Nature Biomedical Engineering

Article	Citations
Data-efficient and weakly supervised computational pathology on whole-slide images	758
The evolution of commercial drug delivery technologies	699
CRISPR-based diagnostics	625
An epidermal patch for the simultaneous monitoring of haemodynamic and metabolic biomarkers	387
A wearable electrochemical biosensor for the monitoring of metabolites and nutrients	367
Pre-symptomatic detection of COVID-19 from smartwatch data	332
Synthetic data in machine learning for medicine and healthcare	325
Rapid single-molecule detection of COVID-19 and MERS antigens via nanobody-functionalized organic electrochemical transistors	271
A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics	265
An integrated wearable microneedle array for the continuous monitoring of multiple biomarkers in interstitial fluid	262
Optimization of lipid nanoparticles for the delivery of nebulized therapeutic mRNA to the lungs	232
Microneedle patch for the ultrasensitive quantification of protein biomarkers in interstitial fluid	221
A multi-organ chip with matured tissue niches linked by vascular flow	218
Rapid lateral flow immunoassay for the fluorescence detection of SARS-CoV-2 RNA	214
A soft neuroprosthetic hand providing simultaneous myoelectric control and tactile feedback	204
Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets	204
Rapid and ultrasensitive electromechanical detection of ions, biomolecules and SARS-CoV-2 RNA in unamplified samples	196
Transcranial ultrafast ultrasound localization microscopy of brain vasculature in patients	193
Accelerated antimicrobial discovery via deep generative models and molecular dynamics simulations	190
Rapid and coagulation-independent haemostatic sealing by a paste inspired by barnacle glue	188
Self-supervised learning in medicine and healthcare	187
Prolonged activation of innate immune pathways by a polyvalent STING agonist	184
Treatment of infarcted heart tissue via the capture and local delivery of circulating exosomes through antibody-conjugated magnetic nanoparticles	184
Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning	182
Enhanced tumour penetration and prolonged circulation in blood of polyzwitterion–drug conjugates with cell-membrane affinity	181

Wireless and battery-free technologies for neuroengineering	178
Fast detection of SARS-CoV-2 RNA via the integration of plasmonic thermocycling and fluorescence detection in a portable device	173
Deep-learning models for the detection and incidence prediction of chronic kidney disease and type 2 diabetes from retinal fundus images	161
A lab-on-a-chip for the concurrent electrochemical detection of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in saliva and plasma	149
Fast and sensitive detection of SARS-CoV-2 RNA using suboptimal protospacer adjacent motifs for Cas12a	148
The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans	145
Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow	143
Continuous monitoring of deep-tissue haemodynamics with stretchable ultrasonic phased arrays	141
Prospective assessment of breast cancer risk from multimodal multiview ultrasound images via clinically applicable deep learning	140
A strain-programmed patch for the healing of diabetic wounds	136
Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine	134
Shifting machine learning for healthcare from development to deployment and from models to data	133
Toward higher-performance bionic limbs for wider clinical use	132
Rapid manufacturing of non-activated potent CAR T cells	132
Open resource of clinical data from patients with pneumonia for the prediction of COVID-19 outcomes via deep learning	132
Restoration of sensory information via bionic hands	131
Cryomicroneedles for transdermal cell delivery	130
Transdermal microneedles for the programmable burst release of multiple vaccine payloads	129
A soft and transparent contact lens for the wireless quantitative monitoring of intraocular pressure	128
Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel	125
Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity	124
A portable scanner for magnetic resonance imaging of the brain	121
Tether-free photothermal deep-brain stimulation in freely behaving mice via wide-field illumination in the near-infrared-II window	119
A deep-learning pipeline for the diagnosis and discrimination of viral, non-viral and COVID-19 pneumonia from chest X-ray images	118
Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance	118
A paper-based assay for the colorimetric detection of SARS-CoV-2 variants at single-nucleotide resolution	116
Massively parallel functional photoacoustic computed tomography of the human brain	115
Exosome-eluting stents for vascular healing after ischaemic injury	114
Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy	114
Limitations and opportunities of technologies for the analysis of cell-free DNA in cancer diagnostics	113
Expert-level detection of pathologies from unannotated chest X-ray images via self-supervised learning	113
Injectable and conductive cardiac patches repair infarcted myocardium in rats and minipigs	113
Lentiviral delivery of co-packaged Cas9 mRNA and a Vegfa-targeting guide RNA prevents wet age-related macular degeneration in mice	111
Control of the activity of CAR-T cells within tumours via focused ultrasound	110
Nanoparticles with ultrasound-induced afterglow luminescence for tumour-specific theranostics	110
A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves	110
An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma	108
Fungal brain infection modelled in a human-neurovascular-unit-on-a-chip with a functional blood–brain barrier	105
Simplified Cas13-based assays for the fast identification of SARS-CoV-2 and its variants	104
Antigen-bearing outer membrane vesicles as tumour vaccines produced in situ by ingested genetically engineered bacteria	102
Biomimetic cartilage-lubricating polymers regenerate cartilage in rats with early osteoarthritis	101
Systemic immune responses to irradiated tumours via the transport of antigens to the tumour periphery by injected flagellate bacteria	101
Application of prime editing to the correction of mutations and phenotypes in adult mice with liver and eye diseases	100
Performance benchmarking of microbubble-localization algorithms for ultrasound localization microscopy	100
T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours	99
Modelling and prediction of the dynamic responses of large-scale brain networks during direct electrical stimulation	99
Algorithmic fairness in artificial intelligence for medicine and healthcare	97
Neutralizing antibodies for the treatment of COVID-19	96
Generation of hypoimmunogenic T cells from genetically engineered allogeneic human induced pluripotent stem cells	94
Harnessing non-destructive 3D pathology	93

A one-pot isothermal Cas12-based assay for the sensitive detection of microRNAs	93
Discrimination of single-point mutations in unamplified genomic DNA via Cas9 immobilized on a graphene field-effect transistor	92
Graph representation learning in biomedicine and healthcare	92
Opportunities and challenges in the diagnostic utility of dermal interstitial fluid	91
A phosphorescent probe for in vivo imaging in the second near-infrared window	91
Detection of ovarian cancer via the spectral fingerprinting of quantum-defect-modified carbon nanotubes in serum by machine learning	91
Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts	90
A wireless patch for the monitoring of C-reactive protein in sweat	89
Ultrasensitive detection of circulating tumour DNA via deep methylation sequencing aided by machine learning	89
A low-power stretchable neuromorphic nerve with proprioceptive feedback	88
Enhanced intratumoural activity of CAR T cells engineered to produce immunomodulators under photothermal control	87
Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors	86
Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity	83
Mining for encrypted peptide antibiotics in the human proteome	82
Miniaturized electromechanical devices for the characterization of the biomechanics of deep tissue	80
Suppression of the fibrotic encapsulation of silicone implants by inhibiting the mechanical activation of pro-fibrotic TGF-β	79
Biomaterial-mediated modulation of oral microbiota synergizes with PD-1 blockade in mice with oral squamous cell carcinoma	78
Rapid detection of SARS-CoV-2 RNA in saliva via Cas13	78
Towards translational optogenetics	78
Chronic electrical stimulation of peripheral nerves via deep-red light transduced by an implanted organic photocapacitor	77
Matrix stiffness epigenetically regulates the oncogenic activation of the Yes-associated protein in gastric cancer	77
Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy	76
In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA	74
Development of vaccines and antivirals for combating viral pandemics	73
A neurovascular-unit-on-a-chip for the evaluation of the restorative potential of stem cell therapies for ischaemic stroke	72
Multiplexed imaging in oncology	72
Identification of potent antimicrobial peptides via a machine-learning pipeline that mines the entire space of peptide sequences	71
Enhancing the tropism of bacteria via genetically programmed biosensors	70
Label-free intraoperative histology of bone tissue via deep-learning-assisted ultraviolet photoacoustic microscopy	69
Deep brain stimulation by blood–brain-barrier-crossing piezoelectric nanoparticles generating current and nitric oxide under focused ultrasound	68
Single-cell-resolved differentiation of human induced pluripotent stem cells into pancreatic duct-like organoids on a microwell chip	67
High-resolution T1 MRI via renally clearable dextran nanoparticles with an iron oxide shell	67
Orthogonally induced differentiation of stem cells for the programmatic patterning of vascularized organoids and bioprinted tissues	67
Systemic tumour suppression via the preferential accumulation of erythrocyte-anchored chemokine-encapsulating nanoparticles in lung metastases	66
Ultraflexible electrode arrays for months-long high-density electrophysiological mapping of thousands of neurons in rodents	66
Shear-stress sensing by PIEZO1 regulates tendon stiffness in rodents and influences jumping performance in humans	66
A transformer-based representation-learning model with unified processing of multimodal input for clinical diagnostics	65
Reduction of choroidal neovascularization via cleavable VEGF antibodies conjugated to exosomes derived from regulatory T cells	63
Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage	63
Opportunities and challenges in the development of exoskeletons for locomotor assistance	63
Transient blood thinning during extracorporeal blood purification via the inactivation of coagulation factors by hydrogel microspheres	63
Spatially resolved in vivo imaging of inflammation-associated mRNA via enzymatic fluorescence amplification in a molecular beacon	62
Wirelessly operated bioelectronic sutures for the monitoring of deep surgical wounds	62
An organoid-based screen for epigenetic inhibitors that stimulate antigen presentation and potentiate T-cell-mediated cytotoxicity	62
Production of human spinal-cord organoids recapitulating neural-tube morphogenesis	62
Cancer vaccines from cryogenically silicified tumour cells functionalized with pathogen-associated molecular patterns	62
Graph deep learning for the characterization of tumour microenvironments from spatial protein profiles in tissue specimens	59
Synergistic checkpoint-blockade and radiotherapy–radiodynamic therapy via an immunomodulatory nanoscale metal–organic framework	59
Site-specific PEGylation of interleukin-2 enhances immunosuppression via the sustained activation of regulatory T cells	58
Genetically engineered and enucleated human mesenchymal stromal cells for the targeted delivery of therapeutics to diseased tissue	57
Activatable near-infrared probes for the detection of specific populations of tumour-infiltrating leukocytes in vivo and in urine	57
Robust and data-efficient generalization of self-supervised machine learning for diagnostic imaging	56
Highly multiplexed rapid DNA detection with single-nucleotide specificity via convective PCR in a portable device	56
A fluorescence sandwich immunoassay for the real-time continuous detection of glucose and insulin in live animals	55
Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels	55
Treatment of peanut allergy and colitis in mice via the intestinal release of butyrate from polymeric micelles	55
In vivo lensless microscopy via a phase mask generating diffraction patterns with high-contrast contours	54
Computational reconstruction of the signalling networks surrounding implanted biomaterials from single-cell transcriptomics	54
A dysfunctional TRPV4–GSK3β pathway prevents osteoarthritic chondrocytes from sensing changes in extracellular matrix viscoelasticity	53
Human mini-brain models	53
Ultrasensitive lateral-flow assays via plasmonically active antibody-conjugated fluorescent nanoparticles	53
Ex vivo prime editing of patient haematopoietic stem cells rescues sickle-cell disease phenotypes after engraftment in mice	52
Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles	52
Multiscale optical and optoacoustic imaging of amyloid-β deposits in mice	51
Metabolically driven maturation of human-induced-pluripotent-stem-cell-derived cardiac microtissues on microfluidic chips	51
An engineered live biotherapeutic for the prevention of antibiotic-induced dysbiosis	50
A wireless and battery-less implant for multimodal closed-loop neuromodulation in small animals	50
Fast and scalable search of whole-slide images via self-supervised deep learning	50
Nuclear deformation guides chromatin reorganization in cardiac development and disease	49
A battery-less wireless implant for the continuous monitoring of vascular pressure, flow rate and temperature	47
Intraoperative imaging in pathology-assisted surgery	47
Solid stress impairs lymphocyte infiltration into lymph-node metastases	46
High-speed light-sheet microscopy for the in-situ acquisition of volumetric histological images of living tissue	46
Massively scaled-up testing for SARS-CoV-2 RNA via next-generation sequencing of pooled and barcoded nasal and saliva samples	46
Massively parallel enrichment of low-frequency alleles enables duplex sequencing at low depth	45
Augmented lipid-nanoparticle-mediated in vivo genome editing in the lungs and spleen by disrupting Cas9 activity in the liver	44
Revealing nanostructures in brain tissue via protein decrowding by iterative expansion microscopy	44
Derivation of prognostic contextual histopathological features from whole-slide images of tumours via graph deep learning	44
Mechanobiological conditioning of mesenchymal stem cells for enhanced vascular regeneration	43
Detection of signs of disease in external photographs of the eyes via deep learning	43

Field validation of the performance of paper-based tests for the detection of the Zika and chikungunya viruses in serum samples	43
Efficient recovery of potent tumour-infiltrating lymphocytes through quantitative immunomagnetic cell sorting	42
Peptide-mediated delivery of CRISPR enzymes for the efficient editing of primary human lymphocytes	42
Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker	42
Conjugation of glucosylated polymer chains to checkpoint blockade antibodies augments their efficacy and specificity for glioblastoma	42
Rejuvenation of tumour-specific T cells through bispecific antibodies targeting PD-L1 on dendritic cells	42