OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Biomedical Engineering is 83. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Base editing ablates all protein-coding genes of the mitochondrial genome in mouse cells	876
Arming T cells to infiltrate pancreatic tumours	790
Sutures for the wireless sensing of deep wounds	692
Efficient circular RNA synthesis for potent rolling circle translation	396
A base editor for correcting deafness	395
Author Correction: Enhanced control of a brain–computer interface by tetraplegic participants via neural-network-mediated feature extraction	374
A soft robotic sleeve mimicking the haemodynamics and biomechanics of left ventricular pressure overload and aortic stenosis	303
Robust and data-efficient generalization of self-supervised machine learning for diagnostic imaging	286
Rapid and stain-free quantification of viral plaque via lens-free holography and deep learning	285
Induction of antigen-specific tolerance by nanobody–antigen adducts that target class-II major histocompatibility complexes	258
Lasso-grafted designer cytokines	244
Rational vaccinology maximizes the efficacy of multi-antigen vaccines	222
Fast volumetric scanning of living tissue	219
Erythrocyte-mediated systemic immunotherapy	217
Textile-embedded cell-free biosensors	215
An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma	204
MRI of transmembrane water efflux in gliomas	204
Derivation of prognostic contextual histopathological features from whole-slide images of tumours via graph deep learning	201
An engineered live biotherapeutic for the prevention of antibiotic-induced dysbiosis	200
A lentiviral vector for the production of T cells with an inducible transgene and a constitutively expressed tumour-targeting receptor	195
Prevention of vascular-allograft rejection by protecting the endothelial glycocalyx with immunosuppressive polymers	193
Generation of synthetic whole-slide image tiles of tumours from RNA-sequencing data via cascaded diffusion models	182
A window into solid stresses within tumours	173
Glycation-driven matrix crosslinking in cirrhosis	170
Affordable hearing screening	166

Oxonium ion scanning mass spectrometry for large-scale plasma glycoproteomics	166
Affinity maturation of CRISPR-engineered B cell receptors in vivo	160
The myriad ways to engineer cells	159
Engineering cell-derived extracellular vesicles for gene therapy	158
Intravascularly infused extracellular matrix as a biomaterial for targeting and treating inflamed tissues	150
Retinal detection of kidney disease and diabetes	149
Tooling up against mechanobiological orthodoxy	143
Hail the AI journal editor	141
Write accessibly	141
Sealing the heart from the inside out	140
How to appeal well	133
Potentiating cancer immunotherapies	132
Pathological mechanosensing	129
An instrument-free, programmable approach for nucleic acid detection	128
Contactless optical coherence tomography of the eyes of freestanding individuals with a robotic scanner	127
Non-invasive monitoring of autophagy	127
Multiplexed transcriptomic profiling of the fate of human CAR T cells in vivo via genetic barcoding with shielded small nucleotides	126
Deep mutational scanning and machine learning for the analysis of antimicrobial-peptide features driving membrane selectivity	126
PEGylated bacteria penetrate mucus and strengthen the gut mucosal barrier	123
Efficient production of non-immunogenic, long circular RNAs for high protein yield	123
Leucine zipper-based immunomagnetic purification of CAR T cells displaying multiple receptors	122
Wireless and battery-free technologies for neuroengineering	119
Publisher Correction: Targeting overexpressed antigens in glioblastoma via CAR T cells with computationally designed high-affinity protein binders	118
Computational design of protein binders that boost the antitumour efficacy of CAR T cells	118
Evolving virus-like particles	113
Enhancement of erythropoietic output by Cas9-mediated insertion of a natural variant in haematopoietic stem and progenitor cells	112
A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics	111
Prediction of the cell-type-specific transcription of non-coding RNAs from genome sequences via machine learning	111
The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans	111
‘Hit and run’ therapy averts macular degeneration	110
A humanized minipig model for the toxicological testing of therapeutic recombinant antibodies	110
A library of base editors for the precise ablation of all protein-coding genes in the mouse mitochondrial genome	110
A soft and transparent contact lens for the wireless quantitative monitoring of intraocular pressure	108
Generation of neural organoids for spinal-cord regeneration via the direct reprogramming of human astrocytes	108
Sensitive detection of SARS-CoV-2 on paper	104
Brachytherapy via a depot of biopolymer-bound 131I synergizes with nanoparticle paclitaxel in therapy-resistant pancreatic tumours	103
Assessment of visual function in blind mice and monkeys with subretinally implanted nanowire arrays as artificial photoreceptors	101
Detection of cellular traction forces via the force-triggered Cas12a-mediated catalytic cleavage of a fluorogenic reporter strand	100
Field validation of the performance of paper-based tests for the detection of the Zika and chikungunya viruses in serum samples	100
Exosome-eluting stents for vascular healing after ischaemic injury	99
A deep-learning model for transforming the style of tissue images from cryosectioned to formalin-fixed and paraffin-embedded	99
Stable expression of large transgenes via the knock-in of an integrase-deficient lentivirus	97
Systemic immune responses to irradiated tumours via the transport of antigens to the tumour periphery by injected flagellate bacteria	97
A strain-programmed patch for the healing of diabetic wounds	93
Enhanced engraftment of human haematopoietic stem cells via mechanical remodelling mediated by the corticotropin-releasing hormone	92
Solid stress impairs lymphocyte infiltration into lymph-node metastases	92
Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance	92
Neutrophils bearing adhesive polymer micropatches as a drug-free cancer immunotherapy	91
Posterior scleral birefringence measured by triple-input polarization-sensitive imaging as a biomarker of myopia progression	91
Mesenchymal stromal cells with chimaeric antigen receptors for enhanced immunosuppression	90

Miniaturized implantable temperature sensors for the long-term monitoring of chronic intestinal inflammation	90
A lab-on-a-chip for the concurrent electrochemical detection of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in saliva and plasma	89
Variants of the adeno-associated virus serotype 9 with enhanced penetration of the blood–brain barrier in rodents and primates	88
Characterization of the responses of brain macrophages to focused ultrasound-mediated blood–brain barrier opening	88
Generation of hypoimmunogenic T cells from genetically engineered allogeneic human induced pluripotent stem cells	87
Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine	87
Shear-stress sensing by PIEZO1 regulates tendon stiffness in rodents and influences jumping performance in humans	84
Deep brain stimulation by blood–brain-barrier-crossing piezoelectric nanoparticles generating current and nitric oxide under focused ultrasound	84