OOIR: Observatory of International Research

Papers

(The median citation count of Cold Spring Harbor Perspectives in Medicine is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Developmental Oncology: Principles and Therapy of Cancers of Children and Young Adults	152
Tuberculosis Drug Discovery in the Age of Artificial Intelligence	50
iPSC-RPE in Retinal Degeneration: Recent Advancements and Future Perspectives	49
Dermatophytes: Global Pandemic, Multidrug Resistance, Human-to-Human, and Sexual Transmission	45
Monitoring the Cell Cycle of Tumor Cells in Mouse Models of Human Cancer	41
Metabolic Signaling in Cancer	40
Pediatric Tuberculosis: Epidemiology, Disease Spectrum, Diagnosis, and Management	39
Developing New Vectors for Retinal Gene Therapy	38
Toward Retinal Organoids in High-Throughput	32
Pathomechanisms of Inherited Retinal Degeneration and Perspectives for Neuroprotection	29
Personalized Financial Planning Using Applied Genetics	27
Ovarian Clear Cell Carcinoma: An Endometriosis-Associated Cancer with Therapeutic Challenges	26
Embryological Insights into the Origin of Epithelial Cancers of the Female Reproductive Tract	24
How CRISPR Is Revolutionizing the Generation of New Models for Cancer Research	23
Genetics and Epigenetics of Type 1 Diabetes Self-Reactive T Cells	22
Clinical Immunologic Interventions for the Treatment of Type 1 Diabetes: Challenges, Choice, and Timing of Immunomodulators	20
Inflammatory β-Cell Stress and Immune Surveillance in Type 1 Diabetes	20
α-Synuclein in Parkinson's Disease: 12 Years Later	19
Host Biomarkers in Tuberculosis	19
From the Inside Out: Exposing the Roles of Urea Cycle Enzymes in Tumors and Their Micro and Macro Environments	19
Retinal Disorders	18
Mechanisms of Organ-Specific Metastasis of Breast Cancer	18
Optogenetic Vision Restoration	16
Functional Neuroanatomy of the Normal and Pathological Basal Ganglia	16
Therapeutic Gene Editing in Inherited Retinal Disorders	16

Imaging Modalities in Tuberculosis	15
From Parasite to Pill: Harnessing Biology for Breakthroughs in Antimalarial Drug Discovery	15
Aging and Inflammation	14
Who Are the Space Invaders? Planetary Protection and the Role of Biological Interactions between Extraterrestrial and Terrestrial Biospheres	14
Lessons Learned from the Development of the First FDA-Approved Gene Therapy Drug, Voretigene Neparvovec-rzyl	13
Innate Immunity in Type 1 Diabetes	13
Lipid Alterations and Pathogenic Roles in Synucleinopathies	13
Breast Cancer Immunity: It is TIME for the Next Chapter	13
Autophagy and Protein Quality Control in Parkinson's Disease	13
The Funding Channels of Geroscience	13
Immunology of Retinitis Pigmentosa and Gene Therapy–Associated Uveitis	13
Epitope Hierarchy in Type 1 Diabetes Pathogenesis	12
Early Detection of Ovarian Cancer	12
Models of High-Grade Serous Ovarian Carcinoma	12
Acute Promyelocytic Leukemia, Retinoic Acid, and Arsenic: A Tale of Dualities	12
From Life Span to Health Span: Declaring “Victory” in the Pursuit of Human Longevity	12
A History of Biosafety: U.S. Perspective	11
The Pathogenesis of Type 1 Diabetes	11
Toward a Unified Theory of Why Young People Develop Cancer	11
Modeling Brain Vasculature Immune Interactions In Vitro	11
Evolutionary Approaches in Aging Research	11
T Cell Differentiation in Autoimmune Type 1 Diabetes	10
Leucine-Rich Repeat Kinase 2: Pathways to Parkinson's Disease	10
The Human Pancreas in Type 1 Diabetes: Lessons Learned from the Network of Pancreatic Organ Donors with Diabetes	10
The Power and Promise of Patient-Derived Xenografts of Human Breast Cancer	10
Next-Generation Modeling of Cancer Using Organoids	10
Understanding the Warburg Effect in Cancer	10
Germline Genetic Testing for Hereditary Breast and Ovarian Cancer: Current Concepts in Risk Evaluation	10
Retinal Degeneration Animal Models in Bardet–Biedl Syndrome and Related Ciliopathies	10
The Mouse Model of Tuberculosis: Uses and Abuses	10
Technologies for Decoding Cancer Metabolism with Spatial Resolution	10
Comparison of Worldwide Disease Prevalence and Genetic Prevalence of Inherited Retinal Diseases and Variant Interpretation Considerations	10
Dormancy in Breast Cancer	10
Emerging Therapies for Breast Cancer	10
New Paradigms in the Clinical Management of Li–Fraumeni Syndrome	10
Angiogenesis and Microvascular Permeability	9
The Extraordinary Phenotypic and Genetic Variability of Retinal and Macular Degenerations: The Relevance to Therapeutic Developments	9
History of Finding Genes and Mutations Causing Inherited Retinal Diseases	9
Safety and Security in the Lithotroph of Microbiology—A Commentary	9
Cellular Origins and Lineage Plasticity in Cancer	9
Update on Tuberculosis Treatment and Drug Regimens	9
Tuberculosis Infection: Diagnosis and Management	9
The Global Epidemiology of Tuberculosis: Burden, Trends, and Determinants	9
Diagnostic Assays for TB Disease and Drug Resistance Detection—Advances and Latest WHO Recommendations	9
Rare Epithelial Ovarian Cancers: Low Grade Serous and Mucinous Carcinomas	9
Parallels in Canonical Developmental Signaling Pathways between Normal Development and the Tumor Microenvironment	9
The Chicken or the Egg Dilemma: Understanding the Interplay between the Immune System and the β Cell in Type 1 Diabetes	8
Immunodominant Tuberculosis Antigens Recognized by Human CD4 ⁺ and CD8 ⁺ T Cells	8
Osteosarcoma through the Lens of Bone Development, Signaling, and Microenvironment	8
Beyond the NEI-VFQ: Recent Experience in the Development and Utilization of Patient-Reported Outcomes for Inherited Retinal Diseases	8

Mechanics of Lymphatic Pumping and Lymphatic Function	8
Canine and Feline Models of Inherited Retinal Diseases	8
Regulation of the Blood–Brain Barrier in Health and Disease	8
Historical Perspectives of Parkinson's Disease: Early Clinical Descriptions and Neurological Therapies	8
Corrigendum: Preclinical Modeling of Pathway-Targeted Therapy of Human Lung Cancer in the Mouse	7
International Gains to Achieving Healthy Longevity	7
Cell-Based Therapies: Strategies for Regeneration	7
Parkinson's Disease, Second Edition	7
Host Cell Death Signaling Pathways Manipulated by Mycobacterium tuberculosis	7
Developmental Heterogeneity of Rhabdomyosarcoma	7
Organoid Cultures for the Study of Mammary Biology and Breast Cancer: The Promise and Challenges	7
The Breast Cancer Proteome and Precision Oncology	7
Advances in Making Cancer Mouse Models More Accessible and Informative through Non-Germline Genetic Engineering	7
Imaging of Disease-Related Networks in Parkinson's Disease	6
Spatial Biology of Breast Cancer	6
Tracing the Diverse Paths of One-Carbon Metabolism in Cancer and Beyond	6
Mobility Testing and Other Performance-Based Assessments of Functional Vision in Patients with Inherited Retinal Disease	6
RPGR-Related Retinopathy: Clinical Features, Molecular Genetics, and Gene Replacement Therapy	6
From Empirical Discovery to Targeted Therapy: The Evolution of Tuberculosis Treatment	6
Metabolic Reprogramming in Human Cancer Patients and Patient-Derived Models	6
Lymphatic Clearance and Pump Function	6
Checkpoint Inhibitor-Induced Autoimmune Diabetes: An Autoinflammatory Disease	6
Effector Functions of Conventional and Unconventional Mycobacterium tuberculosis ( Mtb )-Specific T Cells	5
Breakdown and Repair of Peripheral Immune Tolerance in Type 1 Diabetes	5
Restoration of Rod-Derived Metabolic and Redox Signaling to Prevent Blindness	5
Mouse Models to Evaluate the Functional Role of the Tumor Microenvironment in Cancer Progression and Therapy Responses	5
The Role of Stroma in Cancer Metabolism	5
Threats from the Fungal Kingdom	5
Chromatin Variants Reveal the Genetic Determinants of Oncogenesis in Breast Cancer	5
From Phagosomes to Niches: Macrophage Biology in Tuberculosis Revisited	5
Cancer Therapies Targeting Cellular Metabolism	5
From Bench to Bedside—Delivering Gene Therapy for Leber Hereditary Optic Neuropathy	5
Extracellular Matrix Regulation of Vascular Morphogenesis, Maturation, and Stabilization	5
Crowdfunding and Crowdsourcing of Aging Science	5
Mutations, Bottlenecks, and Clonal Sweeps: How Environmental Carcinogens and Genomic Changes Shape Clonal Evolution during Tumor Progression	5
Biological Restraints on Indefinite Survival	5
Integrating Omics into Functional Biomarkers of Type 1 Diabetes	4
Trial by “Firsts”: Clinical Trial Design and Regulatory Considerations in the Development and Approval of the First AAV Gene Therapy Product in the United States	4
Imaging Tumor Metabolism	4
Host-Directed Therapies for Tuberculosis	4
Diagnosing Tuberculosis Infection: From the Host to the Pathogen	4
Cancer Metabolism Historical Perspectives: A Chronicle of Controversies and Consensus	4
The Role of the National Institute on Aging in the Development of the Field of Geroscience	4
Cancer Metabolism under Limiting Oxygen Conditions	4
Gene Therapies for Retinitis Pigmentosa that Target Glucose Metabolism	4
The Mitochondrial Connection in Parkinson's Disease	4
Addendum to Dopamine Cell-Based Replacement Therapies	4
Mitochondrial Targeted Interventions for Aging	4