Cancer Discovery

Article	Citations
AI-Supported Mammography “Safe,” Cuts Workload	6276
HLA-E:CD94–NKG2A Mediates Circulating Tumor Cell Immune Evasion	657
Mutation-Driven Alveolar Cell Reprogramming Dictates Lung Cancer Progression	338
Succinyl-CoA and Cobalamin Are Biomarkers That Improve Anal Cancer Screening	299
Human Tumor Cells Display an Oncogene-like Addiction to Aneuploidy	242
Q&A: Philip Greenberg on T Cells, IO's Future	240
Structure of the Tumor Stroma Predicts Invasive Breast Cancer Relapse	220
Shattered Chromosomes Undergo Mitotic Tethering during Chromothripsis	219
PARADIGM Identifies Associations between Drugs, the Microbiome, and Mortality	204
Air Pollution Promotes Oncogenic Expansion of Mutant Lung Progenitor Cells	201
Transposable Element Signatures Define Stages of T-cell Exhaustion	198
Probing Clonal Hematopoiesis in Liquid Biopsy	191
Collagen Receptor Implicated in Immune Exclusion	188
IL7 Genetic Variation Predicts Immune-Related Adverse Events	188
Low-Glycemic Diets Restrict Tumor Growth through Altered Lipid Metabolism	188
Drafting a Blueprint for European Cancer Research	185
Dendritic Cell Circadian Rhythm Governs the Antitumor Immune Response	179
Mouse Models Provide Insight into Factors Affecting BiTE Efficacy	170
Highlighted research articles	168
REFLECTions on Combination Therapies Empowered by Data Sharing	163
Proteostasis Network Modulation Promotes Resistance to KRAS Inhibitors	163
Highlighted research articles	157
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission	146
Convergence of Targeted and Immune Therapies for the Treatment of Oncogene-Driven Cancers	143
Adjuvant PD-1 Blockade in Resected Melanoma: Is Preventing Recurrence Enough?	140

PIN1 Prolyl Isomerase Promotes Initiation and Progression of Bladder Cancer through the SREBP2-Mediated Cholesterol Biosynthesis Pathway	139
Correction: Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer	139
Selpercatinib Shifts Treatment Paradigm for MTC and NSCLC	138
Cytosolic Phospholipase A2 Determines Intercellular Heterogeneity of Stress Granules and Chemotherapy Response	134
Exome Sequencing IDs Hidden Disease Variants	133
Intrinsic Properties of the Lymph Node Render It Immunologically Susceptible to Metastasis	132
GIST: Molecular Profiling Suggests 2nd Therapy	128
Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta	128
A Guide to Extrachromosomal DNA: Cancer’s Dynamic Circular Genome	126
The 3D Revolution in Cancer Discovery	126
Combination Diagnostics: Adding Blood-Based ctDNA Screening to Low-Dose CT Imaging for Early Detection of Lung Cancer	123
Rational Protein Engineering to Enhance MHC-Independent T-cell Receptors	123
Trispecifics Improve Immune-Cell Engagement	122
Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma	122
An NK-cell Therapy for CD30+ Lymphomas	121
Gut microbiota modulation through Akkermansia spp. supplementation increases CAR-T cell potency	121
RAS Drives Malignancy through Altered Stem Cell/Microenvironment Cross-talk	119
p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression	119
A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy	118
INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors	116
Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma	114
CHD2 Regulates Neuron–Glioma Interactions in Pediatric Glioma	112
Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression	111
Lymph Node Metastasis Induces Immune Tolerance and Distant Metastasis	109
Presurgery Plus Postsurgery Immunotherapy Ups Survival in NSCLC	108
Multicellular Spatial Organization Determines Immunotherapy Response	105
Chronic Inflammation Drives TP53-Mutant Leukemic Evolution	105
Response to Low Antigen Density Is Improved by HLA-Independent T-cell Receptors	101
In This Issue	101
Amgen Deal Nets Potential Cancer Therapies	101
Tumor-Derived Extracellular Vesicles and Particles Inhibit Liver Function	100
The Proteasome Regulator PSME4 Modulates Antitumor Immunity	100
Intestinal Microbiome Inhibits CD8+ T Cells via the Calcineurin–NFAT Axis	100
FMRP Depletion Reprograms an Immunosuppressive Microenvironment	99
New Strategy May Thwart Glioblastoma Resistance	99
TILs Outperform Ipilimumab in Melanoma	98
Hyperactivation of Oncogenic Pathways Hinders Cancer Cell Survival	97
Lymph Node–Specific IFNγ Levels Affect CD8+ T-cell Priming against Tumors	95
Revumenib Is Safe and Efficacious, but MEN1 Mutations Mediate Resistance	93
What's Next for Sotorasib in NSCLC?	92
Aged Lungs Enable Metastatic Outgrowth of Dormant Melanoma Cells	91
Biomarker Testing Falls Short in NSCLC	88
In This Issue	86
Cancer in the Prime of Life: Etiologic Insights and Supportive Oncologic Interventions for the Rising Burden of Young Adult Cancer	84
Moving Spatially Resolved Multiplexed Protein Profiling toward Clinical Oncology	84
Noninvasive and Multicancer Biomarkers: The Promise of LINE-1 Retrotransposons	84
Bridging the Gap between Diseases of the Stomach and Lower Esophagus	84
New Immunotherapy Combinations Enter the Battlefield of Malignant Mesothelioma	83
Harnessing Mitochondrial Mutations to ATAC Clonal Evolution in CLL	83
Akk Abundance Alters Survival in Patients with NSCLC on ICIs	82

Temozolomide Treatment Alters Mismatch Repair and Boosts Mutational Burden in Tumor and Blood of Colorectal Cancer Patients	82
Beneath the Surface: Neoantigens beyond Chromosomal DNA Mutations	82
AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer	80
Atypical Small Cell Lung Cancer: A New Malignancy Characterized by Chromothripsis, Carcinoid Tumors, and Wild-type RB1 and TP53	79
Rlf–Mycl Gene Fusion Drives Tumorigenesis and Metastasis in a Mouse Model of Small Cell Lung Cancer	79
Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy	79
Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth	78
Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer	77
Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity	77
A Molecular Voyage: Multiomics Insights into Circulating Tumor Cells	77
NRF2: KEAPing Tumors Protected	77
A Transitional Cell Population Is Enriched in Aggressive Human Medulloblastoma	77
Study Sniffs Out New Glioma Mechanism	76
A Spatiotemporal Positive Feedback Loop Exists Between TAMs and CD8+ T Cells	76
ABBV-383 Demonstrates Tolerability and Efficacy in Relapsed/Refractory MM	76
Chromatin Remodeling Factors Drive Epigenetic Changes Crucial for T-cell Exhaustion	76
Distinct Clonal Patterns Exist between Benign and Malignant Tissue	75
IL6 Blockade Reduces Immunotherapy-Induced Immune-Related Adverse Events	74
Lasker Honors Discovery of Cell Adhesion Molecules	73
Single-Cell Lineage Tracing of Metastasis Uncovers an EMT Continuum	72
Ibrutinib with R-CHOP Differentially Affects Genetic Subtypes of DLBCL	71
Resistant KRAS(G12C) Inhibitor Subclones Exhibit Heterogeneous Alterations	71
Blinatumomab Nonresponse Is Associated with Poor CD19-CAR Outcome in B-ALL	70
The Kinase Module of the Mediator Complex Inhibits CAR T-cell Function	69
MCED Testing Enters New Diagnostic Realms	67
Phosphocreatine Promotes Epigenetic Reprogramming to Facilitate Glioblastoma Growth Through Stabilizing BRD2	66
High-Purity CTC RNA Sequencing Identifies Prostate Cancer Lineage Phenotypes Prognostic for Clinical Outcomes	66
MEDI5752 Suppresses Two Immune Checkpoints	65
Heritable Defects in Mitotic and Telomere Function Confer Sarcoma Risk	65
The Hallmarks of Predictive Oncology	65
Prenatal Chemotherapy and Its Impact on the Genome of Fetal Hematopoiesis	65
Cancer Cells Adapt to SWI/SNF Inhibition through Compensatory EP400 Function	65
Q&A: Robert Vonderheide on Immunotherapy Advances	65
Air Pollution–Lung Cancer Link Identified	65
Sex Hormone Signaling Suppresses Ferroptosis via Phospholipid Remodeling	64
Advancing Global Health Equity in Oncology Clinical Trial Access	64
CD8-Targeted IL2 Unleashes Tumor-Specific Immunity in Human Cancer Tissue by Reviving the Dysfunctional T-cell Pool	64
D3S-001, a KRAS G12C Inhibitor with Rapid Target Engagement Kinetics, Overcomes Nucleotide Cycling, and Demonstrates Robust Preclinical and Clinical Activities	63
Cancer Neuroscience of Brain Tumors: From Multicellular Networks to Neuroscience-Instructed Cancer Therapies	63
Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML	63
Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia	62
STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts	62
Single-Cell Sequencing Reveals Trajectory of Tumor-Infiltrating Lymphocyte States in Pancreatic Cancer	62
Integrative Analysis of a Large Real-World Cohort of Small Cell Lung Cancer Identifies Distinct Genetic Subtypes and Insights into Histologic Transformation	62
EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma	62
MDM2-PROTAC versus MDM2 Inhibitors: Beyond p53 Reactivation	62
Acquired Cross-Resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC Paralogs	61
Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors	61
MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer	60
Human Colon Cancer–Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice	60
CD19/CD20 Bispecific Chimeric Antigen Receptor (CAR) in Naive/Memory T Cells for the Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma	60
Carcinogenic Human Metabolites Are Revealed Using “Metabokiller”	59
Astronomical Imaging Can Be Used to Analyze Response to Immunotherapy	59
Distinct Treatment-Related Immunologic Biomarkers Are Identified in PDAC	59
Structure of the Ligand-Bound HER2–HER3 Dimer Reveals a Dynamic Interface	59
Glioma Infiltration and Progression Are Driven by Remote Neuronal Activation	59
Surface Expression of NRP1 on Tregs Affects Outcome in Patients with Cancer	59
Silent Mutations Reveal a Novel Treatment for RASQ61 Cancers	55
The Evolutionary History of Breast Cancer and Related Clones Is Revealed	54
VCAM1 Mediates Innate Immune Tolerance of Hematopoietic and Leukemic Stem Cells	54
A Deep Learning Model for Cancer Type Prediction Sets a New Standard	54
IL4 Signaling in the Bone Marrow Promotes Protumorigenic Myelopoiesis	54
The CDK4/6 Inhibitor Ribociclib Leads to Stable Disease in Pediatric Cancers	54
ESCRT Protein Inhibition Enhances CTL-Mediated Cytolysis of Tumor Cells	54
Gut Microbiota May Mediate AEs	54
Court Rulings Complicate Decisions for Pregnant Patients	54
Antitrust Order Aimed at Equalizing MCED Field	53
Heterologous Cancer Vaccines plus Checkpoint Inhibitors Show Therapeutic Benefit	53
Highlighted Research Articles	52
Glucose Metabolism in TAMs Promotes Metastasis and Drug Resistance	52
Peto’s Paradox Is Dead. Long Live Peto’s Paradox	52
The APOE–TREM2 Axis Mediates Senescent Neutrophils in Prostate Cancer	52
Epitope Editing Prevents Off-Tumor Toxicity of CAR T-cell Therapy in AML	52
Gene-Specific Machine Learning Models to Classify Driver Mutations in Clonal Hematopoiesis	51
Illuminating a Dark Kinase in the Mesenchymal Cancer Cell State	51
If You Build It, Patients with Rare Cancers Will Come: A Successful Clinical Trial in Relapsed and Refractory JMML	51
Methylation Is Best for cfDNA Multicancer Early Detection Tests	50
Catalytic inhibition of KAT6/KAT7 enhances the efficacy and overcomes primary and acquired resistance to Menin inhibitors in MLL leukaemia	50
SUV39H1 Ablation Enhances Long-term CAR T Function in Solid Tumors	50
Sotorasib Tackles KRASG12C-Mutated Pancreatic Cancer	50

Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas	50
HeLa Cases Prompt More Thinking on Ethics	50
Tissue-Agnostic Drug Development: A New Path to Drug Approval	49
Bone-Induced HER2 Promotes Secondary Metastasis in HR+/HER2− Breast Cancer	49
When Cancer Cells Become the Enablers of an Antitumor Immune Response	49
Six-Month Efficacy and Toxicity Profile of BNT162b2 Vaccine in Cancer Patients with Solid Tumors	49
Stromal KITL/SCF Maintains Pancreas Tissue Homeostasis and Restrains Tumor Progression	48
Which Small Molecule? Selecting Chemical Probes for Use in Cancer Research and Target Validation	48
The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade	47
Tracing Founder Mutations in Circulating and Tissue-Resident Follicular Lymphoma Precursors	47
DietaryLactobacillus-Derived Exopolysaccharide Enhances Immune-Checkpoint Blockade Therapy	46
Cancer-Associated Fibroblasts Serve as Decoys to Suppress NK Cell Anticancer Cytotoxicity in Breast Cancer	46
Combining TIGIT Blockade with MDSC Inhibition Hinders Breast Cancer Bone Metastasis by Activating Antitumor Immunity	46
CD137 (4-1BB)-Based Cancer Immunotherapy on Its 25th Anniversary	46
Bacterial Genotoxin Accelerates Transient Infection–Driven Murine Colon Tumorigenesis	46
Ribosome ADP-Ribosylation Controls Protein Synthesis in Ovarian Cancer	45
Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence	45
A Bacterial-Based Immunotherapy for PDAC	45
Molecular Profiles Distinguish Brain Metastases of Diverse Neural Impact	45
Quantifying the Expanding Landscape of Clinical Actionability for Patients with Cancer	45
A Whole Cancer Cell–Based Vaccine Boosts Cell Killing and Antitumor Immunity	45
Specific Anatomic Transcriptomes Drive Oncogenesis in Melanoma	45
Combined Inhibition of SHP2 and CXCR1/2 Promotes Antitumor T-cell Response in NSCLC	45
Tumor-Reactive Antibodies Emerge from Nonbinding and Autoreactive Precursors	44
ImmunoGen Takeover Caps Year of Record ADC Investments	44
Antitumor Plasma Cells Mature Within Tertiary Lymphoid Structures	44
Atypical EGFR Mutations Show Heterogeneity	43
Structure of SHOC2–PP1C–RAS Reveals a Mechanism of RAF Activation	43
Distinct Mutational Processes Influence Germline DNA Mutations	43
Homing In on RNA Fusions in Breast Cancer	43
Culture Media Tweak Makes Heartier CARs	43
TIM3 Blockade in Dendritic Cells May Potentiate Antitumor Immunity	43
Acknowledgment to Reviewers	42
The Bispecific Antibody Epcoritamab Produces Responses in Lymphoma	42
A Base Editing Platform Shows Function of Cancer-Associated Variants	42
Acknowledgment to Reviewers	42
Kidney Cancer Researcher Tapped as NCI Director	42
An Atlas of Tumor Metabolism Uncovers Gene–Metabolite Interactions	41
HER2 Expression Impacts Trastuzumab Deruxtecan Efficacy in Breast Cancer	41
Lymphocyte Interaction Networks Drive Lung Cancer Immunosurveillance	41
In This Issue	41
COVID-19 Vaccines Complicate Mammograms	41
Tumor Microenvironment Immune Changes Support Anti-CD19 CAR T-cell Efficacy	41
Cancer-Causative Mutations Occurring in Early Embryogenesis	40
Precision Cancer Medicine: Large Studies Indicate Steady Progress	40
TNF Receptors Choose HSC Fate in SupportingDnmt3a-Mutant Clonal Hematopoiesis	38
Correction: High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability	38
Insights and Opportunity Costs in Applying Spatial Biology to Study the Tumor Microenvironment	38
ATM Inhibition Sensitizes ALT Neuroblastomas to Chemotherapy	37
DNAJB1-PRKACA Fusion Drives Fibrolamellar Liver Cancer through Impaired SIK Signaling and CRTC2/p300-Mediated Transcriptional Reprogramming	37
Artificial Intelligence and Machine Learning Technologies in Cancer Care: Addressing Disparities, Bias, and Data Diversity	37
Loss of p53 Induces Tolerance to Viral Mimicry as a Mechanism of Immune Evasion in Early Tumorigenesis	36
So Grateful for My X: Sex Chromosomes Drive Differences in Glioblastoma Immunity	35
Clonal GCB Cells Support Angioimmunoblastic T-cell Lymphoma Tumorigenesis	35
Targeting Acute Myeloid Leukemia Stem Cells through Perturbation of Mitochondrial Calcium	34
Highlighted Research Articles	34
IFNα Potentiates Immune-Checkpoint Blockade by Rewiring Metabolic Cross-talk	34
Pushing the Boundaries of Liquid Biopsies for Early Precision Intervention	34
Condensate-Promoting ENL Mutation Drives Tumorigenesis In Vivo Through Dynamic Regulation of Histone Modifications and Gene Expression	33
Spectrum of Response to Platinum and PARP Inhibitors in Germline BRCA–Associated Pancreatic Cancer in the Clinical and Preclinical Setting	33
Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma	32
Single-Cell Tumor–Normal Analysis Proposes Combinatorial CAR Strategies	32
Radical Collaboration: Reimagining Cancer Team Science	32
Single-Cell Atlas of Lineage States, Tumor Microenvironment, and Subtype-Specific Expression Programs in Gastric Cancer	32
Machine Learning Models ID Cancer Drivers	32
Biomolecular Condensation: A New Phase in Cancer Research	32
In This Issue	32
RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy	32
Altered tRNA Isoacceptor Abundance Regulates Breast Cancer Metastasis	31
Noted	31
Y Chromosome Loss Drives Bladder Cancer Aggressiveness and Immune Evasion	31
Dual Immunotherapy Makes Strides against HCC	31
In This Issue	31
On-Target BTK Mutations Promote Resistance to Noncovalent BTK Inhibitors	30
A High-Fat Diet Controls MHC Class II on ISCs via the Microbiome	30
Approved Drugs May Reduce Anthracycline Drug–Related Cardiotoxicity	30
Ibrutinib Treatment in Early Stage CLL Prolongs Time to Active Disease	30
Colonic Microbiota Promote Antitumor Immunity in Colorectal Cancer	30
Q&A: Ted Laetsch on Tumor-Agnostic Therapies	30
HSCT Chemotherapy Supports Peripheral Macrophage Engraftment of the Brain	30
Moonshot Redux to Focus on Prevention, Screening	30
MHC-I Cross-Dressing Supports Antitumor CD8+ T-cell Priming	30
Correction: Highlights of FDA Oncology Approvals in 2023: Bispecific T-cell Engagers, Pediatric Indications, and Inclusive Drug Development	29
Senescent Cancer Cells Are Vulnerable to Extrinsic Apoptosis Pathway Activation	29
Nociceptor Neurons Affect Immunosurveillance and Tumor Growth	29
High-Endothelial Venules Promote Permissive T-cell Niches after Immunotherapy	29
Correction: Creating MHC-Restricted Neoantigens with Covalent Inhibitors That Can Be Targeted by Immune Therapy	29
BTK Inhibitor Options Expand for CLL/SLL	29
Intrinsically Disordered Regions Control cBAF Condensation and Interactions	27
Gut Microbiota Regulate PD-L2 Expression and Immunotherapy Response	27
Driver Events of Gastric Cancer Differ According to Subtype and Ancestry	27
Disruption of KAT8–IRF1 Condensate Formation Reduces PD-L1 Expression	27
PHGDH Inhibition Overcomes Glioblastoma Resistance to T-cell Therapy	27
Primary, Metastatic Tumors Vary Genomically by Cancer Type	27
Artificial Intelligence Identifies Novel Disease Pathways	26