Cancer Discovery

Article	Citations
Drafting a Blueprint for European Cancer Research	345
Highlighted research articles	329
Q&A: Philip Greenberg on T Cells, IO's Future	294
Mutation-Driven Alveolar Cell Reprogramming Dictates Lung Cancer Progression	281
AI-Supported Mammography “Safe,” Cuts Workload	281
Succinyl-CoA and Cobalamin Are Biomarkers That Improve Anal Cancer Screening	271
Human Tumor Cells Display an Oncogene-like Addiction to Aneuploidy	235
Probing Clonal Hematopoiesis in Liquid Biopsy	231
Shattered Chromosomes Undergo Mitotic Tethering during Chromothripsis	200
PARADIGM Identifies Associations between Drugs, the Microbiome, and Mortality	191
Highlighted research articles	188
Proteostasis Network Modulation Promotes Resistance to KRAS Inhibitors	188
Trispecifics Improve Immune-Cell Engagement	184
An NK-cell Therapy for CD30+ Lymphomas	177
Lymph Node Metastasis Induces Immune Tolerance and Distant Metastasis	174
RAS Drives Malignancy through Altered Stem Cell/Microenvironment Cross-talk	170
IL7 Genetic Variation Predicts Immune-Related Adverse Events	167
Convergence of Targeted and Immune Therapies for the Treatment of Oncogene-Driven Cancers	161
REFLECTions on Combination Therapies Empowered by Data Sharing	154
Reversing Immune Aging to Improve Immunotherapy Outcomes	151
Disrupting MYC RNA Interactions Promotes Tumor Regression	150
GIST: Molecular Profiling Suggests 2nd Therapy	147
Transposable Element Signatures Define Stages of T-cell Exhaustion	146
Correction: Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer	145
The Dark Side of NK Cells in Cancer Immunotherapy	144

Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma	141
Therapy-related mutational signatures in subsequent neoplasms among survivors of childhood cancer	139
Air Pollution Promotes Oncogenic Expansion of Mutant Lung Progenitor Cells	136
Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta	136
Selpercatinib Shifts Treatment Paradigm for MTC and NSCLC	134
PIN1 Prolyl Isomerase Promotes Initiation and Progression of Bladder Cancer through the SREBP2-Mediated Cholesterol Biosynthesis Pathway	133
Combination Diagnostics: Adding Blood-Based ctDNA Screening to Low-Dose CT Imaging for Early Detection of Lung Cancer	129
Liver Response to Metabolic Stress Drives Cancer-associated Programs	127
Dendritic Cell Circadian Rhythm Governs the Antitumor Immune Response	127
HLA-E:CD94–NKG2A Mediates Circulating Tumor Cell Immune Evasion	126
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission	125
Longitudinal Plasma Metabolomics Guides Dynamic Risk Assessment and Dietary Modulation for Esophageal Squamous Cell Cancer Chemoimmunotherapy	124
The 3D Revolution in Cancer Discovery	119
Intrinsic Properties of the Lymph Node Render It Immunologically Susceptible to Metastasis	118
A Guide to Extrachromosomal DNA: Cancer’s Dynamic Circular Genome	116
p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression	114
Rational Protein Engineering to Enhance MHC-Independent T-cell Receptors	114
Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma	113
Cytosolic Phospholipase A2 Determines Intercellular Heterogeneity of Stress Granules and Chemotherapy Response	113
Circulating Tumor Cells Predict Response to the DLL3-Targeting Bispecific Antibody Tarlatamab	112
Gut Microbiota Modulation through Akkermansia spp . Supplementation Increases CAR T-cell Potency	112
A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy	111
CHD2 Regulates Neuron–Glioma Interactions in Pediatric Glioma	109
Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression	109
New Strategy May Thwart Glioblastoma Resistance	106
Presurgery Plus Postsurgery Immunotherapy Ups Survival in NSCLC	106
FMRP Depletion Reprograms an Immunosuppressive Microenvironment	105
The Proteasome Regulator PSME4 Modulates Antitumor Immunity	104
Tumor-Derived Extracellular Vesicles and Particles Inhibit Liver Function	102
Chronic Inflammation Drives TP53-Mutant Leukemic Evolution	100
Multicellular Spatial Organization Determines Immunotherapy Response	100
Revumenib Is Safe and Efficacious, but MEN1 Mutations Mediate Resistance	99
What's Next for Sotorasib in NSCLC?	98
Aged Lungs Enable Metastatic Outgrowth of Dormant Melanoma Cells	97
Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Protumorigenic T-cell Polarization	95
In This Issue	95
Moving Spatially Resolved Multiplexed Protein Profiling toward Clinical Oncology	95
TILs Outperform Ipilimumab in Melanoma	94
Hyperactivation of Oncogenic Pathways Hinders Cancer Cell Survival	94
Lymph Node–Specific IFNγ Levels Affect CD8+ T-cell Priming against Tumors	93
Noninvasive and Multicancer Biomarkers: The Promise of LINE-1 Retrotransposons	92
The Moving Target: Cis -Mutation–Driven Resistance to p53-Y220C Reactivator	91
Bridging the Gap between Diseases of the Stomach and Lower Esophagus	91
Myofibroblasts Induce Neuroplasticity to Promote Pancreatic Inflammation and Cancer Progression	90
Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer	90
Landmark Pediatric Cancer Legislation Aims to Incentivize Research	90
Multimodal AI Model Predicts Breast Cancer Recurrence	89
Beneath the Surface: Neoantigens beyond Chromosomal DNA Mutations	89
Cancer in the Prime of Life: Etiologic Insights and Supportive Oncologic Interventions for the Rising Burden of Young Adult Cancer	89
Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity	89

A Molecular Voyage: Multiomics Insights into Circulating Tumor Cells	86
Atypical Small Cell Lung Cancer: A New Malignancy Characterized by Chromothripsis, Carcinoid Tumors, and Wild-type RB1 and TP53	86
Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy	85
Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth	84
AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer	84
The Kinase Module of the Mediator Complex Inhibits CAR T-cell Function	81
MCED Testing Enters New Diagnostic Realms	81
Study Sniffs Out New Glioma Mechanism	80
Chromatin Remodeling Factors Drive Epigenetic Changes Crucial for T-cell Exhaustion	79
A Spatiotemporal Positive Feedback Loop Exists Between TAMs and CD8+ T Cells	78
Distinct Clonal Patterns Exist between Benign and Malignant Tissue	77
Heritable Defects in Mitotic and Telomere Function Confer Sarcoma Risk	76
ABBV-383 Demonstrates Tolerability and Efficacy in Relapsed/Refractory MM	76
Lasker Honors Discovery of Cell Adhesion Molecules	76
Q&A: Robert Vonderheide on Immunotherapy Advances	75
High-Purity CTC RNA Sequencing Identifies Prostate Cancer Lineage Phenotypes Prognostic for Clinical Outcomes	74
Cancer Neuroscience of Brain Tumors: From Multicellular Networks to Neuroscience-Instructed Cancer Therapies	73
STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts	73
D3S-001, a KRAS G12C Inhibitor with Rapid Target Engagement Kinetics, Overcomes Nucleotide Cycling, and Demonstrates Robust Preclinical and Clinical Activities	73
Air Pollution–Lung Cancer Link Identified	72
Highlighted Research Articles	71
Cancer Cells Adapt to SWI/SNF Inhibition through Compensatory EP400 Function	71
A Transitional Cell Population Is Enriched in Aggressive Human Medulloblastoma	71
MDM2-PROTAC versus MDM2 Inhibitors: Beyond p53 Reactivation	70
Single-Cell Sequencing Reveals Trajectory of Tumor-Infiltrating Lymphocyte States in Pancreatic Cancer	70
IL6 Blockade Reduces Immunotherapy-Induced Immune-Related Adverse Events	70
MEDI5752 Suppresses Two Immune Checkpoints	69
Sex Hormone Signaling Suppresses Ferroptosis via Phospholipid Remodeling	69
Prenatal Chemotherapy and Its Impact on the Genome of Fetal Hematopoiesis	69
The Hallmarks of Predictive Oncology	68
Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibit	68
Integrative Analysis of a Large Real-World Cohort of Small Cell Lung Cancer Identifies Distinct Genetic Subtypes and Insights into Histologic Transformation	68
CD19/CD20 Bispecific Chimeric Antigen Receptor (CAR) in Naive/Memory T Cells for the Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma	67
Acquired Cross-Resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC Paralogs	66
Oncogenic and Tumor-Suppressive Events Act on a Progenitor State to Promote or Prevent Malignancy	66
Phosphocreatine Promotes Epigenetic Reprogramming to Facilitate Glioblastoma Growth Through Stabilizing BRD2	66
CD8-Targeted IL2 Unleashes Tumor-Specific Immunity in Human Cancer Tissue by Reviving the Dysfunctional T-cell Pool	66
Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia	65
Human Colon Cancer–Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice	65
Advancing Global Health Equity in Oncology Clinical Trial Access	64
A Plastic EMP1+ to LGR5+ Cell State Conversion as a Bypass to KRASG12D Pharmacologic Inhibition in Metastatic Colorectal Cancer	63
Epigenetic Regulation of Chromosomal Instability by EZH2 Methyltransferase	62
MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP -Deleted Cancer	61
Glioma Infiltration and Progression Are Driven by Remote Neuronal Activation	61
Court Rulings Complicate Decisions for Pregnant Patients	60
Carcinogenic Human Metabolites Are Revealed Using “Metabokiller”	59
IL4 Signaling in the Bone Marrow Promotes Protumorigenic Myelopoiesis	59
Distinct Treatment-Related Immunologic Biomarkers Are Identified in PDAC	58
Antitrust Order Aimed at Equalizing MCED Field	58
Glucose Metabolism in TAMs Promotes Metastasis and Drug Resistance	57
Heterologous Cancer Vaccines plus Checkpoint Inhibitors Show Therapeutic Benefit	57
The Evolutionary History of Breast Cancer and Related Clones Is Revealed	57
The APOE–TREM2 Axis Mediates Senescent Neutrophils in Prostate Cancer	57
Highlighted Research Articles	56
Epitope Editing Prevents Off-Tumor Toxicity of CAR T-cell Therapy in AML	55
Methylation Is Best for cfDNA Multicancer Early Detection Tests	54
HeLa Cases Prompt More Thinking on Ethics	54
Clonal Hematopoiesis Enhances Immunotherapy Response in Solid Tumors	53
Tumor-infiltrating Bacteria Induce Quiescence and Therapy Resistance	53
Intra- Versus Extracellular Bacteria Dictate Tumor Immunity and Metastatic Recurrence	53
Arachidonic Acid Metabolism in PMN-MDSCs Suppresses Antitumor Capacity of T cells in KRAS-Mutant Cholangiocarcinoma	52
Tracing Founder Mutations in Circulating and Tissue-Resident Follicular Lymphoma Precursors	52
Gene-Specific Machine Learning Models to Classify Driver Mutations in Clonal Hematopoiesis	51
The Bitter Aftertaste of Artificial Sweeteners in Cancer Immunotherapy	51
Spatial Mapping of the Precancer-to-Cancer Transition in Breast and Prostate	51
Peto’s Paradox Is Dead. Long Live Peto’s Paradox	51
A Deep Learning Model for Cancer Type Prediction Sets a New Standard	51
Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection—Letter	51
Bone-Induced HER2 Promotes Secondary Metastasis in HR+/HER2− Breast Cancer	50
The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade	50
Stromal KITL/SCF Maintains Pancreas Tissue Homeostasis and Restrains Tumor Progression	50
Illuminating a Dark Kinase in the Mesenchymal Cancer Cell State	50
Which Small Molecule? Selecting Chemical Probes for Use in Cancer Research and Target Validation	49
SUV39H1 Ablation Enhances Long-term CAR T Function in Solid Tumors	49
Winning Cancer Grand Challenges Teams Announced	49
Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas	49
The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer	49
CD137 (4-1BB)-Based Cancer Immunotherapy on Its 25th Anniversary	48
When Cancer Cells Become the Enablers of an Antitumor Immune Response	47
Catalytic Inhibition of KAT6/KAT7 Enhances the Efficacy and Overcomes Primary and Acquired Resistance to Menin Inhibitors in MLL Leukemia	47

Combining TIGIT Blockade with MDSC Inhibition Hinders Breast Cancer Bone Metastasis by Activating Antitumor Immunity	47
If You Build It, Patients with Rare Cancers Will Come: A Successful Clinical Trial in Relapsed and Refractory JMML	47
Niche Labeling Reveals Pro-Metastatic Immune-Cancer Cell Interactions	47
Quantifying the Expanding Landscape of Clinical Actionability for Patients with Cancer	45
A High-Fiber, Plant-Based Diet in Myeloma Precursor Disorders: Results from the NUTRIVENTION Clinical Trial and Preclinical Vk*MYC Model	45
Spatially Defined Cellular Niches Forged by Tumor-Intrinsic MHCII Redefine Immune Competence in Ovarian Cancer	44
White House Proposes Cuts to NIH Funding for FY27	44
Cancer-Associated Fibroblasts Serve as Decoys to Suppress NK Cell Anticancer Cytotoxicity in Breast Cancer	43
ImmunoGen Takeover Caps Year of Record ADC Investments	43
Homing In on RNA Fusions in Breast Cancer	43
Tumor Microenvironment Immune Changes Support Anti-CD19 CAR T-cell Efficacy	43
Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence	43
Structure of SHOC2–PP1C–RAS Reveals a Mechanism of RAF Activation	43
Molecular Profiles Distinguish Brain Metastases of Diverse Neural Impact	43
HER2 Expression Impacts Trastuzumab Deruxtecan Efficacy in Breast Cancer	43
A Whole Cancer Cell–Based Vaccine Boosts Cell Killing and Antitumor Immunity	43
Specific Anatomic Transcriptomes Drive Oncogenesis in Melanoma	43
Kidney Cancer Researcher Tapped as NCI Director	43
Lymphocyte Interaction Networks Drive Lung Cancer Immunosurveillance	42
An Atlas of Tumor Metabolism Uncovers Gene–Metabolite Interactions	42
Acknowledgment to Reviewers	42
Culture Media Tweak Makes Heartier CARs	42
Clonal GCB Cells Support Angioimmunoblastic T-cell Lymphoma Tumorigenesis	41
Radical Collaboration: Reimagining Cancer Team Science	41
Highlighted Research Articles	41
So Grateful for My X: Sex Chromosomes Drive Differences in Glioblastoma Immunity	40
IFNα Potentiates Immune-Checkpoint Blockade by Rewiring Metabolic Cross-talk	40
Condensate-Promoting ENL Mutation Drives Tumorigenesis In Vivo Through Dynamic Regulation of Histone Modifications and Gene Expression	39
Loss of p53 Induces Tolerance to Viral Mimicry as a Mechanism of Immune Evasion in Early Tumorigenesis	39
DNAJB1-PRKACA Fusion Drives Fibrolamellar Liver Cancer through Impaired SIK Signaling and CRTC2/p300-Mediated Transcriptional Reprogramming	39
Insights and Opportunity Costs in Applying Spatial Biology to Study the Tumor Microenvironment	38
Toward AI-Powered Cancer Etiology Research	38
Biomolecular Condensation: A New Phase in Cancer Research	38
Targeting Acute Myeloid Leukemia Stem Cells through Perturbation of Mitochondrial Calcium	38
TNF Receptors Choose HSC Fate in Supporting Dnmt3a -Mutant Clonal Hematopoiesis	37
Artificial Intelligence and Machine Learning Technologies in Cancer Care: Addressing Disparities, Bias, and Data Diversity	37
Spectrum of Response to Platinum and PARP Inhibitors in Germline BRCA –Associated Pancreatic Cancer in the Clinical and Preclinical Setting	37
Pushing the Boundaries of Liquid Biopsies for Early Precision Intervention	37
Single-Cell Spatial Atlas of High-Grade Serous Ovarian Cancer Uncovers MHC Class II as a Key Predictor of Spatial Tumor Ecosystems and Clinical Outcomes	37
Senescent Cancer Cells Are Vulnerable to Extrinsic Apoptosis Pathway Activation	36
Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma	36
High-Endothelial Venules Promote Permissive T-cell Niches after Immunotherapy	36
MHC-I Cross-Dressing Supports Antitumor CD8+ T-cell Priming	36
BTK Inhibitor Options Expand for CLL/SLL	36
Single-Cell Tumor–Normal Analysis Proposes Combinatorial CAR Strategies	36
Driver Events of Gastric Cancer Differ According to Subtype and Ancestry	35
Nociceptor Neurons Affect Immunosurveillance and Tumor Growth	35
In This Issue	35
Altered tRNA Isoacceptor Abundance Regulates Breast Cancer Metastasis	35
Disruption of KAT8–IRF1 Condensate Formation Reduces PD-L1 Expression	35
Gut Microbiota Regulate PD-L2 Expression and Immunotherapy Response	34
Intrinsically Disordered Regions Control cBAF Condensation and Interactions	34
PHGDH Inhibition Overcomes Glioblastoma Resistance to T-cell Therapy	34
Primary, Metastatic Tumors Vary Genomically by Cancer Type	34
Artificial Intelligence Identifies Novel Disease Pathways	34
Correction: Animal Alternatives OK'd by New Law	33
Dangerous Liaisons between Tet2 Mutation, Inflammatory Monocytes, and Leukemogenesis	33
Correction: Creating MHC-Restricted Neoantigens with Covalent Inhibitors That Can Be Targeted by Immune Therapy	33
HPV42, a “Low-Risk” Type, and Digital Papillary Adenocarcinoma	33
Correction: Highlights of FDA Oncology Approvals in 2023: Bispecific T-cell Engagers, Pediatric Indications, and Inclusive Drug Development	32
Germline–Somatic Liaison Dictates Cancer Subtypes via de novo Steroid Biosynthesis	32
Personalized mRNA Vaccine Spurs Lasting Immunity in TNBC	31
Y Chromosome Loss Drives Bladder Cancer Aggressiveness and Immune Evasion	31
Tackling Cancer through Global Team Science	30
Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer	30
Immunogenicity and Efficacy of Personalized Adjuvant mRNA Cancer Vaccines	30
Glucocorticoid Receptor Antagonist Approved for Ovarian Cancer	29
GLP-1 RAs May Prevent Metastatic Progression	29
Micronuclei and Cancer	29
LINE-1 Locus Transcription Nucleates Oncogenic Chromatin Architecture	29
The SCRUM-MONSTAR Cancer-Omics Ecosystem: Striving for a Quantum Leap in Precision Medicine	29
Targeting Exposed Phosphatidylserine Boosts Antigen-Specific T-Cell Response	29
A New Class of Molecular Glues: Double Allostery Restores KEAP1 Control of NRF2	29
Cell States in Cancer: Drivers, Passengers, and Trailers	29
Cancer Throughlines: 40 Years After Chernobyl Disaster, Research on Cancer Impact Carries On	28
Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants	28
Noninvasive Detection of Neuroendocrine Prostate Cancer through Targeted Cell-free DNA Methylation	28
A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas	28
The Origin of Highly Elevated Cell-Free DNA in Healthy Individuals and Patients with Pancreatic, Colorectal, Lung, or Ovarian Cancer	28
Mitochondrial Glutathione Import Enables Breast Cancer Metastasis via Integrated Stress Response Signaling	28
Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection	28
Senescence Defines a Distinct Subset of Myofibroblasts That Orchestrates Immunosuppression in Pancreatic Cancer	27
Receptor-interacting Protein Kinase 2 Is an Immunotherapy Target in Pancreatic Cancer	27
Sensitizing Lung Cancer to Immunotherapy with a RAS(ON) Inhibitor Doublet	27
GPRC5D CAR T Cells Are Active in BCMA CAR T–Refractory Multiple Myeloma	26
Noted	26
Noted	26
Leading Oral SERD Shows Prolonged Activity	26
A Trifunctional Natural Killer Cell Engager Can Target CD123+ Leukemia	26
Intratumoral Niches Control CD8+ T-cell Differentiation following ICB	26
FOXA2 Promotes Prostate Cancer Lineage Plasticity through KIT	26
Cold Exposure Suppresses Tumor Growth through BAT Activation	25
Clinically Actionable Alterations Are Associated with African Ancestry	25
Early Clones Expand in Richter Transformation of Chronic Lymphocytic Leukemia	25
A Pan-KRAS Inhibitor Impedes Common KRAS Oncoproteins and Tumor Growth	25