OOIR: Observatory of International Research

Papers

(The H4-Index of Acta Pharmaceutica Sinica B is 78. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
The cytoskeletal protein smoothelin maintains homologous recombination repair by stabilizing RAD51 in an HUWE1-dependent manner in colorectal cancer	1174
The progress and perspective of nanomedicine in modulating the tumor immune microenvironment	473
[18F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models	410
Research and development of Chinese anti-COVID-19 drugs	344
Discovery and development of brain-penetrant 18F-labeled radioligands for neuroimaging of the sigma-2 receptors	309
Drug discovery in China: A snapshot of recent progress	301
Rapid discovery of drug-introduced multiple organ dysfunction via NIR-II fluorescent imaging	275
Innovative discovery and mechanistic validation of HyT-PD ligands for selective CDK9-targeted protein degradation	265
The role of SARS-CoV-2 main protease in innate immune regulation: From molecular mechanisms to therapeutic implications	265
A5—A dual-target antiviral compound that rewrites the rules of influenza therapy	263
Polymer-assisted PD-L1 degradation and targeted photodynamic therapy synergize to suppress immunodeficient tumors	244
PAFR/Stat3 axis maintains the symbiotic ecosystem between tumor and stroma to facilitate tumor malignancy	236
Identification of a JAK–STAT–miR155HG positive feedback loop in regulating natural killer (NK) cells proliferation and effector functions	229
Rifamycin O as a novel CRBN ligand for targeted degradation of IKZF1/3 proteins in hematopoietic malignancies	225
Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia	212
Preclinical characterization and anti-RSV efficacy of an oral C-nucleoside derivative	205
Novel carbazole attenuates vascular remodeling through STAT3/CIAPIN1 signaling in vascular smooth muscle cells	204
Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis	195
Unravelling the target landscape of tranylcypromines for new drug discovery	174
Lycorine hydrochloride directly targets UBA1 to suppress cellular senescence	167
Identification of anti-Mycobacterium tuberculosis agents targeting the interaction of bacterial division proteins FtsZ and SepFe	166
Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer	156
Table of Contents	156
Allosterically activating SHP2 by oleanolic acid inhibits STAT3–Th17 axis for ameliorating colitis	150
Akkermansia muciniphila-derived acetate activates the hepatic AMPK/SIRT1/PGC-1α axis to alleviate ferroptosis in metabolic-associated fatty liver disease	149

Sequential dual-locking strategy using photoactivated Pt(IV)-based metallo-nano prodrug for enhanced chemotherapy and photodynamic efficacy by triggering ferroptosis and macrophage polarization	149
Oral administration of probiotic colony-like micro-nano system for immunoregulation of rheumatoid arthritis	148
Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin: Creation of an unnatural analogue with improved anticancer properties	146
Reductive stress—a common metabolic feature of obesity and cancer	144
Gasdermin D-mediated pyroptosis in myocardial ischemia and reperfusion injury: Cumulative evidence for future cardioprotective strategies	143
Cold exposure-induced β-hydroxybutyrate promotes brown fat mitochondrial lipid droplet contact to ameliorate fatty dysfunction and hepatic steatosis	143
A novel heterologous receptor-binding domain dodecamer universal mRNA vaccine against SARS-CoV-2 variants	133
Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism	129
Discovery and mechanism verification of first-in-class hydrophobic tagging-based degraders of HBV core protein	124
A novel shark VNAR antibody-based immunotoxin targeting TROP-2 for cancer therapy	119
Azvudine reduces the in-hospital mortality of COVID-19 patients: A retrospective cohort study	112
Free energy perturbation (FEP)-guided scaffold hopping	111
Spatial metabolomics highlights metabolic reprogramming in acute myeloid leukemia mice through creatine pathway	111
Spirohypertones A and B as potent antipsoriatics: Tumor necrosis factor-α inhibitors with unprecedented chemical architectures	110
Decoding the chromatin accessibility in Andrographis paniculata genome, a case study of genome-wide investigation of the cis-regulatory elements in medicinal plants	109
Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk	108
Regulation of histidine metabolism by Lactobacillus Reuteri mediates the pathogenesis and treatment of ischemic stroke	108
A novel inhibitor of N6-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities	106
Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice	105
Transformation of peptides to small molecules in medicinal chemistry: Challenges and opportunities	105
Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles	105
Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy	104
Two types of coumarins-specific enzymes complete the last missing steps in pyran- and furanocoumarins biosynthesis	103
Submicron-sized superantigen biomimetic liposomes: enhanced lung accumulation and synergistic chemoimmunotherapy	100
Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions	100
Free fatty acid receptor-4 regulates T-cell-mediated allogeneic reaction through activating an aryl hydrocarbon receptor pathway	99
Transferrin receptor-targeted immunostimulant for photodynamic immunotherapy against metastatic tumors through β-catenin/CREB interruption	99
Nanoparticle drug delivery system for the treatment of brain tumors: Breaching the blood–brain barrier	98
Melatonin alleviates alcoholic liver disease via EGFR–BRG1–TERT axis regulation	97
Ferroptosis meets cancer immunotherapy: Overcoming the crosstalk challenges through advanced drug delivery strategies	96
Table of Contents	93
High-efficient discovering the potent anti-Notum agents from herbal medicines for combating glucocorticoid-induced osteoporosis	93
FOXO3 mutation predicting gefitinib-induced hepatotoxicity in NSCLC patients through regulation of autophagy	92
Structure-based drug discovery of novel fused-pyrazolone carboxamide derivatives as potent and selective AXL inhibitors	90
Nucleic acid-based delivery system delivering platinum drugs cooperates with siRNA for potentiated chemo-immunotherapy by reducing phosphatidylserine exposure and activating the cGAS–STING pathway	88
Editor Profile: Guest Editor of Special Column on RNA Therapeutics and Drug Delivery Technologies for Medical Applications	88
CarsiDock-Cov: A deep learning-guided approach for automated covalent docking and screening	87
Commentary: The central lymphatic drainage in pharmacological, surgical and physical therapies of Alzheimer's disease	87
Design, synthesis, and antitumor activity of novel thioheterocyclic nucleoside derivatives by suppressing the c-MYC pathway	87
Deciphering the significant impact of natural glycosylation on human insulin	87
GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer	86
Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in non-alcoholic steatohepatitis patients	85
Bimetallic nanoparticles as cascade sensitizing amplifiers for low-dose and robust cancer radio-immunotherapy	84
Engineered cyclic peptide targeting ITGA5 disrupts tumor-stroma interaction to overcome desmoplasia and resistance in pancreatic ductal adenocarcinoma	83
Therapeutic potential of traditional Chinese medicine for the treatment of NAFLD: A promising drug Potentilla discolor Bunge	83
Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis	82
Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy	81
Nanoparticles (NPs)-mediated lncBCMA silencing to promote eEF1A1 ubiquitination and suppress breast cancer growth and metastasis	81
The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation	80
Five trends of China's pharmaceutical industry in 2022	80

Remembering your A, B, C's: Alzheimer's disease and ABCA1	80
NIR-II-activated whole-cell vaccine with ultra-efficient semiconducting diradical oligomers for breast carcinoma growth and metastasis inhibition	79
Suppressing Wnt signaling of the blood‒tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases	79
Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation	78
Immune cell membrane-based biomimetic nanomedicine for treating cancer metastasis	78
Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein (RNP) to inhibit herpes simplex virus1 infection in vitro and in vivo	78