Acta Pharmaceutica Sinica B

Article	Citations
Table of Contents	662
Cover Story	343
A novel PI3K inhibitor XH30 suppresses orthotopic glioblastoma and brain metastasis in mice models	299
EHMT2 promotes tumorigenesis in GNAQ/11-mutant uveal melanoma via ARHGAP29-mediated RhoA pathway	295
Novel carbazole attenuates vascular remodeling through STAT3/CIAPIN1 signaling in vascular smooth muscle cells	284
Iron and siRNA co-encapsulated ferritin nanocages induce ferroptosis synergistically for cancer therapy	265
Regulation of histidine metabolism by Lactobacillus Reuteri mediates the pathogenesis and treatment of ischemic stroke	260
Extracellular vesicles deliver thioredoxin to rescue stem cells from senescence and intervertebral disc degeneration via a feed-forward circuit of the NRF2/AP-1 composite pathway	245
Remodeling tumor immunosuppressive microenvironment through dual activation of immunogenic panoptosis and ferroptosis by H2S-amplified nanoformulation to enhance cancer immunotherapy	196
Cover Story	194
Glutamate-releasing BEST1 channel is a new target for neuroprotection against ischemic stroke with wide time window	174
Emerging non-antibody‒drug conjugates (non-ADCs) therapeutics of toxins for cancer treatment	171
Coating with flexible DNA network enhanced T-cell activation and tumor killing for adoptive cell therapy	171
A novel biological sources consistency evaluation method reveals high level of biodiversity within wild natural medicine: A case study of Amynthas earthworms as “Guang Dilong”	169
Cover Story	166
Fenofibrate-promoted hepatomegaly and liver regeneration are PPARα-dependent and partially related to the YAP pathway	165
Sequential dual-locking strategy using photoactivated Pt(IV)-based metallo-nano prodrug for enhanced chemotherapy and photodynamic efficacy by triggering ferroptosis and macrophage polarization	157
The clinical antiprotozoal drug nitazoxanide and its metabolite tizoxanide extend Caenorhabditis elegans lifespan and healthspan	155
Table of Contents	155
Spirohypertones A and B as potent antipsoriatics: Tumor necrosis factor-α inhibitors with unprecedented chemical architectures	154
Harnessing the cyclization strategy for new drug discovery	153
Self-assembled multifunctional nanotheranostics against circulating tumor clusters in metastatic breast cancer	152
A four-protein metabolon assembled by a small peptide protein creates the pentacyclic carbonate ring of aldgamycins	150
Preclinical studies of the triazolo[1,5-a]pyrimidine derivative WS-716 as a highly potent, specific and orally active P-glycoprotein (P-gp) inhibitor	150
Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia	150

Ultra-short-course and intermittent TB47-containing oral regimens produce stable cure against Buruli ulcer in a murine model and prevent the emergence of resistance for Mycobacterium ulcerans	146
Peroxidase from foxtail millet bran exerts anti-colorectal cancer activity via targeting cell-surface GRP78 to inactivate STAT3 pathway	143
Synthesis and evaluation of TSPO-targeting radioligand [18F]F-TFQC for PET neuroimaging in epileptic rats	135
Facile synthesis of insulin fusion derivatives through sortase A ligation	133
Guest Editors of Special Column on Drug Targets and Drug Development for Alzheimer’s Disease	131
ACAT1 deficiency in myeloid cells promotes glioblastoma progression by enhancing the accumulation of myeloid-derived suppressor cells	128
Drug discovery in China: A snapshot of recent progress	127
Reconstitution of biosynthetic pathway for mushroom-derived cyathane diterpenes in yeast and generation of new “non-natural” analogues	120
Activating Connexin43 gap junctions primes adipose tissue for therapeutic intervention	120
Editor Profiles: Guest Editors of Special Column on A New Era of Nanobiomaterial-based Drug Delivery	119
In vivo testing of mucus-permeating nanoparticles for oral insulin delivery using Caenorhabditis elegans as a model under hyperglycemic conditions	119
Directly targeting BAX for drug discovery: Therapeutic opportunities and challenges	116
HR121 targeting HR2 domain in S2 subunit of spike protein can serve as a broad-spectrum SARS-CoV-2 inhibitor via intranasal administration	115
Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases	112
Critical involvement of lysyl oxidase in seizure-induced neuronal damage through ERK-Alox5-dependent ferroptosis and its therapeutic implications	109
Construction and characterization of a humanized SLCO1B1 rat model with its application in evaluating the uptake of different statins	108
Table of Contents	107
Editor Profiles: Guest Editors of Special Column on Antiviral Drug Discovery and Pharmacology	107
Commentary: Indirect action pattern: A remote and cross-organ pharmacological mechanism for drug innovation	101
Editorial of Special Column “Novel Peptides and Peptidomimetics in Drug Discovery”	99
From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution	99
Development of a highly-specific 18F-labeled irreversible positron emission tomography tracer for monoacylglycerol lipase mapping	98
Commentary: A nearly forgotten class of anti-inflammatory lipid molecules in central nervous system	98
Cover Story	97
Transformation of peptides to small molecules in medicinal chemistry: Challenges and opportunities	95
Spatial metabolomics highlights metabolic reprogramming in acute myeloid leukemia mice through creatine pathway	94
Reprogramming tumor-associated macrophages and inhibiting tumor neovascularization by targeting MANF–HSF1–HSP70-1 pathway: An effective treatment for hepatocellular carcinoma	93
Metabolic basis of solute carrier transporters in treatment of type 2 diabetes mellitus	92
Targeted isolation of antiviral cinnamoylphloroglucinol-terpene adducts from Cleistocalyx operculatus by building blocks-based molecular networking approach	91
Single-cell transcriptomics reveals the ameliorative effect of rosmarinic acid on diabetic nephropathy-induced kidney injury by modulating oxidative stress and inflammation	88
The emerging tumor microbe microenvironment: From delineation to multidisciplinary approach-based interventions	87
Research and development of Chinese anti-COVID-19 drugs	86
Endoplasmic reticulum-targeted delivery of celastrol and PD-L1 siRNA for reinforcing immunogenic cell death and potentiating cancer immunotherapy	85
Multidimensional autophagy nano-regulator boosts Alzheimer's disease treatment by improving both extra/intraneuronal homeostasis	84
Structural repurposing of SGLT2 inhibitor empagliflozin for strengthening anti-heart failure activity with lower glycosuria	84
A reporter gene assay for determining the biological activity of therapeutic antibodies targeting TIGIT	82
A potentially serious adverse effect of GLP-1 receptor agonists	82
Activation of PXR causes drug interactions with Paxlovid in transgenic mice	82
SMIP-30, a potent and selective PPM1A inhibitor with potential to treat tuberculosis	81
Environmental toxicant-induced maladaptive mitochondrial changes: A potential unifying mechanism in fatty liver disease?	80
The regulatory mechanisms and inhibitors of isocitrate dehydrogenase 1 in cancer	77
A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors	77
Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma	77
On-demand integrated nano-engager converting cold tumors to hot via increased DNA damage and dual immune checkpoint inhibition	76
Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy	75
Discovery and development of brain-penetrant 18F-labeled radioligands for neuroimaging of the sigma-2 receptors	74
Pharmaceutical applications of framework nucleic acids	74
PXR activation impairs hepatic glucose metabolism partly via inhibiting the HNF4α–GLUT2 pathway	74
Overcoming Mycobacterium tuberculosis through small molecule inhibitors to break down cell wall synthesis	73
TBC1D15 deficiency protects against doxorubicin cardiotoxicity via inhibiting DNA-PKcs cytosolic retention and DNA damage	71

[18F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models	69
SARS-CoV-2 spike host cell surface exposure promoted by a COPI sorting inhibitor	69
Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles	68
Functional identification of the terpene synthase family involved in diterpenoid alkaloids biosynthesis in Aconitum carmichaelii	68
WSB1 regulates c-Myc expression through β-catenin signaling and forms a feedforward circuit	68
Dual alarmin-receptor-specific targeting peptide systems for treatment of sepsis	67
Neuronal activities drive brain waste clearance through the glymphatic system	67
Intestinal epithelial cell NCoR deficiency ameliorates obesity and metabolic syndrome	66
Discovery of a novel exceptionally potent and orally active Nur77 ligand NB1 with a distinct binding mode for cancer therapy	65
Microneedle-based devices for point-of-care infectious disease diagnostics	65
Reductive stress—a common metabolic feature of obesity and cancer	65
DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS‒STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis	65
Bioresponsive immune-booster-based prodrug nanogel for cancer immunotherapy	65
Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles and nanoemulsions: A current overview of in vivo studies	65
Oral delivery of proteins and peptides: Challenges, status quo and future perspectives	65
Antibody–drug conjugates: Recent advances in linker chemistry	64
PEGylated bacteria restore intestinal mucosal barrier	63
Role of CD8+ T lymphocyte cells: Interplay with stromal cells in tumor microenvironment	63
Abelmoschus manihot polysaccharide fortifies intestinal mucus barrier to alleviate intestinal inflammation by modulating Akkermansia muciniphila abundance	63
Cover Story	63
Decoding the chromatin accessibility in Andrographis paniculata genome, a case study of genome-wide investigation of the cis-regulatory elements in medicinal plants	62
Cathepsin B-responsive and gadolinium-labeled branched glycopolymer-PTX conjugate-derived nanotheranostics for cancer treatment	61
Extensive expansion of the chemical diversity of fusidane-type antibiotics using a stochastic combinational strategy	61
Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism	61
Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators	61
Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS	60
TRIB3 promotes pulmonary fibrosis through inhibiting SLUG degradation by physically interacting with MDM2	60
Drug discovery by targeting the protein–protein interactions involved in autophagy	59
A novel TNKS/USP25 inhibitor blocks the Wnt pathway to overcome multi-drug resistance in TNKS-overexpressing colorectal cancer	59
Repurposing carrimycin as an antiviral agent against human coronaviruses, including the currently pandemic SARS-CoV-2	58
Picomolar inhibitor of reverse transcriptase featuring significantly improved metabolic stability	58
A metabolic intervention strategy to break evolutionary adaptability of tumor for reinforced immunotherapy	58
A smart O2-generating nanocarrier optimizes drug transportation comprehensively for chemotherapy improving	57
Glycan targeting nanoparticle for photodynamic immunotherapy of melanoma	57
Cooperative coordination-mediated multi-component self-assembly of “all-in-one” nanospike theranostic nano-platform for MRI-guided synergistic therapy against breast cancer	57
Discovery of a potent and selective cell division cycle 7 inhibitor from 6-(3-fluoropyridin-4-yl)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as an orally active antitumor agent	56
A novel heterologous receptor-binding domain dodecamer universal mRNA vaccine against SARS-CoV-2 variants	56
Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin: Creation of an unnatural analogue with improved anticancer properties	56
Allosterically activating SHP2 by oleanolic acid inhibits STAT3–Th17 axis for ameliorating colitis	55
Deubiquitinase JOSD2 stabilizes YAP/TAZ to promote cholangiocarcinoma progression	55
MCDB: A comprehensive curated mitotic catastrophe database for retrieval, protein sequence alignment, and target prediction	55
Traditional Chinese medicine for the treatment of immune-related nephropathy: A review	55
Orange-derived extracellular vesicles nanodrugs for efficient treatment of ovarian cancer assisted by transcytosis effect	54
Evolution and development of potent monobactam sulfonate candidate IMBZ18g as a dual inhibitor against MDR Gram-negative bacteria producing ESBLs	54
Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk	54
Discovery of novel sulfonamide substituted indolylarylsulfones as potent HIV-1 inhibitors with better safety profiles	54
Tumor-targeted metabolic inhibitor prodrug labelled with cyanine dyes enhances immunoprevention of lung cancer	53
Environmental exposure as a risk-modifying factor in liver diseases: Knowns and unknowns	53
Discovery of a potent FKBP38 agonist that ameliorates HFD-induced hyperlipidemia via mTOR/P70S6K/SREBPs pathway	53
A redox-responsive self-assembling COA-4-arm PEG prodrug nanosystem for dual drug delivery suppresses cancer metastasis and drug resistance by downregulating hsp90 expression	52
Improving cancer immunotherapy via co-delivering checkpoint blockade and thrombospondin-1 downregulator	52
Stimuli-responsive nano vehicle enhances cancer immunotherapy by coordinating mitochondria-targeted immunogenic cell death and PD-L1 blockade	52
Self-assembling, pH-responsive nanoflowers for inhibiting PAD4 and neutrophil extracellular trap formation and improving the tumor immune microenvironment	52
Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors	51
Construction of acetyl-CoA and DBAT hybrid metabolic pathway for acetylation of 10-deacetylbaccatin III to baccatin III	51
Repurposing of berbamine hydrochloride to inhibit Ebola virus by targeting viral glycoprotein	51
PAFR/Stat3 axis maintains the symbiotic ecosystem between tumor and stroma to facilitate tumor malignancy	50
The role of E3 ubiquitin ligases in bone homeostasis and related diseases	49
The traditional Chinese medicines treat chronic heart failure and their main bioactive constituents and mechanisms	49
Advances and challenges in the treatment of esophageal cancer	49
Non-canonical STING–PERK pathway dependent epigenetic regulation of vascular endothelial dysfunction via integrating IRF3 and NF-κB in inflammatory response	49
Acid-switchable nanoparticles induce self-adaptive aggregation for enhancing antitumor immunity of natural killer cells	49
Intracellular aggregation of peptide-reprogrammed small molecule nanoassemblies enhances cancer chemotherapy and combinatorial immunotherapy	48
Free energy perturbation (FEP)-guided scaffold hopping	48
Current approaches of nanomedicines in the market and various stage of clinical translation	48
Design consideration of phthalocyanines as sensitizers for enhanced sono-photodynamic combinatorial therapy of cancer	48
“Pincer movement”: Reversing cisplatin resistance based on simultaneous glutathione depletion and glutathione S-transferases inhibition by redox-responsive degradable organosilica hybrid nanoparticles	48
Small-molecule agents for cancer immunotherapy	47
Exosomes derived from pulmonary metastatic sites enhance osteosarcoma lung metastasis by transferring the miR-194/215 cluster targeting MARCKS	47
Polymeric nanocarriers for nose-to-brain drug delivery in neurodegenerative diseases and neurodevelopmental disorders	47
Heliangin acts as a covalent ligand of RPS2 that disrupts pre-rRNA metabolic processes in NPM1-mutated acute myeloid leukemia	46
Intranasal temperature-sensitive hydrogels of cannabidiol inclusion complex for the treatment of post-traumatic stress disorder	46
Gains from no real PAINS: Where ‘Fair Trial Strategy’ stands in the development of multi-target ligands	46
Multi-omics approaches identify SF3B3 and SIRT3 as candidate autophagic regulators and druggable targets in invasive breast carcinoma	46
The raphe nuclei are the early lesion site of gastric α-synuclein propagation to the substantia nigra	46
Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for P53 activation and tumor suppression	45
Developmental toxicity and programming alterations of multiple organs in offspring induced by medication during pregnancy	45
SYNCRIP controls miR-137 and striatal learning in animal models of methamphetamine abstinence	45
Rhodojaponin VI indirectly targets Cav2.2 channels via N-ethylmaleimide-sensitive fusion protein to alleviate neuropathic pain	45
Recent developments in the medicinal chemistry of single boron atom-containing compounds	45

Anti-PD-L1 antibody enhances curative effect of cryoablation via antibody-dependent cell-mediated cytotoxicity mediating PD-L1highCD11b+ cells elimination in hepatocellular carcinoma	45
Small molecule α-methylene-γ-butyrolactone, an evolutionarily conserved moiety in sesquiterpene lactones, ameliorates arthritic phenotype via interference DNA binding activity of NF-κB	44
Gold nanoparticle-directed autophagy intervention for antitumor immunotherapy via inhibiting tumor-associated macrophage M2 polarization	44
Suppressing fatty acid synthase by type I interferon and chemical inhibitors as a broad spectrum anti-viral strategy against SARS-CoV-2	44
Sequential delivery of PD-1/PD-L1 blockade peptide and IDO inhibitor for immunosuppressive microenvironment remodeling via an MMP-2 responsive dual-targeting liposome	44
Extracellular vesicles: Emerging tools as therapeutic agent carriers	44
Highly sensitive H2O2-scavenging nano-bionic system for precise treatment of atherosclerosis	43
Phototriggered structures: Latest advances in biomedical applications	43
Recent advances in bacterial therapeutics based on sense and response	43
An update on oral drug delivery via intestinal lymphatic transport	42
Hollow copper sulfide nanoparticles carrying ISRIB for the sensitized photothermal therapy of breast cancer and brain metastases through inhibiting stress granule formation and reprogramming tumor‐ass	42
Metabolomics in drug research and development: The recent advances in technologies and applications	42
Bile acid coordinates microbiota homeostasis and systemic immunometabolism in cardiometabolic diseases	42
ETCM v2.0: An update with comprehensive resource and rich annotations for traditional Chinese medicine	42
Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways	41
Enzyme-instructed and mitochondria-targeting peptide self-assembly to efficiently induce immunogenic cell death	41
Azvudine reduces the in-hospital mortality of COVID-19 patients: A retrospective cohort study	41
Novel STING-targeted PET radiotracer for alert and therapeutic evaluation of acute lung injury	41
Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy	41
Targeting the blood–brain barrier to delay aging-accompanied neurological diseases by modulating gut microbiota, circadian rhythms, and their interplays	41
A novel inhibitor of N6-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities	41
Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions	41
Hepatic retinaldehyde deficiency is involved in diabetes deterioration by enhancing PCK1- and G6PC-mediated gluconeogenesis	41
Molecular glues modulate protein functions by inducing protein aggregation: A promising therapeutic strategy of small molecules for disease treatment	40
An injectable micelle-hydrogel hybrid for localized and prolonged drug delivery in the management of renal fibrosis	40
Gasdermin D-mediated pyroptosis in myocardial ischemia and reperfusion injury: Cumulative evidence for future cardioprotective strategies	40
Receptor-mediated targeted drug delivery systems for treatment of inflammatory bowel disease: Opportunities and emerging strategies	40
The phytochemical, biological, and medicinal attributes of phytoecdysteroids: An updated review	40
Discovery of an orally active VHL-recruiting PROTAC that achieves robust HMGCR degradation and potent hypolipidemic activity in vivo	39
Bile acid homeostasis in female mice deficient in Cyp7a1 and Cyp27a1	39
Therapeutic strategies of targeting non-apoptotic regulated cell death (RCD) with small-molecule compounds in cancer	39
Natural compounds modulate the autophagy with potential implication of stroke	39
Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation	39
CXCR6-based immunotherapy in autoimmune, cancer and inflammatory infliction	39
In vivo delivery of CRISPR-Cas9 therapeutics: Progress and challenges	39
Phosphorylation regulates cullin-based ubiquitination in tumorigenesis	39
Hepatotoxicity reports in the FDA adverse event reporting system database: A comparison of drugs that cause injury via mitochondrial or other mechanisms	39
Monoclonal antibodies and aptamers: The future therapeutics for Alzheimer's disease	39
Approved HIV reverse transcriptase inhibitors in the past decade	38
Author correction to “Development of small-molecule tropomyosin receptor kinase (TRK) inhibitors for NTRK fusion cancers” [Acta Pharmaceutica Sinica B 11 (2021) 355–372]	38
Gentiopicroside targets PAQR3 to activate the PI3K/AKT signaling pathway and ameliorate disordered glucose and lipid metabolism	38
Author correction to “A nanocleaner specifically penetrates the blood‒brain barrier at lesions to clean toxic proteins and regulate inflammation in Alzheimer’s disease” [Acta Pharmaceutica Sinica B 12	38
Author correction to ‘Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy’ [Acta Pharmaceutica Sinica B 11 (2021) 3508–3526]	38
Author correction to ‘Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA’ [Acta Pharmaceutica Sinica B 13 (2023) 2585–2600]	38
Nanomaterials evoke pyroptosis boosting cancer immunotherapy	38
Molecular basis of enhanced GLP-1 signaling mediated by GLP-1(9–36) in conjunction with LSN3318839	38
Two types of coumarins-specific enzymes complete the last missing steps in pyran- and furanocoumarins biosynthesis	38
miR-429-3p mediates memory decline by targeting MKP-1 to reduce surface GluA1-containing AMPA receptors in a mouse model of Alzheimer's disease	38
Author correction to ‘FGF4 protects the liver from immune-mediated injury by activating CaMKKβ-PINK1 signal pathway to inhibit hepatocellular apoptosis’ [Acta Pharm Sin B 14 (2024) 1605–1623]	38
A novel shark VNAR antibody-based immunotoxin targeting TROP-2 for cancer therapy	38
Neutralization of SARS-CoV-2 pseudovirus using ACE2-engineered extracellular vesicles	37
Co-delivery of nigericin and decitabine using hexahistidine-metal nanocarriers for pyroptosis-induced immunotherapeutics	37
Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice	37
Identification of anti-Mycobacterium tuberculosis agents targeting the interaction of bacterial division proteins FtsZ and SepFe	37
A retrospective cohort study of the efficacy and safety of oral azvudine versus nirmatrelvir/ritonavir in elderly hospitalized COVID-19 patients aged over 60 years	36
Akkermansia muciniphila-derived acetate activates the hepatic AMPK/SIRT1/PGC-1α axis to alleviate ferroptosis in metabolic-associated fatty liver disease	36
Boosting with Omicron-specific mRNA vaccine or historical SARS-CoV-2 vaccines elicits discriminating immune responses against Omicron variants	36
Discovery of a potential hematologic malignancies therapy: Selective and potent HDAC7 PROTAC degrader targeting non-enzymatic function	36
Identification of anthelmintic parbendazole as a therapeutic molecule for HNSCC through connectivity map-based drug repositioning	36
STK39 inhibits antiviral immune response by inhibiting DCAF1-mediated PP2A degradation	36
Synovial joints: The barometer of systemic inflammation	36
Screening potential P-glycoprotein inhibitors by combination of a detergent-free membrane protein extraction with surface plasmon resonance biosensor	35
Insights into therapeutic peptides in the cancer-immunity cycle: Update and challenges	35
Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis	35
Synergistic activation of AMPK by AdipoR1/2 agonist and inhibitor of EDPs–EBP interaction recover NAFLD through enhancing mitochondrial function in mice	34
Entinostat, a class I selective histone deacetylase inhibitor, plus exemestane for Chinese patients with hormone receptor-positive advanced breast cancer: A multicenter, randomized, double-blind, plac	34
Targeting FAPα-positive lymph node metastatic tumor cells suppresses colorectal cancer metastasis	34
SARS-CoV-2 ORF10 hijacking ubiquitination machinery reveals potential unique drug targeting sites	34
Antitumor activity of aumolertinib, a third-generation EGFR tyrosine kinase inhibitor, in non-small-cell lung cancer harboring uncommon EGFR mutations	34
Molecular glue triggers degradation of PHGDH by enhancing the interaction between DDB1 and PHGDH	34
Table of Contents	34
Editorial of Special Column on A New Era of Nanobiomaterial-based Drug Delivery	34
Table of Contents	34
Transepithelial transport of nanoparticles in oral drug delivery: From the perspective of surface and holistic property modulation	34
Five trends of China's pharmaceutical industry in 2022	34
Equisetin is an anti-obesity candidate through targeting 11β-HSD1	33
Lipid-polymer hybrid nanoparticle with cell-distinct drug release for treatment of stemness-derived resistant tumor	33
Chemical screen identifies shikonin as a broad DNA damage response inhibitor that enhances chemotherapy through inhibiting ATM and ATR	33
The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation	33
The Ca2+-activated chloride channel ANO1/TMEM16A: An emerging therapeutic target for epithelium-originated diseases?	33
Commentary: Can FXR serve as a potential target for COVID-19 prevention?	33
Commentary: Mammokine directs beige adipocytes to reserve energy for milk production in breast	32
Artemisinin and artemisinin derivatives as anti-fibrotic therapeutics	32
IKKβ mediates homeostatic function in inflammation via competitively phosphorylating AMPK and IκBα	32
Inhaled curcumin mesoporous polydopamine nanoparticles against radiation pneumonitis	32
A review of existing strategies for designing long-acting parenteral formulations: Focus on underlying mechanisms, and future perspectives	32
Editor Profiles: Guest Editors of Special Column “Novel Peptides and Peptidomimetics in Drug Discovery”	32
Engineering cannabidiol synergistic carbon monoxide nanocomplexes to enhance cancer therapy via excessive autophagy	31
Reactive oxygen species and nitric oxide scavenging nanoparticles alleviating rheumatoid arthritis through adjusting the seeds and growing soils	31
Editorial of Special Issue “The Biological Fate of Drug Nanocarriers”	31
Fluorine-thiol displacement probes for acetaminophen's hepatotoxicity	31
Structure-based drug discovery of novel fused-pyrazolone carboxamide derivatives as potent and selective AXL inhibitors	31
Editor Profile: Guest Editor of Special Column on RNA Therapeutics and Drug Delivery Technologies for Medical Applications	31
Mechanistic studies of PEG-asparaginase-induced liver injury and hepatic steatosis in mice	31
Cover Story	31