Acta Pharmaceutica Sinica B

Article	Citations
Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods	1513
Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites	492
Why 90% of clinical drug development fails and how to improve it?	333
Gasdermin D in pyroptosis	264
Long non-coding RNAs: From disease code to drug role	241
Crystal structure of SARS-CoV-2 papain-like protease	198
The biology, function, and applications of exosomes in cancer	198
Metal-organic frameworks for advanced drug delivery	194
Probiotics modulate the microbiota–gut–brain axis and improve memory deficits in aged SAMP8 mice	191
Mitochondrial quality control mechanisms as molecular targets in cardiac ischemia–reperfusion injury	187
Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies	179
The role of tumor-associated macrophages (TAMs) in tumor progression and relevant advance in targeted therapy	175
Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma	172
Potential therapeutic effects of dipyridamole in the severely ill patients with COVID-19	165
Recent progress of hypoxia-modulated multifunctional nanomedicines to enhance photodynamic therapy: opportunities, challenges, and future development	158
Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways	146
Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway	145
Targeting autophagy-related protein kinases for potential therapeutic purpose	138
Evolution of blood–brain barrier in brain diseases and related systemic nanoscale brain-targeting drug delivery strategies	133
Bioactive natural compounds against human coronaviruses: a review and perspective	131
Therapeutic strategies for the costimulatory molecule OX40 in T-cell-mediated immunity	127
Traditional Chinese medicine in COVID-19	126
Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis	123
New opportunities and challenges of natural products research: When target identification meets single-cell multiomics	121
Oral delivery of proteins and peptides: Challenges, status quo and future perspectives	119

Recent advances in drug delivery systems for targeting cancer stem cells	118
Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management	118
The progress and perspective of nanoparticle-enabled tumor metastasis treatment	116
Ginsenosides in Panax genus and their biosynthesis	115
Small interfering RNA for cancer treatment: overcoming hurdles in delivery	114
Antibody–drug conjugates: Recent advances in linker chemistry	113
Combating COVID-19 with integrated traditional Chinese and Western medicine in China	112
Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles and nanoemulsions: A current overview of in vivo studies	112
Doxorubicin-loaded bacterial outer-membrane vesicles exert enhanced anti-tumor efficacy in non-small-cell lung cancer	112
Alterations of DNA damage response pathway: Biomarker and therapeutic strategy for cancer immunotherapy	111
Pharmaceutical cocrystals: A review of preparations, physicochemical properties and applications	109
Identifying potential anti-COVID-19 pharmacological components of traditional Chinese medicine Lianhuaqingwen capsule based on human exposure and ACE2 biochromatography screening	105
Pulmonary delivery of siRNA against acute lung injury/acute respiratory distress syndrome	102
Current approaches of nanomedicines in the market and various stage of clinical translation	102
Synergetic delivery of triptolide and Ce6 with light-activatable liposomes for efficient hepatocellular carcinoma therapy	102
Recent advances of antibody drug conjugates for clinical applications	99
Epigenetic strategies synergize with PD-L1/PD-1 targeted cancer immunotherapies to enhance antitumor responses	99
Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis	98
Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses	96
Natural exosome-like nanovesicles from edible tea flowers suppress metastatic breast cancer via ROS generation and microbiota modulation	95
Advances and challenges in the treatment of esophageal cancer	94
Influencing factors and strategies of enhancing nanoparticles into tumors in vivo	93
The influence of the gut microbiota on the bioavailability of oral drugs	93
Analysis on herbal medicines utilized for treatment of COVID-19	93
In vivo delivery of CRISPR-Cas9 therapeutics: Progress and challenges	93
Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1	93
Protective role of berberine on ulcerative colitis through modulating enteric glial cells–intestinal epithelial cells–immune cells interactions	93
Biological drug and drug delivery-mediated immunotherapy	92
Gene therapy for neurodegenerative disorders: advances, insights and prospects	91
Recent advances in drug delivery applications of cubosomes, hexosomes, and solid lipid nanoparticles	90
Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5	90
Self-assembled natural phytochemicals for synergistically antibacterial application from the enlightenment of traditional Chinese medicine combination	90
Angiotensin-converting enzyme 2 (ACE2): SARS-CoV-2 receptor and RAS modulator	87
The cGAS–STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy	85
Monoacylglycerol lipase inhibitors: modulators for lipid metabolism in cancer malignancy, neurological and metabolic disorders	82
Recent developments on PET radiotracers for TSPO and their applications in neuroimaging	81
Exploration and insights into the cellular internalization and intracellular fate of amphiphilic polymeric nanocarriers	81
Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1	78
Nanomedicine-based drug delivery towards tumor biological and immunological microenvironment	77
Integrins as attractive targets for cancer therapeutics	77
Bone marrow mesenchymal stem cells-derived exosomes for penetrating and targeted chemotherapy of pancreatic cancer	77
Recent development on COX-2 inhibitors as promising anti-inflammatory agents: The past 10 years	77
Development of non-nucleoside reverse transcriptase inhibitors (NNRTIs): our past twenty years	76
Cell membrane-derived vesicles for delivery of therapeutic agents	76
Targeted nanomedicines remodeling immunosuppressive tumor microenvironment for enhanced cancer immunotherapy	75
An update on oral drug delivery via intestinal lymphatic transport	73
Emerging role of natural products in cancer immunotherapy	73
Ginsenoside Rg1 ameliorates blood–brain barrier disruption and traumatic brain injury via attenuating macrophages derived exosomes miR-21 release	72
GSH-sensitive polymeric prodrug: Synthesis and loading with photosensitizers as nanoscale chemo-photodynamic anti-cancer nanomedicine	71
Nanomedicine for acute respiratory distress syndrome: The latest application, targeting strategy, and rational design	71

Recent developments in the medicinal chemistry of single boron atom-containing compounds	70
Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation	69
Recent progress in sono-photodynamic cancer therapy: From developed new sensitizers to nanotechnology-based efficacy-enhancing strategies	68
Recent advances in nanomedicines for the treatment of ischemic stroke	67
Cathepsin B-responsive and gadolinium-labeled branched glycopolymer-PTX conjugate-derived nanotheranostics for cancer treatment	66
Symphony of nanomaterials and immunotherapy based on the cancer–immunity cycle	66
The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatment	66
Carbohydrate-based drugs launched during 2000−2021	65
Natural products as LSD1 inhibitors for cancer therapy	65
Selective inhibition of CDK4/6: A safe and effective strategy for developing anticancer drugs	65
Bioresponsive immune-booster-based prodrug nanogel for cancer immunotherapy	64
Nanomedicines modulating tumor immunosuppressive cells to enhance cancer immunotherapy	64
Development of small-molecule tropomyosin receptor kinase (TRK) inhibitors for NTRK fusion cancers	64
Delivery strategies for macromolecular drugs in cancer therapy	62
Pure drug nano-assemblies: A facile carrier-free nanoplatform for efficient cancer therapy	62
A cyclodextrin-based nanoformulation achieves co-delivery of ginsenoside Rg3 and quercetin for chemo-immunotherapy in colorectal cancer	62
Pharmaceutical strategies to extend pulmonary exposure of inhaled medicines	61
GSH-responsive SN38 dimer-loaded shape-transformable nanoparticles with iRGD for enhancing chemo-photodynamic therapy	61
A comprehensive review of integrative pharmacology-based investigation: A paradigm shift in traditional Chinese medicine	60
The role of lysosome in regulated necrosis	60
Cell membrane coated-nanoparticles for cancer immunotherapy	60
D3Targets-2019-nCoV: a webserver for predicting drug targets and for multi-target and multi-site based virtual screening against COVID-19	60
Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies	59
Targeted delivery of hyaluronic acid nanomicelles to hepatic stellate cells in hepatic fibrosis rats	59
Insight into chemical basis of traditional Chinese medicine based on the state-of-the-art techniques of liquid chromatography−mass spectrometry	58
Platinum complexes of curcumin delivered by dual-responsive polymeric nanoparticles improve chemotherapeutic efficacy based on the enhanced anti-metastasis activity and reduce side effects	58
Self-assembled small molecule natural product gel for drug delivery: a breakthrough in new application of small molecule natural products	56
Disturbed Yin–Yang balance: stress increases the susceptibility to primary and recurrent infections of herpes simplex virus type 1	56
Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators	56
Impairment of the autophagy–lysosomal pathway in Alzheimer's diseases: Pathogenic mechanisms and therapeutic potential	56
Rational drug design, synthesis, and biological evaluation of novel chiral tetrahydronaphthalene-fused spirooxindole as MDM2-CDK4 dual inhibitor against glioblastoma	55
Receptor-mediated targeted drug delivery systems for treatment of inflammatory bowel disease: Opportunities and emerging strategies	55
Nanomedicines for the treatment of rheumatoid arthritis: State of art and potential therapeutic strategies	55
Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway	55
A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis	54
Delivery strategies of amphotericin B for invasive fungal infections	54
SIRT6 as a key event linking P53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation	54
Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology: Implications for Alzheimer's disease therapy	54
SUV39H1 deficiency suppresses clear cell renal cell carcinoma growth by inducing ferroptosis	54
Membrane-disruptive peptides/peptidomimetics-based therapeutics: Promising systems to combat bacteria and cancer in the drug-resistant era	53
A review of existing strategies for designing long-acting parenteral formulations: Focus on underlying mechanisms, and future perspectives	53
Small-molecule MDM2/X inhibitors and PROTAC degraders for cancer therapy: advances and perspectives	53
Targeting autophagy using small-molecule compounds to improve potential therapy of Parkinson's disease	53
Targeting necroptosis in anticancer therapy: mechanisms and modulators	53
Opportunities and challenges of three-dimensional printing technology in pharmaceutical formulation development	53
Emerging vaccine nanotechnology: From defense against infection to sniping cancer	52
Target-based anticancer indole derivatives and insight into structure‒activity relationship: A mechanistic review update (2018–2021)	52
The chromosome-level reference genome assembly for Dendrobium officinale and its utility of functional genomics research and molecular breeding study	52
Spatial-resolved metabolomics reveals tissue-specific metabolic reprogramming in diabetic nephropathy by using mass spectrometry imaging	52
Tailored core‒shell dual metal–organic frameworks as a versatile nanomotor for effective synergistic antitumor therapy	52
Tumor microenvironments self-activated nanoscale metal-organic frameworks for ferroptosis based cancer chemodynamic/photothermal/chemo therapy	52
Remote loading paclitaxel–doxorubicin prodrug into liposomes for cancer combination therapy	52
Selective phytochemicals targeting pancreatic stellate cells as new anti-fibrotic agents for chronic pancreatitis and pancreatic cancer	52
Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing	51
mRNA cancer vaccines: Advances, trends and challenges	51
TIMP1 preserves the blood–brain barrier through interacting with CD63/integrin 1 complex and regulating downstream FAK/RhoA signaling	51
The phytochemical, biological, and medicinal attributes of phytoecdysteroids: An updated review	50
Synthesis, in vitro and in vivo biological evaluation of novel lappaconitine derivatives as potential anti-inflammatory agents	49
A novel cyclic peptide targeting LAG-3 for cancer immunotherapy by activating antigen-specific CD8+ T cell responses	49
Recent advances in microneedles-mediated transdermal delivery of protein and peptide drugs	49
Artemisinin and artemisinin derivatives as anti-fibrotic therapeutics	49
Design, synthesis, and biological evaluation of quinazolin-4(3H)-one derivatives co-targeting poly(ADP-ribose) polymerase-1 and bromodomain containing protein 4 for breast cancer therapy	48
A nanocleaner specifically penetrates the blood‒brain barrier at lesions to clean toxic proteins and regulate inflammation in Alzheimer's disease	47
Impact of particle size and pH on protein corona formation of solid lipid nanoparticles: A proof-of-concept study	47
Discovery of the first potent proteolysis targeting chimera (PROTAC) degrader of indoleamine 2,3-dioxygenase 1	47
Natural products, PGC-1 , and Duchenne muscular dystrophy	47
Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment	47
Validation and invalidation of SARS-CoV-2 main protease inhibitors using the Flip-GFP and Protease-Glo luciferase assays	47
Nucleic acid nanoassembly-enhanced RNA therapeutics and diagnosis	47
Discovery of an orally active VHL-recruiting PROTAC that achieves robust HMGCR degradation and potent hypolipidemic activity in vivo	47
Recent advances in developing small-molecule inhibitors against SARS-CoV-2	46
Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls	46
In situ metabolomics in nephrotoxicity of aristolochic acids based on air flow-assisted desorption electrospray ionization mass spectrometry imaging	46
Self-propelled nanomotor reconstructs tumor microenvironment through synergistic hypoxia alleviation and glycolysis inhibition for promoted anti-metastasis	46
Layered dissolving microneedles as a need-based delivery system to simultaneously alleviate skin and joint lesions in psoriatic arthritis	45
Anticancer drug discovery by targeting cullin neddylation	44
Diversity of the reaction mechanisms of SAM-dependent enzymes	44
MiR-142-3p enhances chemosensitivity of breast cancer cells and inhibits autophagy by targeting HMGB1	44
Notoginsenoside Ft1 acts as a TGR5 agonist but FXR antagonist to alleviate high fat diet-induced obesity and insulin resistance in mice	44
CAR-T cells: Early successes in blood cancer and challenges in solid tumors	43

Smart drug delivery systems for precise cancer therapy	43
Natural compounds modulate the autophagy with potential implication of stroke	43
A smart MnO2-doped graphene oxide nanosheet for enhanced chemo-photodynamic combinatorial therapy via simultaneous oxygenation and glutathione depletion	43
Nature-derived compounds modulating Wnt/ -catenin pathway: a preventive and therapeutic opportunity in neoplastic diseases	43
Discovery of thiosemicarbazone derivatives as effective New Delhi metallo-β-lactamase-1 (NDM-1) inhibitors against NDM-1 producing clinical isolates	43
Lactoferrin-mediated macrophage targeting delivery and patchouli alcohol-based therapeutic strategy for inflammatory bowel diseases	43
Bile acid coordinates microbiota homeostasis and systemic immunometabolism in cardiometabolic diseases	43
Effect of physicochemical properties on in vivo fate of nanoparticle-based cancer immunotherapies	42
Cancer stem cell-targeted chimeric antigen receptor (CAR)-T cell therapy: Challenges and prospects	42
Therapeutic regulation of autophagy in hepatic metabolism	42
Manipulation of immune‒vascular crosstalk: new strategies towards cancer treatment	41
Identification of ferroptosis as a novel mechanism for antitumor activity of natural product derivative a2 in gastric cancer	41
Comparative study of mucoadhesive and mucus-penetrative nanoparticles based on phospholipid complex to overcome the mucus barrier for inhaled delivery of baicalein	41
Dose selection of chloroquine phosphate for treatment of COVID-19 based on a physiologically based pharmacokinetic model	40
Non-apoptotic cell death-based cancer therapy: Molecular mechanism, pharmacological modulators, and nanomedicine	39
Exploring the hydrophobic channel of NNIBP leads to the discovery of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives as potent HIV-1 NNRTIs	39
The disruption of protein−protein interactions with co-chaperones and client substrates as a strategy towards Hsp90 inhibition	39
Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy	39
Mitochondria targeting drugs for neurodegenerative diseases—Design, mechanism and application	39
Recent advances in screening active components from natural products based on bioaffinity techniques	39
Intracellular codelivery of anti-inflammatory drug and anti-miR 155 to treat inflammatory disease	39
Magnetic systems for cancer immunotherapy	39
Functional metabolomics reveal the role of AHR/GPR35 mediated kynurenic acid gradient sensing in chemotherapy-induced intestinal damage	39
Self-assembled FeS-based cascade bioreactor with enhanced tumor penetration and synergistic treatments to trigger robust cancer immunotherapy	38
Dual-responsive nanoparticles with transformable shape and reversible charge for amplified chemo-photodynamic therapy of breast cancer	38
Homo-PROTAC mediated suicide of MDM2 to treat non-small cell lung cancer	38
Evodiamine-inspired dual inhibitors of histone deacetylase 1 (HDAC1) and topoisomerase 2 (TOP2) with potent antitumor activity	38
Can remdesivir and its parent nucleoside GS-441524 be potential oral drugs? An in vitro and in vivo DMPK assessment	38
Peptide–drug conjugates (PDCs): a novel trend of research and development on targeted therapy, hype or hope?	38
Scutellarin inhibits caspase-11 activation and pyroptosis in macrophages via regulating PKA signaling	38
The regulatory and modulatory roles of TRP family channels in malignant tumors and relevant therapeutic strategies	38
Inhibitory effects of baicalein against herpes simplex virus type 1	38
Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase	37
Deficiency of anti-inflammatory cytokine IL-4 leads to neural hyperexcitability and aggravates cerebral ischemia–reperfusion injury	37
Mitochondrial complex I as a therapeutic target for Alzheimer's disease	37
Escape from abluminal LRP1-mediated clearance for boosted nanoparticle brain delivery and brain metastasis treatment	37
Benzydamine inhibits osteoclast differentiation and bone resorption via down-regulation of interleukin-1 expression	36
Discovery of [1,2,3]triazolo[4,5-d]pyrimidine derivatives as highly potent, selective, and cellularly active USP28 inhibitors	36
Activated PKB/GSK-3β synergizes with PKC-δ signaling in attenuating myocardial ischemia/reperfusion injury via potentiation of NRF2 activity: Therapeutic efficacy of dihydrotanshinone-I	36
Enhanced uptake and anti-maturation effect of celastrol-loaded mannosylated liposomes on dendritic cells for psoriasis treatment	36
Abrogation of HnRNP L enhances anti-PD-1 therapy efficacy via diminishing PD-L1 and promoting CD8+ T cell-mediated ferroptosis in castration-resistant prostate cancer	36
In vitro and in vivo correlation for lipid-based formulations: Current status and future perspectives	36
Icariside Ⅱ, a main compound in Epimedii Folium, induces idiosyncratic hepatotoxicity by enhancing NLRP3 inflammasome activation	36
Recent advances in bacteriophage-based therapeutics: Insight into the post-antibiotic era	36
Photothermal/matrix metalloproteinase-2 dual-responsive gelatin nanoparticles for breast cancer treatment	35
Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy	35
Transdermal delivery of Chinese herbal medicine extract using dissolvable microneedles for hypertrophic scar treatment	35
Injectable thermo-responsive nano-hydrogel loading triptolide for the anti-breast cancer enhancement via localized treatment based on “two strikes” effects	35
Role of CD8+ T lymphocyte cells: Interplay with stromal cells in tumor microenvironment	35
Intelligent lesion blood–brain barrier targeting nano-missiles for Alzheimer's disease treatment by anti-neuroinflammation and neuroprotection	35
Targeted inhibition of GRK2 kinase domain by CP-25 to reverse fibroblast-like synoviocytes dysfunction and improve collagen-induced arthritis in rats	35
Novel compound FLZ alleviates rotenone-induced PD mouse model by suppressing TLR4/MyD88/NF-κB pathway through microbiota–gut–brain axis	34
Mechanisms of immune checkpoint inhibitor-mediated liver injury	34
Enterovirus A71 antivirals: Past, present, and future	34
Gold nanoparticle-directed autophagy intervention for antitumor immunotherapy via inhibiting tumor-associated macrophage M2 polarization	34
New guaiane-type sesquiterpenoid dimers from Artemisia atrovirens and their antihepatoma activity	34
Nano-bio interfaces effect of two-dimensional nanomaterials and their applications in cancer immunotherapy	34
Tubeimoside-1 induces TFEB-dependent lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting mTOR	34
Application of immune checkpoint targets in the anti-tumor novel drugs and traditional Chinese medicine development	34
Milk-derived exosomes exhibit versatile effects for improved oral drug delivery	34
Organic carbon monoxide prodrug, BW-CO-111, in protection against chemically-induced gastric mucosal damage	34
The Ca2+-activated chloride channel ANO1/TMEM16A: An emerging therapeutic target for epithelium-originated diseases?	34
Microneedle-based devices for point-of-care infectious disease diagnostics	34
Extracellular vesicles: Emerging tools as therapeutic agent carriers	33
A BRD4 PROTAC nanodrug for glioma therapy via the intervention of tumor cells proliferation, apoptosis and M2 macrophages polarization	33
Conditional reprogramming: next generation cell culture	33
Nature's marvels endowed in gaseous molecules I: Carbon monoxide and its physiological and therapeutic roles	33
Tumor-derived exosomes: Nanovesicles made by cancer cells to promote cancer metastasis	33
Co-delivery of photosensitizer and diclofenac through sequentially responsive bilirubin nanocarriers for combating hypoxic tumors	33
A homogenous nanoporous pulmonary drug delivery system based on metal-organic frameworks with fine aerosolization performance and good compatibility	32
Applying artificial intelligence for cancer immunotherapy	32
Mechanistic insights of the controlled release capacity of polar functional group in transdermal drug delivery system: the relationship of hydrogen bonding strength and controlled release capacity	32
Inhibition of the CDK9–cyclin T1 protein–protein interaction as a new approach against triple-negative breast cancer	32
Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors	31
Bispecific prodrug nanoparticles circumventing multiple immune resistance mechanisms for promoting cancer immunotherapy	31
First small-molecule PROTACs for G protein-coupled receptors: inducing 1A-adrenergic receptor degradation	31
Genome mining combined metabolic shunting and OSMAC strategy of an endophytic fungus leads to the production of diverse natural products	31
Prediction of lipid nanoparticles for mRNA vaccines by the machine learning algorithm	31
Integrative lipidomic and transcriptomic study unravels the therapeutic effects of saikosaponins A and D on non-alcoholic fatty liver disease	31
Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migration of pancreatic cancer cells	31
Bile acid homeostasis in female mice deficient in Cyp7a1 and Cyp27a1	31
Can nanoparticles and nano‒protein interactions bring a bright future for insulin delivery?	31
Gli1 promotes epithelial–mesenchymal transition and metastasis of non-small cell lung carcinoma by regulating snail transcriptional activity and stability	31
Hypoxia-degradable and long-circulating zwitterionic phosphorylcholine-based nanogel for enhanced tumor drug delivery	31
Targeting PFKL with penfluridol inhibits glycolysis and suppresses esophageal cancer tumorigenesis in an AMPK/FOXO3a/BIM-dependent manner	30
Natural products remodel cancer-associated fibroblasts in desmoplastic tumors	30
Precise delivery of obeticholic acid via nanoapproach for triggering natural killer T cell-mediated liver cancer immunotherapy	30
Celastrol targets adenylyl cyclase-associated protein 1 to reduce macrophages-mediated inflammation and ameliorates high fat diet-induced metabolic syndrome in mice	30
Tailoring combinatorial lipid nanoparticles for intracellular delivery of nucleic acids, proteins, and drugs	30
Inhibiting collagen I production and tumor cell colonization in the lung via miR-29a-3p loading of exosome-/liposome-based nanovesicles	30
Phospholipid membrane-decorated deep-penetrated nanocatalase relieve tumor hypoxia to enhance chemo-photodynamic therapy	30
pH-sensitive and bubble-generating mesoporous silica-based nanoparticles for enhanced tumor combination therapy	30
Trends in the biological functions and medical applications of extracellular vesicles and analogues	30
Energy metabolism disorders and potential therapeutic drugs in heart failure	30
Approved HIV reverse transcriptase inhibitors in the past decade	30