Nature Biomedical Engineering

Article	Citations
Author Correction: Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation	609
Emergency delivery of particulate drugs by active ejection using in vivo wireless devices	422
A nanoparticle probe for the imaging of autophagic flux in live mice via magnetic resonance and near-infrared fluorescence	374
Sensitive detection of SARS-CoV-2 on paper	356
Deep mutational learning for the selection of therapeutic antibodies resistant to the evolution of Omicron variants of SARS-CoV-2	322
A humanized minipig model for the toxicological testing of therapeutic recombinant antibodies	299
Rapid and stain-free quantification of viral plaque via lens-free holography and deep learning	275
Neuroimaging endophenotypes reveal underlying mechanisms and genetic factors contributing to progression and development of four brain disorders	265
A data-efficient strategy for building high-performing medical foundation models	263
Synaptic connectivity mapping among thousands of neurons via parallelized intracellular recording with a microhole electrode array	233
Systemic immune responses to irradiated tumours via the transport of antigens to the tumour periphery by injected flagellate bacteria	233
An implantable hydrogel-based phononic crystal for continuous and wireless monitoring of internal tissue strains	228
A strain-programmed patch for the healing of diabetic wounds	223
Publisher Correction: Restoration of sensory feedback from the foot and reduction of phantom limb pain via closed-loop spinal cord stimulation	215
Linking the genotypes and phenotypes of cancer cells in heterogenous populations via real-time optical tagging and image analysis	215
Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation	214
Streamlining point-of-care assays	213
Ultrasensitive and long-lasting bioluminescence immunoassay for point-of-care viral antigen detection	206
A sonosensitive diphenylalanine-based broad-spectrum antimicrobial peptide	202
Modelling ciliopathy phenotypes in human tissues derived from pluripotent stem cells with genetically ablated cilia	201
FAS-less allogeneic CAR T cells	194
A high-density microfluidic bioreactor for the automated manufacturing of CAR T cells	186
Author Correction: Endocisternal interfaces for minimally invasive neural stimulation and recording of the brain and spinal cord	182
A generative model uses healthy and diseased image pairs for pixel-level chest X-ray pathology localization	179
Biomaterial-induced conversion of quiescent cardiomyocytes into pacemaker cells in rats	178

Unbiased discovery of autoantibodies associated with severe COVID-19 via genome-scale self-assembled DNA-barcoded protein libraries	176
Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington’s disease	175
Large DNA deletions occur during DNA repair at 20-fold lower frequency for base editors and prime editors than for Cas9 nucleases	172
Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity	168
Fast and sensitive electromechanical sensing	165
Downregulating human leucocyte antigens on mesenchymal stromal cells by epigenetically repressing a β2-microglobulin super-enhancer	165
Faster detection of somatic structural variants	164
Probing when dCas9 tolerates DNA mismatches	152
Generation of antigen-specific mature T cells from RAG1−/−RAG2−/−B2M−/− stem cells by engineering their microenvironment	144
Making fitter cells and tissues	144
A deep-learning model for quantifying circulating tumour DNA from the density distribution of DNA-fragment lengths	143
Offbeat drug-delivery tactics	140
Prevention and treatment of peri-implant fibrosis by functionally inhibiting skeletal cells expressing the leptin receptor	137
Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions	136
Targeting inflammation with chimeric antigen receptor macrophages using a signal switch	133
Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker	130
Engineered allogeneic T cells decoupling T-cell-receptor and CD3 signalling enhance the antitumour activity of bispecific antibodies	128
Augmented lipid-nanoparticle-mediated in vivo genome editing in the lungs and spleen by disrupting Cas9 activity in the liver	127
An organoid-based screen for epigenetic inhibitors that stimulate antigen presentation and potentiate T-cell-mediated cytotoxicity	125
A base editor for the long-term restoration of auditory function in mice with recessive profound deafness	122
Simultaneous visualization of multiple radionuclides in vivo	120
Potentiating cancer immunotherapies with modular albumin-hitchhiking nanobody–STING agonist conjugates	119
Immune-privileged tissues formed from immunologically cloaked mouse embryonic stem cells survive long term in allogeneic hosts	118
A knockout run for CRISPRed cells	116
Subcutaneous pancreatic islet transplantation without immunosuppression	112
Sensing haemodynamics via wearables in sync	110
Challenges and opportunities of acquiring cortical recordings for chronic adaptive deep brain stimulation	109
Mapping light distribution in tissue by using MRI-detectable photosensitive liposomes	105
Making MRI increasingly useful	102
Nanobody-based bispecific antibody engagers targeting CTLA-4 or PD-L1 for cancer immunotherapy	102
A two-phase point-of-care diagnostic device for bladder cancer	100
Targeting vaccines to dendritic cells by mimicking the processing and presentation of antigens in xenotransplant rejection	100
1H magnetic resonance spectroscopic imaging of deuterated glucose and of neurotransmitter metabolism at 7 T in the human brain	97
Reprogramming of fibroblasts into expandable cardiovascular progenitor cells via small molecules in xeno-free conditions	97
A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples	97
A bilingual speech neuroprosthesis driven by cortical articulatory representations shared between languages	96
An off-the-shelf otoacoustic-emission probe for hearing screening via a smartphone	92
A paper-based assay for the colorimetric detection of SARS-CoV-2 variants at single-nucleotide resolution	90
Multiplex imaging of amyloid-β plaques dynamics in living brains with quinoline-malononitrile-based probes	89
Mutation corrections in spinal muscular atrophy	84
Deep screening of antibody–antigen affinities	84
Publisher Correction: Efficient in vivo base editing via single adenoassociated viruses with size-optimized genomes encoding compact adenine base editors	82
Author Correction: Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTENmRNA	82
Mapping tissue heterogeneity in solid tumours using PET–MRI and machine learning	81
Accelerating primer design for amplicon sequencing using large language model-powered agents	80
Eyeing severe diabetes upfront	80
CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers	80
Rapid adaptation of brain–computer interfaces to new neuronal ensembles or participants via generative modelling	80
Isolation of tumour-reactive lymphocytes from peripheral blood via microfluidic immunomagnetic cell sorting	79
Allometrically scaling tissue forces drive pathological foreign-body responses to implants via Rac2-activated myeloid cells	79

A battery-less wireless implant for the continuous monitoring of vascular pressure, flow rate and temperature	79
Straightforward, inexpensive and sensitive	78
Screening for lipid nanoparticles that modulate the immune activity of helper T cells towards enhanced antitumour activity	76
Ablation of FAS confers allogeneic CD3– CAR T cells with resistance to rejection by T cells and natural killer cells	73
Opportunities and challenges in the development of exoskeletons for locomotor assistance	72
A serine-conjugated butyrate prodrug with high oral bioavailability suppresses autoimmune arthritis and neuroinflammation in mice	72
Targeted desialylation and cytolysis of tumour cells by fusing a sialidase to a bispecific T-cell engager	71
Enhancement of the viability of T cells electroporated with DNA via osmotic dampening of the DNA-sensing cGAS–STING pathway	70
Profiling protein–protein interactions to predict the efficacy of B-cell-lymphoma-2-homology-3 mimetics for acute myeloid leukaemia	70
An injectable subcutaneous colon-specific immune niche for the treatment of ulcerative colitis	69
Explaining counterfactual images	68
Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells	68
Insulin independence from stem-cell-derived islets	68
Peptide-mediated delivery of CRISPR enzymes for the efficient editing of primary human lymphocytes	68
Author Correction: Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNA	66
Author Correction: Thermally sentient bionic limbs	66
Osteopontin attenuates the foreign-body response to silicone implants	65
Mineralized bacteria as an immunotherapy agent against various cancer types	65
Antibiotic-mediated selection of randomly mutagenized and cytokine-expressing oncolytic viruses	64
Directed evolution-based discovery of ligands for in vivo restimulation of chimeric antigen receptor T cells	64
Potent prophylactic cancer vaccines harnessing surface antigens shared by tumour cells and induced pluripotent stem cells	63
Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samples	63
Engineering multi-specific nano-antibodies for cancer immunotherapy	63
Concurrently depleting regulatory T cells and activating cytotoxic T cells in tumours	63
Generation of T-cell-receptor-negative CD8αβ-positive CAR T cells from T-cell-derived induced pluripotent stem cells	63
Rational immunosilencing of a promiscuous T-cell epitope in the capsid of an adeno-associated virus	62
Synthetic libraries of immune cells displaying a diverse repertoire of chimaeric antigen receptors as a potent cancer immunotherapy	62
Spatial multi-omics at subcellular resolution via high-throughput in situ pairwise sequencing	61
Addendum: A tissue-engineered scale model of the heart ventricle	61
Opportunities and challenges in cardiac tissue engineering from an analysis of two decades of advances	61
Multi-antigen spherical nucleic acid cancer vaccines	60
Write accessibly	60
Mining for encrypted peptide antibiotics in the human proteome	60
Base editing ablates all protein-coding genes of the mitochondrial genome in mouse cells	60
Publisher Correction: Targeting overexpressed antigens in glioblastoma via CAR T cells with computationally designed high-affinity protein binders	59
Precise virulence inactivation using a CRISPR-associated transposase for combating Enterobacteriaceae gut pathogens	59
Tooling up against mechanobiological orthodoxy	59
Efficient production of non-immunogenic, long circular RNAs for high protein yield	59
A window into solid stresses within tumours	58
Meta-analysis of the make-up and properties of in vitro models of the healthy and diseased blood–brain barrier	57
Biomimetic model to study penile dysfunctions	57
Derivation of prognostic contextual histopathological features from whole-slide images of tumours via graph deep learning	57
Antitumour vaccination via the targeted proteolysis of antigens isolated from tumour lysates	57
Neutrophils bearing adhesive polymer micropatches as a drug-free cancer immunotherapy	56
Antigen-bearing outer membrane vesicles as tumour vaccines produced in situ by ingested genetically engineered bacteria	56
Efficient circular RNA synthesis for potent rolling circle translation	56
Generation of neural organoids for spinal-cord regeneration via the direct reprogramming of human astrocytes	56
Field validation of the performance of paper-based tests for the detection of the Zika and chikungunya viruses in serum samples	55
Towards handy neural prostheses	55
Author Correction: Targeted tumour theranostics in mice via carbon quantum dots structurally mimicking large amino acids	54
How to make cover letters instructive	54
Seeing ageing through retinal images	54
Overcoming immune hurdles to implant longevity	53
Publisher Correction: Non-invasive characterization of pericyte dysfunction in mouse brain using functional ultrasound localization microscopy	53
Identification of druggable regulators of cell secretion via a kinome-wide screen and high-throughput immunomagnetic cell sorting	53
Nutritional deficiency in an intestine-on-a-chip recapitulates injury hallmarks associated with environmental enteric dysfunction	51
Continuous insulin monitoring using an antibody-protecting zwitterionic microneedle patch	51
Rejuvenation of tumour-specific T cells through bispecific antibodies targeting PD-L1 on dendritic cells	50
Fluorescence lifetime of injected indocyanine green as a universal marker of solid tumours in patients	50
Optimization of base editors for the functional correction of SMN2 as a treatment for spinal muscular atrophy	49
DNA-based computation for multiple biomarkers	49
Patterned gastrointestinal monolayers with bilateral access as observable models of parasite gut infection	48
Author Correction: Mannich reaction-based combinatorial libraries identify antioxidant ionizable lipids for mRNA delivery with reduced immunogenicity	48
Lipid nanoparticles for the inhalation of mRNA	48
Designing stable humanized antibodies	47
Mapping and targeted viral activation of pancreatic nerves in mice reveal their roles in the regulation of glucose metabolism	47
Control of the antitumour activity and specificity of CAR T cells via organic adapters covalently tethering the CAR to tumour cells	46
Wirelessly operated bioelectronic sutures for the monitoring of deep surgical wounds	45
Aberrant chromatin reorganization in cells from diseased fibrous connective tissue in response to altered chemomechanical cues	44
Immunization against Zika by entrapping live virus in a subcutaneous self-adjuvanting hydrogel	44
A low-power stretchable neuromorphic nerve with proprioceptive feedback	44
A one-pot isothermal Cas12-based assay for the sensitive detection of microRNAs	44
Contextual learning is nearly all you need	43
Stimulating localizable sensations	43
Targeted knock-ins with pseudovirus for the stable expression of large transgenes	43
Macrophage-augmented organoids recapitulate the complex pathophysiology of viral diseases and enable development of multitarget therapeutics	42
Endocisternal interfaces for minimally invasive neural stimulation and recording of the brain and spinal cord	42
Quantification of intratumoural heterogeneity in mice and patients via machine-learning models trained on PET–MRI data	42
Dynamical flexible inference of nonlinear latent factors and structures in neural population activity	41
Hormonally mediated mechanical remodelling of human haematopoietic stem cells enhances their bone-marrow engraftment	41

A deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases	41
A swallowable X-ray dosimeter	41
Arrayed CRISPR libraries for the genome-wide activation, deletion and silencing of human protein-coding genes	40
Assessing the toxicity of bispecific antibodies	40
Thermoreversibly assembled polymersomes for highly efficient loading, processing and delivery of protein and siRNA biologics	39
Antimicrobial peptides boosted by ultrasound	38
Artificial intelligence advances skull stripping across lifespan	38
Streamlined detection of SARS-CoV-2 via Cas13	37
Elimination of acquired resistance to PD-1 blockade via the concurrent depletion of tumour cells and immunosuppressive cells	37
A swallowable X-ray dosimeter for the real-time monitoring of radiotherapy	37
Clinical validation of a wearable ultrasound sensor of blood pressure	36
Cas9-induced targeted integration of large DNA payloads in primary human T cells via homology-mediated end-joining DNA repair	35
Localized butyrate restores gut homeostasis	35
Label-free intraoperative histology of bone tissue via deep-learning-assisted ultraviolet photoacoustic microscopy	33
Screening oral drugs for their interactions with the intestinal transportome via porcine tissue explants and machine learning	33
Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy	33
A fast all-optical 3D photoacoustic scanner for clinical vascular imaging	33
Dynamic monitoring of thousands of biochemical analytes using microsampling	33
Reinforcement of the intestinal mucosal barrier via mucus-penetrating PEGylated bacteria	33
Making CRISPR more deliverable	33
A thermogalvanic cell dressing for smart wound monitoring and accelerated healing	33
Unconditional latent diffusion models memorize patient imaging data	32
The analgesic potential of heavy water	32
A stealthy neural recorder for the study of behaviour in primates	32
Multiplexed discrimination of SARS-CoV-2 variants via plasmonic-enhanced fluorescence in a portable and automated device	32
A compact, wireless system for continuous monitoring of breast milk expressed during breastfeeding	32
Efficient recovery of potent tumour-infiltrating lymphocytes through quantitative immunomagnetic cell sorting	32
Transthoracic ultrasound localization microscopy of myocardial vasculature in patients	31
Intraoperative imaging in pathology-assisted surgery	31
A wearable electrochemical biosensor for the monitoring of metabolites and nutrients	31
Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	31
A wireless patch for the monitoring of C-reactive protein in sweat	31
Immunogenic amines on lipid nanoparticles	30
Safer and efficient base editing and prime editing via ribonucleoproteins delivered through optimized lipid-nanoparticle formulations	30
CRISPR-GPT for agentic automation of gene-editing experiments	30
Squeezing more out from clinical imaging	29
Bridging scales in brain connectivity	29
Rapid discovery of high-affinity antibodies via massively parallel sequencing, ribosome display and affinity screening	29
Targeting NK2R reverses cardiometabolic dysfunction	29
Sensing the DNA-mismatch tolerance of catalytically inactive Cas9 via barcoded DNA nanostructures in solid-state nanopores	28
Solvent-mediated analgesia via the suppression of water permeation through TRPV1 ion channels	28
Advanced glycation end-products as mediators of the aberrant crosslinking of extracellular matrix in scarred liver tissue	28
Paired CRISPR screening libraries for studying the function of the non-coding genome at scale	28
Gene correction for sickle cell disease hits its prime	28
Expanded toolkits for RNA circularization	28
Holographic transcranial ultrasound neuromodulation enhances stimulation efficacy by cooperatively recruiting distributed brain circuits	27
Urinary bioorthogonal reporters for the monitoring of the efficacy of chemotherapy for lung cancer and of associated kidney injury	27
A generalist model for enhancing brain MRIs	27
Nitroglycerin-responsive gene switch for the on-demand production of therapeutic proteins	26
Genetically engineered and enucleated human mesenchymal stromal cells for the targeted delivery of therapeutics to diseased tissue	26
Activatable near-infrared probes for the detection of specific populations of tumour-infiltrating leukocytes in vivo and in urine	26
Mapping light distribution in the brain via MRI	25
Delivery of local anaesthetics by a self-assembled supramolecular system mimicking their interactions with a sodium channel	25
Advancing breast cancer risk stratification using multimodal AI	25
Conjugation of glucosylated polymer chains to checkpoint blockade antibodies augments their efficacy and specificity for glioblastoma	25
Fast capturing of deep blood flow	24
Self-organization of sinusoidal vessels in pluripotent stem cell-derived human liver bud organoids	24
A deep learning system for detecting silent brain infarction and predicting stroke risk	24
Targeting the PIEZO1 pathway boosts T cell antitumour cytotoxicity	24
Nanoprobes for X-ray-mediated theranostics	24
‘CRISPRing’ with therapeutic cells	24
Author Correction: Organ-specific metastases obtained by culturing colorectal cancer cells on tissue-specific decellularized scaffolds	24
Histopathological biomarkers for predicting the tumour accumulation of nanomedicines	23
Restoration of sensory feedback from the foot and reduction of phantom limb pain via closed-loop spinal cord stimulation	23
AAV-mediated delivery of a Sleeping Beauty transposon and an mRNA-encoded transposase for the engineering of therapeutic immune cells	23
Tackling prediction uncertainty in machine learning for healthcare	23
Panoramic photoacoustic computed tomography with learning-based classification enhances breast lesion characterization	23
High-throughput spatiotemporal monitoring of single-cell secretions via plasmonic microwell arrays	23
Oncolytic mineralized bacteria as potent locally administered immunotherapeutics	23
Suppression of cytokine release syndrome during CAR-T-cell therapy via a subcutaneously injected interleukin-6-adsorbing hydrogel	23
Quantitative imaging of apoptosis following oncolytic virotherapy by magnetic resonance fingerprinting aided by deep learning	23
Spatially resolved in vivo imaging of inflammation-associated mRNA via enzymatic fluorescence amplification in a molecular beacon	22
Closed-loop enhancement and neural decoding of cognitive control in humans	22
A multi-organ chip with matured tissue niches linked by vascular flow	21
Optimization of therapeutic antibodies for reduced self-association and non-specific binding via interpretable machine learning	21
Generation of functionally distinct T-cell populations by altering the viscoelasticity of their extracellular matrix	21
Efficient site-specific integration of large genes in mammalian cells via continuously evolved recombinases and prime editing	21
Diagnosis of paediatric tuberculosis by optically detecting two virulence factors on extracellular vesicles in blood samples	21
A lentiviral vector for the production of T cells with an inducible transgene and a constitutively expressed tumour-targeting receptor	20
The myriad ways to engineer cells	20
Fast volumetric scanning of living tissue	20
An instrument-free, programmable approach for nucleic acid detection	20
Author Correction: A low-power stretchable neuromorphic nerve with proprioceptive feedback	20
Author Correction: An organoid-based screen for epigenetic inhibitors that stimulate antigen presentation and potentiate T-cell-mediated cytotoxicity	20
Pathological mechanosensing	20
Oxonium ion scanning mass spectrometry for large-scale plasma glycoproteomics	20
Mechanical regulation of extracellular vesicle activity during tumour progression	20
Publisher Correction: Compression and amplification algorithms in hearing aids impair the selectivity of neural responses to speech	20
Author Correction: Enhanced control of a brain–computer interface by tetraplegic participants via neural-network-mediated feature extraction	20
Detection of signs of disease in external photographs of the eyes via deep learning	19
Cas12a-knock-in mice for multiplexed genome editing, disease modelling and immune-cell engineering	19
Deep brain stimulation by blood–brain-barrier-crossing piezoelectric nanoparticles generating current and nitric oxide under focused ultrasound	19
Textile-embedded cell-free biosensors	19
Setting morphogen gradients	19
Surgical polarimetric endoscopy for the detection of laryngeal cancer	19