OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Biomedical Engineering is 89. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Base editing ablates all protein-coding genes of the mitochondrial genome in mouse cells	905
Arming T cells to infiltrate pancreatic tumours	792
Author Correction: Enhanced control of a brain–computer interface by tetraplegic participants via neural-network-mediated feature extraction	492
A data-efficient strategy for building high-performing medical foundation models	412
Non-viral intron knock-ins for targeted gene integration into human T cells and for T-cell selection	344
3D-printed perfused models of the penis for the study of penile physiology and for restoring erectile function in rabbits and pigs	312
Deep mutational learning for the selection of therapeutic antibodies resistant to the evolution of Omicron variants of SARS-CoV-2	306
Induction of antigen-specific tolerance by nanobody–antigen adducts that target class-II major histocompatibility complexes	295
Prevention of vascular-allograft rejection by protecting the endothelial glycocalyx with immunosuppressive polymers	279
Stable expression of large transgenes via the knock-in of an integrase-deficient lentivirus	270
A humanized minipig model for the toxicological testing of therapeutic recombinant antibodies	264
A strain-programmed patch for the healing of diabetic wounds	242
Rational vaccinology maximizes the efficacy of multi-antigen vaccines	240
MRI of transmembrane water efflux in gliomas	237
A lentiviral vector for the production of T cells with an inducible transgene and a constitutively expressed tumour-targeting receptor	223
A soft robotic sleeve mimicking the haemodynamics and biomechanics of left ventricular pressure overload and aortic stenosis	222
Generation of synthetic whole-slide image tiles of tumours from RNA-sequencing data via cascaded diffusion models	214
Enhanced control of a brain–computer interface by tetraplegic participants via neural-network-mediated feature extraction	209
Potentiating cancer immunotherapies	197
A window into solid stresses within tumours	195
Glycation-driven matrix crosslinking in cirrhosis	189
The myriad ways to engineer cells	187
Engineering cell-derived extracellular vesicles for gene therapy	187
Enhancement of erythropoietic output by Cas9-mediated insertion of a natural variant in haematopoietic stem and progenitor cells	180
Derivation of prognostic contextual histopathological features from whole-slide images of tumours via graph deep learning	175

Tooling up against mechanobiological orthodoxy	174
Hail the AI journal editor	173
Write accessibly	172
How to appeal well	170
Synaptic connectivity mapping among thousands of neurons via parallelized intracellular recording with a microhole electrode array	167
Pathological mechanosensing	163
Charting targeted courses for vaccination	163
High-throughput screening of genetic and cellular drivers of syncytium formation induced by the spike protein of SARS-CoV-2	162
Sutures for the wireless sensing of deep wounds	161
Publisher Correction: Compression and amplification algorithms in hearing aids impair the selectivity of neural responses to speech	160
Author Correction: A low-power stretchable neuromorphic nerve with proprioceptive feedback	160
Non-invasive monitoring of autophagy	157
Affinity maturation of CRISPR-engineered B cell receptors in vivo	155
Author Correction: Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation	153
Affordable hearing screening	148
Sealing the heart from the inside out	148
Lasso-grafted designer cytokines	148
Prediction of the cell-type-specific transcription of non-coding RNAs from genome sequences via machine learning	146
Multiplexed transcriptomic profiling of the fate of human CAR T cells in vivo via genetic barcoding with shielded small nucleotides	144
Author Correction: An organoid-based screen for epigenetic inhibitors that stimulate antigen presentation and potentiate T-cell-mediated cytotoxicity	140
Author Correction: Blood–brain barrier injury and neuroinflammation induced by SARS-CoV-2 in a lung–brain microphysiological system	139
Author Correction: Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans	139
Detection of cellular traction forces via the force-triggered Cas12a-mediated catalytic cleavage of a fluorogenic reporter strand	138
Publisher Correction: Targeting overexpressed antigens in glioblastoma via CAR T cells with computationally designed high-affinity protein binders	137
Meta-analysis of the make-up and properties of in vitro models of the healthy and diseased blood–brain barrier	137
Leucine zipper-based immunomagnetic purification of CAR T cells displaying multiple receptors	137
Author Correction: Prolonged activation of innate immune pathways by a polyvalent STING agonist	131
Retinal detection of kidney disease and diabetes	129
Textile-embedded cell-free biosensors	127
Erythrocyte-mediated systemic immunotherapy	127
Author Correction: Ultrasensitive detection of circulating tumour DNA via deep methylation sequencing aided by machine learning	127
Fast volumetric scanning of living tissue	126
Field validation of the performance of paper-based tests for the detection of the Zika and chikungunya viruses in serum samples	126
A base editor for correcting deafness	121
Antitumour vaccination via the targeted proteolysis of antigens isolated from tumour lysates	121
Enhanced engraftment of human haematopoietic stem cells via mechanical remodelling mediated by the corticotropin-releasing hormone	119
PEGylated bacteria penetrate mucus and strengthen the gut mucosal barrier	118
Deep mutational scanning and machine learning for the analysis of antimicrobial-peptide features driving membrane selectivity	118
Efficient production of non-immunogenic, long circular RNAs for high protein yield	117
Computational design of protein binders that boost the antitumour efficacy of CAR T cells	116
Evolving virus-like particles	114
Cas12a-knock-in mice for multiplexed genome editing, disease modelling and immune-cell engineering	114
Detection of signs of disease in external photographs of the eyes via deep learning	112
Setting morphogen gradients	110
A nanoparticle probe for the imaging of autophagic flux in live mice via magnetic resonance and near-infrared fluorescence	110
Characterization of the responses of brain macrophages to focused ultrasound-mediated blood–brain barrier opening	109
Mesenchymal stromal cells with chimaeric antigen receptors for enhanced immunosuppression	107
Sensitive detection of SARS-CoV-2 on paper	105
Intravascularly infused extracellular matrix as a biomaterial for targeting and treating inflamed tissues	102
A library of base editors for the precise ablation of all protein-coding genes in the mouse mitochondrial genome	102

Rapid and stain-free quantification of viral plaque via lens-free holography and deep learning	102
An instrument-free, programmable approach for nucleic acid detection	97
An engineered live biotherapeutic for the prevention of antibiotic-induced dysbiosis	97
An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma	97
Miniaturized implantable temperature sensors for the long-term monitoring of chronic intestinal inflammation	96
A deep-learning model for transforming the style of tissue images from cryosectioned to formalin-fixed and paraffin-embedded	95
Variants of the adeno-associated virus serotype 9 with enhanced penetration of the blood–brain barrier in rodents and primates	94
Assessment of visual function in blind mice and monkeys with subretinally implanted nanowire arrays as artificial photoreceptors	93
Efficient circular RNA synthesis for potent rolling circle translation	91
Heterogeneity-driven phenotypic plasticity and treatment response in branched-organoid models of pancreatic ductal adenocarcinoma	91
Soft and stretchable organic bioelectronics for continuous intraoperative neurophysiological monitoring during microsurgery	90
Metabolic and immunomodulatory control of type 1 diabetes via orally delivered bile-acid-polymer nanocarriers of insulin or rapamycin	90
Solid stress impairs lymphocyte infiltration into lymph-node metastases	90
Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance	89