OOIR: Observatory of International Research

Papers

(The H4-Index of Cancer Discovery is 82. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Drafting a Blueprint for European Cancer Research	7268
Highlighted research articles	779
Low-Glycemic Diets Restrict Tumor Growth through Altered Lipid Metabolism	393
Q&A: Philip Greenberg on T Cells, IO's Future	290
HLA-E:CD94–NKG2A Mediates Circulating Tumor Cell Immune Evasion	262
AI-Supported Mammography “Safe,” Cuts Workload	260
Mutation-Driven Alveolar Cell Reprogramming Dictates Lung Cancer Progression	251
Succinyl-CoA and Cobalamin Are Biomarkers That Improve Anal Cancer Screening	245
Human Tumor Cells Display an Oncogene-like Addiction to Aneuploidy	236
Probing Clonal Hematopoiesis in Liquid Biopsy	230
Shattered Chromosomes Undergo Mitotic Tethering during Chromothripsis	208
PARADIGM Identifies Associations between Drugs, the Microbiome, and Mortality	192
Air Pollution Promotes Oncogenic Expansion of Mutant Lung Progenitor Cells	189
Selpercatinib Shifts Treatment Paradigm for MTC and NSCLC	188
Correction: Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer	180
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission	178
Highlighted research articles	170
Proteostasis Network Modulation Promotes Resistance to KRAS Inhibitors	167
An NK-cell Therapy for CD30+ Lymphomas	167
Lymph Node Metastasis Induces Immune Tolerance and Distant Metastasis	152
RAS Drives Malignancy through Altered Stem Cell/Microenvironment Cross-talk	148
Combination Diagnostics: Adding Blood-Based ctDNA Screening to Low-Dose CT Imaging for Early Detection of Lung Cancer	145
Trispecifics Improve Immune-Cell Engagement	145
IL7 Genetic Variation Predicts Immune-Related Adverse Events	145
GIST: Molecular Profiling Suggests 2nd Therapy	144

Exome Sequencing IDs Hidden Disease Variants	142
Collagen Receptor Implicated in Immune Exclusion	139
Structure of the Tumor Stroma Predicts Invasive Breast Cancer Relapse	139
Dendritic Cell Circadian Rhythm Governs the Antitumor Immune Response	139
Intrinsic Properties of the Lymph Node Render It Immunologically Susceptible to Metastasis	137
PIN1 Prolyl Isomerase Promotes Initiation and Progression of Bladder Cancer through the SREBP2-Mediated Cholesterol Biosynthesis Pathway	136
A Guide to Extrachromosomal DNA: Cancer’s Dynamic Circular Genome	135
Convergence of Targeted and Immune Therapies for the Treatment of Oncogene-Driven Cancers	133
Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma	132
Adjuvant PD-1 Blockade in Resected Melanoma: Is Preventing Recurrence Enough?	128
REFLECTions on Combination Therapies Empowered by Data Sharing	127
Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta	122
Gut Microbiota Modulation through Akkermansia spp . Supplementation Increases CAR T-cell Potency	120
Cytosolic Phospholipase A2 Determines Intercellular Heterogeneity of Stress Granules and Chemotherapy Response	119
Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma	118
Rational Protein Engineering to Enhance MHC-Independent T-cell Receptors	118
p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression	117
Transposable Element Signatures Define Stages of T-cell Exhaustion	115
A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy	114
Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression	113
The Dark Side of NK Cells in Cancer Immunotherapy	112
CHD2 Regulates Neuron–Glioma Interactions in Pediatric Glioma	110
The 3D Revolution in Cancer Discovery	109
Presurgery Plus Postsurgery Immunotherapy Ups Survival in NSCLC	108
New Strategy May Thwart Glioblastoma Resistance	105
FMRP Depletion Reprograms an Immunosuppressive Microenvironment	103
Tumor-Derived Extracellular Vesicles and Particles Inhibit Liver Function	102
The Proteasome Regulator PSME4 Modulates Antitumor Immunity	102
In This Issue	101
Multicellular Spatial Organization Determines Immunotherapy Response	101
Chronic Inflammation Drives TP53-Mutant Leukemic Evolution	101
Response to Low Antigen Density Is Improved by HLA-Independent T-cell Receptors	100
What's Next for Sotorasib in NSCLC?	99
Revumenib Is Safe and Efficacious, but MEN1 Mutations Mediate Resistance	99
Noninvasive and Multicancer Biomarkers: The Promise of LINE-1 Retrotransposons	96
Aged Lungs Enable Metastatic Outgrowth of Dormant Melanoma Cells	96
Beneath the Surface: Neoantigens beyond Chromosomal DNA Mutations	95
In This Issue	95
Cancer in the Prime of Life: Etiologic Insights and Supportive Oncologic Interventions for the Rising Burden of Young Adult Cancer	95
Akk Abundance Alters Survival in Patients with NSCLC on ICIs	95
TILs Outperform Ipilimumab in Melanoma	94
Hyperactivation of Oncogenic Pathways Hinders Cancer Cell Survival	93
Lymph Node–Specific IFNγ Levels Affect CD8+ T-cell Priming against Tumors	92
Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy	91
Atypical Small Cell Lung Cancer: A New Malignancy Characterized by Chromothripsis, Carcinoid Tumors, and Wild-type RB1 and TP53	91
Bridging the Gap between Diseases of the Stomach and Lower Esophagus	90
Moving Spatially Resolved Multiplexed Protein Profiling toward Clinical Oncology	90
Intestinal Microbiome Inhibits CD8+ T Cells via the Calcineurin–NFAT Axis	89
Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Protumorigenic T-cell Polarization	89
A Molecular Voyage: Multiomics Insights into Circulating Tumor Cells	86

AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer	85
Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth	84
Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer	83
The Kinase Module of the Mediator Complex Inhibits CAR T-cell Function	82
Temozolomide Treatment Alters Mismatch Repair and Boosts Mutational Burden in Tumor and Blood of Colorectal Cancer Patients	82
Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity	82
NRF2: KEAPing Tumors Protected	82