Nature Biomedical Engineering

Article	Citations
Data-efficient and weakly supervised computational pathology on whole-slide images	639
The evolution of commercial drug delivery technologies	622
CRISPR-based diagnostics	555
Clinical validation of a Cas13-based assay for the detection of SARS-CoV-2 RNA	452
An epidermal patch for the simultaneous monitoring of haemodynamic and metabolic biomarkers	342
Pre-symptomatic detection of COVID-19 from smartwatch data	317
A wearable electrochemical biosensor for the monitoring of metabolites and nutrients	301
Synthetic data in machine learning for medicine and healthcare	288
Rapid single-molecule detection of COVID-19 and MERS antigens via nanobody-functionalized organic electrochemical transistors	251
A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics	245
An integrated wearable microneedle array for the continuous monitoring of multiple biomarkers in interstitial fluid	221
Rapid lateral flow immunoassay for the fluorescence detection of SARS-CoV-2 RNA	204
Microneedle patch for the ultrasensitive quantification of protein biomarkers in interstitial fluid	203
Optimization of lipid nanoparticles for the delivery of nebulized therapeutic mRNA to the lungs	199
Catheter-integrated soft multilayer electronic arrays for multiplexed sensing and actuation during cardiac surgery	192
Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets	191
A multi-organ chip with matured tissue niches linked by vascular flow	189
A soft neuroprosthetic hand providing simultaneous myoelectric control and tactile feedback	187
Tumour sensitization via the extended intratumoural release of a STING agonist and camptothecin from a self-assembled hydrogel	185
Prolonged activation of innate immune pathways by a polyvalent STING agonist	176
Accelerated antimicrobial discovery via deep generative models and molecular dynamics simulations	173
Rapid and ultrasensitive electromechanical detection of ions, biomolecules and SARS-CoV-2 RNA in unamplified samples	173
Transcranial ultrafast ultrasound localization microscopy of brain vasculature in patients	172
Rapid and coagulation-independent haemostatic sealing by a paste inspired by barnacle glue	172
Treatment of infarcted heart tissue via the capture and local delivery of circulating exosomes through antibody-conjugated magnetic nanoparticles	170

Wireless and battery-free technologies for neuroengineering	168
Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning	167
Enhanced tumour penetration and prolonged circulation in blood of polyzwitterion–drug conjugates with cell-membrane affinity	164
Fast detection of SARS-CoV-2 RNA via the integration of plasmonic thermocycling and fluorescence detection in a portable device	163
Self-supervised learning in medicine and healthcare	145
A deep-learning system for the assessment of cardiovascular disease risk via the measurement of retinal-vessel calibre	143
Sensitive fluorescence detection of SARS-CoV-2 RNA in clinical samples via one-pot isothermal ligation and transcription	137
Deep-learning models for the detection and incidence prediction of chronic kidney disease and type 2 diabetes from retinal fundus images	136
The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans	136
A lab-on-a-chip for the concurrent electrochemical detection of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in saliva and plasma	136
Fast and sensitive detection of SARS-CoV-2 RNA using suboptimal protospacer adjacent motifs for Cas12a	130
Open resource of clinical data from patients with pneumonia for the prediction of COVID-19 outcomes via deep learning	127
Prospective assessment of breast cancer risk from multimodal multiview ultrasound images via clinically applicable deep learning	126
Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow	124
Restoration of sensory information via bionic hands	123
Toward higher-performance bionic limbs for wider clinical use	121
Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine	118
Continuous monitoring of deep-tissue haemodynamics with stretchable ultrasonic phased arrays	116
Rapid manufacturing of non-activated potent CAR T cells	116
Transdermal microneedles for the programmable burst release of multiple vaccine payloads	116
Ultrasensitive high-resolution profiling of early seroconversion in patients with COVID-19	114
Shifting machine learning for healthcare from development to deployment and from models to data	114
Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity	114
Extensive germline genome engineering in pigs	113
A portable scanner for magnetic resonance imaging of the brain	112
A strain-programmed patch for the healing of diabetic wounds	112
Cryomicroneedles for transdermal cell delivery	112
A soft and transparent contact lens for the wireless quantitative monitoring of intraocular pressure	112
Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel	111
A deep-learning pipeline for the diagnosis and discrimination of viral, non-viral and COVID-19 pneumonia from chest X-ray images	111
Stimulation of neural stem cell differentiation by circularly polarized light transduced by chiral nanoassemblies	109
Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance	109
Identification of psychiatric disorder subtypes from functional connectivity patterns in resting-state electroencephalography	108
Enhancement of the blood-circulation time and performance of nanomedicines via the forced clearance of erythrocytes	107
A paper-based assay for the colorimetric detection of SARS-CoV-2 variants at single-nucleotide resolution	106
Lentiviral delivery of co-packaged Cas9 mRNA and a Vegfa-targeting guide RNA prevents wet age-related macular degeneration in mice	105
Massively parallel functional photoacoustic computed tomography of the human brain	105
Design and clinical implementation of an open-source bionic leg	105
Burst release of encapsulated annexin A5 in tumours boosts cytotoxic T-cell responses by blocking the phagocytosis of apoptotic cells	105
Tether-free photothermal deep-brain stimulation in freely behaving mice via wide-field illumination in the near-infrared-II window	104
An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma	101
Injectable and conductive cardiac patches repair infarcted myocardium in rats and minipigs	101
Exosome-eluting stents for vascular healing after ischaemic injury	101
Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy	101
A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves	99
Modelling and prediction of the dynamic responses of large-scale brain networks during direct electrical stimulation	98
Methotrexate-loaded tumour-cell-derived microvesicles can relieve biliary obstruction in patients with extrahepatic cholangiocarcinoma	98
Control of the activity of CAR-T cells within tumours via focused ultrasound	98
Neutralizing antibodies for the treatment of COVID-19	95
Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing	94

Classification of T-cell activation via autofluorescence lifetime imaging	94
Application of prime editing to the correction of mutations and phenotypes in adult mice with liver and eye diseases	93
Antigen-bearing outer membrane vesicles as tumour vaccines produced in situ by ingested genetically engineered bacteria	93
Nanoparticles with ultrasound-induced afterglow luminescence for tumour-specific theranostics	92
Limitations and opportunities of technologies for the analysis of cell-free DNA in cancer diagnostics	92
Fungal brain infection modelled in a human-neurovascular-unit-on-a-chip with a functional blood–brain barrier	92
Biomimetic cartilage-lubricating polymers regenerate cartilage in rats with early osteoarthritis	90
Simplified Cas13-based assays for the fast identification of SARS-CoV-2 and its variants	90
A web tool for the design of prime-editing guide RNAs	90
AND-gate contrast agents for enhanced fluorescence-guided surgery	90
T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours	88
Systemic immune responses to irradiated tumours via the transport of antigens to the tumour periphery by injected flagellate bacteria	87
Rapid prototyping of soft bioelectronic implants for use as neuromuscular interfaces	87
Discrimination of single-point mutations in unamplified genomic DNA via Cas9 immobilized on a graphene field-effect transistor	86
Harnessing non-destructive 3D pathology	84
A low-power band of neuronal spiking activity dominated by local single units improves the performance of brain–machine interfaces	82
Enhanced intratumoural activity of CAR T cells engineered to produce immunomodulators under photothermal control	81
Ultrasensitive detection of circulating tumour DNA via deep methylation sequencing aided by machine learning	81
Generation of hypoimmunogenic T cells from genetically engineered allogeneic human induced pluripotent stem cells	81
Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche	80
Performance benchmarking of microbubble-localization algorithms for ultrasound localization microscopy	80
Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts	79
Detection of ovarian cancer via the spectral fingerprinting of quantum-defect-modified carbon nanotubes in serum by machine learning	79
Quantification of antibody avidities and accurate detection of SARS-CoV-2 antibodies in serum and saliva on plasmonic substrates	78
Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors	78
A phosphorescent probe for in vivo imaging in the second near-infrared window	77
Graph representation learning in biomedicine and healthcare	74
Suppression of the fibrotic encapsulation of silicone implants by inhibiting the mechanical activation of pro-fibrotic TGF-β	74
Biomaterial-mediated modulation of oral microbiota synergizes with PD-1 blockade in mice with oral squamous cell carcinoma	73
A low-power stretchable neuromorphic nerve with proprioceptive feedback	73
Expert-level detection of pathologies from unannotated chest X-ray images via self-supervised learning	73
Power-saving design opportunities for wireless intracortical brain–computer interfaces	73
Opportunities and challenges in the diagnostic utility of dermal interstitial fluid	72
Matrix stiffness epigenetically regulates the oncogenic activation of the Yes-associated protein in gastric cancer	72
In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA	72
Gelling hypotonic polymer solution for extended topical drug delivery to the eye	72
Towards translational optogenetics	71
Development of vaccines and antivirals for combating viral pandemics	71
Miniaturized electromechanical devices for the characterization of the biomechanics of deep tissue	71
Chronic electrical stimulation of peripheral nerves via deep-red light transduced by an implanted organic photocapacitor	70
Mining for encrypted peptide antibiotics in the human proteome	69
Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity	69
Algorithmic fairness in artificial intelligence for medicine and healthcare	67
Rapid detection of SARS-CoV-2 RNA in saliva via Cas13	67
An orally delivered microbial cocktail for the removal of nitrogenous metabolic waste in animal models of kidney failure	67
Single-cell-resolved differentiation of human induced pluripotent stem cells into pancreatic duct-like organoids on a microwell chip	66
Multiplexed imaging in oncology	66
A neurovascular-unit-on-a-chip for the evaluation of the restorative potential of stem cell therapies for ischaemic stroke	65
Gold/alpha-lactalbumin nanoprobes for the imaging and treatment of breast cancer	65
A wireless patch for the monitoring of C-reactive protein in sweat	64
Orthogonally induced differentiation of stem cells for the programmatic patterning of vascularized organoids and bioprinted tissues	63
High-resolution T1 MRI via renally clearable dextran nanoparticles with an iron oxide shell	62
Shear-stress sensing by PIEZO1 regulates tendon stiffness in rodents and influences jumping performance in humans	62
Systemic tumour suppression via the preferential accumulation of erythrocyte-anchored chemokine-encapsulating nanoparticles in lung metastases	61
Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage	61
Transient blood thinning during extracorporeal blood purification via the inactivation of coagulation factors by hydrogel microspheres	60
Identification of potent antimicrobial peptides via a machine-learning pipeline that mines the entire space of peptide sequences	59
Enhancing the tropism of bacteria via genetically programmed biosensors	59
Deep brain stimulation by blood–brain-barrier-crossing piezoelectric nanoparticles generating current and nitric oxide under focused ultrasound	58
Therapeutic vaccination against leukaemia via the sustained release of co-encapsulated anti-PD-1 and a leukaemia-associated antigen	57
Decoding of facial strains via conformable piezoelectric interfaces	56
Reduction of choroidal neovascularization via cleavable VEGF antibodies conjugated to exosomes derived from regulatory T cells	56
Ultraflexible electrode arrays for months-long high-density electrophysiological mapping of thousands of neurons in rodents	56
Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy	56
Wirelessly operated bioelectronic sutures for the monitoring of deep surgical wounds	55
An organoid-based screen for epigenetic inhibitors that stimulate antigen presentation and potentiate T-cell-mediated cytotoxicity	54
Spatially resolved in vivo imaging of inflammation-associated mRNA via enzymatic fluorescence amplification in a molecular beacon	54
A one-pot isothermal Cas12-based assay for the sensitive detection of microRNAs	53
Production of human spinal-cord organoids recapitulating neural-tube morphogenesis	53
Label-free intraoperative histology of bone tissue via deep-learning-assisted ultraviolet photoacoustic microscopy	52
Site-specific PEGylation of interleukin-2 enhances immunosuppression via the sustained activation of regulatory T cells	51
Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels	51
A fluorescence sandwich immunoassay for the real-time continuous detection of glucose and insulin in live animals	51
Cancer vaccines from cryogenically silicified tumour cells functionalized with pathogen-associated molecular patterns	51
Human mini-brain models	50
Synergistic checkpoint-blockade and radiotherapy–radiodynamic therapy via an immunomodulatory nanoscale metal–organic framework	50
Metabolically driven maturation of human-induced-pluripotent-stem-cell-derived cardiac microtissues on microfluidic chips	49
Treatment of peanut allergy and colitis in mice via the intestinal release of butyrate from polymeric micelles	48
Highly multiplexed rapid DNA detection with single-nucleotide specificity via convective PCR in a portable device	48
Genetically engineered and enucleated human mesenchymal stromal cells for the targeted delivery of therapeutics to diseased tissue	48

Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles	48
Graph deep learning for the characterization of tumour microenvironments from spatial protein profiles in tissue specimens	48
Computational reconstruction of the signalling networks surrounding implanted biomaterials from single-cell transcriptomics	47
Tracking the expression of therapeutic protein targets in rare cells by antibody-mediated nanoparticle labelling and magnetic sorting	47
Multiscale optical and optoacoustic imaging of amyloid-β deposits in mice	47
In vivo lensless microscopy via a phase mask generating diffraction patterns with high-contrast contours	47
Opportunities and challenges in the development of exoskeletons for locomotor assistance	46
Nuclear deformation guides chromatin reorganization in cardiac development and disease	46
A dysfunctional TRPV4–GSK3β pathway prevents osteoarthritic chondrocytes from sensing changes in extracellular matrix viscoelasticity	46