Cancer Discovery

Article	Citations
AI-Supported Mammography “Safe,” Cuts Workload	5688
HLA-E:CD94–NKG2A Mediates Circulating Tumor Cell Immune Evasion	578
Mutation-Driven Alveolar Cell Reprogramming Dictates Lung Cancer Progression	360
Succinyl-CoA and Cobalamin Are Biomarkers That Improve Anal Cancer Screening	307
Human Tumor Cells Display an Oncogene-like Addiction to Aneuploidy	257
Q&A: Philip Greenberg on T Cells, IO's Future	226
Structure of the Tumor Stroma Predicts Invasive Breast Cancer Relapse	214
Shattered Chromosomes Undergo Mitotic Tethering during Chromothripsis	196
PARADIGM Identifies Associations between Drugs, the Microbiome, and Mortality	195
Air Pollution Promotes Oncogenic Expansion of Mutant Lung Progenitor Cells	188
Transposable Element Signatures Define Stages of T-cell Exhaustion	188
Probing Clonal Hematopoiesis in Liquid Biopsy	186
Collagen Receptor Implicated in Immune Exclusion	180
Low-Glycemic Diets Restrict Tumor Growth through Altered Lipid Metabolism	179
Exome Sequencing IDs Hidden Disease Variants	173
IL7 Genetic Variation Predicts Immune-Related Adverse Events	170
Drafting a Blueprint for European Cancer Research	166
RAS Drives Malignancy through Altered Stem Cell/Microenvironment Cross-talk	164
Dendritic Cell Circadian Rhythm Governs the Antitumor Immune Response	153
COVID-19 Reshapes Cancer Clinical Research	149
Myeloid Cells Counter Immune Suppression	148
Colorectal Cancer Screening to Start at 45	148
Blood Cancers Diminish Response to COVID-19 Vaccine	145
Durable Responses with Vemurafenib plus Rituximab in Hairy-Cell Leukemia	143
Mouse Models Provide Insight into Factors Affecting BiTE Efficacy	137

Cytosolic Phospholipase A2 determines Intercellular Heterogeneity of Stress Granules and Chemotherapy Response	137
Highlighted research articles	134
Proteostasis Network Modulation Promotes Resistance to KRAS Inhibitors	130
Adjuvant PD-1 Blockade in Resected Melanoma: Is Preventing Recurrence Enough?	126
REFLECTions on Combination Therapies Empowered by Data Sharing	126
Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma	124
Highlighted research articles	123
Combination Diagnostics: Adding Blood-Based ctDNA Screening to Low-Dose CT Imaging for Early Detection of Lung Cancer	123
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission	122
Convergence of Targeted and Immune Therapies for the Treatment of Oncogene-Driven Cancers	120
Infigratinib Approved for Cholangiocarcinoma	119
Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta	119
PIN1 Prolyl Isomerase Promotes Initiation and Progression of Bladder Cancer through the SREBP2-Mediated Cholesterol Biosynthesis Pathway	117
Correction: Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer	117
Selpercatinib Shifts Treatment Paradigm for MTC and NSCLC	117
An NK-cell Therapy for CD30+ Lymphomas	116
CHD2 Regulates Neuron–Glioma Interactions in Pediatric Glioma	115
Lymph Node Metastasis Induces Immune Tolerance and Distant Metastasis	115
Intrinsic properties of the lymph node render it immunologically susceptible to metastasis	115
A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy	113
p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression	111
Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression	111
A Guide to Extrachromosomal DNA: Cancer’s Dynamic Circular Genome	109
Rational Protein Engineering to Enhance MHC-Independent T-cell Receptors	109
Trispecifics Improve Immune-Cell Engagement	109
The 3D Revolution in Cancer Discovery	108
GIST: Molecular Profiling Suggests 2nd Therapy	108
INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors	108
Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma	102
Multicellular Spatial Organization Determines Immunotherapy Response	100
Chronic Inflammation Drives TP53-Mutant Leukemic Evolution	100
Presurgery Plus Postsurgery Immunotherapy Ups Survival in NSCLC	100
In This Issue	100
Response to Low Antigen Density Is Improved by HLA-Independent T-cell Receptors	98
Amgen Deal Nets Potential Cancer Therapies	97
Intestinal Microbiome Inhibits CD8+ T Cells via the Calcineurin–NFAT Axis	96
Tumor-Derived Extracellular Vesicles and Particles Inhibit Liver Function	96
The Proteasome Regulator PSME4 Modulates Antitumor Immunity	96
FMRP Depletion Reprograms an Immunosuppressive Microenvironment	95
New Strategy May Thwart Glioblastoma Resistance	92
TILs Outperform Ipilimumab in Melanoma	91
Hyperactivation of Oncogenic Pathways Hinders Cancer Cell Survival	91
Lymph Node–Specific IFNγ Levels Affect CD8+ T-cell Priming against Tumors	90
Akk Abundance Alters Survival in Patients with NSCLC on ICIs	90
Aged Lungs Enable Metastatic Outgrowth of Dormant Melanoma Cells	89
What's Next for Sotorasib in NSCLC?	89
Revumenib Is Safe and Efficacious, but MEN1 Mutations Mediate Resistance	89
In This Issue	87
Biomarker Testing Falls Short in NSCLC	87
AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer	85

Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy	85
Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth	84
Noninvasive and Multicancer Biomarkers: The Promise of LINE-1 Retrotransposons	83
Moving Spatially Resolved Multiplexed Protein Profiling toward Clinical Oncology	80
Atypical Small Cell Lung Cancer: A New Malignancy Characterized by Chromothripsis, Carcinoid Tumors, and Wild-type RB1 and TP53	80
Bridging the Gap between Diseases of the Stomach and Lower Esophagus	80
Harnessing Mitochondrial Mutations to ATAC Clonal Evolution in CLL	78
Revealing ARID1A Function in Gastric Cancer from the Bottom Up	78
Beneath the Surface: Neoantigens beyond Chromosomal DNA Mutations	77
New Immunotherapy Combinations Enter the Battlefield of Malignant Mesothelioma	76
Researchers Strive to Refine TMB	76
Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer	74
NRF2: KEAPing Tumors Protected	72
Rlf–Mycl Gene Fusion Drives Tumorigenesis and Metastasis in a Mouse Model of Small Cell Lung Cancer	72
Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity	72
A Molecular Voyage: Multiomics Insights into Circulating Tumor Cells	72
Temozolomide Treatment Alters Mismatch Repair and Boosts Mutational Burden in Tumor and Blood of Colorectal Cancer Patients	72
A Transitional Cell Population Is Enriched in Aggressive Human Medulloblastoma	71
ABBV-383 Demonstrates Tolerability and Efficacy in Relapsed/Refractory MM	71
Distinct Clonal Patterns Exist between Benign and Malignant Tissue	70
Study Sniffs Out New Glioma Mechanism	70
A Spatiotemporal Positive Feedback Loop Exists Between TAMs and CD8+ T Cells	70
Chromatin Remodeling Factors Drive Epigenetic Changes Crucial for T-cell Exhaustion	70
Lasker Honors Discovery of Cell Adhesion Molecules	69
IL6 Blockade Reduces Immunotherapy-Induced Immune-Related Adverse Events	69
Single-Cell Lineage Tracing of Metastasis Uncovers an EMT Continuum	68
Resistant KRAS(G12C) Inhibitor Subclones Exhibit Heterogeneous Alterations	67
Ibrutinib with R-CHOP Differentially Affects Genetic Subtypes of DLBCL	67
Blinatumomab Nonresponse Is Associated with Poor CD19-CAR Outcome in B-ALL	66
Minor Intron Splicing Regulates Hematopoietic Stem Cell Self-Renewal	66
Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors	65
The Kinase Module of the Mediator Complex Inhibits CAR T-cell Function	65
High-Purity CTC RNA Sequencing Identifies Prostate Cancer Lineage Phenotypes Prognostic for Clinical Outcomes	65
MPP8 Silences LINE-1 Retrotransposons to Promote Acute Myeloid Leukemia	65
MCED Testing Enters New Diagnostic Realms	65
MEDI5752 Suppresses Two Immune Checkpoints	64
Cholangiocarcinoma Risk Factors Open the Floodgates for Gut Microbes and Immunosuppressive Myeloid Cells	64
Single-Cell Sequencing Reveals Trajectory of Tumor-Infiltrating Lymphocyte States in Pancreatic Cancer	63
Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia	63
Integrative Analysis of a Large Real-World Cohort of Small Cell Lung Cancer Identifies Distinct Genetic Subtypes and Insights into Histologic Transformation	60
Advancing Global Health Equity in Oncology Clinical Trial Access	60
STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts	60
Sex Hormone Signaling Suppresses Ferroptosis via Phospholipid Remodeling	58
MDM2-PROTAC versus MDM2 Inhibitors: Beyond p53 Reactivation	58
Heritable Defects in Mitotic and Telomere Function Confer Sarcoma Risk	57
Q&A: Robert Vonderheide on Immunotherapy Advances	57
Cancer Cells Adapt to SWI/SNF Inhibition through Compensatory EP400 Function	57
The Hallmarks of Predictive Oncology	56
CD8-Targeted IL2 Unleashes Tumor-Specific Immunity in Human Cancer Tissue by Reviving the Dysfunctional T-cell Pool	56
Cancer Neuroscience of Brain Tumors: From Multicellular Networks to Neuroscience-Instructed Cancer Therapies	56
Air Pollution–Lung Cancer Link Identified	56
Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML	56
Phosphocreatine Promotes Epigenetic Reprogramming to Facilitate Glioblastoma Growth Through Stabilizing BRD2	56
Human Colon Cancer–Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice	55
EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma	55
Acquired Cross-Resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC Paralogs	55
D3S-001, a KRAS G12C Inhibitor with Rapid Target Engagement Kinetics, Overcomes Nucleotide Cycling, and Demonstrates Robust Preclinical and Clinical Activities	55
Anti-Inflammatory Drugs Remodel the Tumor Immune Environment to Enhance Immune Checkpoint Blockade Efficacy	55
Carcinogenic Human Metabolites Are Revealed Using “Metabokiller”	54
CD19/CD20 Bispecific Chimeric Antigen Receptor (CAR) in Naive/Memory T Cells for the Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma	54
MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer	54
Glioma Infiltration and Progression Are Driven by Remote Neuronal Activation	53
Adaptive Evolution: How Bacteria and Cancer Cells Survive Stressful Conditions and Drug Treatment	53
Astronomical Imaging Can Be Used to Analyze Response to Immunotherapy	53
Distinct Treatment-Related Immunologic Biomarkers Are Identified in PDAC	53
Structure of the Ligand-Bound HER2–HER3 Dimer Reveals a Dynamic Interface	52
Silent Mutations Reveal a Novel Treatment for RASQ61 Cancers	52
Surface Expression of NRP1 on Tregs Affects Outcome in Patients with Cancer	52
A Deep Learning Model for Cancer Type Prediction Sets a New Standard	51
ESCRT Protein Inhibition Enhances CTL-Mediated Cytolysis of Tumor Cells	51
Court Rulings Complicate Decisions for Pregnant Patients	51
The Evolutionary History of Breast Cancer and Related Clones Is Revealed	50
VCAM1 Mediates Innate Immune Tolerance of Hematopoietic and Leukemic Stem Cells	50
IL4 Signaling in the Bone Marrow Promotes Protumorigenic Myelopoiesis	50
The CDK4/6 Inhibitor Ribociclib Leads to Stable Disease in Pediatric Cancers	50
Gut Microbiota May Mediate AEs	50
Heterologous Cancer Vaccines plus Checkpoint Inhibitors Show Therapeutic Benefit	49
The APOE–TREM2 Axis Mediates Senescent Neutrophils in Prostate Cancer	49
Antitrust Order Aimed at Equalizing MCED Field	49
Epitope Editing Prevents Off-Tumor Toxicity of CAR T-cell Therapy in AML	48

Peto’s Paradox Is Dead. Long Live Peto’s Paradox	48
Illuminating a Dark Kinase in the Mesenchymal Cancer Cell State	48
Glucose Metabolism in TAMs Promotes Metastasis and Drug Resistance	48
Highlighted Research Articles	48
If You Build It, Patients with Rare Cancers Will Come: A Successful Clinical Trial in Relapsed and Refractory JMML	47
Gene-Specific Machine Learning Models to Classify Driver Mutations in Clonal Hematopoiesis	47
The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade	47
Bacterial Genotoxin Accelerates Transient Infection–Driven Murine Colon Tumorigenesis	47
HeLa Cases Prompt More Thinking on Ethics	46
Tissue-Agnostic Drug Development: A New Path to Drug Approval	46
Sotorasib Tackles KRASG12C-Mutated Pancreatic Cancer	46
Cancer-associated fibroblasts serve as decoys to suppress NK cell anti-cancer cytotoxicity in breast cancer	46
Methylation Is Best for cfDNA Multicancer Early Detection Tests	45
Bone-Induced HER2 Promotes Secondary Metastasis in HR+/HER2− Breast Cancer	45
Stromal KITL/SCF Maintains Pancreas Tissue Homeostasis and Restrains Tumor Progression	45
Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas	45
When Cancer Cells Become the Enablers of an Antitumor Immune Response	45
Tracing Founder Mutations in Circulating and Tissue-Resident Follicular Lymphoma Precursors	45
Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence	44
Combining TIGIT Blockade with MDSC Inhibition Hinders Breast Cancer Bone Metastasis by Activating Antitumor Immunity	44
Combined Inhibition of SHP2 and CXCR1/2 Promotes Antitumor T-cell Response in NSCLC	44
Six-Month Efficacy and Toxicity Profile of BNT162b2 Vaccine in Cancer Patients with Solid Tumors	43
Which Small Molecule? Selecting Chemical Probes for Use in Cancer Research and Target Validation	43
CD137 (4-1BB)-Based Cancer Immunotherapy on Its 25th Anniversary	43
SUV39H1 Ablation Enhances Long-term CAR T Function in Solid Tumors	43
Quantifying the Expanding Landscape of Clinical Actionability for Patients with Cancer	43
A Whole Cancer Cell–Based Vaccine Boosts Cell Killing and Antitumor Immunity	42
Ribosome ADP-Ribosylation Controls Protein Synthesis in Ovarian Cancer	42
DietaryLactobacillus-Derived Exopolysaccharide Enhances Immune-Checkpoint Blockade Therapy	42
Molecular Profiles Distinguish Brain Metastases of Diverse Neural Impact	42
Tumor-Reactive Antibodies Emerge from Nonbinding and Autoreactive Precursors	41
cGAS–STING Pathway Activation in cDCs Underlies TIM3 Blockade Efficacy	41
Specific Anatomic Transcriptomes Drive Oncogenesis in Melanoma	41
A Bacterial-Based Immunotherapy for PDAC	41
Antitumor Plasma Cells Mature Within Tertiary Lymphoid Structures	40
Distinct Mutational Processes Influence Germline DNA Mutations	39
Homing In on RNA Fusions in Breast Cancer	39
TIM3 Blockade in Dendritic Cells May Potentiate Antitumor Immunity	39
ImmunoGen Takeover Caps Year of Record ADC Investments	39
Atypical EGFR Mutations Show Heterogeneity	39
Structure of SHOC2–PP1C–RAS Reveals a Mechanism of RAF Activation	39
In This Issue	38
The Bispecific Antibody Epcoritamab Produces Responses in Lymphoma	38
Culture Media Tweak Makes Heartier CARs	38
Acknowledgment to Reviewers	38
Kidney Cancer Researcher Tapped as NCI Director	38
Clonal GCB Cells Support Angioimmunoblastic T-cell Lymphoma Tumorigenesis	38
A Base Editing Platform Shows Function of Cancer-Associated Variants	38
Acknowledgment to Reviewers	38
HER2 Expression Impacts Trastuzumab Deruxtecan Efficacy in Breast Cancer	37
COVID-19 Vaccines Complicate Mammograms	37
Tumor Microenvironment Immune Changes Support Anti-CD19 CAR T-cell Efficacy	37
Precision Cancer Medicine: Large Studies Indicate Steady Progress	37
Lymphocyte Interaction Networks Drive Lung Cancer Immunosurveillance	37
An Atlas of Tumor Metabolism Uncovers Gene–Metabolite Interactions	37
Cancer-Causative Mutations Occurring in Early Embryogenesis	37
TNF Receptors Choose HSC Fate in SupportingDnmt3a-Mutant Clonal Hematopoiesis	36
Engineering a Next-Gen IL2 Therapy	35
ATM Inhibition Sensitizes ALT Neuroblastomas to Chemotherapy	35
Pushing the Boundaries of Liquid Biopsies for Early Precision Intervention	35
Correction: High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability	35
Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma	35
Biomolecular Condensation: A New Phase in Cancer Research	34
Loss of p53 Induces Tolerance to Viral Mimicry as a Mechanism of Immune Evasion in Early Tumorigenesis	34
DNAJB1-PRKACA Fusion Drives Fibrolamellar Liver Cancer through Impaired SIK Signaling and CRTC2/p300-Mediated Transcriptional Reprogramming	34
IFNα Potentiates Immune-Checkpoint Blockade by Rewiring Metabolic Cross-talk	34
Targeting Acute Myeloid Leukemia Stem Cells through Perturbation of Mitochondrial Calcium	33
Spectrum of Response to Platinum and PARP Inhibitors in Germline BRCA–Associated Pancreatic Cancer in the Clinical and Preclinical Setting	33
So Grateful for My X: Sex Chromosomes Drive Differences in Glioblastoma Immunity	33
Condensate-Promoting ENL Mutation Drives Tumorigenesis In Vivo Through Dynamic Regulation of Histone Modifications and Gene Expression	33
Selective Requirement of MYB for Oncogenic Hyperactivation of a Translocated Enhancer in Leukemia	33
Discovery and Features of an Alkylating Signature in Colorectal Cancer	32
Artificial Intelligence and Machine Learning Technologies in Cancer Care: Addressing Disparities, Bias, and Data Diversity	32
Radical Collaboration: Reimagining Cancer Team Science	32
RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy	32
Single-Cell Tumor–Normal Analysis Proposes Combinatorial CAR Strategies	31
Machine Learning Models ID Cancer Drivers	31
Single-Cell Atlas of Lineage States, Tumor Microenvironment, and Subtype-Specific Expression Programs in Gastric Cancer	31
In This Issue	31
Insights and Opportunity Costs in Applying Spatial Biology to Study the Tumor Microenvironment	31
Altered tRNA Isoacceptor Abundance Regulates Breast Cancer Metastasis	30
Transcriptome Analysis Predicts Treatment Response	30
In This Issue	30
Dual Immunotherapy Makes Strides against HCC	30
Y Chromosome Loss Drives Bladder Cancer Aggressiveness and Immune Evasion	30
Noted	30
Aneuploid Tumor Genomes Undergo Punctuated and Gradual Diversification	29
HSCT Chemotherapy Supports Peripheral Macrophage Engraftment of the Brain	29
Colonic Microbiota Promote Antitumor Immunity in Colorectal Cancer	29
On-Target BTK Mutations Promote Resistance to Noncovalent BTK Inhibitors	29
Approved Drugs May Reduce Anthracycline Drug–Related Cardiotoxicity	28
BTK Inhibitor Options Expand for CLL/SLL	28
MHC-I Cross-Dressing Supports Antitumor CD8+ T-cell Priming	28
A High-Fat Diet Controls MHC Class II on ISCs via the Microbiome	28
Senescent Cancer Cells Are Vulnerable to Extrinsic Apoptosis Pathway Activation	28