OOIR: Observatory of International Research

Papers

(The H4-Index of Molecular Therapy-Nucleic Acids is 44. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
FTO deficiency facilitates epithelia dysfunction in oral lichen planus	148
DdCBE mediates efficient and inheritable modifications in mouse mitochondrial genome	114
Long noncoding RNA LUCAT1 enhances the survival and therapeutic effects of mesenchymal stromal cells post-myocardial infarction	99
HOXA5-miR-574-5p axis promotes adipogenesis and alleviates insulin resistance	94
rAAV-delivered PTEN therapeutics for prostate cancer	92
Neutrophil-like cell membrane-coated siRNA of lncRNA AABR07017145.1 therapy for cardiac hypertrophy via inhibiting ferroptosis of CMECs	91
Mechanism of action of hepatitis B virus S antigen transport-inhibiting oligonucleotide polymer, STOPS, molecules	75
miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review	72
Dysregulation of the miRNome unveils a crosstalk between obesity and prostate cancer: miR-107 asa personalized diagnostic and therapeutic tool	71
Proof of concept of peptide-linked blockmiR-induced MBNL functional rescue in myotonic dystrophy type 1 mouse model	67
hsa_circ_0005358 suppresses cervical cancer metastasis by interacting with PTBP1 protein to destabilize CDCP1 mRNA	66
Engineering miRNA features into siRNAs: Guide-strand bulges are compatible with gene repression	66
Anti-EFG1 2′-OMethylRNA oligomer inhibits Candida albicans filamentation and attenuates the candidiasis in Galleria mellonella	64
Novel insights into the interaction between N6-methyladenosine modification and circular RNA	62
Loss of full-length pumilio 1 abrogates miRNA-221-induced gene p27 silencing-mediated cell proliferation in the heart	60
Analysis and identification of m6A RNA methylation regulators in metastatic osteosarcoma	59
TMEM97 governs partial epithelial-mesenchymal transition of retinal pigment epithelial cells via the CTNND2-ADAM10 axis	57
Lowering an ER stress-regulated long noncoding RNA protects mice from diabetes and isolated pancreatic islets from cell death	57
Highly efficient A-to-G base editing by ABE8.17 in rabbits	57
Changes in ratio of microRNA-29 to microRNA-199 expression Coordinate Mesenchymal Stem Cell Induced Repair of Bleomycin-induced Pulmonary Injury in Aged Mice	57
NGS-based accurate and efficient detection of circulating cell-free mitochondrial DNA in cancer patients	56
Exosomal miR-590-3p derived from cancer-associated fibroblasts confers radioresistance in colorectal cancer	56
Splice-switching antisense oligonucleotide controlling tumor suppressor REST is a novel therapeutic medicine for neuroendocrine cancer	56
The gene silencing of IRF5 and BLYSS effectively modulates the outcome of experimental lupus nephritis	55
mRNA-based therapy in a rabbit model of variegate porphyria offers new insights into the pathogenesis of acute attacks	55

A pan-tumor-siRNA aptamer chimera to block nonsense-mediated mRNA decay inflames and suppresses tumor progression	55
Advancing peptide siRNA-carrier designs through L/D-amino acid stereochemical modifications to enhance gene silencing	53
Phosphatidylcholine head group chemistry alters the extrahepatic accumulation of lipid-conjugated siRNA	52
Anti-miR-141-3p maintains homeostasis between autophagy and apoptosis by targeting Yy1 in the fetal lumbosacral defecation center of rats	52
Inefficacy of anti-VEGF therapy reflected in VEGF-mediated photoreceptor degeneration	52
A cystic fibrosis gene editing approach that is on target	50
AntimiR targeting of microRNA-134 reduces seizures in a mouse model of Angelman syndrome	49
ICLRBBN: a tool for accurate prediction of potential lncRNA disease associations	49
The Aptamer Ob2, a novel AChE inhibitor, restores cognitive deficits and alleviates amyloidogenesis in 5×FAD transgenic mice	49
Chemically modified MIR143-3p exhibited anti-cancer effects by impairing the KRAS network in colorectal cancer cells	49
Engineered deaminases as a key component of DNA and RNA editing tools	49
Endoplasmic reticulum stress promotes sorafenib resistance via miR-188-5p/hnRNPA2B1-mediated upregulation of PKM2 in hepatocellular carcinoma	48
Plasmid encoding microRNA-200c ameliorates periodontitis and systemic inflammation in obese mice	47
Evaluation of the effect of RNA secondary structure on Cas13d-mediated target RNA cleavage	46
miR-351-5p/Miro2 axis contributes to hippocampal neural progenitor cell death via unbalanced mitochondrial fission	46
miR-379 mediates insulin resistance and obesity through impaired angiogenesis and adipogenesis regulated by ER stress	45
Exploring pulmoprotection in COVID-19: Moving toward microRNA-based theranostics	44
mitoTALEN reduces the mutant mtDNA load in neurons	44
Global characterization of RNA editing in genetic regulation of multiple ovarian cancer subtypes	44