Nature Biomedical Engineering

Papers
(The TQCC of Nature Biomedical Engineering is 43. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)
ArticleCitations
Author Correction: Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation815
A humanized minipig model for the toxicological testing of therapeutic recombinant antibodies511
Synaptic connectivity mapping among thousands of neurons via parallelized intracellular recording with a microhole electrode array426
Rapid and stain-free quantification of viral plaque via lens-free holography and deep learning358
Induction of antigen-specific tolerance by nanobody–antigen adducts that target class-II major histocompatibility complexes318
A data-efficient strategy for building high-performing medical foundation models314
Deep mutational learning for the selection of therapeutic antibodies resistant to the evolution of Omicron variants of SARS-CoV-2306
Author Correction: Prolonged activation of innate immune pathways by a polyvalent STING agonist297
An implantable hydrogel-based phononic crystal for continuous and wireless monitoring of internal tissue strains276
A nanoparticle probe for the imaging of autophagic flux in live mice via magnetic resonance and near-infrared fluorescence267
Systemic immune responses to irradiated tumours via the transport of antigens to the tumour periphery by injected flagellate bacteria247
An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma243
Sensitive detection of SARS-CoV-2 on paper227
Solid stress impairs lymphocyte infiltration into lymph-node metastases216
A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics208
A soft and transparent contact lens for the wireless quantitative monitoring of intraocular pressure203
A strain-programmed patch for the healing of diabetic wounds201
Adaptive adversarial neural networks for the analysis of lossy and domain-shifted datasets of medical images194
Linking the genotypes and phenotypes of cancer cells in heterogenous populations via real-time optical tagging and image analysis193
Modelling ciliopathy phenotypes in human tissues derived from pluripotent stem cells with genetically ablated cilia189
Large DNA deletions occur during DNA repair at 20-fold lower frequency for base editors and prime editors than for Cas9 nucleases183
Unbiased discovery of autoantibodies associated with severe COVID-19 via genome-scale self-assembled DNA-barcoded protein libraries182
Biomaterial-induced conversion of quiescent cardiomyocytes into pacemaker cells in rats182
Publisher Correction: Restoration of sensory feedback from the foot and reduction of phantom limb pain via closed-loop spinal cord stimulation181
Downregulating human leucocyte antigens on mesenchymal stromal cells by epigenetically repressing a β2-microglobulin super-enhancer179
FAS-less allogeneic CAR T cells172
Author Correction: Endocisternal interfaces for minimally invasive neural stimulation and recording of the brain and spinal cord172
Streamlining point-of-care assays171
Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation169
Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage169
Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington’s disease166
A high-density microfluidic bioreactor for the automated manufacturing of CAR T cells165
Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity162
Fast and sensitive electromechanical sensing161
Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions156
Simultaneous visualization of multiple radionuclides in vivo155
Faster detection of somatic structural variants153
Probing when dCas9 tolerates DNA mismatches150
Prevention and treatment of peri-implant fibrosis by functionally inhibiting skeletal cells expressing the leptin receptor148
Offbeat drug-delivery tactics145
An organoid-based screen for epigenetic inhibitors that stimulate antigen presentation and potentiate T-cell-mediated cytotoxicity144
Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker143
Engineered allogeneic T cells decoupling T-cell-receptor and CD3 signalling enhance the antitumour activity of bispecific antibodies143
A base editor for the long-term restoration of auditory function in mice with recessive profound deafness142
Making fitter cells and tissues140
Generation of antigen-specific mature T cells from RAG1−/−RAG2−/−B2M−/− stem cells by engineering their microenvironment135
Augmented lipid-nanoparticle-mediated in vivo genome editing in the lungs and spleen by disrupting Cas9 activity in the liver134
A deep-learning model for quantifying circulating tumour DNA from the density distribution of DNA-fragment lengths133
Immune-privileged tissues formed from immunologically cloaked mouse embryonic stem cells survive long term in allogeneic hosts131
A knockout run for CRISPRed cells130
A two-phase point-of-care diagnostic device for bladder cancer129
Sensing haemodynamics via wearables in sync127
Subcutaneous pancreatic islet transplantation without immunosuppression127
Challenges and opportunities of acquiring cortical recordings for chronic adaptive deep brain stimulation124
Making MRI increasingly useful123
Reprogramming of fibroblasts into expandable cardiovascular progenitor cells via small molecules in xeno-free conditions121
An off-the-shelf otoacoustic-emission probe for hearing screening via a smartphone121
Targeting vaccines to dendritic cells by mimicking the processing and presentation of antigens in xenotransplant rejection119
1H magnetic resonance spectroscopic imaging of deuterated glucose and of neurotransmitter metabolism at 7 T in the human brain118
Reduction of choroidal neovascularization via cleavable VEGF antibodies conjugated to exosomes derived from regulatory T cells118
A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples116
A paper-based assay for the colorimetric detection of SARS-CoV-2 variants at single-nucleotide resolution114
Mapping light distribution in tissue by using MRI-detectable photosensitive liposomes111
A bilingual speech neuroprosthesis driven by cortical articulatory representations shared between languages108
Mapping tissue heterogeneity in solid tumours using PET–MRI and machine learning108
Machine learning in translation106
Straightforward, inexpensive and sensitive104
Mutation corrections in spinal muscular atrophy103
Allometrically scaling tissue forces drive pathological foreign-body responses to implants via Rac2-activated myeloid cells101
Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells100
Deep screening of antibody–antigen affinities100
Author Correction: Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTENmRNA99
Eyeing severe diabetes upfront99
Publisher Correction: Efficient in vivo base editing via single adenoassociated viruses with size-optimized genomes encoding compact adenine base editors99
Isolation of tumour-reactive lymphocytes from peripheral blood via microfluidic immunomagnetic cell sorting98
Ablation of FAS confers allogeneic CD3– CAR T cells with resistance to rejection by T cells and natural killer cells98
Targeted desialylation and cytolysis of tumour cells by fusing a sialidase to a bispecific T-cell engager97
A serine-conjugated butyrate prodrug with high oral bioavailability suppresses autoimmune arthritis and neuroinflammation in mice95
Enhancement of the viability of T cells electroporated with DNA via osmotic dampening of the DNA-sensing cGAS–STING pathway93
Screening for lipid nanoparticles that modulate the immune activity of helper T cells towards enhanced antitumour activity92
CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers90
An injectable subcutaneous colon-specific immune niche for the treatment of ulcerative colitis89
Rapid adaptation of brain–computer interfaces to new neuronal ensembles or participants via generative modelling89
Opportunities and challenges in the development of exoskeletons for locomotor assistance88
Peptide-mediated delivery of CRISPR enzymes for the efficient editing of primary human lymphocytes87
A battery-less wireless implant for the continuous monitoring of vascular pressure, flow rate and temperature85
Profiling protein–protein interactions to predict the efficacy of B-cell-lymphoma-2-homology-3 mimetics for acute myeloid leukaemia84
Osteopontin attenuates the foreign-body response to silicone implants84
Induction and expansion of human PRRX1+ limb-bud-like mesenchymal cells from pluripotent stem cells82
Explaining counterfactual images78
Author Correction: Generation of model tissues with dendritic vascular networks via sacrificial laser-sintered carbohydrate templates78
Insulin independence from stem-cell-derived islets78
Addendum: A tissue-engineered scale model of the heart ventricle77
Author Correction: Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNA77
Author Correction: Thermally sentient bionic limbs77
Concurrently depleting regulatory T cells and activating cytotoxic T cells in tumours76
Antibiotic-mediated selection of randomly mutagenized and cytokine-expressing oncolytic viruses74
Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samples73
Mineralized bacteria as an immunotherapy agent against various cancer types73
Spatial multi-omics at subcellular resolution via high-throughput in situ pairwise sequencing72
Opportunities and challenges in cardiac tissue engineering from an analysis of two decades of advances71
Potent prophylactic cancer vaccines harnessing surface antigens shared by tumour cells and induced pluripotent stem cells71
Multi-antigen spherical nucleic acid cancer vaccines70
A prototype closed-loop brain–machine interface for the study and treatment of pain69
Mining for encrypted peptide antibiotics in the human proteome67
Rational immunosilencing of a promiscuous T-cell epitope in the capsid of an adeno-associated virus66
Generation of T-cell-receptor-negative CD8αβ-positive CAR T cells from T-cell-derived induced pluripotent stem cells65
Synthetic data in machine learning for medicine and healthcare64
Enhanced intratumoural activity of CAR T cells engineered to produce immunomodulators under photothermal control64
Synthetic libraries of immune cells displaying a diverse repertoire of chimaeric antigen receptors as a potent cancer immunotherapy63
Tooling up against mechanobiological orthodoxy62
Write accessibly62
Base editing ablates all protein-coding genes of the mitochondrial genome in mouse cells62
A window into solid stresses within tumours61
Publisher Correction: Targeting overexpressed antigens in glioblastoma via CAR T cells with computationally designed high-affinity protein binders61
Antitumour vaccination via the targeted proteolysis of antigens isolated from tumour lysates61
Efficient circular RNA synthesis for potent rolling circle translation59
Field validation of the performance of paper-based tests for the detection of the Zika and chikungunya viruses in serum samples59
Efficient production of non-immunogenic, long circular RNAs for high protein yield59
Derivation of prognostic contextual histopathological features from whole-slide images of tumours via graph deep learning58
Neutrophils bearing adhesive polymer micropatches as a drug-free cancer immunotherapy58
Meta-analysis of the make-up and properties of in vitro models of the healthy and diseased blood–brain barrier57
Antigen-bearing outer membrane vesicles as tumour vaccines produced in situ by ingested genetically engineered bacteria57
Generation of neural organoids for spinal-cord regeneration via the direct reprogramming of human astrocytes56
Control of the antitumour activity and specificity of CAR T cells via organic adapters covalently tethering the CAR to tumour cells55
Towards handy neural prostheses55
Single-cell analysis of ductal differentiation55
How to make cover letters instructive55
Author Correction: Targeted tumour theranostics in mice via carbon quantum dots structurally mimicking large amino acids54
Mapping and targeted viral activation of pancreatic nerves in mice reveal their roles in the regulation of glucose metabolism54
Overcoming immune hurdles to implant longevity54
Seeing ageing through retinal images54
Patterned gastrointestinal monolayers with bilateral access as observable models of parasite gut infection53
Lipid nanoparticles for the inhalation of mRNA53
Identification of druggable regulators of cell secretion via a kinome-wide screen and high-throughput immunomagnetic cell sorting53
Single-cell-resolved differentiation of human induced pluripotent stem cells into pancreatic duct-like organoids on a microwell chip53
Rejuvenation of tumour-specific T cells through bispecific antibodies targeting PD-L1 on dendritic cells52
Aberrant chromatin reorganization in cells from diseased fibrous connective tissue in response to altered chemomechanical cues52
Wirelessly operated bioelectronic sutures for the monitoring of deep surgical wounds51
Nutritional deficiency in an intestine-on-a-chip recapitulates injury hallmarks associated with environmental enteric dysfunction51
Optimization of base editors for the functional correction of SMN2 as a treatment for spinal muscular atrophy51
T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours51
Designing stable humanized antibodies51
DNA-based computation for multiple biomarkers51
Fluorescence lifetime of injected indocyanine green as a universal marker of solid tumours in patients50
Immunization against Zika by entrapping live virus in a subcutaneous self-adjuvanting hydrogel50
A one-pot isothermal Cas12-based assay for the sensitive detection of microRNAs50
Continuous monitoring of deep-tissue haemodynamics with stretchable ultrasonic phased arrays49
Stimulating localizable sensations49
A low-power stretchable neuromorphic nerve with proprioceptive feedback49
Arrayed CRISPR libraries for the genome-wide activation, deletion and silencing of human protein-coding genes48
Streamlined detection of SARS-CoV-2 via Cas1348
Targeted knock-ins with pseudovirus for the stable expression of large transgenes48
Quantification of intratumoural heterogeneity in mice and patients via machine-learning models trained on PET–MRI data47
Contextual learning is nearly all you need47
Assessing the toxicity of bispecific antibodies47
Endocisternal interfaces for minimally invasive neural stimulation and recording of the brain and spinal cord47
Cas9-induced targeted integration of large DNA payloads in primary human T cells via homology-mediated end-joining DNA repair46
A swallowable X-ray dosimeter46
Clinical validation of a wearable ultrasound sensor of blood pressure45
Dynamical flexible inference of nonlinear latent factors and structures in neural population activity45
Hormonally mediated mechanical remodelling of human haematopoietic stem cells enhances their bone-marrow engraftment45
Rapid single-molecule detection of COVID-19 and MERS antigens via nanobody-functionalized organic electrochemical transistors44
Localized butyrate restores gut homeostasis44
Elimination of acquired resistance to PD-1 blockade via the concurrent depletion of tumour cells and immunosuppressive cells43
Reinforcement of the intestinal mucosal barrier via mucus-penetrating PEGylated bacteria43
A swallowable X-ray dosimeter for the real-time monitoring of radiotherapy43
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