OOIR: Observatory of International Research

Papers

(The TQCC of Oncogenesis is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Gemcitabine as chemotherapy of head and neck cancer in Fanconi anemia patients	197
NUCKS1 promotes invasion and metastasis of colorectal cancer by stabilizing HDAC2 and activating AKT	128
A HOTAIR-associated super-enhancer orchestrates glioblastoma malignancy via MEST	66
Noncanonical PRC1.1 targets BTG2 to retain cyclin gene expression and cell growth in neuroblastoma	55
Vortioxetine hydrobromide inhibits the growth of gastric cancer cells in vivo and in vitro by targeting JAK2 and SRC	54
USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c	54
Discovery of neddylation E2s inhibitors with therapeutic activity	52
PELI1 and EGFR cooperate to promote breast cancer metastasis	46
Correction: Overexpression of SMC4 activates TGFβ/Smad signaling and promotes aggressive phenotype in glioma cells	43
Targeted metabolomics detects a putatively diagnostic signature in plasma and dried blood spots from head and neck paraganglioma patients	36
P4HB maintains Wnt-dependent stemness in glioblastoma stem cells as a precision therapeutic target and serum marker	35
Biological differences underlying sex and gender disparities in bladder cancer: current synopsis and future directions	32
PLEKHA4 is transcriptionally regulated by HOXD9 and regulates glycolytic reprogramming and progression in glioblastoma via activation of the STAT3/SOCS-1 pathway	31
Correction: Mitochondrial dysfunction and impaired growth of glioblastoma cell lines caused by antimicrobial agents inducing ferroptosis under glucose starvation	29
Calreticulin enhances gastric cancer metastasis by dimethylating H3K9 in the E-cadherin promoter region mediating by G9a	29
UHRF1 overexpression promotes osteosarcoma metastasis through altered exosome production and AMPK/SEMA3E suppression	29
Spindle function and Wnt pathway inhibition by PBX1 to suppress tumor progression via downregulating DCDC2 in colorectal cancer	28
Involvement of the pro-oncogenic enzyme fatty acid synthase in the hallmarks of cancer: a promising target in anti-cancer therapies	27
USP35 promotes cell proliferation and chemotherapeutic resistance through stabilizing FUCA1 in colorectal cancer	25
Breast cancer in the era of integrating “Omics” approaches	25
Ablation of sphingosine kinase 2 suppresses fatty liver-associated hepatocellular carcinoma via downregulation of ceramide transfer protein	25
Exosomes and cancer - Diagnostic and prognostic biomarkers and therapeutic vehicle	24
Preneoplastic cells switch to Warburg metabolism from their inception exposing multiple vulnerabilities for targeted elimination	24
STAG2 expression imparts distinct therapeutic vulnerabilities in muscle-invasive bladder cancer cells	23
Collagen type IV alpha 6 promotes tumor progression and chemoresistance in ovarian cancer by activating the discoidin domain receptor 1 pathway	22

PFKFB4 interacts with FBXO28 to promote HIF-1α signaling in glioblastoma	21
FLT4 activation promotes acute lymphoid leukemia survival through stabilization of MDM2/MDMX and inactivation of p53	21
CCND3 is indispensable for the maintenance of B-cell acute lymphoblastic leukemia	21
Coordinate transcriptional regulation of ErbB2/3 by C-terminal binding protein 2 signals sensitivity to ErbB2 inhibition in pancreatic adenocarcinoma	20
An E3 ligase TRIM1 promotes colorectal cancer progression via K63-linked ubiquitination and activation of HIF1α	19
SLC26A3/NHERF2-IκB/NFκB/p65 feedback loop suppresses tumorigenesis and metastasis in colorectal cancer	19
Diltiazem inhibits breast cancer metastasis via mediating growth differentiation factor 15 and epithelial-mesenchymal transition	19
Correction: Heterogeneity of subsets in glioblastoma mediated by Smad3 palmitoylation	19
Anti-PD-1 therapy achieves favorable outcomes in HBV-positive non-liver cancer	19
Transgelin promotes lung cancer progression via activation of cancer-associated fibroblasts with enhanced IL-6 release	18
Analysis of the metabolic proteome of lung adenocarcinomas by reverse-phase protein arrays (RPPA) emphasizes mitochondria as targets for therapy	17
WDR5 facilitates recruitment of N-MYC to conserved WDR5 gene targets in neuroblastoma cell lines	17
NAC1 transcriptional activation of LDHA induces hepatitis B virus immune evasion leading to cirrhosis and hepatocellular carcinoma development	17
Comprehensive multi-omics analysis of breast cancer reveals distinct long-term prognostic subtypes	17
Involvement of Kindlin-1 in cutaneous squamous cell carcinoma	17
ACT001 inhibited CD133 transcription by targeting and inducing Olig2 ubiquitination degradation	16
HLTF promotes hepatocellular carcinoma progression by enhancing SRSF1 stability and activating ERK/MAPK pathway	16
Subtype-specific role for Jagged1 in promoting or inhibiting breast tumor formation	16
Generating in vitro models of NTRK-fusion mesenchymal neoplasia as tools for investigating kinase oncogenic activation and response to targeted therapy	16
TGF-β signaling redirects Sox11 gene regulatory activity to promote partial EMT and collective invasion of oncogenically transformed intestinal organoids	16
Targeting macrophage migration inhibitory factor as a potential therapeutic strategy in colorectal cancer	16
Loss of MBD2 attenuates MLL-AF9-driven leukemogenesis by suppressing the leukemic cell cycle via CDKN1C	15
Aberrant APOBEC3C expression induces characteristic genomic instability in pancreatic ductal adenocarcinoma	15
WDR4 promotes the progression and lymphatic metastasis of bladder cancer via transcriptional down-regulation of ARRB2	15
Co-activation of Sonic hedgehog and Wnt signaling in murine retinal precursor cells drives ocular lesions with features of intraocular medulloepithelioma	14
Correction: Non-enzymatic heparanase enhances gastric tumor proliferation via TFEB-dependent autophagy	14
Correction: Targeting IL-3Rα on tumor-derived endothelial cells blunts metastatic spread of triple-negative breast cancer via extracellular vesicle reprogramming	14
Correction: PBK phosphorylates MSL1 to elicit epigenetic modulation of CD276 in nasopharyngeal carcinoma	14
LUBAC promotes angiogenesis and lung tumorigenesis by ubiquitinating and antagonizing autophagic degradation of HIF1α	14
Correction: Tumor-derived exosomes induce PD1+ macrophage population in human gastric cancer that promotes disease progression	13
CD147-high extracellular vesicles promote gastric cancer metastasis via VEGF/AKT/eNOS and AKT/mTOR pathways	13