OOIR: Observatory of International Research

Papers

(The TQCC of Cellular Oncology is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Angiogenesis as a hallmark of solid tumors - clinical perspectives	135
Downregulated exosomal microRNA-148b-3p in cancer associated fibroblasts enhance chemosensitivity of bladder cancer cells by downregulating the Wnt/β-catenin pathway and upregulating PTEN	77
The tumor microenvironment as driver of stemness and therapeutic resistance in breast cancer: New challenges and therapeutic opportunities	76
The role of tumor-associated macrophages in osteosarcoma progression – therapeutic implications	53
Porphyromonas gingivalis promotes tumor progression in esophageal squamous cell carcinoma	51
A comprehensive review of SHP2 and its role in cancer	50
CAR T cell therapy as a promising approach in cancer immunotherapy: challenges and opportunities	41
MT1JP-mediated miR-24-3p/BCL2L2 axis promotes Lenvatinib resistance in hepatocellular carcinoma cells by inhibiting apoptosis	39
HDAC6: A unique HDAC family member as a cancer target	37
Immunosuppression, immune escape, and immunotherapy in pancreatic cancer: focused on the tumor microenvironment	37
Upregulation of TTYH3 promotes epithelial-to-mesenchymal transition through Wnt/β-catenin signaling and inhibits apoptosis in cholangiocarcinoma	34
Complement factor B regulates cellular senescence and is associated with poor prognosis in pancreatic cancer	30
Prognostic role of proliferating CD8+ cytotoxic Tcells in human cancers	30
Terminal α2,6-sialylation of epidermal growth factor receptor modulates antibody therapy response of colorectal cancer cells	28
Protein arginine methyltransferase 5: a potential cancer therapeutic target	28
A comprehensive prognostic signature for glioblastoma patients based on transcriptomics and single cell sequencing	28
How VEGF-A and its splice variants affect breast cancer development – clinical implications	28
Histone deacetylase (HDAC) 9: versatile biological functions and emerging roles in human cancer	27
YAP promotes sorafenib resistance in hepatocellular carcinoma by upregulating survivin	27
Roles for macrophage-polarizing interleukins in cancer immunity and immunotherapy	26
The Duchenne muscular dystrophy gene and cancer	26
Clinical perspectives of BET inhibition in ovarian cancer	26
Tweaking EMT and MDR dynamics to constrain triple-negative breast cancer invasiveness by EGFR and Wnt/β-catenin signaling regulation	24
Loss of ARID1A expression promotes lung adenocarcinoma metastasis and predicts a poor prognosis	23
Comprehending the crosstalk between Notch, Wnt and Hedgehog signaling pathways in oral squamous cell carcinoma - clinical implications	23

OrBITS: label-free and time-lapse monitoring of patient derived organoids for advanced drug screening	22
Cancer‐associated fibroblasts secrete hypoxia‐induced serglycin to promote head and neck squamous cell carcinoma tumor cell growth in vitro and in vivo by activating the Wnt/β-catenin pathway	22
Role of TGF-β in pancreatic ductal adenocarcinoma progression and PD-L1 expression	21
The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models	20
Hypoxia-induced ROS promotes mitochondrial fission and cisplatin chemosensitivity via HIF-1α/Mff regulation in head and neck squamous cell carcinoma	20
Exosomes: a potential diagnostic and treatment modality in the quest for counteracting cancer	19
LINC02154 promotes the proliferation and metastasis of hepatocellular carcinoma by enhancing SPC24 promoter activity and activating the PI3K-AKT signaling pathway	19
3-Phosphoglycerate dehydrogenase: a potential target for cancer treatment	19
Heterogeneity, inherent and acquired drug resistance in patient-derived organoid models of primary liver cancer	18
RETRACTED ARTICLE: IFIT1 modulates the proliferation, migration and invasion of pancreatic cancer cells via Wnt/β-catenin signaling	18
Combined inhibition of AURKA and HSF1 suppresses proliferation and promotes apoptosis in hepatocellular carcinoma by activating endoplasmic reticulum stress	18
Alterations in mucosa-associated microbiota in the stomach of patients with gastric cancer	18
Cholesterol homeostasis and cancer: a new perspective on the low-density lipoprotein receptor	17
Immunotherapy for pancreatic cancer: chasing the light at the end of the tunnel	17
The impact of mitochondria on cancer treatment resistance	17
Survivin drives tumor-associated macrophage reprogramming: a novel mechanism with potential impact for obesity	17
IRAK2-NF-κB signaling promotes glycolysis-dependent tumor growth in pancreatic cancer	17
Long non‐coding RNA LINC01137 contributes to oral squamous cell carcinoma development and is negatively regulated by miR-22-3p	17
Comprehensive analysis of cytoskeleton regulatory genes identifies ezrin as a prognostic marker and molecular target in acute myeloid leukemia	16
Bile acids increase intestinal marker expression via the FXR/SNAI2/miR-1 axis in the stomach	16
Beyond metabolic waste: lysine lactylation and its potential roles in cancer progression and cell fate determination	15
SIRT7 interacts with TEK (TIE2) to promote adriamycin induced metastasis in breast cancer	15
The role of pyroptosis in hepatocellular carcinoma	15
In silico transcriptomic mapping of integrins and immune activation in Basal-like and HER2+ breast cancer	15
Organoid technology for personalized pancreatic cancer therapy	15
Glutaminolysis is a metabolic route essential for survival and growth of prostate cancer cells and a target of 5α-dihydrotestosterone regulation	15
Bioactive peptide inhibits acute myeloid leukemia cell proliferation by downregulating ALKBH5-mediated m6A demethylation of EIF4EBP1 and MLST8 mRNA	14
The application of patient-derived organoid in the research of lung cancer	14
SPOCK1 promotes metastasis in pancreatic cancer via NF-κB-dependent epithelial-mesenchymal transition by interacting with IκB-α	14
UBE2S activates NF-κB signaling by binding with IκBα and promotes metastasis of lung adenocarcinoma cells	14
Discoidin domain receptor 1 promotes hepatocellular carcinoma progression through modulation of SLC1A5 and the mTORC1 signaling pathway	14
Crosstalk between long noncoding RNA and microRNA in Cancer	13
Rabeprazole has efficacy per se and reduces resistance to temozolomide in glioma via EMT inhibition	13
Aberrant N-glycosylation in cancer: MGAT5 and β1,6-GlcNAc branched N-glycans as critical regulators of tumor development and progression	12
DNA damage repair in glioblastoma: current perspectives on its role in tumour progression, treatment resistance and PIKKing potential therapeutic targets	12
Crosstalk between oxidative phosphorylation and immune escape in cancer: a new concept of therapeutic targets selection	12
Hypoxia-inducible miR-196a modulates glioblastoma cell proliferation and migration through complex regulation of NRAS	12
In-depth quantitative proteomics analysis revealed C1GALT1 depletion in ECC-1 cells mimics an aggressive endometrial cancer phenotype observed in cancer patients with low C1GALT1 expression	12
Blocking MMP-12-modulated epithelial-mesenchymal transition by repurposing penfluridol restrains lung adenocarcinoma metastasis via uPA/uPAR/TGF-β/Akt pathway	12
Effect of infiltrating immune cells in tumor microenvironment on metastasis of hepatocellular carcinoma	12
FBXO32 targets PHPT1 for ubiquitination to regulate the growth of EGFR mutant lung cancer	12
Molecular mechanisms underlying the action of carcinogens in gastric cancer with a glimpse into targeted therapy	12
IDH2, a novel target of OGT, facilitates glucose uptake and cellular bioenergy production via NF-κB signaling to promote colorectal cancer progression	12
Multifunctional thiosemicarbazones targeting sigma receptors: in vitro and in vivo antitumor activities in pancreatic cancer models	12
AZD4547 targets the FGFR/Akt/SOX2 axis to overcome paclitaxel resistance in head and neck cancer	12
Modulation of miR-146b by N6-methyladenosine modification remodels tumor-associated macrophages and enhances anti-PD-1 therapy in colorectal cancer	11
GAS41 mediates proliferation and GEM chemoresistance via H2A.Z.2 and Notch1 in pancreatic cancer	11
PD-1 and PD-L2 expression predict relapse risk and poor survival in patients with stage III colorectal cancer	11
BCL6 and the Notch pathway: a signaling axis leading to a novel druggable biotarget in triple negative breast cancer	11
Distinct tumor microenvironment landscapes of rectal cancer for prognosis and prediction of immunotherapy response	10

Perineural invasion in colorectal cancer: mechanisms of action and clinical relevance	10
Transglutaminases are oncogenic biomarkers in human cancers and therapeutic targeting of TGM2 blocks chemoresistance and macrophage infiltration in pancreatic cancer	10
Tumour-derived exosomal lncRNA SNHG16 induces telocytes to promote metastasis of hepatocellular carcinoma via the miR-942-3p/MMP9 axis	10
Expression of NOTCH1, NOTCH4, HLA-DMA and HLA-DRA is synergistically associated with T cell exclusion, immune checkpoint blockade efficacy and recurrence risk in ER-negative breast cancer	10
Soluble TGFBI aggravates the malignancy of cholangiocarcinoma through activation of the ITGB1 dependent PPARγ signalling pathway	10
The role of tumor-platelet interplay and micro tumor thrombi during hematogenous tumor metastasis	10
Integrin α6 overexpression promotes lymphangiogenesis and lymphatic metastasis via activating the NF-κB signaling pathway in lung adenocarcinoma	10
Role of ELMO1 in inflammation and cancer—clinical implications	10
Cystatin F acts as a mediator of immune suppression in glioblastoma	10
Acetylation-stabilized chloride intracellular channel 1 exerts a tumor-promoting effect on cervical cancer cells by activating NF-κB	10
YKL-40 protein expression in human tumor samples and human tumor cell line xenografts: implications for its use in tumor models	10
Vimentin promotes glioma progression and maintains glioma cell resistance to oxidative phosphorylation inhibition	9
Alteration and dysfunction of ion channels/transporters in a hypoxic microenvironment results in the development and progression of gastric cancer	9
H3K27 acetylation activated long noncoding RNA RP11-162G10.5 promotes breast cancer progression via the YBX1/GLO1 axis	9
Atypical cyclin P regulates cancer cell stemness through activation of the WNT pathway	9
The Breast Cancer Single-Cell Atlas: Defining cellular heterogeneity within model cell lines and primary tumors to inform disease subtype, stemness, and treatment options	9
Involvement of ACACA (acetyl-CoA carboxylase α) in the lung pre-metastatic niche formation in breast cancer by senescence phenotypic conversion in fibroblasts	9
MAOA suppresses the growth of gastric cancer by interacting with NDRG1 and regulating the Warburg effect through the PI3K/AKT/mTOR pathway	9
Epigenetic modulation of ferroptosis in cancer: Identifying epigenetic targets for novel anticancer therapy	9
Differential regulation of autophagy by STAU1 in alveolar rhabdomyosarcoma and non‐transformed skeletal muscle cells	9
Spheroid-induced heterogeneity and plasticity of uveal melanoma cells	9
Single-cell RNA profiling identifies diverse cellular responses to EWSR1/FLI1 downregulation in Ewing sarcoma cells	9
The ATO/miRNA-885-5p/MTPN axis induces reversal of drug-resistance in cholangiocarcinoma	9
Contribution of mechanical homeostasis to epithelial-mesenchymal transition	9
AKR1C3 is a biomarker and druggable target for oropharyngeal tumors	9
Loss of USP28 and SPINT2 expression promotes cancer cell survival after whole genome doubling	9
Hippocalcin-like 1 is a key regulator of LDHA activation that promotes the growth of non-small cell lung carcinoma	9
Glioblastoma, from disease understanding towards optimal cell-based in vitro models	8
MCT4 as a potential therapeutic target to augment gemcitabine chemosensitivity in resected pancreatic cancer	8
Digoxin treatment reactivates in vivo radioactive iodide uptake and correlates with favorable clinical outcome in non‐medullary thyroid cancer	8
Iron metabolism in colorectal cancer: a balancing act	8
Tumor-associated macrophage-derived GDNF promotes gastric cancer liver metastasis via a GFRA1-modulated autophagy flux	8
FSCN1 induced PTPRF-dependent tumor microenvironment inflammatory reprogramming promotes lung adenocarcinoma progression via regulating macrophagic glycolysis	8
Mild chronic hypoxia-induced HIF-2α interacts with c-MYC through competition with HIF-1α to induce hepatocellular carcinoma cell proliferation	8
Application of circulating tumour cells to predict response to treatment in head and neck cancer	8
Recombinant adenovirus expressing the fusion protein PD1PVR improves CD8+ T cell-mediated antitumor efficacy with long-term tumor-specific immune surveillance in hepatocellular carcinoma	8
The LINC00152/miR-205-5p/CXCL11 axis in hepatocellular carcinoma cancer-associated fibroblasts affects cancer cell phenotypes and tumor growth	8
RNA sequencing and functional studies of patient-derived cells reveal that neurexin-1 and regulators of this pathway are associated with poor outcomes in Ewing sarcoma	8
PD-1-CD28 fusion protein strengthens mesothelin-specific TRuC T cells in preclinical solid tumor models	8
The ceramide synthase (CERS/LASS) family: Functions involved in cancer progression	8
FUT8 is regulated by miR‐122‐5p and promotes malignancies in intrahepatic cholangiocarcinoma via PI3K/AKT signaling	8
PAK3 is a key signature gene of the glioma proneural subtype and affects its proliferation, differentiation and growth	8
EV-miRome-wide profiling uncovers miR-320c for detecting metastatic colorectal cancer and monitoring the therapeutic response	8
ACSM3 suppresses the pathogenesis of high-grade serous ovarian carcinoma via promoting AMPK activity	8
Clostridium butyricum and its metabolite butyrate promote ferroptosis susceptibility in pancreatic ductal adenocarcinoma	8