OOIR: Observatory of International Research

Papers

(The median citation count of Oncogenesis is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
MYB oncoproteins: emerging players and potential therapeutic targets in human cancer	75
CXCL5 promotes gastric cancer metastasis by inducing epithelial-mesenchymal transition and activating neutrophils	70
Understanding the common mechanisms of heart and skeletal muscle wasting in cancer cachexia	60
Single-cell RNA sequencing reveals cell heterogeneity and transcriptome profile of breast cancer lymph node metastasis	60
Long noncoding RNA TRPM2-AS acts as a microRNA sponge of miR-612 to promote gastric cancer progression and radioresistance	57
Exosomes and cancer - Diagnostic and prognostic biomarkers and therapeutic vehicle	56
BET protein inhibitor JQ1 downregulates chromatin accessibility and suppresses metastasis of gastric cancer via inactivating RUNX2/NID1 signaling	55
TRIM11 facilitates chemoresistance in nasopharyngeal carcinoma by activating the β-catenin/ABCC9 axis via p62-selective autophagic degradation of Daple	53
Hypoxia induces an endometrial cancer stem-like cell phenotype via HIF-dependent demethylation of SOX2 mRNA	51
Galectin-9 promotes a suppressive microenvironment in human cancer by enhancing STING degradation	51
Exploring and modelling colon cancer inter-tumour heterogeneity: opportunities and challenges	48
Targeting PD-L1 in non-small cell lung cancer using CAR T cells	48
Metformin exhibits antiproliferation activity in breast cancer via miR-483-3p/METTL3/m6A/p21 pathway	48
TGF-β1-mediated transition of resident fibroblasts to cancer-associated fibroblasts promotes cancer metastasis in gastrointestinal stromal tumor	47
miR-18a promotes glioblastoma development by down-regulating ALOXE3-mediated ferroptotic and anti-migration activities	46
ACSL4 promotes hepatocellular carcinoma progression via c-Myc stability mediated by ERK/FBW7/c-Myc axis	43
Suppressing DRP1-mediated mitochondrial fission and mitophagy increases mitochondrial apoptosis of hepatocellular carcinoma cells in the setting of hypoxia	42
Tumor-derived HMGB1 induces CD62Ldim neutrophil polarization and promotes lung metastasis in triple-negative breast cancer	41
Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance	38
COX6B2 drives metabolic reprogramming toward oxidative phosphorylation to promote metastasis in pancreatic ductal cancer cells	38
LONP1 and ClpP cooperatively regulate mitochondrial proteostasis for cancer cell survival	37
PI3K/Akt pathway and Nanog maintain cancer stem cells in sarcomas	37
lncRNA-SOX2OT promotes hepatocellular carcinoma invasion and metastasis through miR-122-5p-mediated activation of PKM2	36
Triptolide targets super-enhancer networks in pancreatic cancer cells and cancer-associated fibroblasts	36
Overexpression of Cyclin E1 or Cdc25A leads to replication stress, mitotic aberrancies, and increased sensitivity to replication checkpoint inhibitors	35

YAP/TAZ inhibition reduces metastatic potential of Ewing sarcoma cells	31
USP29-mediated HIF1α stabilization is associated with Sorafenib resistance of hepatocellular carcinoma cells by upregulating glycolysis	30
Regulation of invasion and peritoneal dissemination of ovarian cancer by mesothelin manipulation	30
Targeting IL-3Rα on tumor-derived endothelial cells blunts metastatic spread of triple-negative breast cancer via extracellular vesicle reprogramming	30
IL-6 promotes drug resistance through formation of polyploid giant cancer cells and stromal fibroblast reprogramming	28
Desmoplastic small round cell tumor is dependent on the EWS-WT1 transcription factor	28
Diethyldithiocarbamate-copper complex (CuET) inhibits colorectal cancer progression via miR-16-5p and 15b-5p/ALDH1A3/PKM2 axis-mediated aerobic glycolysis pathway	28
MeCP2 facilitates breast cancer growth via promoting ubiquitination-mediated P53 degradation by inhibiting RPL5/RPL11 transcription	27
The long non-coding RNA PIK3CD-AS2 promotes lung adenocarcinoma progression via YBX1-mediated suppression of p53 pathway	25
Regulation of Hippo signaling and triple negative breast cancer progression by an ubiquitin ligase RNF187	25
OXER1 and RACK1-associated pathway: a promising drug target for breast cancer progression	25
Feedback activation of STAT3 limits the response to PI3K/AKT/mTOR inhibitors in PTEN-deficient cancer cells	25
Dissecting the single-cell transcriptome network in patients with esophageal squamous cell carcinoma receiving operative paclitaxel plus platinum chemotherapy	24
PRMT1 promotes neuroblastoma cell survival through ATF5	24
Epigenetic regulation of TGF-β-induced EMT by JMJD3/KDM6B histone H3K27 demethylase	24
LIMK2 promotes the metastatic progression of triple-negative breast cancer by activating SRPK1	24
Surface charge of Merkel cell polyomavirus small T antigen determines cell transformation through allosteric FBW7 WD40 domain targeting	23
microRNA-199a-3p inhibits hepatic apoptosis and hepatocarcinogenesis by targeting PDCD4	23
Emerging role of SWI/SNF complex deficiency as a target of immune checkpoint blockade in human cancers	23
SOX9 interacts with FOXC1 to activate MYC and regulate CDK7 inhibitor sensitivity in triple-negative breast cancer	23
Angiogenesis and immune checkpoint dual blockade in combination with radiotherapy for treatment of solid cancers: opportunities and challenges	23
Antileukemic activity of the VPS34-IN1 inhibitor in acute myeloid leukemia	23
Tumor-secreted exosomal Wnt2B activates fibroblasts to promote cervical cancer progression	22
Functional screening identifies aryl hydrocarbon receptor as suppressor of lung cancer metastasis	22
Breast cancer in the era of integrating “Omics” approaches	22
EHF suppresses cancer progression by inhibiting ETS1-mediated ZEB expression	22
Squalene synthase promotes the invasion of lung cancer cells via the osteopontin/ERK pathway	22
MiR-22, regulated by MeCP2, suppresses gastric cancer cell proliferation by inducing a deficiency in endogenous S-adenosylmethionine	21
Cell-type-specific role of CHK2 in mediating DNA damage-induced G2 cell cycle arrest	20
Aberrant super-enhancer landscape reveals core transcriptional regulatory circuitry in lung adenocarcinoma	20
TAp63α targeting of Lgr5 mediates colorectal cancer stem cell properties and sulforaphane inhibition	20
Tumour heterogeneity and evolutionary dynamics in colorectal cancer	20
Cyclin D1 targets hexokinase 2 to control aerobic glycolysis in myeloma cells	20
TRPC1 promotes the genesis and progression of colorectal cancer via activating CaM-mediated PI3K/AKT signaling axis	19
Hypoxia promotes an inflammatory phenotype of fibroblasts in pancreatic cancer	19
Loss of HAT1 expression confers BRAFV600E inhibitor resistance to melanoma cells by activating MAPK signaling via IGF1R	19
CXCL12/CXCR4 axis supports mitochondrial trafficking in tumor myeloma microenvironment	19
USP38 regulates the stemness and chemoresistance of human colorectal cancer via regulation of HDAC3	19
Elevated ATGL in colon cancer cells and cancer stem cells promotes metabolic and tumorigenic reprogramming reinforced by obesity	19
Neutrophils and polymorphonuclear myeloid-derived suppressor cells: an emerging battleground in cancer therapy	18
Inactivation of the CIC-DUX4 oncogene through P300/CBP inhibition, a therapeutic approach for CIC-DUX4 sarcoma	18
Emerging role of G9a in cancer stemness and promises as a therapeutic target	18
PBK phosphorylates MSL1 to elicit epigenetic modulation of CD276 in nasopharyngeal carcinoma	18
RETRACTED ARTICLE: Acetyl-CoA synthetase 3 promotes bladder cancer cell growth under metabolic stress	18
BRN2 expression increases anoikis resistance in melanoma	18
PNO1, which is negatively regulated by miR-340-5p, promotes lung adenocarcinoma progression through Notch signaling pathway	18
GLIS2 promotes colorectal cancer through repressing enhancer activation	18
Carbidopa suppresses prostate cancer via aryl hydrocarbon receptor-mediated ubiquitination and degradation of androgen receptor	17
E2F1 and epigenetic modifiers orchestrate breast cancer progression by regulating oxygen-dependent ESRP1 expression	17
PRMT6 activates cyclin D1 expression in conjunction with the transcription factor LEF1	17

Inhibition of Bruton’s tyrosine kinase as a therapeutic strategy for chemoresistant oral squamous cell carcinoma and potential suppression of cancer stemness	17
Inhibition of Chk1 by miR-320c increases oxaliplatin responsiveness in triple-negative breast cancer	16
Transcription co-activator P300 activates Elk1-aPKC-ι signaling mediated epithelial-to-mesenchymal transition and malignancy in hepatocellular carcinoma	16
Tumour cells express functional lymphatic endothelium-specific hyaluronan receptor in vitro and in vivo: Lymphatic mimicry promotes oral oncogenesis?	16
Musashi-2 (MSI2) regulates epidermal growth factor receptor (EGFR) expression and response to EGFR inhibitors in EGFR-mutated non-small cell lung cancer (NSCLC)	16
MiR-93 is related to poor prognosis in pancreatic cancer and promotes tumor progression by targeting microtubule dynamics	15
USP42 enhances homologous recombination repair by promoting R-loop resolution with a DNA–RNA helicase DHX9	15
A novel dual HDAC and HSP90 inhibitor, MPT0G449, downregulates oncogenic pathways in human acute leukemia in vitro and in vivo	15
NNMT promotes the progression of intrahepatic cholangiocarcinoma by regulating aerobic glycolysis via the EGFR-STAT3 axis	15
AUF1 promotes stemness in human mammary epithelial cells through stabilization of the EMT transcription factors TWIST1 and SNAIL1	15
EZH2 facilitates BMI1-dependent hepatocarcinogenesis through epigenetically silencing microRNA-200c	15
The membrane-associated form of cyclin D1 enhances cellular invasion	15
TGFβ/cyclin D1/Smad-mediated inhibition of BMP4 promotes breast cancer stem cell self-renewal activity	14
Non-metabolic role of UCK2 links EGFR-AKT pathway activation to metastasis enhancement in hepatocellular carcinoma	14
Resistance to BET inhibitors in lung adenocarcinoma is mediated by casein kinase phosphorylation of BRD4	14
Heterogeneity of subsets in glioblastoma mediated by Smad3 palmitoylation	14
CCT8 recovers WTp53-suppressed cell cycle evolution and EMT to promote colorectal cancer progression	14
A novel β2-AR/YB-1/β-catenin axis mediates chronic stress-associated metastasis in hepatocellular carcinoma	14
SIAH1 reverses chemoresistance in epithelial ovarian cancer via ubiquitination of YBX-1	14
Profiling of subcellular EGFR interactome reveals hnRNP A3 modulates nuclear EGFR localization	13
Evolution of HER2-positive mammary carcinoma: HER2 loss reveals claudin-low traits in cancer progression	13
Epigenetic activation of the small GTPase TCL contributes to colorectal cancer cell migration and invasion	13
Fusion protein-driven IGF-IR/PI3K/AKT signals deregulate Hippo pathway promoting oncogenic cooperation of YAP1 and FUS-DDIT3 in myxoid liposarcoma	13
Prolactin receptor-driven combined luminal and epithelial differentiation in breast cancer restricts plasticity, stemness, tumorigenesis and metastasis	13
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) with OT-82 induces DNA damage, cell death, and suppression of tumor growth in preclinical models of Ewing sarcoma	13
Loss of p53 suppresses replication stress-induced DNA damage in ATRX-deficient neuroblastoma	13
Methyl-CpG-binding protein 2 drives the Furin/TGF-β1/Smad axis to promote epithelial–mesenchymal transition in pancreatic cancer cells	13
Notch3 contributes to T-cell leukemia growth via regulation of the unfolded protein response	13
The functional analysis of Cullin 7 E3 ubiquitin ligases in cancer	13
Precision modeling of gall bladder cancer patients in mice based on orthotopic implantation of organoid-derived tumor buds	12
The mechanical phenotypic plasticity of melanoma cell: an emerging driver of therapy cross-resistance	12
Breast tumor cells promotes the horizontal propagation of EMT, stemness, and metastasis by transferring the MAP17 protein between subsets of neoplastic cells	12
Fatty acid transport protein-5 (FATP5) deficiency enhances hepatocellular carcinoma progression and metastasis by reprogramming cellular energy metabolism and regulating the AMPK-mTOR signaling pathwa	12
PSMC2 promotes the progression of gastric cancer via induction of RPS15A/mTOR pathway	12
Nuclear FOXP3 inhibits tumor growth and induced apoptosis in hepatocellular carcinoma by targeting c-Myc	12
USP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer	12
The E3 ubiquitin ligase MG53 inhibits hepatocellular carcinoma by targeting RAC1 signaling	12
New preclinical models for angioimmunoblastic T-cell lymphoma: filling the GAP	12
Connexin 43 confers chemoresistance through activating PI3K	11
C20orf204, a hepatocellular carcinoma-specific protein interacts with nucleolin and promotes cell proliferation	11
Disruption of STAT5A and NMI signaling axis leads to ISG20-driven metastatic mammary tumors	11
Kras activation in endometrial organoids drives cellular transformation and epithelial-mesenchymal transition	11
Estradiol-mediated inhibition of DNMT1 decreases p53 expression to induce M2-macrophage polarization in lung cancer progression	11
YWHAE-NUTM2 oncoprotein regulates proliferation and cyclin D1 via RAF/MAPK and Hippo pathways	11
MMP8 increases tongue carcinoma cell–cell adhesion and diminishes migration via cleavage of anti-adhesive FXYD5	11
Nuclear factor IX promotes glioblastoma development through transcriptional activation of Ezrin	10
WAVE3 phosphorylation regulates the interplay between PI3K, TGF-β, and EGF signaling pathways in breast cancer	10
The prohibitin-binding compound fluorizoline inhibits mitophagy in cancer cells	10
FAM83B inhibits ovarian cancer cisplatin resistance through inhibiting Wnt pathway	10
CARD10 cleavage by MALT1 restricts lung carcinoma growth in vivo	10
Sulfated alginate oligosaccharide exerts antitumor activity and autophagy induction by inactivating MEK1/ERK/mTOR signaling in a KSR1-dependent manner in osteosarcoma	10
Cdk5 drives formation of heterogeneous pancreatic neuroendocrine tumors	10
Tripartite motif-containing 3 (TRIM3) enhances ER signaling and confers tamoxifen resistance in breast cancer	9
Disruptor of telomeric silencing 1-like promotes ovarian cancer tumor growth by stimulating pro-tumorigenic metabolic pathways and blocking apoptosis	9
Overexpression of glycosyltransferase 8 domain containing 2 confers ovarian cancer to CDDP resistance by activating FGFR/PI3K signalling axis	9
High expression of PSMC2 promotes gallbladder cancer through regulation of GNG4 and predicts poor prognosis	9
Tumour suppressor 15-hydroxyprostaglandin dehydrogenase induces differentiation in colon cancer via GLI1 inhibition	9
UHRF1 overexpression promotes osteosarcoma metastasis through altered exosome production and AMPK/SEMA3E suppression	9
RNF8 ubiquitinates RecQL4 and promotes its dissociation from DNA double strand breaks	9
The metastasis suppressor protein NM23-H1 modulates the PI3K-AKT axis through interaction with the p110α catalytic subunit	9
Single-cell RNA sequencing reveals that targeting HSP90 suppresses PDAC progression by restraining mitochondrial bioenergetics	9
Involvement of the pro-oncogenic enzyme fatty acid synthase in the hallmarks of cancer: a promising target in anti-cancer therapies	9
PLEKHA5 regulates the survival and peritoneal dissemination of diffuse-type gastric carcinoma cells with Met gene amplification	9
Reduction of SCUBE3 by a new marine-derived asterosaponin leads to arrest of glioma cells in G1/S	9
The identification of nuclear αvβ3 integrin in ovarian cancer: non-paradigmal localization with cancer promoting actions	9
Enhanced DNA-repair capacity and resistance to chemically induced carcinogenesis upon deletion of the phosphatase regulator NIPP1	8
GP73-mediated secretion of AFP and GP73 promotes proliferation and metastasis of hepatocellular carcinoma cells	8
Ablation of sphingosine kinase 2 suppresses fatty liver-associated hepatocellular carcinoma via downregulation of ceramide transfer protein	8
Clathrin adapters AP-1 and GGA2 support expression of epidermal growth factor receptor for cell growth	8
GSK3β palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2–STAT3 axis	8
Methylation of HBP1 by PRMT1 promotes tumor progression by regulating actin cytoskeleton remodeling	8
Cdc37 suppression induces plasma cell immaturation and bortezomib resistance in multiple myeloma via Xbp1s	8
Tumor suppressor p53 restrains cancer cell dissemination by modulating mitochondrial dynamics	8
Ovarian BDNF promotes survival, migration, and attachment of tumor precursors originated from p53 mutant fallopian tube epithelial cells	8
MicroRNA-21 is immunosuppressive and pro-metastatic via separate mechanisms	8
Aberrant APOBEC3C expression induces characteristic genomic instability in pancreatic ductal adenocarcinoma	8