Acta Pharmaceutica Sinica B

Article	Citations
Editorial of Special Column “Novel Peptides and Peptidomimetics in Drug Discovery”	987
Drug discovery in China: A snapshot of recent progress	467
Research and development of Chinese anti-COVID-19 drugs	413
Sequential dual-locking strategy using photoactivated Pt(IV)-based metallo-nano prodrug for enhanced chemotherapy and photodynamic efficacy by triggering ferroptosis and macrophage polarization	388
Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis	369
Azvudine reduces the in-hospital mortality of COVID-19 patients: A retrospective cohort study	356
Spatial metabolomics highlights metabolic reprogramming in acute myeloid leukemia mice through creatine pathway	355
Regulation of histidine metabolism by Lactobacillus Reuteri mediates the pathogenesis and treatment of ischemic stroke	296
Novel carbazole attenuates vascular remodeling through STAT3/CIAPIN1 signaling in vascular smooth muscle cells	276
Lycorine hydrochloride directly targets UBA1 to suppress cellular senescence	254
A novel heterologous receptor-binding domain dodecamer universal mRNA vaccine against SARS-CoV-2 variants	236
Polymer-assisted PD-L1 degradation and targeted photodynamic therapy synergize to suppress immunodeficient tumors	229
Rapid discovery of drug-introduced multiple organ dysfunction via NIR-II fluorescent imaging	229
Functional identification of the terpene synthase family involved in diterpenoid alkaloids biosynthesis in Aconitum carmichaelii	229
MCDB: A comprehensive curated mitotic catastrophe database for retrieval, protein sequence alignment, and target prediction	228
Allosterically activating SHP2 by oleanolic acid inhibits STAT3–Th17 axis for ameliorating colitis	227
Reconstitution of biosynthetic pathway for mushroom-derived cyathane diterpenes in yeast and generation of new “non-natural” analogues	223
Discovery and mechanism verification of first-in-class hydrophobic tagging-based degraders of HBV core protein	213
Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer	207
Identification of a JAK–STAT–miR155HG positive feedback loop in regulating natural killer (NK) cells proliferation and effector functions	204
Innovative discovery and mechanistic validation of HyT-PD ligands for selective CDK9-targeted protein degradation	203
[18F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models	191
Unravelling the target landscape of tranylcypromines for new drug discovery	190
Discovery and development of brain-penetrant 18F-labeled radioligands for neuroimaging of the sigma-2 receptors	188
Transformation of peptides to small molecules in medicinal chemistry: Challenges and opportunities	185

Identification of anti-Mycobacterium tuberculosis agents targeting the interaction of bacterial division proteins FtsZ and SepFe	181
Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles	180
The role of SARS-CoV-2 main protease in innate immune regulation: From molecular mechanisms to therapeutic implications	179
PAFR/Stat3 axis maintains the symbiotic ecosystem between tumor and stroma to facilitate tumor malignancy	174
Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions	160
Two types of coumarins-specific enzymes complete the last missing steps in pyran- and furanocoumarins biosynthesis	154
Free energy perturbation (FEP)-guided scaffold hopping	151
Spirohypertones A and B as potent antipsoriatics: Tumor necrosis factor-α inhibitors with unprecedented chemical architectures	149
Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk	144
Decoding the chromatin accessibility in Andrographis paniculata genome, a case study of genome-wide investigation of the cis-regulatory elements in medicinal plants	137
Reductive stress—a common metabolic feature of obesity and cancer	136
Akkermansia muciniphila-derived acetate activates the hepatic AMPK/SIRT1/PGC-1α axis to alleviate ferroptosis in metabolic-associated fatty liver disease	136
Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia	136
Gasdermin D-mediated pyroptosis in myocardial ischemia and reperfusion injury: Cumulative evidence for future cardioprotective strategies	133
Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin: Creation of an unnatural analogue with improved anticancer properties	130
An update on oral drug delivery via intestinal lymphatic transport	127
Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism	127
Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice	126
A novel inhibitor of N6-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities	124
Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy	123
A novel shark VNAR antibody-based immunotoxin targeting TROP-2 for cancer therapy	122
Editor Profile: Guest Editor of Special Column on RNA Therapeutics and Drug Delivery Technologies for Medical Applications	120
Five trends of China's pharmaceutical industry in 2022	118
Cover Story	117
Transferrin receptor-targeted immunostimulant for photodynamic immunotherapy against metastatic tumors through β-catenin/CREB interruption	116
Exemplifying interspecies variation of liposome in vivo fate by the effects of anti-PEG antibodies	115
FOXO3 mutation predicting gefitinib-induced hepatotoxicity in NSCLC patients through regulation of autophagy	111
Design, synthesis, and antitumor activity of novel thioheterocyclic nucleoside derivatives by suppressing the c-MYC pathway	110
Nanoparticle drug delivery system for the treatment of brain tumors: Breaching the blood–brain barrier	109
Nanoparticles (NPs)-mediated lncBCMA silencing to promote eEF1A1 ubiquitination and suppress breast cancer growth and metastasis	108
Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis	105
Melatonin alleviates alcoholic liver disease via EGFR–BRG1–TERT axis regulation	104
Recent advances in developing small-molecule inhibitors against SARS-CoV-2	103
Therapeutic potential of traditional Chinese medicine for the treatment of NAFLD: A promising drug Potentilla discolor Bunge	101
“Weibing” in traditional Chinese medicine—biological basis and mathematical representation of disease-susceptible state	99
Free fatty acid receptor-4 regulates T-cell-mediated allogeneic reaction through activating an aryl hydrocarbon receptor pathway	99
GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer	98
Structure-based drug discovery of novel fused-pyrazolone carboxamide derivatives as potent and selective AXL inhibitors	98
Submicron-sized superantigen biomimetic liposomes: enhanced lung accumulation and synergistic chemoimmunotherapy	98
Suppressing Wnt signaling of the blood‒tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases	98
A preclinical and first-in-human study of superstable homogeneous radiolipiodol for revolutionizing interventional diagnosis and treatment of hepatocellular carcinoma	95
Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation	93
Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy	93
Improved prebiotic-based “shield” equipped probiotics for enhanced colon cancer therapy by polarizing M1 macrophages and regulating intestinal microbiota	91
Development of Chinese herbal medicine for sensorineural hearing loss	90
Insights into therapeutic peptides in the cancer-immunity cycle: Update and challenges	89
Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein (RNP) to inhibit herpes simplex virus1 infection in vitro and in vivo	87
The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation	87
Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells	87
Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease	86

Commentary: The central lymphatic drainage in pharmacological, surgical and physical therapies of Alzheimer's disease	86
Unlocking T cell exhaustion: Insights and implications for CAR-T cell therapy	85
Nucleic acid-based delivery system delivering platinum drugs cooperates with siRNA for potentiated chemo-immunotherapy by reducing phosphatidylserine exposure and activating the cGAS–STING pathway	84
Engineered nanoparticles for precise targeted drug delivery and enhanced therapeutic efficacy in cancer immunotherapy	83
The role of bacteria and its derived biomaterials in cancer radiotherapy	83
High-efficient discovering the potent anti-Notum agents from herbal medicines for combating glucocorticoid-induced osteoporosis	83
NIR-II-activated whole-cell vaccine with ultra-efficient semiconducting diradical oligomers for breast carcinoma growth and metastasis inhibition	83
Bimetallic nanoparticles as cascade sensitizing amplifiers for low-dose and robust cancer radio-immunotherapy	82
Astaxanthine attenuates cisplatin ototoxicity in vitro and protects against cisplatin-induced hearing loss in vivo	82
Immune cell membrane-based biomimetic nanomedicine for treating cancer metastasis	82
Remembering your A, B, C's: Alzheimer's disease and ABCA1	82
Targeting the Warburg effect: A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer	82
Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in non-alcoholic steatohepatitis patients	81
Dihydromyricetin mitigates abdominal aortic aneurysm via transcriptional and post-transcriptional regulation of heme oxygenase-1 in vascular smooth muscle cells	80
Adipose ADM2 ameliorates NAFLD via promotion of ceramide catabolism	80
Table of Contents	79
Advances in development of antiviral strategies against respiratory syncytial virus	78
Viral miRNA-mediated activation of hyaluronan production as a drug target against COVID-19	76
ROS-degradable polythioketal urethane scaffold for porcine wound repair	76
Unveiling nonribosomal peptide synthetases from the ergot fungus Claviceps purpurea involved in the formation of diverse ergopeptines	76
The role of botanical triterpenoids and steroids in bile acid metabolism, transport, and signaling: Pharmacological and toxicological implications	75
Charge-guided masking of a membrane-destabilizing peptide enables efficient endosomal escape for targeted intracellular delivery of proteins	75
KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer	75
JAK inhibition ameliorated experimental autoimmune encephalomyelitis by blocking GM-CSF-driven inflammatory signature of monocytes	74
Cholinergic dysfunction-induced insufficient activation of alpha7 nicotinic acetylcholine receptor drives the development of rheumatoid arthritis through promoting protein citrullination via the SP3/P	74
Recent advances to address challenges in extracellular vesicle-based applications for lung cancer	74
The chromosome-scale assembly of the Notopterygium incisum genome provides insight into the structural diversity of coumarins	73
Intravenous delivery of STING agonists using acid-sensitive polycationic polymer-modified lipid nanoparticles for enhanced tumor immunotherapy	73
Unveiling ferroptosis as a promising therapeutic avenue for colorectal cancer and colitis treatment	73
A neutrophil-biomimic platform for eradicating metastatic breast cancer stem-like cells by redox microenvironment modulation and hypoxia-triggered differentiation therapy	72
Synergistic metabolic modulation of fibroblast-like synoviocytes via targeted dual prodrug nanoparticles to mitigate rheumatoid arthritis	72
Astrocyte FGF7/FGFR2 autocrine signaling mediates neuroinflammation and promotes MPTP-induced degeneration of dopaminergic neurons	71
Inhibiting collagen I production and tumor cell colonization in the lung via miR-29a-3p loading of exosome-/liposome-based nanovesicles	71
Actively separated microneedle patch for sustained-release of growth hormone to treat growth hormone deficiency	70
Topical adhesive spatio-temporal nanosystem co-delivering chlorin e6 and HMGB1 inhibitor glycyrrhizic acid for in situ psoriasis chemo-phototherapy	70
Optical substrates for drug-metabolizing enzymes: Recent advances and future perspectives	70
Antrodia cinnamomea exerts an anti-hepatoma effect by targeting PI3K/AKT-mediated cell cycle progression in vitro and in vivo	69
Safety, dosimetry, and efficacy of an optimized long-acting somatostatin analog for peptide receptor radionuclide therapy in metastatic neuroendocrine tumors: From preclinical testing to first-in-huma	69
Biomimetic nanomedicines for precise atherosclerosis theranostics	68
PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism	68
Nanoparticles with rough surface improve the therapeutic effect of photothermal immunotherapy against melanoma	68
Recent advances in the bench-to-bedside translation of cancer nanomedicines	67
Metal nanoparticles for cancer therapy: Precision targeting of DNA damage	67
Cell membrane-derived vesicles for delivery of therapeutic agents	67
Pharmacological modulation of autophagy for Alzheimer's disease therapy: Opportunities and obstacles	66
Colon-specific controlled release of oral liposomes for enhanced chemo-immunotherapy against colorectal cancer	66
Logic-gated tumor-microenvironment nanoamplifier enables targeted delivery of CRISPR/Cas9 for multimodal cancer therapy	66
Hyperglycemia activates FGFR1 via TLR4/c-Src pathway to induce inflammatory cardiomyopathy in diabetes	66
Mitochondrial transplantation as a promising therapy for mitochondrial diseases	65
Table of Contents	64
Regulating the microenvironment with nanomaterials: Potential strategies to ameliorate COVID-19	63
Antitumor activity and low gastrointestinal toxicity of a novel selective inhibitor of nuclear export, SZJK-0421, in multiple myeloma	63
Discovery of a novel thiophene carboxamide analogue as a highly potent and selective sphingomyelin synthase 2 inhibitor for dry eye disease therapy	62
Ruscogenin alleviates LPS-triggered pulmonary endothelial barrier dysfunction through targeting NMMHC IIA to modulate TLR4 signaling	62
Erratum to “Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis” [Acta Pharm Sin B 14 (2024) 3493–3512]	62
Selectively T cell phosphorylation activation of azvudine in the thymus tissue with immune protection effect	62
A chromosome-level Dendrobium moniliforme genome assembly reveals the regulatory mechanisms of flavonoid and carotenoid biosynthesis pathways	61
Editor Profiles: Guest Editors of Special Column on Nanomedicines for Tumor Microenvironment Modulation	61
Extracellular vesicles from human urine-derived stem cells delay aging through the transfer of PLAU and TIMP1	61
Transient induction of actin cytoskeletal remodeling associated with dedifferentiation, proliferation, and redifferentiation stimulates cardiac regeneration	61
DNA-PK inhibition by M3814 enhances chemosensitivity in non-small cell lung cancer	60
Psychological stress-activated NR3C1/NUPR1 axis promotes ovarian tumor metastasis	60
Bioorthogonal microglia-inspired mesenchymal stem cell bioengineering system creates livable niches for enhancing ischemic stroke recovery via the hormesis	60
Immune organoid for cancer immunotherapy	59
Cover Story	59
DNA origami nanodevice with spatial regulation of CD95 signaling for rheumatoid arthritis treatment	59
PKCα inhibitors promote breast cancer immune evasion by maintaining PD-L1 stability	58
Bladder microenvironment actuated proteomotors with ammonia amplification for enhanced cancer treatment	58
Oral garlic-derived nanoparticles improve cancer immunotherapy	58
Dual-responsive nanoparticles with transformable shape and reversible charge for amplified chemo-photodynamic therapy of breast cancer	58
Pancreatic melatonin enhances anti-tumor immunity in pancreatic adenocarcinoma through regulating tumor-associated neutrophils infiltration and NETosis	57
Microglial APOE4 promotes neuron degeneration in Alzheimer's disease through inhibition of lipid droplet autophagy	56
Deubiquitination complex platform: A plausible mechanism for regulating the substrate specificity of deubiquitinating enzymes	56
TPGS/hyaluronic acid dual-functionalized PLGA nanoparticles delivered through dissolving microneedles for markedly improved chemo-photothermal combined therapy of superficial tumor	56
FGF4 protects the liver from immune-mediated injury by activating CaMKKβ-PINK1 signal pathway to inhibit hepatocellular apoptosis	56
Emerging delivery systems based on aqueous two-phase systems: A review	55
Spatiotemporally delivery of Cas9 ribonucleoprotein/DNAzyme logic systems using near-infrared upconversion nanomachine for precise immunotherapy	55
Precise assembly of inside-out cell membrane camouflaged nanoparticles via bioorthogonal reactions for improving drug leads capturing	54
A hybrid bacterium with tumor-associated macrophage polarization for enhanced photothermal-immunotherapy	54
Engineering nanomedicines for immunogenic eradication of cancer cells: Recent trends and synergistic approaches	54

Comparative genomic analysis of esophageal squamous cell carcinoma and adenocarcinoma: New opportunities towards molecularly targeted therapy	54
Amelioration of ethanol-induced oxidative stress and alcoholic liver disease by in vivo RNAi targeting Cyp2e1	53
Emerging trends in organ-on-a-chip systems for drug screening	53
Cell-derived nanovesicles from mesenchymal stem cells as extracellular vesicle-mimetics in wound healing	53
Pharmaceutical strategies to extend pulmonary exposure of inhaled medicines	53
Structure-based design and optimization lead to the identification of novel dihydrothiopyrano[3,2-d]pyrimidine derivatives as potent HIV-1 inhibitors against drug-resistant variants	53
MicroRNA-34c-5p provokes isoprenaline-induced cardiac hypertrophy by modulating autophagy via targeting ATG4B	53
Cover Story	52
Table of Contents	52
Editorial of Special Issue of Hot Topic Reviews in Drug Delivery	52
Dual-responsive supramolecular photodynamic nanomedicine with activatable immunomodulation for enhanced antitumor therapy	52
Table of Contents	52
Nature-inspired supramolecular assemblies for precise biomedical imaging and therapy	51
Cover Story	51
WITHDRAWN: A neurovascular dual-targeting platelet-like bioinspired nanoplatform for ischemic stroke treatment	51
Identification of human LDHC4 as a potential target for anticancer drug discovery	50
Author correction to ‘Bioengineered miR-124-3p prodrug selectively alters the proteome of human carcinoma cells to control multiple cellular components and lung metastasis in vivo’ [Acta Pharmaceutica	50
Author correction to ‘Ruscogenin alleviates LPS-triggered pulmonary endothelial barrier dysfunction through targeting NMMHC IIA to modulate TLR4 signaling’ [Acta Pharmaceutica Sinica B 12 (2022) 1198–	50
USP20 as a super-enhancer-regulated gene drives T-ALL progression via HIF1A deubiquitination	49
Celastrol directly targets LRP1 to inhibit fibroblast-macrophage crosstalk and ameliorates psoriasis progression	49
PROTAC technology as a novel tool to identify the target of lathyrane diterpenoids	49
Spatial-resolved metabolomics reveals tissue-specific metabolic reprogramming in diabetic nephropathy by using mass spectrometry imaging	49
Rhizoma Drynariae-derived nanovesicles reverse osteoporosis by potentiating osteogenic differentiation of human bone marrow mesenchymal stem cells via targeting ERα signaling	49
The novel ER stress inducer Sec C triggers apoptosis by sulfating ER cysteine residues and degrading YAP via ER stress in pancreatic cancer cells	49
Cover Story	49
Single-domain antibodies as therapeutics for solid tumor treatment	49
mIgM-mediated splenic marginal zone B cells targeting of folic acid for immunological evasion	48
Harnessing the UDP-G/P2Y14R axis to promote liver regeneration in acute liver failure	48
Imaging the impact of sex and age on OATP function in humans: Consequences for whole-body pharmacokinetics and liver exposure	48
Avenanthramide A potentiates Bim-mediated antineoplastic properties of 5-fluorouracil via targeting KDM4C/MIR17HG/GSK-3β negative feedback loop in colorectal cancer	48
Analysis of new drug registration and review in China in 2021	48
Novel compound FLZ alleviates rotenone-induced PD mouse model by suppressing TLR4/MyD88/NF-κB pathway through microbiota–gut–brain axis	47
Unlocking the potential of the gut microbiome in liver regeneration: Benefits and mechanistic insights	47
Development of a novel 18F-labeled reversible-binding radioligand for imaging monoacylglycerol lipase with positron emission tomography	47
The ubiquitin–proteasome system: A potential target for the MASLD	47
Inhibition of CCT5-mediated asparagine biosynthesis and anti-PD-L1 produce synergistic antitumor effects in colorectal cancer	46
Personalized medicine of non-gene-specific chemotherapies for non-small cell lung cancer	46
A micro-sized vaccine based on recombinant Lactiplantibacillus plantarum fights against SARS-CoV-2 infection via intranasal immunization	46
Advancements and challenges in immunocytokines: A new arsenal against cancer	46
Author correction to “PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism” [Acta Pharm Sin B 13 (2023) 157–173]	46
Discovery of highly potent phosphodiesterase-1 inhibitors by a combined-structure free energy perturbation approach	45
Cover Story	45
Engineered tumor specific AAV for IL-12 delivery in ovarian cancer immunotherapy	45
Mucosal delivery of nanovaccine strategy against COVID-19 and its variants	44
Spatiotemporally responsive cascade bilayer microneedles integrating local glucose depletion and sustained nitric oxide release for accelerated diabetic wound healing	44
Precise nano-system-based drug delivery and synergistic therapy against androgen receptor-positive triple-negative breast cancer	44
High-throughput discovery of highly selective reversible hMAO-B inhibitors based on at-line nanofractionation	44
Unveiling the metabolic fate of drugs through metabolic reaction-based molecular networking	44
Palmitoylated SARM1 targeting P4HA1 promotes collagen deposition and myocardial fibrosis: A new target for anti-myocardial fibrosis	44
Non-apoptotic cell death-based cancer therapy: Molecular mechanism, pharmacological modulators, and nanomedicine	44
Discovery of novel 4-phenylquinazoline-based BRD4 inhibitors for cardiac fibrosis	43
Multi-functional vesicles improve Helicobacter pylori eradication by a comprehensive strategy based on complex pathological microenvironment	43
Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management	43
Discovery of novel exceptionally potent and orally active c-MET PROTACs for the treatment of tumors with MET alterations	43
Translating bacteriophage-derived depolymerases into antibacterial therapeutics: Challenges and prospects	43
Targeting RAF dimers in RAS mutant tumors: From biology to clinic	43
Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis	43
Locally producing antibacterial peptide to deplete intratumoral pathogen for preventing metastatic breast cancer	42
Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls	42
Cover Story	42
Selective type II TRK inhibitors overcome xDFG mutation mediated acquired resistance to the second-generation inhibitors selitrectinib and repotrectinib	42
Cover Story	42
Macrophage P2Y6R activation aggravates psoriatic inflammation through IL-27-mediated Th1 responses	41
AKR1C1 interacts with STAT3 to increase intracellular glutathione and confers resistance to oxaliplatin in colorectal cancer	41
Artificial intelligence in drug development for delirium and Alzheimer’s disease	41
Tranexamic acid-fatty alcohol polyoxyethylene ether conjugation/PVA foam for venous sclerotherapy via vascular damage and inhibiting plasmin system	41
Controlling antifungal activity with light: Optical regulation of fungal ergosterol biosynthetic pathway with photo-responsive CYP51 inhibitors	41
Alleviating experimental pulmonary hypertension via co-delivering FoxO1 stimulus and apoptosis activator to hyperproliferating pulmonary arteries	41
Amylovis-201 is a new dual-target ligand, acting as an anti-amyloidogenic compound and a potent agonist of the σ1 chaperone protein	41
Author correction to “Tumor-microenvironment activated duplex genome-editing nanoprodrug for sensitized near-infrared titania phototherapy” [Acta Pharm Sin B (2022) 4224–4234]	41
Transcription factor EHF interacting with coactivator AJUBA aggravates malignancy and acts as a therapeutic target for gastroesophageal adenocarcinoma	41
Cover Story	41
Dissecting the novel abilities of aripiprazole: The generation of anti-colorectal cancer effects by targeting Gαq via HTR2B	41
“Relative symmetry with electronegativity of different key-groups” strategy for MRGPRX2 antagonist design and its effect on antigen-induced pulmonary inflammation	41
Spatiotemporally resolved metabolomics and isotope tracing reveal CNS drug targets	41
l-[5-11C]Glutamine PET imaging noninvasively tracks dynamic responses of glutaminolysis in non-alcoholic steatohepatitis	41
Targeting the coronavirus membrane protein: a promising novel therapeutic strategy	41
Target-responsive subcellular catabolism analysis for early-stage antibody–drug conjugates screening and assessment	41
Development of a bacteria-nanosapper for the active delivery of ZIF-8 particles containing therapeutic genes for cancer immune therapy	41
Structures and functions of the MICOS: Pathogenesis and therapeutic implications in Alzheimer's disease	41
Genome editing of PAR2 through targeted delivery of CRISPR-Cas9 system for alleviating acute lung inflammation via ERK/NLRP3/IL-1β and NO/iNOS signalling	41
Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy	40
Mucosal vaccine delivery: A focus on the breakthrough of specific barriers	40
Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis	40
Full-profile pharmacokinetics, anticancer activity and toxicity of an extended release trivalent PEGylated irinotecan prodrug	40
Prediction of lipid nanoparticles for mRNA vaccines by the machine learning algorithm	40
Effects of small molecules on neurogenesis: Neuronal proliferation and differentiation	40
Intelligent lesion blood–brain barrier targeting nano-missiles for Alzheimer's disease treatment by anti-neuroinflammation and neuroprotection	39
Bile acids and coronavirus disease 2019	39
Application of computational methods in the drug discovery and development of Alzheimer’s disease	39
A multidimensional platform of patient-derived tumors identifies drug susceptibilities for clinical lenvatinib resistance	39
Benzimidazole and its derivatives as cancer therapeutics: The potential role from traditional to precision medicine	39
Targeting toll-like receptor 7 as a therapeutic development strategy for systemic lupus erythematosus	39
In vitro and in vivo correlation for lipid-based formulations: Current status and future perspectives	39
Recent progress of aptamer‒drug conjugates in cancer therapy	38