Drug Delivery and Translational Research

Papers
(The median citation count of Drug Delivery and Translational Research is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)
ArticleCitations
Intranasal drug delivery: opportunities and toxicologic challenges during drug development245
Enhancement strategies for transdermal drug delivery systems: current trends and applications208
Current hurdles to the translation of nanomedicines from bench to the clinic119
Current approaches in lipid-based nanocarriers for oral drug delivery102
Ultrasound-responsive polymer-based drug delivery systems89
Clinical approval of nanotechnology-based SARS-CoV-2 mRNA vaccines: impact on translational nanomedicine80
Influencing factors and drug application of iontophoresis in transdermal drug delivery: an overview of recent progress73
Therapy of infected wounds: overcoming clinical challenges by advanced drug delivery systems72
Exosomal targeting and its potential clinical application70
Polymeric micelles and cancer therapy: an ingenious multimodal tumor-targeted drug delivery system70
Clinical translation of gold nanoparticles62
Cell membrane-coated nanoparticles: a novel multifunctional biomimetic drug delivery system62
Development of vaccine formulations: past, present, and future52
An overview of chitosan and its application in infectious diseases51
Recent advances in porous microneedles: materials, fabrication, and transdermal applications51
Robotics, microfluidics, nanotechnology and AI in the synthesis and evaluation of liposomes and polymeric drug delivery systems49
A robotic pill for oral delivery of biotherapeutics: safety, tolerability, and performance in healthy subjects47
Intranasal drug delivery for treatment of Alzheimer’s disease44
Nanoparticle-mediated pulmonary drug delivery: state of the art towards efficient treatment of recalcitrant respiratory tract bacterial infections41
Exploring the role of mesoporous silica nanoparticle in the development of novel drug delivery systems41
Nanotechnology-based approaches applied to nutraceuticals39
Nanoemulsion-based dissolving microneedle arrays for enhanced intradermal and transdermal delivery38
Soluplus® polymeric nanomicelles improve solubility of BCS-class II drugs38
Microneedle-based insulin transdermal delivery system: current status and translation challenges36
Inflammation-responsive delivery systems for the treatment of chronic inflammatory diseases35
Titanium dioxide nanotubes as drug carriers for infection control and osteogenesis of bone implants35
Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies35
Exosomes as cell-derivative carriers in the diagnosis and treatment of central nervous system diseases34
Gastro-retentive drug delivery systems: a recent update on clinical pertinence and drug delivery33
Advances in 4D printing: from stimulation to simulation32
Direct cyclodextrin-based powder extrusion 3D printing for one-step production of the BCS class II model drug niclosamide32
Dermatokinetic assessment of luliconazole-loaded nanostructured lipid carriers (NLCs) for topical delivery: QbD-driven design, optimization, and in vitro and ex vivo evaluations32
Improving dexamethasone drug loading and efficacy in treating arthritis through a lipophilic prodrug entrapped into PLGA-PEG nanoparticles32
Transdermal drug delivery systems for fighting common viral infectious diseases31
Nano-fats for bugs: the benefits of lipid nanoparticles for antimicrobial therapy31
Microfluidic chip connected to porous microneedle array for continuous ISF sampling31
Rapidly dissolving microneedle patch of amphotericin B for intracorneal fungal infections31
Transferrin-modified chitosan nanoparticles for targeted nose-to-brain delivery of proteins29
Antimicrobial nanomedicine for ocular bacterial and fungal infection29
Inhaled antibodies: formulations require specific development to overcome instability due to nebulization29
Development and approval of rybelsus (oral semaglutide): ushering in a new era in peptide delivery29
A novel method for fabrication of coated microneedles with homogeneous and controllable drug dosage for transdermal drug delivery28
Nanocomposite systems for precise oral delivery of drugs and biologics28
Natural polysaccharide-based biodegradable polymeric platforms for transdermal drug delivery system: a critical analysis28
The combination of nanotechnology and traditional Chinese medicine (TCM) inspires the modernization of TCM: review on nanotechnology in TCM-based drug delivery systems28
Preparation and characterization of 3D printed PLA microneedle arrays for prolonged transdermal drug delivery of estradiol valerate28
Advances in microneedle-based transdermal delivery for drugs and peptides28
In vitro dissolution testing models of ocular implants for posterior segment drug delivery27
Non-dermal applications of microneedle drug delivery systems26
The exosome: a review of current therapeutic roles and capabilities in human reproduction26
A review on multivesicular liposomes for pharmaceutical applications: preparation, characterization, and translational challenges26
Besifloxacin-loaded ocular nanoemulsions: design, formulation and efficacy evaluation26
Nanocarriers for cancer nano-immunotherapy26
Lipid-based emulsion drug delivery systems — a comprehensive review25
Advances in vaccine delivery systems against viral infectious diseases25
Role of drug delivery technologies in the success of COVID-19 vaccines: a perspective24
Three-dimensional (3D) liver cell models - a tool for bridging the gap between animal studies and clinical trials when screening liver accumulation and toxicity of nanobiomaterials24
Recent advances in nanocarriers for nutrient delivery23
Simvastatin-loaded nano-niosomes confer cardioprotection against myocardial ischemia/reperfusion injury23
Synergistic and receptor-mediated targeting of arthritic joints via intra-articular injectable smart hydrogels containing leflunomide-loaded lipid nanocarriers23
Ovalbumin and cholera toxin delivery to buccal mucus for immunization using microneedles and comparison of immunological response to transmucosal delivery23
Mesenchymal stem cells’ seeded amniotic membrane as a tissue-engineered dressing for wound healing23
Formulation and evaluation of transdermal nanogel for delivery of artemether23
3D bioprinted scaffolds for diabetic wound-healing applications23
γ-Cyclodextrin metal–organic framework as a carrier to deliver triptolide for the treatment of hepatocellular carcinoma22
Characterization of commercial PLGAs by NMR spectroscopy22
Formulation and optimization of microsponge-loaded emulgel to improve the transdermal application of acyclovir—a DOE based approach22
Quality by design (QbD)–based fabrication of atazanavir-loaded nanostructured lipid carriers for lymph targeting: bioavailability enhancement using chylomicron flow block model and toxicity studies22
Using nanotechnology to deliver biomolecules from nose to brain — peptides, proteins, monoclonal antibodies and RNA22
Extracellular vesicle–based drug delivery in cancer immunotherapy22
Transdermal delivery for gene therapy22
Intelligent automated drug administration and therapy: future of healthcare22
Pulmonary delivery of osimertinib liposomes for non-small cell lung cancer treatment: formulation development and in vitro evaluation22
Biosynthesis of gold nanoparticles using leaf extract of Dittrichia viscosa and in vivo assessment of its anti-diabetic efficacy21
Thermosensitive and mucoadhesive hydrogel containing curcumin-loaded lipid-core nanocapsules coated with chitosan for the treatment of oral squamous cell carcinoma21
Investigating hesperetin nanocrystals with tailor-made sizes for the prevention and treatment of Alzheimer’s disease21
Engineering biomaterials to prevent post-operative infection and fibrosis21
A chitosan-based nanosystem as pneumococcal vaccine delivery platform21
SPION and doxorubicin-loaded polymeric nanocarriers for glioblastoma theranostics21
Gellan gum–based in situ gelling ophthalmic nanosuspension of Posaconazole21
Role of three-dimensional cell culture in therapeutics and diagnostics: an updated review21
Nanomedicines in the treatment of colon cancer: a focus on metallodrugs21
Spray-dried lactose-leucine microparticles for pulmonary delivery of antimycobacterial nanopharmaceuticals21
Design and development of insulin microneedles for diabetes treatment21
Enzyme-responsive smart nanocarriers for targeted chemotherapy: an overview21
Testing of aerosolized ciprofloxacin nanocarriers on cystic fibrosis airway cells infected with P. aeruginosa biofilms20
Long-acting injectable PLGA/PLA depots for leuprolide acetate: successful translation from bench to clinic20
Engineering of 2D nanomaterials to trap and kill SARS-CoV-2: a new insight from multi-microsecond atomistic simulations20
Effect of surfactant concentration and sterilization process on intraocular pressure–lowering activity of Δ9-tetrahydrocannabinol-valine-hemisuccinate (NB1111) nanoemulsions20
Topographical nanostructures for physical sterilization19
Recent advances in the delivery and applications of nonviral CRISPR/Cas9 gene editing19
Irinotecan and berberine co-delivery liposomes showed improved efficacy and reduced intestinal toxicity compared with Onivyde for pancreatic cancer19
Nanotechnology advances in pathogen- and host-targeted antiviral delivery: multipronged therapeutic intervention for pandemic control19
Manufacturing readiness assessment for evaluation of the microneedle array patch industry: an exploration of barriers to full-scale manufacturing19
Repurposing drug molecules for new pulmonary therapeutic interventions19
Current status and future of delivery systems for prevention and treatment of infections in the oral cavity19
Asymmetric flow field-flow fractionation as a multifunctional technique for the characterization of polymeric nanocarriers19
In vitro release, ex vivo penetration, and in vivo dermatokinetics of ketoconazole-loaded solid lipid nanoparticles for topical delivery19
Mannose-conjugated chitosan nanoparticles for delivery of Rifampicin to Osteoarticular tuberculosis19
Co-delivery of cisplatin and siRNA through hybrid nanocarrier platform for masking resistance to chemotherapy in lung cancer19
Targeting fibroblast activation protein (FAP): advances in CAR-T cell, antibody, and vaccine in cancer immunotherapy18
Development of a novel nanoemulgel formulation containing cumin essential oil as skin permeation enhancer18
Curcumin, a potent therapeutic nutraceutical and its enhanced delivery and bioaccessibility by pickering emulsions18
Development of a novel rapamycin loaded nano- into micro-formulation for treatment of lung inflammation18
Bone regeneration in osteoporosis: opportunities and challenges18
Molecular hybridization combining tumor homing and penetrating peptide domains for cellular targeting18
Enhancement of oral bioavailability and anti-hyperuricemic activity of aloe emodin via novel Soluplus®—glycyrrhizic acid mixed micelle system18
Exploring paclitaxel-loaded adenosine-conjugated PEGylated PLGA nanoparticles for targeting triple-negative breast cancer18
A triple combination 'nano' dry powder inhaler for tuberculosis: in vitro and in vivo pulmonary characterization17
Mucosal and transdermal vaccine delivery strategies against COVID-1917
Overcoming delivery barriers in immunotherapy for glioblastoma17
Carboxymethyl-β-glucan/chitosan nanoparticles: new thermostable and efficient carriers for antigen delivery17
Posaconazole micelles for ocular delivery: in vitro permeation, ocular irritation and antifungal activity studies17
Hydroxycamptothecin (HCPT)-loaded PEGlated lipid–polymer hybrid nanoparticles for effective delivery of HCPT: QbD-based development and evaluation17
A nanoemulsion/micelles mixed nanosystem for the oral administration of hydrophobically modified insulin16
Technological advances in the use of viral and non-viral vectors for delivering genetic and non-genetic cargos for cancer therapy16
Light-responsive biomaterials for ocular drug delivery16
Surface-engineered nanostructured lipid carrier systems for synergistic combination oncotherapy of non-small cell lung cancer15
Predicting topical drug clearance from the skin15
Overcoming biological barriers to improve solid tumor immunotherapy15
Nanotherapeutics in autophagy: a paradigm shift in cancer treatment15
Dissolving microneedle rollers for rapid transdermal drug delivery15
Rapidly dissolving bilayer microneedles enabling minimally invasive and efficient protein delivery to the posterior segment of the eye15
Bioavailability enhancement of vitamin E TPGS liposomes of nintedanib esylate: formulation optimization, cytotoxicity and pharmacokinetic studies15
Synthesis and evaluation of wound healing properties of hydro-diab hydrogel loaded with green-synthetized AGNPS: in vitro and in ex vivo studies15
Controlled release of pharmaceutical agents using eutectic modified gelatin15
Pharmaceutical design of a delivery system for the bacteriocin lacticin 314715
An expanding horizon of complex injectable products: development and regulatory considerations15
Microemulsion systems: from the design and architecture to the building of a new delivery system for multiple-route drug delivery15
Osteointegration, antimicrobial and antibiofilm activity of orthopaedic titanium surfaces coated with silver and strontium-doped hydroxyapatite using a novel blasting process14
In vitro degradation and erosion behavior of commercial PLGAs used for controlled drug delivery14
Enhancing the function of PLGA-collagen scaffold by incorporating TGF-β1-loaded PLGA-PEG-PLGA nanoparticles for cartilage tissue engineering using human dental pulp stem cells14
Fabrication of microneedle patches with lyophilized influenza vaccine suspended in organic solvent14
Exploring chitosan-shelled nanobubbles to improve HER2 + immunotherapy via dendritic cell targeting14
A sustained release cysteamine microsphere/thermoresponsive gel eyedrop for corneal cystinosis improves drug stability14
Pulmonary drug delivery: an effective and convenient delivery route to combat COVID-1914
A comparative biodistribution study of polymeric and lipid-based nanoparticles14
From the laboratory to the end-user: a primary packaging study for microneedle patches containing amoxicillin sodium14
The promise of microneedle technologies for drug delivery14
Dermal delivery and follicular targeting of adapalene using PAMAM dendrimers14
Transdermal delivery of a somatostatin receptor type 2 antagonist using microneedle patch technology for hypoglycemia prevention14
Targeted nano-delivery of chemotherapy via intranasal route suppresses in vivo glioblastoma growth and prolongs survival in the intracranial mouse model14
Internalizing RGD, a great motif for targeted peptide and protein delivery: a review article14
Are lipid nanoparticles really superior? A holistic proof of concept study13
Should local drug delivery systems be used in dentistry?13
Nanotechnology-based cell-mediated delivery systems for cancer therapy and diagnosis13
Design, analysis and fabrication of solid polymer microneedle patch using CO2 laser and polymer molding13
Local administration of submicron particle paclitaxel to solid carcinomas induces direct cytotoxicity and immune-mediated tumoricidal effects without local or systemic toxicity: preclinical and clinic13
Nanomedicine in therapeutic warfront against estrogen receptor–positive breast cancer13
Quercetin-biapigenin nanoparticles are effective to penetrate the blood–brain barrier13
Tailoring drug co-delivery nanosystem for mitigating U-87 stem cells drug resistance13
Fused deposition modeling three-dimensional printing of flexible polyurethane intravaginal rings with controlled tunable release profiles for multiple active drugs13
Molecular perspective of efficiency and safety problems of chemical enhancers: bottlenecks and recent advances13
Modelling acute myeloid leukemia (AML): What’s new? A transition from the classical to the modern13
Polymeric magnetic nanoparticles: a multitargeting approach for brain tumour therapy and imaging12
Enhanced oral bioavailability and antitumor therapeutic efficacy of sorafenib administered in core–shell protein nanoparticle12
Shape-specific microfabricated particles for biomedical applications: a review12
Evaluating nanobiomaterial-induced DNA strand breaks using the alkaline comet assay12
Critical parameters for design and development of multivalent nanoconstructs: recent trends12
Short-chain fatty acid-mediated epigenetic modulation of inflammatory T cells in vitro12
Delivery strategies for cell-based therapies in the brain: overcoming multiple barriers12
Topical and transdermal delivery with diseased human skin: passive and iontophoretic delivery of hydrocortisone into psoriatic and eczematous skin12
Alginate-pectin microparticles loaded with nanoemulsions as nanocomposites for wound healing12
Co-delivery systems: hope for clinical application?12
Drug delivery methods for cancer immunotherapy12
Nanoclays for wound management applications12
Interlaboratory evaluation of a digital holographic microscopy–based assay for label-free in vitro cytotoxicity testing of polymeric nanocarriers12
Regulatory safety evaluation of nanomedical products: key issues to refine12
Microimaging of a novel intracochlear drug delivery device in combination with cochlear implants in the human inner ear12
Standardization of an in vitro assay matrix to assess cytotoxicity of organic nanocarriers: a pilot interlaboratory comparison12
Future perspectives for advancing regulatory science of nanotechnology-enabled health products12
Nanomedicine-based combination of dexamethasone palmitate and MCL-1 siRNA for synergistic therapeutic efficacy against rheumatoid arthritis12
A hypotonic gel-forming eye drop provides enhanced intraocular delivery of a kinase inhibitor with melanin-binding properties for sustained protection of retinal ganglion cells12
Rational combination of an immune checkpoint inhibitor with CSF1R inhibitor–loaded nanoparticle enhances anticancer efficacy11
In vivo evaluation of nanostructured lipid carrier systems (NLCs) in mice bearing prostate cancer tumours11
Hydrogel composite containing azelaic acid and tea tree essential oil as a therapeutic strategy for Propionibacterium and testosterone-induced acne11
Co-delivery of glial cell–derived neurotrophic factor (GDNF) and tauroursodeoxycholic acid (TUDCA) from PLGA microspheres: potential combination therapy for retinal diseases11
Milk-derived exosomes carrying siRNA-KEAP1 promote diabetic wound healing by improving oxidative stress11
Biomedical applications of electrospun nanofibers in the management of diabetic wounds11
Preparation, characterization, and in vivo evaluation of levonorgestrel-loaded thermostable microneedles11
Thiolated polymer nanocarrier reinforced with glycyrrhetinic acid for targeted delivery of 5-fluorouracil in hepatocellular carcinoma11
Boronates as hydrogen peroxide–reactive warheads in the design of detection probes, prodrugs, and nanomedicines used in tumors and other diseases11
Cell-based carrier for targeted hitchhiking delivery11
Tailor-made oligonucleotide-loaded lipid-polymer nanosystems designed for bone gene therapy11
Nanomedicines and nanocarriers in clinical trials: surfing through regulatory requirements and physico-chemical critical quality attributes11
Statistical optimization of voriconazole nanoparticles loaded carboxymethyl chitosan-poloxamer based in situ gel for ocular delivery: In vitro, ex vivo, and toxicity assessment11
Topical delivery of salicylates11
An update on microneedle-based systems for diabetes11
Recent progress of macrophage vesicle-based drug delivery systems11
Nanoformulations of flavonoids for diabetes and microvascular diabetic complications11
Nanotechnological approaches for pentamidine delivery11
Single domain antibody-based vectors in the delivery of biologics across the blood–brain barrier: a review11
Design and development of topical liposomal formulations in a regulatory perspective11
Glycerosomal thermosensitive in situ gel of duloxetine HCl as a novel nanoplatform for rectal delivery: in vitro optimization and in vivo appraisal11
Nicaraven-loaded electrospun wound dressings promote diabetic wound healing via proangiogenic and immunomodulatory functions: a preclinical investigation11
Preparation and evaluation of antibacterial wound dressing based on vancomycin-loaded silk/dialdehyde starch nanoparticles11
Chitosan-based drug delivery systems for skin atopic dermatitis: recent advancements and patent trends10
Self-luminescent photodynamic therapy and pathogen detection for infectious diseases10
Ameliorative effect of rubiadin-loaded nanocarriers in STZ-NA-induced diabetic nephropathy in rats: formulation optimization, molecular docking, and in vivo biological evaluation10
New perspectives on the topical management of recurrent candidiasis10
Targeting the extracellular matrix for immunomodulation: applications in drug delivery and cell therapies10
Biomaterial-based immunotherapeutic strategies for rheumatoid arthritis10
Delivery of transcription factors as modulators of cell differentiation10
MAP-box: a novel, low-cost and easy-to-fabricate 3D-printed box for the storage and transportation of dissolving microneedle array patches10
Adventitial injection of HA/SA hydrogel loaded with PLGA rapamycin nanoparticle inhibits neointimal hyperplasia in a rat aortic wire injury model10
Engineered versus hybrid cellular vesicles as efficient drug delivery systems: a comparative study with brain targeted vesicles10
Liposome-polyethylenimine complexes for the effective delivery of HuR siRNA in the treatment of diabetic retinopathy10
RETRACTED ARTICLE: Co-delivery of doxorubicin and SIS3 by folate-targeted polymeric micelles for overcoming tumor multidrug resistance10
Mesenchymal stem cells are prospective novel off-the-shelf wound management tools10
Fucoidan, a brown seaweed polysaccharide in nanodrug delivery10
Cationic liposomes as promising vehicles for timolol/brimonidine combination ocular delivery in glaucoma: formulation development and in vitro/in vivo evaluation10
Tobramycin-loaded complexes to prevent and disrupt Pseudomonas aeruginosa biofilms9
Nano-based drug delivery system: a smart alternative towards eradication of viral sanctuaries in management of NeuroAIDS9
Biomaterial-enabled induction of pancreatic-specific regulatory T cells through distinct signal transduction pathways9
Ocular barriers as a double-edged sword: preventing and facilitating drug delivery to the retina9
Fabrication and characterization of bilayer scaffolds made of decellularized dermis/nanofibrous collagen for healing of full-thickness wounds9
Development of ritonavir-loaded nanostructured lipid carriers employing quality by design (QbD) as a tool: characterizations, permeability, and bioavailability studies9
Neutrophils and neutrophil extracellular traps in cancer: promising targets for engineered nanomaterials9
Liquid antisolvent crystallization of pharmaceutical compounds: current status and future perspectives9
Vincristine-based nanoformulations: a preclinical and clinical studies overview9
Mannose-modified hyaluronic acid nanocapsules for the targeting of tumor-associated macrophages9
Drug delivery nanosystems targeted to hepatic ischemia and reperfusion injury9
A multistep in vitro hemocompatibility testing protocol recapitulating the foreign body reaction to nanocarriers9
Polymeric micelles with anti-virulence activity against Candida albicans in a single- and dual-species biofilm9
Self-assembled polyelectrolyte complexes of chitosan and fucoidan for sustained growth factor release from PRP enhance proliferation and collagen deposition in diabetic mice9
Nanostructured lipid carriers of isradipine for effective management of hypertension and isoproterenol induced myocardial infarction9
Preparation and evaluation of rapid disintegrating formulation from coated microneedle9
Combination of micelles and liposomes as a promising drug delivery system: a review9
Development of andrographolide-loaded solid lipid nanoparticles for lymphatic targeting: Formulation, optimization, characterization, in vitro, and in vivo evaluation9
Fabrication of pure-drug microneedles for delivery of montelukast sodium9
Microneedle-mediated treatment for superficial tumors by combining multiple strategies9
Exploration of novel drug delivery systems in topical management of osteoarthritis9
Magnetically responsive nanoplatform targeting circRNA circ_0058051 inhibits hepatocellular carcinoma progression9
Inulin-lipid hybrid (ILH) microparticles promote pH-triggered release of rifampicin within infected macrophages9
Nanomaterials for antigen-specific immune tolerance therapy8
QbD enabled optimization of solvent shifting method for fabrication of PLGA-based nanoparticles for promising delivery of Capecitabine for antitumor activity8
Zein-based nanocarriers for the oral delivery of insulin. In vivo evaluation in Caenorhabditis elegans8
Baicalin-berberine complex nanocrystals orally promote the co-absorption of two components8
3-O-Methylquercetin from Achyrocline satureioides—cytotoxic activity against A375-derived human melanoma cell lines and its incorporation into cyclodextrins-hydrogels for topical administration8
An individualized digital twin of a patient for transdermal fentanyl therapy for chronic pain management8
Ashwagandha-loaded nanocapsules improved the behavioral alterations, and blocked MAPK and induced Nrf2 signaling pathways in a hepatic encephalopathy rat model8
Harnessing nanomedicine for enhanced immunotherapy for breast cancer brain metastases8
Computational modeling of intraocular drug delivery supplied by porous implants8
Efficacy of topical Miltefosine formulations in an experimental model of cutaneous leishmaniasis8
Quantitation of lymphatic transport mechanism and barrier influences on lymph node-resident leukocyte access to lymph-borne macromolecules and drug delivery systems8
Chemical imaging analysis of active pharmaceutical ingredient in dissolving microneedle arrays by Raman spectroscopy8
Phenytoin-loaded bioactive nanoparticles for the treatment of diabetic pressure ulcers: formulation and in vitro/in vivo evaluation8
Enhanced biopharmaceutical performance of brick dust molecule nilotinib via stabilized amorphous nanosuspension using a facile acid–base neutralization approach8
Anticancer and chemosensitization effects of cannabidiol in 2D and 3D cultures of TNBC: involvement of GADD45α, integrin-α5, -β5, -β1, and autophagy8
Better and greener: sustainable pharmaceutical manufacturing technologies for highly bioavailable solid dosage forms8
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