Drug Delivery and Translational Research

Article	Citations
Intranasal drug delivery: opportunities and toxicologic challenges during drug development	245
Enhancement strategies for transdermal drug delivery systems: current trends and applications	208
Current hurdles to the translation of nanomedicines from bench to the clinic	119
Current approaches in lipid-based nanocarriers for oral drug delivery	102
Ultrasound-responsive polymer-based drug delivery systems	89
Clinical approval of nanotechnology-based SARS-CoV-2 mRNA vaccines: impact on translational nanomedicine	80
Influencing factors and drug application of iontophoresis in transdermal drug delivery: an overview of recent progress	73
Therapy of infected wounds: overcoming clinical challenges by advanced drug delivery systems	72
Polymeric micelles and cancer therapy: an ingenious multimodal tumor-targeted drug delivery system	70
Exosomal targeting and its potential clinical application	70
Cell membrane-coated nanoparticles: a novel multifunctional biomimetic drug delivery system	62
Clinical translation of gold nanoparticles	62
Development of vaccine formulations: past, present, and future	52
Recent advances in porous microneedles: materials, fabrication, and transdermal applications	51
An overview of chitosan and its application in infectious diseases	51
Robotics, microfluidics, nanotechnology and AI in the synthesis and evaluation of liposomes and polymeric drug delivery systems	49
A robotic pill for oral delivery of biotherapeutics: safety, tolerability, and performance in healthy subjects	47
Intranasal drug delivery for treatment of Alzheimer’s disease	44
Exploring the role of mesoporous silica nanoparticle in the development of novel drug delivery systems	41
Nanoparticle-mediated pulmonary drug delivery: state of the art towards efficient treatment of recalcitrant respiratory tract bacterial infections	41
Nanotechnology-based approaches applied to nutraceuticals	39
Soluplus® polymeric nanomicelles improve solubility of BCS-class II drugs	38
Nanoemulsion-based dissolving microneedle arrays for enhanced intradermal and transdermal delivery	38
Microneedle-based insulin transdermal delivery system: current status and translation challenges	36
Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies	35

Inflammation-responsive delivery systems for the treatment of chronic inflammatory diseases	35
Titanium dioxide nanotubes as drug carriers for infection control and osteogenesis of bone implants	35
Exosomes as cell-derivative carriers in the diagnosis and treatment of central nervous system diseases	34
Gastro-retentive drug delivery systems: a recent update on clinical pertinence and drug delivery	33
Improving dexamethasone drug loading and efficacy in treating arthritis through a lipophilic prodrug entrapped into PLGA-PEG nanoparticles	32
Advances in 4D printing: from stimulation to simulation	32
Direct cyclodextrin-based powder extrusion 3D printing for one-step production of the BCS class II model drug niclosamide	32
Dermatokinetic assessment of luliconazole-loaded nanostructured lipid carriers (NLCs) for topical delivery: QbD-driven design, optimization, and in vitro and ex vivo evaluations	32
Rapidly dissolving microneedle patch of amphotericin B for intracorneal fungal infections	31
Transdermal drug delivery systems for fighting common viral infectious diseases	31
Nano-fats for bugs: the benefits of lipid nanoparticles for antimicrobial therapy	31
Microfluidic chip connected to porous microneedle array for continuous ISF sampling	31
Inhaled antibodies: formulations require specific development to overcome instability due to nebulization	29
Development and approval of rybelsus (oral semaglutide): ushering in a new era in peptide delivery	29
Transferrin-modified chitosan nanoparticles for targeted nose-to-brain delivery of proteins	29
Antimicrobial nanomedicine for ocular bacterial and fungal infection	29
Preparation and characterization of 3D printed PLA microneedle arrays for prolonged transdermal drug delivery of estradiol valerate	28
Advances in microneedle-based transdermal delivery for drugs and peptides	28
A novel method for fabrication of coated microneedles with homogeneous and controllable drug dosage for transdermal drug delivery	28
Nanocomposite systems for precise oral delivery of drugs and biologics	28
Natural polysaccharide-based biodegradable polymeric platforms for transdermal drug delivery system: a critical analysis	28
The combination of nanotechnology and traditional Chinese medicine (TCM) inspires the modernization of TCM: review on nanotechnology in TCM-based drug delivery systems	28
In vitro dissolution testing models of ocular implants for posterior segment drug delivery	27
A review on multivesicular liposomes for pharmaceutical applications: preparation, characterization, and translational challenges	26
Besifloxacin-loaded ocular nanoemulsions: design, formulation and efficacy evaluation	26
Nanocarriers for cancer nano-immunotherapy	26
Non-dermal applications of microneedle drug delivery systems	26
The exosome: a review of current therapeutic roles and capabilities in human reproduction	26
Advances in vaccine delivery systems against viral infectious diseases	25
Lipid-based emulsion drug delivery systems — a comprehensive review	25
Role of drug delivery technologies in the success of COVID-19 vaccines: a perspective	24
Three-dimensional (3D) liver cell models - a tool for bridging the gap between animal studies and clinical trials when screening liver accumulation and toxicity of nanobiomaterials	24
Mesenchymal stem cells’ seeded amniotic membrane as a tissue-engineered dressing for wound healing	23
Formulation and evaluation of transdermal nanogel for delivery of artemether	23
3D bioprinted scaffolds for diabetic wound-healing applications	23
Recent advances in nanocarriers for nutrient delivery	23
Simvastatin-loaded nano-niosomes confer cardioprotection against myocardial ischemia/reperfusion injury	23
Synergistic and receptor-mediated targeting of arthritic joints via intra-articular injectable smart hydrogels containing leflunomide-loaded lipid nanocarriers	23
Ovalbumin and cholera toxin delivery to buccal mucus for immunization using microneedles and comparison of immunological response to transmucosal delivery	23
Transdermal delivery for gene therapy	22
Intelligent automated drug administration and therapy: future of healthcare	22
Pulmonary delivery of osimertinib liposomes for non-small cell lung cancer treatment: formulation development and in vitro evaluation	22
γ-Cyclodextrin metal–organic framework as a carrier to deliver triptolide for the treatment of hepatocellular carcinoma	22
Characterization of commercial PLGAs by NMR spectroscopy	22
Formulation and optimization of microsponge-loaded emulgel to improve the transdermal application of acyclovir—a DOE based approach	22
Quality by design (QbD)–based fabrication of atazanavir-loaded nanostructured lipid carriers for lymph targeting: bioavailability enhancement using chylomicron flow block model and toxicity studies	22
Using nanotechnology to deliver biomolecules from nose to brain — peptides, proteins, monoclonal antibodies and RNA	22
Extracellular vesicle–based drug delivery in cancer immunotherapy	22
Role of three-dimensional cell culture in therapeutics and diagnostics: an updated review	21
Nanomedicines in the treatment of colon cancer: a focus on metallodrugs	21

Spray-dried lactose-leucine microparticles for pulmonary delivery of antimycobacterial nanopharmaceuticals	21
Design and development of insulin microneedles for diabetes treatment	21
Enzyme-responsive smart nanocarriers for targeted chemotherapy: an overview	21
Biosynthesis of gold nanoparticles using leaf extract of Dittrichia viscosa and in vivo assessment of its anti-diabetic efficacy	21
Thermosensitive and mucoadhesive hydrogel containing curcumin-loaded lipid-core nanocapsules coated with chitosan for the treatment of oral squamous cell carcinoma	21
Investigating hesperetin nanocrystals with tailor-made sizes for the prevention and treatment of Alzheimer’s disease	21
Engineering biomaterials to prevent post-operative infection and fibrosis	21
A chitosan-based nanosystem as pneumococcal vaccine delivery platform	21
SPION and doxorubicin-loaded polymeric nanocarriers for glioblastoma theranostics	21
Gellan gum–based in situ gelling ophthalmic nanosuspension of Posaconazole	21
Effect of surfactant concentration and sterilization process on intraocular pressure–lowering activity of Δ9-tetrahydrocannabinol-valine-hemisuccinate (NB1111) nanoemulsions	20
Testing of aerosolized ciprofloxacin nanocarriers on cystic fibrosis airway cells infected with P. aeruginosa biofilms	20
Long-acting injectable PLGA/PLA depots for leuprolide acetate: successful translation from bench to clinic	20
Engineering of 2D nanomaterials to trap and kill SARS-CoV-2: a new insight from multi-microsecond atomistic simulations	20
Asymmetric flow field-flow fractionation as a multifunctional technique for the characterization of polymeric nanocarriers	19
In vitro release, ex vivo penetration, and in vivo dermatokinetics of ketoconazole-loaded solid lipid nanoparticles for topical delivery	19
Mannose-conjugated chitosan nanoparticles for delivery of Rifampicin to Osteoarticular tuberculosis	19
Co-delivery of cisplatin and siRNA through hybrid nanocarrier platform for masking resistance to chemotherapy in lung cancer	19
Topographical nanostructures for physical sterilization	19
Recent advances in the delivery and applications of nonviral CRISPR/Cas9 gene editing	19
Irinotecan and berberine co-delivery liposomes showed improved efficacy and reduced intestinal toxicity compared with Onivyde for pancreatic cancer	19
Nanotechnology advances in pathogen- and host-targeted antiviral delivery: multipronged therapeutic intervention for pandemic control	19
Manufacturing readiness assessment for evaluation of the microneedle array patch industry: an exploration of barriers to full-scale manufacturing	19
Repurposing drug molecules for new pulmonary therapeutic interventions	19
Current status and future of delivery systems for prevention and treatment of infections in the oral cavity	19
Bone regeneration in osteoporosis: opportunities and challenges	18
Molecular hybridization combining tumor homing and penetrating peptide domains for cellular targeting	18
Enhancement of oral bioavailability and anti-hyperuricemic activity of aloe emodin via novel Soluplus®—glycyrrhizic acid mixed micelle system	18
Exploring paclitaxel-loaded adenosine-conjugated PEGylated PLGA nanoparticles for targeting triple-negative breast cancer	18
Targeting fibroblast activation protein (FAP): advances in CAR-T cell, antibody, and vaccine in cancer immunotherapy	18
Development of a novel nanoemulgel formulation containing cumin essential oil as skin permeation enhancer	18
Curcumin, a potent therapeutic nutraceutical and its enhanced delivery and bioaccessibility by pickering emulsions	18
Development of a novel rapamycin loaded nano- into micro-formulation for treatment of lung inflammation	18
Posaconazole micelles for ocular delivery: in vitro permeation, ocular irritation and antifungal activity studies	17
Hydroxycamptothecin (HCPT)-loaded PEGlated lipid–polymer hybrid nanoparticles for effective delivery of HCPT: QbD-based development and evaluation	17
A triple combination 'nano' dry powder inhaler for tuberculosis: in vitro and in vivo pulmonary characterization	17
Mucosal and transdermal vaccine delivery strategies against COVID-19	17
Overcoming delivery barriers in immunotherapy for glioblastoma	17
Carboxymethyl-β-glucan/chitosan nanoparticles: new thermostable and efficient carriers for antigen delivery	17
Light-responsive biomaterials for ocular drug delivery	16
A nanoemulsion/micelles mixed nanosystem for the oral administration of hydrophobically modified insulin	16
Technological advances in the use of viral and non-viral vectors for delivering genetic and non-genetic cargos for cancer therapy	16
Controlled release of pharmaceutical agents using eutectic modified gelatin	15
Pharmaceutical design of a delivery system for the bacteriocin lacticin 3147	15
An expanding horizon of complex injectable products: development and regulatory considerations	15
Microemulsion systems: from the design and architecture to the building of a new delivery system for multiple-route drug delivery	15
Surface-engineered nanostructured lipid carrier systems for synergistic combination oncotherapy of non-small cell lung cancer	15
Predicting topical drug clearance from the skin	15
Overcoming biological barriers to improve solid tumor immunotherapy	15
Nanotherapeutics in autophagy: a paradigm shift in cancer treatment	15
Dissolving microneedle rollers for rapid transdermal drug delivery	15
Rapidly dissolving bilayer microneedles enabling minimally invasive and efficient protein delivery to the posterior segment of the eye	15
Bioavailability enhancement of vitamin E TPGS liposomes of nintedanib esylate: formulation optimization, cytotoxicity and pharmacokinetic studies	15
Synthesis and evaluation of wound healing properties of hydro-diab hydrogel loaded with green-synthetized AGNPS: in vitro and in ex vivo studies	15
From the laboratory to the end-user: a primary packaging study for microneedle patches containing amoxicillin sodium	14
The promise of microneedle technologies for drug delivery	14
Dermal delivery and follicular targeting of adapalene using PAMAM dendrimers	14
Transdermal delivery of a somatostatin receptor type 2 antagonist using microneedle patch technology for hypoglycemia prevention	14
Targeted nano-delivery of chemotherapy via intranasal route suppresses in vivo glioblastoma growth and prolongs survival in the intracranial mouse model	14
Internalizing RGD, a great motif for targeted peptide and protein delivery: a review article	14
Osteointegration, antimicrobial and antibiofilm activity of orthopaedic titanium surfaces coated with silver and strontium-doped hydroxyapatite using a novel blasting process	14
In vitro degradation and erosion behavior of commercial PLGAs used for controlled drug delivery	14
Enhancing the function of PLGA-collagen scaffold by incorporating TGF-β1-loaded PLGA-PEG-PLGA nanoparticles for cartilage tissue engineering using human dental pulp stem cells	14
Fabrication of microneedle patches with lyophilized influenza vaccine suspended in organic solvent	14
Exploring chitosan-shelled nanobubbles to improve HER2 + immunotherapy via dendritic cell targeting	14
A sustained release cysteamine microsphere/thermoresponsive gel eyedrop for corneal cystinosis improves drug stability	14
Pulmonary drug delivery: an effective and convenient delivery route to combat COVID-19	14
A comparative biodistribution study of polymeric and lipid-based nanoparticles	14
Fused deposition modeling three-dimensional printing of flexible polyurethane intravaginal rings with controlled tunable release profiles for multiple active drugs	13
Molecular perspective of efficiency and safety problems of chemical enhancers: bottlenecks and recent advances	13
Modelling acute myeloid leukemia (AML): What’s new? A transition from the classical to the modern	13
Are lipid nanoparticles really superior? A holistic proof of concept study	13
Should local drug delivery systems be used in dentistry?	13
Nanotechnology-based cell-mediated delivery systems for cancer therapy and diagnosis	13
Design, analysis and fabrication of solid polymer microneedle patch using CO2 laser and polymer molding	13
Local administration of submicron particle paclitaxel to solid carcinomas induces direct cytotoxicity and immune-mediated tumoricidal effects without local or systemic toxicity: preclinical and clinic	13
Nanomedicine in therapeutic warfront against estrogen receptor–positive breast cancer	13
Quercetin-biapigenin nanoparticles are effective to penetrate the blood–brain barrier	13
Tailoring drug co-delivery nanosystem for mitigating U-87 stem cells drug resistance	13
Nanoclays for wound management applications	12

Interlaboratory evaluation of a digital holographic microscopy–based assay for label-free in vitro cytotoxicity testing of polymeric nanocarriers	12
Regulatory safety evaluation of nanomedical products: key issues to refine	12
Microimaging of a novel intracochlear drug delivery device in combination with cochlear implants in the human inner ear	12
Standardization of an in vitro assay matrix to assess cytotoxicity of organic nanocarriers: a pilot interlaboratory comparison	12
Future perspectives for advancing regulatory science of nanotechnology-enabled health products	12
Nanomedicine-based combination of dexamethasone palmitate and MCL-1 siRNA for synergistic therapeutic efficacy against rheumatoid arthritis	12
A hypotonic gel-forming eye drop provides enhanced intraocular delivery of a kinase inhibitor with melanin-binding properties for sustained protection of retinal ganglion cells	12
Polymeric magnetic nanoparticles: a multitargeting approach for brain tumour therapy and imaging	12
Enhanced oral bioavailability and antitumor therapeutic efficacy of sorafenib administered in core–shell protein nanoparticle	12
Shape-specific microfabricated particles for biomedical applications: a review	12
Evaluating nanobiomaterial-induced DNA strand breaks using the alkaline comet assay	12
Critical parameters for design and development of multivalent nanoconstructs: recent trends	12
Short-chain fatty acid-mediated epigenetic modulation of inflammatory T cells in vitro	12
Delivery strategies for cell-based therapies in the brain: overcoming multiple barriers	12
Topical and transdermal delivery with diseased human skin: passive and iontophoretic delivery of hydrocortisone into psoriatic and eczematous skin	12
Alginate-pectin microparticles loaded with nanoemulsions as nanocomposites for wound healing	12
Co-delivery systems: hope for clinical application?	12
Drug delivery methods for cancer immunotherapy	12
Hydrogel composite containing azelaic acid and tea tree essential oil as a therapeutic strategy for Propionibacterium and testosterone-induced acne	11
Co-delivery of glial cell–derived neurotrophic factor (GDNF) and tauroursodeoxycholic acid (TUDCA) from PLGA microspheres: potential combination therapy for retinal diseases	11
Biomedical applications of electrospun nanofibers in the management of diabetic wounds	11
Preparation, characterization, and in vivo evaluation of levonorgestrel-loaded thermostable microneedles	11
Design and development of topical liposomal formulations in a regulatory perspective	11
Thiolated polymer nanocarrier reinforced with glycyrrhetinic acid for targeted delivery of 5-fluorouracil in hepatocellular carcinoma	11
Boronates as hydrogen peroxide–reactive warheads in the design of detection probes, prodrugs, and nanomedicines used in tumors and other diseases	11
Cell-based carrier for targeted hitchhiking delivery	11
Tailor-made oligonucleotide-loaded lipid-polymer nanosystems designed for bone gene therapy	11
Statistical optimization of voriconazole nanoparticles loaded carboxymethyl chitosan-poloxamer based in situ gel for ocular delivery: In vitro, ex vivo, and toxicity assessment	11
Topical delivery of salicylates	11
An update on microneedle-based systems for diabetes	11
Milk-derived exosomes carrying siRNA-KEAP1 promote diabetic wound healing by improving oxidative stress	11
Recent progress of macrophage vesicle-based drug delivery systems	11
Nanoformulations of flavonoids for diabetes and microvascular diabetic complications	11
Nanotechnological approaches for pentamidine delivery	11
Single domain antibody-based vectors in the delivery of biologics across the blood–brain barrier: a review	11
Glycerosomal thermosensitive in situ gel of duloxetine HCl as a novel nanoplatform for rectal delivery: in vitro optimization and in vivo appraisal	11
Nicaraven-loaded electrospun wound dressings promote diabetic wound healing via proangiogenic and immunomodulatory functions: a preclinical investigation	11
Preparation and evaluation of antibacterial wound dressing based on vancomycin-loaded silk/dialdehyde starch nanoparticles	11
Nanomedicines and nanocarriers in clinical trials: surfing through regulatory requirements and physico-chemical critical quality attributes	11
Rational combination of an immune checkpoint inhibitor with CSF1R inhibitor–loaded nanoparticle enhances anticancer efficacy	11
In vivo evaluation of nanostructured lipid carrier systems (NLCs) in mice bearing prostate cancer tumours	11
Chitosan-based drug delivery systems for skin atopic dermatitis: recent advancements and patent trends	10
Self-luminescent photodynamic therapy and pathogen detection for infectious diseases	10
Ameliorative effect of rubiadin-loaded nanocarriers in STZ-NA-induced diabetic nephropathy in rats: formulation optimization, molecular docking, and in vivo biological evaluation	10
New perspectives on the topical management of recurrent candidiasis	10
Targeting the extracellular matrix for immunomodulation: applications in drug delivery and cell therapies	10
Biomaterial-based immunotherapeutic strategies for rheumatoid arthritis	10
Delivery of transcription factors as modulators of cell differentiation	10
MAP-box: a novel, low-cost and easy-to-fabricate 3D-printed box for the storage and transportation of dissolving microneedle array patches	10
Adventitial injection of HA/SA hydrogel loaded with PLGA rapamycin nanoparticle inhibits neointimal hyperplasia in a rat aortic wire injury model	10
Engineered versus hybrid cellular vesicles as efficient drug delivery systems: a comparative study with brain targeted vesicles	10
Liposome-polyethylenimine complexes for the effective delivery of HuR siRNA in the treatment of diabetic retinopathy	10
RETRACTED ARTICLE: Co-delivery of doxorubicin and SIS3 by folate-targeted polymeric micelles for overcoming tumor multidrug resistance	10
Mesenchymal stem cells are prospective novel off-the-shelf wound management tools	10
Fucoidan, a brown seaweed polysaccharide in nanodrug delivery	10
Cationic liposomes as promising vehicles for timolol/brimonidine combination ocular delivery in glaucoma: formulation development and in vitro/in vivo evaluation	10
Biomaterial-enabled induction of pancreatic-specific regulatory T cells through distinct signal transduction pathways	9
Ocular barriers as a double-edged sword: preventing and facilitating drug delivery to the retina	9
Fabrication and characterization of bilayer scaffolds made of decellularized dermis/nanofibrous collagen for healing of full-thickness wounds	9
Development of ritonavir-loaded nanostructured lipid carriers employing quality by design (QbD) as a tool: characterizations, permeability, and bioavailability studies	9
Neutrophils and neutrophil extracellular traps in cancer: promising targets for engineered nanomaterials	9
Liquid antisolvent crystallization of pharmaceutical compounds: current status and future perspectives	9
Vincristine-based nanoformulations: a preclinical and clinical studies overview	9
Mannose-modified hyaluronic acid nanocapsules for the targeting of tumor-associated macrophages	9
Drug delivery nanosystems targeted to hepatic ischemia and reperfusion injury	9
A multistep in vitro hemocompatibility testing protocol recapitulating the foreign body reaction to nanocarriers	9
Polymeric micelles with anti-virulence activity against Candida albicans in a single- and dual-species biofilm	9
Self-assembled polyelectrolyte complexes of chitosan and fucoidan for sustained growth factor release from PRP enhance proliferation and collagen deposition in diabetic mice	9
Nanostructured lipid carriers of isradipine for effective management of hypertension and isoproterenol induced myocardial infarction	9
Preparation and evaluation of rapid disintegrating formulation from coated microneedle	9
Combination of micelles and liposomes as a promising drug delivery system: a review	9
Development of andrographolide-loaded solid lipid nanoparticles for lymphatic targeting: Formulation, optimization, characterization, in vitro, and in vivo evaluation	9
Fabrication of pure-drug microneedles for delivery of montelukast sodium	9
Microneedle-mediated treatment for superficial tumors by combining multiple strategies	9
Exploration of novel drug delivery systems in topical management of osteoarthritis	9
Magnetically responsive nanoplatform targeting circRNA circ_0058051 inhibits hepatocellular carcinoma progression	9
Inulin-lipid hybrid (ILH) microparticles promote pH-triggered release of rifampicin within infected macrophages	9
Tobramycin-loaded complexes to prevent and disrupt Pseudomonas aeruginosa biofilms	9
Nano-based drug delivery system: a smart alternative towards eradication of viral sanctuaries in management of NeuroAIDS	9