OOIR: Observatory of International Research

Papers

(The H4-Index of Acta Pharmaceutica Sinica B is 73. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Table of Contents	662
Cover Story	343
A novel PI3K inhibitor XH30 suppresses orthotopic glioblastoma and brain metastasis in mice models	299
EHMT2 promotes tumorigenesis in GNAQ/11-mutant uveal melanoma via ARHGAP29-mediated RhoA pathway	295
Novel carbazole attenuates vascular remodeling through STAT3/CIAPIN1 signaling in vascular smooth muscle cells	284
Iron and siRNA co-encapsulated ferritin nanocages induce ferroptosis synergistically for cancer therapy	265
Regulation of histidine metabolism by Lactobacillus Reuteri mediates the pathogenesis and treatment of ischemic stroke	260
Extracellular vesicles deliver thioredoxin to rescue stem cells from senescence and intervertebral disc degeneration via a feed-forward circuit of the NRF2/AP-1 composite pathway	245
Remodeling tumor immunosuppressive microenvironment through dual activation of immunogenic panoptosis and ferroptosis by H2S-amplified nanoformulation to enhance cancer immunotherapy	196
Cover Story	194
Glutamate-releasing BEST1 channel is a new target for neuroprotection against ischemic stroke with wide time window	174
Coating with flexible DNA network enhanced T-cell activation and tumor killing for adoptive cell therapy	171
Emerging non-antibody‒drug conjugates (non-ADCs) therapeutics of toxins for cancer treatment	171
A novel biological sources consistency evaluation method reveals high level of biodiversity within wild natural medicine: A case study of Amynthas earthworms as “Guang Dilong”	169
Cover Story	166
Fenofibrate-promoted hepatomegaly and liver regeneration are PPARα-dependent and partially related to the YAP pathway	165
Sequential dual-locking strategy using photoactivated Pt(IV)-based metallo-nano prodrug for enhanced chemotherapy and photodynamic efficacy by triggering ferroptosis and macrophage polarization	157
Table of Contents	155
The clinical antiprotozoal drug nitazoxanide and its metabolite tizoxanide extend Caenorhabditis elegans lifespan and healthspan	155
Spirohypertones A and B as potent antipsoriatics: Tumor necrosis factor-α inhibitors with unprecedented chemical architectures	154
Harnessing the cyclization strategy for new drug discovery	153
Self-assembled multifunctional nanotheranostics against circulating tumor clusters in metastatic breast cancer	152
Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia	150
A four-protein metabolon assembled by a small peptide protein creates the pentacyclic carbonate ring of aldgamycins	150
Preclinical studies of the triazolo[1,5-a]pyrimidine derivative WS-716 as a highly potent, specific and orally active P-glycoprotein (P-gp) inhibitor	150

Ultra-short-course and intermittent TB47-containing oral regimens produce stable cure against Buruli ulcer in a murine model and prevent the emergence of resistance for Mycobacterium ulcerans	146
Peroxidase from foxtail millet bran exerts anti-colorectal cancer activity via targeting cell-surface GRP78 to inactivate STAT3 pathway	143
Synthesis and evaluation of TSPO-targeting radioligand [18F]F-TFQC for PET neuroimaging in epileptic rats	135
Facile synthesis of insulin fusion derivatives through sortase A ligation	133
Guest Editors of Special Column on Drug Targets and Drug Development for Alzheimer’s Disease	131
ACAT1 deficiency in myeloid cells promotes glioblastoma progression by enhancing the accumulation of myeloid-derived suppressor cells	128
Drug discovery in China: A snapshot of recent progress	127
Reconstitution of biosynthetic pathway for mushroom-derived cyathane diterpenes in yeast and generation of new “non-natural” analogues	120
Activating Connexin43 gap junctions primes adipose tissue for therapeutic intervention	120
In vivo testing of mucus-permeating nanoparticles for oral insulin delivery using Caenorhabditis elegans as a model under hyperglycemic conditions	119
Editor Profiles: Guest Editors of Special Column on A New Era of Nanobiomaterial-based Drug Delivery	119
Directly targeting BAX for drug discovery: Therapeutic opportunities and challenges	116
HR121 targeting HR2 domain in S2 subunit of spike protein can serve as a broad-spectrum SARS-CoV-2 inhibitor via intranasal administration	115
Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases	112
Critical involvement of lysyl oxidase in seizure-induced neuronal damage through ERK-Alox5-dependent ferroptosis and its therapeutic implications	109
Construction and characterization of a humanized SLCO1B1 rat model with its application in evaluating the uptake of different statins	108
Editor Profiles: Guest Editors of Special Column on Antiviral Drug Discovery and Pharmacology	107
Table of Contents	107
Commentary: Indirect action pattern: A remote and cross-organ pharmacological mechanism for drug innovation	101
From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution	99
Editorial of Special Column “Novel Peptides and Peptidomimetics in Drug Discovery”	99
Commentary: A nearly forgotten class of anti-inflammatory lipid molecules in central nervous system	98
Development of a highly-specific 18F-labeled irreversible positron emission tomography tracer for monoacylglycerol lipase mapping	98
Cover Story	97
Transformation of peptides to small molecules in medicinal chemistry: Challenges and opportunities	95
Spatial metabolomics highlights metabolic reprogramming in acute myeloid leukemia mice through creatine pathway	94
Reprogramming tumor-associated macrophages and inhibiting tumor neovascularization by targeting MANF–HSF1–HSP70-1 pathway: An effective treatment for hepatocellular carcinoma	93
Metabolic basis of solute carrier transporters in treatment of type 2 diabetes mellitus	92
Targeted isolation of antiviral cinnamoylphloroglucinol-terpene adducts from Cleistocalyx operculatus by building blocks-based molecular networking approach	91
Single-cell transcriptomics reveals the ameliorative effect of rosmarinic acid on diabetic nephropathy-induced kidney injury by modulating oxidative stress and inflammation	88
The emerging tumor microbe microenvironment: From delineation to multidisciplinary approach-based interventions	87
Research and development of Chinese anti-COVID-19 drugs	86
Endoplasmic reticulum-targeted delivery of celastrol and PD-L1 siRNA for reinforcing immunogenic cell death and potentiating cancer immunotherapy	85
Multidimensional autophagy nano-regulator boosts Alzheimer's disease treatment by improving both extra/intraneuronal homeostasis	84
Structural repurposing of SGLT2 inhibitor empagliflozin for strengthening anti-heart failure activity with lower glycosuria	84
A reporter gene assay for determining the biological activity of therapeutic antibodies targeting TIGIT	82
A potentially serious adverse effect of GLP-1 receptor agonists	82
Activation of PXR causes drug interactions with Paxlovid in transgenic mice	82
SMIP-30, a potent and selective PPM1A inhibitor with potential to treat tuberculosis	81
Environmental toxicant-induced maladaptive mitochondrial changes: A potential unifying mechanism in fatty liver disease?	80
Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma	77
The regulatory mechanisms and inhibitors of isocitrate dehydrogenase 1 in cancer	77
A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors	77
On-demand integrated nano-engager converting cold tumors to hot via increased DNA damage and dual immune checkpoint inhibition	76
Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy	75
PXR activation impairs hepatic glucose metabolism partly via inhibiting the HNF4α–GLUT2 pathway	74
Discovery and development of brain-penetrant 18F-labeled radioligands for neuroimaging of the sigma-2 receptors	74
Pharmaceutical applications of framework nucleic acids	74
Overcoming Mycobacterium tuberculosis through small molecule inhibitors to break down cell wall synthesis	73