OOIR: Observatory of International Research

Papers

(The H4-Index of Acta Pharmaceutica Sinica B is 79. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Identification of a JAK–STAT–miR155HG positive feedback loop in regulating natural killer (NK) cells proliferation and effector functions	1486
Rifamycin O as a novel CRBN ligand for targeted degradation of IKZF1/3 proteins in hematopoietic malignancies	518
Lycorine hydrochloride directly targets UBA1 to suppress cellular senescence	417
Table of Contents	360
Innovative discovery and mechanistic validation of HyT-PD ligands for selective CDK9-targeted protein degradation	295
A5—A dual-target antiviral compound that rewrites the rules of influenza therapy	274
Discovery and mechanism verification of first-in-class hydrophobic tagging-based degraders of HBV core protein	239
Rapid discovery of drug-introduced multiple organ dysfunction via NIR-II fluorescent imaging	219
Structural insights into pterocarpan reductases unveil a universal ring-opening mechanism in plant biosynthesis of 4-(furan-2-yl) phenol derivatives	211
Transformation of peptides to small molecules in medicinal chemistry: Challenges and opportunities	208
Novel carbazole attenuates vascular remodeling through STAT3/CIAPIN1 signaling in vascular smooth muscle cells	206
Oral administration of probiotic colony-like micro-nano system for immunoregulation of rheumatoid arthritis	203
Cold exposure-induced β-hydroxybutyrate promotes brown fat mitochondrial lipid droplet contact to ameliorate fatty dysfunction and hepatic steatosis	186
A novel shark VNAR antibody-based immunotoxin targeting TROP-2 for cancer therapy	183
Azvudine reduces the in-hospital mortality of COVID-19 patients: A retrospective cohort study	180
Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia	175
Polymer-assisted PD-L1 degradation and targeted photodynamic therapy synergize to suppress immunodeficient tumors	169
Development of bacterial sonosensitizer hybrid systems to enhance cancer sono-immunotherapy	168
Soft cell-derived hybrid microparticles with platelet decoys for enhanced cancer chemotherapy	147
Allosterically activating SHP2 by oleanolic acid inhibits STAT3–Th17 axis for ameliorating colitis	144
Distinctive molecular architectures of Gq- and Gi-coupled GLP-1 receptors	142
Research and development of Chinese anti-COVID-19 drugs	141
Paeoniflorin alleviates hypobaric hypoxia-triggered lung injury through targeting MEK2 to modulate ERK2–SGK1 signaling	136
The role of SARS-CoV-2 main protease in innate immune regulation: From molecular mechanisms to therapeutic implications	136
Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles	131

The progress and perspective of nanomedicine in modulating the tumor immune microenvironment	128
TeroACT: A terpenoid bioactivity landscape and discovery platform	126
Unnatural amino acid-based miniPROTACs enable efficient oncoprotein degradation	126
The cytoskeletal protein smoothelin maintains homologous recombination repair by stabilizing RAD51 in an HUWE1-dependent manner in colorectal cancer	125
PAFR/Stat3 axis maintains the symbiotic ecosystem between tumor and stroma to facilitate tumor malignancy	124
Decoding the chromatin accessibility in Andrographis paniculata genome, a case study of genome-wide investigation of the cis-regulatory elements in medicinal plants	123
Unravelling the target landscape of tranylcypromines for new drug discovery	121
Regulation of histidine metabolism by Lactobacillus Reuteri mediates the pathogenesis and treatment of ischemic stroke	118
A novel heterologous receptor-binding domain dodecamer universal mRNA vaccine against SARS-CoV-2 variants	112
Drug discovery in China: A snapshot of recent progress	112
Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer	111
Two types of coumarins-specific enzymes complete the last missing steps in pyran- and furanocoumarins biosynthesis	109
Liver–pancreas communication in disease and drug development	105
Spatial metabolomics highlights metabolic reprogramming in acute myeloid leukemia mice through creatine pathway	104
A new approach to discovering a broad-spectrum anti-respiratory virus drug: Tubeimoside II modulates host factor PACT to potentiate the RIG-I antiviral pathway	104
Spirohypertones A and B as potent antipsoriatics: Tumor necrosis factor-α inhibitors with unprecedented chemical architectures	103
Gasdermin D-mediated pyroptosis in myocardial ischemia and reperfusion injury: Cumulative evidence for future cardioprotective strategies	103
Identification of anti-Mycobacterium tuberculosis agents targeting the interaction of bacterial division proteins FtsZ and SepFe	103
Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis	103
Reductive stress—a common metabolic feature of obesity and cancer	102
Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin: Creation of an unnatural analogue with improved anticancer properties	101
Preclinical characterization and anti-RSV efficacy of an oral C-nucleoside derivative	100
Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism	99
Sequential dual-locking strategy using photoactivated Pt(IV)-based metallo-nano prodrug for enhanced chemotherapy and photodynamic efficacy by triggering ferroptosis and macrophage polarization	99
Akkermansia muciniphila-derived acetate activates the hepatic AMPK/SIRT1/PGC-1α axis to alleviate ferroptosis in metabolic-associated fatty liver disease	98
Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in non-alcoholic steatohepatitis patients	97
Submicron-sized superantigen biomimetic liposomes: enhanced lung accumulation and synergistic chemoimmunotherapy	97
Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice	97
Unlocking T cell exhaustion: Insights and implications for CAR-T cell therapy	95
Deciphering the significant impact of natural glycosylation on human insulin	95
The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation	94
High-throughput ligand discovery in living cells using the cellular protein stability enhancement assay	94
Orally delivered exosome-like nanoparticles from Tetrastigma hemsleyanum Diels et Gilg remodel the gut–tumor immune axis to activate antitumor immunity	94
Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein (RNP) to inhibit herpes simplex virus1 infection in vitro and in vivo	93
Structure-based drug discovery of novel fused-pyrazolone carboxamide derivatives as potent and selective AXL inhibitors	93
Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease	92
Deep learning-driven discovery and mechanism of action study of a minimalist conopeptide targeting α7 nicotinic acetylcholine receptor	92
High-efficient discovering the potent anti-Notum agents from herbal medicines for combating glucocorticoid-induced osteoporosis	92
GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer	90
Free fatty acid receptor-4 regulates T-cell-mediated allogeneic reaction through activating an aryl hydrocarbon receptor pathway	89
Improved prebiotic-based “shield” equipped probiotics for enhanced colon cancer therapy by polarizing M1 macrophages and regulating intestinal microbiota	89
Suppressing Wnt signaling of the blood‒tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases	86
Editor Profile: Guest Editor of Special Column on RNA Therapeutics and Drug Delivery Technologies for Medical Applications	86
Nanoparticles (NPs)-mediated lncBCMA silencing to promote eEF1A1 ubiquitination and suppress breast cancer growth and metastasis	86
Table of Contents	86
The role of bacteria and its derived biomaterials in cancer radiotherapy	85
NIR-II-activated whole-cell vaccine with ultra-efficient semiconducting diradical oligomers for breast carcinoma growth and metastasis inhibition	85
Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation	85
Cover Story	83
“Weibing” in traditional Chinese medicine—biological basis and mathematical representation of disease-susceptible state	83

A preclinical and first-in-human study of superstable homogeneous radiolipiodol for revolutionizing interventional diagnosis and treatment of hepatocellular carcinoma	82
Targeting RSK2 reverses endocrine resistance in ER-positive breast cancer via inhibiting the c-Myc–ERBB4 signaling pathway	81
Aberrant astroglial Kir4.1 activation in the anterior cingulate cortex disrupts neuronal excitability and social behavior	81
Editor Profiles: Guest Editors of Special Column on Hot Topic Reviews in Drug (II)	79