Cell Reports

Article	Citations
Q&A with Hao Gu	407
Distinct TAM subset with cross-dressing capability determines the bifurcation of tumor immunity	378
Potentiation of cholinergic and corticofugal inputs to the lateral amygdala in threat learning	275
FTY720 requires vitamin B12-TCN2-CD320 signaling in astrocytes to reduce disease in an animal model of multiple sclerosis	227
Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids	208
Unique potential of immature adult-born neurons for the remodeling of CA3 spatial maps	199
Cellular and subcellular specialization enables biology-constrained deep learning	197
RNA dicing promotes the expression of an oncogenic JAK1 isoform	194
Shear stress-induced Piezo1 activates CD99L2 to facilitate the initiation of blood circulation	168
A trans-kingdom T6SS RNase effector targeting both prokaryotic and host cells for pathogenesis	162
Multimodal CRISPR screens uncover DDX39B as a global repressor of A-to-I RNA editing	162
Mycobacteria trehalose dimycolate interactions with host Mincle remodel blood-brain barrier junctions for brain invasion	160
Macrophage glycine transporter supports IL-1β production by modulating the AKT1/mTOR/NLRP3 pathway	156
Maturation of hippocampus-medial prefrontal cortex projections defines a pathway-specific sensitive period for cognitive flexibility	156
Angiogenesis in the mature mouse cortex is governed in a regional- and Notch1-dependent manner	153
Modification of histidine repeat proteins by inorganic polyphosphate	151
The atypical adhesion GPCR ADGRA1 controls hippocampal inhibitory circuit function	146
Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation	145
SARS-CoV-2 directly infects the inner ear and causes hearing dysfunction	144
Prenatal glucocorticoids exposure disrupts maturation of a cluster of microglia, causing poor social memory and more repetitive behaviors	139
Coordinated expression of retained introns and poison exons in renal cell carcinoma	132
Genome restructuring and lineage diversification of Cryptococcus neoformans during chronic infection of human hosts	130
A cancer-associated METTL14 mutation induces aberrant m6A modification, affecting tumor growth	129
Cytoskeletal activation of NHE1 regulates mechanosensitive cell volume adaptation and proliferation	129
SRSF3-mediated regulation of N6-methyladenosine modification-related lncRNA ANRIL splicing promotes resistance of pancreatic cancer to gemcitabine	128

Motile cilia modulate neuronal and astroglial activity in the zebrafish larval brain	127
Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly	127
Synergistic degradation of circular RNAs by RNAseK and lysosome	125
Chlorophyll biosynthesis under the control of arginine metabolism	124
Optogenetic silencing of medial septal GABAergic neurons disrupts grid cell spatial and temporal coding in the medial entorhinal cortex	124
PFKFB3 activates CAD to enhance de novo pyrimidine synthesis for cell growth	124
Enforced activation of the CREB/KDM2B axis prevents alcohol-induced embryonic developmental delay	123
EWSR1 maintains centromere identity	120
Genome-wide fetalization of enhancer architecture in heart disease	120
Single-cell RNA-seq analysis identifies the atlas of lymph fluid and reveals a sepsis-related T cell subset	119
Organization of Purkinje cell development by neuronal MEGF11 in cerebellar granule cells	116
Gestationally dependent immune organization at the maternal-fetal interface	116
Actin-dependent astrocytic infiltration is a key step for axon defasciculation during remodeling	116
A type III-Dv CRISPR-Cas system is controlled by the transcription factor RpaB and interacts with the DEAD-box RNA helicase CrhR	115
The production of the chemokine CCL2 by corneal sensory neurons initiates anti-viral immunity at the cornea and trigeminal ganglion	114
The medial entorhinal cortex encodes multisensory spatial information	114
From comparative connectomics to large-scale working memory modeling in macaque and marmoset	114
Gasdermin D restricts anti-tumor immunity during PD-L1 checkpoint blockade	114
Deneddylation of ribosomal proteins promotes synergy between MLN4924 and chemotherapy to elicit complete therapeutic responses	111
Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection	110
Tyzzerella nexilis strains enriched in mobile genetic elements are involved in progressive multiple sclerosis	109
SLC38A5 aggravates DC-mediated psoriasiform skin inflammation via potentiating lysosomal acidification	107
Loss of neuronal heterogeneity in epileptogenic human tissue impairs network resilience to sudden changes in synchrony	107
Long-lasting antibody B-cell responses to SARS-CoV-2 three years after the onset of the pandemic	107
TGF-β Determines the Pro-migratory Potential of bFGF Signaling in Medulloblastoma	107
FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stress	105
Direction selectivity of inhibitory interneurons in mouse barrel cortex differs between interneuron subtypes	105
Rigid, bivalent CTLA-4 binding to CD80 is required to disrupt the cis CD80/PD-L1 interaction	104
FABP5 in skin macrophages mediates saturated fat-induced IL-1β signaling in psoriatic inflammation	103
The OsbHLH002/OsICE1-OSH1 module orchestrates secondary cell wall formation in rice	102
Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity	100
Failure of digit tip regeneration in the absence of Lmx1b suggests Lmx1b functions disparate from dorsoventral polarity	100
Pain hypersensitivity is dependent on autophagy protein Beclin 1 in males but not females	99
Durable control of autoimmunity requires sustained stimulation of regulatory T cells	98
Atg15 is a vacuolar phospholipase that disintegrates organelle membranes	98
An unconventional VH1-2 antibody tolerates escape mutations and shows an antigenic hotspot on SARS-CoV-2 spike	97
EZH2 inhibition mitigates HIV immune evasion, reduces reservoir formation, and promotes skewing of CD8+ T cells toward less-exhausted phenotypes	96
Ccl12 coordinates immune-neural crosstalk to promote adipose sympathetic remodeling after burn trauma	94
Scar-associated endothelial-stellate cellular crosstalk drives fibrosis resolution in MASH	94
Extracellular vesicle-mediated trafficking of molecular cues during human brain development	94
Microbial trait of large body size facilitates ecosystem performance	93
Haplotype-resolved genome of hexaploid Solanum nigrum: Insights into origin, evolution, and steroidal glycoalkaloid biosynthesis	93
A neuron subtype-specific role of MEK-ERK signaling in axon survival via transcriptional regulation of Nmnat2	93
Tfam-mediated metabolic perturbation in RORγt+ lymphocytes impacts intestinal tissue homeostasis and promotes GATA3+RORγt+ innate lymphoid cells	93
Regionally defined proteomic profiles of human cerebral tissue and organoids reveal conserved molecular modules of neurodevelopment	92
The histone chaperone ANP32B regulates chromatin incorporation of the atypical human histone variant macroH2A	92
Single cell approaches define neural stem cell niches and identify microglial ligands that can enhance precursor-mediated oligodendrogenesis	92
Fibroblast diversification is an embryonic process dependent on muscle contraction	92
YTHDF2 suppresses the plasmablast genetic program and promotes germinal center formation	92
Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment	92

Retinal glia regulate development of the circadian photoentrainment circuit	91
Intravascular immune surveillance against viremia requires spatiotemporal coordination between Kupffer cells and ILC1s	91
Muscle spindles provide flexible sensory feedback for movement sequences	91
Genetic and chromatin regulation of Pvt1 monoallelic expression	90
Vascular Lamb1 guides the migration of retinal microglial precursors via Itga6-Rac1 signaling	89
Neuropeptide CRH prevents premature differentiation of OPCs following CNS injury and in early postnatal development	89
Cross-species communication via agr controls phage susceptibility in Staphylococcus aureus	89
Epitopes in the capsular polysaccharide and the porin OmpK36 receptors are required for bacteriophage infection of Klebsiella pneumoniae	88
Progenitor-like cells contributing to cellular heterogeneity in the nucleus pulposus are lost in intervertebral disc degeneration	88
SFPQ prevents MDA5-mediated activation of innate immunity and preserves cell viability	87
LKB1 prevents ILC2 exhaustion to enhance antitumor immunity	86
A secondary metabolite of Limosilactobacillus reuteri R2lc drives strain-specific pathology in a spontaneous mouse model of multiple sclerosis	86
HSPA8 dampens SCAP/INSIG split and SREBP activation by reducing PKR-mediated INSIG phosphorylation	86
Accumulation of branched-chain amino acids reprograms glucose metabolism in CD8+ T cells with enhanced effector function and anti-tumor response	86
Mitochondrial fusion and cristae reorganization facilitate acquisition of cardiomyocyte identity during reprogramming of murine fibroblasts	85
Oncogenic Ras activation in permissive somatic cells triggers rapid-onset phenotypic plasticity and elicits a tumor-promoting neutrophil response	84
Energy status orchestrates YTHDF1 phase separation and tumorigenesis	83
Axonal mRNA binding of hnRNP A/B is crucial for axon targeting and maturation of olfactory sensory neurons	83
The balance between IFN-γ and ERK/MAPK signaling activities ensures lifelong maintenance of intestinal stem cells	83
Revisiting the dispersal history of walnut by analyzing the ancient DNA of walnut remains in Xinjiang, China	82
PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA	82
Innate lymphoid cells integrate sensing and plasticity to control fungal infections	81
Connecting dots: Ligand-dependent allostery from protein interaction to gene regulation	81
Periostin deficiency reduces PD-1+ tumor-associated macrophage infiltration and enhances anti-PD-1 efficacy in colorectal cancer	81
Single-cell transcriptome profiling and chromatin accessibility reveal an exhausted regulatory CD4+ T cell subset in systemic lupus erythematosus	80
Engineering of dendritic cell bispecific extracellular vesicles for tumor-targeting immunotherapy	80
A synthetic chlorophagy receptor promotes plant fitness by mediating chloroplast microautophagy	80
EKLF/Klf1 regulates erythroid transcription by its pioneering activity and selective control of RNA Pol II pause-release	79
Defects in CYB5A and CYB5B impact sterol-C4 oxidation in cholesterol biosynthesis and demonstrate regulatory roles of dimethyl sterols	79
Single-cell atlas of craniogenesis uncovers SOXC-dependent, highly proliferative, and myofibroblast-like osteodermal progenitors	79
Q&A with Bin Cao	78
Endophytic mycobiont provides growth benefits via a phenylpropanoid-auxin axis in host plants	78
Intercellular extrachromosomal DNA copy-number heterogeneity drives neuroblastoma cell state diversity	77
The m C methyltransferase NSUN2 promotes progression of acute myeloid leukemia by regulating serine metabolism	77
High plasticity of ribosomal DNA organization in budding yeast	76
Insulin and serine metabolism as sex-specific hallmarks of Alzheimer’s disease in the human hippocampus	75
Neutrophil inflammasomes sense the subcellular delivery route of translocated bacterial effectors and toxins	75
Regulation of RNA localization during oocyte maturation by dynamic RNA-ER association and remodeling of the ER	75
APOE4 drives inflammation in human astrocytes via TAGLN3 repression and NF-κB activation	74
Organization of hippocampal CA3 into correlated cell assemblies supports a stable spatial code	74
METTL3-mediated m6A on nascent RNA coordinates translational and transcriptional programs to activate the NLRP3 inflammasome in macrophages	74
The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression	74
Piezo1 senses hyphae and initiates host defense against pathogenic fungi	74
Structural basis of ligand specificity and channel activation in an insect gustatory receptor	73
The architecture of silk-secreting organs during the final larval stage of silkworms revealed by single-nucleus and spatial transcriptomics	73
Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV	73
Mitochondrial cristae architecture protects against mtDNA release and inflammation	73
The human placenta shapes the phenotype of decidual macrophages	72
A robot-rodent interaction arena with adjustable spatial complexity for ethologically relevant behavioral studies	72
Deep ancestry of Bornean hunter-gatherers supports long-term local ancestry dynamics	72
OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase	72
Association of B cell profile and receptor repertoire with the progression of Alzheimer’s disease	71
Distinct changes to hippocampal and medial entorhinal circuits emerge across the progression of cognitive deficits in epilepsy	71
Auditory discrimination learning differentially modulates neural representation in auditory cortex subregions and inter-areal connectivity	70
Supercoiling-mediated feedback rapidly couples and tunes transcription	70
An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma	69
Secretory IgA in breast milk protects against asthma through modulation of the gut microbiota	69
The CD27/CD70 pathway negatively regulates visceral adipose tissue-resident Th2 cells and controls metabolic homeostasis	69
CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance	69
Chemical-induced epigenome resetting for regeneration program activation in human cells	68
CPSF1 inhibition promotes widespread use of intergenic polyadenylation sites and impairs glycolysis in prostate cancer cells	68
A cell-type-specific alternative splicing regulator shapes synapse properties in a trans-synaptic manner	68
Multi-level functional genomics reveals molecular and cellular oncogenicity of patient-based 3′ untranslated region mutations	68
Cortical mechanisms of visual brightness	68
Santa-maria is a glial phagocytic receptor that acts with SIMU to recognize and engulf apoptotic neurons	68
Jub-induced phosphorylation of Warts inhibits its activity and recruitment into biomolecular condensates	68
Development of pial collaterals by extension of pre-existing artery tips	67
Exploring the pan-cancer landscape of posttranscriptional regulation	67
Identifying genetic determinants of Streptococcus pyogenes-host interactions in a murine intact skin infection model	67
Laminar mechanisms of saccadic suppression in primate visual cortex	67
Modulation of central synapse remodeling after remote peripheral injuries by the CCL2-CCR2 axis and microglia	67
A molecular pathway for cancer cachexia-induced muscle atrophy revealed at single-nucleus resolution	67
PAMless SpRY exhibits a preference for the seed region for efficient targeting	67
The nuclear Argonaute HRDE-1 directs target gene re-localization and shuttles to nuage to promote small RNA-mediated inherited silencing	67
Systematic analysis of human antibody response to ebolavirus glycoprotein shows high prevalence of neutralizing public clonotypes	67
A conserved switch to less catalytically active Polycomb repressive complexes in non-dividing cells	67
Vibrio parahaemolyticus prey targeting requires autoproteolysis-triggered dimerization of the type VI secretion system effector RhsP	67
The absence of telomerase leads to immune response and tumor regression in zebrafish melanoma	67
Sugar-responsive inhibition of Myc-dependent ribosome biogenesis by Clockwork orange	67
DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons	66

Critical roles of the miR-17∼92 family in thymocyte development, leukemogenesis, and autoimmunity	66
Age-independent and targetable transcription factor networks regulating CD8+ T cell senescence in aging humans	66
A synaptic molecular dependency network in knockdown of autism- and schizophrenia-associated genes revealed by multiplexed imaging	66
PIX is an N-terminal delivery domain that defines a class of polymorphic T6SS effectors in Enterobacterales	66
Stereotyped goal-directed manifold dynamics in the insular cortex	65
Memory trace imbalance in reinforcement and punishment systems can reinforce implicit choices leading to obsessive-compulsive behavior	65
An Aurora kinase A-BOD1L1-PP2A B56 axis promotes chromosome segregation fidelity	65
MYB68 regulates radial endodermal differentiation and suberin patterning	65
β1 integrin signaling governs necroptosis via the chromatin-remodeling factor CHD4	65
Neutralization fingerprinting technology for characterizing polyclonal antibody responses to dengue vaccines	65
Food-induced dopamine signaling in AgRP neurons promotes feeding	64
HuR promotes triglyceride synthesis and intestinal fat absorption	64
Chronic hypoxia stabilizes 3βHSD1 via autophagy suppression	64
Single-cell analysis reveals changes in BCG vaccine-injected mice modeling tuberculous meningitis brain infection	64
Sugar detection in 3D: Structure of an insect gustatory receptor	64
Hierarchical behavioral analysis framework as a platform for standardized quantitative identification of behaviors	64
Direct type I interferon signaling in hepatocytes controls malaria	64
Cell context-dependent CFI-1/ARID3 functions control neuronal terminal differentiation	64
MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis	64
Prenatal inflammation perturbs murine fetal hematopoietic development and causes persistent changes to postnatal immunity	63
Very-long-chain fatty acids are crucial to neuronal polarity by providing sphingolipids to lipid rafts	63
Gamma synchronization between the medial temporal lobe and medial frontal cortex for goal-directed visual attention in humans	63
The T cell receptor sequence influences the likelihood of T cell memory formation	63
PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle	62
53BP1 interacts with the RNA primer from Okazaki fragments to support their processing during unperturbed DNA replication	62
PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model	62
CD84 as a therapeutic target for breaking immune tolerance in triple-negative breast cancer	62
A vascular-associated fibroblastic cell controls pancreatic islet immunity	62
Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo	62
CD4+ T cells regulate sickness-induced anorexia and fat wasting during a chronic parasitic infection	62
Compartmentalized PGRP expression along the dipteran Bactrocera dorsalis gut forms a zone of protection for symbiotic bacteria	62
Multimode neural population coding of diverse innate fear response by mitral and tufted cells	61
Multi-omic profiling reveals the ataxia protein sacsin is required for integrin trafficking and synaptic organization	61
C9ORF72 poly-PR induces TDP-43 nuclear condensation via NEAT1 and is modulated by HSP70 activity	61
Amino acids in cancer: Understanding metabolic plasticity and divergence for better therapeutic approaches	61
miRNA-mediated inhibition of an actomyosin network in hippocampal pyramidal neurons restricts sociability in adult male mice	61
MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC	61
Mechanistic insight into the induction of liver tissue-resident memory CD8+ T cells by glycolipid-peptide vaccination	60
Stress-induced glucocorticoid desensitizes adrenoreceptors to gate the neuroendocrine response to somatic stress in male mice	60
CRISPR screening identifies PRMT1 as a key pro-ferroptotic gene via a two-layer regulatory mechanism	60
The Chlamydia effector IncE employs two short linear motifs to reprogram host vesicle trafficking	60
TRPV6 channel mediates alcohol-induced gut barrier dysfunction and systemic response	60
The cellular basis of mechanosensation in mammalian tongue	60
Compromised nonsense-mediated RNA decay results in truncated RNA-binding protein production upon DUX4 expression	60
Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia	60
A ribosome-bound tRNA half stimulates mitochondrial translation during stress recovery in Trypanosoma brucei	59
Organelle interactions compartmentalize hepatic fatty acid trafficking and metabolism	59
Identification of the viral and cellular microRNA interactomes during SARS-CoV-2 infection	59
Dynamic chromatin remodeling in cycling human endometrium at single-cell level	59
Gcn5- and Bre1-mediated Set2 degradation promotes chronological aging of Saccharomyces cerevisiae	59
Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer’s disease risk gene SORL1	59
Bodies in motion: Unraveling the distinct roles of motion and shape in dynamic body responses in the temporal cortex	59
Loss of the proton-activated chloride channel in neurons impairs AMPA receptor endocytosis and LTD via endosomal hyper-acidification	59
Genome-wide Survey of Ribosome Collision	58
Midbrain dopamine neurons signal phasic and ramping reward prediction error during goal-directed navigation	58
SETDB1 promotes mammalian liver regeneration by stimulating cytokine CSF3 in hepatocytes	58
RTEL1 and MCM10 overcome topological stress during vertebrate replication termination	58
METTL3 regulates cartilage development and homeostasis by affecting Lats1 mRNA stability in an m6A-YTHDF2-dependent manner	58
Randomly barcoded transposon mutant libraries for gut commensals II: Applying libraries for functional genetics	57
Active APPL1 sequestration by Plasmodium favors liver-stage development	57
The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels	57
Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes	57
The soil microbiome modulates the sorghum root metabolome and cellular traits with a concomitant reduction of Striga infection	57
Acute neuroinflammation leads to disruption of neuronal chloride regulation and consequent hyperexcitability in the dentate gyrus	57
Arid1a mutation suppresses TGF-β signaling and induces cholangiocarcinoma	57
The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER	57
NKp44/HLA-DP-dependent regulation of CD8 effector T cells by NK cells	57
Laminar and dorsoventral organization of layer 1 interneuronal microcircuitry in superficial layers of the medial entorhinal cortex	56
Functional genome-wide short hairpin RNA library screening identifies key molecules for extracellular vesicle secretion from microglia	56
Redefining sensorimotor mismatch selectivity in the visual cortex	56
Structural insights into ligand recognition, selectivity, and activation of bombesin receptor subtype-3	56
Stromal cell and B cell dialogue potentiates IL-33-enriched lymphoid niches to support eosinophil recruitment and function during type 2 immunity	56
Separation-of-function mutants reveal the NF-κB-independent involvement of IκBα in the regulation of intestinal stemness	55
CD169+ macrophages identify and eliminate tumor cells in colorectal cancer through CD169/CD43 interaction and FasL-driven apoptosis	55
Bone marrow monocytes sustain NK cell-poiesis during non-alcoholic steatohepatitis	55
Documenting the diversity of the Namibian Ju|’hoansi intestinal microbiome	55
Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages	55
Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination	55
Cd99l2 regulates excitatory synapse development and restrains immediate-early gene activation	55
EPH receptor tyrosine kinases phosphorylate the PAR-3 scaffold protein to modulate downstream signaling networks	54
The predatory soil bacterium Myxococcus xanthus combines a Tad- and an atypical type 3-like protein secretion system to kill bacterial cells	54
Chromatin modification abnormalities by CHD7 and KMT2C loss promote medulloblastoma progression	54
Gene-regulatory programs that specify age-related differences during thymocyte development	54
S1 represents multisensory contexts and somatotopic locations within and outside the bounds of the cortical homunculus	54
Mammalian milk glycomes: Connecting the dots between evolutionary conservation and biosynthetic pathways	54
T-type Ca2+ and persistent Na+ currents synergistically elevate ventral, not dorsal, entorhinal cortical stellate cell excitability	54
Histone acetyltransferase HAF2 associates with pyruvate dehydrogenase complex to control H3K14ac and H3K23ac in ethylene response	54
Deep repertoire mining uncovers ultra-broad coronavirus neutralizing antibodies targeting multiple spike epitopes	54
A LATS2 and ALKBH5 positive feedback loop supports their oncogenic roles	54
Bordetella spp. block eosinophil recruitment to suppress the generation of early mucosal protection	54
Septo-subicular cholinergic circuit promotes seizure development via astrocytic inflammation	54
Poly-ubiquitylated transmembrane proteins outcompete other cargo for limited space inside clathrin-coated vesicles	53
Metabolite-dependent m6A methylation driven by mechanotransduction-metabolism-epitranscriptomics axis promotes bone development and regeneration	53
Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4+ T cell immunity	53
ERK activation dynamics in maturing oocyte controls embryonic nuclear divisions in Caenorhabditis elegans	53