OOIR: Observatory of International Research

Papers

(The median citation count of International Journal for Parasitology-Drugs and Drug Resistance is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
In vivo efficiency of praziquantel treatment of single-sex Schistosoma japonicum aged three months old in mice	108
Pharmacokinetic and pharmacodynamic considerations for treating sarcoptic mange with cross-relevance to Australian wildlife	35
Efficacy of the treatment using a microemulsion loaded with epoxy-α-lapachone in combination with meglumine antimoniate against murine infection by Leishmania (Leishmania) amazonensis	33
Forward genetic analysis of monensin and diclazuril resistance in Eimeria tenella	31
Diethylcarbamazine mediated potentiation of emodepside induced paralysis requires TRP-2 in adult Brugia malayi	29
The presence and relative frequency detection of the levamisole-resistance-associated S168T substitution in hco-acr-8 in Haemonchus contortus	28
Anthelmintic resistance in equine nematodes: Current status and emerging trends	27
CRISPR-Cas13b mediated gene knockdowns in Leishmania infantum	27
Investigation of risk factors associated with Ancylostoma spp. infection and the benzimidazole F167Y resistance marker polymorphism in dogs from the United States	25
Comparative transcriptomics of naturally susceptible and resistant Trypanosoma cruzi strains in response to Benznidazole	24
The Haemonchus contortus LGC-39 subunit is a novel subtype of an acetylcholine-gated chloride channel	23
Identification of new drug candidates against Trichomonas gallinae using high-throughput screening	22
Transcriptomic analysis of albendazole resistance in human diarrheal parasite Giardia duodenalis	21
The EamA metabolite transporter does not affect antileishmanial drug susceptibility	20
The faecal egg count reduction test: Will identification of larvae to species improve its utility?	19
Yeast-based assay to identify inhibitors of the malaria parasite sodium phosphate uptake transporter as potential novel antimalarial drugs	18
Pantothenate biosynthesis in Toxoplasma gondii tachyzoites is not a drug target	17
Integrated application of transcriptomics and metabolomics provides insight into the mechanism of Eimeria tenella resistance to maduramycin	17
Recent advances in intestinal helminth parasites of horses in the Asia-Pacific region: Current trends, challenges and future directions	17
The induction and inhibition of UDP-glycosyltransferases in Haemonchus contortus and their role in the metabolism of albendazole	16
A national survey of anthelmintic resistance in ascarid and strongylid nematodes in Australian Thoroughbred horses	16
Novel heterospirocyclic antimalarials with activity against artemisinin- and multidrug-resistant P. falciparum malaria	15
Combining the zebrafish embryo developmental toxicity assay (ZEDTA) with hemoglobin staining to accelerate the research of novel antimalarial drugs for pregnant women	14
Current and emerging target identification methods for novel antimalarials	14
Emergence of Ancylostoma caninum parasites with the benzimidazole resistance F167Y polymorphism in the US dog population	14

Benzimidazole F167Y polymorphism in the canine hookworm, Ancylostoma caninum: Widespread geographic, seasonal, age, and breed distribution in United States and Canada dogs	14
Effects of the G-quadruplex-binding drugs quarfloxin and CX-5461 on the malaria parasite Plasmodium falciparum	14
Mechanistic, in-silico and in vitro studies with nitrofurans reveal potent leishmanicidal activity and inhibition of trypanothione reductase	13
In vitro and in vivo activity evaluation and mode of action of broxaldine on Toxoplasma gondii	13
In artemisinin-resistant falciparum malaria parasites, mitochondrial metabolic pathways are essential for survival but not those of apicoplast	13
Trialling the SmartWorm® application in New Zealand sheep farms	12
Prevalence of antimalarial drug resistance molecular markers in Makenene, central Cameroon	12
Phylogenetic and transcriptomic study of aldo-keto reductases in Haemonchus contortus and their inducibility by flubendazole	12
Thiophene derivatives activity against the protozoan parasite Leishmania infantum	12
Nitroxoline evidence amoebicidal activity against Acanthamoeba castellanii through DNA damage and the stress response pathways	11
Challenges in applying W.A.A.V.P. criteria to diagnosing triclabendazole resistance in Fasciola hepatica, an example from the Southern Tablelands of New South Wales, Australia	11
In vivo efficacy of pyrantel pamoate as a post-exposure prophylactic for rat lungworm (Angiostrongylus cantonensis)	11
Molecular characterization and analysis of drug resistance-associated protein enolase 2 of Eimeria tenella	11
Dual-targeting proteasome inhibitor ONX-0914 demonstrates potent antiplasmodial activity for malaria treatment	10
Anti-malarial activity of HCl salt of SKM13 (SKM13-2HCl)	10
Ursolic acid induces apoptosis and disrupts host-parasite interactions in Theileria annulata-infected cells	10
Therapeutic advantages of the combined use of closantel and moxidectin in lambs parasitized with resistant gastrointestinal nematodes	10
High-throughput prioritization of target proteins for development of new antileishmanial compounds	9
Insights from the use of erythropoietin in experimental Chagas disease	9
Faecal egg count reduction tests and nemabiome analysis reveal high frequency of multi-resistant parasites on sheep farms in north-east Germany involving multiple strongyle parasite species	9
Ribosomal protein L27 contributes to virulence and maduramicin resistance in Eimeria tenella	9
P-glycoproteins and amphids: a two-stage trajectory of ivermectin resistance in Caenorhabditis elegans	9
Quantitative DNA metabarcoding reveals species composition of a macrocyclic lactone and pyrantel resistant cyathostomin population in the UK	9
Evaluating the efficacy of different praziquantel treatment regimens using egg and circulating anodic antigen (CAA) detection methods in a Schistosoma mansoni endemic area in northeastern Brazil	9
Plasmodium RNA triphosphatase validation as antimalarial target	8
Suramin action in African trypanosomes involves a RuvB-like DNA helicase	8
Effect of Phlebotomus papatasi on the fitness, infectivity and antimony-resistance phenotype of antimony-resistant Leishmania major Mon-25	8
Meclonazepam sensitivity of parasitic flatworms correlates with TRPMMCLZ sensitivity to meclonazepam	8
Nucleoside analogues for the treatment of animal trypanosomiasis	8
Reflecting on the past and fast forwarding to present day anthelmintic resistant Ancylostoma caninum–A critical issue we neglected to forecast	8
Efficacy of fenbendazole against gastrointestinal nematodes in naturally infected goats in Maputo Province, Mozambique using in vivo, in vitro and molecular assessment	7
Egg reappearance periods of anthelmintics against equine cyathostomins: The state of play revisited	7
Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization	7
Screening of the activity of sixty essential oils against plasmodium early mosquito stages in vitro and machine learning analysis reveals new putative inhibitors of malaria parasites	7
Natural marine products as antiprotozoal agents against amitochondrial parasites	7
A graphical user interface for wrmXpress 2.0 streamlines helminth phenotypic screening	7
Modified dosing schedule efficacy of fosmidomycin and clindamycin against murine malaria Plasmodium berghei	7
Acaricide resistance status of livestock ticks from East and West Africa and in vivo efficacy of acaricides to control them	7
A practical miracidial motility assay for assessing Fasciola hepatica sensitivity to compounds in vitro	7
The effect of sickle cell genotype on the pharmacokinetic properties of artemether-lumefantrine in Tanzanian children	6
Effect of urea and squaramide IMPDH inhibitors on C. parvum: in vitro trial design impacts the assessment of drug efficacy	6
Structure-activity relationship and target investigation of 2-aryl quinolines with nematocidal activity	6
Transcriptional responses to in vitro macrocyclic lactone exposure in Toxocara canis larvae using RNA-seq	6
Profile of molecular markers of Sulfadoxine-Pyrimethamine-resistant Plasmodium falciparum in individuals living in southern area of Brazzaville, Republic of Congo	6
Antiplasmodial activity of pentyloxyamide-based histone deacetylase inhibitors against Plasmodium falciparum parasites	6
Exploring therapeutic approaches against Naegleria fowleri infections through the COVID box	5
Surveillance of single nucleotide polymorphisms correlated to macrocyclic lactone resistance in Dirofilaria immitis from client-owned dogs across the United States	5
Drug resistance in animal trypanosomiases: Epidemiology, mechanisms and control strategies	5
Revisiting anthelmintic resistance in sheep flocks from São Paulo State, Brazil	5
Inhibitory effect of morin on aldolase 2 from Eimeria tenella	5

In vitro activity and mechanism of cell death induction of cyanomethyl vinyl ethers derivatives against Trypanosoma cruzi	5
Anti-cryptosporidial efficacy of tricyclic carbazole aminoalcohols in vitro and in vivo	5
Inhibition of Giardia duodenalis by isocryptolepine -triazole adducts and derivatives	5
Efficacy of flukicides against Fasciola hepatica and first report of triclabendazole resistance on German sheep farms	5
Ouabain, ATPase inhibitor, potentially enhances the effect of polyhexamethylene biguanide on Acanthamoeba castellanii	4
Macrocyclic lactones and ectoparasites control in livestock: Efficacy, drug resistance and therapeutic challenges	4
Identification and characterization of novel marine oxasqualenoid yucatecone against Naegleria fowleri	4
Evaluation of the inhibitory efficacy of quaternary ammonium compounds on in vitro growth of Theileria equi parasite in MASP culture	4
Multiple anthelmintic drug resistant Ancylostoma caninum in foxhounds	4
Robenidine derivatives as potential antischistosomal drug candidates	4
Pharmacokinetics of fenbendazole and its bioactive metabolite oxfendazole in northern bobwhite administered an anthelmintic feed	4
3′-deoxytubercidin: A potent therapeutic candidate for the treatment of Surra and Dourine	4
Benzaldehyde stimulates autophagy via the sonic hedgehog signaling pathway in mouse brain astrocytes after treatment with Angiostrongylus cantonensis excretory-secretory products	4
3-nitroimidazo[1,2-b]pyridazine as a novel scaffold for antiparasitics with sub-nanomolar anti-Giardia lamblia activity	4
A multiplexed high throughput screening assay using flow cytometry identifies glycolytic molecular probes in bloodstream form Trypanosoma brucei	4
Anti-protozoal activity and metabolomic analyses of Cichorium intybus L. against Trypanosoma cruzi	4
Exploration of the sensitivity to macrocyclic lactones in the canine heartworm (Dirofilaria immitis) in Australia using phenotypic and genotypic approaches	4
Genetic diversity in the metronidazole metabolism genes nitroreductases and pyruvate ferredoxin oxidoreductases in susceptible and refractory clinical samples of Giardia lamblia	3
Screening and hit evaluation of a microbial metabolite library against the pathogenic Plasmodium falciparum and Toxoplasma gondii parasites	3
Genomic analysis of Indian isolates of Plasmodium falciparum: Implications for drug resistance and virulence factors	3
Rapid detection of mutations in the suspected piperaquine resistance gene E415G-exo in Plasmodium falciparum exonuclease via AS‒PCR and RAA with CRISPR/Cas12a	3
Fighting Plasmodium chloroquine resistance with acetylenic chloroquine analogues	3
The first report of macrocyclic lactone resistant cyathostomins in the UK	3
Antimalarial drug resistance and drug discovery: learning from the past to innovate the future	3
Selenosugars targeting the infective stage of Trypanosoma brucei with high selectivity	3
Proteomic characterization of Toxoplasma gondii ME49 derived strains resistant to the artemisinin derivatives artemiside and artemisone implies potential mode of action independent of ROS formation	3
The phosphatase inhibitor BVT-948 can be used to efficiently screen functional sexual development proteins in the malaria parasite Plasmodium berghei	3
Efficacy of the bumped kinase inhibitor BKI-1708 against the cyst-forming apicomplexan parasites Toxoplasma gondii and Neospora caninum in vitro and in experimentally infected mice	3
Faecal egg count reduction test, deep amplicon sequencing of isotype-1 β-tubulin gene and in ovo larval development assay reveal susceptibility to benzimidazoles of porcine nematodes Oesophagostomum s	3
Increased activity of CF3-derivatized levamisole at the ACC-2 receptor from the parasitic nematode Haemonchus contortus	3
Thieno[3,2-b]pyrrole 5-carboxamides as potent and selective inhibitors of Giardia duodenalis	3
Development of a clinical risk scoring system for artesunate treatment failure prediction in malaria patients	3
Comparative structure activity and target exploration of 1,2-diphenylethynes in Haemonchus contortus and Caenorhabditis elegans	3
In vitro screening of the open-access Pandemic Response Box reveals ESI-09 as a compound with activity against Echinococcus multilocularis	3
Evaluation of the inhibitory effects of emodin on Neospora caninum invasion and proliferation in vitro	3
Evaluation of topotecan and 10-hydroxycamptothecin on Toxoplasma gondii: Implications on baseline DNA damage and repair efficiency	3
In vitro antiplasmodial activities of extract and fractions from Lepidobotrys staudtii against sensitive and resistant blood-stage parasites of Plasmodium falciparum	3
Similar patterns of benzimidazole resistance alleles in ovine gastrointestinal nematodes from Western Canada and Eastern United States supports their shared origins and subsequent spread	3
In vitro evaluation of Resveratrol as a potential pre-exposure prophylactic drug against Trypanosoma cruzi infection	3