OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Biomedical Engineering is 76. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Sensitive detection of SARS-CoV-2 on paper	771
Author Correction: Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation	539
An implantable hydrogel-based phononic crystal for continuous and wireless monitoring of internal tissue strains	527
A data-efficient strategy for building high-performing medical foundation models	504
Rapid and stain-free quantification of viral plaque via lens-free holography and deep learning	353
Deep mutational learning for the selection of therapeutic antibodies resistant to the evolution of Omicron variants of SARS-CoV-2	353
Human gastric multi-regional assembloids for functional parietal maturation and patient-specific modelling of antral foveolar hyperplasia	330
A strain-programmed patch for the healing of diabetic wounds	307
A nanoparticle probe for the imaging of autophagic flux in live mice via magnetic resonance and near-infrared fluorescence	298
A humanized minipig model for the toxicological testing of therapeutic recombinant antibodies	295
Brain–heart–eye axis revealed by multi-organ imaging genetics and proteomics	276
Single-nucleus transcriptomics of an engineered pig model reveals microglia–T cell interactions driving Huntington’s disease neurodegeneration	266
Neuroimaging endophenotypes reveal underlying mechanisms and genetic factors contributing to progression and development of four brain disorders	243
Perilesional neuromodulation replaces lost sensorimotor function in persons with spinal cord injury	238
Emergency delivery of particulate drugs by active ejection using in vivo wireless devices	234
Synaptic connectivity mapping among thousands of neurons via parallelized intracellular recording with a microhole electrode array	226
Low-input deep learning platform for citrullinated peptide identification, autoantigen discovery and rheumatoid arthritis treatment stratification	220
FAS-less allogeneic CAR T cells	219
Streamlining point-of-care assays	206
Autonomous ultrasound with UltraBot	205
Publisher Correction: Restoration of sensory feedback from the foot and reduction of phantom limb pain via closed-loop spinal cord stimulation	198
Author Correction: Endocisternal interfaces for minimally invasive neural stimulation and recording of the brain and spinal cord	196
Systematic functional screening of switchable aptamer beacon probes	189
A generative model uses healthy and diseased image pairs for pixel-level chest X-ray pathology localization	178
Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation	173

Three-dimensional architecture of human bone marrow	164
Unbiased discovery of autoantibodies associated with severe COVID-19 via genome-scale self-assembled DNA-barcoded protein libraries	163
A sonosensitive diphenylalanine-based broad-spectrum antimicrobial peptide	153
Downregulating human leucocyte antigens on mesenchymal stromal cells by epigenetically repressing a β2-microglobulin super-enhancer	149
Ultrasensitive and long-lasting bioluminescence immunoassay for point-of-care viral antigen detection	149
Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington’s disease	148
A high-density microfluidic bioreactor for the automated manufacturing of CAR T cells	143
Large DNA deletions occur during DNA repair at 20-fold lower frequency for base editors and prime editors than for Cas9 nucleases	142
Faster detection of somatic structural variants	140
Generation of antigen-specific mature T cells from RAG1−/−RAG2−/−B2M−/− stem cells by engineering their microenvironment	138
A warm introduction	133
Offbeat drug-delivery tactics	132
Engineered non-expansive matrix for blood vessel organoid development and ischaemic stroke repair	130
Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions	129
Probing when dCas9 tolerates DNA mismatches	126
Fluid shear stress activates a targetable mechano-metastatic cascade to promote medulloblastoma metastasis	123
Engineered allogeneic T cells decoupling T-cell-receptor and CD3 signalling enhance the antitumour activity of bispecific antibodies	123
Anchored random reverse primer sequencing for quantitative detection of novel gene fusions	123
LDL-binding IL-10 reduces vascular inflammation in atherosclerotic mice	118
Publisher Correction: Large-scale generation of iNK and CAR-iNK cells from CD34+ haematopoietic stem and progenitor cells for adoptive immunotherapy	118
A filamentary soft robotic probe for multimodal in utero monitoring of fetal health	118
A base editor for the long-term restoration of auditory function in mice with recessive profound deafness	117
Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker	116
Immune-privileged tissues formed from immunologically cloaked mouse embryonic stem cells survive long term in allogeneic hosts	112
Prevention and treatment of peri-implant fibrosis by functionally inhibiting skeletal cells expressing the leptin receptor	108
A deep-learning model for quantifying circulating tumour DNA from the density distribution of DNA-fragment lengths	107
Targeting inflammation with chimeric antigen receptor macrophages using a signal switch	104
Potentiating cancer immunotherapies with modular albumin-hitchhiking nanobody–STING agonist conjugates	102
A knockout run for CRISPRed cells	100
A two-phase point-of-care diagnostic device for bladder cancer	97
Sensing haemodynamics via wearables in sync	95
Subcutaneous pancreatic islet transplantation without immunosuppression	93
A deep learning and large language hybrid workflow for omics interpretation	92
X-ray activated platinum complex induces DNA damage and enhances cancer immunotherapy through abscopal effect	88
A bilingual speech neuroprosthesis driven by cortical articulatory representations shared between languages	87
Shape-conformal porous frameworks for full coverage of neural organoids and high-resolution electrophysiology	86
Making MRI increasingly useful	85
1H magnetic resonance spectroscopic imaging of deuterated glucose and of neurotransmitter metabolism at 7 T in the human brain	85
mRNA delivery to the endometrium	84
A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples	84
A three-dimensional multi-modal foundation model for optical coherence tomography	82
Mapping light distribution in tissue by using MRI-detectable photosensitive liposomes	82
An off-the-shelf otoacoustic-emission probe for hearing screening via a smartphone	81
A paper-based assay for the colorimetric detection of SARS-CoV-2 variants at single-nucleotide resolution	81
Multiplex imaging of amyloid-β plaques dynamics in living brains with quinoline-malononitrile-based probes	79
Targeting vaccines to dendritic cells by mimicking the processing and presentation of antigens in xenotransplant rejection	79
Nanobody-based bispecific antibody engagers targeting CTLA-4 or PD-L1 for cancer immunotherapy	79
Challenges and opportunities of acquiring cortical recordings for chronic adaptive deep brain stimulation	79
Mapping tissue heterogeneity in solid tumours using PET–MRI and machine learning	78
Mutation corrections in spinal muscular atrophy	77

Publisher Correction: Efficient in vivo base editing via single adenoassociated viruses with size-optimized genomes encoding compact adenine base editors	76
Engineered thoracic spinal cord organoids for transplantation after spinal cord injury	76
Deep screening of antibody–antigen affinities	76
Where the nanocarriers go	76