OOIR: Observatory of International Research

Papers

(The H4-Index of Acta Pharmaceutica Sinica B is 79. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
A novel heterologous receptor-binding domain dodecamer universal mRNA vaccine against SARS-CoV-2 variants	851
Discovery and mechanism verification of first-in-class hydrophobic tagging-based degraders of HBV core protein	422
Editorial of Special Column “Novel Peptides and Peptidomimetics in Drug Discovery”	353
Drug discovery in China: A snapshot of recent progress	347
Research and development of Chinese anti-COVID-19 drugs	340
Sequential dual-locking strategy using photoactivated Pt(IV)-based metallo-nano prodrug for enhanced chemotherapy and photodynamic efficacy by triggering ferroptosis and macrophage polarization	318
[18F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models	313
Decoding the chromatin accessibility in Andrographis paniculata genome, a case study of genome-wide investigation of the cis-regulatory elements in medicinal plants	243
Extensive expansion of the chemical diversity of fusidane-type antibiotics using a stochastic combinational strategy	239
Identification of a JAK–STAT–miR155HG positive feedback loop in regulating natural killer (NK) cells proliferation and effector functions	234
Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk	209
Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer	207
Reductive stress—a common metabolic feature of obesity and cancer	205
Discovery and development of brain-penetrant 18F-labeled radioligands for neuroimaging of the sigma-2 receptors	205
Reconstitution of biosynthetic pathway for mushroom-derived cyathane diterpenes in yeast and generation of new “non-natural” analogues	203
Spatial metabolomics highlights metabolic reprogramming in acute myeloid leukemia mice through creatine pathway	202
Multi-omics approaches identify SF3B3 and SIRT3 as candidate autophagic regulators and druggable targets in invasive breast carcinoma	196
Akkermansia muciniphila-derived acetate activates the hepatic AMPK/SIRT1/PGC-1α axis to alleviate ferroptosis in metabolic-associated fatty liver disease	194
Allosterically activating SHP2 by oleanolic acid inhibits STAT3–Th17 axis for ameliorating colitis	185
A novel shark VNAR antibody-based immunotoxin targeting TROP-2 for cancer therapy	182
Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions	182
Spirohypertones A and B as potent antipsoriatics: Tumor necrosis factor-α inhibitors with unprecedented chemical architectures	180
Regulation of histidine metabolism by Lactobacillus Reuteri mediates the pathogenesis and treatment of ischemic stroke	177
Novel carbazole attenuates vascular remodeling through STAT3/CIAPIN1 signaling in vascular smooth muscle cells	175
Lycorine hydrochloride directly targets UBA1 to suppress cellular senescence	169

Gasdermin D-mediated pyroptosis in myocardial ischemia and reperfusion injury: Cumulative evidence for future cardioprotective strategies	166
Free energy perturbation (FEP)-guided scaffold hopping	165
MCDB: A comprehensive curated mitotic catastrophe database for retrieval, protein sequence alignment, and target prediction	164
Identification of anti-Mycobacterium tuberculosis agents targeting the interaction of bacterial division proteins FtsZ and SepFe	160
Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy	159
Two types of coumarins-specific enzymes complete the last missing steps in pyran- and furanocoumarins biosynthesis	153
Unravelling the target landscape of tranylcypromines for new drug discovery	147
A novel inhibitor of N6-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities	140
Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin: Creation of an unnatural analogue with improved anticancer properties	140
Role of CD8+ T lymphocyte cells: Interplay with stromal cells in tumor microenvironment	138
PAFR/Stat3 axis maintains the symbiotic ecosystem between tumor and stroma to facilitate tumor malignancy	136
Coating with flexible DNA network enhanced T-cell activation and tumor killing for adoptive cell therapy	132
Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia	130
Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice	128
Functional identification of the terpene synthase family involved in diterpenoid alkaloids biosynthesis in Aconitum carmichaelii	124
Azvudine reduces the in-hospital mortality of COVID-19 patients: A retrospective cohort study	124
Transformation of peptides to small molecules in medicinal chemistry: Challenges and opportunities	121
Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles	115
Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism	114
An update on oral drug delivery via intestinal lymphatic transport	114
Editor Profile: Guest Editor of Special Column on RNA Therapeutics and Drug Delivery Technologies for Medical Applications	113
Five trends of China's pharmaceutical industry in 2022	112
Cover Story	111
FOXO3 mutation predicting gefitinib-induced hepatotoxicity in NSCLC patients through regulation of autophagy	110
Structure-based drug discovery of novel fused-pyrazolone carboxamide derivatives as potent and selective AXL inhibitors	109
Recent advances in developing small-molecule inhibitors against SARS-CoV-2	108
Remembering your A, B, C's: Alzheimer's disease and ABCA1	107
Nanoparticle drug delivery system for the treatment of brain tumors: Breaching the blood–brain barrier	106
Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy	105
Nanoparticles (NPs)-mediated lncBCMA silencing to promote eEF1A1 ubiquitination and suppress breast cancer growth and metastasis	104
“Weibing” in traditional Chinese medicine—biological basis and mathematical representation of disease-susceptible state	104
A preclinical and first-in-human study of superstable homogeneous radiolipiodol for revolutionizing interventional diagnosis and treatment of hepatocellular carcinoma	101
Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells	100
Commentary: The central lymphatic drainage in pharmacological, surgical and physical therapies of Alzheimer's disease	100
Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in non-alcoholic steatohepatitis patients	99
Bimetallic nanoparticles as cascade sensitizing amplifiers for low-dose and robust cancer radio-immunotherapy	96
The role of bacteria and its derived biomaterials in cancer radiotherapy	93
Energy metabolism disorders and potential therapeutic drugs in heart failure	92
Free fatty acid receptor-4 regulates T-cell-mediated allogeneic reaction through activating an aryl hydrocarbon receptor pathway	91
Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis	91
Transferrin receptor-targeted immunostimulant for photodynamic immunotherapy against metastatic tumors through β-catenin/CREB interruption	90
Melatonin alleviates alcoholic liver disease via EGFR–BRG1–TERT axis regulation	90
NIR-II-activated whole-cell vaccine with ultra-efficient semiconducting diradical oligomers for breast carcinoma growth and metastasis inhibition	90
The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation	90
Unlocking T cell exhaustion: Insights and implications for CAR-T cell therapy	89
Suppressing Wnt signaling of the blood‒tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases	87
Astaxanthine attenuates cisplatin ototoxicity in vitro and protects against cisplatin-induced hearing loss in vivo	87
GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer	86
Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation	86
Therapeutic potential of traditional Chinese medicine for the treatment of NAFLD: A promising drug Potentilla discolor Bunge	84

Insights into therapeutic peptides in the cancer-immunity cycle: Update and challenges	84
Development of Chinese herbal medicine for sensorineural hearing loss	82
Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein (RNP) to inhibit herpes simplex virus1 infection in vitro and in vivo	81
Engineered nanoparticles for precise targeted drug delivery and enhanced therapeutic efficacy in cancer immunotherapy	81