OOIR: Observatory of International Research

Papers

(The median citation count of International Journal for Parasitology-Drugs and Drug Resistance is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Combining the zebrafish embryo developmental toxicity assay (ZEDTA) with hemoglobin staining to accelerate the research of novel antimalarial drugs for pregnant women	78
Antiamoeboid activity of squamins C–F, cyclooctapeptides from Annona globifora	73
Chicory (Cichorium intybus) reduces cyathostomin egg excretion and larval development in grazing horses	67
Screening of the activity of sixty essential oils against plasmodium early mosquito stages in vitro and machine learning analysis reveals new putative inhibitors of malaria parasites	63
Effects of the G-quadruplex-binding drugs quarfloxin and CX-5461 on the malaria parasite Plasmodium falciparum	58
Pharmacokinetic and pharmacodynamic considerations for treating sarcoptic mange with cross-relevance to Australian wildlife	52
Development of a three-colour digital PCR for early and quantitative detection of benzimidazole resistance-associated single nucleotide polymorphisms in Haemonchus contortus	50
Lumefantrine attenuates Plasmodium falciparum artemisinin resistance during the early ring stage	46
Efficacy of fenbendazole against gastrointestinal nematodes in naturally infected goats in Maputo Province, Mozambique using in vivo, in vitro and molecular assessment	37
MEFAS, a hybrid of artesunate-mefloquine active against asexual stages of Plasmodium vivax in field isolates, inhibits malaria transmission	33
Nourseothricin as a novel drug for selection of transgenic Giardia lamblia	30
In vitro evaluation of new 4-thiazolidinones on invasion and growth of Toxoplasma gondii	25
Modified dosing schedule efficacy of fosmidomycin and clindamycin against murine malaria Plasmodium berghei	22
Discovery of antiplasmodial pyridine carboxamides and thiocarboxamides	22
Plasmodium RNA triphosphatase validation as antimalarial target	22
Plasmodium falciparum resistance to ACTs: Emergence, mechanisms, and outlook	22
Acaricide resistance status of livestock ticks from East and West Africa and in vivo efficacy of acaricides to control them	21
The phosphatase inhibitor BVT-948 can be used to efficiently screen functional sexual development proteins in the malaria parasite Plasmodium berghei	21
Suramin action in African trypanosomes involves a RuvB-like DNA helicase	21
A review study on the anti-trichomonas activities of medicinal plants	20
Current and emerging target identification methods for novel antimalarials	18
Phenotypic and genotypic characterization of acaricide resistance in Rhipicephalus microplus field isolates from South Africa and Brazil	18
Antiplasmodial activity of the natural product compounds alstonine and himbeline	17
Monepantel pharmaco-therapeutic evaluation in cattle: Pattern of efficacy against multidrug resistant nematodes	17
Phenotypic and genotypic analysis of benzimidazole resistance in reciprocal genetic crosses of Haemonchus contortus	17

Exploring the β-tubulin gene family in a benzimidazole-resistant Parascaris univalens population	17
In vivo efficiency of praziquantel treatment of single-sex Schistosoma japonicum aged three months old in mice	16
Emergence of Ancylostoma caninum parasites with the benzimidazole resistance F167Y polymorphism in the US dog population	16
Repurposing DrugBank compounds as potential Plasmodium falciparum class 1a aminoacyl tRNA synthetase multi-stage pan-inhibitors with a specific focus on mitomycin	16
Reflecting on the past and fast forwarding to present day anthelmintic resistant Ancylostoma caninum–A critical issue we neglected to forecast	16
Comparative structure activity and target exploration of 1,2-diphenylethynes in Haemonchus contortus and Caenorhabditis elegans	16
Natural marine products as antiprotozoal agents against amitochondrial parasites	15
Recent in vitro advances in the ocular antimicrobial agents against Acanthamoeba	14
Rational approach to drug discovery for human schistosomiasis	13
In vitro validation of the amoebicidal activity of commercial eye drops as second activity	13
Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization	13
Stepwise in vitro screening of MMV pathogen box compounds against Plasmodium falciparum to identify potent antimalarial candidates	13
Genetic surveillance for monitoring the impact of drug use on Plasmodium falciparum populations	13
Genetic diversity in the metronidazole metabolism genes nitroreductases and pyruvate ferredoxin oxidoreductases in susceptible and refractory clinical samples of Giardia lamblia	13
In vitro and in vivo activity evaluation and mode of action of broxaldine on Toxoplasma gondii	12
Proteomic characterization of Toxoplasma gondii ME49 derived strains resistant to the artemisinin derivatives artemiside and artemisone implies potential mode of action independent of ROS formation	11
Dissection of haplotype-specific drug response phenotypes in multiclonal malaria isolates	11
Characterization of a P-glycoprotein drug transporter from Toxocara canis with a novel pharmacological profile	11
In vitro amoebicidal effects of arabinogalactan-based ophthalmic solution	11
Evaluation of the antiplasmodial efficacy of synthetic 2,5-diphenyloxazole analogs of compounds naturally derived from Oxytropis lanata	10
Efficacy of the treatment using a microemulsion loaded with epoxy-α-lapachone in combination with meglumine antimoniate against murine infection by Leishmania (Leishmania) amazonensis	10
In vitro and in vivo activities of a trithiolato-diRuthenium complex conjugated with sulfadoxine against the apicomplexan parasite Toxoplasma gondii	10
Acrylonitrile derivatives: In vitro activity and mechanism of cell death induction against Trypanosoma cruzi and Leishmania amazonensis	10
In artemisinin-resistant falciparum malaria parasites, mitochondrial metabolic pathways are essential for survival but not those of apicoplast	10
Comparison of electrophysiological and motility assays to study anthelmintic effects in Caenorhabditis elegans	9
Lactoferrin-modified nanoemulsions enhance brain-targeting and therapeutic efficacy of arctigenin against Toxoplasma gondii-induced neuronal injury	9
Diethylcarbamazine mediated potentiation of emodepside induced paralysis requires TRP-2 in adult Brugia malayi	9
Using droplet digital PCR for the detection of hco-acr-8b levamisole resistance marker in H. contortus	9
Integration of population and functional genomics to understand mechanisms of artemisinin resistance in Plasmodium falciparum	9
Egg reappearance periods of anthelmintics against equine cyathostomins: The state of play revisited	8
Corrigendum to “Efficacy of flukicides against Fasciola hepatica and first report of triclabendazole resistance on German sheep farms” [Int. J. Parasitol. Drugs Drug Resist. 23 (2023) 94–105]	8
Erratum to “Uncovering the antimalarial potential of toad venoms through a bioassay-guided fractionation process” [Int. J. Parasitol.: Drugs Drug Resist. 20 (2022) 97–107]	8
Benzimidazole F167Y polymorphism in the canine hookworm, Ancylostoma caninum: Widespread geographic, seasonal, age, and breed distribution in United States and Canada dogs	8
Anthelmintic resistance in equine nematodes: Current status and emerging trends	7
The presence and relative frequency detection of the levamisole-resistance-associated S168T substitution in hco-acr-8 in Haemonchus contortus	7
A graphical user interface for wrmXpress 2.0 streamlines helminth phenotypic screening	7
Allele specific PCR for a major marker of levamisole resistance in Haemonchus contortus	7
Investigation of the threonine metabolism of Echinococcus multilocularis: The threonine dehydrogenase as a potential drug target in alveolar echinococcosis	7
Primaquine for Plasmodium vivax radical cure: What we do not know and why it matters	7
Thiophene derivatives activity against the protozoan parasite Leishmania infantum	7
Demonstration of reduced efficacy against cyathostomins without change in species composition after pyrantel embonate treatment in Swedish equine establishments	6
Deep-amplicon sequencing of the complete beta-tubulin gene in Trichuris trichiura before and after albendazole treatment	6
Forward genetic analysis of monensin and diclazuril resistance in Eimeria tenella	6
Heartworm disease – Overview, intervention, and industry perspective	6
Fighting Plasmodium chloroquine resistance with acetylenic chloroquine analogues	6
Evaluation of the in vitro susceptibility of various filarial nematodes to emodepside	6
Profile of molecular markers of Sulfadoxine-Pyrimethamine-resistant Plasmodium falciparum in individuals living in southern area of Brazzaville, Republic of Congo	6
Antileishmanial and synergic effects of Rhanterium epapposum essential oil and its main compounds alone and combined with glucantime against Leishmania major infection	5
Investigation of risk factors associated with Ancylostoma spp. infection and the benzimidazole F167Y resistance marker polymorphism in dogs from the United States	5
Selenosugars targeting the infective stage of Trypanosoma brucei with high selectivity	5

Revisiting anthelmintic resistance in sheep flocks from São Paulo State, Brazil	5
Phylogenetic and transcriptomic study of aldo-keto reductases in Haemonchus contortus and their inducibility by flubendazole	5
Genetic characterisation of the Theileria annulata cytochrome b locus and its impact on buparvaquone resistance in bovine	5
Thieno[3,2-b]pyrrole 5-carboxamides as potent and selective inhibitors of Giardia duodenalis	5
Droplet digital PCR as a tool to detect resistant isolates of Dirofilaria immitis	5
Modified peptides and organic metabolites of cyanobacterial origin with antiplasmodial properties	5
In vitro evaluation of Resveratrol as a potential pre-exposure prophylactic drug against Trypanosoma cruzi infection	5
The molecular basis of antimalarial drug resistance in Plasmodium vivax	5
In vitro activity, safety and in vivo efficacy of the novel bumped kinase inhibitor BKI-1748 in non-pregnant and pregnant mice experimentally infected with Neospora caninum tachyzoites and Toxoplasma	5
Repurposing in vitro approaches for screening anti-parasitic drugs against the brain-eating amoeba Naegleria fowleri	5
Identification of compounds responsible for the anthelmintic effects of chicory (Cichorium intybus) by molecular networking and bio-guided fractionation	4
Absence of association between Pfnfs1 mutation and in vitro susceptibility to lumefantrine in Plasmodium falciparum	4
Uncovering the antimalarial potential of toad venoms through a bioassay-guided fractionation process	4
Molecular characterization and analysis of the ATPase ASNA1 homolog gene of Eimeria tenella in a drug sensitive strain and drug resistant strains	4
Evaluation of changes in drug susceptibility and population genetic structure in Haemonchus contortus following worm replacement as a means to reverse the impact of multiple-anthelmintic resistance on	4
Activity of (1-benzyl-4-triazolyl)-indole-2-carboxamides against Toxoplasma gondii and Cryptosporidium parvum	4
Increased copy number of the target gene squalene monooxygenase as the main resistance mechanism to terbinafine in Leishmania infantum	4
In vitro and in vivo anti-Cryptosporidium and anti-inflammatory effects of Aloe vera gel in dexamethasone immunosuppressed mice	4
Histone deacetylase inhibitor AR-42 and achiral analogues kill malaria parasites in vitro and in mice	4
The therapeutic potential of novel isobenzofuranones against Naegleria fowleri	4
Exploring therapeutic approaches against Naegleria fowleri infections through the COVID box	4
Molecular characterization and analysis of drug resistance-associated protein enolase 2 of Eimeria tenella	4
Treating cryptosporidiosis: A review on drug discovery strategies	4
Potent and selective antiplasmodial activity of marine sponges from Bahia state, Brazil	4
Treatment of human intestinal cryptosporidiosis: A review of published clinical trials	4
Selective activity of Tabebuia avellanedae against Giardia duodenalis infecting organoid-derived human gastrointestinal epithelia	4
Surveillance of molecular markers of Plasmodium falciparum artemisinin resistance (kelch13 mutations) in Papua New Guinea between 2016 and 2018	4
The effect of sickle cell genotype on the pharmacokinetic properties of artemether-lumefantrine in Tanzanian children	4
Structure-activity relationship and target investigation of 2-aryl quinolines with nematocidal activity	3
Apparent treatment failure of praziquantel and pyrantel pamoate against anoplocephalid tapeworms	3
Herbal-based compounds: A review on treatments of cryptosporidiosis	3
The binuclear cyclopalladated complex CP2 is targeting ubiquinol-cytochrome c reductase (complex III) of Leishmania amazonensis	3
Ascaridia galli - An old problem that requires new solutions	3
First case of macrocyclic lactone-resistant Dirofilaria immitis in Europe - Cause for concern	3
Inhibitory effect of morin on aldolase 2 from Eimeria tenella	3
Effect of the pseudomonas metabolites HQNO on the Toxoplasma gondii RH strain in vitro and in vivo	3
Artemisinin-based combination therapy (ACT) and drug resistance molecular markers: A systematic review of clinical studies from two malaria endemic regions – India and sub-Saharan Africa	3
Nitroxoline evidence amoebicidal activity against Acanthamoeba castellanii through DNA damage and the stress response pathways	3
3-nitroimidazo[1,2-b]pyridazine as a novel scaffold for antiparasitics with sub-nanomolar anti-Giardia lamblia activity	3
Identification of new drug candidates against Trichomonas gallinae using high-throughput screening	3
Anti-protozoal activity of Thymol and a Thymol ester against Cryptosporidium parvum in cell culture	3
Transcriptomic analysis of albendazole resistance in human diarrheal parasite Giardia duodenalis	3
In vitro activity and mechanism of cell death induction of cyanomethyl vinyl ethers derivatives against Trypanosoma cruzi	3
Increased activity of CF3-derivatized levamisole at the ACC-2 receptor from the parasitic nematode Haemonchus contortus	3
Multiple anthelmintic drug resistant Ancylostoma caninum in foxhounds	3