Nature Biomedical Engineering

(The TQCC of Nature Biomedical Engineering is 44. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)
The evolution of commercial drug delivery technologies550
Data-efficient and weakly supervised computational pathology on whole-slide images541
CRISPR-based diagnostics495
Clinical validation of a Cas13-based assay for the detection of SARS-CoV-2 RNA432
An epidermal patch for the simultaneous monitoring of haemodynamic and metabolic biomarkers313
Pre-symptomatic detection of COVID-19 from smartwatch data296
Synthetic data in machine learning for medicine and healthcare250
A wearable electrochemical biosensor for the monitoring of metabolites and nutrients244
Rapid single-molecule detection of COVID-19 and MERS antigens via nanobody-functionalized organic electrochemical transistors235
High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays225
Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity223
A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics219
Integrating spatial gene expression and breast tumour morphology via deep learning194
Rapid lateral flow immunoassay for the fluorescence detection of SARS-CoV-2 RNA193
An integrated wearable microneedle array for the continuous monitoring of multiple biomarkers in interstitial fluid181
Microneedle patch for the ultrasensitive quantification of protein biomarkers in interstitial fluid177
Catheter-integrated soft multilayer electronic arrays for multiplexed sensing and actuation during cardiac surgery176
Tumour sensitization via the extended intratumoural release of a STING agonist and camptothecin from a self-assembled hydrogel167
A soft neuroprosthetic hand providing simultaneous myoelectric control and tactile feedback167
Optimization of lipid nanoparticles for the delivery of nebulized therapeutic mRNA to the lungs165
Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets162
A multi-organ chip with matured tissue niches linked by vascular flow161
Treatment of infarcted heart tissue via the capture and local delivery of circulating exosomes through antibody-conjugated magnetic nanoparticles160
Fast detection of SARS-CoV-2 RNA via the integration of plasmonic thermocycling and fluorescence detection in a portable device159
Rapid and ultrasensitive electromechanical detection of ions, biomolecules and SARS-CoV-2 RNA in unamplified samples159
Prolonged activation of innate immune pathways by a polyvalent STING agonist158
Accelerated antimicrobial discovery via deep generative models and molecular dynamics simulations156
Transcranial ultrafast ultrasound localization microscopy of brain vasculature in patients156
Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning154
Rapid and coagulation-independent haemostatic sealing by a paste inspired by barnacle glue149
Enhanced tumour penetration and prolonged circulation in blood of polyzwitterion–drug conjugates with cell-membrane affinity148
Collagen-binding IL-12 enhances tumour inflammation and drives the complete remission of established immunologically cold mouse tumours141
Wireless and battery-free technologies for neuroengineering139
Sensitive fluorescence detection of SARS-CoV-2 RNA in clinical samples via one-pot isothermal ligation and transcription131
A deep-learning system for the assessment of cardiovascular disease risk via the measurement of retinal-vessel calibre130
Intravital three-dimensional bioprinting127
The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans124
Deep-learning models for the detection and incidence prediction of chronic kidney disease and type 2 diabetes from retinal fundus images123
Stabilization of a brain–computer interface via the alignment of low-dimensional spaces of neural activity119
Open resource of clinical data from patients with pneumonia for the prediction of COVID-19 outcomes via deep learning116
A mountable toilet system for personalized health monitoring via the analysis of excreta112
Prospective assessment of breast cancer risk from multimodal multiview ultrasound images via clinically applicable deep learning112
A lab-on-a-chip for the concurrent electrochemical detection of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in saliva and plasma112
Self-supervised learning in medicine and healthcare112
Fast and sensitive detection of SARS-CoV-2 RNA using suboptimal protospacer adjacent motifs for Cas12a110
Ultrabright fluorescent nanoscale labels for the femtomolar detection of analytes with standard bioassays109
Extensive germline genome engineering in pigs108
Ultrasensitive high-resolution profiling of early seroconversion in patients with COVID-19108
Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow107
Restoration of sensory information via bionic hands107
Transdermal microneedles for the programmable burst release of multiple vaccine payloads105
Continuous monitoring of deep-tissue haemodynamics with stretchable ultrasonic phased arrays104
Toward higher-performance bionic limbs for wider clinical use103
Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine102
A deep-learning pipeline for the diagnosis and discrimination of viral, non-viral and COVID-19 pneumonia from chest X-ray images102
Identification of psychiatric disorder subtypes from functional connectivity patterns in resting-state electroencephalography102
A portable scanner for magnetic resonance imaging of the brain101
Enhancement of the blood-circulation time and performance of nanomedicines via the forced clearance of erythrocytes100
A soft and transparent contact lens for the wireless quantitative monitoring of intraocular pressure100
Cryomicroneedles for transdermal cell delivery99
Stimulation of neural stem cell differentiation by circularly polarized light transduced by chiral nanoassemblies98
Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance98
Combination of tumour-infarction therapy and chemotherapy via the co-delivery of doxorubicin and thrombin encapsulated in tumour-targeted nanoparticles98
Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel94
Lentiviral delivery of co-packaged Cas9 mRNA and a Vegfa-targeting guide RNA prevents wet age-related macular degeneration in mice94
Design and clinical implementation of an open-source bionic leg94
Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy93
Neutralizing antibodies for the treatment of COVID-1993
Burst release of encapsulated annexin A5 in tumours boosts cytotoxic T-cell responses by blocking the phagocytosis of apoptotic cells93
Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity93
Massively parallel functional photoacoustic computed tomography of the human brain93
Exosome-eluting stents for vascular healing after ischaemic injury92
Methotrexate-loaded tumour-cell-derived microvesicles can relieve biliary obstruction in patients with extrahepatic cholangiocarcinoma91
An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma91
Rapid manufacturing of non-activated potent CAR T cells90
Injectable and conductive cardiac patches repair infarcted myocardium in rats and minipigs90
Modelling and prediction of the dynamic responses of large-scale brain networks during direct electrical stimulation88
A paper-based assay for the colorimetric detection of SARS-CoV-2 variants at single-nucleotide resolution87
A fidget spinner for the point-of-care diagnosis of urinary tract infection87
Generation of model tissues with dendritic vascular networks via sacrificial laser-sintered carbohydrate templates87
Application of prime editing to the correction of mutations and phenotypes in adult mice with liver and eye diseases86
Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing86
Control of the activity of CAR-T cells within tumours via focused ultrasound84
A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves84
Classification of T-cell activation via autofluorescence lifetime imaging84
AND-gate contrast agents for enhanced fluorescence-guided surgery83
Tether-free photothermal deep-brain stimulation in freely behaving mice via wide-field illumination in the near-infrared-II window83
Fungal brain infection modelled in a human-neurovascular-unit-on-a-chip with a functional blood–brain barrier83
A web tool for the design of prime-editing guide RNAs83
A strain-programmed patch for the healing of diabetic wounds83
Discrimination of single-point mutations in unamplified genomic DNA via Cas9 immobilized on a graphene field-effect transistor80
Antigen-bearing outer membrane vesicles as tumour vaccines produced in situ by ingested genetically engineered bacteria80
Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche80
Shifting machine learning for healthcare from development to deployment and from models to data80
T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours80
Rapid prototyping of soft bioelectronic implants for use as neuromuscular interfaces79
A CRISPR-based assay for the detection of opportunistic infections post-transplantation and for the monitoring of transplant rejection78
Simplified Cas13-based assays for the fast identification of SARS-CoV-2 and its variants77
A low-power band of neuronal spiking activity dominated by local single units improves the performance of brain–machine interfaces75
Enhanced intratumoural activity of CAR T cells engineered to produce immunomodulators under photothermal control75
Quantification of antibody avidities and accurate detection of SARS-CoV-2 antibodies in serum and saliva on plasmonic substrates75
Ultrasensitive detection of circulating tumour DNA via deep methylation sequencing aided by machine learning74
Nanoparticles with ultrasound-induced afterglow luminescence for tumour-specific theranostics73
Harnessing non-destructive 3D pathology73
Generation of hypoimmunogenic T cells from genetically engineered allogeneic human induced pluripotent stem cells72
Systemic immune responses to irradiated tumours via the transport of antigens to the tumour periphery by injected flagellate bacteria72
Performance benchmarking of microbubble-localization algorithms for ultrasound localization microscopy71
A phosphorescent probe for in vivo imaging in the second near-infrared window69
Gelling hypotonic polymer solution for extended topical drug delivery to the eye68
Suppression of the fibrotic encapsulation of silicone implants by inhibiting the mechanical activation of pro-fibrotic TGF-β68
Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors68
Biomimetic cartilage-lubricating polymers regenerate cartilage in rats with early osteoarthritis67
Power-saving design opportunities for wireless intracortical brain–computer interfaces67
Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts66
Matrix stiffness epigenetically regulates the oncogenic activation of the Yes-associated protein in gastric cancer66
Miniaturized electromechanical devices for the characterization of the biomechanics of deep tissue66
Mining for encrypted peptide antibiotics in the human proteome65
Detection of ovarian cancer via the spectral fingerprinting of quantum-defect-modified carbon nanotubes in serum by machine learning65
Development of vaccines and antivirals for combating viral pandemics65
Limitations and opportunities of technologies for the analysis of cell-free DNA in cancer diagnostics64
De novo development of proteolytically resistant therapeutic peptides for oral administration64
Gold/alpha-lactalbumin nanoprobes for the imaging and treatment of breast cancer63
Engineered reproductive tissues62
In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA62
A neurovascular-unit-on-a-chip for the evaluation of the restorative potential of stem cell therapies for ischaemic stroke62
An orally delivered microbial cocktail for the removal of nitrogenous metabolic waste in animal models of kidney failure62
Bioinspired kirigami metasurfaces as assistive shoe grips61
A low-power stretchable neuromorphic nerve with proprioceptive feedback61
Single-cell-resolved differentiation of human induced pluripotent stem cells into pancreatic duct-like organoids on a microwell chip61
Rapid detection of SARS-CoV-2 RNA in saliva via Cas1360
Chronic electrical stimulation of peripheral nerves via deep-red light transduced by an implanted organic photocapacitor60
Biomaterial-mediated modulation of oral microbiota synergizes with PD-1 blockade in mice with oral squamous cell carcinoma58
Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity56
Systemic tumour suppression via the preferential accumulation of erythrocyte-anchored chemokine-encapsulating nanoparticles in lung metastases56
Multiplexed imaging in oncology56
Graph representation learning in biomedicine and healthcare55
Enhancing the tropism of bacteria via genetically programmed biosensors55
Transient blood thinning during extracorporeal blood purification via the inactivation of coagulation factors by hydrogel microspheres55
Expert-level detection of pathologies from unannotated chest X-ray images via self-supervised learning55
Towards translational optogenetics54
Therapeutic vaccination against leukaemia via the sustained release of co-encapsulated anti-PD-1 and a leukaemia-associated antigen54
Decoding of facial strains via conformable piezoelectric interfaces54
Shear-stress sensing by PIEZO1 regulates tendon stiffness in rodents and influences jumping performance in humans53
High-resolution T1 MRI via renally clearable dextran nanoparticles with an iron oxide shell53
Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage53
Reduction of choroidal neovascularization via cleavable VEGF antibodies conjugated to exosomes derived from regulatory T cells52
A co-formulation of supramolecularly stabilized insulin and pramlintide enhances mealtime glucagon suppression in diabetic pigs51
Orthogonally induced differentiation of stem cells for the programmatic patterning of vascularized organoids and bioprinted tissues51
Human mini-brain models49
Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels48
Opportunities and challenges in the diagnostic utility of dermal interstitial fluid48
Cancer vaccines from cryogenically silicified tumour cells functionalized with pathogen-associated molecular patterns48
Synergistic checkpoint-blockade and radiotherapy–radiodynamic therapy via an immunomodulatory nanoscale metal–organic framework47
An organoid-based screen for epigenetic inhibitors that stimulate antigen presentation and potentiate T-cell-mediated cytotoxicity47
Site-specific PEGylation of interleukin-2 enhances immunosuppression via the sustained activation of regulatory T cells47
Wirelessly operated bioelectronic sutures for the monitoring of deep surgical wounds46
Deep brain stimulation by blood–brain-barrier-crossing piezoelectric nanoparticles generating current and nitric oxide under focused ultrasound46
CAR-T cells targeting a nucleophosmin neoepitope exhibit potent specific activity in mouse models of acute myeloid leukaemia45
Identification of potent antimicrobial peptides via a machine-learning pipeline that mines the entire space of peptide sequences45
Highly multiplexed rapid DNA detection with single-nucleotide specificity via convective PCR in a portable device45
Whole-body tracking of single cells via positron emission tomography45
Ultraflexible electrode arrays for months-long high-density electrophysiological mapping of thousands of neurons in rodents44
A fluorescence sandwich immunoassay for the real-time continuous detection of glucose and insulin in live animals44
Metabolically driven maturation of human-induced-pluripotent-stem-cell-derived cardiac microtissues on microfluidic chips44