OOIR: Observatory of International Research

Papers

(The median citation count of Oncogenesis is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
MYB oncoproteins: emerging players and potential therapeutic targets in human cancer	101
Exosomes and cancer - Diagnostic and prognostic biomarkers and therapeutic vehicle	99
Single-cell RNA sequencing reveals cell heterogeneity and transcriptome profile of breast cancer lymph node metastasis	83
Understanding the common mechanisms of heart and skeletal muscle wasting in cancer cachexia	70
Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance	70
TGF-β1-mediated transition of resident fibroblasts to cancer-associated fibroblasts promotes cancer metastasis in gastrointestinal stromal tumor	60
Metformin exhibits antiproliferation activity in breast cancer via miR-483-3p/METTL3/m6A/p21 pathway	53
miR-18a promotes glioblastoma development by down-regulating ALOXE3-mediated ferroptotic and anti-migration activities	52
RETRACTED ARTICLE: PI3K/Akt pathway and Nanog maintain cancer stem cells in sarcomas	47
IL-6 promotes drug resistance through formation of polyploid giant cancer cells and stromal fibroblast reprogramming	43
LONP1 and ClpP cooperatively regulate mitochondrial proteostasis for cancer cell survival	39
Diethyldithiocarbamate-copper complex (CuET) inhibits colorectal cancer progression via miR-16-5p and 15b-5p/ALDH1A3/PKM2 axis-mediated aerobic glycolysis pathway	38
Triptolide targets super-enhancer networks in pancreatic cancer cells and cancer-associated fibroblasts	38
USP29-mediated HIF1α stabilization is associated with Sorafenib resistance of hepatocellular carcinoma cells by upregulating glycolysis	37
YAP/TAZ inhibition reduces metastatic potential of Ewing sarcoma cells	34
Dissecting the single-cell transcriptome network in patients with esophageal squamous cell carcinoma receiving operative paclitaxel plus platinum chemotherapy	32
Feedback activation of STAT3 limits the response to PI3K/AKT/mTOR inhibitors in PTEN-deficient cancer cells	32
Breast cancer in the era of integrating “Omics” approaches	30
Epigenetic regulation of TGF-β-induced EMT by JMJD3/KDM6B histone H3K27 demethylase	29
Neutrophils and polymorphonuclear myeloid-derived suppressor cells: an emerging battleground in cancer therapy	29
Angiogenesis and immune checkpoint dual blockade in combination with radiotherapy for treatment of solid cancers: opportunities and challenges	28
Emerging role of SWI/SNF complex deficiency as a target of immune checkpoint blockade in human cancers	27
Involvement of the pro-oncogenic enzyme fatty acid synthase in the hallmarks of cancer: a promising target in anti-cancer therapies	27
OXER1 and RACK1-associated pathway: a promising drug target for breast cancer progression	27
Tumor-secreted exosomal Wnt2B activates fibroblasts to promote cervical cancer progression	26

Tumour heterogeneity and evolutionary dynamics in colorectal cancer	26
Functional screening identifies aryl hydrocarbon receptor as suppressor of lung cancer metastasis	25
TRPC1 promotes the genesis and progression of colorectal cancer via activating CaM-mediated PI3K/AKT signaling axis	24
EHF suppresses cancer progression by inhibiting ETS1-mediated ZEB expression	24
CXCL12/CXCR4 axis supports mitochondrial trafficking in tumor myeloma microenvironment	23
Hypoxia promotes an inflammatory phenotype of fibroblasts in pancreatic cancer	23
Emerging role of G9a in cancer stemness and promises as a therapeutic target	22
MiR-22, regulated by MeCP2, suppresses gastric cancer cell proliferation by inducing a deficiency in endogenous S-adenosylmethionine	22
Inactivation of the CIC-DUX4 oncogene through P300/CBP inhibition, a therapeutic approach for CIC-DUX4 sarcoma	22
Fusion protein-driven IGF-IR/PI3K/AKT signals deregulate Hippo pathway promoting oncogenic cooperation of YAP1 and FUS-DDIT3 in myxoid liposarcoma	21
PRMT6 activates cyclin D1 expression in conjunction with the transcription factor LEF1	20
Non-metabolic role of UCK2 links EGFR-AKT pathway activation to metastasis enhancement in hepatocellular carcinoma	20
Tumour cells express functional lymphatic endothelium-specific hyaluronan receptor in vitro and in vivo: Lymphatic mimicry promotes oral oncogenesis?	20
Elevated ATGL in colon cancer cells and cancer stem cells promotes metabolic and tumorigenic reprogramming reinforced by obesity	20
Musashi-2 (MSI2) regulates epidermal growth factor receptor (EGFR) expression and response to EGFR inhibitors in EGFR-mutated non-small cell lung cancer (NSCLC)	20
Fatty acid transport protein-5 (FATP5) deficiency enhances hepatocellular carcinoma progression and metastasis by reprogramming cellular energy metabolism and regulating the AMPK-mTOR signaling pathwa	20
Inhibition of Bruton’s tyrosine kinase as a therapeutic strategy for chemoresistant oral squamous cell carcinoma and potential suppression of cancer stemness	20
The mechanical phenotypic plasticity of melanoma cell: an emerging driver of therapy cross-resistance	19
PBK phosphorylates MSL1 to elicit epigenetic modulation of CD276 in nasopharyngeal carcinoma	19
SIAH1 reverses chemoresistance in epithelial ovarian cancer via ubiquitination of YBX-1	19
NNMT promotes the progression of intrahepatic cholangiocarcinoma by regulating aerobic glycolysis via the EGFR-STAT3 axis	18
E2F1 and epigenetic modifiers orchestrate breast cancer progression by regulating oxygen-dependent ESRP1 expression	18
Evolution of HER2-positive mammary carcinoma: HER2 loss reveals claudin-low traits in cancer progression	17
Heterogeneity of subsets in glioblastoma mediated by Smad3 palmitoylation	17
Sulfated alginate oligosaccharide exerts antitumor activity and autophagy induction by inactivating MEK1/ERK/mTOR signaling in a KSR1-dependent manner in osteosarcoma	17
A novel dual HDAC and HSP90 inhibitor, MPT0G449, downregulates oncogenic pathways in human acute leukemia in vitro and in vivo	17
Disruption of STAT5A and NMI signaling axis leads to ISG20-driven metastatic mammary tumors	17
Resistance to BET inhibitors in lung adenocarcinoma is mediated by casein kinase phosphorylation of BRD4	17
Estradiol-mediated inhibition of DNMT1 decreases p53 expression to induce M2-macrophage polarization in lung cancer progression	17
PSMC2 promotes the progression of gastric cancer via induction of RPS15A/mTOR pathway	16
EZH2 facilitates BMI1-dependent hepatocarcinogenesis through epigenetically silencing microRNA-200c	16
YWHAE-NUTM2 oncoprotein regulates proliferation and cyclin D1 via RAF/MAPK and Hippo pathways	15
TGFβ/cyclin D1/Smad-mediated inhibition of BMP4 promotes breast cancer stem cell self-renewal activity	15
Connexin 43 confers chemoresistance through activating PI3K	15
C20orf204, a hepatocellular carcinoma-specific protein interacts with nucleolin and promotes cell proliferation	15
The E3 ubiquitin ligase MG53 inhibits hepatocellular carcinoma by targeting RAC1 signaling	15
Loss of p53 suppresses replication stress-induced DNA damage in ATRX-deficient neuroblastoma	15
CCT8 recovers WTp53-suppressed cell cycle evolution and EMT to promote colorectal cancer progression	15
Kras activation in endometrial organoids drives cellular transformation and epithelial-mesenchymal transition	14
The prohibitin-binding compound fluorizoline inhibits mitophagy in cancer cells	14
Disruptor of telomeric silencing 1-like promotes ovarian cancer tumor growth by stimulating pro-tumorigenic metabolic pathways and blocking apoptosis	14
USP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer	14
Precision modeling of gall bladder cancer patients in mice based on orthotopic implantation of organoid-derived tumor buds	14
UHRF1 overexpression promotes osteosarcoma metastasis through altered exosome production and AMPK/SEMA3E suppression	14
Ablation of sphingosine kinase 2 suppresses fatty liver-associated hepatocellular carcinoma via downregulation of ceramide transfer protein	13
Biological differences underlying sex and gender disparities in bladder cancer: current synopsis and future directions	13
Prolactin receptor-driven combined luminal and epithelial differentiation in breast cancer restricts plasticity, stemness, tumorigenesis and metastasis	13
GSK3β palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2–STAT3 axis	12
CARD10 cleavage by MALT1 restricts lung carcinoma growth in vivo	12
Metabolic guidance and stress in tumors modulate antigen-presenting cells	12

The metastasis suppressor protein NM23-H1 modulates the PI3K-AKT axis through interaction with the p110α catalytic subunit	12
Tumor suppressor p53 restrains cancer cell dissemination by modulating mitochondrial dynamics	12
MMP8 increases tongue carcinoma cell–cell adhesion and diminishes migration via cleavage of anti-adhesive FXYD5	12
FAM83B inhibits ovarian cancer cisplatin resistance through inhibiting Wnt pathway	11
Salt-Inducible Kinase 1 is a potential therapeutic target in Desmoplastic Small Round Cell Tumor	11
Suppression of 4.1R enhances the potency of NKG2D-CAR T cells against pancreatic carcinoma via activating ERK signaling pathway	11
Neuron-specific enolase promotes stem cell-like characteristics of small-cell lung cancer by downregulating NBL1 and activating the BMP2/Smad/ID1 pathway	11
AKT1 regulates UHRF1 protein stability and promotes the resistance to abiraterone in prostate cancer	11
MicroRNA-21 is immunosuppressive and pro-metastatic via separate mechanisms	11
Tripartite motif-containing 3 (TRIM3) enhances ER signaling and confers tamoxifen resistance in breast cancer	11
MYCN induces cell-specific tumorigenic growth in RB1-proficient human retinal organoid and chicken retina models of retinoblastoma	11
PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer	11
ZNF655 accelerates progression of pancreatic cancer by promoting the binding of E2F1 and CDK1	11
RNF8 ubiquitinates RecQL4 and promotes its dissociation from DNA double strand breaks	11
Mitochondrial dysfunction and impaired growth of glioblastoma cell lines caused by antimicrobial agents inducing ferroptosis under glucose starvation	10
Cdk5 drives formation of heterogeneous pancreatic neuroendocrine tumors	10
Aberrant APOBEC3C expression induces characteristic genomic instability in pancreatic ductal adenocarcinoma	10
PLEKHA5 regulates the survival and peritoneal dissemination of diffuse-type gastric carcinoma cells with Met gene amplification	10
Molecular mechanisms in colitis-associated colorectal cancer	10
A novel uterine leiomyoma subtype exhibits NRF2 activation and mutations in genes associated with neddylation of the Cullin 3-RING E3 ligase	10
Single-cell RNA sequencing reveals that targeting HSP90 suppresses PDAC progression by restraining mitochondrial bioenergetics	10
Overexpression of glycosyltransferase 8 domain containing 2 confers ovarian cancer to CDDP resistance by activating FGFR/PI3K signalling axis	10
The HLTF–PARP1 interaction in the progression and stability of damaged replication forks caused by methyl methanesulfonate	10
High expression of PSMC2 promotes gallbladder cancer through regulation of GNG4 and predicts poor prognosis	10
Guanylate-binding proteins induce apoptosis of leukemia cells by regulating MCL-1 and BAK	9
PFKFB4 interacts with FBXO28 to promote HIF-1α signaling in glioblastoma	9
Tumor-derived miR-130b-3p induces cancer-associated fibroblast activation by targeting SPIN90 in luminal A breast cancer	9
Methylation of HBP1 by PRMT1 promotes tumor progression by regulating actin cytoskeleton remodeling	9
Diltiazem inhibits breast cancer metastasis via mediating growth differentiation factor 15 and epithelial-mesenchymal transition	9
Cytoglobin attenuates pancreatic cancer growth via scavenging reactive oxygen species	9
ARNT deficiency represses pyruvate dehydrogenase kinase 1 to trigger ROS production and melanoma metastasis	9
GP73-mediated secretion of AFP and GP73 promotes proliferation and metastasis of hepatocellular carcinoma cells	9
Clathrin adapters AP-1 and GGA2 support expression of epidermal growth factor receptor for cell growth	9
C1GALT1 expression predicts a favorable prognosis and suppresses malignant phenotypes via TrkA signaling in neuroblastoma	8
A CRISPR knockout screen reveals new regulators of canonical Wnt signaling	8
Analysis of the metabolic proteome of lung adenocarcinomas by reverse-phase protein arrays (RPPA) emphasizes mitochondria as targets for therapy	8
CCND3 is indispensable for the maintenance of B-cell acute lymphoblastic leukemia	8
TCF7L1 regulates cytokine response and neuroendocrine differentiation of prostate cancer	8
Anti-miR-135/SPOCK1 axis antagonizes the influence of metabolism on drug response in intestinal/colon tumour organoids	8
Moderate DNA hypomethylation suppresses intestinal tumorigenesis by promoting caspase-3 expression and apoptosis	8
NEDD9 sustains hexokinase expression to promote glycolysis	8
Circlehunter: a tool to identify extrachromosomal circular DNA from ATAC-Seq data	7
Engineered model of t(7;12)(q36;p13) AML recapitulates patient-specific features and gene expression profiles	7
Dysregulated G2 phase checkpoint recovery pathway reduces DNA repair efficiency and increases chromosomal instability in a wide range of tumours	7
CtBP1/2 differentially regulate genomic stability and DNA repair pathway in high-grade serous ovarian cancer cell	7
USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c	7
HLTF promotes hepatocellular carcinoma progression by enhancing SRSF1 stability and activating ERK/MAPK pathway	7
Non-enzymatic heparanase enhances gastric tumor proliferation via TFEB-dependent autophagy	7
The TIP60-ATM axis regulates replication fork stability in BRCA-deficient cells	6
miR-32 promotes MYC-driven prostate cancer	6
Vortioxetine hydrobromide inhibits the growth of gastric cancer cells in vivo and in vitro by targeting JAK2 and SRC	6
The SUMO protease SENP1 promotes aggressive behaviors of high HIF2α expressing renal cell carcinoma cells	6
Calreticulin enhances gastric cancer metastasis by dimethylating H3K9 in the E-cadherin promoter region mediating by G9a	6
Deep learning identifies a T-cell exhaustion-dependent transcriptional signature for predicting clinical outcomes and response to immune checkpoint blockade	6
A drug-repositioning screen using splicing-sensitive fluorescent reporters identifies novel modulators of VEGF-A splicing with anti-angiogenic properties	6