OOIR: Observatory of International Research

Papers

(The H4-Index of Cancer Discovery is 81. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Drafting a Blueprint for European Cancer Research	367
Highlighted research articles	350
Q&A: Philip Greenberg on T Cells, IO's Future	328
AI-Supported Mammography “Safe,” Cuts Workload	318
Mutation-Driven Alveolar Cell Reprogramming Dictates Lung Cancer Progression	301
Succinyl-CoA and Cobalamin Are Biomarkers That Improve Anal Cancer Screening	300
Human Tumor Cells Display an Oncogene-like Addiction to Aneuploidy	258
Probing Clonal Hematopoiesis in Liquid Biopsy	251
Shattered Chromosomes Undergo Mitotic Tethering during Chromothripsis	211
PARADIGM Identifies Associations between Drugs, the Microbiome, and Mortality	208
Highlighted research articles	206
Proteostasis Network Modulation Promotes Resistance to KRAS Inhibitors	204
RAS Drives Malignancy through Altered Stem Cell/Microenvironment Cross-talk	202
IL7 Genetic Variation Predicts Immune-Related Adverse Events	195
Convergence of Targeted and Immune Therapies for the Treatment of Oncogene-Driven Cancers	189
Reversing Immune Aging to Improve Immunotherapy Outcomes	188
Disrupting MYC RNA Interactions Promotes Tumor Regression	180
GIST: Molecular Profiling Suggests 2nd Therapy	172
Transposable Element Signatures Define Stages of T-cell Exhaustion	165
Correction: Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer	159
Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma	156
Air Pollution Promotes Oncogenic Expansion of Mutant Lung Progenitor Cells	155
Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta	154
Combination Diagnostics: Adding Blood-Based ctDNA Screening to Low-Dose CT Imaging for Early Detection of Lung Cancer	153
Selpercatinib Shifts Treatment Paradigm for MTC and NSCLC	153

Liver Response to Metabolic Stress Drives Cancer-associated Programs	153
HLA-E:CD94–NKG2A Mediates Circulating Tumor Cell Immune Evasion	152
Rational Protein Engineering to Enhance MHC-Independent T-cell Receptors	149
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission	149
Cytosolic Phospholipase A2 Determines Intercellular Heterogeneity of Stress Granules and Chemotherapy Response	147
Modular Platform Curbs CAR T-Cell Exhaustion by Tuning Receptor Shedding	144
Dendritic Cell Circadian Rhythm Governs the Antitumor Immune Response	138
A Guide to Extrachromosomal DNA: Cancer’s Dynamic Circular Genome	134
Nonprofit Acquires Abandoned Leukemia Drug Supply	133
A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy	131
PIN1 Prolyl Isomerase Promotes Initiation and Progression of Bladder Cancer through the SREBP2-Mediated Cholesterol Biosynthesis Pathway	130
p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression	128
CHD2 Regulates Neuron–Glioma Interactions in Pediatric Glioma	128
Circulating Tumor Cells Predict Response to the DLL3-Targeting Bispecific Antibody Tarlatamab	123
Intrinsic Properties of the Lymph Node Render It Immunologically Susceptible to Metastasis	123
The 3D Revolution in Cancer Discovery	121
The Dark Side of NK Cells in Cancer Immunotherapy	121
Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression	120
Therapy-Related Mutational Signatures in Subsequent Neoplasms among Survivors of Childhood Cancer	119
Longitudinal Plasma Metabolomics Guides Dynamic Risk Assessment and Dietary Modulation for Esophageal Squamous Cell Cancer Chemoimmunotherapy	118
Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma	117
Gut Microbiota Modulation through Akkermansia spp . Supplementation Increases CAR T-cell Potency	116
Presurgery Plus Postsurgery Immunotherapy Ups Survival in NSCLC	115
New Strategy May Thwart Glioblastoma Resistance	113
The Proteasome Regulator PSME4 Modulates Antitumor Immunity	111
FMRP Depletion Reprograms an Immunosuppressive Microenvironment	111
Chronic Inflammation Drives TP53-Mutant Leukemic Evolution	110
Tumor-Derived Extracellular Vesicles and Particles Inhibit Liver Function	110
Multicellular Spatial Organization Determines Immunotherapy Response	109
Revumenib Is Safe and Efficacious, but MEN1 Mutations Mediate Resistance	108
Aged Lungs Enable Metastatic Outgrowth of Dormant Melanoma Cells	103
What's Next for Sotorasib in NSCLC?	103
Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Protumorigenic T-cell Polarization	102
Moving Spatially Resolved Multiplexed Protein Profiling toward Clinical Oncology	101
TILs Outperform Ipilimumab in Melanoma	99
In This Issue	99
Hyperactivation of Oncogenic Pathways Hinders Cancer Cell Survival	97
Lymph Node–Specific IFNγ Levels Affect CD8+ T-cell Priming against Tumors	97
Bridging the Gap between Diseases of the Stomach and Lower Esophagus	96
Landmark Pediatric Cancer Legislation Aims to Incentivize Research	96
Noninvasive and Multicancer Biomarkers: The Promise of LINE-1 Retrotransposons	96
Beneath the Surface: Neoantigens beyond Chromosomal DNA Mutations	95
Cancer in the Prime of Life: Etiologic Insights and Supportive Oncologic Interventions for the Rising Burden of Young Adult Cancer	94
Multimodal AI Model Predicts Breast Cancer Recurrence	93
Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy	92
A Molecular Voyage: Multiomics Insights into Circulating Tumor Cells	91
Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer	90
Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity	88
mtDNA Lineage Tracing Reveals Monocyte Fate Bias Prior to Tumor Infiltration	86
Myofibroblasts Induce Neuroplasticity to Promote Pancreatic Inflammation and Cancer Progression	85

Atypical Small Cell Lung Cancer: A New Malignancy Characterized by Chromothripsis, Carcinoid Tumors, and Wild-type RB1 and TP53	85
Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth	85
A pan-cancer single-cell analysis of intratumoral copy number diversity and evolution	85
EML4-ALK mediates resistance to KRAS G12C inhibition and induces an oncogenic dependency by rewiring signaling through the wild-type RAS pathway	84
The Moving Target: Cis -Mutation–Driven Resistance to p53-Y220C Reactivator	82
The Kinase Module of the Mediator Complex Inhibits CAR T-cell Function	82