OOIR: Observatory of International Research

Papers

(The median citation count of Cold Spring Harbor Perspectives in Medicine is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
Multivariable Mendelian Randomization and Mediation	216
Mendelian Randomization: Concepts and Scope	203
The Evolution and Biology of SARS-CoV-2 Variants	104
Mendelian Randomization	82
Using Mendelian Randomization to Improve the Design of Randomized Trials	64
Mechanisms of Nicotine Addiction	59
H7N9 Influenza Virus in China	53
Structure and Function of Influenza Polymerase	43
Application of Radiomics and Artificial Intelligence for Lung Cancer Precision Medicine	43
Influenza Polymerase Inhibitors: Mechanisms of Action and Resistance	37
Polygenic Mendelian Randomization	32
Advances in Small-Cell Lung Cancer (SCLC) Translational Research	32
Twins and Causal Inference: Leveraging Nature's Experiment	28
Chronic Lymphocytic Leukemia	28
Triangulating Evidence through the Inclusion of Genetically Informed Designs	28
Neural Substrates and Circuits of Drug Addiction	27
Emerging HxNy Influenza A Viruses	27
The Evolution and Ecology of Resistance in Cancer Therapy	27
Equine Influenza	25
Antivirals Targeting the Neuraminidase	25
Hemagglutinin Structure and Activities	21
Next-Generation Influenza Vaccines	20
Tumor Immunology and Immunotherapy of Non-Small-Cell Lung Cancer	20
Epigenetics of Drug Addiction	20
Integrating Family-Based and Mendelian Randomization Designs	19

Glutamatergic Systems and Memory Mechanisms Underlying Opioid Addiction	17
Targeting Epigenetics in Lung Cancer	17
Family-Based Designs that Disentangle Inherited Factors from Pre- and Postnatal Environmental Exposures: In Vitro Fertilization, Discordant Sibling Pairs, Maternal versus Paternal Comparisons, and Ado	17
Human Genomics and Drug Development	16
Buttons and Zippers: Endothelial Junctions in Lymphatic Vessels	15
MAP-Kinase-Driven Hematopoietic Neoplasms: A Decade of Progress in the Molecular Age	15
Neonatal Opioid Withdrawal Syndrome (NOWS): A Transgenerational Echo of the Opioid Crisis	15
Human Influenza Epidemiology	15
H5 Influenza Viruses in Egypt	15
Host Cell Factors That Interact with Influenza Virus Ribonucleoproteins	14
The Meaning of “Cause” in Genetics	14
Innate Immunity in Hepatitis C Virus Infection	13
Influenza Immunization in the Context of Preexisting Immunity	13
Animal Models of the Behavioral Symptoms of Substance Use Disorders	13
Drug-Evoked Synaptic Plasticity of Excitatory Transmission in the Ventral Tegmental Area	13
Notch Signaling in the Vasculature: Angiogenesis and Angiocrine Functions	13
Induction and Evasion of Type-I Interferon Responses during Influenza A Virus Infection	12
Systems Biological Analysis of Immune Response to Influenza Vaccination	11
Accessory Gene Products of Influenza A Virus	11
HCV Assembly and Egress via Modifications in Host Lipid Metabolic Systems	11
Selective Genome Packaging Mechanisms of Influenza A Viruses	11
Biology and Molecular Pathogenesis of Mature T-Cell Lymphomas	10
Early Diagnosis and Screening for Lung Cancer	10
Lymphedema and Obesity	9
Causal Inference Methods to Integrate Omics and Complex Traits	9
Immunotherapy Approaches for Breast Cancer Patients in 2023	9
Impairment of Synaptic Plasticity by Cannabis, Δ⁹-THC, and Synthetic Cannabinoids	9
Preclinical Models for the Study of Lung Cancer Pathogenesis and Therapy Development	8
Molecular Pathology of Lung Cancer	8
Consequences of Parental Opioid Exposure on Neurophysiology, Behavior, and Health in the Next Generations	8
Live Attenuated Cold-Adapted Influenza Vaccines	8
Platelets and (Lymph)angiogenesis	7
The Role of Somatic Mutations in Acute Myeloid Leukemia Pathogenesis	7
Causal Inference with Genetic Data: Past, Present, and Future	7
Antibody Responses in Hepatitis C Infection	7
Endothelial Cell Differentiation and Hemogenic Specification	7
Developments from Bulk Optogenetics to Single-Cell Strategies to Dissect the Neural Circuits that Underlie Aberrant Motivational States	6
Radiation Therapy in Non-Small-Cell Lung Cancer	6
Endothelialitis, Microischemia, and Intussusceptive Angiogenesis in COVID-19	6
Genetic Vulnerability to Opioid Addiction	6
Dormancy in Breast Cancer	6
Endothelial Cell Fate Determination: A Top Notch Job in Vascular Decision-Making	5
MicroRNAs in Mechanical Homeostasis	5
Lessons Learned from the Development of the First FDA-Approved Gene Therapy Drug, Voretigene Neparvovec-rzyl	5
Targeting Angiogenesis via Resolution of Inflammation	5
Lung Cancer Stem Cells and Their Clinical Implications	5
Developing New Vectors for Retinal Gene Therapy	5
T-Cell Immunity against the Hepatitis C Virus: A Persistent Research Priority in an Era of Highly Effective Therapy	4
Human Endothelial Colony-Forming Cells	4
Mechanisms of Organ-Specific Metastasis of Breast Cancer	4

RPGR-Related Retinopathy: Clinical Features, Molecular Genetics, and Gene Replacement Therapy	4
Evolutionary Approaches in Aging Research	4
Notch Signaling in Vascular Endothelial and Mural Cell Communications	4
Wnt/frizzled Signaling in Endothelium: A Major Player in Blood-Retinal- and Blood-Brain-Barrier Integrity	4
Corrigendum: Mechanism of Bone Mineralization	4
Retraction: The Evolution and Ecology of Resistance in Cancer Therapy	4
The Persistent Challenge of Developing Addiction Pharmacotherapies	3
Alternative RNA Splicing in the Retina: Insights and Perspectives	3
Retinal Degeneration Animal Models in Bardet–Biedl Syndrome and Related Ciliopathies	3
Pathomechanisms of Inherited Retinal Degeneration and Perspectives for Neuroprotection	3
From Life Span to Health Span: Declaring “Victory” in the Pursuit of Human Longevity	3
Lymphatics in Cardiovascular Physiology	3
Extracellular Matrix Regulation of Vascular Morphogenesis, Maturation, and Stabilization	3
Non-Hodgkin Lymphomas: Malignancies Arising from Mature B Cells	3
Computational Tools for Causal Inference in Genetics	3
Electronic Retinal Prostheses	3
Leukocyte Trafficking in Lymphatic Vessels	3
Lymphatic Vascular Permeability	3
Overview of Retinal Gene Therapy: Current Status and Future Challenges	3
Endothelial Cell–Pericyte Interactions in the Pathogenesis of Cerebral Cavernous Malformations (CCMs)	3
High-Throughput Identification, Modeling, and Analysis of Cancer Driver Genes In Vivo	2
The Role of the National Institute on Aging in the Development of the Field of Geroscience	2
Oncogenic Mechanisms and Therapeutic Targeting of Metabolism in Leukemia and Lymphoma	2
The Beauty and Complexity of Blood Vessel Patterning	2
A History of Cancer Research: Carcinogens and Mutagens	2
Emerging Therapies for Breast Cancer	2
Choroideremia: Toward Regulatory Approval of Retinal Gene Therapy	2
Lymphatic Tissue and Organ Engineering for In Vitro Modeling and In Vivo Regeneration	2
Gene Therapies for Retinitis Pigmentosa that Target Glucose Metabolism	2
Adaptive Optics Imaging of Inherited Retinal Disease	2
Trial by “Firsts”: Clinical Trial Design and Regulatory Considerations in the Development and Approval of the First AAV Gene Therapy Product in the United States	2
Advances in Immunocompetent Mouse and Rat Models	2
A Systematic Review of Optogenetic Vision Restoration: History, Challenges, and New Inventions from Bench to Bedside	2
Endothelial Lipid Metabolism	2
Cell-Based Therapies: Strategies for Regeneration	2
International Gains to Achieving Healthy Longevity	2
Gene Therapy for Rhodopsin Mutations	2
Beyond the NEI-VFQ: Recent Experience in the Development and Utilization of Patient-Reported Outcomes for Inherited Retinal Diseases	2
Endothelial Connexins in Developmental and Pathological Angiogenesis	2
Therapeutic Gene Editing in Inherited Retinal Disorders	2
From Bench to Bedside—Delivering Gene Therapy for Leber Hereditary Optic Neuropathy	2
Discovering Biological Mechanisms of Exceptional Human Health Span and Life Span	2
Modeling Brain Vasculature Immune Interactions In Vitro	2
Mouse Models in the Study of Mature B-Cell Malignancies	2