Cancer Discovery

Article	Citations
Drafting a Blueprint for European Cancer Research	6876
Highlighted research articles	729
Low-Glycemic Diets Restrict Tumor Growth through Altered Lipid Metabolism	371
Mouse Models Provide Insight into Factors Affecting BiTE Efficacy	267
Q&A: Philip Greenberg on T Cells, IO's Future	257
HLA-E:CD94–NKG2A Mediates Circulating Tumor Cell Immune Evasion	240
AI-Supported Mammography “Safe,” Cuts Workload	237
Mutation-Driven Alveolar Cell Reprogramming Dictates Lung Cancer Progression	235
Succinyl-CoA and Cobalamin Are Biomarkers That Improve Anal Cancer Screening	223
Human Tumor Cells Display an Oncogene-like Addiction to Aneuploidy	218
Probing Clonal Hematopoiesis in Liquid Biopsy	216
Shattered Chromosomes Undergo Mitotic Tethering during Chromothripsis	214
PARADIGM Identifies Associations between Drugs, the Microbiome, and Mortality	199
Air Pollution Promotes Oncogenic Expansion of Mutant Lung Progenitor Cells	179
Selpercatinib Shifts Treatment Paradigm for MTC and NSCLC	179
Correction: Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer	172
REFLECTions on Combination Therapies Empowered by Data Sharing	167
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission	164
Highlighted research articles	159
Proteostasis Network Modulation Promotes Resistance to KRAS Inhibitors	156
Adjuvant PD-1 Blockade in Resected Melanoma: Is Preventing Recurrence Enough?	144
Structure of the Tumor Stroma Predicts Invasive Breast Cancer Relapse	141
Dendritic Cell Circadian Rhythm Governs the Antitumor Immune Response	139
Convergence of Targeted and Immune Therapies for the Treatment of Oncogene-Driven Cancers	136
p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression	134

Cytosolic Phospholipase A2 Determines Intercellular Heterogeneity of Stress Granules and Chemotherapy Response	134
Transposable Element Signatures Define Stages of T-cell Exhaustion	133
IL7 Genetic Variation Predicts Immune-Related Adverse Events	133
Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta	131
Combination Diagnostics: Adding Blood-Based ctDNA Screening to Low-Dose CT Imaging for Early Detection of Lung Cancer	131
Trispecifics Improve Immune-Cell Engagement	131
Intrinsic Properties of the Lymph Node Render It Immunologically Susceptible to Metastasis	130
Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma	129
RAS Drives Malignancy through Altered Stem Cell/Microenvironment Cross-talk	129
GIST: Molecular Profiling Suggests 2nd Therapy	128
Exome Sequencing IDs Hidden Disease Variants	127
Rational Protein Engineering to Enhance MHC-Independent T-cell Receptors	126
Collagen Receptor Implicated in Immune Exclusion	124
Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression	123
An NK-cell Therapy for CD30+ Lymphomas	123
PIN1 Prolyl Isomerase Promotes Initiation and Progression of Bladder Cancer through the SREBP2-Mediated Cholesterol Biosynthesis Pathway	120
The 3D Revolution in Cancer Discovery	118
A Guide to Extrachromosomal DNA: Cancer’s Dynamic Circular Genome	116
Gut Microbiota Modulation through Akkermansia spp. Supplementation Increases CAR T-cell Potency	115
CHD2 Regulates Neuron–Glioma Interactions in Pediatric Glioma	113
Lymph Node Metastasis Induces Immune Tolerance and Distant Metastasis	113
Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma	112
The Dark Side of NK Cells in Cancer Immunotherapy	111
Presurgery Plus Postsurgery Immunotherapy Ups Survival in NSCLC	109
A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy	109
New Strategy May Thwart Glioblastoma Resistance	109
FMRP Depletion Reprograms an Immunosuppressive Microenvironment	107
Tumor-Derived Extracellular Vesicles and Particles Inhibit Liver Function	105
The Proteasome Regulator PSME4 Modulates Antitumor Immunity	105
Chronic Inflammation Drives TP53-Mutant Leukemic Evolution	103
In This Issue	99
Multicellular Spatial Organization Determines Immunotherapy Response	99
Revumenib Is Safe and Efficacious, but MEN1 Mutations Mediate Resistance	96
Response to Low Antigen Density Is Improved by HLA-Independent T-cell Receptors	96
What's Next for Sotorasib in NSCLC?	95
Aged Lungs Enable Metastatic Outgrowth of Dormant Melanoma Cells	95
Bridging the Gap between Diseases of the Stomach and Lower Esophagus	94
Noninvasive and Multicancer Biomarkers: The Promise of LINE-1 Retrotransposons	94
Beneath the Surface: Neoantigens beyond Chromosomal DNA Mutations	93
A Molecular Voyage: Multiomics Insights into Circulating Tumor Cells	92
Harnessing Mitochondrial Mutations to ATAC Clonal Evolution in CLL	92
Akk Abundance Alters Survival in Patients with NSCLC on ICIs	91
In This Issue	89
Cancer in the Prime of Life: Etiologic Insights and Supportive Oncologic Interventions for the Rising Burden of Young Adult Cancer	89
TILs Outperform Ipilimumab in Melanoma	88
Hyperactivation of Oncogenic Pathways Hinders Cancer Cell Survival	87
Lymph Node–Specific IFNγ Levels Affect CD8+ T-cell Priming against Tumors	86
Atypical Small Cell Lung Cancer: A New Malignancy Characterized by Chromothripsis, Carcinoid Tumors, and Wild-type RB1 and TP53	85
Moving Spatially Resolved Multiplexed Protein Profiling toward Clinical Oncology	85
Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity	85

Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer	85
Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy	84
New Immunotherapy Combinations Enter the Battlefield of Malignant Mesothelioma	84
Intestinal Microbiome Inhibits CD8+ T Cells via the Calcineurin–NFAT Axis	83
Rlf–Mycl Gene Fusion Drives Tumorigenesis and Metastasis in a Mouse Model of Small Cell Lung Cancer	83
Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Protumorigenic T-cell Polarization	83
Temozolomide Treatment Alters Mismatch Repair and Boosts Mutational Burden in Tumor and Blood of Colorectal Cancer Patients	83
AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer	81
NRF2: KEAPing Tumors Protected	80
Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth	80
The Kinase Module of the Mediator Complex Inhibits CAR T-cell Function	79
MCED Testing Enters New Diagnostic Realms	78
Resistant KRAS(G12C) Inhibitor Subclones Exhibit Heterogeneous Alterations	77
A Spatiotemporal Positive Feedback Loop Exists Between TAMs and CD8+ T Cells	75
Blinatumomab Nonresponse Is Associated with Poor CD19-CAR Outcome in B-ALL	75
Chromatin Remodeling Factors Drive Epigenetic Changes Crucial for T-cell Exhaustion	75
Ibrutinib with R-CHOP Differentially Affects Genetic Subtypes of DLBCL	75
Distinct Clonal Patterns Exist between Benign and Malignant Tissue	75
Study Sniffs Out New Glioma Mechanism	75
IL6 Blockade Reduces Immunotherapy-Induced Immune-Related Adverse Events	74
Lasker Honors Discovery of Cell Adhesion Molecules	74
Prenatal Chemotherapy and Its Impact on the Genome of Fetal Hematopoiesis	73
ABBV-383 Demonstrates Tolerability and Efficacy in Relapsed/Refractory MM	73
Heritable Defects in Mitotic and Telomere Function Confer Sarcoma Risk	72
A Transitional Cell Population Is Enriched in Aggressive Human Medulloblastoma	72
Q&A: Robert Vonderheide on Immunotherapy Advances	72
Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML	71
Cancer Neuroscience of Brain Tumors: From Multicellular Networks to Neuroscience-Instructed Cancer Therapies	71
Phosphocreatine Promotes Epigenetic Reprogramming to Facilitate Glioblastoma Growth Through Stabilizing BRD2	70
Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors	70
CD8-Targeted IL2 Unleashes Tumor-Specific Immunity in Human Cancer Tissue by Reviving the Dysfunctional T-cell Pool	70
STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts	70
Epigenetic regulation of chromosomal instability by EZH2 methyltransferase.	69
Air Pollution–Lung Cancer Link Identified	69
Advancing Global Health Equity in Oncology Clinical Trial Access	69
MEDI5752 Suppresses Two Immune Checkpoints	69
Cancer Cells Adapt to SWI/SNF Inhibition through Compensatory EP400 Function	69
Sex Hormone Signaling Suppresses Ferroptosis via Phospholipid Remodeling	68
High-Purity CTC RNA Sequencing Identifies Prostate Cancer Lineage Phenotypes Prognostic for Clinical Outcomes	68
MDM2-PROTAC versus MDM2 Inhibitors: Beyond p53 Reactivation	68
A plastic EMP1⁺ to LGR5⁺ cell state conversion as a bypass to KRAS-G12D pharmacological inhibition in metastatic colorectal cancer	68
Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia	67
MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer	66
Human Colon Cancer–Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice	63
Single-Cell Sequencing Reveals Trajectory of Tumor-Infiltrating Lymphocyte States in Pancreatic Cancer	63
Integrative Analysis of a Large Real-World Cohort of Small Cell Lung Cancer Identifies Distinct Genetic Subtypes and Insights into Histologic Transformation	63
Acquired Cross-Resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC Paralogs	63
CD19/CD20 Bispecific Chimeric Antigen Receptor (CAR) in Naive/Memory T Cells for the Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma	62
D3S-001, a KRAS G12C Inhibitor with Rapid Target Engagement Kinetics, Overcomes Nucleotide Cycling, and Demonstrates Robust Preclinical and Clinical Activities	62
EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma	62
The Hallmarks of Predictive Oncology	62
Surface Expression of NRP1 on Tregs Affects Outcome in Patients with Cancer	61
Glioma Infiltration and Progression Are Driven by Remote Neuronal Activation	61
Structure of the Ligand-Bound HER2–HER3 Dimer Reveals a Dynamic Interface	61
Silent Mutations Reveal a Novel Treatment for RASQ61 Cancers	61
ESCRT Protein Inhibition Enhances CTL-Mediated Cytolysis of Tumor Cells	60
Court Rulings Complicate Decisions for Pregnant Patients	60
IL4 Signaling in the Bone Marrow Promotes Protumorigenic Myelopoiesis	58
VCAM1 Mediates Innate Immune Tolerance of Hematopoietic and Leukemic Stem Cells	58
Carcinogenic Human Metabolites Are Revealed Using “Metabokiller”	58
Antitrust Order Aimed at Equalizing MCED Field	57
Distinct Treatment-Related Immunologic Biomarkers Are Identified in PDAC	57
The Evolutionary History of Breast Cancer and Related Clones Is Revealed	57
Glucose Metabolism in TAMs Promotes Metastasis and Drug Resistance	56
The APOE–TREM2 Axis Mediates Senescent Neutrophils in Prostate Cancer	56
Peto’s Paradox Is Dead. Long Live Peto’s Paradox	55
If You Build It, Patients with Rare Cancers Will Come: A Successful Clinical Trial in Relapsed and Refractory JMML	55
Highlighted Research Articles	55
Heterologous Cancer Vaccines plus Checkpoint Inhibitors Show Therapeutic Benefit	55
Stromal KITL/SCF Maintains Pancreas Tissue Homeostasis and Restrains Tumor Progression	54
Epitope Editing Prevents Off-Tumor Toxicity of CAR T-cell Therapy in AML	54
HeLa Cases Prompt More Thinking on Ethics	54
The molecular and functional landscape of resistance to FOLFIRI chemotherapy in metastatic colorectal cancer	54
Illuminating a Dark Kinase in the Mesenchymal Cancer Cell State	54
Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence	53
Methylation Is Best for cfDNA Multicancer Early Detection Tests	53
Which Small Molecule? Selecting Chemical Probes for Use in Cancer Research and Target Validation	53
Bone-Induced HER2 Promotes Secondary Metastasis in HR+/HER2− Breast Cancer	53
Gene-Specific Machine Learning Models to Classify Driver Mutations in Clonal Hematopoiesis	53
Combining TIGIT Blockade with MDSC Inhibition Hinders Breast Cancer Bone Metastasis by Activating Antitumor Immunity	52

Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas	52
Cancer-Associated Fibroblasts Serve as Decoys to Suppress NK Cell Anticancer Cytotoxicity in Breast Cancer	52
Sotorasib Tackles KRASG12C-Mutated Pancreatic Cancer	52
Tracing Founder Mutations in Circulating and Tissue-Resident Follicular Lymphoma Precursors	51
When Cancer Cells Become the Enablers of an Antitumor Immune Response	51
SUV39H1 Ablation Enhances Long-term CAR T Function in Solid Tumors	50
Bacterial Genotoxin Accelerates Transient Infection–Driven Murine Colon Tumorigenesis	50
The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade	49
A Deep Learning Model for Cancer Type Prediction Sets a New Standard	49
CD137 (4-1BB)-Based Cancer Immunotherapy on Its 25th Anniversary	49
Catalytic Inhibition of KAT6/KAT7 Enhances the Efficacy and Overcomes Primary and Acquired Resistance to Menin Inhibitors in MLL Leukemia	49
Quantifying the Expanding Landscape of Clinical Actionability for Patients with Cancer	48
DietaryLactobacillus-Derived Exopolysaccharide Enhances Immune-Checkpoint Blockade Therapy	48
A Whole Cancer Cell–Based Vaccine Boosts Cell Killing and Antitumor Immunity	47
Structure of SHOC2–PP1C–RAS Reveals a Mechanism of RAF Activation	47
ImmunoGen Takeover Caps Year of Record ADC Investments	47
A Bacterial-Based Immunotherapy for PDAC	47
Specific Anatomic Transcriptomes Drive Oncogenesis in Melanoma	46
Molecular Profiles Distinguish Brain Metastases of Diverse Neural Impact	44
Tumor-Reactive Antibodies Emerge from Nonbinding and Autoreactive Precursors	44
Homing In on RNA Fusions in Breast Cancer	44
Atypical EGFR Mutations Show Heterogeneity	44
Antitumor Plasma Cells Mature Within Tertiary Lymphoid Structures	44
Kidney Cancer Researcher Tapped as NCI Director	43
HER2 Expression Impacts Trastuzumab Deruxtecan Efficacy in Breast Cancer	42
Acknowledgment to Reviewers	42
Tumor Microenvironment Immune Changes Support Anti-CD19 CAR T-cell Efficacy	42
A Base Editing Platform Shows Function of Cancer-Associated Variants	42
In This Issue	41
Culture Media Tweak Makes Heartier CARs	41
Lymphocyte Interaction Networks Drive Lung Cancer Immunosurveillance	39
An Atlas of Tumor Metabolism Uncovers Gene–Metabolite Interactions	39
Acknowledgment to Reviewers	39
Precision Cancer Medicine: Large Studies Indicate Steady Progress	39
TNF Receptors Choose HSC Fate in SupportingDnmt3a-Mutant Clonal Hematopoiesis	38
The Bispecific Antibody Epcoritamab Produces Responses in Lymphoma	38
Condensate-Promoting ENL Mutation Drives Tumorigenesis In Vivo Through Dynamic Regulation of Histone Modifications and Gene Expression	38
Insights and Opportunity Costs in Applying Spatial Biology to Study the Tumor Microenvironment	38
IFNα Potentiates Immune-Checkpoint Blockade by Rewiring Metabolic Cross-talk	38
Highlighted Research Articles	37
Pushing the Boundaries of Liquid Biopsies for Early Precision Intervention	37
Radical Collaboration: Reimagining Cancer Team Science	37
DNAJB1-PRKACA Fusion Drives Fibrolamellar Liver Cancer through Impaired SIK Signaling and CRTC2/p300-Mediated Transcriptional Reprogramming	37
Loss of p53 Induces Tolerance to Viral Mimicry as a Mechanism of Immune Evasion in Early Tumorigenesis	37
So Grateful for My X: Sex Chromosomes Drive Differences in Glioblastoma Immunity	37
Biomolecular Condensation: A New Phase in Cancer Research	37
Clonal GCB Cells Support Angioimmunoblastic T-cell Lymphoma Tumorigenesis	36
Artificial Intelligence and Machine Learning Technologies in Cancer Care: Addressing Disparities, Bias, and Data Diversity	35
Cancer-Causative Mutations Occurring in Early Embryogenesis	35
Moonshot Redux to Focus on Prevention, Screening	35
Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma	35
Single-Cell Atlas of Lineage States, Tumor Microenvironment, and Subtype-Specific Expression Programs in Gastric Cancer	35
Colonic Microbiota Promote Antitumor Immunity in Colorectal Cancer	35
Single-Cell Tumor–Normal Analysis Proposes Combinatorial CAR Strategies	35
Targeting Acute Myeloid Leukemia Stem Cells through Perturbation of Mitochondrial Calcium	35
Spectrum of Response to Platinum and PARP Inhibitors in Germline BRCA–Associated Pancreatic Cancer in the Clinical and Preclinical Setting	35
Ibrutinib Treatment in Early Stage CLL Prolongs Time to Active Disease	35
Approved Drugs May Reduce Anthracycline Drug–Related Cardiotoxicity	34
MHC-I Cross-Dressing Supports Antitumor CD8+ T-cell Priming	34
Q&A: Ted Laetsch on Tumor-Agnostic Therapies	34
A High-Fat Diet Controls MHC Class II on ISCs via the Microbiome	34
On-Target BTK Mutations Promote Resistance to Noncovalent BTK Inhibitors	33
BTK Inhibitor Options Expand for CLL/SLL	33
HSCT Chemotherapy Supports Peripheral Macrophage Engraftment of the Brain	33
Altered tRNA Isoacceptor Abundance Regulates Breast Cancer Metastasis	33
Senescent Cancer Cells Are Vulnerable to Extrinsic Apoptosis Pathway Activation	33
Noted	33
High-Endothelial Venules Promote Permissive T-cell Niches after Immunotherapy	33
In This Issue	32
Driver Events of Gastric Cancer Differ According to Subtype and Ancestry	32
Correction: Creating MHC-Restricted Neoantigens with Covalent Inhibitors That Can Be Targeted by Immune Therapy	32
Nociceptor Neurons Affect Immunosurveillance and Tumor Growth	32
Disruption of KAT8–IRF1 Condensate Formation Reduces PD-L1 Expression	32
Y Chromosome Loss Drives Bladder Cancer Aggressiveness and Immune Evasion	32
Correction: Highlights of FDA Oncology Approvals in 2023: Bispecific T-cell Engagers, Pediatric Indications, and Inclusive Drug Development	32
PHGDH Inhibition Overcomes Glioblastoma Resistance to T-cell Therapy	32
Primary, Metastatic Tumors Vary Genomically by Cancer Type	31
Correction: Animal Alternatives OK'd by New Law	31
Gut Microbiota Regulate PD-L2 Expression and Immunotherapy Response	31
Intrinsically Disordered Regions Control cBAF Condensation and Interactions	31
Mitochondrial Glutathione Import Enables Breast Cancer Metastasis via Integrated Stress Response Signaling	30
Dangerous Liaisons betweenTet2Mutation, Inflammatory Monocytes, and Leukemogenesis	30
Artificial Intelligence Identifies Novel Disease Pathways	30
Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer	30
Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants	30
Receptor-interacting Protein Kinase 2 Is an Immunotherapy Target in Pancreatic Cancer	29
Immunogenicity and Efficacy of Personalized Adjuvant mRNA Cancer Vaccines	29
The Origin of Highly Elevated Cell-Free DNA in Healthy Individuals and Patients with Pancreatic, Colorectal, Lung, or Ovarian Cancer	29
Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection	29
Germline–Somatic Liaison Dictates Cancer Subtypes via de novo Steroid Biosynthesis	28
Dual Immunotherapy Makes Strides against HCC	28
Cell States in Cancer: Drivers, Passengers, and Trailers	28
Mutant IDH Inhibits IFNγ–TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma	28
Tackling Cancer through Global Team Science	28
The SCRUM-MONSTAR Cancer-Omics Ecosystem: Striving for a Quantum Leap in Precision Medicine	28