Acta Pharmaceutica Sinica B

Article	Citations
Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods	1520
Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites	494
Why 90% of clinical drug development fails and how to improve it?	359
Gasdermin D in pyroptosis	274
Long non-coding RNAs: From disease code to drug role	245
The biology, function, and applications of exosomes in cancer	214
Metal-organic frameworks for advanced drug delivery	206
Crystal structure of SARS-CoV-2 papain-like protease	201
Mitochondrial quality control mechanisms as molecular targets in cardiac ischemia–reperfusion injury	189
Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies	186
Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma	178
The role of tumor-associated macrophages (TAMs) in tumor progression and relevant advance in targeted therapy	177
Potential therapeutic effects of dipyridamole in the severely ill patients with COVID-19	166
Recent progress of hypoxia-modulated multifunctional nanomedicines to enhance photodynamic therapy: opportunities, challenges, and future development	161
Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways	154
Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway	148
Targeting autophagy-related protein kinases for potential therapeutic purpose	139
Evolution of blood–brain barrier in brain diseases and related systemic nanoscale brain-targeting drug delivery strategies	136
Bioactive natural compounds against human coronaviruses: a review and perspective	131
New opportunities and challenges of natural products research: When target identification meets single-cell multiomics	129
Traditional Chinese medicine in COVID-19	128
Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis	127
Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management	126
Recent advances in drug delivery systems for targeting cancer stem cells	123
Ginsenosides in Panax genus and their biosynthesis	120

Oral delivery of proteins and peptides: Challenges, status quo and future perspectives	120
Small interfering RNA for cancer treatment: overcoming hurdles in delivery	119
Antibody–drug conjugates: Recent advances in linker chemistry	119
The progress and perspective of nanoparticle-enabled tumor metastasis treatment	116
Doxorubicin-loaded bacterial outer-membrane vesicles exert enhanced anti-tumor efficacy in non-small-cell lung cancer	115
Combating COVID-19 with integrated traditional Chinese and Western medicine in China	115
Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles and nanoemulsions: A current overview of in vivo studies	115
Pharmaceutical cocrystals: A review of preparations, physicochemical properties and applications	113
Alterations of DNA damage response pathway: Biomarker and therapeutic strategy for cancer immunotherapy	113
Identifying potential anti-COVID-19 pharmacological components of traditional Chinese medicine Lianhuaqingwen capsule based on human exposure and ACE2 biochromatography screening	108
Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis	108
Pulmonary delivery of siRNA against acute lung injury/acute respiratory distress syndrome	106
Current approaches of nanomedicines in the market and various stage of clinical translation	106
Synergetic delivery of triptolide and Ce6 with light-activatable liposomes for efficient hepatocellular carcinoma therapy	104
Advances and challenges in the treatment of esophageal cancer	102
Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses	100
Recent advances of antibody drug conjugates for clinical applications	100
Natural exosome-like nanovesicles from edible tea flowers suppress metastatic breast cancer via ROS generation and microbiota modulation	100
Epigenetic strategies synergize with PD-L1/PD-1 targeted cancer immunotherapies to enhance antitumor responses	99
Influencing factors and strategies of enhancing nanoparticles into tumors in vivo	97
In vivo delivery of CRISPR-Cas9 therapeutics: Progress and challenges	97
Analysis on herbal medicines utilized for treatment of COVID-19	96
Biological drug and drug delivery-mediated immunotherapy	96
Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1	95
The influence of the gut microbiota on the bioavailability of oral drugs	94
Gene therapy for neurodegenerative disorders: advances, insights and prospects	93
Self-assembled natural phytochemicals for synergistically antibacterial application from the enlightenment of traditional Chinese medicine combination	93
The cGAS–STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy	92
Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5	91
Recent advances in drug delivery applications of cubosomes, hexosomes, and solid lipid nanoparticles	90
Angiotensin-converting enzyme 2 (ACE2): SARS-CoV-2 receptor and RAS modulator	89
Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1	88
Exploration and insights into the cellular internalization and intracellular fate of amphiphilic polymeric nanocarriers	87
Monoacylglycerol lipase inhibitors: modulators for lipid metabolism in cancer malignancy, neurological and metabolic disorders	86
Recent development on COX-2 inhibitors as promising anti-inflammatory agents: The past 10 years	85
Recent developments on PET radiotracers for TSPO and their applications in neuroimaging	83
Bone marrow mesenchymal stem cells-derived exosomes for penetrating and targeted chemotherapy of pancreatic cancer	79
Nanomedicine-based drug delivery towards tumor biological and immunological microenvironment	79
Integrins as attractive targets for cancer therapeutics	78
Development of non-nucleoside reverse transcriptase inhibitors (NNRTIs): our past twenty years	78
Cell membrane-derived vesicles for delivery of therapeutic agents	78
Targeted nanomedicines remodeling immunosuppressive tumor microenvironment for enhanced cancer immunotherapy	78
Nanomedicine for acute respiratory distress syndrome: The latest application, targeting strategy, and rational design	76
An update on oral drug delivery via intestinal lymphatic transport	76
Emerging role of natural products in cancer immunotherapy	75
GSH-sensitive polymeric prodrug: Synthesis and loading with photosensitizers as nanoscale chemo-photodynamic anti-cancer nanomedicine	74
Ginsenoside Rg1 ameliorates blood–brain barrier disruption and traumatic brain injury via attenuating macrophages derived exosomes miR-21 release	73
Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation	73
Recent progress in sono-photodynamic cancer therapy: From developed new sensitizers to nanotechnology-based efficacy-enhancing strategies	73
Recent developments in the medicinal chemistry of single boron atom-containing compounds	72

Carbohydrate-based drugs launched during 2000−2021	71
Recent advances in nanomedicines for the treatment of ischemic stroke	68
Symphony of nanomaterials and immunotherapy based on the cancer–immunity cycle	68
The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatment	68
Pure drug nano-assemblies: A facile carrier-free nanoplatform for efficient cancer therapy	67
Selective inhibition of CDK4/6: A safe and effective strategy for developing anticancer drugs	67
Cathepsin B-responsive and gadolinium-labeled branched glycopolymer-PTX conjugate-derived nanotheranostics for cancer treatment	66
Development of small-molecule tropomyosin receptor kinase (TRK) inhibitors for NTRK fusion cancers	66
Nanomedicines modulating tumor immunosuppressive cells to enhance cancer immunotherapy	66
Bioresponsive immune-booster-based prodrug nanogel for cancer immunotherapy	65
Natural products as LSD1 inhibitors for cancer therapy	65
Cell membrane coated-nanoparticles for cancer immunotherapy	65
A cyclodextrin-based nanoformulation achieves co-delivery of ginsenoside Rg3 and quercetin for chemo-immunotherapy in colorectal cancer	64
Pharmaceutical strategies to extend pulmonary exposure of inhaled medicines	63
Delivery strategies for macromolecular drugs in cancer therapy	63
Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies	62
GSH-responsive SN38 dimer-loaded shape-transformable nanoparticles with iRGD for enhancing chemo-photodynamic therapy	62
A comprehensive review of integrative pharmacology-based investigation: A paradigm shift in traditional Chinese medicine	61
Platinum complexes of curcumin delivered by dual-responsive polymeric nanoparticles improve chemotherapeutic efficacy based on the enhanced anti-metastasis activity and reduce side effects	60
D3Targets-2019-nCoV: a webserver for predicting drug targets and for multi-target and multi-site based virtual screening against COVID-19	60
The role of lysosome in regulated necrosis	60
Insight into chemical basis of traditional Chinese medicine based on the state-of-the-art techniques of liquid chromatography−mass spectrometry	59
Targeted delivery of hyaluronic acid nanomicelles to hepatic stellate cells in hepatic fibrosis rats	59
Impairment of the autophagy–lysosomal pathway in Alzheimer's diseases: Pathogenic mechanisms and therapeutic potential	58
Self-assembled small molecule natural product gel for drug delivery: a breakthrough in new application of small molecule natural products	57
A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis	57
Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators	57
Nanomedicines for the treatment of rheumatoid arthritis: State of art and potential therapeutic strategies	57
Receptor-mediated targeted drug delivery systems for treatment of inflammatory bowel disease: Opportunities and emerging strategies	57
Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology: Implications for Alzheimer's disease therapy	56
Membrane-disruptive peptides/peptidomimetics-based therapeutics: Promising systems to combat bacteria and cancer in the drug-resistant era	56
Delivery strategies of amphotericin B for invasive fungal infections	56
Rational drug design, synthesis, and biological evaluation of novel chiral tetrahydronaphthalene-fused spirooxindole as MDM2-CDK4 dual inhibitor against glioblastoma	56
SUV39H1 deficiency suppresses clear cell renal cell carcinoma growth by inducing ferroptosis	55
Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway	55
SIRT6 as a key event linking P53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation	55
Targeting necroptosis in anticancer therapy: mechanisms and modulators	55
Opportunities and challenges of three-dimensional printing technology in pharmaceutical formulation development	55
A review of existing strategies for designing long-acting parenteral formulations: Focus on underlying mechanisms, and future perspectives	55
Remote loading paclitaxel–doxorubicin prodrug into liposomes for cancer combination therapy	55
Small-molecule MDM2/X inhibitors and PROTAC degraders for cancer therapy: advances and perspectives	54
Spatial-resolved metabolomics reveals tissue-specific metabolic reprogramming in diabetic nephropathy by using mass spectrometry imaging	53
Nucleic acid nanoassembly-enhanced RNA therapeutics and diagnosis	53
Targeting autophagy using small-molecule compounds to improve potential therapy of Parkinson's disease	53
Emerging vaccine nanotechnology: From defense against infection to sniping cancer	53
Tailored core‒shell dual metal–organic frameworks as a versatile nanomotor for effective synergistic antitumor therapy	53
Tumor microenvironments self-activated nanoscale metal-organic frameworks for ferroptosis based cancer chemodynamic/photothermal/chemo therapy	53
TIMP1 preserves the blood–brain barrier through interacting with CD63/integrin 1 complex and regulating downstream FAK/RhoA signaling	52
mRNA cancer vaccines: Advances, trends and challenges	52
Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing	52
Target-based anticancer indole derivatives and insight into structure‒activity relationship: A mechanistic review update (2018–2021)	52
The chromosome-level reference genome assembly for Dendrobium officinale and its utility of functional genomics research and molecular breeding study	52
Synthesis, in vitro and in vivo biological evaluation of novel lappaconitine derivatives as potential anti-inflammatory agents	51
Recent advances in microneedles-mediated transdermal delivery of protein and peptide drugs	50
The phytochemical, biological, and medicinal attributes of phytoecdysteroids: An updated review	50
Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls	49
Natural products, PGC-1 , and Duchenne muscular dystrophy	49
Artemisinin and artemisinin derivatives as anti-fibrotic therapeutics	49
Design, synthesis, and biological evaluation of quinazolin-4(3H)-one derivatives co-targeting poly(ADP-ribose) polymerase-1 and bromodomain containing protein 4 for breast cancer therapy	49
Validation and invalidation of SARS-CoV-2 main protease inhibitors using the Flip-GFP and Protease-Glo luciferase assays	49
A novel cyclic peptide targeting LAG-3 for cancer immunotherapy by activating antigen-specific CD8+ T cell responses	49
Self-propelled nanomotor reconstructs tumor microenvironment through synergistic hypoxia alleviation and glycolysis inhibition for promoted anti-metastasis	49
Impact of particle size and pH on protein corona formation of solid lipid nanoparticles: A proof-of-concept study	48
Discovery of the first potent proteolysis targeting chimera (PROTAC) degrader of indoleamine 2,3-dioxygenase 1	48
Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment	48
Discovery of an orally active VHL-recruiting PROTAC that achieves robust HMGCR degradation and potent hypolipidemic activity in vivo	48
Notoginsenoside Ft1 acts as a TGR5 agonist but FXR antagonist to alleviate high fat diet-induced obesity and insulin resistance in mice	47
A nanocleaner specifically penetrates the blood‒brain barrier at lesions to clean toxic proteins and regulate inflammation in Alzheimer's disease	47
Bile acid coordinates microbiota homeostasis and systemic immunometabolism in cardiometabolic diseases	47
Lactoferrin-mediated macrophage targeting delivery and patchouli alcohol-based therapeutic strategy for inflammatory bowel diseases	47
Smart drug delivery systems for precise cancer therapy	47
Recent advances in developing small-molecule inhibitors against SARS-CoV-2	46
Layered dissolving microneedles as a need-based delivery system to simultaneously alleviate skin and joint lesions in psoriatic arthritis	46
In situ metabolomics in nephrotoxicity of aristolochic acids based on air flow-assisted desorption electrospray ionization mass spectrometry imaging	46
Anticancer drug discovery by targeting cullin neddylation	46
Diversity of the reaction mechanisms of SAM-dependent enzymes	45
MiR-142-3p enhances chemosensitivity of breast cancer cells and inhibits autophagy by targeting HMGB1	45
A smart MnO2-doped graphene oxide nanosheet for enhanced chemo-photodynamic combinatorial therapy via simultaneous oxygenation and glutathione depletion	44
Nature-derived compounds modulating Wnt/ -catenin pathway: a preventive and therapeutic opportunity in neoplastic diseases	44
CAR-T cells: Early successes in blood cancer and challenges in solid tumors	44

Natural compounds modulate the autophagy with potential implication of stroke	44
Therapeutic regulation of autophagy in hepatic metabolism	44
Identification of ferroptosis as a novel mechanism for antitumor activity of natural product derivative a2 in gastric cancer	43
Effect of physicochemical properties on in vivo fate of nanoparticle-based cancer immunotherapies	43
Discovery of thiosemicarbazone derivatives as effective New Delhi metallo-β-lactamase-1 (NDM-1) inhibitors against NDM-1 producing clinical isolates	43
Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy	43
Self-assembled FeS-based cascade bioreactor with enhanced tumor penetration and synergistic treatments to trigger robust cancer immunotherapy	42
Dual-responsive nanoparticles with transformable shape and reversible charge for amplified chemo-photodynamic therapy of breast cancer	42
Manipulation of immune‒vascular crosstalk: new strategies towards cancer treatment	42
Cancer stem cell-targeted chimeric antigen receptor (CAR)-T cell therapy: Challenges and prospects	42
Non-apoptotic cell death-based cancer therapy: Molecular mechanism, pharmacological modulators, and nanomedicine	42
Comparative study of mucoadhesive and mucus-penetrative nanoparticles based on phospholipid complex to overcome the mucus barrier for inhaled delivery of baicalein	41
Functional metabolomics reveal the role of AHR/GPR35 mediated kynurenic acid gradient sensing in chemotherapy-induced intestinal damage	41
Peptide–drug conjugates (PDCs): a novel trend of research and development on targeted therapy, hype or hope?	41
Recent advances in screening active components from natural products based on bioaffinity techniques	40
Magnetic systems for cancer immunotherapy	40
Dose selection of chloroquine phosphate for treatment of COVID-19 based on a physiologically based pharmacokinetic model	40
Mitochondrial complex I as a therapeutic target for Alzheimer's disease	40
Intracellular codelivery of anti-inflammatory drug and anti-miR 155 to treat inflammatory disease	39
Evodiamine-inspired dual inhibitors of histone deacetylase 1 (HDAC1) and topoisomerase 2 (TOP2) with potent antitumor activity	39
The regulatory and modulatory roles of TRP family channels in malignant tumors and relevant therapeutic strategies	39
Inhibitory effects of baicalein against herpes simplex virus type 1	39
Exploring the hydrophobic channel of NNIBP leads to the discovery of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives as potent HIV-1 NNRTIs	39
Mitochondria targeting drugs for neurodegenerative diseases—Design, mechanism and application	39
The disruption of protein−protein interactions with co-chaperones and client substrates as a strategy towards Hsp90 inhibition	39
Abrogation of HnRNP L enhances anti-PD-1 therapy efficacy via diminishing PD-L1 and promoting CD8+ T cell-mediated ferroptosis in castration-resistant prostate cancer	39
Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase	39
Novel compound FLZ alleviates rotenone-induced PD mouse model by suppressing TLR4/MyD88/NF-κB pathway through microbiota–gut–brain axis	38
Can remdesivir and its parent nucleoside GS-441524 be potential oral drugs? An in vitro and in vivo DMPK assessment	38
Enhanced uptake and anti-maturation effect of celastrol-loaded mannosylated liposomes on dendritic cells for psoriasis treatment	38
Icariside Ⅱ, a main compound in Epimedii Folium, induces idiosyncratic hepatotoxicity by enhancing NLRP3 inflammasome activation	38
Homo-PROTAC mediated suicide of MDM2 to treat non-small cell lung cancer	38
Scutellarin inhibits caspase-11 activation and pyroptosis in macrophages via regulating PKA signaling	38
Escape from abluminal LRP1-mediated clearance for boosted nanoparticle brain delivery and brain metastasis treatment	38
Role of CD8+ T lymphocyte cells: Interplay with stromal cells in tumor microenvironment	38
New guaiane-type sesquiterpenoid dimers from Artemisia atrovirens and their antihepatoma activity	37
Deficiency of anti-inflammatory cytokine IL-4 leads to neural hyperexcitability and aggravates cerebral ischemia–reperfusion injury	37
Gold nanoparticle-directed autophagy intervention for antitumor immunotherapy via inhibiting tumor-associated macrophage M2 polarization	37
Photothermal/matrix metalloproteinase-2 dual-responsive gelatin nanoparticles for breast cancer treatment	37
Transdermal delivery of Chinese herbal medicine extract using dissolvable microneedles for hypertrophic scar treatment	37
Milk-derived exosomes exhibit versatile effects for improved oral drug delivery	37
Mechanisms of immune checkpoint inhibitor-mediated liver injury	37
In vitro and in vivo correlation for lipid-based formulations: Current status and future perspectives	36
Tumor-derived exosomes: Nanovesicles made by cancer cells to promote cancer metastasis	36
A BRD4 PROTAC nanodrug for glioma therapy via the intervention of tumor cells proliferation, apoptosis and M2 macrophages polarization	36
Recent advances in bacteriophage-based therapeutics: Insight into the post-antibiotic era	36
Discovery of [1,2,3]triazolo[4,5-d]pyrimidine derivatives as highly potent, selective, and cellularly active USP28 inhibitors	36
Activated PKB/GSK-3β synergizes with PKC-δ signaling in attenuating myocardial ischemia/reperfusion injury via potentiation of NRF2 activity: Therapeutic efficacy of dihydrotanshinone-I	36
A homogenous nanoporous pulmonary drug delivery system based on metal-organic frameworks with fine aerosolization performance and good compatibility	35
Tubeimoside-1 induces TFEB-dependent lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting mTOR	35
The Ca2+-activated chloride channel ANO1/TMEM16A: An emerging therapeutic target for epithelium-originated diseases?	35
Intelligent lesion blood–brain barrier targeting nano-missiles for Alzheimer's disease treatment by anti-neuroinflammation and neuroprotection	35
Injectable thermo-responsive nano-hydrogel loading triptolide for the anti-breast cancer enhancement via localized treatment based on “two strikes” effects	35
Targeted inhibition of GRK2 kinase domain by CP-25 to reverse fibroblast-like synoviocytes dysfunction and improve collagen-induced arthritis in rats	35
Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy	35
Nano-bio interfaces effect of two-dimensional nanomaterials and their applications in cancer immunotherapy	35
Nature's marvels endowed in gaseous molecules I: Carbon monoxide and its physiological and therapeutic roles	35
Enterovirus A71 antivirals: Past, present, and future	35
Co-delivery of photosensitizer and diclofenac through sequentially responsive bilirubin nanocarriers for combating hypoxic tumors	34
Application of immune checkpoint targets in the anti-tumor novel drugs and traditional Chinese medicine development	34
Microneedle-based devices for point-of-care infectious disease diagnostics	34
Organic carbon monoxide prodrug, BW-CO-111, in protection against chemically-induced gastric mucosal damage	34
Extracellular vesicles: Emerging tools as therapeutic agent carriers	34
Gli1 promotes epithelial–mesenchymal transition and metastasis of non-small cell lung carcinoma by regulating snail transcriptional activity and stability	34
Conditional reprogramming: next generation cell culture	34
Approved HIV reverse transcriptase inhibitors in the past decade	34
Bispecific prodrug nanoparticles circumventing multiple immune resistance mechanisms for promoting cancer immunotherapy	33
Hypoxia-degradable and long-circulating zwitterionic phosphorylcholine-based nanogel for enhanced tumor drug delivery	33
Mechanistic insights of the controlled release capacity of polar functional group in transdermal drug delivery system: the relationship of hydrogen bonding strength and controlled release capacity	33
Applying artificial intelligence for cancer immunotherapy	33
A novel inhibitor of N6-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities	33
Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota	33
Inhibiting collagen I production and tumor cell colonization in the lung via miR-29a-3p loading of exosome-/liposome-based nanovesicles	33
Prediction of lipid nanoparticles for mRNA vaccines by the machine learning algorithm	32
Inhibition of the CDK9–cyclin T1 protein–protein interaction as a new approach against triple-negative breast cancer	32
Celastrol targets adenylyl cyclase-associated protein 1 to reduce macrophages-mediated inflammation and ameliorates high fat diet-induced metabolic syndrome in mice	32
Genome mining combined metabolic shunting and OSMAC strategy of an endophytic fungus leads to the production of diverse natural products	32
Precise delivery of obeticholic acid via nanoapproach for triggering natural killer T cell-mediated liver cancer immunotherapy	31
Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease	31
NAMPT-targeting PROTAC promotes antitumor immunity via suppressing myeloid-derived suppressor cell expansion	31
Can nanoparticles and nano‒protein interactions bring a bright future for insulin delivery?	31
Inhaled curcumin mesoporous polydopamine nanoparticles against radiation pneumonitis	31
Bile acid homeostasis in female mice deficient in Cyp7a1 and Cyp27a1	31
Benzimidazole and its derivatives as cancer therapeutics: The potential role from traditional to precision medicine	31
Integrative lipidomic and transcriptomic study unravels the therapeutic effects of saikosaponins A and D on non-alcoholic fatty liver disease	31
Natural products remodel cancer-associated fibroblasts in desmoplastic tumors	31
Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migration of pancreatic cancer cells	31
ZDHHC12-mediated claudin-3 S-palmitoylation determines ovarian cancer progression	31
Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors	31
Apolipoprotein E and Alzheimer's disease	31
First small-molecule PROTACs for G protein-coupled receptors: inducing 1A-adrenergic receptor degradation	31
A smart dual-drug nanosystem based on co-assembly of plant and food-derived natural products for synergistic HCC immunotherapy	30
Energy metabolism disorders and potential therapeutic drugs in heart failure	30
Engineering a folic acid-decorated ultrasmall gemcitabine nanocarrier for breast cancer therapy: Dual targeting of tumor cells and tumor-associated macrophages	30
Phospholipid membrane-decorated deep-penetrated nanocatalase relieve tumor hypoxia to enhance chemo-photodynamic therapy	30