Nature Biomedical Engineering

Article	Citations
Base editing ablates all protein-coding genes of the mitochondrial genome in mouse cells	876
Arming T cells to infiltrate pancreatic tumours	790
Sutures for the wireless sensing of deep wounds	692
Efficient circular RNA synthesis for potent rolling circle translation	396
A base editor for correcting deafness	395
Author Correction: Enhanced control of a brain–computer interface by tetraplegic participants via neural-network-mediated feature extraction	374
A soft robotic sleeve mimicking the haemodynamics and biomechanics of left ventricular pressure overload and aortic stenosis	303
Robust and data-efficient generalization of self-supervised machine learning for diagnostic imaging	286
Rapid and stain-free quantification of viral plaque via lens-free holography and deep learning	285
Induction of antigen-specific tolerance by nanobody–antigen adducts that target class-II major histocompatibility complexes	258
Lasso-grafted designer cytokines	244
Rational vaccinology maximizes the efficacy of multi-antigen vaccines	222
Fast volumetric scanning of living tissue	219
Erythrocyte-mediated systemic immunotherapy	217
Textile-embedded cell-free biosensors	215
An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma	204
MRI of transmembrane water efflux in gliomas	204
Derivation of prognostic contextual histopathological features from whole-slide images of tumours via graph deep learning	201
An engineered live biotherapeutic for the prevention of antibiotic-induced dysbiosis	200
A lentiviral vector for the production of T cells with an inducible transgene and a constitutively expressed tumour-targeting receptor	195
Prevention of vascular-allograft rejection by protecting the endothelial glycocalyx with immunosuppressive polymers	193
Generation of synthetic whole-slide image tiles of tumours from RNA-sequencing data via cascaded diffusion models	182
A window into solid stresses within tumours	173
Glycation-driven matrix crosslinking in cirrhosis	170
Affordable hearing screening	166

Oxonium ion scanning mass spectrometry for large-scale plasma glycoproteomics	166
Affinity maturation of CRISPR-engineered B cell receptors in vivo	160
The myriad ways to engineer cells	159
Engineering cell-derived extracellular vesicles for gene therapy	158
Intravascularly infused extracellular matrix as a biomaterial for targeting and treating inflamed tissues	150
Retinal detection of kidney disease and diabetes	149
Tooling up against mechanobiological orthodoxy	143
Hail the AI journal editor	141
Write accessibly	141
Sealing the heart from the inside out	140
How to appeal well	133
Potentiating cancer immunotherapies	132
Pathological mechanosensing	129
An instrument-free, programmable approach for nucleic acid detection	128
Contactless optical coherence tomography of the eyes of freestanding individuals with a robotic scanner	127
Non-invasive monitoring of autophagy	127
Deep mutational scanning and machine learning for the analysis of antimicrobial-peptide features driving membrane selectivity	126
Multiplexed transcriptomic profiling of the fate of human CAR T cells in vivo via genetic barcoding with shielded small nucleotides	126
Efficient production of non-immunogenic, long circular RNAs for high protein yield	123
PEGylated bacteria penetrate mucus and strengthen the gut mucosal barrier	123
Leucine zipper-based immunomagnetic purification of CAR T cells displaying multiple receptors	122
Wireless and battery-free technologies for neuroengineering	119
Publisher Correction: Targeting overexpressed antigens in glioblastoma via CAR T cells with computationally designed high-affinity protein binders	118
Computational design of protein binders that boost the antitumour efficacy of CAR T cells	118
Evolving virus-like particles	113
Enhancement of erythropoietic output by Cas9-mediated insertion of a natural variant in haematopoietic stem and progenitor cells	112
A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics	111
Prediction of the cell-type-specific transcription of non-coding RNAs from genome sequences via machine learning	111
The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans	111
‘Hit and run’ therapy averts macular degeneration	110
A humanized minipig model for the toxicological testing of therapeutic recombinant antibodies	110
A library of base editors for the precise ablation of all protein-coding genes in the mouse mitochondrial genome	110
A soft and transparent contact lens for the wireless quantitative monitoring of intraocular pressure	108
Generation of neural organoids for spinal-cord regeneration via the direct reprogramming of human astrocytes	108
Sensitive detection of SARS-CoV-2 on paper	104
Brachytherapy via a depot of biopolymer-bound 131I synergizes with nanoparticle paclitaxel in therapy-resistant pancreatic tumours	103
Assessment of visual function in blind mice and monkeys with subretinally implanted nanowire arrays as artificial photoreceptors	101
Detection of cellular traction forces via the force-triggered Cas12a-mediated catalytic cleavage of a fluorogenic reporter strand	100
Field validation of the performance of paper-based tests for the detection of the Zika and chikungunya viruses in serum samples	100
Exosome-eluting stents for vascular healing after ischaemic injury	99
A deep-learning model for transforming the style of tissue images from cryosectioned to formalin-fixed and paraffin-embedded	99
Systemic immune responses to irradiated tumours via the transport of antigens to the tumour periphery by injected flagellate bacteria	97
Stable expression of large transgenes via the knock-in of an integrase-deficient lentivirus	97
A strain-programmed patch for the healing of diabetic wounds	93
Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance	92
Enhanced engraftment of human haematopoietic stem cells via mechanical remodelling mediated by the corticotropin-releasing hormone	92
Solid stress impairs lymphocyte infiltration into lymph-node metastases	92
Posterior scleral birefringence measured by triple-input polarization-sensitive imaging as a biomarker of myopia progression	91
Neutrophils bearing adhesive polymer micropatches as a drug-free cancer immunotherapy	91
Mesenchymal stromal cells with chimaeric antigen receptors for enhanced immunosuppression	90

Miniaturized implantable temperature sensors for the long-term monitoring of chronic intestinal inflammation	90
A lab-on-a-chip for the concurrent electrochemical detection of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in saliva and plasma	89
Variants of the adeno-associated virus serotype 9 with enhanced penetration of the blood–brain barrier in rodents and primates	88
Characterization of the responses of brain macrophages to focused ultrasound-mediated blood–brain barrier opening	88
Generation of hypoimmunogenic T cells from genetically engineered allogeneic human induced pluripotent stem cells	87
Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine	87
Shear-stress sensing by PIEZO1 regulates tendon stiffness in rodents and influences jumping performance in humans	84
Deep brain stimulation by blood–brain-barrier-crossing piezoelectric nanoparticles generating current and nitric oxide under focused ultrasound	84
Soft and stretchable organic bioelectronics for continuous intraoperative neurophysiological monitoring during microsurgery	80
Profiling of repetitive RNA sequences in the blood plasma of patients with cancer	80
Identification of potent antimicrobial peptides via a machine-learning pipeline that mines the entire space of peptide sequences	80
A nanoparticle probe for the imaging of autophagic flux in live mice via magnetic resonance and near-infrared fluorescence	78
Antigen-bearing outer membrane vesicles as tumour vaccines produced in situ by ingested genetically engineered bacteria	78
Massively parallel functional photoacoustic computed tomography of the human brain	77
Compact brain MRI	77
Meta-analysis of the make-up and properties of in vitro models of the healthy and diseased blood–brain barrier	75
Surgical polarimetric endoscopy for the detection of laryngeal cancer	75
Heterogeneity-driven phenotypic plasticity and treatment response in branched-organoid models of pancreatic ductal adenocarcinoma	73
Author Correction: Ultrasensitive detection of circulating tumour DNA via deep methylation sequencing aided by machine learning	72
Setting morphogen gradients	72
Publisher Correction: Compression and amplification algorithms in hearing aids impair the selectivity of neural responses to speech	72
Antitumour vaccination via the targeted proteolysis of antigens isolated from tumour lysates	72
Author Correction: Prolonged activation of innate immune pathways by a polyvalent STING agonist	71
Author Correction: An organoid-based screen for epigenetic inhibitors that stimulate antigen presentation and potentiate T-cell-mediated cytotoxicity	71
Author Correction: Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation	70
Author Correction: Blood–brain barrier injury and neuroinflammation induced by SARS-CoV-2 in a lung–brain microphysiological system	70
Author Correction: A low-power stretchable neuromorphic nerve with proprioceptive feedback	69
High-throughput screening of genetic and cellular drivers of syncytium formation induced by the spike protein of SARS-CoV-2	68
Metabolic and immunomodulatory control of type 1 diabetes via orally delivered bile-acid-polymer nanocarriers of insulin or rapamycin	68
Author Correction: Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans	68
Screening for CD19-specific chimaeric antigen receptors with enhanced signalling via a barcoded library of intracellular domains	65
An epidermal patch for the simultaneous monitoring of haemodynamic and metabolic biomarkers	64
Detection of signs of disease in external photographs of the eyes via deep learning	63
Enhanced control of a brain–computer interface by tetraplegic participants via neural-network-mediated feature extraction	62
Rejuvenation of tumour-specific T cells through bispecific antibodies targeting PD-L1 on dendritic cells	61
Bone mineral slows down breast cancer cells	59
Equitable hiring strategies towards a diversified faculty	59
Blood–wall fluttering instability as a physiomarker of the progression of thoracic aortic aneurysms	59
In-ear integrated sensor array for the continuous monitoring of brain activity and of lactate in sweat	59
How to make cover letters instructive	58
Single-cell analysis of ductal differentiation	57
Designing stable humanized antibodies	57
Sutureless gastrointestinal anastomoses	56
Electric boost of MRI contrast for epileptic foci	55
DNA-based computation for multiple biomarkers	54
A highly sensitive and robust one-pot assay for the detection of microRNAs	54
Conditional immortalization of human atrial myocytes for the generation of in vitro models of atrial fibrillation	52
Multiple-instance learning of somatic mutations for the classification of tumour type and the prediction of microsatellite status	51
Optimization of Cas9 activity through the addition of cytosine extensions to single-guide RNAs	51
Towards handy neural prostheses	50
Ever easier health monitoring	50
Using extracellular vesicles in blood to diagnose paediatric tuberculosis	50
Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity	49
Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning	49
Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage	48
Wirelessly operated bioelectronic sutures for the monitoring of deep surgical wounds	47
A high-density microfluidic bioreactor for the automated manufacturing of CAR T cells	47
Bacterial couriers as cancer vaccines	47
FAS-less allogeneic CAR T cells	47
Downregulating human leucocyte antigens on mesenchymal stromal cells by epigenetically repressing a β2-microglobulin super-enhancer	46
Synthetic multimodal data modelling for data imputation	46
A one-pot isothermal Cas12-based assay for the sensitive detection of microRNAs	45
Deep profiling of gene expression across 18 human cancers	45
Localization of protoporphyrin IX during glioma-resection surgery via paired stimulated Raman histology and fluorescence microscopy	44
Lipid nanoparticles for the inhalation of mRNA	44
Site-specific PEGylation of interleukin-2 enhances immunosuppression via the sustained activation of regulatory T cells	44
Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity	44
A miniaturized mesoscope for the large-scale single-neuron-resolved imaging of neuronal activity in freely behaving mice	44
Highly multiplexed rapid DNA detection with single-nucleotide specificity via convective PCR in a portable device	44
Chemomechanically antifibrotic stromal cells	43
Streamlining point-of-care assays	42
A one-photon endoscope for simultaneous patterned optogenetic stimulation and calcium imaging in freely behaving mice	42
A hydrogel-entrapped live virus immunization	42
Multimodal evidence suggests the linearity of brain dynamics at the macroscale	42
How we decline manuscripts	42
Collagen-binding peptides for the enhanced imaging, lubrication and regeneration of osteoarthritic articular cartilage	42
Identification of druggable regulators of cell secretion via a kinome-wide screen and high-throughput immunomagnetic cell sorting	41
Transmembrane water-efflux rate measured by magnetic resonance imaging as a biomarker of the expression of aquaporin-4 in gliomas	40
A biomaterial infused into the bloodstream repairs inflamed tissue	40
Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy	40

Extensively edited pigs	40
Adaptive adversarial neural networks for the analysis of lossy and domain-shifted datasets of medical images	39
Transcranial ultrafast ultrasound localization microscopy of brain vasculature in patients	39
Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles	39
Treatment of peanut allergy and colitis in mice via the intestinal release of butyrate from polymeric micelles	38
Extracellular vesicles incorporating retrovirus-like capsids for the enhanced packaging and systemic delivery of mRNA into neurons	38
Fluorescence lifetime of injected indocyanine green as a universal marker of solid tumours in patients	38
Techniques for supercharging academic writing with generative AI	37
Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington’s disease	37
Moving beyond single-electrode intracortical-microstimulation-evoked tactile perception	36
Patterned gastrointestinal monolayers with bilateral access as observable models of parasite gut infection	36
Continuous monitoring of deep-tissue haemodynamics with stretchable ultrasonic phased arrays	35
T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours	35
Enhanced DNA libraries for methylation analysis	35
Nutritional deficiency in an intestine-on-a-chip recapitulates injury hallmarks associated with environmental enteric dysfunction	35
What’s really new in this work?	35