Cancer Discovery

Article	Citations
Drafting a Blueprint for European Cancer Research	334
Highlighted research articles	327
Q&A: Philip Greenberg on T Cells, IO's Future	283
AI-Supported Mammography “Safe,” Cuts Workload	277
Mutation-Driven Alveolar Cell Reprogramming Dictates Lung Cancer Progression	258
Succinyl-CoA and Cobalamin Are Biomarkers That Improve Anal Cancer Screening	256
Human Tumor Cells Display an Oncogene-like Addiction to Aneuploidy	232
Probing Clonal Hematopoiesis in Liquid Biopsy	219
Shattered Chromosomes Undergo Mitotic Tethering during Chromothripsis	197
PARADIGM Identifies Associations between Drugs, the Microbiome, and Mortality	193
Highlighted research articles	182
An NK-cell Therapy for CD30+ Lymphomas	178
Proteostasis Network Modulation Promotes Resistance to KRAS Inhibitors	178
Trispecifics Improve Immune-Cell Engagement	178
Lymph Node Metastasis Induces Immune Tolerance and Distant Metastasis	172
RAS Drives Malignancy through Altered Stem Cell/Microenvironment Cross-talk	165
IL7 Genetic Variation Predicts Immune-Related Adverse Events	163
Convergence of Targeted and Immune Therapies for the Treatment of Oncogene-Driven Cancers	161
REFLECTions on Combination Therapies Empowered by Data Sharing	156
Reversing Immune Aging to Improve Immunotherapy Outcomes	149
Disrupting MYC RNA Interactions Promotes Tumor Regression	147
GIST: Molecular Profiling Suggests 2nd Therapy	142
Cytosolic Phospholipase A2 Determines Intercellular Heterogeneity of Stress Granules and Chemotherapy Response	142
Transposable Element Signatures Define Stages of T-cell Exhaustion	141
Correction: Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer	140

The Dark Side of NK Cells in Cancer Immunotherapy	139
The 3D Revolution in Cancer Discovery	139
Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma	136
Dendritic Cell Circadian Rhythm Governs the Antitumor Immune Response	132
Liver Response to Metabolic Stress Drives Cancer-associated Programs	128
Intrinsic Properties of the Lymph Node Render It Immunologically Susceptible to Metastasis	128
HLA-E:CD94–NKG2A Mediates Circulating Tumor Cell Immune Evasion	126
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission	125
Longitudinal Plasma Metabolomics Guides Dynamic Risk Assessment and Dietary Modulation for Esophageal Squamous Cell Cancer Chemoimmunotherapy	124
Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta	123
Selpercatinib Shifts Treatment Paradigm for MTC and NSCLC	122
PIN1 Prolyl Isomerase Promotes Initiation and Progression of Bladder Cancer through the SREBP2-Mediated Cholesterol Biosynthesis Pathway	117
Combination Diagnostics: Adding Blood-Based ctDNA Screening to Low-Dose CT Imaging for Early Detection of Lung Cancer	116
A Guide to Extrachromosomal DNA: Cancer’s Dynamic Circular Genome	115
Rational Protein Engineering to Enhance MHC-Independent T-cell Receptors	115
Therapy-related mutational signatures in subsequent neoplasms among survivors of childhood cancer	114
Air Pollution Promotes Oncogenic Expansion of Mutant Lung Progenitor Cells	112
CHD2 Regulates Neuron–Glioma Interactions in Pediatric Glioma	111
Gut Microbiota Modulation through Akkermansia spp . Supplementation Increases CAR T-cell Potency	109
Circulating Tumor Cells Predict Response to the DLL3-Targeting Bispecific Antibody Tarlatamab	109
A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy	109
Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression	108
p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression	108
Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma	107
Presurgery Plus Postsurgery Immunotherapy Ups Survival in NSCLC	106
New Strategy May Thwart Glioblastoma Resistance	105
FMRP Depletion Reprograms an Immunosuppressive Microenvironment	104
The Proteasome Regulator PSME4 Modulates Antitumor Immunity	102
Tumor-Derived Extracellular Vesicles and Particles Inhibit Liver Function	101
Multicellular Spatial Organization Determines Immunotherapy Response	98
Chronic Inflammation Drives TP53-Mutant Leukemic Evolution	98
Revumenib Is Safe and Efficacious, but MEN1 Mutations Mediate Resistance	98
Aged Lungs Enable Metastatic Outgrowth of Dormant Melanoma Cells	96
What's Next for Sotorasib in NSCLC?	96
Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Protumorigenic T-cell Polarization	94
Moving Spatially Resolved Multiplexed Protein Profiling toward Clinical Oncology	93
In This Issue	92
TILs Outperform Ipilimumab in Melanoma	92
Lymph Node–Specific IFNγ Levels Affect CD8+ T-cell Priming against Tumors	91
Hyperactivation of Oncogenic Pathways Hinders Cancer Cell Survival	91
Temozolomide Treatment Alters Mismatch Repair and Boosts Mutational Burden in Tumor and Blood of Colorectal Cancer Patients	91
A Molecular Voyage: Multiomics Insights into Circulating Tumor Cells	90
Myofibroblasts Induce Neuroplasticity to Promote Pancreatic Inflammation and Cancer Progression	89
Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity	89
Beneath the Surface: Neoantigens beyond Chromosomal DNA Mutations	88
Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy	87
Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer	87
Noninvasive and Multicancer Biomarkers: The Promise of LINE-1 Retrotransposons	87
Atypical Small Cell Lung Cancer: A New Malignancy Characterized by Chromothripsis, Carcinoid Tumors, and Wild-type RB1 and TP53	86
Multimodal AI Model Predicts Breast Cancer Recurrence	86

Bridging the Gap between Diseases of the Stomach and Lower Esophagus	86
The Moving Target: Cis -Mutation–Driven Resistance to p53-Y220C Reactivator	84
Cancer in the Prime of Life: Etiologic Insights and Supportive Oncologic Interventions for the Rising Burden of Young Adult Cancer	84
Landmark Pediatric Cancer Legislation Aims to Incentivize Research	84
Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth	83
AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer	83
MCED Testing Enters New Diagnostic Realms	81
The Kinase Module of the Mediator Complex Inhibits CAR T-cell Function	81
Chromatin Remodeling Factors Drive Epigenetic Changes Crucial for T-cell Exhaustion	79
Study Sniffs Out New Glioma Mechanism	79
A Spatiotemporal Positive Feedback Loop Exists Between TAMs and CD8+ T Cells	79
Distinct Clonal Patterns Exist between Benign and Malignant Tissue	78
Lasker Honors Discovery of Cell Adhesion Molecules	76
ABBV-383 Demonstrates Tolerability and Efficacy in Relapsed/Refractory MM	76
Heritable Defects in Mitotic and Telomere Function Confer Sarcoma Risk	75
Q&A: Robert Vonderheide on Immunotherapy Advances	75
Sex Hormone Signaling Suppresses Ferroptosis via Phospholipid Remodeling	74
Air Pollution–Lung Cancer Link Identified	73
Cancer Cells Adapt to SWI/SNF Inhibition through Compensatory EP400 Function	72
Highlighted Research Articles	72
Single-Cell Sequencing Reveals Trajectory of Tumor-Infiltrating Lymphocyte States in Pancreatic Cancer	71
A Transitional Cell Population Is Enriched in Aggressive Human Medulloblastoma	71
Epigenetic Regulation of Chromosomal Instability by EZH2 Methyltransferase	71
IL6 Blockade Reduces Immunotherapy-Induced Immune-Related Adverse Events	70
MEDI5752 Suppresses Two Immune Checkpoints	69
MDM2-PROTAC versus MDM2 Inhibitors: Beyond p53 Reactivation	69
Phosphocreatine Promotes Epigenetic Reprogramming to Facilitate Glioblastoma Growth Through Stabilizing BRD2	68
D3S-001, a KRAS G12C Inhibitor with Rapid Target Engagement Kinetics, Overcomes Nucleotide Cycling, and Demonstrates Robust Preclinical and Clinical Activities	68
Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibit	67
CD8-Targeted IL2 Unleashes Tumor-Specific Immunity in Human Cancer Tissue by Reviving the Dysfunctional T-cell Pool	67
A Plastic EMP1+ to LGR5+ Cell State Conversion as a Bypass to KRASG12D Pharmacologic Inhibition in Metastatic Colorectal Cancer	67
Prenatal Chemotherapy and Its Impact on the Genome of Fetal Hematopoiesis	67
High-Purity CTC RNA Sequencing Identifies Prostate Cancer Lineage Phenotypes Prognostic for Clinical Outcomes	66
MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP -Deleted Cancer	66
The Hallmarks of Predictive Oncology	66
STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts	65
Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia	65
Advancing Global Health Equity in Oncology Clinical Trial Access	64
Integrative Analysis of a Large Real-World Cohort of Small Cell Lung Cancer Identifies Distinct Genetic Subtypes and Insights into Histologic Transformation	64
Human Colon Cancer–Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice	63
Acquired Cross-Resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC Paralogs	63
Cancer Neuroscience of Brain Tumors: From Multicellular Networks to Neuroscience-Instructed Cancer Therapies	63
CD19/CD20 Bispecific Chimeric Antigen Receptor (CAR) in Naive/Memory T Cells for the Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma	62
Glioma Infiltration and Progression Are Driven by Remote Neuronal Activation	61
Court Rulings Complicate Decisions for Pregnant Patients	61
IL4 Signaling in the Bone Marrow Promotes Protumorigenic Myelopoiesis	60
Carcinogenic Human Metabolites Are Revealed Using “Metabokiller”	59
The Evolutionary History of Breast Cancer and Related Clones Is Revealed	57
Antitrust Order Aimed at Equalizing MCED Field	57
Distinct Treatment-Related Immunologic Biomarkers Are Identified in PDAC	57
Heterologous Cancer Vaccines plus Checkpoint Inhibitors Show Therapeutic Benefit	56
The APOE–TREM2 Axis Mediates Senescent Neutrophils in Prostate Cancer	56
Glucose Metabolism in TAMs Promotes Metastasis and Drug Resistance	56
HeLa Cases Prompt More Thinking on Ethics	55
Epitope Editing Prevents Off-Tumor Toxicity of CAR T-cell Therapy in AML	55
Highlighted Research Articles	55
When Cancer Cells Become the Enablers of an Antitumor Immune Response	54
Clonal Hematopoiesis Enhances Immunotherapy Response in Solid Tumors	54
Methylation Is Best for cfDNA Multicancer Early Detection Tests	54
The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer	52
Tracing Founder Mutations in Circulating and Tissue-Resident Follicular Lymphoma Precursors	52
Tumor-infiltrating Bacteria Induce Quiescence and Therapy Resistance	52
Intra- Versus Extracellular Bacteria Dictate Tumor Immunity and Metastatic Recurrence	52
Arachidonic Acid Metabolism in PMN-MDSCs Suppresses Antitumor Capacity of T cells in KRAS-Mutant Cholangiocarcinoma	51
The Bitter Aftertaste of Artificial Sweeteners in Cancer Immunotherapy	51
If You Build It, Patients with Rare Cancers Will Come: A Successful Clinical Trial in Relapsed and Refractory JMML	50
Winning Cancer Grand Challenges Teams Announced	50
Peto’s Paradox Is Dead. Long Live Peto’s Paradox	50
Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection—Letter	50
Gene-Specific Machine Learning Models to Classify Driver Mutations in Clonal Hematopoiesis	50
White House Proposes Cuts to NIH Funding for FY27	50
Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence	50
A Deep Learning Model for Cancer Type Prediction Sets a New Standard	49
Catalytic Inhibition of KAT6/KAT7 Enhances the Efficacy and Overcomes Primary and Acquired Resistance to Menin Inhibitors in MLL Leukemia	49
CD137 (4-1BB)-Based Cancer Immunotherapy on Its 25th Anniversary	49
Stromal KITL/SCF Maintains Pancreas Tissue Homeostasis and Restrains Tumor Progression	48
Spatial Mapping of the Precancer-to-Cancer Transition in Breast and Prostate	48
Illuminating a Dark Kinase in the Mesenchymal Cancer Cell State	48
Bone-Induced HER2 Promotes Secondary Metastasis in HR+/HER2− Breast Cancer	48
The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade	47

Combining TIGIT Blockade with MDSC Inhibition Hinders Breast Cancer Bone Metastasis by Activating Antitumor Immunity	46
SUV39H1 Ablation Enhances Long-term CAR T Function in Solid Tumors	46
Which Small Molecule? Selecting Chemical Probes for Use in Cancer Research and Target Validation	46
A High-Fiber, Plant-Based Diet in Myeloma Precursor Disorders: Results from the NUTRIVENTION Clinical Trial and Preclinical Vk*MYC Model	46
Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas	45
Quantifying the Expanding Landscape of Clinical Actionability for Patients with Cancer	45
Cancer-Associated Fibroblasts Serve as Decoys to Suppress NK Cell Anticancer Cytotoxicity in Breast Cancer	44
Homing In on RNA Fusions in Breast Cancer	43
ImmunoGen Takeover Caps Year of Record ADC Investments	43
Specific Anatomic Transcriptomes Drive Oncogenesis in Melanoma	43
A Whole Cancer Cell–Based Vaccine Boosts Cell Killing and Antitumor Immunity	43
Antitumor Plasma Cells Mature Within Tertiary Lymphoid Structures	43
Structure of SHOC2–PP1C–RAS Reveals a Mechanism of RAF Activation	43
Tumor Microenvironment Immune Changes Support Anti-CD19 CAR T-cell Efficacy	42
Kidney Cancer Researcher Tapped as NCI Director	42
Molecular Profiles Distinguish Brain Metastases of Diverse Neural Impact	42
Insights and Opportunity Costs in Applying Spatial Biology to Study the Tumor Microenvironment	41
Culture Media Tweak Makes Heartier CARs	41
Acknowledgment to Reviewers	41
Clonal GCB Cells Support Angioimmunoblastic T-cell Lymphoma Tumorigenesis	41
Lymphocyte Interaction Networks Drive Lung Cancer Immunosurveillance	41
An Atlas of Tumor Metabolism Uncovers Gene–Metabolite Interactions	41
HER2 Expression Impacts Trastuzumab Deruxtecan Efficacy in Breast Cancer	41
Highlighted Research Articles	40
Radical Collaboration: Reimagining Cancer Team Science	40
TNF Receptors Choose HSC Fate in Supporting Dnmt3a -Mutant Clonal Hematopoiesis	40
Targeting Acute Myeloid Leukemia Stem Cells through Perturbation of Mitochondrial Calcium	39
Condensate-Promoting ENL Mutation Drives Tumorigenesis In Vivo Through Dynamic Regulation of Histone Modifications and Gene Expression	39
Single-cell spatial atlas of high-grade serous ovarian cancer uncovers MHC class II as a key predictor of spatial tumor ecosystems and clinical outcomes	39
Toward AI-Powered Cancer Etiology Research	39
Biomolecular Condensation: A New Phase in Cancer Research	39
DNAJB1-PRKACA Fusion Drives Fibrolamellar Liver Cancer through Impaired SIK Signaling and CRTC2/p300-Mediated Transcriptional Reprogramming	38
Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma	38
Loss of p53 Induces Tolerance to Viral Mimicry as a Mechanism of Immune Evasion in Early Tumorigenesis	38
IFNα Potentiates Immune-Checkpoint Blockade by Rewiring Metabolic Cross-talk	37
So Grateful for My X: Sex Chromosomes Drive Differences in Glioblastoma Immunity	37
Pushing the Boundaries of Liquid Biopsies for Early Precision Intervention	37
Senescent Cancer Cells Are Vulnerable to Extrinsic Apoptosis Pathway Activation	36
MHC-I Cross-Dressing Supports Antitumor CD8+ T-cell Priming	36
On-Target BTK Mutations Promote Resistance to Noncovalent BTK Inhibitors	36
Single-Cell Tumor–Normal Analysis Proposes Combinatorial CAR Strategies	36
Artificial Intelligence and Machine Learning Technologies in Cancer Care: Addressing Disparities, Bias, and Data Diversity	36
Noted	36
Spectrum of Response to Platinum and PARP Inhibitors in Germline BRCA –Associated Pancreatic Cancer in the Clinical and Preclinical Setting	36
Driver Events of Gastric Cancer Differ According to Subtype and Ancestry	35
BTK Inhibitor Options Expand for CLL/SLL	35
In This Issue	35
Altered tRNA Isoacceptor Abundance Regulates Breast Cancer Metastasis	35
High-Endothelial Venules Promote Permissive T-cell Niches after Immunotherapy	35
Disruption of KAT8–IRF1 Condensate Formation Reduces PD-L1 Expression	34
Gut Microbiota Regulate PD-L2 Expression and Immunotherapy Response	34
Nociceptor Neurons Affect Immunosurveillance and Tumor Growth	34
PHGDH Inhibition Overcomes Glioblastoma Resistance to T-cell Therapy	34
Primary, Metastatic Tumors Vary Genomically by Cancer Type	33
Artificial Intelligence Identifies Novel Disease Pathways	33
Dangerous Liaisons between Tet2 Mutation, Inflammatory Monocytes, and Leukemogenesis	33
Intrinsically Disordered Regions Control cBAF Condensation and Interactions	33
Correction: Creating MHC-Restricted Neoantigens with Covalent Inhibitors That Can Be Targeted by Immune Therapy	33
HPV42, a “Low-Risk” Type, and Digital Papillary Adenocarcinoma	33
Correction: Animal Alternatives OK'd by New Law	33
Y Chromosome Loss Drives Bladder Cancer Aggressiveness and Immune Evasion	32
Germline–Somatic Liaison Dictates Cancer Subtypes via de novo Steroid Biosynthesis	32
Correction: Highlights of FDA Oncology Approvals in 2023: Bispecific T-cell Engagers, Pediatric Indications, and Inclusive Drug Development	32
Personalized mRNA Vaccine Spurs Lasting Immunity in TNBC	31
Glucocorticoid Receptor Antagonist Approved for Ovarian Cancer	31
Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer	30
Senescence Defines a Distinct Subset of Myofibroblasts That Orchestrates Immunosuppression in Pancreatic Cancer	30
LINE-1 Locus Transcription Nucleates Oncogenic Chromatin Architecture	30
Immunogenicity and Efficacy of Personalized Adjuvant mRNA Cancer Vaccines	30
Tackling Cancer through Global Team Science	29
A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas	29
Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants	29
Receptor-interacting Protein Kinase 2 Is an Immunotherapy Target in Pancreatic Cancer	29
Cell States in Cancer: Drivers, Passengers, and Trailers	28
The SCRUM-MONSTAR Cancer-Omics Ecosystem: Striving for a Quantum Leap in Precision Medicine	28
Mitochondrial Glutathione Import Enables Breast Cancer Metastasis via Integrated Stress Response Signaling	28
Targeting Exposed Phosphatidylserine Boosts Antigen-Specific T-Cell Response	28
Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection	28
The Origin of Highly Elevated Cell-Free DNA in Healthy Individuals and Patients with Pancreatic, Colorectal, Lung, or Ovarian Cancer	28
Noninvasive Detection of Neuroendocrine Prostate Cancer through Targeted Cell-free DNA Methylation	28
Micronuclei and Cancer	27
Intratumoral Niches Control CD8+ T-cell Differentiation following ICB	27
Leading Oral SERD Shows Prolonged Activity	27
GPRC5D CAR T Cells Are Active in BCMA CAR T–Refractory Multiple Myeloma	27
Noted	27
MonumenTAL Results for Talquetamab in Myeloma	26
A Trifunctional Natural Killer Cell Engager Can Target CD123+ Leukemia	26
Clinically Actionable Alterations Are Associated with African Ancestry	26
FOXA2 Promotes Prostate Cancer Lineage Plasticity through KIT	26
A Pan-KRAS Inhibitor Impedes Common KRAS Oncoproteins and Tumor Growth	26
Noted	26
Chromosomal Instability Induces Non–Cell-Autonomous Cancer Progression	25
Early Clones Expand in Richter Transformation of Chronic Lymphocytic Leukemia	25
ZBP1 Mediates Replicative Crisis through Telomere-to-Mitochondria Signaling	25
Cold Exposure Suppresses Tumor Growth through BAT Activation	25