OOIR: Observatory of International Research

Papers

(The median citation count of International Journal for Parasitology-Drugs and Drug Resistance is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
In vivo efficiency of praziquantel treatment of single-sex Schistosoma japonicum aged three months old in mice	94
Phenotypic and genotypic analysis of benzimidazole resistance in reciprocal genetic crosses of Haemonchus contortus	61
Pharmacokinetic and pharmacodynamic considerations for treating sarcoptic mange with cross-relevance to Australian wildlife	45
Anthelmintic resistance in equine nematodes: Current status and emerging trends	43
The presence and relative frequency detection of the levamisole-resistance-associated S168T substitution in hco-acr-8 in Haemonchus contortus	43
Forward genetic analysis of monensin and diclazuril resistance in Eimeria tenella	40
Diethylcarbamazine mediated potentiation of emodepside induced paralysis requires TRP-2 in adult Brugia malayi	32
Efficacy of the treatment using a microemulsion loaded with epoxy-α-lapachone in combination with meglumine antimoniate against murine infection by Leishmania (Leishmania) amazonensis	30
The therapeutic potential of novel isobenzofuranones against Naegleria fowleri	26
In vitro and in vivo anti-Cryptosporidium and anti-inflammatory effects of Aloe vera gel in dexamethasone immunosuppressed mice	26
Potent and selective antiplasmodial activity of marine sponges from Bahia state, Brazil	25
Investigation of risk factors associated with Ancylostoma spp. infection and the benzimidazole F167Y resistance marker polymorphism in dogs from the United States	24
The faecal egg count reduction test: Will identification of larvae to species improve its utility?	23
Newly identified parasitic nematode beta-tubulin alleles confer resistance to benzimidazoles	23
Integrated application of transcriptomics and metabolomics provides insight into the mechanism of Eimeria tenella resistance to maduramycin	22
Transcriptomic analysis of albendazole resistance in human diarrheal parasite Giardia duodenalis	22
Yeast-based assay to identify inhibitors of the malaria parasite sodium phosphate uptake transporter as potential novel antimalarial drugs	22
Identification of new drug candidates against Trichomonas gallinae using high-throughput screening	22
The Haemonchus contortus LGC-39 subunit is a novel subtype of an acetylcholine-gated chloride channel	22
Pantothenate biosynthesis in Toxoplasma gondii tachyzoites is not a drug target	21
A national survey of anthelmintic resistance in ascarid and strongylid nematodes in Australian Thoroughbred horses	20
The induction and inhibition of UDP-glycosyltransferases in Haemonchus contortus and their role in the metabolism of albendazole	18
Endochin-like quinolones (ELQs) and bumped kinase inhibitors (BKIs): Synergistic and additive effects of combined treatments against Neospora caninum infection in vitro and in vivo	17
Combining the zebrafish embryo developmental toxicity assay (ZEDTA) with hemoglobin staining to accelerate the research of novel antimalarial drugs for pregnant women	17
Effects of the G-quadruplex-binding drugs quarfloxin and CX-5461 on the malaria parasite Plasmodium falciparum	17

MEFAS, a hybrid of artesunate-mefloquine active against asexual stages of Plasmodium vivax in field isolates, inhibits malaria transmission	15
Current and emerging target identification methods for novel antimalarials	15
Emergence of Ancylostoma caninum parasites with the benzimidazole resistance F167Y polymorphism in the US dog population	14
Mechanistic, in-silico and in vitro studies with nitrofurans reveal potent leishmanicidal activity and inhibition of trypanothione reductase	13
In artemisinin-resistant falciparum malaria parasites, mitochondrial metabolic pathways are essential for survival but not those of apicoplast	13
Benzimidazole F167Y polymorphism in the canine hookworm, Ancylostoma caninum: Widespread geographic, seasonal, age, and breed distribution in United States and Canada dogs	12
In vitro and in vivo activity evaluation and mode of action of broxaldine on Toxoplasma gondii	12
Molecular characterization and analysis of drug resistance-associated protein enolase 2 of Eimeria tenella	12
Thiophene derivatives activity against the protozoan parasite Leishmania infantum	12
Phylogenetic and transcriptomic study of aldo-keto reductases in Haemonchus contortus and their inducibility by flubendazole	12
Nitroxoline evidence amoebicidal activity against Acanthamoeba castellanii through DNA damage and the stress response pathways	11
Spread of anthelmintic resistance in intestinal helminths of dogs and cats is currently less pronounced than in ruminants and horses – Yet it is of major concern	11
Ursolic acid induces apoptosis and disrupts host-parasite interactions in Theileria annulata-infected cells	11
In vivo efficacy of pyrantel pamoate as a post-exposure prophylactic for rat lungworm (Angiostrongylus cantonensis)	11
Anti-malarial activity of HCl salt of SKM13 (SKM13-2HCl)	10
Therapeutic advantages of the combined use of closantel and moxidectin in lambs parasitized with resistant gastrointestinal nematodes	10
Quantitative DNA metabarcoding reveals species composition of a macrocyclic lactone and pyrantel resistant cyathostomin population in the UK	10
6-Methyl-7-deazapurine nucleoside analogues as broad-spectrum antikinetoplastid agents	10
Faecal egg count reduction tests and nemabiome analysis reveal high frequency of multi-resistant parasites on sheep farms in north-east Germany involving multiple strongyle parasite species	9
Plasmodium RNA triphosphatase validation as antimalarial target	9
Efficacy of fenbendazole against gastrointestinal nematodes in naturally infected goats in Maputo Province, Mozambique using in vivo, in vitro and molecular assessment	9
Effect of Phlebotomus papatasi on the fitness, infectivity and antimony-resistance phenotype of antimony-resistant Leishmania major Mon-25	9
Nucleoside analogues for the treatment of animal trypanosomiasis	9
Modified dosing schedule efficacy of fosmidomycin and clindamycin against murine malaria Plasmodium berghei	9
Acaricide resistance status of livestock ticks from East and West Africa and in vivo efficacy of acaricides to control them	9
High-throughput prioritization of target proteins for development of new antileishmanial compounds	9
Insights from the use of erythropoietin in experimental Chagas disease	9
Reflecting on the past and fast forwarding to present day anthelmintic resistant Ancylostoma caninum–A critical issue we neglected to forecast	9
Characterization of a P-glycoprotein drug transporter from Toxocara canis with a novel pharmacological profile	8
A graphical user interface for wrmXpress 2.0 streamlines helminth phenotypic screening	8
Suramin action in African trypanosomes involves a RuvB-like DNA helicase	8
Egg reappearance periods of anthelmintics against equine cyathostomins: The state of play revisited	8
Natural marine products as antiprotozoal agents against amitochondrial parasites	8
Effect of urea and squaramide IMPDH inhibitors on C. parvum: in vitro trial design impacts the assessment of drug efficacy	8
Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization	8
Screening of the activity of sixty essential oils against plasmodium early mosquito stages in vitro and machine learning analysis reveals new putative inhibitors of malaria parasites	8
Robenidine derivatives as potential antischistosomal drug candidates	7
Repurposing in vitro approaches for screening anti-parasitic drugs against the brain-eating amoeba Naegleria fowleri	7
Profile of molecular markers of Sulfadoxine-Pyrimethamine-resistant Plasmodium falciparum in individuals living in southern area of Brazzaville, Republic of Congo	7
Inhibitory effect of morin on aldolase 2 from Eimeria tenella	7
Structure-activity relationship and target investigation of 2-aryl quinolines with nematocidal activity	7
Exploring therapeutic approaches against Naegleria fowleri infections through the COVID box	7
The effect of sickle cell genotype on the pharmacokinetic properties of artemether-lumefantrine in Tanzanian children	7
Revisiting anthelmintic resistance in sheep flocks from São Paulo State, Brazil	7
Inhibition of Giardia duodenalis by isocryptolepine -triazole adducts and derivatives	6
Multiple anthelmintic drug resistant Ancylostoma caninum in foxhounds	6
Efficacy of flukicides against Fasciola hepatica and first report of triclabendazole resistance on German sheep farms	6
Focused review: The role of drug combinations for the control of coccidiosis in commercially reared chickens	6
Identification and characterization of novel marine oxasqualenoid yucatecone against Naegleria fowleri	6
Ouabain, ATPase inhibitor, potentially enhances the effect of polyhexamethylene biguanide on Acanthamoeba castellanii	6

MMV560185 from pathogen box induces extrinsic pathway of apoptosis in Theileria annulata infected bovine leucocytes	6
A multiplexed high throughput screening assay using flow cytometry identifies glycolytic molecular probes in bloodstream form Trypanosoma brucei	6
Anti-protozoal activity and metabolomic analyses of Cichorium intybus L. against Trypanosoma cruzi	6
Benzaldehyde stimulates autophagy via the sonic hedgehog signaling pathway in mouse brain astrocytes after treatment with Angiostrongylus cantonensis excretory-secretory products	6
3-nitroimidazo[1,2-b]pyridazine as a novel scaffold for antiparasitics with sub-nanomolar anti-Giardia lamblia activity	6
Macrocyclic lactones and ectoparasites control in livestock: Efficacy, drug resistance and therapeutic challenges	6
In vitro activity and mechanism of cell death induction of cyanomethyl vinyl ethers derivatives against Trypanosoma cruzi	6
Multiple drug resistance in hookworms infecting greyhound dogs in the USA	6
Drug resistance in animal trypanosomiases: Epidemiology, mechanisms and control strategies	6
3′-deoxytubercidin: A potent therapeutic candidate for the treatment of Surra and Dourine	5
Rapid detection of mutations in the suspected piperaquine resistance gene E415G-exo in Plasmodium falciparum exonuclease via AS‒PCR and RAA with CRISPR/Cas12a	5
Genome-wide analysis of the response to ivermectin treatment by a Swedish field population of Haemonchus contortus	5
Evaluation of the inhibitory efficacy of quaternary ammonium compounds on in vitro growth of Theileria equi parasite in MASP culture	5
A short-term treatment with BKI-1294 does not protect foetuses from sheep experimentally infected with Neospora caninum tachyzoites during pregnancy	5
Exploration of the sensitivity to macrocyclic lactones in the canine heartworm (Dirofilaria immitis) in Australia using phenotypic and genotypic approaches	5
Evaluation of topotecan and 10-hydroxycamptothecin on Toxoplasma gondii: Implications on baseline DNA damage and repair efficiency	5
Genomic analysis of Indian isolates of Plasmodium falciparum: Implications for drug resistance and virulence factors	5
Efficacy of the bumped kinase inhibitor BKI-1708 against the cyst-forming apicomplexan parasites Toxoplasma gondii and Neospora caninum in vitro and in experimentally infected mice	5
Evaluation of the inhibitory effects of emodin on Neospora caninum invasion and proliferation in vitro	4
Lumefantrine attenuates Plasmodium falciparum artemisinin resistance during the early ring stage	4
Proteomic characterization of Toxoplasma gondii ME49 derived strains resistant to the artemisinin derivatives artemiside and artemisone implies potential mode of action independent of ROS formation	4
Antimalarial drug resistance and drug discovery: learning from the past to innovate the future	4
The phosphatase inhibitor BVT-948 can be used to efficiently screen functional sexual development proteins in the malaria parasite Plasmodium berghei	4
Genetic diversity in the metronidazole metabolism genes nitroreductases and pyruvate ferredoxin oxidoreductases in susceptible and refractory clinical samples of Giardia lamblia	4
Evaluation of the in vitro susceptibility of various filarial nematodes to emodepside	4
Exploring the β-tubulin gene family in a benzimidazole-resistant Parascaris univalens population	4
Comparative structure activity and target exploration of 1,2-diphenylethynes in Haemonchus contortus and Caenorhabditis elegans	4
Genetic surveillance for monitoring the impact of drug use on Plasmodium falciparum populations	4