OOIR: Observatory of International Research

Papers

(The median citation count of International Journal for Parasitology-Drugs and Drug Resistance is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Drug resistance in liver flukes	101
Current trends in the pharmacological management of Chagas disease	79
Where are all the anthelmintics? Challenges and opportunities on the path to new anthelmintics	52
Heartworm disease – Overview, intervention, and industry perspective	47
Caenorhabditis elegans in anthelmintic research – Old model, new perspectives	44
A review of the frequencies of Plasmodium falciparum Kelch 13 artemisinin resistance mutations in Africa	42
Quantitative benzimidazole resistance and fitness effects of parasitic nematode beta-tubulin alleles	41
Challenges and opportunities for the adoption of molecular diagnostics for anthelmintic resistance	41
Anthelmintic resistance in equine nematodes: Current status and emerging trends	39
Importation of macrocyclic lactone resistant cyathostomins on a US thoroughbred farm	39
Artemisinin-based combination therapy (ACT) and drug resistance molecular markers: A systematic review of clinical studies from two malaria endemic regions – India and sub-Saharan Africa	39
Plasmodium falciparum resistance to ACTs: Emergence, mechanisms, and outlook	38
The molecular basis of antimalarial drug resistance in Plasmodium vivax	37
Monitoring Plasmodium vivax resistance to antimalarials: Persisting challenges and future directions	30
Multiple drug resistance in hookworms infecting greyhound dogs in the USA	29
Praziquantel use in aquaculture – Current status and emerging issues	25
Efficacy evaluation of anthelmintic products against an infection with the canine hookworm (Ancylostoma caninum) isolate Worthy 4.1F3P in dogs	23
HDAC inhibitors Tubastatin A and SAHA affect parasite cell division and are potential anti-Toxoplasma gondii chemotherapeutics	21
Drug repurposing applied: Activity of the anti-malarial mefloquine against Echinococcus multilocularis	21
The use of ITS-2 rDNA nemabiome metabarcoding to enhance anthelmintic resistance diagnosis and surveillance of ovine gastrointestinal nematodes	21
Newly identified parasitic nematode beta-tubulin alleles confer resistance to benzimidazoles	20
Spread of anthelmintic resistance in intestinal helminths of dogs and cats is currently less pronounced than in ruminants and horses – Yet it is of major concern	19
Curcuma longa rhizome extract and Curcumin reduce the adhesion of Acanthamoeba triangularis trophozoites and cysts in polystyrene plastic surface and contact lens	18
Focused review: The role of drug combinations for the control of coccidiosis in commercially reared chickens	18
Large scale screening for benzimidazole resistance mutations in Nematodirus battus, using both pyrosequence genotyping and deep amplicon sequencing, indicates the early emergence of resistance on UK s	17

A new paraprobiotic-based treatment for control of Haemonchus contortus in sheep	17
A review study on the anti-trichomonas activities of medicinal plants	17
In vitro activity, safety and in vivo efficacy of the novel bumped kinase inhibitor BKI-1748 in non-pregnant and pregnant mice experimentally infected with Neospora caninum tachyzoites and Toxoplasma	17
MRPA-independent mechanisms of antimony resistance in Leishmania infantum	16
Treatment of human intestinal cryptosporidiosis: A review of published clinical trials	16
Naphthylisoquinoline alkaloids, validated as hit multistage antiplasmodial natural products	16
Identification of compounds responsible for the anthelmintic effects of chicory (Cichorium intybus) by molecular networking and bio-guided fractionation	16
Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum?	15
Surveillance of molecular markers of Plasmodium falciparum artemisinin resistance (kelch13 mutations) in Papua New Guinea between 2016 and 2018	15
Widespread resistance mutations to sulfadoxine-pyrimethamine in malaria parasites imported to China from Central and Western Africa	15
Impact of clinically acquired miltefosine resistance by Leishmania infantum on mouse and sand fly infection	14
Evaluation of the in vitro susceptibility of various filarial nematodes to emodepside	14
Natural variation in Caenorhabditis elegans responses to the anthelmintic emodepside	14
Egg reappearance periods of anthelmintics against equine cyathostomins: The state of play revisited	14
In vitro and in vivo anti-Cryptosporidium and anti-inflammatory effects of Aloe vera gel in dexamethasone immunosuppressed mice	14
Genetic surveillance for monitoring the impact of drug use on Plasmodium falciparum populations	14
Mefloquine as a prophylaxis for malaria needs to be revisited	13
The first report of macrocyclic lactone resistant cyathostomins in the UK	13
The ultimate fate determinants of drug induced cell-death mechanisms in Trypanosomatids	13
Mode of action of a formulation containing hydrazones and saponins against leishmania spp. Role in mitochondria, proteases and reinfection process	12
Exploring the β-tubulin gene family in a benzimidazole-resistant Parascaris univalens population	12
Repurposing bioenergetic modulators against protozoan parasites responsible for tropical diseases	12
In vitro activity of Camellia sinensis (green tea) against trophozoites and cysts of Acanthamoeba castellanii	11
Evaluation of the therapeutic efficacy of praziquantel against schistosomes in seven countries with ongoing large-scale deworming programs	11
Advances in our understanding of nematode ion channels as potential anthelmintic targets	11
Primaquine for Plasmodium vivax radical cure: What we do not know and why it matters	11
Schistosome TRP channels: An appraisal	11
Identification of annotated bioactive molecules that impair motility of the blood fluke Schistosoma mansoni	11
Climate change is likely to increase the development rate of anthelmintic resistance in equine cyathostomins in New Zealand	11
Activity of paromomycin against Leishmania amazonensis: Direct correlation between susceptibility in vitro and the treatment outcome in vivo	10
Nullscript inhibits Cryptosporidium and Toxoplasma growth	10
Antiplasmodial activity of the natural product compounds alstonine and himbeline	10
Dicyclanil resistance in the Australian sheep blowfly, Lucilia cuprina, substantially reduces flystrike protection by dicyclanil and cyromazine based products	10
Short-course quinazoline drug treatments are effective in the Litomosoides sigmodontis and Brugia pahangi jird models	10
Nucleoside analogues for the treatment of animal trypanosomiasis	10
Evaluation of changes in drug susceptibility and population genetic structure in Haemonchus contortus following worm replacement as a means to reverse the impact of multiple-anthelmintic resistance on	10
In vitro evaluation of new 4-thiazolidinones on invasion and growth of Toxoplasma gondii	10
Rational approach to drug discovery for human schistosomiasis	9
A retrospective cohort study of the effectiveness and adverse events of intralesional pentavalent antimonials in the treatment of cutaneous leishmaniasis	9
Copper detoxification machinery of the brain-eating amoeba Naegleria fowleri involves copper-translocating ATPase and the antioxidant system	9
Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity	8
Using droplet digital PCR for the detection of hco-acr-8b levamisole resistance marker in H. contortus	8
Reflecting on the past and fast forwarding to present day anthelmintic resistant Ancylostoma caninum–A critical issue we neglected to forecast	8
Molecular characterization and analysis of the ATPase ASNA1 homolog gene of Eimeria tenella in a drug sensitive strain and drug resistant strains	8
Integration of population and functional genomics to understand mechanisms of artemisinin resistance in Plasmodium falciparum	8
Emergence of Ancylostoma caninum parasites with the benzimidazole resistance F167Y polymorphism in the US dog population	8
Antileishmanial activity of a new chloroquine analog in an animal model of Leishmania panamensis infection	8
Allele specific PCR for a major marker of levamisole resistance in Haemonchus contortus	8
Novel flavanones with anti-trypanosomal activity isolated from Zambian and Tanzanian propolis samples	8
Endochin-like quinolones (ELQs) and bumped kinase inhibitors (BKIs): Synergistic and additive effects of combined treatments against Neospora caninum infection in vitro and in vivo	7

Cholinergic receptors on intestine cells of Ascaris suum and activation of nAChRs by levamisole	7
Current and emerging target identification methods for novel antimalarials	7
Anti-protozoal activity of Thymol and a Thymol ester against Cryptosporidium parvum in cell culture	7
Route of administration influences the concentration of ivermectin reaching nematode parasites in the gastrointestinal tract of cattle	7
TriTOX: A novel Trichomonas vaginalis assay platform for high-throughput screening of compound libraries	7
Apparent treatment failure of praziquantel and pyrantel pamoate against anoplocephalid tapeworms	7
Rapid determination of nematode cell and organ susceptibility to toxic treatments	7
Nicotinic acetylcholine receptors in the synganglion of the tick Ixodes ricinus: Functional characterization using membrane microtransplantation	6
6-Methyl-7-deazapurine nucleoside analogues as broad-spectrum antikinetoplastid agents	6
Evidence for linkage of pfmdr1, pfcrt, and pfk13 polymorphisms to lumefantrine and mefloquine susceptibilities in a Plasmodium falciparum cross	6
Sterol profiling of Leishmania parasites using a new HPLC-tandem mass spectrometry-based method and antifungal azoles as chemical probes reveals a key intermediate sterol that supports a branched ergo	6
A conserved coccidian gene is involved in Toxoplasma sensitivity to the anti-apicomplexan compound, tartrolon E	6
A short-term treatment with BKI-1294 does not protect foetuses from sheep experimentally infected with Neospora caninum tachyzoites during pregnancy	6
Transdermal delivery of artemisinins for treatment of pre-clinical cerebral malaria	6
In vitro selection of Giardia duodenalis for Albendazole resistance identifies a β-tubulin mutation at amino acid E198K	6
Ex vivo susceptibility to new antimalarial agents differs among human-infecting Plasmodium species	5
In vitro evaluation of Resveratrol as a potential pre-exposure prophylactic drug against Trypanosoma cruzi infection	5
In vitro evaluation of commercial foam Belcils® on Acanthamoeba spp	5
Dealing with double trouble: Combination deworming against double-drug resistant cyathostomins	5
Comparison of electrophysiological and motility assays to study anthelmintic effects in Caenorhabditis elegans	5
Repurposing the open access malaria box reveals compounds with activity against Tritrichomonas foetus trophozoites	5
3-nitroimidazo[1,2-b]pyridazine as a novel scaffold for antiparasitics with sub-nanomolar anti-Giardia lamblia activity	5
Thiophene derivatives activity against the protozoan parasite Leishmania infantum	5
Detection of target-site and metabolic resistance to pyrethroids in the bed bug Cimex lectularius in Berlin, Germany	4
Proteomic characterization of Toxoplasma gondii ME49 derived strains resistant to the artemisinin derivatives artemiside and artemisone implies potential mode of action independent of ROS formation	4
Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization	4
RNA interference dynamics in juvenile Fasciola hepatica are altered during in vitro growth and development	4
Identification of lobetyolin as a major antimalarial constituent of the roots of Lobelia giberroa Hemsl	4
Longitudinal ex vivo and molecular trends of chloroquine and piperaquine activity against Plasmodium falciparum and P. vivax before and after introduction of artemisinin-based combination therapy in P	4
Characterization of a P-glycoprotein drug transporter from Toxocara canis with a novel pharmacological profile	4
In vivo efficiency of praziquantel treatment of single-sex Schistosoma japonicum aged three months old in mice	4
Physiological and proteomic profiles of Trypanosoma brucei rhodesiense parasite isolated from suramin responsive and non-responsive HAT patients in Busoga, Uganda	4
Poor adherence is a major barrier to the proper treatment of cutaneous leishmaniasis: A case-control field assessment in Iran	4
The presence and relative frequency detection of the levamisole-resistance-associated S168T substitution in hco-acr-8 in Haemonchus contortus	4
Genetic diversity in the metronidazole metabolism genes nitroreductases and pyruvate ferredoxin oxidoreductases in susceptible and refractory clinical samples of Giardia lamblia	4
Antiamoeboid activity of squamins C–F, cyclooctapeptides from Annona globifora	4
Novel acyl carbamates and acyl / diacyl ureas show in vitro efficacy against Toxoplasma gondii and Cryptosporidium parvum	4