OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Biomedical Engineering is 86. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Data-efficient and weakly supervised computational pathology on whole-slide images	758
The evolution of commercial drug delivery technologies	699
CRISPR-based diagnostics	625
An epidermal patch for the simultaneous monitoring of haemodynamic and metabolic biomarkers	387
A wearable electrochemical biosensor for the monitoring of metabolites and nutrients	367
Pre-symptomatic detection of COVID-19 from smartwatch data	332
Synthetic data in machine learning for medicine and healthcare	325
Rapid single-molecule detection of COVID-19 and MERS antigens via nanobody-functionalized organic electrochemical transistors	271
A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics	265
An integrated wearable microneedle array for the continuous monitoring of multiple biomarkers in interstitial fluid	262
Optimization of lipid nanoparticles for the delivery of nebulized therapeutic mRNA to the lungs	232
Microneedle patch for the ultrasensitive quantification of protein biomarkers in interstitial fluid	221
A multi-organ chip with matured tissue niches linked by vascular flow	218
Rapid lateral flow immunoassay for the fluorescence detection of SARS-CoV-2 RNA	214
Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets	204
A soft neuroprosthetic hand providing simultaneous myoelectric control and tactile feedback	204
Rapid and ultrasensitive electromechanical detection of ions, biomolecules and SARS-CoV-2 RNA in unamplified samples	196
Transcranial ultrafast ultrasound localization microscopy of brain vasculature in patients	193
Accelerated antimicrobial discovery via deep generative models and molecular dynamics simulations	190
Rapid and coagulation-independent haemostatic sealing by a paste inspired by barnacle glue	188
Self-supervised learning in medicine and healthcare	187
Treatment of infarcted heart tissue via the capture and local delivery of circulating exosomes through antibody-conjugated magnetic nanoparticles	184
Prolonged activation of innate immune pathways by a polyvalent STING agonist	184
Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning	182
Enhanced tumour penetration and prolonged circulation in blood of polyzwitterion–drug conjugates with cell-membrane affinity	181

Wireless and battery-free technologies for neuroengineering	178
Fast detection of SARS-CoV-2 RNA via the integration of plasmonic thermocycling and fluorescence detection in a portable device	173
Deep-learning models for the detection and incidence prediction of chronic kidney disease and type 2 diabetes from retinal fundus images	161
A lab-on-a-chip for the concurrent electrochemical detection of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in saliva and plasma	149
Fast and sensitive detection of SARS-CoV-2 RNA using suboptimal protospacer adjacent motifs for Cas12a	148
The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans	145
Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow	143
Continuous monitoring of deep-tissue haemodynamics with stretchable ultrasonic phased arrays	141
Prospective assessment of breast cancer risk from multimodal multiview ultrasound images via clinically applicable deep learning	140
A strain-programmed patch for the healing of diabetic wounds	136
Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine	134
Shifting machine learning for healthcare from development to deployment and from models to data	133
Rapid manufacturing of non-activated potent CAR T cells	132
Open resource of clinical data from patients with pneumonia for the prediction of COVID-19 outcomes via deep learning	132
Toward higher-performance bionic limbs for wider clinical use	132
Restoration of sensory information via bionic hands	131
Cryomicroneedles for transdermal cell delivery	130
Transdermal microneedles for the programmable burst release of multiple vaccine payloads	129
A soft and transparent contact lens for the wireless quantitative monitoring of intraocular pressure	128
Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel	125
Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity	124
A portable scanner for magnetic resonance imaging of the brain	121
Tether-free photothermal deep-brain stimulation in freely behaving mice via wide-field illumination in the near-infrared-II window	119
A deep-learning pipeline for the diagnosis and discrimination of viral, non-viral and COVID-19 pneumonia from chest X-ray images	118
Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance	118
A paper-based assay for the colorimetric detection of SARS-CoV-2 variants at single-nucleotide resolution	116
Massively parallel functional photoacoustic computed tomography of the human brain	115
Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy	114
Exosome-eluting stents for vascular healing after ischaemic injury	114
Injectable and conductive cardiac patches repair infarcted myocardium in rats and minipigs	113
Limitations and opportunities of technologies for the analysis of cell-free DNA in cancer diagnostics	113
Expert-level detection of pathologies from unannotated chest X-ray images via self-supervised learning	113
Lentiviral delivery of co-packaged Cas9 mRNA and a Vegfa-targeting guide RNA prevents wet age-related macular degeneration in mice	111
A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves	110
Control of the activity of CAR-T cells within tumours via focused ultrasound	110
Nanoparticles with ultrasound-induced afterglow luminescence for tumour-specific theranostics	110
An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma	108
Fungal brain infection modelled in a human-neurovascular-unit-on-a-chip with a functional blood–brain barrier	105
Simplified Cas13-based assays for the fast identification of SARS-CoV-2 and its variants	104
Antigen-bearing outer membrane vesicles as tumour vaccines produced in situ by ingested genetically engineered bacteria	102
Systemic immune responses to irradiated tumours via the transport of antigens to the tumour periphery by injected flagellate bacteria	101
Biomimetic cartilage-lubricating polymers regenerate cartilage in rats with early osteoarthritis	101
Application of prime editing to the correction of mutations and phenotypes in adult mice with liver and eye diseases	100
Performance benchmarking of microbubble-localization algorithms for ultrasound localization microscopy	100
Modelling and prediction of the dynamic responses of large-scale brain networks during direct electrical stimulation	99
T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours	99
Algorithmic fairness in artificial intelligence for medicine and healthcare	97
Neutralizing antibodies for the treatment of COVID-19	96
Generation of hypoimmunogenic T cells from genetically engineered allogeneic human induced pluripotent stem cells	94
A one-pot isothermal Cas12-based assay for the sensitive detection of microRNAs	93

Harnessing non-destructive 3D pathology	93
Graph representation learning in biomedicine and healthcare	92
Discrimination of single-point mutations in unamplified genomic DNA via Cas9 immobilized on a graphene field-effect transistor	92
Detection of ovarian cancer via the spectral fingerprinting of quantum-defect-modified carbon nanotubes in serum by machine learning	91
Opportunities and challenges in the diagnostic utility of dermal interstitial fluid	91
A phosphorescent probe for in vivo imaging in the second near-infrared window	91
Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts	90
Ultrasensitive detection of circulating tumour DNA via deep methylation sequencing aided by machine learning	89
A wireless patch for the monitoring of C-reactive protein in sweat	89
A low-power stretchable neuromorphic nerve with proprioceptive feedback	88
Enhanced intratumoural activity of CAR T cells engineered to produce immunomodulators under photothermal control	87
Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors	86