OOIR: Observatory of International Research

Papers

(The H4-Index of ACS Synthetic Biology is 40. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Synthetic Biology 2.0: The Dawn of a New Era	96
Directed Evolution of a SelB Variant that Does Not Require a Selenocysteine Insertion Sequence Element for Function	96
Desiccated Cyanobacteria Serve As Efficient Plasmid DNA Carriers in Space Flight	88
Discovering Content through Text Mining for a Synthetic Biology Knowledge System	82
Mobile Translation Systems Generate Genomically Engineered Escherichia coli Cells with Improved Growth Phenotypes	81
Preventing Production Escape Using an Engineered Glucose-Inducible Genetic Circuit	81
The Japan-UK Synthetic Biology Conference, Spring 2025: Strengthening Global Links to Engineer Biology	71
Simplified Construction of Engineered Bacillus subtilis Host for Improved Expression of Proteins Harboring Noncanonical Amino Acids	71
Nano-Regulation of Gene Expression in Chlamydomonas reinhardtii: Harnessing AuNPs for Remotely Switchable Lipid Biosynthesis via Antisense Oligonucleotides	70
Cell-Free Expression of Soluble Leafhopper Proteins from Brochosomes	66
LOICA: Integrating Models with Data for Genetic Network Design Automation	64
Engineered Mutants of a Marine Photosynthetic Purple Nonsulfur Bacterium with Increased Volumetric Productivity of Polyhydroxyalkanoate Bioplastics	63
Protease-Responsive Toolkit for Conditional Targeted Protein Degradation	62
Metabolic Engineering of Clostridium tyrobutyricum for High-Yield n-Butanol Production by Increasing Intracellular Reducing Equivalent with NADPH-Dependent 3-Hydroxybutyryl-CoA Dehydroge	61
In VivoSampling of Intracellular Heterogeneity ofPseudomonas putidaEnables Multiobjective Optimization of Genetic Devices	59
Cell-Free Transcription and Translation Tether Expressed Peptides to Their Encoding Circular DNA	58
Engineered l-Lactate Responding Promoter System Operating in Glucose-Rich and Anoxic Environments	56
Metabolic Engineering of Microbial Chassis Cells for d-Pantothenate Production: A Review	55
Strategies for Improved Docosahexaenoic Acid Synthesis in Microalgae	54
Efficient Genome Editing in Most Staphylococcus aureus by Using the Restriction-Modification System Silent CRISPR-Cas9 Toolkit	53
Improved Cell-Free Transcription–Translation Reactions in Microfluidic Chemostats Augmented with Hydrogel Membranes for Continuous Small Molecule Dialysis	52
Maximizing Heterologous Expression of Engineered Type I Polyketide Synthases: Investigating Codon Optimization Strategies	51
Recent Advances in the Biological Synthesis of l-Tyrosine Derivatives by Genetically Engineered Microbes	50
Development of a Recombineering System for the Acetogen Eubacterium limosum with Cas9 Counterselection for Markerless Genome Engineering	49
Issue Publication Information	48

Highly Accurate Sequence- and Position-Independent Error Profiling of DNA Synthesis and Sequencing	48
Control of λ Lysogenic Escherichia coli Cells by Synthetic λ Phage Carrying cI^antisense	48
Engineering a Novel Acetyl-CoA Pathway for Efficient Biosynthesis of Acetyl-CoA-Derived Compounds	47
Optimal LentiCRISPR-Based System for Sequential CRISPR/Cas9 Screens	47
Lipid Modification and Membrane Localization of Proteins in Cell-Free System	47
Cell-Free Protein Synthesis as a Method to Rapidly Screen Machine Learning-Generated Protease Variants	46
Plasmid Copy Number Engineering Accelerates Fungal Polyketide Discovery upon Unnatural Polyketide Biosynthesis	44
Targeting Transcriptional and Translational Hindrances in a Modular T7RNAP Expression System in Engineered Pseudomonas putida	44
Combining Chemical Catalysis with Enzymatic Steps for the Synthesis of the Artemisinin Precursor Dihydroartemisinic Acid	43
IWBDA 2022: Toward a Modular Future of Synthetic Biology Driven by Bio-Design Automation	43
Energy Aware Technology Mapping of Genetic Logic Circuits	43
DisGUVery: A Versatile Open-Source Software for High-Throughput Image Analysis of Giant Unilamellar Vesicles	43
An Autocatalytic Peptide Cyclase Improves Fidelity and Yield of Circular Peptides In Vivo and In Vitro	42
A Logically Reversible Double Feynman Gate with Molecular Engineered Bacteria Arranged in an Artificial Neural Network-Type Architecture	41
A Photoresponsive Homing Endonuclease for Programmed DNA Cleavage	40
Predicting and Interpreting Protein Developability Via Transfer of Convolutional Sequence Representation	40
Synthetic Biology Design as a Paradigm Shift toward Manufacturing Affordable Adeno-Associated Virus Gene Therapies	40