OOIR: Observatory of International Research

Papers

(The TQCC of Cold Spring Harbor Perspectives in Medicine is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Knowledge-Based Therapeutics for Tricarboxylic Acid (TCA) Cycle-Deficient Cancers	464
Oncogenic Control of Metabolism	291
Adoptive Cell Therapy for Pediatric Solid Tumors	148
Type 1 Diabetes: Advances in Understanding and Treatment 100 Years after the Discovery of Insulin	35
The Teplizumab Saga: The Challenge of Not Getting Lost in Clinical Translation	34
Gene-Expression Profiling to Decipher Breast Cancer Inter- and Intratumor Heterogeneity	31
The Human Pancreas in Type 1 Diabetes: Lessons Learned from the Network of Pancreatic Organ Donors with Diabetes	30
Photoreceptor Cell Replacement Using Pluripotent Stem Cells: Current Knowledge and Remaining Questions	29
Addressing Biological Questions with Preclinical Cancer Imaging	20
Corrigendum: Preclinical Modeling of Pathway-Targeted Therapy of Human Lung Cancer in the Mouse	20
Toward a Unified Theory of Why Young People Develop Cancer	19
Epidemiology and Risk Factors for Breast Cancer: 21st Century Advances, Gaps to Address through Interdisciplinary Science	19
Advances in Making Cancer Mouse Models More Accessible and Informative through Non-Germline Genetic Engineering	18
Lymphatic Tissue and Organ Engineering for In Vitro Modeling and In Vivo Regeneration	15
iPSC-RPE in Retinal Degeneration: Recent Advancements and Future Perspectives	14
Geroscience and Its Promise	13
Endothelial Cell–Pericyte Interactions in the Pathogenesis of Cerebral Cavernous Malformations (CCMs)	13
Germline Genetic Testing for Hereditary Breast and Ovarian Cancer: Current Concepts in Risk Evaluation	12
The Breast Cancer Proteome and Precision Oncology	12
Organoid Cultures for the Study of Mammary Biology and Breast Cancer: The Promise and Challenges	11
International Gains to Achieving Healthy Longevity	11
Mobility Testing and Other Performance-Based Assessments of Functional Vision in Patients with Inherited Retinal Disease	10
Immunometabolic Maladaptations to the Tumor Microenvironment	10
Choroideremia: Toward Regulatory Approval of Retinal Gene Therapy	10
Mechanisms Regulating T Cell–Endothelial Cell Interactions	9

Developmental Oncology: Principles and Therapy of Cancers of Children and Young Adults	9
Beyond Static Pipes: Mechanisms and In Vitro Models of Vascular Aging	9
Advances in Islet Transplantation and the Future of Stem Cell–Derived Islets to Treat Diabetes	9
Developmental Heterogeneity of Rhabdomyosarcoma	9
Checkpoint Inhibitor-Induced Autoimmune Diabetes: An Autoinflammatory Disease	9
Prostanoids Regulate Angiogenesis and Lymphangiogenesis in Pathological Conditions	8
Modeling Brain Vasculature Immune Interactions In Vitro	8
Environmental Factors in Type 1 Diabetes	8
The Emerging Role of the Single-Cell and Spatial Tumor Microenvironment in High-Grade Serous Ovarian Cancer	8
Developmental Modeling of Childhood Cancers	8
Developing New Vectors for Retinal Gene Therapy	7
Cell-Based Therapies: Strategies for Regeneration	7
Advances in Studying Cancer Immunology in Mice	7
Monitoring the Cell Cycle of Tumor Cells in Mouse Models of Human Cancer	7
MicroRNAs in Mechanical Homeostasis	7
Wnt/frizzled Signaling in Endothelium: A Major Player in Blood-Retinal- and Blood-Brain-Barrier Integrity	7
Imaging of Disease-Related Networks in Parkinson's Disease	6
Targeting Hyperactive Ras Signaling in Pediatric Cancer	6
Lymphatic Clearance and Pump Function	6
Lung Cancer Computational Biology and Resources	6
X-Linked Retinoschisis	6
Spatial Biology of Breast Cancer	6
Imaging Approaches in Cancer Biology	5
Ovarian Clear Cell Carcinoma: An Endometriosis-Associated Cancer with Therapeutic Challenges	5
Molecular Mechanisms Driving Lymphedema and Other Lymphatic Anomalies	5
Overview of Retinal Gene Therapy: Current Status and Future Challenges	5
Metabolic Signaling in Cancer	5
Signal Transduction and Gene Regulation in the Endothelium	5
Corrigendum: Toward Retinal Organoids in High-Throughput	5
Personalized Financial Planning Using Applied Genetics	5
Role of Tumor Cell Intrinsic and Host Autophagy in Cancer	5
Understanding the Warburg Effect in Cancer	5