OOIR: Observatory of International Research

Papers

(The H4-Index of Acta Pharmaceutica Sinica B is 80. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Identification of a JAK–STAT–miR155HG positive feedback loop in regulating natural killer (NK) cells proliferation and effector functions	1438
Decoding the chromatin accessibility in Andrographis paniculata genome, a case study of genome-wide investigation of the cis-regulatory elements in medicinal plants	476
Rifamycin O as a novel CRBN ligand for targeted degradation of IKZF1/3 proteins in hematopoietic malignancies	399
Unravelling the target landscape of tranylcypromines for new drug discovery	353
Drug discovery in China: A snapshot of recent progress	310
Lycorine hydrochloride directly targets UBA1 to suppress cellular senescence	291
Table of Contents	264
Innovative discovery and mechanistic validation of HyT-PD ligands for selective CDK9-targeted protein degradation	233
A5—A dual-target antiviral compound that rewrites the rules of influenza therapy	212
Discovery and mechanism verification of first-in-class hydrophobic tagging-based degraders of HBV core protein	206
TeroACT: A terpenoid bioactivity landscape and discovery platform	201
Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis	198
Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism	195
Rapid discovery of drug-introduced multiple organ dysfunction via NIR-II fluorescent imaging	178
Identification of anti-Mycobacterium tuberculosis agents targeting the interaction of bacterial division proteins FtsZ and SepFe	177
Transformation of peptides to small molecules in medicinal chemistry: Challenges and opportunities	175
Structural insights into pterocarpan reductases unveil a universal ring-opening mechanism in plant biosynthesis of 4-(furan-2-yl) phenol derivatives	175
Novel carbazole attenuates vascular remodeling through STAT3/CIAPIN1 signaling in vascular smooth muscle cells	173
The cytoskeletal protein smoothelin maintains homologous recombination repair by stabilizing RAD51 in an HUWE1-dependent manner in colorectal cancer	165
Preclinical characterization and anti-RSV efficacy of an oral C-nucleoside derivative	165
Oral administration of probiotic colony-like micro-nano system for immunoregulation of rheumatoid arthritis	143
Cold exposure-induced β-hydroxybutyrate promotes brown fat mitochondrial lipid droplet contact to ameliorate fatty dysfunction and hepatic steatosis	139
A novel shark VNAR antibody-based immunotoxin targeting TROP-2 for cancer therapy	134
Azvudine reduces the in-hospital mortality of COVID-19 patients: A retrospective cohort study	131
A novel heterologous receptor-binding domain dodecamer universal mRNA vaccine against SARS-CoV-2 variants	130

PAFR/Stat3 axis maintains the symbiotic ecosystem between tumor and stroma to facilitate tumor malignancy	130
Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles	130
The progress and perspective of nanomedicine in modulating the tumor immune microenvironment	125
Reductive stress—a common metabolic feature of obesity and cancer	122
Regulation of histidine metabolism by Lactobacillus Reuteri mediates the pathogenesis and treatment of ischemic stroke	121
The role of SARS-CoV-2 main protease in innate immune regulation: From molecular mechanisms to therapeutic implications	121
Paeoniflorin alleviates hypobaric hypoxia-triggered lung injury through targeting MEK2 to modulate ERK2–SGK1 signaling	120
Polymer-assisted PD-L1 degradation and targeted photodynamic therapy synergize to suppress immunodeficient tumors	119
Development of bacterial sonosensitizer hybrid systems to enhance cancer sono-immunotherapy	117
Unnatural amino acid-based miniPROTACs enable efficient oncoprotein degradation	117
Liver–pancreas communication in disease and drug development	116
Soft cell-derived hybrid microparticles with platelet decoys for enhanced cancer chemotherapy	113
A new approach to discovering a broad-spectrum anti-respiratory virus drug: Tubeimoside II modulates host factor PACT to potentiate the RIG-I antiviral pathway	107
Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin: Creation of an unnatural analogue with improved anticancer properties	106
Allosterically activating SHP2 by oleanolic acid inhibits STAT3–Th17 axis for ameliorating colitis	103
Distinctive molecular architectures of Gq- and Gi-coupled GLP-1 receptors	102
Sequential dual-locking strategy using photoactivated Pt(IV)-based metallo-nano prodrug for enhanced chemotherapy and photodynamic efficacy by triggering ferroptosis and macrophage polarization	101
Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia	101
Research and development of Chinese anti-COVID-19 drugs	101
Spirohypertones A and B as potent antipsoriatics: Tumor necrosis factor-α inhibitors with unprecedented chemical architectures	101
Spatial metabolomics highlights metabolic reprogramming in acute myeloid leukemia mice through creatine pathway	100
Akkermansia muciniphila-derived acetate activates the hepatic AMPK/SIRT1/PGC-1α axis to alleviate ferroptosis in metabolic-associated fatty liver disease	100
Two types of coumarins-specific enzymes complete the last missing steps in pyran- and furanocoumarins biosynthesis	99
Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer	98
Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice	97
Gasdermin D-mediated pyroptosis in myocardial ischemia and reperfusion injury: Cumulative evidence for future cardioprotective strategies	96
Submicron-sized superantigen biomimetic liposomes: enhanced lung accumulation and synergistic chemoimmunotherapy	96
Deciphering the significant impact of natural glycosylation on human insulin	95
Design, synthesis, and antitumor activity of novel thioheterocyclic nucleoside derivatives by suppressing the c-MYC pathway	94
Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in non-alcoholic steatohepatitis patients	94
FOXO3 mutation predicting gefitinib-induced hepatotoxicity in NSCLC patients through regulation of autophagy	93
Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein (RNP) to inhibit herpes simplex virus1 infection in vitro and in vivo	93
“Weibing” in traditional Chinese medicine—biological basis and mathematical representation of disease-susceptible state	92
Improved prebiotic-based “shield” equipped probiotics for enhanced colon cancer therapy by polarizing M1 macrophages and regulating intestinal microbiota	91
Ferroptosis meets cancer immunotherapy: Overcoming the crosstalk challenges through advanced drug delivery strategies	90
Table of Contents	89
Editor Profile: Guest Editor of Special Column on RNA Therapeutics and Drug Delivery Technologies for Medical Applications	89
Structure-based drug discovery of novel fused-pyrazolone carboxamide derivatives as potent and selective AXL inhibitors	89
Transferrin receptor-targeted immunostimulant for photodynamic immunotherapy against metastatic tumors through β-catenin/CREB interruption	88
Engineered cyclic peptide targeting ITGA5 disrupts tumor–stroma interaction to overcome desmoplasia and resistance in pancreatic ductal adenocarcinoma	88
Free fatty acid receptor-4 regulates T-cell-mediated allogeneic reaction through activating an aryl hydrocarbon receptor pathway	88
Five trends of China's pharmaceutical industry in 2022	87
GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer	87
Nanoparticle drug delivery system for the treatment of brain tumors: Breaching the blood–brain barrier	86
Editor Profiles: Guest Editors of Special Column on Hot Topic Reviews in Drug (II)	85
Aberrant astroglial Kir4.1 activation in the anterior cingulate cortex disrupts neuronal excitability and social behavior	85
Development of Chinese herbal medicine for sensorineural hearing loss	84
CarsiDock-Cov: A deep learning-guided approach for automated covalent docking and screening	83
Nanoparticles (NPs)-mediated lncBCMA silencing to promote eEF1A1 ubiquitination and suppress breast cancer growth and metastasis	83
Suppressing Wnt signaling of the blood‒tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases	83

Insights into therapeutic peptides in the cancer-immunity cycle: Update and challenges	81
The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation	81
Orally delivered exosome-like nanoparticles from Tetrastigma hemsleyanum Diels et Gilg remodel the gut–tumor immune axis to activate antitumor immunity	81
Unlocking T cell exhaustion: Insights and implications for CAR-T cell therapy	80
High-throughput ligand discovery in living cells using the cellular protein stability enhancement assay	80
Organoids, organ-on-a-chip, and microtumors: Biomimetic 3D tumor models advancing drug development and precision medicine	80