OOIR: Observatory of International Research

Papers

(The median citation count of International Journal for Parasitology-Drugs and Drug Resistance is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Pharmacokinetic and pharmacodynamic considerations for treating sarcoptic mange with cross-relevance to Australian wildlife	80
In vivo efficiency of praziquantel treatment of single-sex Schistosoma japonicum aged three months old in mice	75
Phenotypic and genotypic analysis of benzimidazole resistance in reciprocal genetic crosses of Haemonchus contortus	68
The presence and relative frequency detection of the levamisole-resistance-associated S168T substitution in hco-acr-8 in Haemonchus contortus	62
Forward genetic analysis of monensin and diclazuril resistance in Eimeria tenella	55
Diethylcarbamazine mediated potentiation of emodepside induced paralysis requires TRP-2 in adult Brugia malayi	52
Efficacy of the treatment using a microemulsion loaded with epoxy-α-lapachone in combination with meglumine antimoniate against murine infection by Leishmania (Leishmania) amazonensis	38
Comparison of electrophysiological and motility assays to study anthelmintic effects in Caenorhabditis elegans	35
Anthelmintic resistance in equine nematodes: Current status and emerging trends	34
Potent and selective antiplasmodial activity of marine sponges from Bahia state, Brazil	33
Investigation of risk factors associated with Ancylostoma spp. infection and the benzimidazole F167Y resistance marker polymorphism in dogs from the United States	23
In vitro and in vivo anti-Cryptosporidium and anti-inflammatory effects of Aloe vera gel in dexamethasone immunosuppressed mice	23
The Haemonchus contortus LGC-39 subunit is a novel subtype of an acetylcholine-gated chloride channel	22
The therapeutic potential of novel isobenzofuranones against Naegleria fowleri	22
Identification of new drug candidates against Trichomonas gallinae using high-throughput screening	21
Transcriptomic analysis of albendazole resistance in human diarrheal parasite Giardia duodenalis	21
The faecal egg count reduction test: Will identification of larvae to species improve its utility?	20
Newly identified parasitic nematode beta-tubulin alleles confer resistance to benzimidazoles	20
Yeast-based assay to identify inhibitors of the malaria parasite sodium phosphate uptake transporter as potential novel antimalarial drugs	19
A national survey of anthelmintic resistance in ascarid and strongylid nematodes in Australian Thoroughbred horses	18
In vitro selection of Giardia duodenalis for Albendazole resistance identifies a β-tubulin mutation at amino acid E198K	18
Pantothenate biosynthesis in Toxoplasma gondii tachyzoites is not a drug target	18
Endochin-like quinolones (ELQs) and bumped kinase inhibitors (BKIs): Synergistic and additive effects of combined treatments against Neospora caninum infection in vitro and in vivo	17
Integrated application of transcriptomics and metabolomics provides insight into the mechanism of Eimeria tenella resistance to maduramycin	17
The induction and inhibition of UDP-glycosyltransferases in Haemonchus contortus and their role in the metabolism of albendazole	16

Effects of the G-quadruplex-binding drugs quarfloxin and CX-5461 on the malaria parasite Plasmodium falciparum	16
Emergence of Ancylostoma caninum parasites with the benzimidazole resistance F167Y polymorphism in the US dog population	15
Combining the zebrafish embryo developmental toxicity assay (ZEDTA) with hemoglobin staining to accelerate the research of novel antimalarial drugs for pregnant women	15
MEFAS, a hybrid of artesunate-mefloquine active against asexual stages of Plasmodium vivax in field isolates, inhibits malaria transmission	14
In vitro amoebicidal effects of arabinogalactan-based ophthalmic solution	14
Current and emerging target identification methods for novel antimalarials	14
In artemisinin-resistant falciparum malaria parasites, mitochondrial metabolic pathways are essential for survival but not those of apicoplast	13
In vitro and in vivo activity evaluation and mode of action of broxaldine on Toxoplasma gondii	13
Rational approach to drug discovery for human schistosomiasis	12
Benzimidazole F167Y polymorphism in the canine hookworm, Ancylostoma caninum: Widespread geographic, seasonal, age, and breed distribution in United States and Canada dogs	11
Thiophene derivatives activity against the protozoan parasite Leishmania infantum	11
Phylogenetic and transcriptomic study of aldo-keto reductases in Haemonchus contortus and their inducibility by flubendazole	10
Nitroxoline evidence amoebicidal activity against Acanthamoeba castellanii through DNA damage and the stress response pathways	10
In vivo efficacy of pyrantel pamoate as a post-exposure prophylactic for rat lungworm (Angiostrongylus cantonensis)	10
Molecular characterization and analysis of drug resistance-associated protein enolase 2 of Eimeria tenella	10
Spread of anthelmintic resistance in intestinal helminths of dogs and cats is currently less pronounced than in ruminants and horses – Yet it is of major concern	10
Therapeutic advantages of the combined use of closantel and moxidectin in lambs parasitized with resistant gastrointestinal nematodes	9
New diarylsulfonamide inhibitors of Leishmania infantum amastigotes	9
Anti-malarial activity of HCl salt of SKM13 (SKM13-2HCl)	9
6-Methyl-7-deazapurine nucleoside analogues as broad-spectrum antikinetoplastid agents	9
Faecal egg count reduction tests and nemabiome analysis reveal high frequency of multi-resistant parasites on sheep farms in north-east Germany involving multiple strongyle parasite species	8
High-throughput prioritization of target proteins for development of new antileishmanial compounds	8
Nucleoside analogues for the treatment of animal trypanosomiasis	8
Effect of Phlebotomus papatasi on the fitness, infectivity and antimony-resistance phenotype of antimony-resistant Leishmania major Mon-25	8
Insights from the use of erythropoietin in experimental Chagas disease	8
Quantitative DNA metabarcoding reveals species composition of a macrocyclic lactone and pyrantel resistant cyathostomin population in the UK	8
Suramin action in African trypanosomes involves a RuvB-like DNA helicase	7
Natural marine products as antiprotozoal agents against amitochondrial parasites	7
Reflecting on the past and fast forwarding to present day anthelmintic resistant Ancylostoma caninum–A critical issue we neglected to forecast	7
Acaricide resistance status of livestock ticks from East and West Africa and in vivo efficacy of acaricides to control them	7
In vitro evaluation of new 4-thiazolidinones on invasion and growth of Toxoplasma gondii	7
Plasmodium falciparum resistance to ACTs: Emergence, mechanisms, and outlook	7
Screening of the activity of sixty essential oils against plasmodium early mosquito stages in vitro and machine learning analysis reveals new putative inhibitors of malaria parasites	7
Plasmodium RNA triphosphatase validation as antimalarial target	7
Efficacy of fenbendazole against gastrointestinal nematodes in naturally infected goats in Maputo Province, Mozambique using in vivo, in vitro and molecular assessment	7
Modified dosing schedule efficacy of fosmidomycin and clindamycin against murine malaria Plasmodium berghei	7
Characterization of a P-glycoprotein drug transporter from Toxocara canis with a novel pharmacological profile	6
Repurposing in vitro approaches for screening anti-parasitic drugs against the brain-eating amoeba Naegleria fowleri	6
Egg reappearance periods of anthelmintics against equine cyathostomins: The state of play revisited	6
Effect of urea and squaramide IMPDH inhibitors on C. parvum : in vitro trial design impacts the assessment of drug efficacy.	6
A graphical user interface for wrmXpress 2.0 streamlines helminth phenotypic screening	6
Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization	6
The effect of sickle cell genotype on the pharmacokinetic properties of artemether-lumefantrine in Tanzanian children	6
MMV560185 from pathogen box induces extrinsic pathway of apoptosis in Theileria annulata infected bovine leucocytes	5
In vitro activity and mechanism of cell death induction of cyanomethyl vinyl ethers derivatives against Trypanosoma cruzi	5
Inhibition of Giardia duodenalis by isocryptolepine -triazole adducts and derivatives	5
Structure-activity relationship and target investigation of 2-aryl quinolines with nematocidal activity	5
Revisiting anthelmintic resistance in sheep flocks from São Paulo State, Brazil	5
Efficacy of flukicides against Fasciola hepatica and first report of triclabendazole resistance on German sheep farms	5
Drug resistance in animal trypanosomiases: Epidemiology, mechanisms and control strategies	5

Inhibitory effect of morin on aldolase 2 from Eimeria tenella	5
Exploring therapeutic approaches against Naegleria fowleri infections through the COVID box	5
Robenidine derivatives as potential antischistosomal drug candidates	5
3-nitroimidazo[1,2-b]pyridazine as a novel scaffold for antiparasitics with sub-nanomolar anti-Giardia lamblia activity	5
Profile of molecular markers of Sulfadoxine-Pyrimethamine-resistant Plasmodium falciparum in individuals living in southern area of Brazzaville, Republic of Congo	5
Ouabain, ATPase inhibitor, potentially enhances the effect of polyhexamethylene biguanide on Acanthamoeba castellanii	4
Anti-protozoal activity and metabolomic analyses of Cichorium intybus L. against Trypanosoma cruzi	4
Identification and characterization of novel marine oxasqualenoid yucatecone against Naegleria fowleri	4
Genome-wide analysis of the response to ivermectin treatment by a Swedish field population of Haemonchus contortus	4
Macrocyclic lactones and ectoparasites control in livestock: Efficacy, drug resistance and therapeutic challenges	4
Multiple anthelmintic drug resistant Ancylostoma caninum in foxhounds	4
A multiplexed high throughput screening assay using flow cytometry identifies glycolytic molecular probes in bloodstream form Trypanosoma brucei	4
Genomic analysis of Indian isolates of Plasmodium falciparum: Implications for drug resistance and virulence factors	4
Efficacy of the bumped kinase inhibitor BKI-1708 against the cyst-forming apicomplexan parasites Toxoplasma gondii and Neospora caninum in vitro and in experimentally infected mice	4
Multiple drug resistance in hookworms infecting greyhound dogs in the USA	4
Benzaldehyde stimulates autophagy via the sonic hedgehog signaling pathway in mouse brain astrocytes after treatment with Angiostrongylus cantonensis excretory-secretory products	4
Focused review: The role of drug combinations for the control of coccidiosis in commercially reared chickens	4
A short-term treatment with BKI-1294 does not protect foetuses from sheep experimentally infected with Neospora caninum tachyzoites during pregnancy	4
Exploration of the sensitivity to macrocyclic lactones in the canine heartworm (Dirofilaria immitis) in Australia using phenotypic and genotypic approaches	4
Lumefantrine attenuates Plasmodium falciparum artemisinin resistance during the early ring stage	3
Antiplasmodial activity of the natural product compounds alstonine and himbeline	3
Proteomic characterization of Toxoplasma gondii ME49 derived strains resistant to the artemisinin derivatives artemiside and artemisone implies potential mode of action independent of ROS formation	3
Surveillance of molecular markers of Plasmodium falciparum artemisinin resistance (kelch13 mutations) in Papua New Guinea between 2016 and 2018	3
Thieno[3,2-b]pyrrole 5-carboxamides as potent and selective inhibitors of Giardia duodenalis	3
Evaluation of topotecan and 10-hydroxycamptothecin on Toxoplasma gondii: Implications on baseline DNA damage and repair efficiency	3
Exploring the β-tubulin gene family in a benzimidazole-resistant Parascaris univalens population	3
Evaluation of the inhibitory efficacy of quaternary ammonium compounds on in vitro growth of Theileria equi parasite in MASP culture	3
Heartworm disease – Overview, intervention, and industry perspective	3
Genetic diversity in the metronidazole metabolism genes nitroreductases and pyruvate ferredoxin oxidoreductases in susceptible and refractory clinical samples of Giardia lamblia	3
Comparative structure activity and target exploration of 1,2-diphenylethynes in Haemonchus contortus and Caenorhabditis elegans	3
3′-deoxytubercidin: A potent therapeutic candidate for the treatment of Surra and Dourine	3
The phosphatase inhibitor BVT-948 can be used to efficiently screen functional sexual development proteins in the malaria parasite Plasmodium berghei	3
Genetic surveillance for monitoring the impact of drug use on Plasmodium falciparum populations	3
Integration of population and functional genomics to understand mechanisms of artemisinin resistance in Plasmodium falciparum	3
Selenosugars targeting the infective stage of Trypanosoma brucei with high selectivity	3
Rapid detection of mutations in the suspected piperaquine resistance gene E415G-exo in Plasmodium falciparum exonuclease via AS‒PCR and RAA with CRISPR/Cas12a	3