Cancer Discovery

Article	Citations
PSMA Expression Is Differentially Regulated across Metastatic Lesions	5494
Cancer-Related Frailty Linked to Cognitive Deficits	981
Tissue-Resident Memory T Cells Underlie Neoadjuvant Immunotherapy Response	608
Structure of the Tumor Stroma Predicts Invasive Breast Cancer Relapse	561
Spatio-Phenotypic Tumor Profiling via Single-Cell 3-D Image Analysis	508
Commensal Bacteria and Fungi Influence Response to Radiation Therapy	399
Erlotinib plus Bevacizumab Is Safe and Effective in EGFR-Mutant NSCLC	352
Drafting a Blueprint for European Cancer Research	350
Leading Oral SERD Shows Prolonged Activity	295
Trastuzumab Deruxtecan Data Impresses at ESMO	246
Collagen Receptor Implicated in Immune Exclusion	227
Genome Doubling Weakens DNA Organization and Supports Tumorigenesis	216
ADCs Inspire $43 Billion Pfizer–Seagen Deal	216
Specific KRAS-Mutant Cancers Are Sensitive to Inhibition of V-type ATPases	206
Adenoviral-Based Cancer Vaccines Promote Anti–PD-1 Treatment Efficacy	192
Early Clones Expand in Richter Transformation of Chronic Lymphocytic Leukemia	186
Cold Exposure Suppresses Tumor Growth through BAT Activation	183
Multicellular Dynamics Associated with Clinical Outcome Were Discovered in PDAC	182
Testing Proton FLASH RT in Bone Mets	180
Noted	177
Urolithin A Induces T Memory Stem Cell Expansion and Antitumor Immunity	174
Sussing Out Adjuvant ICI's Utility in RCC	173
Memory T Cells in Draining Lymph Nodes Potentiate Anti–PD-L1 Therapy	168
GPRC5D CAR T Cells Are Active in BCMA CAR T–Refractory Multiple Myeloma	167
Differential Fungal Mycobiomes Exist between Tumor Types	163

d-2HG Inhibits Effector T Cells by Altering Metabolic Programming	158
Functional reprogramming of neutrophils within the brain tumor microenvironment by hypoxia-driven histone lactylation	155
Tracking Nongenetic Evolution from Primary to Metastatic ccRCC: TRACERx Renal	147
PIN1 Prolyl Isomerase Promotes Initiation and Progression of Bladder Cancer through the SREBP2-Mediated Cholesterol Biosynthesis Pathway	145
Correction: Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer	144
PARADIGM Identifies Associations between Drugs, the Microbiome, and Mortality	142
Highlighted research articles	139
Shattered Chromosomes Undergo Mitotic Tethering during Chromothripsis	138
Simple Hysterectomy Safe for Some Cervical Cancers	135
Senescent Macrophages Promote KRAS-Driven Lung Tumorigenesis	134
A Pan-KRAS Inhibitor Impedes Common KRAS Oncoproteins and Tumor Growth	131
Intratumoral Niches Control CD8+ T-cell Differentiation following ICB	130
Highlighted research articles	126
HLA-E:CD94–NKG2A Mediates Circulating Tumor Cell Immune Evasion	124
Noncanonical Splice Junctions Encode Immunogenic Tumor Neoantigens	121
Scaffolds Improve the Antitumor Activity of Chimeric Antigen Receptors	120
Intermittent Dosing of Milademetan Shows Efficacy and Reduced Toxicity	120
ZBP1 Mediates Replicative Crisis through Telomere-to-Mitochondria Signaling	120
AI-Supported Mammography “Safe,” Cuts Workload	119
CD19 CAR T-cell Clinical Outcome Is Associated with the Gut Microbiome	119
Progression-Free Survival of LM Is Improved by Proton Craniospinal Irradiation	117
Molecular Profiling in Pediatric Cancer Identifies Potential Targeted Therapies	115
Novel Germline Loci Are Associated with Clonal Hematopoiesis Risk	114
To Sleep, Perchance to Metastasize	114
EGFR-Mutant NSCLC: Spotlight on Amivantamab	113
Cilta-cel OK'd for Multiple Myeloma	113
BACE1 Inhibition Stimulates Macrophage Phagocytosis of Glioblastoma Cells	113
TCR Diversity Underpins Immunotherapy Success	112
Down, but Not Out: A Role for SMARCB1 in Synovial Sarcoma	112
Probing Early-Onset Colorectal Cancer	110
Q&A: Philip Greenberg on T Cells, IO's Future	109
F3 Regulates Radiation Therapy–Induced Remodeling and Resistance in Glioblastoma	109
Succinyl-CoA and Cobalamin Are Biomarkers That Improve Anal Cancer Screening	108
Human Tumor Cells Display an Oncogene-like Addiction to Aneuploidy	108
Clonal Cancer Cells Can Give Rise to Diverse Drug Resistant Populations	106
Fecal Microbiota Transplantation plus Anti–PD-1 Is Safe in a First-line Setting	106
Pirtobrutinib Shows Efficacy in Pretreated Chronic Lymphocytic Leukemia	105
Collagen I Homotrimers Promote PDAC Growth and Impact Immunity	104
Mutation-Driven Alveolar Cell Reprogramming Dictates Lung Cancer Progression	104
Assessing Toripalimab in NSCLC	104
Drugs Halt Replication Later than Thought	104
Neutrophil Extracellular Traps Confer Chemoresistance through TGFβ	102
Dendritic Cell Circadian Rhythm Governs the Antitumor Immune Response	98
RAS Drives Malignancy through Altered Stem Cell/Microenvironment Cross-talk	98
Tisagenlecleucel Is Safe and Effective in Relapsed/Refractory Follicular Lymphoma	97
Metabolic Adaptations Alter Metastatic Fitness in Brain-Tropic Breast Cancer	96
FDA Approves First KRAS Inhibitor: Sotorasib	95
Mobocertinib: A Potential Treatment for NSCLC with EGFR Exon 20 Insertions	95
War in Ukraine Disrupts Trials, Cancer Care	94
AACR Project GENIE Biopharma Collaborative Releases Colorectal Cancer Dataset	94

Reforms Urged to Bridge Gender Gaps in Cancer Care	93
ASCL1 and ASCL2 Define Distinct States of Neuroendocrine Prostate Cancer	93
Oral Arsenic Regimen for APL Deemed “Revolutionary”	91
Notch1 Signaling in the White Adipose Tissue Endothelium Promotes Cachexia	89
Probiotic-Guided CAR T cells Promote Antigen-Agnostic Solid Tumor Cytotoxicity	89
CD36 Protects Tumor Cells from Lipotoxicity During Metastasis	88
CAR T-cell Availability for Multiple Myeloma Improving but Still Limited	87
MERCI Predicts Mitochondrial Transfer from T Cells to Tumor Cells	87
Selpercatinib Shifts Treatment Paradigm for MTC and NSCLC	86
Tumoral Lactobacillus iners Induces Therapy Resistance Through Metabolic Rewiring	85
ARPA-H Funds Two Cancer “Manhattan Projects”	85
Transposable Element Signatures Define Stages of T-cell Exhaustion	82
Optimism Surrounds Claudin 18.2 ADC	81
Clinically Actionable Alterations Are Associated with African Ancestry	81
A Single-Cell CRISPR Screen Reveals Intratumoral CD8+ T-cell Fate Regulomes	80
Short-Read Sequencing Detects Large Structural Variants in Cancer Genomes	79
Genomics Sharpens Risk Stratification for Rhabdomyosarcoma	78
Nivolumab Plus Relatlimab Is Safe and Efficacious in Pretreated Melanoma	78
Adjuvant Immunotherapy Best for ctDNA+ Bladder Cancer	77
Tumors Induce Death in Nearby Cells to Gain Competitive Advantage	76
EGFR Inhibitors Synergize with Lenvatinib for Liver Cancer Treatment	75
Low-Glycemic Diets Restrict Tumor Growth through Altered Lipid Metabolism	74
Exome Sequencing IDs Hidden Disease Variants	74
Case Builds for Booster Shots for People with Cancer	74
T Cells Targeting TdT Selectively Kill Leukemic Lymphoblasts	73
Novel SERD Has PFS Edge against Breast Cancer	73
Chromothripsis and Circular Recombination Drive Oncogene Amplification	72
Single-Cell Transcriptomics Reveal Treatment Effects in Prostate Cancer	71
CAR T Cells Activate Cancer Therapy	70
Tumor Profiling Improves Breast Cancer PFS	70
Atezolizumab Extends DFS after NSCLC Relapse	69
Mixed View of “Dangling” Accelerated Approvals	69
RTKs Can Form Membraneless Granules to Drive Cytoplasmic RAS Signaling	69
Durable Responses with Vemurafenib plus Rituximab in Hairy-Cell Leukemia	67
In This Issue	67
NHL Progression Risk Cut with Copanlisib–Rituximab Combo	66
An Oncolytic Coxsackievirus Causes Melanoma Regression with Few Adverse Events	65
Colorectal Cancer Screening to Start at 45	65
Sequencing Tool Sheds New Light on Somatic Mutations	65
Blood Cancers Diminish Response to COVID-19 Vaccine	65
Cell-Intrinsic Programs Partition Nutrients in Tumor Microenvironment	64
COVID-19 Reshapes Cancer Clinical Research	64
Brentuximab Vedotin May Cut Radiation Use in Pediatric Hodgkin Lymphoma	64
Myeloid Cells Counter Immune Suppression	63
Neural Progenitors Promote Malformations in Tuberous Sclerosis Complex	63
BTK Inhibitor May Treat Drug-Resistant CLL, SLL	63
Mouse Models Provide Insight into Factors Affecting BiTE Efficacy	63
NCI Leaders Optimistic about Meeting President’s Goal	63
Efficacy of Immune Checkpoint Inhibitors Is Modulated by Androgen Receptor	62
cBAF Components and MYC Cooperate to Determine CD8+ T-cell Fate Decisions	62
Sharpless Stepping Down as NCI Director	62
Tissue-Resident Memory-like Lymphocytes Demonstrate Effector Activity in Ovarian Cancer	62
Genome-wide Mutation Rate Modeling Identifies Novel Driver Mutations	62
Synthetic Introns Support Targeting of Tumor Cells with Spliceosome Mutations	62
A BCMA-Targeted Bispecific Antibody Is Active in Multiple Myeloma	62
Loss of Tumor Suppressor Genes Is Enriched by the Adaptive Immune System	61
Noted	60
Nuclear Envelope Disruptions Induce DNA Damage and Invasiveness	60
Adjuvant Atezolizumab Holds Its Own in NSCLC	58
Cancer Incidence Drop in 2020 May Not Be Real	57
Normal Skin Mutational Landscapes Reflect Keratinocyte Cancer Incidence	57
Cancer Cells Induce Delayed DNA Breaks to Resist Radiation Therapy	56
Huge Genome Study Uncovers Mutational Signatures	56
Air Pollution Promotes Oncogenic Expansion of Mutant Lung Progenitor Cells	55
Many Unaware of Link between HPV and Some Cancers	55
Probing Microbiome, TLS Dynamics in Tumors	54
Epigenetic Disruption Enables Cancer Cells to Resist Environmental Stress	54
Probing Clonal Hematopoiesis in Liquid Biopsy	54
In This Issue	54
Soluble LAG3 Primes T Cells to Attack NSCLC	54
Single-Agent PD-1 Blockade Is “Treatment of Choice” for Desmoplastic Melanoma	54
GIST: Molecular Profiling Suggests 2nd Therapy	53
FOXA2 Promotes Prostate Cancer Lineage Plasticity through KIT	53
Targeted Therapy Win in BRAF-Mutant Gliomas	52
Tumor-Infiltrating NK Cells Exhibit Tumor Type–Specific Heterogeneity	52
A Trifunctional Natural Killer Cell Engager Can Target CD123+ Leukemia	52
Proteostasis Network Modulation Promotes Resistance to KRAS Inhibitors	52
Enterococcus faecalis Colonization in the Gut Promotes Liver Carcinogenesis	52
Chromosomal Instability Induces Non–Cell-Autonomous Cancer Progression	52
IL7 Genetic Variation Predicts Immune-Related Adverse Events	52

CD300ld on Neutrophils Drives Immune Suppression and Tumor Growth	52
Second Oral SERD Shines in ER+ Breast Cancer	51
Addition of Nintedanib to Neoadjuvant Chemotherapy Is Safe in Bladder Cancer	51
PRODH2-Mediated Proline Metabolism Boosts CAR T-cell Effector Function	51
Infigratinib Approved for Cholangiocarcinoma	50
Telomere Shortening Induces T-cell Dysfunction and Squamous Cell Cancers	50
Patchwork Cancer Predisposition	50
Highlighted Research Articles	50
Gastric Cancer CAR T-cell Target Antigen ID'd	50
Reprogramming Cancer into Antigen-Presenting Cells as a Novel Immunotherapy	49
MonumenTAL Results for Talquetamab in Myeloma	49
A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability	49
T-cell Dysfunction Limits Immunotherapy Efficacy in NASH-Induced Liver Cancer	49
UC Trials Get Standing Ovation	49
apCAFs Are Derived from Mesothelial Cells and Induce Regulatory T Cells	48
CSF2–STAT5 Signaling in TAMs Contributes to CSF1R Inhibition Resistance	48
A Tale of Two Histologies: Dissecting the Biology of Lineage Transformation in Lung Cancer	48
Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer	48
SETD2 Haploinsufficiency Enhances Germinal Center–Associated AICDA Somatic Hypermutation to Drive B-cell Lymphomagenesis	47
REFLECTions on Combination Therapies Empowered by Data Sharing	47
Alpelisib Monotherapy for PI3K-Altered, Pretreated Advanced Breast Cancer: A Phase II Study	47
Adjuvant PD-1 Blockade in Resected Melanoma: Is Preventing Recurrence Enough?	47
Oncogene Convergence in Extrachromosomal DNA Hubs	47
Packing a Punch against PD-L1	47
Colorectal Cancer Genomics by Genetic Ancestry	46
PRC2 Loss and DNMT Inhibition Boost Viral Mimicry in Cancer	46
Sequential Single-Cell Transcriptional and Protein Marker Profiling Reveals TIGIT as a Marker of CD19 CAR-T Cell Dysfunction in Patients with Non-Hodgkin Lymphoma	46
Belly Fat Weakens Immune Fitness	46
LZTR1Mutation Mediates Oncogenesis through Stabilization of EGFR and AXL	45
A Deep Dive into the Circulating ctDNA Cosmos to Vanquish Neuroblastoma	45
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission	44
A Novel Ubiquitin Complex Regulates Aneuploid Epithelial Tumors by Moderating an Integrated Stress Response	44
ADCs or: How I Learned to Stop Worrying and Love Chemotherapy	43
The N6-methyladenosine Epitranscriptomic Landscape of Lung Adenocarcinoma	43
Convergence of Targeted and Immune Therapies for the Treatment of Oncogene-Driven Cancers	43
Fighting the Sixth Decade of the Cancer War with Better Cancer Models	43
Ironing Out the Kinks: Arming Natural Killer Cells against Ovarian Cancer	42
CTR-FAPI PET Enables Precision Management of Medullary Thyroid Carcinoma	42
Combination Diagnostics: Adding Blood-Based ctDNA Screening to Low-Dose CT Imaging for Early Detection of Lung Cancer	41
Heterogeneous HER2 Amplification—a New Clinical Category of HER2-Positive Breast Cancer?	41
Tumor-Intrinsic Kinome Landscape of Pancreatic Cancer Reveals New Therapeutic Approaches	41
Characterization of the Genomic and Immunologic Diversity of Malignant Brain Tumors through Multisector Analysis	41
Paralog Co-Targeting Identifies Selective Genetic Redundancies across Cancer Types	41
Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma	41
Modeling the Landscape of Histone-Mutant Pediatric High-Grade Gliomas: A Study in Partner Alterations	40
Patient-Centric Approaches for Phase I Combination Trials Come on Stage	40
Weighing Antitumor Immunity against Life-threatening Myocarditis from Immune-Checkpoint Inhibitors	40
p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression	39
In Synergy: Optimizing CAR T Development and Personalizing Patient Care Using Single-Cell Technologies	39
A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy	39
Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma	39
Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death	39
Bispecific T-cell Engagers in Metastatic Castration-Resistant Prostate Cancer	38
RAS G12C Inhibitors: Three Birds with One Stone	38
A New Wave of PI3Kα Inhibitors	38
Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression	38
Elucidating the Cell Surfaceome to Accelerate Cancer Drug Development	38
Chemotherapy and the Extra-Tumor Immune Microenvironment: EXTRA-TIME	38
Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations	38
The Promise and Limitations of Neoadjuvant Immune-Checkpoint Blockade in Resectable Non–Small Cell Lung Cancer	38
Mechanisms of Resistance to KRASG12C-Targeted Therapy	37
Cancer Genomes Sometimes Take the Longest Evolutionary Road	37
An NK-cell Therapy for CD30+ Lymphomas	37
Biologic and Clinical Analysis of Childhood Gamma Delta T-ALL Identifies LMO2/STAG2 Rearrangements as Extremely High Risk	37
A Call for Innovative Translational and Clinical Research to Address China’s Unique Cancer Landscape	37
Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer	37
PD-1 Blockade Falls Short (Repeatedly) in Prostate Cancer	36
FDA Gives Nod to T-DXd for HER2-Mutant NSCLC	36
RB/E2F1 as a Master Regulator of Cancer Cell Metabolism in Advanced Disease	36
Correction: Hypoxia Induces Phenotypic Plasticity and Therapy Resistance in Melanoma via the Tyrosine Kinase Receptors ROR1 and ROR2	36
Natural Coevolution of Tumor and Immunoenvironment in Glioblastoma	35
Highlighted research articles	35
Cytosolic Phospholipase A2 determines Intercellular Heterogeneity of Stress Granules and Chemotherapy Response	35
Correction: Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis	35
Expression of Concern: Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Antitumor T-cell Immunity	35
The 3D Revolution in Cancer Discovery	34
Prolonged SARS-CoV-2 Infection in Patients with Lymphoid Malignancies	34
A Cell-Surface MHC-I Inhibitory Axis Promotes Immune Evasion in Cancer	34
Hotspot Mutations Optimize the Oncogenic–Immunogenic Trade-off	34
A Proposed Framework and Lexicon for Cancer Prevention	34
Lymph Node Metastasis Induces Immune Tolerance and Distant Metastasis	33
HPV Integration Can Drive the Formation of Virus–Host Extrachromosomal DNA in Tumors	33
Trispecifics Improve Immune-Cell Engagement	33
INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors	32
Highly Multiplexed Tissue Imaging in Precision Oncology and Translational Cancer Research	32
Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia	32
Androgen Receptor Inhibition Increases MHC Class I Expression and Improves Immune Response in Prostate Cancer	32
GPR65 Inactivation in Tumor Cells Drives Antigen-Independent CAR T-cell Resistance via Macrophage Remodeling	31
TREX1 Inactivation Unleashes Cancer Cell STING–Interferon Signaling and Promotes Antitumor Immunity	31
Biomarkers Associating with PARP Inhibitor Benefit in Prostate Cancer in the TOPARP-B Trial	31
IFNα Potentiates Anti–PD-1 Efficacy by Remodeling Glucose Metabolism in the Hepatocellular Carcinoma Microenvironment	31
Late-Stage Metastatic Melanoma Emerges through a Diversity of Evolutionary Pathways	30
Context-Specific Determinants of the Immunosuppressive Tumor Microenvironment in Pancreatic Cancer	30
Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma	30
Think Globally, Act Locally: Globalizing Precision Oncology	30