OOIR: Observatory of International Research

Papers

(The H4-Index of Acta Pharmaceutica Sinica B is 78. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Rifamycin O as a novel CRBN ligand for targeted degradation of IKZF1/3 proteins in hematopoietic malignancies	608
Lycorine hydrochloride directly targets UBA1 to suppress cellular senescence	448
Table of Contents	375
A5—A dual-target antiviral compound that rewrites the rules of influenza therapy	257
Novel carbazole attenuates vascular remodeling through STAT3/CIAPIN1 signaling in vascular smooth muscle cells	246
A novel shark VNAR antibody-based immunotoxin targeting TROP-2 for cancer therapy	239
Azvudine reduces the in-hospital mortality of COVID-19 patients: A retrospective cohort study	220
Distinctive molecular architectures of Gq- and Gi-coupled GLP-1 receptors	219
Research and development of Chinese anti-COVID-19 drugs	214
Unnatural amino acid-based miniPROTACs enable efficient oncoprotein degradation	197
The cytoskeletal protein smoothelin maintains homologous recombination repair by stabilizing RAD51 in an HUWE1-dependent manner in colorectal cancer	194
PAFR/Stat3 axis maintains the symbiotic ecosystem between tumor and stroma to facilitate tumor malignancy	193
Unravelling the target landscape of tranylcypromines for new drug discovery	176
Drug discovery in China: A snapshot of recent progress	175
Liver–pancreas communication in disease and drug development	165
Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin: Creation of an unnatural analogue with improved anticancer properties	153
Paeoniflorin alleviates hypobaric hypoxia-triggered lung injury through targeting MEK2 to modulate ERK2–SGK1 signaling	146
A new approach to discovering a broad-spectrum anti-respiratory virus drug: Tubeimoside II modulates host factor PACT to potentiate the RIG-I antiviral pathway	145
Identification of anti-Mycobacterium tuberculosis agents targeting the interaction of bacterial division proteins FtsZ and SepFe	144
Preclinical characterization and anti-RSV efficacy of an oral C-nucleoside derivative	135
Structural insights into pterocarpan reductases unveil a universal ring-opening mechanism in plant biosynthesis of 4-(furan-2-yl) phenol derivatives	132
Gasdermin D-mediated pyroptosis in myocardial ischemia and reperfusion injury: Cumulative evidence for future cardioprotective strategies	131
Spatial metabolomics highlights metabolic reprogramming in acute myeloid leukemia mice through creatine pathway	129
Development of bacterial sonosensitizer hybrid systems to enhance cancer sono-immunotherapy	129
Spirohypertones A and B as potent antipsoriatics: Tumor necrosis factor-α inhibitors with unprecedented chemical architectures	129

Table of Contents	128
Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice	122
Decoding the chromatin accessibility in Andrographis paniculata genome, a case study of genome-wide investigation of the cis-regulatory elements in medicinal plants	122
Soft cell-derived hybrid microparticles with platelet decoys for enhanced cancer chemotherapy	119
Two types of coumarins-specific enzymes complete the last missing steps in pyran- and furanocoumarins biosynthesis	118
Oral administration of probiotic colony-like micro-nano system for immunoregulation of rheumatoid arthritis	116
Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia	115
TeroACT: A terpenoid bioactivity landscape and discovery platform	114
Reductive stress—a common metabolic feature of obesity and cancer	114
Rapid discovery of drug-introduced multiple organ dysfunction via NIR-II fluorescent imaging	113
The progress and perspective of nanomedicine in modulating the tumor immune microenvironment	112
Molecular mechanisms, crosstalk and therapeutic potential of novel acylation modifications in cardiovascular and cerebrovascular diseases	112
Identification of a JAK–STAT–miR155HG positive feedback loop in regulating natural killer (NK) cells proliferation and effector functions	112
A novel heterologous receptor-binding domain dodecamer universal mRNA vaccine against SARS-CoV-2 variants	109
Sequential dual-locking strategy using photoactivated Pt(IV)-based metallo-nano prodrug for enhanced chemotherapy and photodynamic efficacy by triggering ferroptosis and macrophage polarization	108
Molecular architecture responsible for specific inhibition of oncogenic PI3Kα mutants by RLY-2608 and STX-478	108
Cold exposure-induced β-hydroxybutyrate promotes brown fat mitochondrial lipid droplet contact to ameliorate fatty dysfunction and hepatic steatosis	107
A probiotic–drug cascade system for inflammatory bowel disease via tryptophan metabolism and gut microbiome remodeling	106
Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer	103
Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles	102
Discovery and mechanism verification of first-in-class hydrophobic tagging-based degraders of HBV core protein	101
Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism	101
Allosterically activating SHP2 by oleanolic acid inhibits STAT3–Th17 axis for ameliorating colitis	101
Akkermansia muciniphila-derived acetate activates the hepatic AMPK/SIRT1/PGC-1α axis to alleviate ferroptosis in metabolic-associated fatty liver disease	100
Transformation of peptides to small molecules in medicinal chemistry: Challenges and opportunities	98
Innovative discovery and mechanistic validation of HyT-PD ligands for selective CDK9-targeted protein degradation	98
The role of SARS-CoV-2 main protease in innate immune regulation: From molecular mechanisms to therapeutic implications	98
BD2-selective BRD4 inhibitor ZX29 mitigates myocardial ischemia–reperfusion injury via BRD4–YY1–NCOA4 axis disruption and ferroptosis inhibition	94
Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis	94
Regulation of histidine metabolism by Lactobacillus Reuteri mediates the pathogenesis and treatment of ischemic stroke	93
Polymer-assisted PD-L1 degradation and targeted photodynamic therapy synergize to suppress immunodeficient tumors	93
Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in non-alcoholic steatohepatitis patients	92
Submicron-sized superantigen biomimetic liposomes: enhanced lung accumulation and synergistic chemoimmunotherapy	92
Structure-based drug discovery of novel fused-pyrazolone carboxamide derivatives as potent and selective AXL inhibitors	91
Suppressing Wnt signaling of the blood‒tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases	90
Free fatty acid receptor-4 regulates T-cell-mediated allogeneic reaction through activating an aryl hydrocarbon receptor pathway	90
GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer	90
Table of Contents	88
Editor Profile: Guest Editor of Special Column on RNA Therapeutics and Drug Delivery Technologies for Medical Applications	87
Cover Story	86
Editor Profiles: Guest Editors of Special Column on Hot Topic Reviews in Drug (II)	85
Aberrant astroglial Kir4.1 activation in the anterior cingulate cortex disrupts neuronal excitability and social behavior	85
FOXO3 mutation predicting gefitinib-induced hepatotoxicity in NSCLC patients through regulation of autophagy	84
Five trends of China's pharmaceutical industry in 2022	83
Structural biology of HIV-1 reverse transcriptase allosteric inhibitors for drug design	83
NIR-II-activated whole-cell vaccine with ultra-efficient semiconducting diradical oligomers for breast carcinoma growth and metastasis inhibition	82
Engineered cyclic peptide targeting ITGA5 disrupts tumor–stroma interaction to overcome desmoplasia and resistance in pancreatic ductal adenocarcinoma	82
“Weibing” in traditional Chinese medicine—biological basis and mathematical representation of disease-susceptible state	82
Immune cell membrane-based biomimetic nanomedicine for treating cancer metastasis	81
Nucleic acid-based delivery system delivering platinum drugs cooperates with siRNA for potentiated chemo-immunotherapy by reducing phosphatidylserine exposure and activating the cGAS–STING pathway	80

Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation	79
Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease	79
Transferrin receptor-targeted immunostimulant for photodynamic immunotherapy against metastatic tumors through β-catenin/CREB interruption	78
Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis	78