Stem Cells Translational Medicine

Article	Citations
Umbilical cord mesenchymal stem cells for COVID-19 acute respiratory distress syndrome: A double-blind, phase 1/2a, randomized controlled trial	269
Intranasal delivery of mesenchymal stem cell-derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's disease	125
The emerging antioxidant paradigm of mesenchymal stem cell therapy	111
Umbilical Cord Mesenchymal Stromal Cells as Critical COVID-19 Adjuvant Therapy: A Randomized Controlled Trial	104
Cell-based therapy to reduce mortality from COVID-19: Systematic review and meta-analysis of human studies on acute respiratory distress syndrome	76
Improved MSC Minimal Criteria to Maximize Patient Safety: A Call to Embrace Tissue Factor and Hemocompatibility Assessment of MSC Products	74
The leading edge: Emerging neuroprotective and neuroregenerative cell-based therapies for spinal cord injury	73
Mesenchymal Stem/Stromal Cell Senescence: Hallmarks, Mechanisms, and Combating Strategies	66
Alveolar wars: The rise of in vitro models to understand human lung alveolar maintenance, regeneration, and disease	64
Current status of mesenchymal stem cell therapy for immune/inflammatory lung disorders: Gleaning insights for possible use in COVID-19	62
Stem Cells for Bronchopulmonary Dysplasia in Preterm Infants: A Randomized Controlled Phase II Trial	55
Advances in Mesenchymal Stem Cell Therapy for Immune and Inflammatory Diseases: Use of Cell-Free Products and Human pluripotent Stem Cell-Derived Mesenchymal Stem Cells	51
Human bone marrow stem/stromal cell osteogenesis is regulated via mechanically activated osteocyte-derived extracellular vesicles	50
High Density Bioprocessing of Human Pluripotent Stem Cells by Metabolic Control and in Silico Modeling	49
The effects of microgravity on differentiation and cell growth in stem cells and cancer stem cells	49
Amniotic membrane-mesenchymal stromal cells secreted factors and extracellular vesicle-miRNAs: Anti-inflammatory and regenerative features for musculoskeletal tissues	45
Hematopoietic stem cells from pluripotent stem cells: Clinical potential, challenges, and future perspectives	43
Treatment of chronic GvHD with mesenchymal stromal cells induces durable responses: A phase II study	42
Resident Interstitial Lung Fibroblasts and their Role in Alveolar Stem Cell Niche Development, Homeostasis, Injury, and Regeneration	42
A randomized, double-blind, vehicle-controlled clinical study of hair regeneration using adipose-derived stem cell constituent extract in androgenetic alopecia	41
The rationale of using mesenchymal stem cells in patients with COVID-19-related acute respiratory distress syndrome: What to expect	41
Amniotic MSCs reduce pulmonary fibrosis by hampering lung B-cell recruitment, retention, and maturation	40
Reemergence of neural crest stem cell-like states in melanoma during disease progression and treatment	39
Infusion of human umbilical cord tissue mesenchymal stromal cells in children with autism spectrum disorder	39
Mesenchymal stem cells as a multimodal treatment for nervous system diseases	38

Mesenchymal stromal cells pretreated with pro-inflammatory cytokines promote skin wound healing through VEGFC-mediated angiogenesis	38
Optimized serial expansion of human induced pluripotent stem cells using low-density inoculation to generate clinically relevant quantities in vertical-wheel bioreactors	38
Cotransplantation of mesenchymal stem cells and endothelial progenitor cells for treating steroid-induced osteonecrosis of the femoral head	37
Ex vivo-expanded autologous adipose tissue-derived stromal cells ensure enhanced fat graft retention in breast augmentation: A randomized controlled clinical trial	37
Brain-derived neurotropic factor mediates neuroprotection of mesenchymal stem cell-derived extracellular vesicles against severe intraventricular hemorrhage in newborn rats	35
Human mesenchymal stromal cells do not express ACE2 and TMPRSS2 and are not permissive to SARS-CoV-2 infection	35
Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of age-related macular degeneration by restoring lysosomal function	33
Treatment of Chronic Diabetic Foot Ulcers with Adipose-Derived Stromal Vascular Fraction Cell Injections: Safety and Evidence of Efficacy at 1 Year	31
Nerve growth factor (NGF) and NGF receptors in mesenchymal stem/stromal cells: Impact on potential therapies	30
Exosomes derived from P2X7 receptor gene-modified cells rescue inflammation-compromised periodontal ligament stem cells from dysfunction	30
Current Concepts on Endothelial Stem Cells Definition, Location, and Markers	30
Neuroprotective effects of human amniotic fluid stem cells-derived secretome in an ischemia/reperfusion model	30
Grafted human pluripotent stem cell-derived cortical neurons integrate into adult human cortical neural circuitry	29
Combination product of dermal matrix, human mesenchymal stem cells, and timolol promotes diabetic wound healing in mice	29
Mesenchymal stem cells as a potential treatment for critically ill patients with coronavirus disease 2019	29
In the eye of the storm: SARS‐CoV‐2 infection and replication at the ocular surface?	28
Lithium modulates miR-1906 levels of mesenchymal stem cell-derived extracellular vesicles contributing to poststroke neuroprotection by toll-like receptor 4 regulation	28
Regulatory considerations for developing a phase I investigational new drug application for autologous induced pluripotent stem cells-based therapy product	27
Cross talk between mesenchymal and glioblastoma stem cells: Communication beyond controversies	27
Umbilical Cord Blood Transplantation: Still Growing and Improving	27
Development of an optimized and scalable method for isolation of umbilical cord blood-derived small extracellular vesicles for future clinical use	26
Cross-matching of allogeneic mesenchymal stromal cells eliminates recipient immune targeting	26
Human induced pluripotent stem cell-derived lung organoids in an ex vivo model of the congenital diaphragmatic hernia fetal lung	26
Role of Extracellular Vesicles from Adipose Tissue- and Bone Marrow-Mesenchymal Stromal Cells in Endothelial Proliferation and Chondrogenesis	25
Umbilical cord blood: The promise and the uncertainty	25
Precision installation of a highly efficient suicide gene safety switch in human induced pluripotent stem cells	25
Type 2 Diabetes Mellitus Duration and Obesity alter the Efficacy of Autologously Transplanted Bone Marrow-derived Mesenchymal Stem/Stromal Cells	25
Outcomes of bone marrow mononuclear cell transplantation combined with interventional education for autism spectrum disorder	24
The novel long noncoding RNA lncRNA-Adi regulates adipogenesis	24
Human mesenchymal stromal cells and derived extracellular vesicles: Translational strategies to increase their proangiogenic potential for the treatment of cardiovascular disease	24
Prospect of stem cells conditioned medium (secretome) in ligament and tendon healing: A systematic review	23
Donor genetic backgrounds contribute to the functional heterogeneity of stem cells and clinical outcomes	23
Molecular investigation of adequate sources of mesenchymal stem cells for cell therapy of COVID-19-associated organ failure	23
Hematopoietic Stem Cell- and Induced Pluripotent Stem Cell-Derived CAR-NK Cells as Reliable Cell-Based Therapy Solutions	22
Updated Living Systematic Review and Meta-analysis of Controlled Trials of Mesenchymal Stromal Cells to Treat COVID-19: A Framework for Accelerated Synthesis of Trial Evidence for Rapid Approval—FASTE	21
METTL14 Regulates Osteogenesis of Bone Marrow Mesenchymal Stem Cells via Inducing Autophagy Through m6A/IGF2BPs/Beclin-1 Signal Axis	21
Current Perspectives of Limbal-Derived Stem Cells and its Application in Ocular Surface Regeneration and Limbal Stem Cell Transplantation	21
Drug screening platform using human induced pluripotent stem cell-derived atrial cardiomyocytes and optical mapping	21
Corneal stromal stem cells restore transparency after N2 injury in mice	20
A robust culture system to generate neural progenitors with gliogenic competence from clinically relevant induced pluripotent stem cells for treatment of spinal cord injury	20
Human Mesenchymal Stem/Stromal Cells in Immune Regulation and Therapy	20
Human cord blood-derived regulatory T-cell therapy modulates the central and peripheral immune response after traumatic brain injury	20
GDF11 enhances therapeutic efficacy of mesenchymal stem cells for myocardial infarction via YME1L-mediated OPA1 processing	20
A Pilot Study On Ex Vivo Expanded Autologous Adipose-Derived Stem Cells of Improving Fat Retention in Localized Scleroderma Patients	20
Protecting islet functional viability using mesenchymal stromal cells	20
Mesenchymal Stromal Cell-Secreted CCL2 Promotes Antibacterial Defense Mechanisms Through Increased Antimicrobial Peptide Expression in Keratinocytes	20
Potential of mesenchymal stem cells as topical immunomodulatory cell therapies for ocular surface inflammatory disorders	19
A Scalable System for Generation of Mesenchymal Stem Cells Derived from Induced Pluripotent Cells Employing Bioreactors and Degradable Microcarriers	19
Mesenchymal Stromal Cell Mitochondrial Transfer as a Cell Rescue Strategy in Regenerative Medicine: A Review of Evidence in Preclinical Models	19
Injectable BMP-2 gene-activated scaffold for the repair of cranial bone defect in mice	19

Safety and efficacy of intrarenal arterial autologous CD34+ cell transfusion in patients with chronic kidney disease: A randomized, open-label, controlled phase II clinical trial	19
Human perivascular stem cells prevent bone graft resorption in osteoporotic contexts by inhibiting osteoclast formation	19
CRISPRthripsis: The Risk of CRISPR/Cas9-induced Chromothripsis in Gene Therapy	19
Coronavirus disease 2019: A tissue engineering and regenerative medicine perspective	18
Human Retinal Organoids Provide a Suitable Tool for Toxicological Investigations: A Comprehensive Validation Using Drugs and Compounds Affecting the Retina	18
Elevated Glucosylsphingosine in Gaucher Disease induced Pluripotent Stem Cell Neurons Deregulates Lysosomal Compartment through Mammalian Target of Rapamycin Complex 1	18
Neural crest-like stem cells for tissue regeneration	17
Viral pandemic preparedness: A pluripotent stem cell-based machine-learning platform for simulating SARS-CoV-2 infection to enable drug discovery and repurposing	17
Enhanced structure and function of human pluripotent stem cell-derived beta-cells cultured on extracellular matrix	17
Human Dystrophin Expressing Chimeric (DEC) Cell Therapy Ameliorates Cardiac, Respiratory, and Skeletal Muscle's Function in Duchenne Muscular Dystrophy	17
Allogeneic Mesenchymal Stromal Cells for Cartilage Regeneration: A Review of in Vitro Evaluation, Clinical Experience, and Translational Opportunities	17
Tissue-specific mesenchymal stem cell-dependent osteogenesis in highly porous chitosan-based bone analogs	17
Differential Function and Maturation of Human Stem Cell-Derived Islets After Transplantation	17
Ex vivo conditioning of peripheral blood mononuclear cells of diabetic patients promotes vasculogenic wound healing	16
Production of Mesenchymal Progenitor Cell-Derived Extracellular Vesicles in Suspension Bioreactors for Use in Articular Cartilage Repair	16
Development and Investigational New Drug Application of Mesenchymal Stem/Stromal Cells Products in China	16
Current and Emerging Therapies for Limbal Stem Cell Deficiency	16
Perspective on human pluripotent stem cell-derived cardiomyocytes in heart disease modeling and repair	16
Establishment and neural differentiation of neural crest-derived stem cells from human dental pulp in serum-free conditions	16
Schwann Cells in the Aganglionic Colon of Hirschsprung Disease Can Generate Neurons for Regenerative Therapy	16
Site-Specific Integration of TRAIL in iPSC-Derived Mesenchymal Stem Cells for Targeted Cancer Therapy	16
SARS-CoV-2 Research Using Human Pluripotent Stem Cells and Organoids	16
Intraglandular Off-the-Shelf Allogeneic Mesenchymal Stem Cell Treatment in Patients with Radiation-Induced Xerostomia: A Safety Study (MESRIX-II)	16
Systemic DKK1 neutralization enhances human adipose-derived stem cell mediated bone repair	16
Definition and Characteristics of Mesenchymal Stromal Cells in Preclinical and Clinical Studies: A Scoping Review	16
pRB-Depleted Pluripotent Stem Cell Retinal Organoids Recapitulate Cell State Transitions of Retinoblastoma Development and Suggest an Important Role for pRB in Retinal Cell Differentiation	15
Three-Dimensional Spheroid Culture of Human Mesenchymal Stem Cells: Offering Therapeutic Advantages and In Vitro Glimpses of the In Vivo State	15
Controlled Aggregation Enhances Immunomodulatory Potential of Mesenchymal Stromal Cell Aggregates	15
Comparison of concentrated fresh mononuclear cells and cultured mesenchymal stem cells from bone marrow for bone regeneration	15
A Systematic Review and Meta-Analysis of Cell-Based Interventions in Experimental Diabetic Kidney Disease	15
CD34+ cell therapy significantly reduces adverse cardiac events, health care expenditures, and mortality in patients with refractory angina	15
The vascular nature of lung-resident mesenchymal stem cells	15
Transplantation of Human Autologous Synovial Mesenchymal Stem Cells with Trisomy 7 into the Knee Joint and 5 Years of Follow-up	15
Therapeutic Potential of Stem Cells from Human Exfoliated Deciduous Teeth Infusion into Patients with Type 2 Diabetes Depends on Basal Lipid Levels and Islet Function	15
A pre-investigational new drug study of lung spheroid cell therapy for treating pulmonary fibrosis	15
Umbilical Cord Blood and Cord Tissue-Derived Cell Therapies for Neonatal Morbidities: Current Status and Future Challenges	15
Culture substrate-associated YAP inactivation underlies chondrogenic differentiation of human induced pluripotent stem cells	15
Two phase I/II clinical trials for the treatment of urinary incontinence with autologous mesenchymal stem cells	15
Otic Organoids Containing Spiral Ganglion Neuron-like Cells Derived from Human-induced Pluripotent Stem Cells as a Model of Drug-induced Neuropathy	14
Extracellular Vesicles Derived From Neural Stem Cells, Astrocytes, and Microglia as Therapeutics for Easing TBI-Induced Brain Dysfunction	14
Decellularized skeletal muscles display neurotrophic effects in three-dimensional organotypic cultures	14
Mesenchymal Stem Cells and Three-Dimensional-Osteoconductive Scaffold Regenerate Calvarial Bone in Critical Size Defects in Swine	14
Ferulic Acid Promotes Bone Defect Repair After Radiation by Maintaining the Stemness of Skeletal Stem Cells	14
Coculture techniques for modeling retinal development and disease, and enabling regenerative medicine	14
Blood Vessel Resident Human Stem Cells in Health and Disease	14
Notch Signaling in the Dynamics of Perivascular Stem Cells and their Niches	14
The antifibrotic adipose-derived stromal cell: Grafted fat enriched with CD74+ adipose-derived stromal cells reduces chronic radiation-induced skin fibrosis	14
Transcriptional and functional characterization of neonatal circulating Innate Lymphoid Cells	14
Retinal Cell Transplantation, Biomaterials, and In Vitro Models for Developing Next-generation Therapies of Age-related Macular Degeneration	13
Retrieval of germinal zone neural stem cells from the cerebrospinal fluid of premature infants with intraventricular hemorrhage	13
Mesenchymal stromal cells for sepsis and septic shock: Lessons for treatment of COVID-19	13
Stem Cell Therapies for Chronic Liver Diseases: Progress and Challenges	13
Mesenchymal Stem Cell-derived Extracellular Vesicles Prevent Experimental Bronchopulmonary Dysplasia Complicated By Pulmonary Hypertension	13
Coadministration of endothelial and smooth muscle cells derived from human induced pluripotent stem cells as a therapy for critical limb ischemia	13
Safety and efficacy of Wharton's jelly-derived mesenchymal stem cells with teriparatide for osteoporotic vertebral fractures: A phase I/IIa study	13
Donor-Defined Mesenchymal Stem Cell Antimicrobial Potency Against Nontuberculous Mycobacterium	13
Efficacy and Safety of MSC Cell Therapies for Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis	13
Adipose Micro-Grafts Enhance Tendinopathy Healing in Ovine Model: An in Vivo Experimental Perspective Study	12
High-throughput screening in postimplantation haploid epiblast stem cells reveals Hs3st3b1 as a modulator for reprogramming	12
CD34+CD146+ adipose-derived stromal cells enhance engraftment of transplanted fat	12
Neuronal Cell-based Medicines from Pluripotent Stem Cells: Development, Production, and Preclinical Assessment	12
Killers at the crossroads: The use of innate immune cells in adoptive cellular therapy of cancer	12
CAR-NK Cells from Engineered Pluripotent Stem Cells: Off-the-shelf Therapeutics for all Patients	12
Overexpression of alpha-1 antitrypsin in mesenchymal stromal cells improves their intrinsic biological properties and therapeutic effects in nonobese diabetic mice	12
Modulation of the Activity of Stem and Progenitor Cells by Immune Cells	12
Phase I clinical trial of intra-bone marrow cotransplantation of mesenchymal stem cells in cord blood transplantation	12
Stem cell mobilization with plerixafor and healing of diabetic ischemic wounds: A phase IIa, randomized, double-blind, placebo-controlled trial	12
Safety of Human Embryonic Stem Cell-derived Mesenchymal Stem Cells for Treating Interstitial Cystitis: A Phase I Study	12
Phase IV Postmarketing Surveillance Study Shows Continued Efficacy and Safety of Stempeucel in Patients with Critical Limb Ischemia Due to Buerger's Disease	12
Human endothelial colony-forming cells in regenerative therapy: A systematic review of controlled preclinical animal studies	12
Mitomycin-C treatment during differentiation of induced pluripotent stem cell-derived dopamine neurons reduces proliferation without compromising survival or function in vivo	12
Preclinical safety studies of human embryonic stem cell-derived retinal pigment epithelial cells for the treatment of age-related macular degeneration	12
Neural Stem Cell Treatment for Perinatal Brain Injury: A Systematic Review and Meta-Analysis of Preclinical Studies	12
Cell-based and antibody-mediated immunotherapies directed against leukemic stem cells in acute myeloid leukemia: Perspectives and open issues	11
Facile Bead-to-Bead Cell-Transfer Method for Serial Subculture and Large-Scale Expansion of Human Mesenchymal Stem Cells in Bioreactors	11
Metabolic Maturation Increases Susceptibility to Hypoxia-induced Damage in Human iPSC-derived Cardiomyocytes	11
Rejuvenation of Tissue Stem Cells by Intrinsic and Extrinsic Factors	11
Premigratory neural crest stem cells generate enteric neurons populating the mouse colon and regulating peristalsis in tissue-engineered intestine	11
The Heterogeneity of Megakaryocytes and Platelets and Implications for Ex Vivo Platelet Generation	11
Chemokine Assay Matrix Defines the Potency of Human Bone Marrow Mesenchymal Stromal Cells	11

Magnetic targeting increases mesenchymal stromal cell retention in lungs and enhances beneficial effects on pulmonary damage in experimental silicosis	11
Effects of Mesenchymal Stem Cell Transplantation on Cerebrospinal Fluid Biomarkers in Progressive Multiple Sclerosis	11
Suppression of inflammation and fibrosis using soluble epoxide hydrolase inhibitors enhances cardiac stem cell-based therapy	11
Recapturing embryonic potential in the adult epicardium: Prospects for cardiac repair	11
Window of opportunity for human amnion epithelial stem cells to attenuate astrogliosis after umbilical cord occlusion in preterm fetal sheep	11
Sensory nerves in the spotlight of the stem cell niche	11
Sibling Umbilical Cord Blood Infusion is Safe in Young Children with Cerebral Palsy	10
Efficacy of MSC in Patients with Severe COVID-19: Analysis of the Literature and a Case Study	10
Adipose-Derived Stromal Cells for Chronic Wounds: Scientific Evidence and Roadmap Toward Clinical Practice	10
Stem Cell Therapies for Central Nervous System Trauma: The 4 Ws—What, When, Where, and Why	10
Carm1 and the Epigenetic Control of Stem Cell Function	10
Erythropoietin in bone homeostasis—Implications for efficacious anemia therapy	10
Treatment with Amniotic Fluid Stem Cell Extracellular Vesicles Promotes Fetal Lung Branching and Cell Differentiation at Canalicular and Saccular Stages in Experimental Pulmonary Hypoplasia Secondary	10
Novel Mesenchymal Stem Cell Spheroids with Enhanced Stem Cell Characteristics and Bone Regeneration Ability	10
Rehabilitative Training Enhances Therapeutic Effect of Human iPSC-Derived Neural Stem/Progenitor Cells Transplantation in Chronic Spinal Cord Injury	10
The Influence of Cancer Stem Cells on the Risk of Relapse in Adenocarcinoma and Squamous Cell Carcinoma of the Lung: A Prospective Cohort Study	10
Mesenchymal Stromal Cells for Treating Steroid-Resistant Acute and Chronic Graft Versus Host Disease: A Multicenter Compassionate Use Experience	10
The Crosstalk Between Adipose-Derived Stem or Stromal Cells (ASC) and Cancer Cells and ASC-Mediated Effects on Cancer Formation and Progression—ASCs: Safety Hazard or Harmless Source of Tropism?	10