Cellular Oncology

Article	Citations
Angiogenesis as a hallmark of solid tumors - clinical perspectives	103
Oxaliplatin induces immunogenic cell death in hepatocellular carcinoma cells and synergizes with immune checkpoint blockade therapy	71
The tumor microenvironment as driver of stemness and therapeutic resistance in breast cancer: New challenges and therapeutic opportunities	70
Downregulated exosomal microRNA-148b-3p in cancer associated fibroblasts enhance chemosensitivity of bladder cancer cells by downregulating the Wnt/β-catenin pathway and upregulating PTEN	63
The role of ErbB4 in cancer	63
Current insights into the metastasis of epithelial ovarian cancer - hopes and hurdles	63
PFKP is highly expressed in lung cancer and regulates glucose metabolism	56
DNMT1 as a therapeutic target in pancreatic cancer: mechanisms and clinical implications	52
Role of CK2 inhibitor CX-4945 in anti-cancer combination therapy – potential clinical relevance	47
The role of tumor-associated macrophages in osteosarcoma progression – therapeutic implications	44
Pharmacogenomics of 5-fluorouracil in colorectal cancer: review and update	42
Porphyromonas gingivalis promotes tumor progression in esophageal squamous cell carcinoma	41
Macrophage-secreted MMP9 induces mesenchymal transition in pancreatic cancer cells via PAR1 activation	40
CircRNA BIRC6 promotes non-small cell lung cancer cell progression by sponging microRNA-145	38
CXCL-10: a new candidate for melanoma therapy?	35
MT1JP-mediated miR-24-3p/BCL2L2 axis promotes Lenvatinib resistance in hepatocellular carcinoma cells by inhibiting apoptosis	32
A comprehensive review of SHP2 and its role in cancer	31
Dp44mT, an iron chelator, suppresses growth and induces apoptosis via RORA-mediated NDRG2-IL6/JAK2/STAT3 signaling in glioma	31
CAR T cell therapy as a promising approach in cancer immunotherapy: challenges and opportunities	30
Aurora A kinase and its activator TPX2 are potential therapeutic targets in KRAS-induced pancreatic cancer	27
Immunosuppression, immune escape, and immunotherapy in pancreatic cancer: focused on the tumor microenvironment	27
Prognostic role of proliferating CD8+ cytotoxic Tcells in human cancers	27
Upregulation of TTYH3 promotes epithelial-to-mesenchymal transition through Wnt/β-catenin signaling and inhibits apoptosis in cholangiocarcinoma	26
[10]-Gingerol improves doxorubicin anticancer activity and decreases its side effects in triple negative breast cancer models	26
HIF1A expression correlates with increased tumor immune and stromal signatures and aggressive phenotypes in human cancers	25

Complement factor B regulates cellular senescence and is associated with poor prognosis in pancreatic cancer	25
IL-17A and IL-17F orchestrate macrophages to promote lung cancer	25
Non-coding RNAs underlying chemoresistance in gastric cancer	25
HDAC6: A unique HDAC family member as a cancer target	24
Functional and metabolic targeting of natural killer cells to solid tumors	24
Protein arginine methyltransferase 5: a potential cancer therapeutic target	24
LncRNA PVT1 induces aggressive vasculogenic mimicry formation through activating the STAT3/Slug axis and epithelial-to-mesenchymal transition in gastric cancer	23
EBV-miR-BART10-3p and EBV-miR-BART22 promote metastasis of EBV-associated gastric carcinoma by activating the canonical Wnt signaling pathway	23
Tweaking EMT and MDR dynamics to constrain triple-negative breast cancer invasiveness by EGFR and Wnt/β-catenin signaling regulation	22
YAP promotes sorafenib resistance in hepatocellular carcinoma by upregulating survivin	22
Circular RNA circNFATC3 acts as a miR-9-5p sponge to promote cervical cancer development by upregulating SDC2	22
Mitoxantrone triggers immunogenic prostate cancer cell death via p53-dependent PERK expression	22
Clinical perspectives of BET inhibition in ovarian cancer	22
The hedgehog pathway regulates cancer stem cells in serous adenocarcinoma of the ovary	21
Prevalence of CD8+ cytotoxic lymphocytes in human neoplasms	21
The Duchenne muscular dystrophy gene and cancer	21
A comprehensive prognostic signature for glioblastoma patients based on transcriptomics and single cell sequencing	21
Terminal α2,6-sialylation of epidermal growth factor receptor modulates antibody therapy response of colorectal cancer cells	21
Roles for macrophage-polarizing interleukins in cancer immunity and immunotherapy	20
Noncoding RNAs in oral premalignant disorders and oral squamous cell carcinoma	19
Cancer‐associated fibroblasts secrete hypoxia‐induced serglycin to promote head and neck squamous cell carcinoma tumor cell growth in vitro and in vivo by activating the Wnt/β-catenin pathway	19
Co-expression analysis of pancreatic cancer proteome reveals biology and prognostic biomarkers	19
Hypoxia-induced ROS promotes mitochondrial fission and cisplatin chemosensitivity via HIF-1α/Mff regulation in head and neck squamous cell carcinoma	18
Bufalin inhibits hepatitis B virus-associated hepatocellular carcinoma development through androgen receptor dephosphorylation and cell cycle-related kinase degradation	18
Enhanced immunogenicity of leukemia-derived exosomes via transfection with lentiviral vectors encoding costimulatory molecules	18
Molecular mechanisms underlining the role of metformin as a therapeutic agent in lung cancer	17
RETRACTED ARTICLE: Long non-coding RNA SNHG3, induced by IL-6/STAT3 transactivation, promotes stem cell-like properties of gastric cancer cells by regulating the miR-3619-5p/ARL2 axis	17
Activation of dopamine receptor D1 inhibits glioblastoma tumorigenicity by regulating autophagic activity	17
A lectin-based glycomic approach identifies FUT8 as a driver of radioresistance in oesophageal squamous cell carcinoma	17
Insulinoma-associated protein 1 (INSM1): a potential biomarker and therapeutic target for neuroendocrine tumors	17
Loss of ARID1A expression promotes lung adenocarcinoma metastasis and predicts a poor prognosis	17
Comprehending the crosstalk between Notch, Wnt and Hedgehog signaling pathways in oral squamous cell carcinoma - clinical implications	17
Long noncoding RNA LINC01234 silencing exerts an anti-oncogenic effect in esophageal cancer cells through microRNA-193a-5p-mediated CCNE1 downregulation	17
The PI3K/mTOR dual inhibitor GSK458 potently impedes ovarian cancer tumorigenesis and metastasis	16
How VEGF-A and its splice variants affect breast cancer development – clinical implications	16
WNT1, a target of miR-34a, promotes cervical squamous cell carcinoma proliferation and invasion by induction of an E-P cadherin switch via the WNT/β-catenin pathway	16
Role of TGF-β in pancreatic ductal adenocarcinoma progression and PD-L1 expression	16
Circular RNA circCSNK1G3 induces HOXA10 signaling and promotes the growth and metastasis of lung adenocarcinoma cells through hsa-miR-143-3p sponging	16
LINC01419 promotes cell proliferation and metastasis in hepatocellular carcinoma by enhancing NDRG1 promoter activity	16
Long non‐coding RNA LINC01137 contributes to oral squamous cell carcinoma development and is negatively regulated by miR-22-3p	16
Association of Jagged1 expression with malignancy and prognosis in human pancreatic cancer	15
The impact of mitochondria on cancer treatment resistance	15
Sp1-mediated up-regulation of lnc00152 promotes invasion and metastasis of retinoblastoma cells via the miR-30d/SOX9/ZEB2 pathway	15
SIRT7 interacts with TEK (TIE2) to promote adriamycin induced metastasis in breast cancer	15
3-Phosphoglycerate dehydrogenase: a potential target for cancer treatment	15
LINC02154 promotes the proliferation and metastasis of hepatocellular carcinoma by enhancing SPC24 promoter activity and activating the PI3K-AKT signaling pathway	15
Immunotherapy for pancreatic cancer: chasing the light at the end of the tunnel	15
Survivin drives tumor-associated macrophage reprogramming: a novel mechanism with potential impact for obesity	15
Comprehensive analysis of cytoskeleton regulatory genes identifies ezrin as a prognostic marker and molecular target in acute myeloid leukemia	15
Ubiquitin-specific protease 2a promotes hepatocellular carcinoma progression via deubiquitination and stabilization of RAB1A	15

Raloxifene inhibits pancreatic adenocarcinoma growth by interfering with ERβ and IL-6/gp130/STAT3 signaling	15
RETRACTED ARTICLE: IFIT1 modulates the proliferation, migration and invasion of pancreatic cancer cells via Wnt/β-catenin signaling	15
Epithelial-stromal communication via CXCL1-CXCR2 interaction stimulates growth of ovarian cancer cells through p38 activation	14
RETRACTED ARTICLE: The POU2F1/miR-4490/USP22 axis regulates cell proliferation and metastasis in gastric cancer	14
Synergistic killing effect of paclitaxel and honokiol in non-small cell lung cancer cells through paraptosis induction	14
1p/19q co-deletion status is associated with distinct tumor-associated macrophage infiltration in IDH mutated lower-grade gliomas	14
Effect of EphA2 knockdown on melanoma metastasis depends on intrinsic ephrinA1 level	14
LncRNA ZNF503-AS1 acts as a tumor suppressor in bladder cancer by up-regulating Ca2+ concentration via transcription factor GATA6	14
Heterogeneity, inherent and acquired drug resistance in patient-derived organoid models of primary liver cancer	13
The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models	13
UBE2S activates NF-κB signaling by binding with IκBα and promotes metastasis of lung adenocarcinoma cells	13
Organoid technology for personalized pancreatic cancer therapy	13
Circular RNA circ-102,166 acts as a sponge of miR-182 and miR-184 to suppress hepatocellular carcinoma proliferation and invasion	13
Histone deacetylase (HDAC) 9: versatile biological functions and emerging roles in human cancer	13
Discoidin domain receptor 1 promotes hepatocellular carcinoma progression through modulation of SLC1A5 and the mTORC1 signaling pathway	13
Pervasive promoter hypermethylation of silenced TERT alleles in human cancers	13
In silico transcriptomic mapping of integrins and immune activation in Basal-like and HER2+ breast cancer	13
Bile acids increase intestinal marker expression via the FXR/SNAI2/miR-1 axis in the stomach	13
Pure high-grade papillary urothelial bladder cancer: a luminal-like subgroup with potential for targeted therapy	12
Rabeprazole has efficacy per se and reduces resistance to temozolomide in glioma via EMT inhibition	12
IRAK2-NF-κB signaling promotes glycolysis-dependent tumor growth in pancreatic cancer	12
SPOCK1 promotes metastasis in pancreatic cancer via NF-κB-dependent epithelial-mesenchymal transition by interacting with IκB-α	12
Alterations in mucosa-associated microbiota in the stomach of patients with gastric cancer	12
Bioactive peptide inhibits acute myeloid leukemia cell proliferation by downregulating ALKBH5-mediated m6A demethylation of EIF4EBP1 and MLST8 mRNA	11
Multifunctional thiosemicarbazones targeting sigma receptors: in vitro and in vivo antitumor activities in pancreatic cancer models	11
Downregulation of beta-catenin in chemo-tolerant TNBC through changes in receptor and antagonist profiles of the WNT pathway: Clinical and prognostic implications	11
Blocking MMP-12-modulated epithelial-mesenchymal transition by repurposing penfluridol restrains lung adenocarcinoma metastasis via uPA/uPAR/TGF-β/Akt pathway	11
OrBITS: label-free and time-lapse monitoring of patient derived organoids for advanced drug screening	11
Association of DCBLD2 upregulation with tumor progression and poor survival in colorectal cancer	11
Cholesterol homeostasis and cancer: a new perspective on the low-density lipoprotein receptor	11
Role of the bone microenvironment in bone metastasis of malignant tumors - therapeutic implications	11
DNA damage repair in glioblastoma: current perspectives on its role in tumour progression, treatment resistance and PIKKing potential therapeutic targets	10
Hypoxia-inducible miR-196a modulates glioblastoma cell proliferation and migration through complex regulation of NRAS	10
Identification of a stemness-related gene panel associated with BET inhibition in triple negative breast cancer	10
NF-κB-mediated miR-650 plays oncogenic roles and activates AKT/ERK/NF-κB pathways by targeting RERG in glioma cells	10
Combined inhibition of AURKA and HSF1 suppresses proliferation and promotes apoptosis in hepatocellular carcinoma by activating endoplasmic reticulum stress	10
Glutaminolysis is a metabolic route essential for survival and growth of prostate cancer cells and a target of 5α-dihydrotestosterone regulation	10
Tumour-derived exosomal lncRNA SNHG16 induces telocytes to promote metastasis of hepatocellular carcinoma via the miR-942-3p/MMP9 axis	9
BCL6 and the Notch pathway: a signaling axis leading to a novel druggable biotarget in triple negative breast cancer	9
Integrin α6 overexpression promotes lymphangiogenesis and lymphatic metastasis via activating the NF-κB signaling pathway in lung adenocarcinoma	9
Molecular mechanisms underlying the action of carcinogens in gastric cancer with a glimpse into targeted therapy	9
PD-1 and PD-L2 expression predict relapse risk and poor survival in patients with stage III colorectal cancer	9
Single-cell RNA profiling identifies diverse cellular responses to EWSR1/FLI1 downregulation in Ewing sarcoma cells	9
Exosomes: a potential diagnostic and treatment modality in the quest for counteracting cancer	9
AZD4547 targets the FGFR/Akt/SOX2 axis to overcome paclitaxel resistance in head and neck cancer	9
The ATO/miRNA-885-5p/MTPN axis induces reversal of drug-resistance in cholangiocarcinoma	9
Y-box binding protein 1 (YB-1) promotes gefitinib resistance in lung adenocarcinoma cells by activating AKT signaling and epithelial–mesenchymal transition through targeting major vault protein (MVP)	9
CD105 is a prognostic marker and valid endothelial target for microbubble platforms in cholangiocarcinoma	9
Aberrantly expressed Bruton’s tyrosine kinase preferentially drives metastatic and stem cell-like phenotypes in neuroblastoma cells	9
BRD4 modulates vulnerability of triple-negative breast cancer to targeting of integrin-dependent signaling pathways	9
The application of patient-derived organoid in the research of lung cancer	8
Atypical cyclin P regulates cancer cell stemness through activation of the WNT pathway	8
Loss of USP28 and SPINT2 expression promotes cancer cell survival after whole genome doubling	8
Glioblastoma, from disease understanding towards optimal cell-based in vitro models	8
Hippocalcin-like 1 is a key regulator of LDHA activation that promotes the growth of non-small cell lung carcinoma	8
Alteration and dysfunction of ion channels/transporters in a hypoxic microenvironment results in the development and progression of gastric cancer	8
Soluble TGFBI aggravates the malignancy of cholangiocarcinoma through activation of the ITGB1 dependent PPARγ signalling pathway	8
Cystatin F acts as a mediator of immune suppression in glioblastoma	8
Crosstalk between oxidative phosphorylation and immune escape in cancer: a new concept of therapeutic targets selection	8
Acetylation-stabilized chloride intracellular channel 1 exerts a tumor-promoting effect on cervical cancer cells by activating NF-κB	8
Mild chronic hypoxia-induced HIF-2α interacts with c-MYC through competition with HIF-1α to induce hepatocellular carcinoma cell proliferation	8
LINC00858 knockdown inhibits gastric cancer cell growth and induces apoptosis through reducing WNK2 promoter methylation	8
Distinct tumor microenvironment landscapes of rectal cancer for prognosis and prediction of immunotherapy response	8
Digoxin treatment reactivates in vivo radioactive iodide uptake and correlates with favorable clinical outcome in non‐medullary thyroid cancer	8
Beyond metabolic waste: lysine lactylation and its potential roles in cancer progression and cell fate determination	8
Effect of infiltrating immune cells in tumor microenvironment on metastasis of hepatocellular carcinoma	8
FBXO32 targets PHPT1 for ubiquitination to regulate the growth of EGFR mutant lung cancer	8
YKL-40 protein expression in human tumor samples and human tumor cell line xenografts: implications for its use in tumor models	8
The ceramide synthase (CERS/LASS) family: Functions involved in cancer progression	7
In-depth quantitative proteomics analysis revealed C1GALT1 depletion in ECC-1 cells mimics an aggressive endometrial cancer phenotype observed in cancer patients with low C1GALT1 expression	7
Contribution of mechanical homeostasis to epithelial-mesenchymal transition	7
AKR1C3 is a biomarker and druggable target for oropharyngeal tumors	7
ACSM3 suppresses the pathogenesis of high-grade serous ovarian carcinoma via promoting AMPK activity	7
Modeling of the immune response in the pathogenesis of solid tumors and its prognostic significance	7
Recombinant adenovirus expressing the fusion protein PD1PVR improves CD8+ T cell-mediated antitumor efficacy with long-term tumor-specific immune surveillance in hepatocellular carcinoma	7
The role of tumor-platelet interplay and micro tumor thrombi during hematogenous tumor metastasis	7
Selective capture of plasma cell-free tumor DNA on magnetic beads: a sensitive and versatile tool for liquid biopsy	7
MCT4 as a potential therapeutic target to augment gemcitabine chemosensitivity in resected pancreatic cancer	7
Effects of FGFR inhibitors TKI258, BGJ398 and AZD4547 on breast cancer cells in 2D, 3D and tissue explant cultures	7
Differential regulation of autophagy by STAU1 in alveolar rhabdomyosarcoma and non‐transformed skeletal muscle cells	7

PAK3 is a key signature gene of the glioma proneural subtype and affects its proliferation, differentiation and growth	6
GAS41 mediates proliferation and GEM chemoresistance via H2A.Z.2 and Notch1 in pancreatic cancer	6
CHRNA5 belongs to the secondary estrogen signaling network exhibiting prognostic significance in breast cancer	6
Reversine exerts cytotoxic effects through multiple cell death mechanisms in acute lymphoblastic leukemia	6
Nucleotide sugar transporter SLC35A2 is involved in promoting hepatocellular carcinoma metastasis by regulating cellular glycosylation	6
Selective targeting BMP2 and 4 in SMAD4 negative esophageal adenocarcinoma inhibits tumor growth and aggressiveness in preclinical models	6
Molecular changes in adipocyte-derived stem cells during their interplay with cervical cancer cells	6
PD-1-CD28 fusion protein strengthens mesothelin-specific TRuC T cells in preclinical solid tumor models	6
CDK7 blockade suppresses super‐enhancer‐associated oncogenes in bladder cancer	6
Role of ELMO1 in inflammation and cancer—clinical implications	6
Systematic profiling of immune signatures identifies prognostic predictors in lung adenocarcinoma	6
Transglutaminases are oncogenic biomarkers in human cancers and therapeutic targeting of TGM2 blocks chemoresistance and macrophage infiltration in pancreatic cancer	6
Galanin mediates tumor-induced immunosuppression in head and neck squamous cell carcinoma	6
FUT8 is regulated by miR‐122‐5p and promotes malignancies in intrahepatic cholangiocarcinoma via PI3K/AKT signaling	6
Involvement of ACACA (acetyl-CoA carboxylase α) in the lung pre-metastatic niche formation in breast cancer by senescence phenotypic conversion in fibroblasts	5
CEP55 3’-UTR promotes epithelial–mesenchymal transition and enhances tumorigenicity of bladder cancer cells by acting as a ceRNA regulating miR-497-5p	5
E3 ubiquitin ligases in cancer stem cells: key regulators of cancer hallmarks and novel therapeutic opportunities	5
MAOA suppresses the growth of gastric cancer by interacting with NDRG1 and regulating the Warburg effect through the PI3K/AKT/mTOR pathway	5
Calcium acts as a central player in melatonin antitumor activity in sarcoma cells	5
Enhanced migration of breast and lung cancer cells deficient for cN-II and CD73 via COX-2/PGE2/AKT axis regulation	5
Ascofuranone suppresses invasion and F-actin cytoskeleton organization in cancer cells by inhibiting the mTOR complex 1 signaling pathway	5
Spheroid-induced heterogeneity and plasticity of uveal melanoma cells	5
The Breast Cancer Single-Cell Atlas: Defining cellular heterogeneity within model cell lines and primary tumors to inform disease subtype, stemness, and treatment options	5
Immunotherapy and immunoengineering for breast cancer; a comprehensive insight into CAR-T cell therapy advancements, challenges and prospects	5
Applications and mechanisms of the cyclin-dependent kinase 4/6 inhibitor, PD-0332991, in solid tumors	5
The role of pyroptosis in hepatocellular carcinoma	5
EV-miRome-wide profiling uncovers miR-320c for detecting metastatic colorectal cancer and monitoring the therapeutic response	5
Cell signaling activation and extracellular matrix remodeling underpin glioma tumor microenvironment heterogeneity and organization	5
RNA sequencing and functional studies of patient-derived cells reveal that neurexin-1 and regulators of this pathway are associated with poor outcomes in Ewing sarcoma	5
Age-specific oncogenic pathways in head and neck squamous cell carcinoma - are elderly a different subcategory?	5
Single cell profiling of γδ hepatosplenic T-cell lymphoma unravels tumor cell heterogeneity associated with disease progression	5
Increased SPRY1 expression activates NF-κB signaling and promotes pancreatic cancer progression by recruiting neutrophils and macrophages through CXCL12-CXCR4 axis	5
IDH2, a novel target of OGT, facilitates glucose uptake and cellular bioenergy production via NF-κB signaling to promote colorectal cancer progression	5
Expression of NOTCH1, NOTCH4, HLA-DMA and HLA-DRA is synergistically associated with T cell exclusion, immune checkpoint blockade efficacy and recurrence risk in ER-negative breast cancer	5
Salivary microRNAs identified by small RNA sequencing as potential predictors of response to intensity-modulated radiotherapy in head and neck cancer patients	5
Crosstalk between long noncoding RNA and microRNA in Cancer	5
Overexpression of Sal-like protein 4 in head and neck cancer: epigenetic effects and clinical correlations	5
Chronic exercise training attenuates prostate cancer-induced molecular remodelling in the testis	5
Low-dose anti-VEGFR2 therapy promotes anti-tumor immunity in lung adenocarcinoma by down-regulating the expression of layilin on tumor-infiltrating CD8+T cells	4
SLC26A9 deficiency causes gastric intraepithelial neoplasia in mice and aggressive gastric cancer in humans	4
Deciphering molecular mechanisms of metastasis: novel insights into targets and therapeutics	4
FSCN1 induced PTPRF-dependent tumor microenvironment inflammatory reprogramming promotes lung adenocarcinoma progression via regulating macrophagic glycolysis	4
Application of circulating tumour cells to predict response to treatment in head and neck cancer	4
PKP1 and MYC create a feedforward loop linking transcription and translation in squamous cell lung cancer	4
PAQR5 inhibits the growth and metastasis of clear cell renal cell carcinoma by suppressing the JAK/STAT3 signaling pathway	4
The changing microRNA landscape by color and cloudiness: a cautionary tale for nipple aspirate fluid biomarker analysis	4
Drug combination screening as a translational approach toward an improved drug therapy for chordoma	4
Telomerase-targeting compounds Imetelstat and 6-thio-dG act synergistically with chemotherapy in high-risk neuroblastoma models	4
YAP1 acts as a negative regulator of pro-tumor TAZ expression in esophageal squamous cell carcinoma	4
TNFR2 antagonistic antibody induces the death of tumor infiltrating CD4+Foxp3+ regulatory T cells	4
Dual contribution of the mTOR pathway and of the metabolism of amino acids in prostate cancer	4
Novel preclinical gastroenteropancreatic neuroendocrine neoplasia models demonstrate the feasibility of mutation-based targeted therapy	4
Direct knockdown of phospho-PTM targets mediated by TRIM21 can improve personalized treatment in breast cancer	4
Iron metabolism in colorectal cancer: a balancing act	4
Combination of RSK inhibitor LJH-685 and FLT3 inhibitor FF-10101 promoted apoptosis and proliferation inhibition of AML cell lines	4
Modulation of miR-146b by N6-methyladenosine modification remodels tumor-associated macrophages and enhances anti-PD-1 therapy in colorectal cancer	4
Zebularine-induced myeloma cell death is accompanied by decreased c-Myc expression	4
In vivo study revealed pro-tumorigenic effect of CMTM3 in hepatocellular carcinoma involving the regulation of peroxisome proliferator-activated receptor gamma (PPARγ)	4
Methionine-producing tumor micro(be) environment fuels growth of solid tumors	4
Identification of lysosome‐targeting drugs with anti‐inflammatory activity as potential invasion inhibitors of treatment resistant HER2 positive cancers	4
Targeting tumor-intrinsic PD-L1 suppresses the progression and aggressiveness of head and neck cancer by inhibiting GSK3β-dependent Snail degradation	4
Perineural invasion in colorectal cancer: mechanisms of action and clinical relevance	4