OOIR: Observatory of International Research

Papers

(The median citation count of International Journal for Parasitology-Drugs and Drug Resistance is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Pharmacokinetic and pharmacodynamic considerations for treating sarcoptic mange with cross-relevance to Australian wildlife	98
In vivo efficiency of praziquantel treatment of single-sex Schistosoma japonicum aged three months old in mice	60
Phenotypic and genotypic analysis of benzimidazole resistance in reciprocal genetic crosses of Haemonchus contortus	47
Diethylcarbamazine mediated potentiation of emodepside induced paralysis requires TRP-2 in adult Brugia malayi	45
Forward genetic analysis of monensin and diclazuril resistance in Eimeria tenella	43
The presence and relative frequency detection of the levamisole-resistance-associated S168T substitution in hco-acr-8 in Haemonchus contortus	40
Efficacy of the treatment using a microemulsion loaded with epoxy-α-lapachone in combination with meglumine antimoniate against murine infection by Leishmania (Leishmania) amazonensis	32
Anthelmintic resistance in equine nematodes: Current status and emerging trends	30
The therapeutic potential of novel isobenzofuranones against Naegleria fowleri	27
Investigation of risk factors associated with Ancylostoma spp. infection and the benzimidazole F167Y resistance marker polymorphism in dogs from the United States	27
Comparative transcriptomics of naturally susceptible and resistant Trypanosoma cruzi strains in response to Benznidazole	26
In vitro and in vivo anti-Cryptosporidium and anti-inflammatory effects of Aloe vera gel in dexamethasone immunosuppressed mice	25
Potent and selective antiplasmodial activity of marine sponges from Bahia state, Brazil	24
Transcriptomic analysis of albendazole resistance in human diarrheal parasite Giardia duodenalis	24
The faecal egg count reduction test: Will identification of larvae to species improve its utility?	24
Identification of new drug candidates against Trichomonas gallinae using high-throughput screening	23
Integrated application of transcriptomics and metabolomics provides insight into the mechanism of Eimeria tenella resistance to maduramycin	22
The Haemonchus contortus LGC-39 subunit is a novel subtype of an acetylcholine-gated chloride channel	22
Yeast-based assay to identify inhibitors of the malaria parasite sodium phosphate uptake transporter as potential novel antimalarial drugs	22
Newly identified parasitic nematode beta-tubulin alleles confer resistance to benzimidazoles	22
Pantothenate biosynthesis in Toxoplasma gondii tachyzoites is not a drug target	20
Recent advances in intestinal helminth parasites of horses in the Asia-Pacific region: Current trends, challenges and future directions	19
A national survey of anthelmintic resistance in ascarid and strongylid nematodes in Australian Thoroughbred horses	18
The induction and inhibition of UDP-glycosyltransferases in Haemonchus contortus and their role in the metabolism of albendazole	18
Endochin-like quinolones (ELQs) and bumped kinase inhibitors (BKIs): Synergistic and additive effects of combined treatments against Neospora caninum infection in vitro and in vivo	17

Combining the zebrafish embryo developmental toxicity assay (ZEDTA) with hemoglobin staining to accelerate the research of novel antimalarial drugs for pregnant women	17
MEFAS, a hybrid of artesunate-mefloquine active against asexual stages of Plasmodium vivax in field isolates, inhibits malaria transmission	15
Effects of the G-quadruplex-binding drugs quarfloxin and CX-5461 on the malaria parasite Plasmodium falciparum	14
Emergence of Ancylostoma caninum parasites with the benzimidazole resistance F167Y polymorphism in the US dog population	14
In artemisinin-resistant falciparum malaria parasites, mitochondrial metabolic pathways are essential for survival but not those of apicoplast	13
Current and emerging target identification methods for novel antimalarials	13
Thiophene derivatives activity against the protozoan parasite Leishmania infantum	12
Mechanistic, in-silico and in vitro studies with nitrofurans reveal potent leishmanicidal activity and inhibition of trypanothione reductase	12
Benzimidazole F167Y polymorphism in the canine hookworm, Ancylostoma caninum: Widespread geographic, seasonal, age, and breed distribution in United States and Canada dogs	12
In vitro and in vivo activity evaluation and mode of action of broxaldine on Toxoplasma gondii	12
Phylogenetic and transcriptomic study of aldo-keto reductases in Haemonchus contortus and their inducibility by flubendazole	11
Molecular characterization and analysis of drug resistance-associated protein enolase 2 of Eimeria tenella	11
Challenges in applying W.A.A.V.P. criteria to diagnosing triclabendazole resistance in Fasciola hepatica, an example from the Southern Tablelands of New South Wales, Australia	11
Nitroxoline evidence amoebicidal activity against Acanthamoeba castellanii through DNA damage and the stress response pathways	11
Trialling the SmartWorm® application in New Zealand sheep farms	11
6-Methyl-7-deazapurine nucleoside analogues as broad-spectrum antikinetoplastid agents	10
Dual-targeting proteasome inhibitor ONX-0914 demonstrates potent antiplasmodial activity for malaria treatment	10
Quantitative DNA metabarcoding reveals species composition of a macrocyclic lactone and pyrantel resistant cyathostomin population in the UK	10
In vivo efficacy of pyrantel pamoate as a post-exposure prophylactic for rat lungworm (Angiostrongylus cantonensis)	10
Anti-malarial activity of HCl salt of SKM13 (SKM13-2HCl)	10
Therapeutic advantages of the combined use of closantel and moxidectin in lambs parasitized with resistant gastrointestinal nematodes	10
Spread of anthelmintic resistance in intestinal helminths of dogs and cats is currently less pronounced than in ruminants and horses – Yet it is of major concern	10
Faecal egg count reduction tests and nemabiome analysis reveal high frequency of multi-resistant parasites on sheep farms in north-east Germany involving multiple strongyle parasite species	9
Modified dosing schedule efficacy of fosmidomycin and clindamycin against murine malaria Plasmodium berghei	9
Insights from the use of erythropoietin in experimental Chagas disease	9
High-throughput prioritization of target proteins for development of new antileishmanial compounds	9
Effect of Phlebotomus papatasi on the fitness, infectivity and antimony-resistance phenotype of antimony-resistant Leishmania major Mon-25	9
Ribosomal protein L27 contributes to virulence and maduramicin resistance in Eimeria tenella	9
Evaluating the efficacy of different praziquantel treatment regimens using egg and circulating anodic antigen (CAA) detection methods in a Schistosoma mansoni endemic area in northeastern Brazil	9
Ursolic acid induces apoptosis and disrupts host-parasite interactions in Theileria annulata-infected cells	9
Nucleoside analogues for the treatment of animal trypanosomiasis	9
Plasmodium RNA triphosphatase validation as antimalarial target	9
Acaricide resistance status of livestock ticks from East and West Africa and in vivo efficacy of acaricides to control them	8
Reflecting on the past and fast forwarding to present day anthelmintic resistant Ancylostoma caninum–A critical issue we neglected to forecast	8
Efficacy of fenbendazole against gastrointestinal nematodes in naturally infected goats in Maputo Province, Mozambique using in vivo, in vitro and molecular assessment	8
Natural marine products as antiprotozoal agents against amitochondrial parasites	8
Suramin action in African trypanosomes involves a RuvB-like DNA helicase	8
Screening of the activity of sixty essential oils against plasmodium early mosquito stages in vitro and machine learning analysis reveals new putative inhibitors of malaria parasites	8
Egg reappearance periods of anthelmintics against equine cyathostomins: The state of play revisited	8
Effect of urea and squaramide IMPDH inhibitors on C. parvum: in vitro trial design impacts the assessment of drug efficacy	7
Antiplasmodial activity of pentyloxyamide-based histone deacetylase inhibitors against Plasmodium falciparum parasites	7
Structure-activity relationship and target investigation of 2-aryl quinolines with nematocidal activity	7
A graphical user interface for wrmXpress 2.0 streamlines helminth phenotypic screening	7
Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization	7
Inhibitory effect of morin on aldolase 2 from Eimeria tenella	7
Characterization of a P-glycoprotein drug transporter from Toxocara canis with a novel pharmacological profile	7
The effect of sickle cell genotype on the pharmacokinetic properties of artemether-lumefantrine in Tanzanian children	7
Inhibition of Giardia duodenalis by isocryptolepine -triazole adducts and derivatives	6
Repurposing in vitro approaches for screening anti-parasitic drugs against the brain-eating amoeba Naegleria fowleri	6
Robenidine derivatives as potential antischistosomal drug candidates	6

Surveillance of single nucleotide polymorphisms correlated to macrocyclic lactone resistance in Dirofilaria immitis from client-owned dogs across the United States	6
In vitro activity and mechanism of cell death induction of cyanomethyl vinyl ethers derivatives against Trypanosoma cruzi	6
Transcriptional responses to in vitro macrocyclic lactone exposure in Toxocara canis larvae using RNA-seq	6
Profile of molecular markers of Sulfadoxine-Pyrimethamine-resistant Plasmodium falciparum in individuals living in southern area of Brazzaville, Republic of Congo	6
MMV560185 from pathogen box induces extrinsic pathway of apoptosis in Theileria annulata infected bovine leucocytes	6
3-nitroimidazo[1,2-b]pyridazine as a novel scaffold for antiparasitics with sub-nanomolar anti-Giardia lamblia activity	6
Macrocyclic lactones and ectoparasites control in livestock: Efficacy, drug resistance and therapeutic challenges	6
Exploring therapeutic approaches against Naegleria fowleri infections through the COVID box	6
Revisiting anthelmintic resistance in sheep flocks from São Paulo State, Brazil	6
Multiple drug resistance in hookworms infecting greyhound dogs in the USA	6
Ouabain, ATPase inhibitor, potentially enhances the effect of polyhexamethylene biguanide on Acanthamoeba castellanii	6
Multiple anthelmintic drug resistant Ancylostoma caninum in foxhounds	6
Benzaldehyde stimulates autophagy via the sonic hedgehog signaling pathway in mouse brain astrocytes after treatment with Angiostrongylus cantonensis excretory-secretory products	5
A multiplexed high throughput screening assay using flow cytometry identifies glycolytic molecular probes in bloodstream form Trypanosoma brucei	5
Focused review: The role of drug combinations for the control of coccidiosis in commercially reared chickens	5
Drug resistance in animal trypanosomiases: Epidemiology, mechanisms and control strategies	5
Identification and characterization of novel marine oxasqualenoid yucatecone against Naegleria fowleri	5
Exploration of the sensitivity to macrocyclic lactones in the canine heartworm (Dirofilaria immitis) in Australia using phenotypic and genotypic approaches	5
Anti-protozoal activity and metabolomic analyses of Cichorium intybus L. against Trypanosoma cruzi	5
Efficacy of flukicides against Fasciola hepatica and first report of triclabendazole resistance on German sheep farms	5
3′-deoxytubercidin: A potent therapeutic candidate for the treatment of Surra and Dourine	5
Efficacy of the bumped kinase inhibitor BKI-1708 against the cyst-forming apicomplexan parasites Toxoplasma gondii and Neospora caninum in vitro and in experimentally infected mice	4
Rapid detection of mutations in the suspected piperaquine resistance gene E415G-exo in Plasmodium falciparum exonuclease via AS‒PCR and RAA with CRISPR/Cas12a	4
A short-term treatment with BKI-1294 does not protect foetuses from sheep experimentally infected with Neospora caninum tachyzoites during pregnancy	4
Genome-wide analysis of the response to ivermectin treatment by a Swedish field population of Haemonchus contortus	4
Genomic analysis of Indian isolates of Plasmodium falciparum: Implications for drug resistance and virulence factors	4
In vitro screening of the open-access Pandemic Response Box reveals ESI-09 as a compound with activity against Echinococcus multilocularis	4
Evaluation of topotecan and 10-hydroxycamptothecin on Toxoplasma gondii: Implications on baseline DNA damage and repair efficiency	4
Evaluation of the inhibitory efficacy of quaternary ammonium compounds on in vitro growth of Theileria equi parasite in MASP culture	4
Evaluation of the inhibitory effects of emodin on Neospora caninum invasion and proliferation in vitro	3
Lumefantrine attenuates Plasmodium falciparum artemisinin resistance during the early ring stage	3
Comparative structure activity and target exploration of 1,2-diphenylethynes in Haemonchus contortus and Caenorhabditis elegans	3
The phosphatase inhibitor BVT-948 can be used to efficiently screen functional sexual development proteins in the malaria parasite Plasmodium berghei	3
Antimalarial drug resistance and drug discovery: learning from the past to innovate the future	3
Development of a clinical risk scoring system for artesunate treatment failure prediction in malaria patients	3
Genetic diversity in the metronidazole metabolism genes nitroreductases and pyruvate ferredoxin oxidoreductases in susceptible and refractory clinical samples of Giardia lamblia	3
Genetic surveillance for monitoring the impact of drug use on Plasmodium falciparum populations	3
Exploring the β-tubulin gene family in a benzimidazole-resistant Parascaris univalens population	3
In vitro evaluation of Resveratrol as a potential pre-exposure prophylactic drug against Trypanosoma cruzi infection	3
Thieno[3,2-b]pyrrole 5-carboxamides as potent and selective inhibitors of Giardia duodenalis	3
Fighting Plasmodium chloroquine resistance with acetylenic chloroquine analogues	3
Proteomic characterization of Toxoplasma gondii ME49 derived strains resistant to the artemisinin derivatives artemiside and artemisone implies potential mode of action independent of ROS formation	3
Screening and hit evaluation of a microbial metabolite library against the pathogenic Plasmodium falciparum and Toxoplasma gondii parasites	3
Faecal egg count reduction test, deep amplicon sequencing of isotype-1 β-tubulin gene and in ovo larval development assay reveal susceptibility to benzimidazoles of porcine nematodes Oesophagostomum s	3
Evaluation of the in vitro susceptibility of various filarial nematodes to emodepside	3
Selenosugars targeting the infective stage of Trypanosoma brucei with high selectivity	3