Cell Reports

Article	Citations
A collection of toolkit strains reveals distinct localization and dynamics of membrane-associated transcripts in epithelia	609
Louder for longer: Myc amplifies gene expression by extended transcriptional bursting	350
Axon targeting of Drosophila medulla projection neurons requires diffusible Netrin and is coordinated with neuroblast temporal patterning	310
LMAN1 is a receptor for house dust mite allergens	265
Neuropeptide signaling and SKN-1 orchestrate differential responses of the proteostasis network to dissimilar proteotoxic insults	214
Ebola virus delta peptide is an enterotoxin	193
A vaccine inducing solely cytotoxic T lymphocytes fully prevents Zika virus infection and fetal damage	192
A spatial map of antennal-expressed ionotropic receptors in the malaria mosquito	188
Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins	182
Rapid presynaptic maturation in naturally regenerating axons of the adult mouse olfactory nerve	178
CpsA mediates infection of recruited lung myeloid cells by Mycobacterium tuberculosis	177
PNKP safeguards stalled replication forks from nuclease-dependent degradation during replication stress	176
Enforced activation of the CREB/KDM2B axis prevents alcohol-induced embryonic developmental delay	174
Spinal microcircuits go through multiphasic homeostatic compensations in a mouse model of motoneuron degeneration	174
PIX is an N-terminal delivery domain that defines a class of polymorphic T6SS effectors in Enterobacterales	172
Sugar detection in 3D: Structure of an insect gustatory receptor	163
Functional organization of posterior parietal cortex circuitry based on inferred information flow	157
SARS-CoV-2 variant of concern fitness and adaptation in primary human airway epithelia	157
CHAMP1 binds to REV7/FANCV and promotes homologous recombination repair	156
Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection	154
Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers	148
Non-degradable autophagic vacuoles are indispensable for cell competition	142
The microbiota and T cells non-genetically modulate inherited phenotypes transgenerationally	141
Attenuating ribosome load improves protein output from mRNA by limiting translation-dependent mRNA decay	138
Peripheral neuronal activation shapes the microbiome and alters gut physiology	134

Efficient data reconstruction: The bottleneck of large-scale application of DNA storage	134
Tissue-colonizing disseminated tumor cells secrete prostaglandin E2 to promote NK cell dysfunction and evade anti-metastatic immunity	133
Q&A with Ilaria Elia	132
A ONECUT1 regulatory, non-coding region in pancreatic development and diabetes	127
High-throughput identification of calcium-regulated proteins across diverse proteomes	126
Complexity of synovial fluid-derived monocyte-macrophage-lineage cells in knee osteoarthritis	123
The absence of telomerase leads to immune response and tumor regression in zebrafish melanoma	123
Sleep deprivation leads to non-adaptive alterations in sleep microarchitecture and amyloid-β accumulation in a murine Alzheimer model	123
Residue Y362 is crucial for FLIPL to impart catalytic activity to pro-caspase-8 to suppress necroptosis	122
Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV	121
Antibodies targeting the shared cytokine receptor IL-1 receptor accessory protein invoke distinct mechanisms to block all cytokine signaling	119
A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism	118
ADA2 is a lysosomal deoxyadenosine deaminase acting on DNA involved in regulating TLR9-mediated immune sensing of DNA	117
Sex-specific expression of distinct serotonin receptors mediates stress vulnerability of adult hippocampal neural stem cells in mice	117
Mis-expression of GATA6 re-programs cell fate during early hematopoiesis	116
TCR-mimicking STAR conveys superior sensitivity over CAR in targeting tumors with low-density neoantigens	116
Latent learning drives sleep-dependent plasticity in distinct CA1 subpopulations	115
Distinct types of intramitochondrial protein aggregates protect mitochondria against proteotoxic stress	115
Legionella uses host Rab GTPases and BAP31 to create a unique ER niche	114
Stereotyped goal-directed manifold dynamics in the insular cortex	113
Defects in CYB5A and CYB5B impact sterol-C4 oxidation in cholesterol biosynthesis and demonstrate regulatory roles of dimethyl sterols	113
CD84 as a therapeutic target for breaking immune tolerance in triple-negative breast cancer	113
Genome-wide characterization of extrachromosomal circular DNA in breast cancer and its potential role in carcinogenesis and cancer progression	110
An IL-2 mutein increases regulatory T cell suppression of dendritic cells via IL-10 and CTLA-4 to promote T cell anergy	109
Generation of circulating autoreactive pre-plasma cells fueled by naive B cells in celiac disease	108
Cancer-associated fibroblasts maintain critical pancreatic cancer cell lipid homeostasis in the tumor microenvironment	106
O-GlcNAcylation modulates expression and abundance of N-glycosylation machinery in an inherited glycosylation disorder	106
Structural basis of ligand specificity and channel activation in an insect gustatory receptor	105
Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids	105
Functionally diverse thymic medullary epithelial cells interplay to direct central tolerance	103
Cardiolipin oxidized by ROS from complex II acts as a target of gasdermin D to drive mitochondrial pore and heart dysfunction in endotoxemia	103
HuR promotes triglyceride synthesis and intestinal fat absorption	103
Behavioral modulations can alter the visual tuning of neurons in the mouse thalamocortical pathway	102
Restricting lysine normalizes toxic catabolites associated with ALDH7A1 deficiency in cells and mice	102
GABAergic amacrine cells balance biased chromatic information in the mouse retina	102
Structural insights into endogenous ligand selectivity and activation mechanisms of FFAR1 and FFAR2	102
Multiplexed single-cell lineage tracing of mitotic kinesin inhibitor resistance in glioblastoma	101
PRMT1 promotes epigenetic reprogramming associated with acquired chemoresistance in pancreatic cancer	100
PD-1 deficiency impairs eosinophil recruitment to tissue during Trichinella spiralis infection	99
Combinatorial genetic engineering strategy for immune protection of stem cell-derived beta cells by chimeric antigen receptor regulatory T cells	99
OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase	98
Carnitine palmitoyltransferase 1 facilitates fatty acid oxidation in a non-cell-autonomous manner	98
The next phase of biomolecular condensate research	98
Angiogenesis in the mature mouse cortex is governed in a regional- and Notch1-dependent manner	97
LKB1 prevents ILC2 exhaustion to enhance antitumor immunity	95
Engineered IscB-ωRNA system with improved base editing efficiency for disease correction via single AAV delivery in mice	95
Individual Atg8 paralogs and a bacterial metabolite sequentially promote hierarchical CASM-xenophagy induction and transition	94
Higher-order thalamocortical circuits are specified by embryonic cortical progenitor types in the mouse brain	92
Memory trace imbalance in reinforcement and punishment systems can reinforce implicit choices leading to obsessive-compulsive behavior	92
FERONIA controls ABA-mediated seed germination via the regulation of CARK1 kinase activity	90

Rebalancing the motor circuit restores movement in a Caenorhabditis elegans model for TDP-43 toxicity	89
PAMless SpRY exhibits a preference for the seed region for efficient targeting	88
Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain	88
Hair cell regeneration, reinnervation, and restoration of hearing thresholds in the avian hearing organ	88
CD36-mediated arachidonic acid influx from decidual stromal cells increases inflammatory macrophages in miscarriage	87
A mitochondrial unfolded protein response-independent role of DVE-1 in longevity regulation	86
Uncovering cell-type-specific immunomodulatory variants and molecular phenotypes in COVID-19 using structurally resolved protein networks	85
TMC7 functions as a suppressor of Piezo2 in primary sensory neurons blunting peripheral mechanotransduction	84
Fibroblast diversification is an embryonic process dependent on muscle contraction	84
cGAS-like receptors drive a systemic STING-dependent host response in Drosophila	84
Vegfc-expressing cells form heterotopic bone after musculoskeletal injury	84
CDK1-PP2A-B55 interplay ensures cell cycle oscillation via Apc1-loop300	82
Q&A with Hao Gu	82
Cytoskeletal activation of NHE1 regulates mechanosensitive cell volume adaptation and proliferation	81
Distinctive physiology of molecularly identified medium spiny neurons in the macaque putamen	81
Regulation of Burkholderia cenocepacia virulence by the fatty acyl-CoA ligase DsfR as a response regulator of quorum sensing signal	81
Netrin1 patterns the dorsal spinal cord through modulation of Bmp signaling	81
Auditory discrimination learning differentially modulates neural representation in auditory cortex subregions and inter-areal connectivity	81
MetA is a “thermal fuse” that inhibits growth and protects Escherichia coli at elevated temperatures	80
The microglial response to inhibition of Colony-stimulating-factor-1 receptor by PLX3397 differs by sex in adult mice	80
Cyclin O controls entry into the cell-cycle variant required for multiciliated cell differentiation	80
Rab11-Rab8 cascade dynamics in primary cilia and membrane tubules	80
Tyzzerella nexilis strains enriched in mobile genetic elements are involved in progressive multiple sclerosis	80
Dissociation-related behaviors in mice emerge from the inhibition of retrosplenial cortex parvalbumin interneurons	79
Interrogation of RNA-bound proteome with XRNAX illuminates molecular alterations in the mouse brain affected with dysmyelination	79
Contextual modulation emerges by integrating feedforward and feedback processing in mouse visual cortex	79
Self-maintenance of zonal hepatocytes during adult homeostasis and their complex plasticity upon distinct liver injuries	79
The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation	79
IMPDH2 dephosphorylation under FGFR signaling promotes S-phase progression and tumor growth	78
Multi-omics reveals immune response and metabolic profiles during high-altitude mountaineering	78
Physiological shedding and C-terminal proteolytic processing of TMEM106B	78
The T cell receptor sequence influences the likelihood of T cell memory formation	78
Ribosome customization and functional diversification among P-stalk proteins regulate late poxvirus protein synthesis	78
Fate erasure logic of gene networks underlying direct neuronal conversion of somatic cells by microRNAs	77
Improved split prime editors enable efficient in vivo genome editing	77
Hydrogen sulfide mediates the interaction between C. elegans and Actinobacteria from its natural microbial environment	76
Dissociable roles of central striatum and anterior lateral motor area in initiating and sustaining naturalistic behavior	76
Motile cilia modulate neuronal and astroglial activity in the zebrafish larval brain	75
A conserved switch to less catalytically active Polycomb repressive complexes in non-dividing cells	75
Santa-maria is a glial phagocytic receptor that acts with SIMU to recognize and engulf apoptotic neurons	75
CPSF1 inhibition promotes widespread use of intergenic polyadenylation sites and impairs glycolysis in prostate cancer cells	75
ERF114/115/109 are essential for jasmonate-repressed non-canonical JAZ8 activity in JA signaling	74
Luminance invariant encoding in mouse primary visual cortex	74
Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy	74
Single cell approaches define neural stem cell niches and identify microglial ligands that can enhance precursor-mediated oligodendrogenesis	74
Coordinated neuron-specific splicing events restrict nucleosome engagement of the LSD1 histone demethylase complex	74
Identification of modulators of the ALT pathway through a native FISH-based optical screen	73
Lack of context modulation in human single neuron responses in the medial temporal lobe	73
Cellular uptake of nickel by NikR is regulated by phase separation	72
Slow AMPA receptors in hippocampal principal cells	72
LRP12 is an endogenous transmembrane inactivator of α4 integrins	72
Beyond body maps: Information content of specific body parts is distributed across the somatosensory homunculus	72
Stn1-Ten1 and Taz1 independently promote replication of subtelomeric fragile sequences in fission yeast	72
GABAergic disinhibition from the BNST to PNOCARC neurons promotes HFD-induced hyperphagia	70
SAYSD1 senses UFMylated ribosome to safeguard co-translational protein translocation at the endoplasmic reticulum	70
Lineage specification in glioblastoma is regulated by METTL7B	70
Sox2 in the dermal papilla regulates hair follicle pigmentation	70
On the origin and evolution of RNA editing in metazoans	70
Large-scale integration of the non-coding RNAs with DNA methylation in human cancers	69
Tracing cell-type evolution by cross-species comparison of cell atlases	69
Chronic type I interferon signaling promotes lipid-peroxidation-driven terminal CD8+ T cell exhaustion and curtails anti-PD-1 efficacy	69
Exploring the pan-cancer landscape of posttranscriptional regulation	68
SMYD3 represses tumor-intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck	68
Prenatal inflammation perturbs murine fetal hematopoietic development and causes persistent changes to postnatal immunity	68
The loss of epithelial Smad4 drives immune evasion via CXCL1 while displaying vulnerability to combinatorial immunotherapy in gastric cancer	68
Regulatory architecture of housekeeping genes is driven by promoter assemblies	68
CD4+ T cells regulate sickness-induced anorexia and fat wasting during a chronic parasitic infection	68
Targeting stromal cell sialylation reverses T cell-mediated immunosuppression in the tumor microenvironment	68
Posttranslational S-nitrosylation modification regulates HMGB1 secretion and promotes its proinflammatory and neurodegenerative effects	67
PDGFRβ+ cells play a dual role as hematopoietic precursors and niche cells during mouse ontogeny	67
SLC15A4 controls endolysosomal TLR7–9 responses by recruiting the innate immune adaptor TASL	67
A non-hallucinogenic LSD analog with therapeutic potential for mood disorders	67
Increased mitochondrial free Ca2+ during ischemia is suppressed, but not eliminated by, germline deletion of the mitochondrial Ca2+ uniporter	67
METTL3-mediated m6A methylation orchestrates mRNA stability and dsRNA contents to equilibrate γδ T1 and γδ T17 cells	67
Dynamic plasticity of prostate cancer intermediate cells during androgen receptor-targeted therapy	67
High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity	66
Constitutive immune activity promotes JNK- and FoxO-dependent remodeling of Drosophila airways	66
Disrupted neural correlates of anesthesia and sleep reveal early circuit dysfunctions in Alzheimer models	66
Structural and functional impact by SARS-CoV-2 Omicron spike mutations	66
NLRP6 in host defense and intestinal inflammation	66

Flattening of circadian glucocorticoid oscillations drives acute hyperinsulinemia and adipocyte hypertrophy	66
Responses and functions of dopamine in nucleus accumbens core during social behaviors	66
Astrocyte-derived small extracellular vesicles promote synapse formation via fibulin-2-mediated TGF-β signaling	66
SRSF3-mediated regulation of N6-methyladenosine modification-related lncRNA ANRIL splicing promotes resistance of pancreatic cancer to gemcitabine	66
Mice hypomorphic for Pitx3 show robust entrainment of circadian behavioral and metabolic rhythms to scheduled feeding	65
Stromal AR inhibits prostate tumor progression by restraining secretory luminal epithelial cells	65
Structural analysis of receptor binding domain mutations in SARS-CoV-2 variants of concern that modulate ACE2 and antibody binding	65
Hepatic ER stress suppresses adipose browning through ATF4-CIRP-ANGPTL3 cascade	65
An additional NF-κB site allows HIV-1 subtype C to evade restriction by nuclear PYHIN proteins	65
Definitive hematopoietic stem cells minimally contribute to embryonic hematopoiesis	65
Transitions in lineage specification and gene regulatory networks in hematopoietic stem/progenitor cells over human development	65
TrkC-CreERT2-mediated recombination supports evidence that TrkC+/TH+ DRG neurons contribute to cardiovascular homeostasis	65
Nuclear transport surveillance of p53 by nuclear pores in glioblastoma	65
Alpha synuclein, the culprit in Parkinson disease, is required for normal immune function	65
Genomic and molecular features distinguish young adult cancer from later-onset cancer	64
Brain erythropoietin fine-tunes a counterbalance between neurodifferentiation and microglia in the adult hippocampus	64
Branchpoint translocation by fork remodelers as a general mechanism of R-loop removal	64
A synaptic molecular dependency network in knockdown of autism- and schizophrenia-associated genes revealed by multiplexed imaging	63
Single-cell transcriptomics of human-skin-equivalent organoids	63
RNA inhibits dMi-2/CHD4 chromatin binding and nucleosome remodeling	63
TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state	63
CXCR3 regulates stem and proliferative CD8+ T cells during chronic infection by promoting interactions with DCs in splenic bridging channels	63
Sites of vulnerability in HCV E1E2 identified by comprehensive functional screening	63
An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein	63
A nickase Cas9 gene-drive system promotes super-Mendelian inheritance in Drosophila	62
A short isoform of STIM1 confers frequency-dependent synaptic enhancement	61
Induction of cyclophilin A by influenza A virus infection facilitates group A Streptococcus coinfection	61
Extensive de novo activity stabilizes epigenetic inheritance of CG methylation in Arabidopsis transposons	60
Zika-specific neutralizing antibodies targeting inter-dimer envelope epitopes	60
Stepwise disassembly of GABAergic synapses during pathogenic excitotoxicity	60
The endocytic pathway taken by cationic substances requires Rab14 but not Rab5 and Rab7	60
UBL7 enhances antiviral innate immunity by promoting Lys27-linked polyubiquitination of MAVS	60
The histone demethylase KDM5 is required for synaptic structure and function at the Drosophila neuromuscular junction	60
Systematic analysis of human antibody response to ebolavirus glycoprotein shows high prevalence of neutralizing public clonotypes	60
Differential effect of sleep deprivation on place cell representations, sleep architecture, and memory in young and old mice	60
PHDs/CPT1B/VDAC1 axis regulates long-chain fatty acid oxidation in cardiomyocytes	60
TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment	59
Aire suppresses CTLA-4 expression from the thymic stroma to control autoimmunity	59
PARylation of BRCA1 limits DNA break resection through BRCA2 and EXO1	59
Dynamics of B cell repertoires and emergence of cross-reactive responses in patients with different severities of COVID-19	59
Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment	59
Functional diversification and dynamics of CAR-T cells in patients with B-ALL	59
A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors	59
Niche-mediated repair of airways is directed in an occupant-dependent manner	58
Balanced T and B cell responses are required for immune protection against Powassan virus in virus-like particle vaccination	58
Transcriptomics, regulatory syntax, and enhancer identification in mesoderm-induced ESCs at single-cell resolution	58
piRNA-guided intron removal from pre-mRNAs regulates density-dependent reproductive strategy	58
Cryo-ET study from in vitro to in vivo revealed a general folding mode of chromatin with two-start helical architecture	58
Assembly and disassembly dynamics of nonmuscle myosin II control endosomal fission	57
Fine-tuning of MEK signaling is pivotal for limiting B and T cell activation	57
Microstimulation of visual area V4 improves visual stimulus detection	57
The endocycle restores tissue tension in the Drosophila abdomen post wound repair	57
Septin barriers protect mammalian host cells against Pseudomonas aeruginosa invasion	57
Failure of digit tip regeneration in the absence of Lmx1b suggests Lmx1b functions disparate from dorsoventral polarity	57
A cholinergic medial septum input to medial habenula mediates generalization formation and extinction of visual aversion	56
Dynamic rearrangement and autophagic degradation of mitochondria during spermiogenesis in the liverwort Marchantia polymorpha	56
Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition	56
Mitochondrial genome recovery by ATFS-1 is essential for development after starvation	56
Transcription factor Ascl2 promotes germinal center B cell responses by directly regulating AID transcription	56
Neuronal activation of Gαq EGL-30/GNAQ late in life rejuvenates cognition across species	56
Maternal γδ T cells shape offspring pulmonary type 2 immunity in a microbiota-dependent manner	56
The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function	55
Tracing colonic embryonic transcriptional profiles and their reactivation upon intestinal damage	55
Wg/Wnt-signaling-induced nuclear translocation of β-catenin is attenuated by a β-catenin peptide through its interference with the IFT-A complex	55
Functional, transcriptional, and microbial shifts associated with healthy pulmonary aging in rhesus macaques	55
ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma	55
Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class	55
Tentonin 3/TMEM150C regulates glucose-stimulated insulin secretion in pancreatic β-cells	55
Dual circuits originating from the ventral hippocampus independently facilitate affective empathy	55
Stimulus information guides the emergence of behavior-related signals in primary somatosensory cortex during learning	54
Interferon-γ induces combined pyroptotic angiopathy and APOL1 expression in human kidney disease	54
An unconventional VH1-2 antibody tolerates escape mutations and shows an antigenic hotspot on SARS-CoV-2 spike	54
Landscape of tumoral ecosystem for enhanced anti-PD-1 immunotherapy by gut Akkermansia muciniphila	54
Accelerated drug-resistant variant discovery with an enhanced, scalable mutagenic base editor platform	54
NR4A1 transcriptionally regulates the differentiation of stem-like CD8+ T cells in the tumor microenvironment	54
CGG repeats in the human FMR1 gene regulate mRNA localization and cellular stress in developing neurons	53
PSD-95 protects synapses from β-amyloid	53
Epigenomic signatures of sarcomatoid differentiation to guide the treatment of renal cell carcinoma	53
TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state	53
Linking phosphoinositide function to mitosis	53
Pain hypersensitivity is dependent on autophagy protein Beclin 1 in males but not females	53
Prospectively defined patterns of APOBEC3A mutagenesis are prevalent in human cancers	53
Phage T3 overcomes the BREX defense through SAM cleavage and inhibition of SAM synthesis by SAM lyase	52
New molecular insights into butterfly pigmentation	52
CdGAP is a talin-binding protein and a target of TGF-β signaling that promotes HER2-positive breast cancer growth and metastasis	52
SLC38A5 aggravates DC-mediated psoriasiform skin inflammation via potentiating lysosomal acidification	52
Atypical B cells and impaired SARS-CoV-2 neutralization following heterologous vaccination in the elderly	52
Awake hippocampal synchronous events are incorporated into offline neuronal reactivation	52
Lower female survival from an opportunistic infection reveals progesterone-driven sex bias in trained immunity	52
CEBPA phase separation links transcriptional activity and 3D chromatin hubs	52
Architectural organization of ∼1,500-neuron modular minicolumnar disinhibitory circuits in healthy and Alzheimer’s cortices	52
Dendritic cell ICAM-1 strengthens synapses with CD8 T cells but is not required for their early differentiation	51
A transcriptomic and proteomic atlas of obesity and type 2 diabetes in cynomolgus monkeys	51
PTEN regulates hematopoietic lineage plasticity via PU.1-dependent chromatin accessibility	51
Correction of amygdalar dysfunction in a rat model of fragile X syndrome	51