Acta Pharmaceutica Sinica B

Article	Citations
A novel heterologous receptor-binding domain dodecamer universal mRNA vaccine against SARS-CoV-2 variants	851
Discovery and mechanism verification of first-in-class hydrophobic tagging-based degraders of HBV core protein	422
Editorial of Special Column “Novel Peptides and Peptidomimetics in Drug Discovery”	353
Drug discovery in China: A snapshot of recent progress	347
Research and development of Chinese anti-COVID-19 drugs	340
Sequential dual-locking strategy using photoactivated Pt(IV)-based metallo-nano prodrug for enhanced chemotherapy and photodynamic efficacy by triggering ferroptosis and macrophage polarization	318
[18F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models	313
Decoding the chromatin accessibility in Andrographis paniculata genome, a case study of genome-wide investigation of the cis-regulatory elements in medicinal plants	243
Extensive expansion of the chemical diversity of fusidane-type antibiotics using a stochastic combinational strategy	239
Identification of a JAK–STAT–miR155HG positive feedback loop in regulating natural killer (NK) cells proliferation and effector functions	234
Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk	209
Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer	207
Discovery and development of brain-penetrant 18F-labeled radioligands for neuroimaging of the sigma-2 receptors	205
Reductive stress—a common metabolic feature of obesity and cancer	205
Reconstitution of biosynthetic pathway for mushroom-derived cyathane diterpenes in yeast and generation of new “non-natural” analogues	203
Spatial metabolomics highlights metabolic reprogramming in acute myeloid leukemia mice through creatine pathway	202
Multi-omics approaches identify SF3B3 and SIRT3 as candidate autophagic regulators and druggable targets in invasive breast carcinoma	196
Akkermansia muciniphila-derived acetate activates the hepatic AMPK/SIRT1/PGC-1α axis to alleviate ferroptosis in metabolic-associated fatty liver disease	194
Allosterically activating SHP2 by oleanolic acid inhibits STAT3–Th17 axis for ameliorating colitis	185
A novel shark VNAR antibody-based immunotoxin targeting TROP-2 for cancer therapy	182
Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions	182
Spirohypertones A and B as potent antipsoriatics: Tumor necrosis factor-α inhibitors with unprecedented chemical architectures	180
Regulation of histidine metabolism by Lactobacillus Reuteri mediates the pathogenesis and treatment of ischemic stroke	177
Novel carbazole attenuates vascular remodeling through STAT3/CIAPIN1 signaling in vascular smooth muscle cells	175
Lycorine hydrochloride directly targets UBA1 to suppress cellular senescence	169

Gasdermin D-mediated pyroptosis in myocardial ischemia and reperfusion injury: Cumulative evidence for future cardioprotective strategies	166
Free energy perturbation (FEP)-guided scaffold hopping	165
MCDB: A comprehensive curated mitotic catastrophe database for retrieval, protein sequence alignment, and target prediction	164
Identification of anti-Mycobacterium tuberculosis agents targeting the interaction of bacterial division proteins FtsZ and SepFe	160
Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy	159
Two types of coumarins-specific enzymes complete the last missing steps in pyran- and furanocoumarins biosynthesis	153
Unravelling the target landscape of tranylcypromines for new drug discovery	147
A novel inhibitor of N6-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities	140
Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin: Creation of an unnatural analogue with improved anticancer properties	140
Role of CD8+ T lymphocyte cells: Interplay with stromal cells in tumor microenvironment	138
PAFR/Stat3 axis maintains the symbiotic ecosystem between tumor and stroma to facilitate tumor malignancy	136
Coating with flexible DNA network enhanced T-cell activation and tumor killing for adoptive cell therapy	132
Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia	130
Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice	128
Functional identification of the terpene synthase family involved in diterpenoid alkaloids biosynthesis in Aconitum carmichaelii	124
Azvudine reduces the in-hospital mortality of COVID-19 patients: A retrospective cohort study	124
Transformation of peptides to small molecules in medicinal chemistry: Challenges and opportunities	121
Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles	115
Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism	114
An update on oral drug delivery via intestinal lymphatic transport	114
Editor Profile: Guest Editor of Special Column on RNA Therapeutics and Drug Delivery Technologies for Medical Applications	113
Five trends of China's pharmaceutical industry in 2022	112
Cover Story	111
FOXO3 mutation predicting gefitinib-induced hepatotoxicity in NSCLC patients through regulation of autophagy	110
Structure-based drug discovery of novel fused-pyrazolone carboxamide derivatives as potent and selective AXL inhibitors	109
Recent advances in developing small-molecule inhibitors against SARS-CoV-2	108
Remembering your A, B, C's: Alzheimer's disease and ABCA1	107
Nanoparticle drug delivery system for the treatment of brain tumors: Breaching the blood–brain barrier	106
Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy	105
Nanoparticles (NPs)-mediated lncBCMA silencing to promote eEF1A1 ubiquitination and suppress breast cancer growth and metastasis	104
“Weibing” in traditional Chinese medicine—biological basis and mathematical representation of disease-susceptible state	104
A preclinical and first-in-human study of superstable homogeneous radiolipiodol for revolutionizing interventional diagnosis and treatment of hepatocellular carcinoma	101
Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells	100
Commentary: The central lymphatic drainage in pharmacological, surgical and physical therapies of Alzheimer's disease	100
Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in non-alcoholic steatohepatitis patients	99
Bimetallic nanoparticles as cascade sensitizing amplifiers for low-dose and robust cancer radio-immunotherapy	96
The role of bacteria and its derived biomaterials in cancer radiotherapy	93
Energy metabolism disorders and potential therapeutic drugs in heart failure	92
Free fatty acid receptor-4 regulates T-cell-mediated allogeneic reaction through activating an aryl hydrocarbon receptor pathway	91
Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis	91
Transferrin receptor-targeted immunostimulant for photodynamic immunotherapy against metastatic tumors through β-catenin/CREB interruption	90
Melatonin alleviates alcoholic liver disease via EGFR–BRG1–TERT axis regulation	90
NIR-II-activated whole-cell vaccine with ultra-efficient semiconducting diradical oligomers for breast carcinoma growth and metastasis inhibition	90
The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation	90
Unlocking T cell exhaustion: Insights and implications for CAR-T cell therapy	89
Suppressing Wnt signaling of the blood‒tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases	87
Astaxanthine attenuates cisplatin ototoxicity in vitro and protects against cisplatin-induced hearing loss in vivo	87
GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer	86
Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation	86
Therapeutic potential of traditional Chinese medicine for the treatment of NAFLD: A promising drug Potentilla discolor Bunge	84

Insights into therapeutic peptides in the cancer-immunity cycle: Update and challenges	84
Development of Chinese herbal medicine for sensorineural hearing loss	82
Engineered nanoparticles for precise targeted drug delivery and enhanced therapeutic efficacy in cancer immunotherapy	81
Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein (RNP) to inhibit herpes simplex virus1 infection in vitro and in vivo	81
The influence of the gut microbiota on the bioavailability of oral drugs	78
Targeting the Warburg effect: A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer	78
Immune cell membrane-based biomimetic nanomedicine for treating cancer metastasis	77
Mitochondrial transplantation as a promising therapy for mitochondrial diseases	76
Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease	76
Exemplifying interspecies variation of liposome in vivo fate by the effects of anti-PEG antibodies	76
Adipose ADM2 ameliorates NAFLD via promotion of ceramide catabolism	75
Table of Contents	75
JAK inhibition ameliorated experimental autoimmune encephalomyelitis by blocking GM-CSF-driven inflammatory signature of monocytes	75
Logic-gated tumor-microenvironment nanoamplifier enables targeted delivery of CRISPR/Cas9 for multimodal cancer therapy	74
The chromosome-scale assembly of the Notopterygium incisum genome provides insight into the structural diversity of coumarins	74
The role of botanical triterpenoids and steroids in bile acid metabolism, transport, and signaling: Pharmacological and toxicological implications	74
Inhibiting collagen I production and tumor cell colonization in the lung via miR-29a-3p loading of exosome-/liposome-based nanovesicles	73
Unveiling nonribosomal peptide synthetases from the ergot fungus Claviceps purpurea involved in the formation of diverse ergopeptines	73
Intravenous delivery of STING agonists using acid-sensitive polycationic polymer-modified lipid nanoparticles for enhanced tumor immunotherapy	73
Dihydromyricetin mitigates abdominal aortic aneurysm via transcriptional and post-transcriptional regulation of heme oxygenase-1 in vascular smooth muscle cells	73
Cell membrane-derived vesicles for delivery of therapeutic agents	72
PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism	72
Optical substrates for drug-metabolizing enzymes: Recent advances and future perspectives	71
Nanoparticles with rough surface improve the therapeutic effect of photothermal immunotherapy against melanoma	71
Colon-specific controlled release of oral liposomes for enhanced chemo-immunotherapy against colorectal cancer	70
Unveiling ferroptosis as a promising therapeutic avenue for colorectal cancer and colitis treatment	70
Recent advances to address challenges in extracellular vesicle-based applications for lung cancer	70
Viral miRNA-mediated activation of hyaluronan production as a drug target against COVID-19	69
KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer	69
Advances in development of antiviral strategies against respiratory syncytial virus	68
ROS-degradable polythioketal urethane scaffold for porcine wound repair	68
Hyperglycemia activates FGFR1 via TLR4/c-Src pathway to induce inflammatory cardiomyopathy in diabetes	68
Recent advances in the bench-to-bedside translation of cancer nanomedicines	67
Topical adhesive spatio-temporal nanosystem co-delivering chlorin e6 and HMGB1 inhibitor glycyrrhizic acid for in situ psoriasis chemo-phototherapy	66
Synergistic metabolic modulation of fibroblast-like synoviocytes via targeted dual prodrug nanoparticles to mitigate rheumatoid arthritis	66
Safety, dosimetry, and efficacy of an optimized long-acting somatostatin analog for peptide receptor radionuclide therapy in metastatic neuroendocrine tumors: From preclinical testing to first-in-huma	66
Antrodia cinnamomea exerts an anti-hepatoma effect by targeting PI3K/AKT-mediated cell cycle progression in vitro and in vivo	65
Pharmacological modulation of autophagy for Alzheimer's disease therapy: Opportunities and obstacles	64
A neutrophil-biomimic platform for eradicating metastatic breast cancer stem-like cells by redox microenvironment modulation and hypoxia-triggered differentiation therapy	63
Biomimetic nanomedicines for precise atherosclerosis theranostics	63
Actively separated microneedle patch for sustained-release of growth hormone to treat growth hormone deficiency	63
Cholinergic dysfunction-induced insufficient activation of alpha7 nicotinic acetylcholine receptor drives the development of rheumatoid arthritis through promoting protein citrullination via the SP3/P	63
PKCα inhibitors promote breast cancer immune evasion by maintaining PD-L1 stability	63
Charge-guided masking of a membrane-destabilizing peptide enables efficient endosomal escape for targeted intracellular delivery of proteins	63
Table of Contents	63
Metal nanoparticles for cancer therapy: Precision targeting of DNA damage	63
Regulating the microenvironment with nanomaterials: Potential strategies to ameliorate COVID-19	62
Erratum to “Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis” [Acta Pharm Sin B 14 (2024) 3493–3512]	61
Antitumor activity and low gastrointestinal toxicity of a novel selective inhibitor of nuclear export, SZJK-0421, in multiple myeloma	61
DNA origami nanodevice with spatial regulation of CD95 signaling for rheumatoid arthritis treatment	61
Microglial APOE4 promotes neuron degeneration in Alzheimer's disease through inhibition of lipid droplet autophagy	61
Discovery of a novel thiophene carboxamide analogue as a highly potent and selective sphingomyelin synthase 2 inhibitor for dry eye disease therapy	61
Oral garlic-derived nanoparticles improve cancer immunotherapy	61
Structure-based design and optimization lead to the identification of novel dihydrothiopyrano[3,2-d]pyrimidine derivatives as potent HIV-1 inhibitors against drug-resistant variants	60
Bioorthogonal microglia-inspired mesenchymal stem cell bioengineering system creates livable niches for enhancing ischemic stroke recovery via the hormesis	60
Nature's marvels endowed in gaseous molecules I: Carbon monoxide and its physiological and therapeutic roles	60
A chromosome-level Dendrobium moniliforme genome assembly reveals the regulatory mechanisms of flavonoid and carotenoid biosynthesis pathways	59
MicroRNA-34c-5p provokes isoprenaline-induced cardiac hypertrophy by modulating autophagy via targeting ATG4B	59
DNA-PK inhibition by M3814 enhances chemosensitivity in non-small cell lung cancer	59
Pancreatic melatonin enhances anti-tumor immunity in pancreatic adenocarcinoma through regulating tumor-associated neutrophils infiltration and NETosis	59
Cell-derived nanovesicles from mesenchymal stem cells as extracellular vesicle-mimetics in wound healing	59
FGF4 protects the liver from immune-mediated injury by activating CaMKKβ-PINK1 signal pathway to inhibit hepatocellular apoptosis	58
Precise assembly of inside-out cell membrane camouflaged nanoparticles via bioorthogonal reactions for improving drug leads capturing	58
Selectively T cell phosphorylation activation of azvudine in the thymus tissue with immune protection effect	58
Comparative genomic analysis of esophageal squamous cell carcinoma and adenocarcinoma: New opportunities towards molecularly targeted therapy	58
Psychological stress-activated NR3C1/NUPR1 axis promotes ovarian tumor metastasis	58
Deubiquitination complex platform: A plausible mechanism for regulating the substrate specificity of deubiquitinating enzymes	58
A hybrid bacterium with tumor-associated macrophage polarization for enhanced photothermal-immunotherapy	57
Escape from abluminal LRP1-mediated clearance for boosted nanoparticle brain delivery and brain metastasis treatment	57
TPGS/hyaluronic acid dual-functionalized PLGA nanoparticles delivered through dissolving microneedles for markedly improved chemo-photothermal combined therapy of superficial tumor	57
Ruscogenin alleviates LPS-triggered pulmonary endothelial barrier dysfunction through targeting NMMHC IIA to modulate TLR4 signaling	57
Bladder microenvironment actuated proteomotors with ammonia amplification for enhanced cancer treatment	56
Dual-responsive nanoparticles with transformable shape and reversible charge for amplified chemo-photodynamic therapy of breast cancer	56
Pharmaceutical strategies to extend pulmonary exposure of inhaled medicines	56
Emerging delivery systems based on aqueous two-phase systems: A review	56
Engineering nanomedicines for immunogenic eradication of cancer cells: Recent trends and synergistic approaches	56
Dual-responsive supramolecular photodynamic nanomedicine with activatable immunomodulation for enhanced antitumor therapy	55
Emerging trends in organ-on-a-chip systems for drug screening	55
Amelioration of ethanol-induced oxidative stress and alcoholic liver disease by in vivo RNAi targeting Cyp2e1	54
Transient induction of actin cytoskeletal remodeling associated with dedifferentiation, proliferation, and redifferentiation stimulates cardiac regeneration	54

Extracellular vesicles from human urine-derived stem cells delay aging through the transfer of PLAU and TIMP1	54
Table of Contents	53
A micro-sized vaccine based on recombinant Lactiplantibacillus plantarum fights against SARS-CoV-2 infection via intranasal immunization	53
Cover Story	52
Cover Story	52
Editorial of Special Issue of Hot Topic Reviews in Drug Delivery	52
Cover Story	52
Table of Contents	52
Author correction to ‘Ruscogenin alleviates LPS-triggered pulmonary endothelial barrier dysfunction through targeting NMMHC IIA to modulate TLR4 signaling’ [Acta Pharmaceutica Sinica B 12 (2022) 1198–	51
WITHDRAWN: A neurovascular dual-targeting platelet-like bioinspired nanoplatform for ischemic stroke treatment	51
Identification of human LDHC4 as a potential target for anticancer drug discovery	51
Nature-inspired supramolecular assemblies for precise biomedical imaging and therapy	51
Advancements and challenges in immunocytokines: A new arsenal against cancer	51
Author correction to ‘Bioengineered miR-124-3p prodrug selectively alters the proteome of human carcinoma cells to control multiple cellular components and lung metastasis in vivo’ [Acta Pharmaceutica	50
Celastrol directly targets LRP1 to inhibit fibroblast-macrophage crosstalk and ameliorates psoriasis progression	50
Harnessing the UDP-G/P2Y14R axis to promote liver regeneration in acute liver failure	50
Cover Story	50
Author correction to “PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism” [Acta Pharm Sin B 13 (2023) 157–173]	50
Discovery of highly potent phosphodiesterase-1 inhibitors by a combined-structure free energy perturbation approach	49
Avenanthramide A potentiates Bim-mediated antineoplastic properties of 5-fluorouracil via targeting KDM4C/MIR17HG/GSK-3β negative feedback loop in colorectal cancer	49
Inhibition of CCT5-mediated asparagine biosynthesis and anti-PD-L1 produce synergistic antitumor effects in colorectal cancer	48
The cellular immunotherapy of integrated photothermal anti-oxidation Pd–Se nanoparticles in inhibition of the macrophage inflammatory response in rheumatoid arthritis	48
Single-domain antibodies as therapeutics for solid tumor treatment	47
Unlocking the potential of the gut microbiome in liver regeneration: Benefits and mechanistic insights	47
Multi-functional vesicles improve Helicobacter pylori eradication by a comprehensive strategy based on complex pathological microenvironment	47
Analysis of new drug registration and review in China in 2021	47
The ubiquitin–proteasome system: A potential target for the MASLD	47
Discovery of novel exceptionally potent and orally active c-MET PROTACs for the treatment of tumors with MET alterations	47
The novel ER stress inducer Sec C triggers apoptosis by sulfating ER cysteine residues and degrading YAP via ER stress in pancreatic cancer cells	47
Personalized medicine of non-gene-specific chemotherapies for non-small cell lung cancer	47
Targeting RAF dimers in RAS mutant tumors: From biology to clinic	46
Discovery of novel 4-phenylquinazoline-based BRD4 inhibitors for cardiac fibrosis	46
Imaging the impact of sex and age on OATP function in humans: Consequences for whole-body pharmacokinetics and liver exposure	46
Mucosal delivery of nanovaccine strategy against COVID-19 and its variants	46
Novel compound FLZ alleviates rotenone-induced PD mouse model by suppressing TLR4/MyD88/NF-κB pathway through microbiota–gut–brain axis	46
Selective type II TRK inhibitors overcome xDFG mutation mediated acquired resistance to the second-generation inhibitors selitrectinib and repotrectinib	46
Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls	45
High-throughput discovery of highly selective reversible hMAO-B inhibitors based on at-line nanofractionation	45
mIgM-mediated splenic marginal zone B cells targeting of folic acid for immunological evasion	45
Spatial-resolved metabolomics reveals tissue-specific metabolic reprogramming in diabetic nephropathy by using mass spectrometry imaging	45
Precise nano-system-based drug delivery and synergistic therapy against androgen receptor-positive triple-negative breast cancer	45
Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management	44
Unveiling the metabolic fate of drugs through metabolic reaction-based molecular networking	44
Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis	44
Targeting BMI-1-mediated epithelial–mesenchymal transition to inhibit colorectal cancer liver metastasis	44
PROTAC technology as a novel tool to identify the target of lathyrane diterpenoids	44
Rhizoma Drynariae-derived nanovesicles reverse osteoporosis by potentiating osteogenic differentiation of human bone marrow mesenchymal stem cells via targeting ERα signaling	44
Translating bacteriophage-derived depolymerases into antibacterial therapeutics: Challenges and prospects	44
Spatiotemporally responsive cascade bilayer microneedles integrating local glucose depletion and sustained nitric oxide release for accelerated diabetic wound healing	44
Cover Story	43
“Relative symmetry with electronegativity of different key-groups” strategy for MRGPRX2 antagonist design and its effect on antigen-induced pulmonary inflammation	43
Non-apoptotic cell death-based cancer therapy: Molecular mechanism, pharmacological modulators, and nanomedicine	43
Locally producing antibacterial peptide to deplete intratumoral pathogen for preventing metastatic breast cancer	43
Cover Story	43
Bile acids and coronavirus disease 2019	42
Dissecting the novel abilities of aripiprazole: The generation of anti-colorectal cancer effects by targeting Gαq via HTR2B	42
AKR1C1 interacts with STAT3 to increase intracellular glutathione and confers resistance to oxaliplatin in colorectal cancer	42
Transcription factor EHF interacting with coactivator AJUBA aggravates malignancy and acts as a therapeutic target for gastroesophageal adenocarcinoma	42
l-[5-11C]Glutamine PET imaging noninvasively tracks dynamic responses of glutaminolysis in non-alcoholic steatohepatitis	42
Genome editing of PAR2 through targeted delivery of CRISPR-Cas9 system for alleviating acute lung inflammation via ERK/NLRP3/IL-1β and NO/iNOS signalling	42
Amylovis-201 is a new dual-target ligand, acting as an anti-amyloidogenic compound and a potent agonist of the σ1 chaperone protein	41
Controlling antifungal activity with light: Optical regulation of fungal ergosterol biosynthetic pathway with photo-responsive CYP51 inhibitors	41
Target-responsive subcellular catabolism analysis for early-stage antibody–drug conjugates screening and assessment	41
Targeting toll-like receptor 7 as a therapeutic development strategy for systemic lupus erythematosus	41
Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis	41
Author correction to “Tumor-microenvironment activated duplex genome-editing nanoprodrug for sensitized near-infrared titania phototherapy” [Acta Pharm Sin B (2022) 4224–4234]	41
Tranexamic acid-fatty alcohol polyoxyethylene ether conjugation/PVA foam for venous sclerotherapy via vascular damage and inhibiting plasmin system	41
Recent advances in reactive oxygen species (ROS)-responsive drug delivery systems for photodynamic therapy of cancer	40
Remodeling of the liver fibrosis microenvironment based on nilotinib-loaded multicatalytic nanozymes with boosted antifibrogenic activity	40
Bone-derived MSCs encapsulated in alginate hydrogel prevent collagen-induced arthritis in mice through the activation of adenosine A2A/2B receptors in tolerogenic dendritic cells	40
A multidimensional platform of patient-derived tumors identifies drug susceptibilities for clinical lenvatinib resistance	40
In vitro and in vivo correlation for lipid-based formulations: Current status and future perspectives	40
Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy	39
Development of a bacteria-nanosapper for the active delivery of ZIF-8 particles containing therapeutic genes for cancer immune therapy	39
One-step synthesis of site-specific antibody–drug conjugates by reprograming IgG glycoengineering with LacNAc-based substrates	39
Intelligent lesion blood–brain barrier targeting nano-missiles for Alzheimer's disease treatment by anti-neuroinflammation and neuroprotection	39
Effects of small molecules on neurogenesis: Neuronal proliferation and differentiation	39
Spatiotemporally resolved metabolomics and isotope tracing reveal CNS drug targets	39
Alleviating experimental pulmonary hypertension via co-delivering FoxO1 stimulus and apoptosis activator to hyperproliferating pulmonary arteries	39
Structures and functions of the MICOS: Pathogenesis and therapeutic implications in Alzheimer's disease	38
Full-profile pharmacokinetics, anticancer activity and toxicity of an extended release trivalent PEGylated irinotecan prodrug	38
Milk-derived exosomes exhibit versatile effects for improved oral drug delivery	38
Artificial intelligence in drug development for delirium and Alzheimer’s disease	38
Mucosal vaccine delivery: A focus on the breakthrough of specific barriers	37
Macrophage P2Y6R activation aggravates psoriatic inflammation through IL-27-mediated Th1 responses	37
Recent progress of aptamer‒drug conjugates in cancer therapy	37
Small molecule-based immunomodulators for cancer therapy	37
ACAT1 deficiency in myeloid cells promotes glioblastoma progression by enhancing the accumulation of myeloid-derived suppressor cells	37
Benzimidazole and its derivatives as cancer therapeutics: The potential role from traditional to precision medicine	37
Table of Contents	37
Prediction of lipid nanoparticles for mRNA vaccines by the machine learning algorithm	37
Author correction to ‘Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy’ [Acta Pharmaceutica Sinica B 11 (2021) 3508–3526]	36
Nanomaterials evoke pyroptosis boosting cancer immunotherapy	36
Author correction to ‘Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA’ [Acta Pharmaceutica Sinica B 13 (2023) 2585–2600]	36
Activation of PXR causes drug interactions with Paxlovid in transgenic mice	36