OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Biomedical Engineering is 75. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Sensitive detection of SARS-CoV-2 on paper	834
Author Correction: Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation	648
Perilesional neuromodulation replaces lost sensorimotor function in persons with spinal cord injury	539
Human gastric multi-regional assembloids for functional parietal maturation and patient-specific modelling of antral foveolar hyperplasia	404
Emergency delivery of particulate drugs by active ejection using in vivo wireless devices	364
Brain–heart–eye axis revealed by multi-organ imaging genetics and proteomics	335
Single-nucleus transcriptomics of an engineered pig model reveals microglia–T cell interactions driving Huntington’s disease neurodegeneration	333
Synaptic connectivity mapping among thousands of neurons via parallelized intracellular recording with a microhole electrode array	305
Nanosensor-integrated catheters for chemical mapping of bladder cancer biomarkers	281
A humanized minipig model for the toxicological testing of therapeutic recombinant antibodies	258
RModBlock antisense oligonucleotides as a universal tool for precise and efficient inhibition of RNA modifications	251
Deep mutational learning for the selection of therapeutic antibodies resistant to the evolution of Omicron variants of SARS-CoV-2	248
Rapid and stain-free quantification of viral plaque via lens-free holography and deep learning	241
An implantable hydrogel-based phononic crystal for continuous and wireless monitoring of internal tissue strains	237
Neuroimaging endophenotypes reveal underlying mechanisms and genetic factors contributing to progression and development of four brain disorders	229
A data-efficient strategy for building high-performing medical foundation models	208
FAS-less allogeneic CAR T cells	189
Streamlining point-of-care assays	188
Three-dimensional architecture of human bone marrow	185
Autonomous ultrasound with UltraBot	170
Author Correction: Endocisternal interfaces for minimally invasive neural stimulation and recording of the brain and spinal cord	169
Publisher Correction: Restoration of sensory feedback from the foot and reduction of phantom limb pain via closed-loop spinal cord stimulation	167
Downregulating human leucocyte antigens on mesenchymal stromal cells by epigenetically repressing a β2-microglobulin super-enhancer	165
From breadth to depth in clinical artificial intelligence evaluation	164
Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington’s disease	159

A generative model uses healthy and diseased image pairs for pixel-level chest X-ray pathology localization	158
Ultrasensitive and long-lasting bioluminescence immunoassay for point-of-care viral antigen detection	158
A high-density microfluidic bioreactor for the automated manufacturing of CAR T cells	150
Unbiased discovery of autoantibodies associated with severe COVID-19 via genome-scale self-assembled DNA-barcoded protein libraries	149
Machine learning-guided design of mechanoadaptive bioglues for multitissue trauma and first-aid applications	146
Real-time single-particle imaging of functional lungs reveals mosaic-like patterns of aerosol deposition in alveoli	142
Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation	140
Low-input deep learning platform for citrullinated peptide identification, autoantigen discovery and rheumatoid arthritis treatment stratification	136
Large DNA deletions occur during DNA repair at 20-fold lower frequency for base editors and prime editors than for Cas9 nucleases	132
A sonosensitive diphenylalanine-based broad-spectrum antimicrobial peptide	131
Systematic functional screening of switchable aptamer beacon probes	131
Prevention and treatment of peri-implant fibrosis by functionally inhibiting skeletal cells expressing the leptin receptor	127
A filamentary soft robotic probe for multimodal in utero monitoring of fetal health	127
Generation of antigen-specific mature T cells from RAG1−/−RAG2−/−B2M−/− stem cells by engineering their microenvironment	126
A warm introduction	124
Offbeat drug-delivery tactics	119
Anchored random reverse primer sequencing for quantitative detection of novel gene fusions	116
Engineered non-expansive matrix for blood vessel organoid development and ischaemic stroke repair	116
Probing when dCas9 tolerates DNA mismatches	113
LDL-binding IL-10 reduces vascular inflammation in atherosclerotic mice	110
Publisher Correction: Large-scale generation of iNK and CAR-iNK cells from CD34+ haematopoietic stem and progenitor cells for adoptive immunotherapy	110
Faster detection of somatic structural variants	104
A base editor for the long-term restoration of auditory function in mice with recessive profound deafness	104
A deep-learning model for quantifying circulating tumour DNA from the density distribution of DNA-fragment lengths	104
Engineered allogeneic T cells decoupling T-cell-receptor and CD3 signalling enhance the antitumour activity of bispecific antibodies	104
Targeting inflammation with chimeric antigen receptor macrophages using a signal switch	101
Fluid shear stress activates a targetable mechano-metastatic cascade to promote medulloblastoma metastasis	97
Potentiating cancer immunotherapies with modular albumin-hitchhiking nanobody–STING agonist conjugates	97
Towards generalizable AI in medicine via Generalist–Specialist Collaboration	96
Immune-privileged tissues formed from immunologically cloaked mouse embryonic stem cells survive long term in allogeneic hosts	92
Engineering challenges and translational opportunities in emerging gene delivery platforms	91
Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions	91
Sensing haemodynamics via wearables in sync	90
A two-phase point-of-care diagnostic device for bladder cancer	90
A knockout run for CRISPRed cells	90
A deep learning and large language hybrid workflow for omics interpretation	87
Subcutaneous pancreatic islet transplantation without immunosuppression	87
A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples	86
mRNA delivery to the endometrium	85
Making MRI increasingly useful	85
Breathing life into digital twins	83
An off-the-shelf otoacoustic-emission probe for hearing screening via a smartphone	83
Shape-conformal porous frameworks for full coverage of neural organoids and high-resolution electrophysiology	82
A three-dimensional multi-modal foundation model for optical coherence tomography	82
Author Correction: Implanted microelectrode arrays in reinnervated muscles allow separation of neural drives from transferred polyfunctional nerves	81
A bilingual speech neuroprosthesis driven by cortical articulatory representations shared between languages	80
Nanobody-based bispecific antibody engagers targeting CTLA-4 or PD-L1 for cancer immunotherapy	80
Multiplex imaging of amyloid-β plaques dynamics in living brains with quinoline-malononitrile-based probes	80
Mapping light distribution in tissue by using MRI-detectable photosensitive liposomes	80
1H magnetic resonance spectroscopic imaging of deuterated glucose and of neurotransmitter metabolism at 7 T in the human brain	79

Challenges and opportunities of acquiring cortical recordings for chronic adaptive deep brain stimulation