Acta Pharmaceutica Sinica B

Article	Citations
Why 90% of clinical drug development fails and how to improve it?	555
Gasdermin D in pyroptosis	325
Long non-coding RNAs: From disease code to drug role	289
The biology, function, and applications of exosomes in cancer	267
Metal-organic frameworks for advanced drug delivery	257
Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies	242
Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma	240
Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways	231
Crystal structure of SARS-CoV-2 papain-like protease	222
The role of tumor-associated macrophages (TAMs) in tumor progression and relevant advance in targeted therapy	216
New opportunities and challenges of natural products research: When target identification meets single-cell multiomics	182
Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway	180
Evolution of blood–brain barrier in brain diseases and related systemic nanoscale brain-targeting drug delivery strategies	170
Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis	158
Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management	158
Ginsenosides in Panax genus and their biosynthesis	152
Antibody–drug conjugates: Recent advances in linker chemistry	151
Alterations of DNA damage response pathway: Biomarker and therapeutic strategy for cancer immunotherapy	149
Traditional Chinese medicine in COVID-19	149
Recent advances in drug delivery systems for targeting cancer stem cells	148
Current approaches of nanomedicines in the market and various stage of clinical translation	146
Oral delivery of proteins and peptides: Challenges, status quo and future perspectives	146
Pharmaceutical cocrystals: A review of preparations, physicochemical properties and applications	145
Pulmonary delivery of siRNA against acute lung injury/acute respiratory distress syndrome	140
Advances and challenges in the treatment of esophageal cancer	136

Small interfering RNA for cancer treatment: overcoming hurdles in delivery	135
Natural exosome-like nanovesicles from edible tea flowers suppress metastatic breast cancer via ROS generation and microbiota modulation	133
Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles and nanoemulsions: A current overview of in vivo studies	132
Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses	131
Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1	130
The cGAS–STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy	126
Influencing factors and strategies of enhancing nanoparticles into tumors in vivo	125
Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1	123
Identifying potential anti-COVID-19 pharmacological components of traditional Chinese medicine Lianhuaqingwen capsule based on human exposure and ACE2 biochromatography screening	122
The progress and perspective of nanoparticle-enabled tumor metastasis treatment	121
Synergetic delivery of triptolide and Ce6 with light-activatable liposomes for efficient hepatocellular carcinoma therapy	118
Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5	118
Emerging role of natural products in cancer immunotherapy	118
Exploration and insights into the cellular internalization and intracellular fate of amphiphilic polymeric nanocarriers	117
In vivo delivery of CRISPR-Cas9 therapeutics: Progress and challenges	117
Recent development on COX-2 inhibitors as promising anti-inflammatory agents: The past 10 years	116
The influence of the gut microbiota on the bioavailability of oral drugs	116
Recent advances in drug delivery applications of cubosomes, hexosomes, and solid lipid nanoparticles	115
Biological drug and drug delivery-mediated immunotherapy	114
Targeted nanomedicines remodeling immunosuppressive tumor microenvironment for enhanced cancer immunotherapy	107
An update on oral drug delivery via intestinal lymphatic transport	106
Pure drug nano-assemblies: A facile carrier-free nanoplatform for efficient cancer therapy	106
Cell membrane coated-nanoparticles for cancer immunotherapy	102
Integrins as attractive targets for cancer therapeutics	101
Angiotensin-converting enzyme 2 (ACE2): SARS-CoV-2 receptor and RAS modulator	101
Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation	100
Carbohydrate-based drugs launched during 2000−2021	98
Recent developments on PET radiotracers for TSPO and their applications in neuroimaging	94
Nanomedicine for acute respiratory distress syndrome: The latest application, targeting strategy, and rational design	93
GSH-sensitive polymeric prodrug: Synthesis and loading with photosensitizers as nanoscale chemo-photodynamic anti-cancer nanomedicine	92
Recent progress in sono-photodynamic cancer therapy: From developed new sensitizers to nanotechnology-based efficacy-enhancing strategies	90
Recent advances in nanomedicines for the treatment of ischemic stroke	89
Cell membrane-derived vesicles for delivery of therapeutic agents	88
Impairment of the autophagy–lysosomal pathway in Alzheimer's diseases: Pathogenic mechanisms and therapeutic potential	87
Symphony of nanomaterials and immunotherapy based on the cancer–immunity cycle	87
A cyclodextrin-based nanoformulation achieves co-delivery of ginsenoside Rg3 and quercetin for chemo-immunotherapy in colorectal cancer	87
Bioresponsive immune-booster-based prodrug nanogel for cancer immunotherapy	87
Ginsenoside Rg1 ameliorates blood–brain barrier disruption and traumatic brain injury via attenuating macrophages derived exosomes miR-21 release	85
Nanomedicine-based drug delivery towards tumor biological and immunological microenvironment	85
The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatment	83
Target-based anticancer indole derivatives and insight into structure‒activity relationship: A mechanistic review update (2018–2021)	81
Pathophysiology of obesity and its associated diseases	80
Pharmaceutical strategies to extend pulmonary exposure of inhaled medicines	80
Selective inhibition of CDK4/6: A safe and effective strategy for developing anticancer drugs	78
A comprehensive review of integrative pharmacology-based investigation: A paradigm shift in traditional Chinese medicine	78
Nanomedicines for the treatment of rheumatoid arthritis: State of art and potential therapeutic strategies	77
Recent developments in the medicinal chemistry of single boron atom-containing compounds	76
Insight into chemical basis of traditional Chinese medicine based on the state-of-the-art techniques of liquid chromatography−mass spectrometry	76
Membrane-disruptive peptides/peptidomimetics-based therapeutics: Promising systems to combat bacteria and cancer in the drug-resistant era	74
A review of existing strategies for designing long-acting parenteral formulations: Focus on underlying mechanisms, and future perspectives	74

Development of small-molecule tropomyosin receptor kinase (TRK) inhibitors for NTRK fusion cancers	74
Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway	73
Smart drug delivery systems for precise cancer therapy	72
A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis	72
Opportunities and challenges of three-dimensional printing technology in pharmaceutical formulation development	71
Natural products as LSD1 inhibitors for cancer therapy	71
Peptide–drug conjugates (PDCs): a novel trend of research and development on targeted therapy, hype or hope?	71
Nanomedicines modulating tumor immunosuppressive cells to enhance cancer immunotherapy	71
Receptor-mediated targeted drug delivery systems for treatment of inflammatory bowel disease: Opportunities and emerging strategies	70
Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies	70
Cathepsin B-responsive and gadolinium-labeled branched glycopolymer-PTX conjugate-derived nanotheranostics for cancer treatment	69
Spatial-resolved metabolomics reveals tissue-specific metabolic reprogramming in diabetic nephropathy by using mass spectrometry imaging	68
Nucleic acid nanoassembly-enhanced RNA therapeutics and diagnosis	67
Tumor microenvironments self-activated nanoscale metal-organic frameworks for ferroptosis based cancer chemodynamic/photothermal/chemo therapy	67
Bile acid coordinates microbiota homeostasis and systemic immunometabolism in cardiometabolic diseases	66
SUV39H1 deficiency suppresses clear cell renal cell carcinoma growth by inducing ferroptosis	65
Targeting autophagy using small-molecule compounds to improve potential therapy of Parkinson's disease	65
Notoginsenoside Ft1 acts as a TGR5 agonist but FXR antagonist to alleviate high fat diet-induced obesity and insulin resistance in mice	65
Delivery strategies of amphotericin B for invasive fungal infections	65
SIRT6 as a key event linking P53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation	65
Emerging vaccine nanotechnology: From defense against infection to sniping cancer	65
Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing	65
Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators	63
mRNA cancer vaccines: Advances, trends and challenges	63
Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology: Implications for Alzheimer's disease therapy	63
GSH-responsive SN38 dimer-loaded shape-transformable nanoparticles with iRGD for enhancing chemo-photodynamic therapy	62
Benzimidazole and its derivatives as cancer therapeutics: The potential role from traditional to precision medicine	62
Artemisinin and artemisinin derivatives as anti-fibrotic therapeutics	61
Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls	61
Natural compounds modulate the autophagy with potential implication of stroke	61
The chromosome-level reference genome assembly for Dendrobium officinale and its utility of functional genomics research and molecular breeding study	61
Impact of particle size and pH on protein corona formation of solid lipid nanoparticles: A proof-of-concept study	60
Milk-derived exosomes exhibit versatile effects for improved oral drug delivery	60
Recent advances in microneedles-mediated transdermal delivery of protein and peptide drugs	60
The phytochemical, biological, and medicinal attributes of phytoecdysteroids: An updated review	59
Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment	57
Self-propelled nanomotor reconstructs tumor microenvironment through synergistic hypoxia alleviation and glycolysis inhibition for promoted anti-metastasis	56
Validation and invalidation of SARS-CoV-2 main protease inhibitors using the Flip-GFP and Protease-Glo luciferase assays	56
Tailored core‒shell dual metal–organic frameworks as a versatile nanomotor for effective synergistic antitumor therapy	56
Layered dissolving microneedles as a need-based delivery system to simultaneously alleviate skin and joint lesions in psoriatic arthritis	55
Diversity of the reaction mechanisms of SAM-dependent enzymes	55
Prediction of lipid nanoparticles for mRNA vaccines by the machine learning algorithm	55
Gli1 promotes epithelial–mesenchymal transition and metastasis of non-small cell lung carcinoma by regulating snail transcriptional activity and stability	54
Identification of ferroptosis as a novel mechanism for antitumor activity of natural product derivative a2 in gastric cancer	54
Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy	54
The regulatory and modulatory roles of TRP family channels in malignant tumors and relevant therapeutic strategies	54
Recent advances in bacteriophage-based therapeutics: Insight into the post-antibiotic era	53
Approved HIV reverse transcriptase inhibitors in the past decade	53
A smart MnO2-doped graphene oxide nanosheet for enhanced chemo-photodynamic combinatorial therapy via simultaneous oxygenation and glutathione depletion	53
Recent advances in developing small-molecule inhibitors against SARS-CoV-2	53
Non-apoptotic cell death-based cancer therapy: Molecular mechanism, pharmacological modulators, and nanomedicine	53
Discovery of an orally active VHL-recruiting PROTAC that achieves robust HMGCR degradation and potent hypolipidemic activity in vivo	53
CAR-T cells: Early successes in blood cancer and challenges in solid tumors	52
A nanocleaner specifically penetrates the blood‒brain barrier at lesions to clean toxic proteins and regulate inflammation in Alzheimer's disease	52
Mitochondrial complex I as a therapeutic target for Alzheimer's disease	52
Abrogation of HnRNP L enhances anti-PD-1 therapy efficacy via diminishing PD-L1 and promoting CD8+ T cell-mediated ferroptosis in castration-resistant prostate cancer	51
Homo-PROTAC mediated suicide of MDM2 to treat non-small cell lung cancer	51
Therapeutic regulation of autophagy in hepatic metabolism	51
Enterovirus A71 antivirals: Past, present, and future	51
Design, synthesis, and biological evaluation of quinazolin-4(3H)-one derivatives co-targeting poly(ADP-ribose) polymerase-1 and bromodomain containing protein 4 for breast cancer therapy	51
Effect of physicochemical properties on in vivo fate of nanoparticle-based cancer immunotherapies	51
Role of CD8+ T lymphocyte cells: Interplay with stromal cells in tumor microenvironment	51
Transdermal delivery of Chinese herbal medicine extract using dissolvable microneedles for hypertrophic scar treatment	50
Novel compound FLZ alleviates rotenone-induced PD mouse model by suppressing TLR4/MyD88/NF-κB pathway through microbiota–gut–brain axis	50
Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota	50
A BRD4 PROTAC nanodrug for glioma therapy via the intervention of tumor cells proliferation, apoptosis and M2 macrophages polarization	49
The disruption of protein−protein interactions with co-chaperones and client substrates as a strategy towards Hsp90 inhibition	49
Manipulation of immune‒vascular crosstalk: new strategies towards cancer treatment	49
Functional metabolomics reveal the role of AHR/GPR35 mediated kynurenic acid gradient sensing in chemotherapy-induced intestinal damage	49
Self-assembled FeS-based cascade bioreactor with enhanced tumor penetration and synergistic treatments to trigger robust cancer immunotherapy	49
Dual-responsive nanoparticles with transformable shape and reversible charge for amplified chemo-photodynamic therapy of breast cancer	49
Inhibiting DNA methylation alleviates cisplatin-induced hearing loss by decreasing oxidative stress-induced mitochondria-dependent apoptosis via the LRP1–PI3K/AKT pathway	48
Gentiopicroside targets PAQR3 to activate the PI3K/AKT signaling pathway and ameliorate disordered glucose and lipid metabolism	48
Cancer stem cell-targeted chimeric antigen receptor (CAR)-T cell therapy: Challenges and prospects	48
Apolipoprotein E and Alzheimer's disease	47
Bilayer hydrogel dressing with lysozyme-enhanced photothermal therapy for biofilm eradication and accelerated chronic wound repair	47
Antibody–drug conjugates: Recent advances in payloads	47
Mitochondria targeting drugs for neurodegenerative diseases—Design, mechanism and application	46
A novel inhibitor of N6-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities	46
Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease	46

Magnetic systems for cancer immunotherapy	46
Extracellular vesicles: Emerging tools as therapeutic agent carriers	46
Discovery of thiosemicarbazone derivatives as effective New Delhi metallo-β-lactamase-1 (NDM-1) inhibitors against NDM-1 producing clinical isolates	46
Targeting histone deacetylases for cancer therapy: Trends and challenges	46
Escape from abluminal LRP1-mediated clearance for boosted nanoparticle brain delivery and brain metastasis treatment	45
Photothermal/matrix metalloproteinase-2 dual-responsive gelatin nanoparticles for breast cancer treatment	45
The Ca2+-activated chloride channel ANO1/TMEM16A: An emerging therapeutic target for epithelium-originated diseases?	45
New guaiane-type sesquiterpenoid dimers from Artemisia atrovirens and their antihepatoma activity	45
Gold nanoparticle-directed autophagy intervention for antitumor immunotherapy via inhibiting tumor-associated macrophage M2 polarization	45
Enhanced uptake and anti-maturation effect of celastrol-loaded mannosylated liposomes on dendritic cells for psoriasis treatment	44
Recent advances in the translation of drug metabolism and pharmacokinetics science for drug discovery and development	44
The generation of PD-L1 and PD-L2 in cancer cells: From nuclear chromatin reorganization to extracellular presentation	44
Autophagy enhanced by curcumin ameliorates inflammation in atherogenesis via the TFEB–P300–BRD4 axis	44
Application of immune checkpoint targets in the anti-tumor novel drugs and traditional Chinese medicine development	44
Targeting PFKL with penfluridol inhibits glycolysis and suppresses esophageal cancer tumorigenesis in an AMPK/FOXO3a/BIM-dependent manner	43
A homogenous nanoporous pulmonary drug delivery system based on metal-organic frameworks with fine aerosolization performance and good compatibility	43
Small molecule-based immunomodulators for cancer therapy	43
Bile acid homeostasis in female mice deficient in Cyp7a1 and Cyp27a1	42
NAMPT-targeting PROTAC promotes antitumor immunity via suppressing myeloid-derived suppressor cell expansion	42
Applying artificial intelligence for cancer immunotherapy	42
Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase	42
Microneedle-based devices for point-of-care infectious disease diagnostics	42
Medical micro- and nanomotors in the body	42
Tumor-derived exosomes: Nanovesicles made by cancer cells to promote cancer metastasis	42
Tubeimoside-1 induces TFEB-dependent lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting mTOR	42
Scutellarin inhibits caspase-11 activation and pyroptosis in macrophages via regulating PKA signaling	42
Injectable thermo-responsive nano-hydrogel loading triptolide for the anti-breast cancer enhancement via localized treatment based on “two strikes” effects	42
Nature's marvels endowed in gaseous molecules I: Carbon monoxide and its physiological and therapeutic roles	41
Emodin attenuates severe acute pancreatitis-associated acute lung injury by suppressing pancreatic exosome-mediated alveolar macrophage activation	41
Intelligent lesion blood–brain barrier targeting nano-missiles for Alzheimer's disease treatment by anti-neuroinflammation and neuroprotection	41
Can remdesivir and its parent nucleoside GS-441524 be potential oral drugs? An in vitro and in vivo DMPK assessment	41
Inhibitory effects of baicalein against herpes simplex virus type 1	41
Tailoring combinatorial lipid nanoparticles for intracellular delivery of nucleic acids, proteins, and drugs	41
Activated PKB/GSK-3β synergizes with PKC-δ signaling in attenuating myocardial ischemia/reperfusion injury via potentiation of NRF2 activity: Therapeutic efficacy of dihydrotanshinone-I	41
Schaftoside inhibits 3CLpro and PLpro of SARS-CoV-2 virus and regulates immune response and inflammation of host cells for the treatment of COVID-19	40
Co-delivery of photosensitizer and diclofenac through sequentially responsive bilirubin nanocarriers for combating hypoxic tumors	40
Inhibition of the CDK9–cyclin T1 protein–protein interaction as a new approach against triple-negative breast cancer	40
Integrative lipidomic and transcriptomic study unravels the therapeutic effects of saikosaponins A and D on non-alcoholic fatty liver disease	40
Salmonella flagella confer anti-tumor immunological effect via activating Flagellin/TLR5 signalling within tumor microenvironment	40
Cascade two-stage tumor re-oxygenation and immune re-sensitization mediated by self-assembled albumin-sorafenib nanoparticles for enhanced photodynamic immunotherapy	40
Nano-bio interfaces effect of two-dimensional nanomaterials and their applications in cancer immunotherapy	40
Mechanisms of immune checkpoint inhibitor-mediated liver injury	40
Fucoidan-functionalized activated platelet-hitchhiking micelles simultaneously track tumor cells and remodel the immunosuppressive microenvironment for efficient metastatic cancer treatment	39
Inhaled curcumin mesoporous polydopamine nanoparticles against radiation pneumonitis	39
Bispecific prodrug nanoparticles circumventing multiple immune resistance mechanisms for promoting cancer immunotherapy	39
Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy	39
The long-circulating effect of pegylated nanoparticles revisited via simultaneous monitoring of both the drug payloads and nanocarriers	39
Targeted inhibition of GRK2 kinase domain by CP-25 to reverse fibroblast-like synoviocytes dysfunction and improve collagen-induced arthritis in rats	39
Precise delivery of obeticholic acid via nanoapproach for triggering natural killer T cell-mediated liver cancer immunotherapy	38
Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics	38
Inhibiting collagen I production and tumor cell colonization in the lung via miR-29a-3p loading of exosome-/liposome-based nanovesicles	38
Engineering a folic acid-decorated ultrasmall gemcitabine nanocarrier for breast cancer therapy: Dual targeting of tumor cells and tumor-associated macrophages	38
Genome mining combined metabolic shunting and OSMAC strategy of an endophytic fungus leads to the production of diverse natural products	38
Multifunctional regulatory protein connective tissue growth factor (CTGF): A potential therapeutic target for diverse diseases	38
In vitro and in vivo correlation for lipid-based formulations: Current status and future perspectives	38
Detailed resume of RNA m6A demethylases	38
Current research trends of nanomedicines	38
A smart dual-drug nanosystem based on co-assembly of plant and food-derived natural products for synergistic HCC immunotherapy	38
Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors	38
Preclinical evaluation and pilot clinical study of [18F]AlF-labeled FAPI-tracer for PET imaging of cancer associated fibroblasts	38
Functional biomaterials for comprehensive periodontitis therapy	38
Hypoxia-degradable and long-circulating zwitterionic phosphorylcholine-based nanogel for enhanced tumor drug delivery	38
NAT10 promotes cell proliferation by acetylating CEP170 mRNA to enhance translation efficiency in multiple myeloma	37
Progress in the studies on the molecular mechanisms associated with multidrug resistance in cancers	36
Celastrol targets adenylyl cyclase-associated protein 1 to reduce macrophages-mediated inflammation and ameliorates high fat diet-induced metabolic syndrome in mice	36
Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migration of pancreatic cancer cells	36
Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy–lysosomal pathway	36
Emerging biotechnology applications in natural product and synthetic pharmaceutical analyses	36
Mucosal vaccine delivery: A focus on the breakthrough of specific barriers	36
Pure photosensitizer-driven nanoassembly with core-matched PEGylation for imaging-guided photodynamic therapy	36
Organic carbon monoxide prodrug, BW-CO-111, in protection against chemically-induced gastric mucosal damage	36
Natural products remodel cancer-associated fibroblasts in desmoplastic tumors	35
Energy metabolism disorders and potential therapeutic drugs in heart failure	35
Tumor-targeted/reduction-triggered composite multifunctional nanoparticles for breast cancer chemo-photothermal combinational therapy	35
Trends in the biological functions and medical applications of extracellular vesicles and analogues	35
Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions	35
The role of caveolin-1 in the biofate and efficacy of anti-tumor drugs and their nano-drug delivery systems	35
Therapeutic strategies of glioblastoma (GBM): The current advances in the molecular targets and bioactive small molecule compounds	35
The contribution of absorption of integral nanocrystals to enhancement of oral bioavailability of quercetin	34
MCDB: A comprehensive curated mitotic catastrophe database for retrieval, protein sequence alignment, and target prediction	34
Recent progress of aptamer‒drug conjugates in cancer therapy	34
Inhibiting autophagy enhances sulforaphane-induced apoptosis via targeting NRF2 in esophageal squamous cell carcinoma	34
Multi-omics approaches identify SF3B3 and SIRT3 as candidate autophagic regulators and druggable targets in invasive breast carcinoma	34
Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's disease	34
Roles of focal adhesion proteins in skeleton and diseases	34
The gut microbial metabolite, 3,4-dihydroxyphenylpropionic acid, alleviates hepatic ischemia/reperfusion injury via mitigation of macrophage pro-inflammatory activity in mice	34
Polymeric nanocarriers for nose-to-brain drug delivery in neurodegenerative diseases and neurodevelopmental disorders	34
Real-time SERS monitoring anticancer drug release along with SERS/MR imaging for pH-sensitive chemo-phototherapy	34
Autophagy and beyond: Unraveling the complexity of UNC-51-like kinase 1 (ULK1) from biological functions to therapeutic implications	34
pH-sensitive and bubble-generating mesoporous silica-based nanoparticles for enhanced tumor combination therapy	33
Neutralization of SARS-CoV-2 pseudovirus using ACE2-engineered extracellular vesicles	33
Preclinical models of idiosyncratic drug-induced liver injury (iDILI): Moving towards prediction	33
TPGS/hyaluronic acid dual-functionalized PLGA nanoparticles delivered through dissolving microneedles for markedly improved chemo-photothermal combined therapy of superficial tumor	33
Can nanoparticles and nano‒protein interactions bring a bright future for insulin delivery?	33
Phosphorylation regulates cullin-based ubiquitination in tumorigenesis	33