OOIR: Observatory of International Research

Papers

(The TQCC of Oncoimmunology is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Short-term immune-checkpoint inhibition partially rescues perturbed bone marrow hematopoiesis in mismatch-repair deficient tumors	131
Longitudinal immune monitoring of patients with resectable esophageal adenocarcinoma treated with Neoadjuvant PD-L1 checkpoint inhibition	116
Listeria-based vaccination against the pericyte antigen RGS5 elicits anti-vascular effects and colon cancer protection	89
Immune checkpoint blockade improves the activation and function of circulating mucosal-associated invariant T (MAIT) cells in patients with non-small cell lung cancer	85
MicroRNA analysis of Natural Killer cell-derived exosomes: the microRNA let-7b-5p is enriched in exosomes and participates in their anti-tumor effects against pancreatic cancer cells	83
Targeting 3D chromosomal architecture at the RANK loci to suppress myeloma-driven osteoclastogenesis	78
Non-small cell lung cancer patients treated with Anti-PD1 immunotherapy show distinct microbial signatures and metabolic pathways according to progression-free survival and PD-L1 status	71
Ferroptosis: friend or foe in cancer immunotherapy?	56
Novel strategies for the mitigation of cytokine release syndrome induced by T cell engaging therapies with a focus on the use of kinase inhibitors	56
In vitro generated macrophages reflect the immunosuppressive phenotype of in vivo glioblastoma-associated macrophages	55
Loss of the extracellular protease ADAMTS1 reveals an antitumorigenic program involving the action of NIDOGEN-1 on macrophage polarization	55
Mild microwave hyperthermia promotes mitotic catastrophe, induces time-delayed cGAS-STING activation and restores sensitivity to anti-PDL1 therapy in Pan02 pancreatic cancer model	54
The endoplasmic reticulum chaperone BiP: a target for immunogenic cell death inducers?	54
Correction	51
IRE1α overexpression in malignant cells limits tumor progression by inducing an anti-cancer immune response	51
Tertiary lymphoid structures in desmoplastic melanoma have increased lymphocyte density, lymphocyte proliferation, and immune cross talk with tumor when compared to non-desmoplastic melanomas	49
CPT1C-positive cancer-associated fibroblast facilitates immunosuppression through promoting IL-6-induced M2-like phenotype of macrophage	48
The anti-inflammatory cytokine IL-37 improves the NK cell-mediated anti-tumor response	47
STING is significantly increased in high-grade glioma with high risk of recurrence	44
A novel Fc-enhanced humanized monoclonal antibody targeting B7-H3 suppresses the growth of ESCC	41
PB101, a VEGF- and PlGF-targeting decoy protein, enhances antitumor immunity and suppresses tumor progression and metastasis	41
Light on life: immunoscore immune-checkpoint, a predictor of immunotherapy response	41
LTX-315 and adoptive cell therapy using tumor-infiltrating lymphocytes generate tumor specific T cells in patients with metastatic soft tissue sarcoma	41
Intracavitary adoptive transfer of IL-12 mRNA-engineered tumor-specific CD8 ⁺ T cells eradicates peritoneal metastases in mouse models	37
Urinary T cells are detected in patients with immune checkpoint inhibitor-associated immune nephritis that are clonotypically identical to kidney T cell infiltrates	36

Radiotherapy-induced abscopal effects in immune checkpoint inhibitor-refractory metastatic disease: results from a large multicenter real-world cohort study	36
PD-1 is expressed in cytotoxic granules of NK cells and rapidly mobilized to the cell membrane following recognition of tumor cells	35
CXCL10 and IL15 co-expressing chimeric antigen receptor T cells enhance anti-tumor effects in gastric cancer by increasing cytotoxic effector cell accumulation and survival	35
Noninvasive radiomic biomarkers for predicting pseudoprogression and hyperprogression in patients with non-small cell lung cancer treated with immune checkpoint inhibition	35
KRAS-elicited PDIA6 blocks PERK-dependent immunogenic cell death in pancreatic carcinoma	34
Enhancement of tumor immunogenicity by the introduction of non- proteinogenic amino acid azetidine-2-carboxylic acid	34
Avelumab induces greater Fc-Fc receptor-dependent natural killer cell activation and dendritic cell crosstalk compared to durvalumab	34
Multidimensional immune profiling uncovers biphasic peripheral T-cell dynamics after chemoradiation in patients with locally advanced head and neck cancer	33
Targeting the activin receptor 1C on CD4+ T cells for cancer immunotherapy	32
Lactate/GPR81 recruits regulatory T cells by modulating CX3CL1 to promote immune resistance in a highly glycolytic gastric cancer	32
Improving STING agonist-based cancer therapy by inhibiting the autophagy-related protein VPS34	31
Markers of tumor-associated macrophages and microglia exhibit high intratumoral heterogeneity in human glioblastoma tissue	31
Unlocking the therapeutic potential of immuno-radiotherapy: insights from preclinical and clinical research	31
Interferon regulatory factor 4 plays a pivotal role in the development of aGVHD-associated colitis	30
Novel immunotheranostic FAP-inhibitor target modules for imaging and elimination of FAP-positive cells by UniCAR T-cells	30
Preclinical evaluation of chimeric antigen receptor T cells targeting the carcinoembryonic antigen as a potential immunotherapy for gallbladder cancer	29
Cell therapy for a rare disease- hairy cell leukemia variant	28
Immune cell clustering identifies a CD163⁺/CSF1R⁺ macrophage and neutrophil-enriched phenotype with distinct biological signatures and poor prognosis in angiosarcoma	28
SIGLEC15, negatively correlated with PD-L1 in HCC, could induce CD8+ T cell apoptosis to promote immune evasion	28
Safety and effectiveness of combination versus monotherapy with immune checkpoint inhibitors in patients with preexisting autoimmune diseases	28
Neoadjuvant immune checkpoint blockade triggers persistent and systemic T _reg activation which blunts therapeutic efficacy against metastatic spread	28
Targeting DNA damage response components induces enhanced STING-dependent type-I IFN response in ATM deficient cancer cells and drives dendritic cell activation	28
Chemokine switch regulated by TGF-β1 in cancer-associated fibroblast subsets determines the efficacy of chemo-immunotherapy	27
The MICA-NKG2D axis in clear cell renal cell carcinoma bolsters MICA as target in immuno-oncology	27
Immunogenic stress induced by local anesthetics injected into neoplastic lesions	27
Synergistic effect of combining sunitinib with a peptide-based vaccine in cancer treatment after microenvironment remodeling	27
Clostridium butyricum therapy restores the decreased efficacy of immune checkpoint blockade in lung cancer patients receiving proton pump inhibitors	27
Prognostic impact of the bone marrow tumor microenvironment, HLA-I and HLA-Ib expression in MDS and CMML progression to sAML	27
Phenotypic characterization of spatial immune infiltration niches in non-small cell lung cancer	26
Tumor-infiltrating B cells produce tumor-specific antibodies and may contribute to suppressing tumor in head and neck squamous cell carcinoma	26
Overcoming T cell dysfunction in acidic pH to enhance adoptive T cell transfer immunotherapy	26
Trial watch: beta-blockers in cancer therapy	26
Accumulation of tissue-resident natural killer cells, innate lymphoid cells, and CD8 ⁺ T cells towards the center of human lung tumors	26
A newly discovered PD-L1 B-cell epitope peptide vaccine (PDL1-Vaxx) exhibits potent immune responses and effective anti-tumor immunity in multiple syngeneic mice models and (synergizes) in combination	26
Liver metastases of colorectal cancer contain different subsets of tissue-resident memory CD8 T cells correlated with a distinct risk of relapse following surgery	26
Helicobacter pylori serology is associated with worse overall survival in patients with melanoma treated with immune checkpoint inhibitors	25
TNFR2/CCR8 bispecific antibody enhances antitumor activity through depleting Ti-Tregs and boosting effector CD8 ⁺ T cell function	25
A PD-L1/EGFR bispecific antibody combines immune checkpoint blockade and direct anti-cancer action for an enhanced anti-tumor response	24
The LXRβ/NF-κB axis reprograms CAR-T cells to resist exhaustion in the tumor microenvironment	24
Peripheral memory B cell population maintenance and long-term survival after perioperative chemoimmunotherapy in NSCLC (NADIM trial)	24
Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice	22
Surrogate markers of intestinal dysfunction associated with survival in advanced cancers	22
M2 macrophage-derived exosomes suppress tumor intrinsic immunogenicity to confer immunotherapy resistance	21
Immune response to SARS-CoV-2 mRNA vaccination and booster dose in patients with multiple myeloma and monoclonal gammopathies: impact of Omicron variant on the humoral response	21
Differential impact of genetic deletion of TIGIT or PD-1 on melanoma-specific T-lymphocytes	21
Tertiary lymphoid structure-related immune infiltrates in NSCLC tumor lesions correlate with low tumor-reactivity of TIL products	21
Candidate tumor-specific CD8 ⁺ T cell subsets identified in the malignant pleural effusion of advanced lung cancer patients by single-cell analysis	21
Mitochondrial DNA transfer between malignant cells and T lymphocytes shapes the cancer-immunity dialogue	21
Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia	20
Local therapy with combination TLR agonists stimulates systemic anti-tumor immunity and sensitizes tumors to immune checkpoint blockade	20

FDA approves lurbinectedin in combination with atezolizumab for extensive-stage small cell lung cancer	20
Schweinfurthin induces ICD without ER stress and caspase activation	20
CD8 ⁺ T cells in breast cancer tumors and draining lymph nodes: PD-1 levels, effector functions and prognostic relevance	20
Trial Watch: combination of tyrosine kinase inhibitors (TKIs) and immunotherapy	20
Clinical prognosticators and targets in the immune microenvironment of intrahepatic cholangiocarcinoma	20
Preexisting autoantibodies as predictor of immune related adverse events (irAEs) for advanced solid tumors treated with immune checkpoint inhibitors (ICIs)	19
CD20 expression regulates CD37 levels in B-cell lymphoma – implications for immunotherapies	19
Gasdermin E links tumor cell-intrinsic nucleic acid signaling to proinflammatory cell death for successful checkpoint inhibitor cancer immunotherapy	19
MHCII restriction demonstrates B cells have very limited capacity to activate tumour-specific CD4 ⁺ T cells in vivo	19
A novel membrane-bound interleukin-2 promotes NK-92 cell persistence and anti-tumor activity	19
Local delivery of interleukin 7 with an oncolytic adenovirus activates tumor-infiltrating lymphocytes and causes tumor regression	19
IL-21-reprogrammed Vδ1 T cells exert killing against solid tumors which is enhanced by CAR arming for off-the-shelf immunotherapy	19
Benzodiazepines interfere with the efficacy of pembrolizumab-based cancer immunotherapy. Results of a nationwide cohort study including over 50,000 participants with advanced lung cancer	19
Glucose metabolism inhibitor PFK-015 combined with immune checkpoint inhibitor is an effective treatment regimen in cancer	18
Enriched circulating and tumor-resident TGF-β ⁺ regulatory B cells in patients with melanoma promote FOXP3 ⁺ Tregs	18
High-grade serous ovarian cancer development and anti-PD-1 resistance is driven by IRE1α activity in neutrophils	18
Utilization of universal-targeting mSA2 CAR-T cells for the treatment of glioblastoma	18
BCG-activation of leukocytes is sufficient for the generation of donor-independent innate anti-tumor NK and γδ T-cells that can be further expanded in vitro	18
Piezo1 facilitates optimal T cell activation during tumor challenge	18
Monocytes acquire a tumor-associated IL1B program upon encountering patient-derived colon cancer organoids	18
Activation of endogenous glucocorticoids by HSD11B1 inhibits the antitumor immune response in renal cancer	18
Expression of CD39 is associated with T cell exhaustion in ovarian cancer and its blockade reverts T cell dysfunction	18
Cell type-specific induction of ferroptosis to boost antitumor immunity	17
Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo	17
Formyl peptide receptor-1 (FPR1) represses intestinal oncogenesis	17
Regional immune mechanisms enhance efficacy of an autologous cellular cancer vaccine with intraperitoneal administration	17
Metabolic heterogeneity in tumor cells impacts immunology in lung squamous cell carcinoma	17
Multiprong CD38 targeting to enhance anti-PD1 immune checkpoint blockade efficacy	17
The long-lasting expression of recombinant artLCMV following intraperitoneal administration exerts potent antitumor effects on tumor models of peritoneal carcinomatosis	16
Non-pharmaceutical interventions to optimize cancer immunotherapy	16
Cytokine release syndrome after treatment with immune checkpoint inhibitors: an observational cohort study of 2672 patients from Karolinska University Hospital in Sweden	16
Intratumoral regulatory T cells are associated with treatment response to neoadjuvant chemotherapy and prognosis in gastroesophageal adenocarcinoma	16
Arsenic trioxide as an inducer of immunogenic cell death	16
Single-cell RNA-sequencing reveals predictive features of response to pembrolizumab in Sézary syndrome	16
Low triglyceride levels are associated with increased risk of immune-related adverse events in patients receiving immune checkpoint inhibitors	16
Influencing tumor-associated macrophages in malignant melanoma with monoclonal antibodies	16
g-NK cells from umbilical cord blood are phenotypically and functionally different than g-NK cells from peripheral blood	16
Suppression of prostate cancer and amelioration of the immunosuppressive tumor microenvironment through selective immunoproteasome inhibition	16
Systemic administration of a viral nanoparticle neoadjuvant prevents lung metastasis development through emergency myelopoiesis	15
Single-cell analysis of T lymphocytes infiltrating colorectal carcinoma: the dilemma of specificity	15
Extracellular vesicles released by cancer-associated fibroblast-induced myeloid-derived suppressor cells inhibit T-cell function	15
How macrophages use extracellular calreticulin to chase their prey	15
Are tumor-associated carbohydrates the missing link between the gut microbiome and response to immune checkpoint inhibitor treatment in cancer?	15
Cytoplasmic HMGB2 orchestrates CALR translocation in the course of immunogenic cell death	15
CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis	15
CD4 ⁺ tumor-infiltrating lymphocytes secreting T cell-engagers induce regression of autologous patient-derived non-small cell lung cancer xenografts	15
Correction	15
Combination of T cell-redirecting strategies with a bispecific antibody blocking TGF-β and PD-L1 enhances antitumor responses	15
Human allogenic γδ T cells kill patient-derived glioblastoma cells expressing high levels of DNAM-1 ligands	15
Cerebrospinal fluid immunological cytokines predict intracranial tumor response to immunotherapy in non-small cell lung cancer patients with brain metastases	15
Early local immune activation following intra-operative radiotherapy in human breast tissue	14
Immunotherapy approaches for the treatment of diffuse midline gliomas	14
Combined tumor-associated microbiome and immune gene expression profiling predict response to neoadjuvant chemo-radiotherapy in locally advanced rectal cancer	14
An SNP-dependent cancer-testis antigenic epitope serves as a promising immunotherapeutic target for cancer	14
Cross-disease integration of single-cell RNA sequencing data from lung myeloid cells reveals TAM signature in in vitro model	14
CD25 ^bright NK cells display superior function and metabolic activity under regulatory T cell-mediated suppression	14
The landscape of T-cell engagers for the treatment of follicular lymphoma	14
Salmonella immunotherapy engineered with highly efficient tumor antigen coating establishes antigen-specific CD8+ T cell immunity and increases in antitumor efficacy with type I int	14
Characterization of innate lymphoid cell subsets infiltrating melanoma and epithelial ovarian tumors	14
Type I interferon induces cancer stem cells-mediated chemotherapy resistance	14
Metabolic regulation of the mitochondrial immune checkpoint	14