OOIR: Observatory of International Research

Papers

(The H4-Index of Cancer Discovery is 82. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Drafting a Blueprint for European Cancer Research	6876
Highlighted research articles	729
Low-Glycemic Diets Restrict Tumor Growth through Altered Lipid Metabolism	371
Mouse Models Provide Insight into Factors Affecting BiTE Efficacy	267
Q&A: Philip Greenberg on T Cells, IO's Future	257
HLA-E:CD94–NKG2A Mediates Circulating Tumor Cell Immune Evasion	240
AI-Supported Mammography “Safe,” Cuts Workload	237
Mutation-Driven Alveolar Cell Reprogramming Dictates Lung Cancer Progression	235
Succinyl-CoA and Cobalamin Are Biomarkers That Improve Anal Cancer Screening	223
Human Tumor Cells Display an Oncogene-like Addiction to Aneuploidy	218
Probing Clonal Hematopoiesis in Liquid Biopsy	216
Shattered Chromosomes Undergo Mitotic Tethering during Chromothripsis	214
PARADIGM Identifies Associations between Drugs, the Microbiome, and Mortality	199
Air Pollution Promotes Oncogenic Expansion of Mutant Lung Progenitor Cells	179
Selpercatinib Shifts Treatment Paradigm for MTC and NSCLC	179
Correction: Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer	172
REFLECTions on Combination Therapies Empowered by Data Sharing	167
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission	164
Highlighted research articles	159
Proteostasis Network Modulation Promotes Resistance to KRAS Inhibitors	156
Adjuvant PD-1 Blockade in Resected Melanoma: Is Preventing Recurrence Enough?	144
Structure of the Tumor Stroma Predicts Invasive Breast Cancer Relapse	141
Dendritic Cell Circadian Rhythm Governs the Antitumor Immune Response	139
Convergence of Targeted and Immune Therapies for the Treatment of Oncogene-Driven Cancers	136
Cytosolic Phospholipase A2 Determines Intercellular Heterogeneity of Stress Granules and Chemotherapy Response	134

p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression	134
IL7 Genetic Variation Predicts Immune-Related Adverse Events	133
Transposable Element Signatures Define Stages of T-cell Exhaustion	133
Combination Diagnostics: Adding Blood-Based ctDNA Screening to Low-Dose CT Imaging for Early Detection of Lung Cancer	131
Trispecifics Improve Immune-Cell Engagement	131
Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta	131
Intrinsic Properties of the Lymph Node Render It Immunologically Susceptible to Metastasis	130
RAS Drives Malignancy through Altered Stem Cell/Microenvironment Cross-talk	129
Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma	129
GIST: Molecular Profiling Suggests 2nd Therapy	128
Exome Sequencing IDs Hidden Disease Variants	127
Rational Protein Engineering to Enhance MHC-Independent T-cell Receptors	126
Collagen Receptor Implicated in Immune Exclusion	124
Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression	123
An NK-cell Therapy for CD30+ Lymphomas	123
PIN1 Prolyl Isomerase Promotes Initiation and Progression of Bladder Cancer through the SREBP2-Mediated Cholesterol Biosynthesis Pathway	120
The 3D Revolution in Cancer Discovery	118
A Guide to Extrachromosomal DNA: Cancer’s Dynamic Circular Genome	116
Gut Microbiota Modulation through Akkermansia spp. Supplementation Increases CAR T-cell Potency	115
CHD2 Regulates Neuron–Glioma Interactions in Pediatric Glioma	113
Lymph Node Metastasis Induces Immune Tolerance and Distant Metastasis	113
Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma	112
The Dark Side of NK Cells in Cancer Immunotherapy	111
A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy	109
New Strategy May Thwart Glioblastoma Resistance	109
Presurgery Plus Postsurgery Immunotherapy Ups Survival in NSCLC	109
FMRP Depletion Reprograms an Immunosuppressive Microenvironment	107
The Proteasome Regulator PSME4 Modulates Antitumor Immunity	105
Tumor-Derived Extracellular Vesicles and Particles Inhibit Liver Function	105
Chronic Inflammation Drives TP53-Mutant Leukemic Evolution	103
Multicellular Spatial Organization Determines Immunotherapy Response	99
In This Issue	99
Revumenib Is Safe and Efficacious, but MEN1 Mutations Mediate Resistance	96
Response to Low Antigen Density Is Improved by HLA-Independent T-cell Receptors	96
Aged Lungs Enable Metastatic Outgrowth of Dormant Melanoma Cells	95
What's Next for Sotorasib in NSCLC?	95
Noninvasive and Multicancer Biomarkers: The Promise of LINE-1 Retrotransposons	94
Bridging the Gap between Diseases of the Stomach and Lower Esophagus	94
Beneath the Surface: Neoantigens beyond Chromosomal DNA Mutations	93
Harnessing Mitochondrial Mutations to ATAC Clonal Evolution in CLL	92
A Molecular Voyage: Multiomics Insights into Circulating Tumor Cells	92
Akk Abundance Alters Survival in Patients with NSCLC on ICIs	91
Cancer in the Prime of Life: Etiologic Insights and Supportive Oncologic Interventions for the Rising Burden of Young Adult Cancer	89
In This Issue	89
TILs Outperform Ipilimumab in Melanoma	88
Hyperactivation of Oncogenic Pathways Hinders Cancer Cell Survival	87
Lymph Node–Specific IFNγ Levels Affect CD8+ T-cell Priming against Tumors	86
Atypical Small Cell Lung Cancer: A New Malignancy Characterized by Chromothripsis, Carcinoid Tumors, and Wild-type RB1 and TP53	85
Moving Spatially Resolved Multiplexed Protein Profiling toward Clinical Oncology	85
Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity	85

Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer	85
Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy	84
New Immunotherapy Combinations Enter the Battlefield of Malignant Mesothelioma	84
Rlf–Mycl Gene Fusion Drives Tumorigenesis and Metastasis in a Mouse Model of Small Cell Lung Cancer	83
Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Protumorigenic T-cell Polarization	83
Temozolomide Treatment Alters Mismatch Repair and Boosts Mutational Burden in Tumor and Blood of Colorectal Cancer Patients	83
Intestinal Microbiome Inhibits CD8+ T Cells via the Calcineurin–NFAT Axis	83