OOIR: Observatory of International Research

Papers

(The H4-Index of Molecular Therapy-Nucleic Acids is 45. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Implications of circular transcripts in DM1 pathomechanism	172
Inefficacy of anti-VEGF therapy reflected in VEGF-mediated photoreceptor degeneration	106
RETRACTED: HOXA5-miR-574-5p axis promotes adipogenesis and alleviates insulin resistance	98
Forced enhancer-promoter rewiring to alter gene expression in animal models	93
Cas-CLOVER is a novel high-fidelity nuclease for safe and robust generation of TSCM-enriched allogeneic CAR-T cells	82
Retraction Notice to: Hypoxic tumor-derived exosomal circular RNA SETDB1 promotes invasive growth and EMT via the miR-7/Sp1 axis in lung adenocarcinoma	80
Effective intravitreal gene delivery to retinal pigment epithelium with hyaluronic acid nanospheres	79
Highly efficient A-to-G base editing by ABE8.17 in rabbits	75
Implications of miR-148a-3p/p35/PTEN signaling in tau hyperphosphorylation and autoregulatory feedforward of Akt/CREB in Alzheimer’s disease	74
Alleviation of ischemia-reperfusion induced renal injury by chemically modified SOD2 mRNA delivered via lipid nanoparticles	73
Gene-repressing epigenetic reader EED unexpectedly enhances cyclinD1 gene activation	72
AAV-vectored base editor trans-splicing delivers dystrophin repair	71
Unlocking RNA mysteries: Predicting subcellular localizations with AI	68
LinQURE: A novel AAV gene silencing platform that supports multi-transcript targeting for complex disorders	68
Ferroptosis as a therapeutic target in glioblastoma: Mechanisms and emerging strategies	65
SPRINGing forward: Advancing RNA editing efficiency and precision with engineered ADAR2	65
An oversized AAV8 vector to deliver CPS1	64
Durable HTT silencing using non-evolved dCas9 epigenome editors in patient-derived cells	64
All roads lead to cure: Diversity of oligonucleotides in DM1 therapy	62
Modulation of miR-29 influences myocardial compliance likely through coordinated regulation of calcium handling and extracellular matrix	61
Mitochondrial double-stranded RNAs as a pivotal mediator in the pathogenesis of Sjӧgren’s syndrome	57
Antisense oligonucleotide-mediated exon 27 skipping restores dysferlin function in dysferlinopathy patient-derived muscle cells	56
Efficient transfected liposomes co-loaded with pNrf2 and pirfenidone improves safe delivery for enhanced pulmonary fibrosis reversion	55
Endothelial derived, secreted long non-coding RNAs Gadlor1 and Gadlor2 aggravate cardiac remodeling	54
cncFinder: a graph attention network-based interpretable learning model to identify bifunctional long non-coding RNAs	54

A bimolecular modification strategy for developing long-lasting bone anabolic aptamer	52
Insights into the regulatory role of epigenetics in moyamoya disease: Current advances and future prospectives	51
Progress and prospect of minicircle as a minimized non-viral DNA vector in gene therapy and regenerative medicine	51
Combining nonsense mutation suppression therapy with nonsense-mediated decay inhibition in neurofibromatosis type 1	51
Base editing strategies for in vivo correction of two highly recurrent phenylketonuria variants	50
Comparison of MALAT1 antisense oligonucleotide distribution following intracerebroventricular and lumbar intrathecal routes of administration	50
Novel eRF3a degrader enhances gentamicin-induced premature termination codon readthrough in epidermolysis bullosa	49
A novel gene therapy platform for the treatment of type 2 diabetes and obesity	49
A potent GalNAc-siRNA drug, RBD1016, leads to sustained HBsAg reduction and seroconversion in mouse models of HBV infection	48
Novel insights into the interaction between N6-methyladenosine modification and circular RNA	48
MicroRNA-466 and microRNA-200 increase endothelial permeability in hyperglycemia by targeting Claudin-5	48
Single-swap editing for the correction of common Duchenne muscular dystrophy mutations	48
Single-cell transcriptome profiling implicates the psychological stress-induced disruption of spermatogenesis	48
Enhanced molecular dynamic simulation studies unravel long-range effects caused by sequence variations and partner binding in RNA aptamers	47
Deficiency of miR-409-3p improves myocardial neovascularization and function through modulation of DNAJB9/p38 MAPK signaling	46
Change of intracellular calcium level causes acute neurotoxicity by antisense oligonucleotides via CSF route	46
Double-stranded RNA induction asa potential dynamic biomarkerfor DNA-demethylating agents	45
Cancer immunomodulation using bispecific aptamers	45
Intermittent lipid nanoparticle mRNA administration prevents cortical dysmyelination associated with arginase deficiency	45
Topical application of a CCL22-binding aptamer suppresses contact allergy	45
Precise detection of CRISPR-Cas9 editing in hair cells in the treatment of autosomal dominant hearing loss	45