Cancer Discovery

Article	Citations
Drafting a Blueprint for European Cancer Research	367
Highlighted research articles	350
Q&A: Philip Greenberg on T Cells, IO's Future	328
AI-Supported Mammography “Safe,” Cuts Workload	318
Mutation-Driven Alveolar Cell Reprogramming Dictates Lung Cancer Progression	301
Succinyl-CoA and Cobalamin Are Biomarkers That Improve Anal Cancer Screening	300
Human Tumor Cells Display an Oncogene-like Addiction to Aneuploidy	258
Probing Clonal Hematopoiesis in Liquid Biopsy	251
Shattered Chromosomes Undergo Mitotic Tethering during Chromothripsis	211
PARADIGM Identifies Associations between Drugs, the Microbiome, and Mortality	208
Highlighted research articles	206
Proteostasis Network Modulation Promotes Resistance to KRAS Inhibitors	204
RAS Drives Malignancy through Altered Stem Cell/Microenvironment Cross-talk	202
IL7 Genetic Variation Predicts Immune-Related Adverse Events	195
Convergence of Targeted and Immune Therapies for the Treatment of Oncogene-Driven Cancers	189
Reversing Immune Aging to Improve Immunotherapy Outcomes	188
Disrupting MYC RNA Interactions Promotes Tumor Regression	180
GIST: Molecular Profiling Suggests 2nd Therapy	172
Transposable Element Signatures Define Stages of T-cell Exhaustion	165
Correction: Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer	159
Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma	156
Air Pollution Promotes Oncogenic Expansion of Mutant Lung Progenitor Cells	155
Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta	154
Selpercatinib Shifts Treatment Paradigm for MTC and NSCLC	153
Liver Response to Metabolic Stress Drives Cancer-associated Programs	153

Combination Diagnostics: Adding Blood-Based ctDNA Screening to Low-Dose CT Imaging for Early Detection of Lung Cancer	153
HLA-E:CD94–NKG2A Mediates Circulating Tumor Cell Immune Evasion	152
Rational Protein Engineering to Enhance MHC-Independent T-cell Receptors	149
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission	149
Cytosolic Phospholipase A2 Determines Intercellular Heterogeneity of Stress Granules and Chemotherapy Response	147
Modular Platform Curbs CAR T-Cell Exhaustion by Tuning Receptor Shedding	144
Dendritic Cell Circadian Rhythm Governs the Antitumor Immune Response	138
A Guide to Extrachromosomal DNA: Cancer’s Dynamic Circular Genome	134
Nonprofit Acquires Abandoned Leukemia Drug Supply	133
A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy	131
PIN1 Prolyl Isomerase Promotes Initiation and Progression of Bladder Cancer through the SREBP2-Mediated Cholesterol Biosynthesis Pathway	130
p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression	128
CHD2 Regulates Neuron–Glioma Interactions in Pediatric Glioma	128
Circulating Tumor Cells Predict Response to the DLL3-Targeting Bispecific Antibody Tarlatamab	123
Intrinsic Properties of the Lymph Node Render It Immunologically Susceptible to Metastasis	123
The 3D Revolution in Cancer Discovery	121
The Dark Side of NK Cells in Cancer Immunotherapy	121
Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression	120
Therapy-Related Mutational Signatures in Subsequent Neoplasms among Survivors of Childhood Cancer	119
Longitudinal Plasma Metabolomics Guides Dynamic Risk Assessment and Dietary Modulation for Esophageal Squamous Cell Cancer Chemoimmunotherapy	118
Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma	117
Gut Microbiota Modulation through Akkermansia spp . Supplementation Increases CAR T-cell Potency	116
Presurgery Plus Postsurgery Immunotherapy Ups Survival in NSCLC	115
New Strategy May Thwart Glioblastoma Resistance	113
FMRP Depletion Reprograms an Immunosuppressive Microenvironment	111
The Proteasome Regulator PSME4 Modulates Antitumor Immunity	111
Chronic Inflammation Drives TP53-Mutant Leukemic Evolution	110
Tumor-Derived Extracellular Vesicles and Particles Inhibit Liver Function	110
Multicellular Spatial Organization Determines Immunotherapy Response	109
Revumenib Is Safe and Efficacious, but MEN1 Mutations Mediate Resistance	108
What's Next for Sotorasib in NSCLC?	103
Aged Lungs Enable Metastatic Outgrowth of Dormant Melanoma Cells	103
Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Protumorigenic T-cell Polarization	102
Moving Spatially Resolved Multiplexed Protein Profiling toward Clinical Oncology	101
TILs Outperform Ipilimumab in Melanoma	99
In This Issue	99
Hyperactivation of Oncogenic Pathways Hinders Cancer Cell Survival	97
Lymph Node–Specific IFNγ Levels Affect CD8+ T-cell Priming against Tumors	97
Bridging the Gap between Diseases of the Stomach and Lower Esophagus	96
Landmark Pediatric Cancer Legislation Aims to Incentivize Research	96
Noninvasive and Multicancer Biomarkers: The Promise of LINE-1 Retrotransposons	96
Beneath the Surface: Neoantigens beyond Chromosomal DNA Mutations	95
Cancer in the Prime of Life: Etiologic Insights and Supportive Oncologic Interventions for the Rising Burden of Young Adult Cancer	94
Multimodal AI Model Predicts Breast Cancer Recurrence	93
Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy	92
A Molecular Voyage: Multiomics Insights into Circulating Tumor Cells	91
Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer	90
Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity	88
mtDNA Lineage Tracing Reveals Monocyte Fate Bias Prior to Tumor Infiltration	86
Myofibroblasts Induce Neuroplasticity to Promote Pancreatic Inflammation and Cancer Progression	85

Atypical Small Cell Lung Cancer: A New Malignancy Characterized by Chromothripsis, Carcinoid Tumors, and Wild-type RB1 and TP53	85
Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth	85
A pan-cancer single-cell analysis of intratumoral copy number diversity and evolution	85
EML4-ALK mediates resistance to KRAS G12C inhibition and induces an oncogenic dependency by rewiring signaling through the wild-type RAS pathway	84
The Kinase Module of the Mediator Complex Inhibits CAR T-cell Function	82
The Moving Target: Cis -Mutation–Driven Resistance to p53-Y220C Reactivator	82
MCED Testing Enters New Diagnostic Realms	79
Distinct Clonal Patterns Exist between Benign and Malignant Tissue	78
Chromatin Remodeling Factors Drive Epigenetic Changes Crucial for T-cell Exhaustion	78
Heritable Defects in Mitotic and Telomere Function Confer Sarcoma Risk	77
Lasker Honors Discovery of Cell Adhesion Molecules	77
ABBV-383 Demonstrates Tolerability and Efficacy in Relapsed/Refractory MM	77
The Hallmarks of Predictive Oncology	76
CD19/CD20 Bispecific Chimeric Antigen Receptor (CAR) in Naive/Memory T Cells for the Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma	76
Q&A: Robert Vonderheide on Immunotherapy Advances	76
Air Pollution–Lung Cancer Link Identified	74
Advancing Global Health Equity in Oncology Clinical Trial Access	74
Phosphocreatine Promotes Epigenetic Reprogramming to Facilitate Glioblastoma Growth Through Stabilizing BRD2	74
A Transitional Cell Population Is Enriched in Aggressive Human Medulloblastoma	73
Highlighted Research Articles	73
Cancer Cells Adapt to SWI/SNF Inhibition through Compensatory EP400 Function	73
Prenatal Chemotherapy and Its Impact on the Genome of Fetal Hematopoiesis	72
Sex Hormone Signaling Suppresses Ferroptosis via Phospholipid Remodeling	72
D3S-001, a KRAS G12C Inhibitor with Rapid Target Engagement Kinetics, Overcomes Nucleotide Cycling, and Demonstrates Robust Preclinical and Clinical Activities	71
Epigenetic Regulation of Chromosomal Instability by EZH2 Methyltransferase	70
Oncogenic and Tumor-Suppressive Events Act on a Progenitor State to Promote or Prevent Malignancy	70
Integrative Analysis of a Large Real-World Cohort of Small Cell Lung Cancer Identifies Distinct Genetic Subtypes and Insights into Histologic Transformation	70
Acquisition of Centromeric Features Supports Telomere Integrity	70
MDM2-PROTAC versus MDM2 Inhibitors: Beyond p53 Reactivation	68
MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP -Deleted Cancer	68
STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts	68
Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia	64
Cancer Neuroscience of Brain Tumors: From Multicellular Networks to Neuroscience-Instructed Cancer Therapies	64
Study Sniffs Out New Glioma Mechanism	64
Pancreatic Cancer: Translating Tumor Biology into Actionability	64
A Plastic EMP1+ to LGR5+ Cell State Conversion as a Bypass to KRASG12D Pharmacologic Inhibition in Metastatic Colorectal Cancer	64
Acquired Cross-Resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC Paralogs	63
Impact of vitamin D on the colon cancer immune microenvironment: results of a randomized clinical trial of preoperative vitamin D supplementation in patients with stage I-III colon cancer	63
High-Purity CTC RNA Sequencing Identifies Prostate Cancer Lineage Phenotypes Prognostic for Clinical Outcomes	62
Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibit	62
CD8-Targeted IL2 Unleashes Tumor-Specific Immunity in Human Cancer Tissue by Reviving the Dysfunctional T-cell Pool	62
Glioma Infiltration and Progression Are Driven by Remote Neuronal Activation	61
Court Rulings Complicate Decisions for Pregnant Patients	60
Antitrust Order Aimed at Equalizing MCED Field	59
Carcinogenic Human Metabolites Are Revealed Using “Metabokiller”	59
IL4 Signaling in the Bone Marrow Promotes Protumorigenic Myelopoiesis	59
Heterologous Cancer Vaccines plus Checkpoint Inhibitors Show Therapeutic Benefit	57
The Evolutionary History of Breast Cancer and Related Clones Is Revealed	57
Epitope Editing Prevents Off-Tumor Toxicity of CAR T-cell Therapy in AML	57
The APOE–TREM2 Axis Mediates Senescent Neutrophils in Prostate Cancer	57
Highlighted Research Articles	57
Glucose Metabolism in TAMs Promotes Metastasis and Drug Resistance	57
Clonal Hematopoiesis Enhances Immunotherapy Response in Solid Tumors	56
Methylation Is Best for cfDNA Multicancer Early Detection Tests	56
HeLa Cases Prompt More Thinking on Ethics	56
Tumor-infiltrating Bacteria Induce Quiescence and Therapy Resistance	55
Intra- Versus Extracellular Bacteria Dictate Tumor Immunity and Metastatic Recurrence	55
Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection—Letter	54
The Bitter Aftertaste of Artificial Sweeteners in Cancer Immunotherapy	54
Peto’s Paradox Is Dead. Long Live Peto’s Paradox	53
Spatially Defined Cellular Niches Forged by Tumor-Intrinsic MHCII Redefine Immune Competence in Ovarian Cancer	53
If You Build It, Patients with Rare Cancers Will Come: A Successful Clinical Trial in Relapsed and Refractory JMML	53
A Deep Learning Model for Cancer Type Prediction Sets a New Standard	52
Gene-Specific Machine Learning Models to Classify Driver Mutations in Clonal Hematopoiesis	52
Illuminating a Dark Kinase in the Mesenchymal Cancer Cell State	51
Stromal KITL/SCF Maintains Pancreas Tissue Homeostasis and Restrains Tumor Progression	51
Winning Cancer Grand Challenges Teams Announced	49
Niche Labeling Reveals Pro-Metastatic Immune-Cancer Cell Interactions	49
The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer	49
When Cancer Cells Become the Enablers of an Antitumor Immune Response	49
Bone-Induced HER2 Promotes Secondary Metastasis in HR+/HER2− Breast Cancer	48
Which Small Molecule? Selecting Chemical Probes for Use in Cancer Research and Target Validation	48
Catalytic Inhibition of KAT6/KAT7 Enhances the Efficacy and Overcomes Primary and Acquired Resistance to Menin Inhibitors in MLL Leukemia	48
CD137 (4-1BB)-Based Cancer Immunotherapy on Its 25th Anniversary	48
White House Proposes Cuts to NIH Funding for FY27	47
Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas	47
Tracing Founder Mutations in Circulating and Tissue-Resident Follicular Lymphoma Precursors	46
Spatial Mapping of the Precancer-to-Cancer Transition in Breast and Prostate	46
Highlighted Research Articles	46
The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade	45

Germline CDK12 variants in aggressive prostate cancer	45
Cancer-Associated Fibroblasts Serve as Decoys to Suppress NK Cell Anticancer Cytotoxicity in Breast Cancer	45
Arachidonic Acid Metabolism in PMN-MDSCs Suppresses Antitumor Capacity of T Cells in KRAS -Mutant Cholangiocarcinoma	45
SUV39H1 Ablation Enhances Long-term CAR T Function in Solid Tumors	45
Quantifying the Expanding Landscape of Clinical Actionability for Patients with Cancer	45
A Whole Cancer Cell–Based Vaccine Boosts Cell Killing and Antitumor Immunity	44
Homing In on RNA Fusions in Breast Cancer	44
Combining TIGIT Blockade with MDSC Inhibition Hinders Breast Cancer Bone Metastasis by Activating Antitumor Immunity	44
ImmunoGen Takeover Caps Year of Record ADC Investments	44
A High-Fiber, Plant-Based Diet in Myeloma Precursor Disorders: Results from the NUTRIVENTION Clinical Trial and Preclinical Vk*MYC Model	44
Molecular Profiles Distinguish Brain Metastases of Diverse Neural Impact	43
Tumor Microenvironment Immune Changes Support Anti-CD19 CAR T-cell Efficacy	43
Kidney Cancer Researcher Tapped as NCI Director	43
Culture Media Tweak Makes Heartier CARs	42
Lymphocyte Interaction Networks Drive Lung Cancer Immunosurveillance	42
Acknowledgment to Reviewers	42
HER2 Expression Impacts Trastuzumab Deruxtecan Efficacy in Breast Cancer	42
An Atlas of Tumor Metabolism Uncovers Gene–Metabolite Interactions	42
Highlighted Research Articles	41
Insights and Opportunity Costs in Applying Spatial Biology to Study the Tumor Microenvironment	41
Clonal GCB Cells Support Angioimmunoblastic T-cell Lymphoma Tumorigenesis	41
So Grateful for My X: Sex Chromosomes Drive Differences in Glioblastoma Immunity	40
Loss of p53 Induces Tolerance to Viral Mimicry as a Mechanism of Immune Evasion in Early Tumorigenesis	40
RNA-Triggered Chromatin Shredding Hits Cancer’s Hardest Targets	39
Spectrum of Response to Platinum and PARP Inhibitors in Germline BRCA –Associated Pancreatic Cancer in the Clinical and Preclinical Setting	39
TNF Receptors Choose HSC Fate in Supporting Dnmt3a -Mutant Clonal Hematopoiesis	39
Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma	39
Pushing the Boundaries of Liquid Biopsies for Early Precision Intervention	39
Targeting Acute Myeloid Leukemia Stem Cells through Perturbation of Mitochondrial Calcium	38
Chemically Induced Skin Tumors Arise from Upper Hair Follicle Stem Cells	38
Single-Cell Spatial Atlas of High-Grade Serous Ovarian Cancer Uncovers MHC Class II as a Key Predictor of Spatial Tumor Ecosystems and Clinical Outcomes	38
Radical Collaboration: Reimagining Cancer Team Science	38
Single-Cell Tumor–Normal Analysis Proposes Combinatorial CAR Strategies	37
DNAJB1-PRKACA Fusion Drives Fibrolamellar Liver Cancer through Impaired SIK Signaling and CRTC2/p300-Mediated Transcriptional Reprogramming	37
Brain Network Connectivity Predicts Survival in Diffuse Midline Glioma	37
Condensate-Promoting ENL Mutation Drives Tumorigenesis In Vivo Through Dynamic Regulation of Histone Modifications and Gene Expression	37
Toward AI-Powered Cancer Etiology Research	37
BTK Inhibitor Options Expand for CLL/SLL	36
Senescent Cancer Cells Are Vulnerable to Extrinsic Apoptosis Pathway Activation	36
In This Issue	35
Altered tRNA Isoacceptor Abundance Regulates Breast Cancer Metastasis	35
Driver Events of Gastric Cancer Differ According to Subtype and Ancestry	35
High-Endothelial Venules Promote Permissive T-cell Niches after Immunotherapy	35
Disruption of KAT8–IRF1 Condensate Formation Reduces PD-L1 Expression	34
Intrinsically Disordered Regions Control cBAF Condensation and Interactions	34
PHGDH Inhibition Overcomes Glioblastoma Resistance to T-cell Therapy	34
Gut Microbiota Regulate PD-L2 Expression and Immunotherapy Response	34
Artificial Intelligence Identifies Novel Disease Pathways	34
Nociceptor Neurons Affect Immunosurveillance and Tumor Growth	34
Primary, Metastatic Tumors Vary Genomically by Cancer Type	34
HPV42, a “Low-Risk” Type, and Digital Papillary Adenocarcinoma	33
Tackling Cancer through Global Team Science	32
Personalized mRNA Vaccine Spurs Lasting Immunity in TNBC	32
Correction: Creating MHC-Restricted Neoantigens with Covalent Inhibitors That Can Be Targeted by Immune Therapy	32
Dangerous Liaisons between Tet2 Mutation, Inflammatory Monocytes, and Leukemogenesis	32
Targeting Exposed Phosphatidylserine Boosts Antigen-Specific T-Cell Response	31
Correction: Highlights of FDA Oncology Approvals in 2023: Bispecific T-cell Engagers, Pediatric Indications, and Inclusive Drug Development	31
Cancer Throughlines: 40 Years After Chernobyl Disaster, Research on Cancer Impact Carries On	31
Correction: Animal Alternatives OK'd by New Law	31
Glucocorticoid Receptor Antagonist Approved for Ovarian Cancer	30
A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas	29
Micronuclei and Cancer	29
Y Chromosome Loss Drives Bladder Cancer Aggressiveness and Immune Evasion	29
GLP-1 RAs May Prevent Metastatic Progression	29
Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants	29
Germline–Somatic Liaison Dictates Cancer Subtypes via de novo Steroid Biosynthesis	28
Mitochondrial Glutathione Import Enables Breast Cancer Metastasis via Integrated Stress Response Signaling	28
Cell States in Cancer: Drivers, Passengers, and Trailers	27
Receptor-interacting Protein Kinase 2 Is an Immunotherapy Target in Pancreatic Cancer	27
A New Class of Molecular Glues: Double Allostery Restores KEAP1 Control of NRF2	27
Lung Tumors Hack Nervous System to Drive Cachexia	27
Sensitizing Lung Cancer to Immunotherapy with a RAS(ON) Inhibitor Doublet	27
The SCRUM-MONSTAR Cancer-Omics Ecosystem: Striving for a Quantum Leap in Precision Medicine	27
Immunogenicity and Efficacy of Personalized Adjuvant mRNA Cancer Vaccines	27
LINE-1 Locus Transcription Nucleates Oncogenic Chromatin Architecture	27
Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer	26
Noninvasive Detection of Neuroendocrine Prostate Cancer through Targeted Cell-free DNA Methylation	26
Senescence Defines a Distinct Subset of Myofibroblasts That Orchestrates Immunosuppression in Pancreatic Cancer	26
The Origin of Highly Elevated Cell-Free DNA in Healthy Individuals and Patients with Pancreatic, Colorectal, Lung, or Ovarian Cancer	25
Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection	25
FOXA2 Promotes Prostate Cancer Lineage Plasticity through KIT	25
Intratumoral Niches Control CD8+ T-cell Differentiation following ICB	25
A Trifunctional Natural Killer Cell Engager Can Target CD123+ Leukemia	25
Leading Oral SERD Shows Prolonged Activity	25
GPRC5D CAR T Cells Are Active in BCMA CAR T–Refractory Multiple Myeloma	25
Noted	25
Noted	25
Chromosomal Instability Induces Non–Cell-Autonomous Cancer Progression	24
Early Clones Expand in Richter Transformation of Chronic Lymphocytic Leukemia	24
ZBP1 Mediates Replicative Crisis through Telomere-to-Mitochondria Signaling	24
Clinically Actionable Alterations Are Associated with African Ancestry	24
Cold Exposure Suppresses Tumor Growth through BAT Activation	24
Nivolumab Plus Relatlimab Is Safe and Efficacious in Pretreated Melanoma	23
In This Issue	23
Expression of Concern: Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Antitumor T-cell Immunity	23