST2 and modulates the Hippo signalling pathway	6
Correction to “Characterization of the cHS4 insulator in mouse embryonic stem cells”	6
Biochemical characterization of the human ubiquitous glucose‐6‐phosphatase in neutrophil granulocytes	5
Biochemical characterization and gene structure analysis of the 24‐kDa glutathione transferase sigma from Taenia solium	5
Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study	5
On the design of a constitutively active peptide asparaginyl ligase for facile protein conjugation	5
Tryptophan‐sensing receptor GPR142 expression levels are directly regulated by proinflammatory cytokines in ghrelin‐producing cells	5
Structure prediction analysis of human core TIM23 complex reveals conservation of the protein translocation mechanism	5
Intrabacterial lipid inclusion‐associated proteins: a core machinery conserved from saprophyte Actinobacteria to the human pathogen Mycobacterium tuberculosis	5
Malus pumila Mill. cv Annurca apple extract might be therapeutically useful against oxidative stress and patterned hair loss	5
Biochemical and in silico identification of the active site and the catalytic mechanism of the circadian deadenylase HESPERIN	5
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WDHD1 is over‐expressed in nasopharyngeal carcinoma and may control the expression of ITGAV	5
Diacylglycerol kinase ζ interacts with sphingomyelin synthase 1 and sphingomyelin synthase‐related protein via different regions	5
Biological and clinical implications of metastasis‐associated circular RNAs in oesophageal squamous cell carcinoma	5
The dynamics of cell death patterns and regeneration during acute liver injury in mice	5
MYPT1 inhibits the metastasis of renal clear cell carcinoma via the MAPK8/N‐cadherin pathway	5
Hesperidin enhances intestinal barrier function in Caco‐2 cell monolayers via AMPK‐mediated tight junction‐related proteins	5
SMARCA4 mutations and expression in lung adenocarcinoma: prognostic significance and impact on the immunotherapy response	5
hnRNP A1 and hnRNP C associate with miR‐17 and miR‐18 in thyroid cancer cells	5
Feeder cells treated with ethanol can be used to maintain self‐renewal and pluripotency of human pluripotent stem cells	5
Development of a mouse embryonic stem cell model for investigating the functions of the linker histone H1‐4	5
Using a ‘Students as Partners’ model to develop an authentic assessment promoting employability skills in undergraduate life science education	5
Establishment of a risk score model for bladder urothelial carcinoma based on energy metabolism‐related genes and their relationships with immune infiltration	5
Development and validation of a four‐lipid metabolism gene signature for diagnosis of pancreatic cancer	5
Alkane biosynthesis gene expression and its increased production in recombinant cyanobacteria	5
Flow cytometric resolution of yeast is affected by enzymatic treatment and culture media	5
On the difficulties of characterizing weak protein interactions that are critical for neurotransmitter release	5
Beta cell regeneration upon magainin and growth hormone treatment as a possible alternative to insulin therapy	5
HPV18 E6 inhibits α‐ketoglutarate‐induced pyroptosis of esophageal squamous cell carcinoma cells via the P53/MDH1/ROS/GSDMC pathway	5
Isolation and characterization of peritoneal microvascular pericytes	5
Diagnostic and therapeutic targeting of pathological tau proteins in neurodegenerative disorders	5
Issue Information	5
Cylindracin, a Cys‐rich protein expressed in the fruiting body of Cyclocybe cylindracea, inhibits growth of filamentous fungi but not yeasts or bacteria	4
Overexpression of HPRT1 is associated with poor prognosis in head and neck squamous cell carcinoma	4
Neutrophil and macrophage crosstalk might be a potential target for liver regeneration	4
Oleanolic acid alleviates obesity‐induced skeletal muscle atrophy via the PI3K/Akt signaling pathway	4
Lipid dysmetabolism in ceruloplasmin‐deficient mice revealed both in vivo and ex vivo by MRI, MRS and NMR analyses	4
Structures of distantly related interacting protein homologs are less divergent than non‐interacting homologs	4
Corrigendum to: Determination of the optimal concentration and duration of C5aR antagonist application in an inflammatory model of human dental pulp cells	4
Cardiovascular risk of dietary trimethylamine oxide precursors and the therapeutic potential of resveratrol and its derivatives	4
Issue Information	4
Withdrawal statement: [Liu, X., Qiao, L., Zhang, H., Zhang, C., Ding, R., Kang, J., Liu, Y., Lin, J. and Yan, X. (2023), Argonaute 2 regulates LPS‐induced inflammation in microglial BV2 cells by targe	4
Alcohol induces α2‐6sialo mucin O‐glycans that kill U937 macrophages mediated by sialic acid‐binding immunoglobulin‐like lectin 7 (Siglec 7)	4
Corrigendum to: Identification and expression analysis of LEA gene family members in pepper (Capsicum annuum L.) https://doi.org/10.1002/2211‐5463.13718	4
Peptide mimetic NC114 induces growth arrest by preventing PKCδ activation and FOXM1 nuclear translocation in colorectal cancer cells	4
Functional analysis of the N‐terminal region of acetylxylan esterase from Caldanaerobacter subterraneus subsp. tengcongensis	4
Rapid isolation and cryo‐EM characterization of synaptic vesicles from mammalian brain	4
The protein tyrosine phosphatase PPH‐7 is required for fertility and embryonic development in C. elegans at elevated temperatures	4
ARL2 is required for homologous recombination repair and colon cancer stem cell survival	4
Microbiological investigation of pregnancies following vaginal radical trachelectomy using 16S rRNA sequencing of FFPE placental specimens	4
Obesity‐induced oxidative stress and mitochondrial dysfunction negatively affect sperm quality	4
Retraction statement: microRNA‐497 inhibits cell proliferation and induces apoptosis by targeting YAP1 in human hepatocellular carcinoma	4
Abstracts	4
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LRRK2 negatively regulates glucose tolerance via regulation of membrane translocation of GLUT4 in adipocytes	4
Exploring gene regulatory interaction networks and predicting therapeutic molecules for hypopharyngeal cancer and EGFR‐mutated lung adenocarcinoma	4
Fluoxetine partially alleviates inflammation in the kidney of socially stressed male C57 BL/6 mice	4
Titanium particles inhibit bone marrow mesenchymal stem cell osteogenic differentiation through the MAPK signaling pathway	4
Identification of ferroptosis‐related genes as potential biomarkers of tongue squamous cell carcinoma using an integrated bioinformatics approach	4
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How hydrolytic exoribonucleases impact human disease: Two sides of the same story	4
Hippocampal tau‐induced GRIN3A deficiency in Alzheimer's disease	4
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