OOIR: Observatory of International Research

Papers

(The median citation count of Oncogenesis is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Gemcitabine as chemotherapy of head and neck cancer in Fanconi anemia patients	182
NUCKS1 promotes invasion and metastasis of colorectal cancer by stabilizing HDAC2 and activating AKT	120
Discovery of neddylation E2s inhibitors with therapeutic activity	113
Noncanonical PRC1.1 targets BTG2 to retain cyclin gene expression and cell growth in neuroblastoma	63
A HOTAIR-associated super-enhancer orchestrates glioblastoma malignancy via MEST	54
Vortioxetine hydrobromide inhibits the growth of gastric cancer cells in vivo and in vitro by targeting JAK2 and SRC	50
PELI1 and EGFR cooperate to promote breast cancer metastasis	49
Single-cell RNA sequencing reveals cell heterogeneity and transcriptome profile of breast cancer lymph node metastasis	48
USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c	42
Correction: Overexpression of SMC4 activates TGFβ/Smad signaling and promotes aggressive phenotype in glioma cells	41
ACTL6A suppresses p21Cip1 tumor suppressor expression to maintain an aggressive mesothelioma cancer cell phenotype	40
Targeted metabolomics detects a putatively diagnostic signature in plasma and dried blood spots from head and neck paraganglioma patients	38
P4HB maintains Wnt-dependent stemness in glioblastoma stem cells as a precision therapeutic target and serum marker	32
Biological differences underlying sex and gender disparities in bladder cancer: current synopsis and future directions	30
USP35 promotes cell proliferation and chemotherapeutic resistance through stabilizing FUCA1 in colorectal cancer	30
Correction: Mitochondrial dysfunction and impaired growth of glioblastoma cell lines caused by antimicrobial agents inducing ferroptosis under glucose starvation	30
PLEKHA4 is transcriptionally regulated by HOXD9 and regulates glycolytic reprogramming and progression in glioblastoma via activation of the STAT3/SOCS-1 pathway	30
A CRISPR knockout screen reveals new regulators of canonical Wnt signaling	29
Calreticulin enhances gastric cancer metastasis by dimethylating H3K9 in the E-cadherin promoter region mediating by G9a	29
Ablation of sphingosine kinase 2 suppresses fatty liver-associated hepatocellular carcinoma via downregulation of ceramide transfer protein	27
Post-transcriptional screen of cancer amplified genes identifies ERBB2/Her2 signaling as AU-rich mRNA stability-promoting pathway	25
Spindle function and Wnt pathway inhibition by PBX1 to suppress tumor progression via downregulating DCDC2 in colorectal cancer	25
Exosomes and cancer - Diagnostic and prognostic biomarkers and therapeutic vehicle	24
Involvement of the pro-oncogenic enzyme fatty acid synthase in the hallmarks of cancer: a promising target in anti-cancer therapies	24
UHRF1 overexpression promotes osteosarcoma metastasis through altered exosome production and AMPK/SEMA3E suppression	24

Breast cancer in the era of integrating “Omics” approaches	23
STAG2 expression imparts distinct therapeutic vulnerabilities in muscle-invasive bladder cancer cells	22
Preneoplastic cells switch to Warburg metabolism from their inception exposing multiple vulnerabilities for targeted elimination	22
FLT4 activation promotes acute lymphoid leukemia survival through stabilization of MDM2/MDMX and inactivation of p53	21
Collagen type IV alpha 6 promotes tumor progression and chemoresistance in ovarian cancer by activating the discoidin domain receptor 1 pathway	21
Coordinate transcriptional regulation of ErbB2/3 by C-terminal binding protein 2 signals sensitivity to ErbB2 inhibition in pancreatic adenocarcinoma	20
Diltiazem inhibits breast cancer metastasis via mediating growth differentiation factor 15 and epithelial-mesenchymal transition	20
CCND3 is indispensable for the maintenance of B-cell acute lymphoblastic leukemia	20
SLC26A3/NHERF2-IκB/NFκB/p65 feedback loop suppresses tumorigenesis and metastasis in colorectal cancer	19
PFKFB4 interacts with FBXO28 to promote HIF-1α signaling in glioblastoma	19
Correction: Heterogeneity of subsets in glioblastoma mediated by Smad3 palmitoylation	19
An E3 ligase TRIM1 promotes colorectal cancer progression via K63-linked ubiquitination and activation of HIF1α	19
Transgelin promotes lung cancer progression via activation of cancer-associated fibroblasts with enhanced IL-6 release	18
Involvement of Kindlin-1 in cutaneous squamous cell carcinoma	18
NAC1 transcriptional activation of LDHA induces hepatitis B virus immune evasion leading to cirrhosis and hepatocellular carcinoma development	18
GP73-mediated secretion of AFP and GP73 promotes proliferation and metastasis of hepatocellular carcinoma cells	18
Anti-PD-1 therapy achieves favorable outcomes in HBV-positive non-liver cancer	17
WDR5 facilitates recruitment of N-MYC to conserved WDR5 gene targets in neuroblastoma cell lines	17
Comprehensive multi-omics analysis of breast cancer reveals distinct long-term prognostic subtypes	17
Analysis of the metabolic proteome of lung adenocarcinomas by reverse-phase protein arrays (RPPA) emphasizes mitochondria as targets for therapy	16
Subtype-specific role for Jagged1 in promoting or inhibiting breast tumor formation	16
WDR4 promotes the progression and lymphatic metastasis of bladder cancer via transcriptional down-regulation of ARRB2	16
Generating in vitro models of NTRK-fusion mesenchymal neoplasia as tools for investigating kinase oncogenic activation and response to targeted therapy	16
TGF-β signaling redirects Sox11 gene regulatory activity to promote partial EMT and collective invasion of oncogenically transformed intestinal organoids	15
ACT001 inhibited CD133 transcription by targeting and inducing Olig2 ubiquitination degradation	15
HLTF promotes hepatocellular carcinoma progression by enhancing SRSF1 stability and activating ERK/MAPK pathway	15
Suppression of 4.1R enhances the potency of NKG2D-CAR T cells against pancreatic carcinoma via activating ERK signaling pathway	15
Correction: Non-enzymatic heparanase enhances gastric tumor proliferation via TFEB-dependent autophagy	14
Targeting macrophage migration inhibitory factor as a potential therapeutic strategy in colorectal cancer	14
LUBAC promotes angiogenesis and lung tumorigenesis by ubiquitinating and antagonizing autophagic degradation of HIF1α	14
Loss of MBD2 attenuates MLL-AF9-driven leukemogenesis by suppressing the leukemic cell cycle via CDKN1C	14
Correction: PBK phosphorylates MSL1 to elicit epigenetic modulation of CD276 in nasopharyngeal carcinoma	13
Correction: TRIM11 facilitates chemoresistance in nasopharyngeal carcinoma by activating the β-catenin/ABCC9 axis via p62-selective autophagic degradation of Daple	13
Correction: Tumor-derived exosomes induce PD1+ macrophage population in human gastric cancer that promotes disease progression	13
Aberrant APOBEC3C expression induces characteristic genomic instability in pancreatic ductal adenocarcinoma	13
Depletion of NK6 Homeobox 3 (NKX6.3) causes gastric carcinogenesis through copy number alterations by inducing impairment of DNA replication and repair regulation	13
Correction: Targeting IL-3Rα on tumor-derived endothelial cells blunts metastatic spread of triple-negative breast cancer via extracellular vesicle reprogramming	13
CD147-high extracellular vesicles promote gastric cancer metastasis via VEGF/AKT/eNOS and AKT/mTOR pathways	13
Co-activation of Sonic hedgehog and Wnt signaling in murine retinal precursor cells drives ocular lesions with features of intraocular medulloepithelioma	13
SIAH1 reverses chemoresistance in epithelial ovarian cancer via ubiquitination of YBX-1	12
Inactivation of the CIC-DUX4 oncogene through P300/CBP inhibition, a therapeutic approach for CIC-DUX4 sarcoma	12
Cdk5 drives formation of heterogeneous pancreatic neuroendocrine tumors	11
Identification of pancreatic cancer-specific protease substrates for protease-dependent targeted delivery	11
Retraction Note: A natural food sweetener with anti-pancreatic cancer properties	11
Targeting fucosyltransferase FUT8 as a prospective therapeutic approach for DLBCL	11
Fatty acid transport protein-5 (FATP5) deficiency enhances hepatocellular carcinoma progression and metastasis by reprogramming cellular energy metabolism and regulating the AMPK-mTOR signaling pathwa	11
The impact of neoadjuvant chemotherapy on the tumor microenvironment in advanced high-grade serous carcinoma	11
Progesterone receptor potentiates macropinocytosis through CDC42 in pancreatic ductal adenocarcinoma	11
The SWI/SNF ATPase BRG1 facilitates multiple pro-tumorigenic gene expression programs in SMARCB1-deficient cancer cells	10
The p52-ZER6/G6PD axis alters aerobic glycolysis and promotes tumor progression by activating the pentose phosphate pathway	10

Paladin, overexpressed in colon cancer, is required for actin polymerisation and liver metastasis dissemination	10
Negligible role of TRAIL death receptors in cell death upon endoplasmic reticulum stress in B-cell malignancies	10
Dual role of ANGPTL8 in promoting tumor cell proliferation and immune escape during hepatocarcinogenesis	10
Elevated ATGL in colon cancer cells and cancer stem cells promotes metabolic and tumorigenic reprogramming reinforced by obesity	10
TFCP2L1 drives stemness and enhances their resistance to Sorafenib treatment by modulating the NANOG/STAT3 pathway in hepatocellular carcinoma	10
Connexin 43 confers chemoresistance through activating PI3K	10
Transcriptomic analysis identifies B-lymphocyte kinase as a therapeutic target for desmoplastic small round cell tumor cancer stem cell-like cells	10
Correction to: Galectin-9 promotes a suppressive microenvironment in human cancer by enhancing STING degradation	10
Condensate remodeling reorganizes innate SS18 in synovial sarcomagenesis	10
A dominant SRCAP truncating mutation promotes squamous cell carcinoma progression	10
Proteomic meta-analysis unveils new frontiers for biomarkers research in pancreatic carcinoma	10
Methylation of HBP1 by PRMT1 promotes tumor progression by regulating actin cytoskeleton remodeling	10
Acidovorax temperans skews neutrophil maturation and polarizes Th17 cells to promote lung adenocarcinoma development	9
PSMC2 promotes the progression of gastric cancer via induction of RPS15A/mTOR pathway	9
Correction: FAM83B inhibits ovarian cancer cisplatin resistance through inhibiting Wnt pathway	9
Retraction Note: Platelet-derived growth factor receptor-α and -β promote cancer stem cell phenotypes in sarcomas	9
Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance	9
Tumor suppressor BAP1 suppresses disulfidptosis through the regulation of SLC7A11 and NADPH levels	9
CCT8 recovers WTp53-suppressed cell cycle evolution and EMT to promote colorectal cancer progression	8
CENPF (+) cancer cells promote malignant progression of early-stage TP53 mutant lung adenocarcinoma	8
Correction: USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c	8
miR-137–LAPTM4B regulates cytoskeleton organization and cancer metastasis via the RhoA-LIMK-Cofilin pathway in osteosarcoma	8
Androgen receptor variant 7 exacerbates hepatocarcinogenesis in a c-MYC-driven mouse HCC model	8
RIOK3 sustains colorectal cancer cell survival under glucose deprivation via an HSP90α-dependent pathway	8
CDK4/6 inhibitors and the pRB-E2F1 axis suppress PVR and PD-L1 expression in triple-negative breast cancer	8
LIN28B inhibition sensitizes cells to p53-restoring PPI therapy through unleashed translational suppression	8
Heterozygotic Brca1 mutation initiates mouse genome instability at embryonic stage	7
Designing patient-oriented combination therapies for acute myeloid leukemia based on efficacy/toxicity integration and bipartite network modeling	7
Correction: FIBP knockdown attenuates growth and enhances chemotherapy in colorectal cancer via regulating GSK3β-related pathways	7
Chasing non-existent “microRNAs” in cancer	7
Retinoic acid receptor β modulates mechanosensing and invasion in pancreatic cancer cells via myosin light chain 2	7
MYCN induces cell-specific tumorigenic growth in RB1-proficient human retinal organoid and chicken retina models of retinoblastoma	7
Heparanase modulates the prognosis and development of BRAF V600E-mutant colorectal cancer by regulating AKT/p27Kip1/Cyclin E2 pathway	7
IL-6 promotes drug resistance through formation of polyploid giant cancer cells and stromal fibroblast reprogramming	6
A MYC-ZNF148-ID1/3 regulatory axis modulating cancer stem cell traits in aggressive breast cancer	6
miR-32 promotes MYC-driven prostate cancer	6
Glucocorticoid receptor-induced non-muscle caldesmon regulates metastasis in castration-resistant prostate cancer	6
Inhibition of LDHB triggers DNA damage and increases cisplatin sensitivity in pleural mesothelioma	6
Targeting pregnane X receptor with a potent agonist-based PROTAC to delay colon cancer relapse	6
Evolution of HER2-positive mammary carcinoma: HER2 loss reveals claudin-low traits in cancer progression	6
ONC201 enhances the cytotoxic effect of cisplatin through ATF3/ATF4/CHOP in head and neck squamous cell carcinoma cells	6
Programmed cell death 11 modulates but not entirely relies on p53-HDM2 loop to facilitate G2/M transition in colorectal cancer cells	6
Exploring potential molecular resistance and clonal evolution in advanced HER2-positive gastric cancer under trastuzumab therapy	6
LPA receptor 1 (LPAR1) is a novel interaction partner of Filamin A that promotes Filamin A phosphorylation, MRTF-A transcriptional activity and oncogene-induced senescence	6
DDX3X interacts with SIRT7 to promote PD-L1 expression to facilitate PDAC progression	6