OOIR: Observatory of International Research

Papers

(The H4-Index of Molecular Therapy-Nucleic Acids is 44. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
MicroRNA-466 and microRNA-200 increase endothelial permeability in hyperglycemia by targeting Claudin-5	153
All roads lead to cure: Diversity of oligonucleotides in DM1 therapy	118
Inefficacy of anti-VEGF therapy reflected in VEGF-mediated photoreceptor degeneration	86
Insights into the regulatory role of epigenetics in moyamoya disease: Current advances and future prospectives	77
Endothelial derived, secreted long non-coding RNAs Gadlor1 and Gadlor2 aggravate cardiac remodeling	75
Activating the Cpx response induces tolerance to antisense PNA delivered by an arginine-rich peptide in Escherichia coli	74
Effective intravitreal gene delivery to retinal pigment epithelium with hyaluronic acid nanospheres	74
Gene-repressing epigenetic reader EED unexpectedly enhances cyclinD1 gene activation	71
Cas-CLOVER is a novel high-fidelity nuclease for safe and robust generation of TSCM-enriched allogeneic CAR-T cells	70
AAV-vectored base editor trans-splicing delivers dystrophin repair	69
RETRACTED: H3K27 demethylase KDM6B aggravates ischemic brain injury through demethylation of IRF4 and Notch2-dependent SOX9 activation	69
LinQURE: A novel AAV gene silencing platform that supports multi-transcript targeting for complex disorders	69
Retraction Notice to: Hypoxic tumor-derived exosomal circular RNA SETDB1 promotes invasive growth and EMT via the miR-7/Sp1 axis in lung adenocarcinoma	68
HOXA5-miR-574-5p axis promotes adipogenesis and alleviates insulin resistance	67
Single-swap editing for the correction of common Duchenne muscular dystrophy mutations	65
A bimolecular modification strategy for developing long-lasting bone anabolic aptamer	65
Exosomal miR-590-3p derived from cancer-associated fibroblasts confers radioresistance in colorectal cancer	65
Combining nonsense mutation suppression therapy with nonsense-mediated decay inhibition in neurofibromatosis type 1	65
Implications of miR-148a-3p/p35/PTEN signaling in tau hyperphosphorylation and autoregulatory feedforward of Akt/CREB in Alzheimer’s disease	63
Modulation of miR-29 influences myocardial compliance likely through coordinated regulation of calcium handling and extracellular matrix	63
Antisense oligonucleotide-mediated exon 27 skipping restores dysferlin function in dysferlinopathy patient-derived muscle cells	62
Unlocking RNA mysteries: Predicting subcellular localizations with AI	62
Forced enhancer-promoter rewiring to alter gene expression in animal models	59
Emerging roles of circRNAs in the pathological process of myocardial infarction	59
Mitochondrial double-stranded RNAs as a pivotal mediator in the pathogenesis of Sjӧgren’s syndrome	58

Alleviation of ischemia-reperfusion induced renal injury by chemically modified SOD2 mRNA delivered via lipid nanoparticles	57
Novel insights into the interaction between N6-methyladenosine modification and circular RNA	56
Enhanced molecular dynamic simulation studies unravel long-range effects caused by sequence variations and partner binding in RNA aptamers	56
Highly efficient A-to-G base editing by ABE8.17 in rabbits	55
Single-cell transcriptome profiling implicates the psychological stress-induced disruption of spermatogenesis	54
Efficient transfected liposomes co-loaded with pNrf2 and pirfenidone improves safe delivery for enhanced pulmonary fibrosis reversion	52
Engineering B cells with customized therapeutic responses using a synthetic circuit	51
tRF-1001: A potential therapeutic target for ocular neovascular diseases	51
Right on target: The next class of efficient, safe, and specific RNAi triggers	51
Structural variants and modifications of hammerhead ribozymes targeting influenza A virus conserved structural motifs	49
RNA therapeutics in targeting G protein-coupled receptors: Recent advances and challenges	49
DNA-PKcs inhibition improves sequential gene insertion of the full-length CFTR cDNA in airway stem cells	48
CleanCap M6 inhibits decapping of exogenously delivered IVT mRNA	48
Redefining NSP12 activity in SARS-CoV-2 and its regulation by NSP8 and NSP7	47
Extracellular viral microRNAs as biomarkers of virus infection in human cells	47
Nucleic acid delivery for pathology treatment: RNA tissue delivery	47
miR-6077 promotes cisplatin/pemetrexed resistance in lung adenocarcinoma via CDKN1A/cell cycle arrest and KEAP1/ferroptosis pathways	46
miR-204 suppresses cancer stemness and enhances osimertinib sensitivity in non-small cell lung cancer by targeting CD44	45
Joint masking and self-supervised strategies for inferring small molecule-miRNA associations	44
Double-stranded RNA induction asa potential dynamic biomarkerfor DNA-demethylating agents	44
Precise detection of CRISPR-Cas9 editing in hair cells in the treatment of autosomal dominant hearing loss	44
Inhibition of microRNA-30a alleviates vascular remodeling in pulmonary arterial hypertension	44
HnRNP-L-regulated circCSPP1/miR-520h/EGR1 axis modulates autophagy and promotes progression in prostate cancer	44
Cancer immunomodulation using bispecific aptamers	44