OOIR: Observatory of International Research

Papers

(The median citation count of Cold Spring Harbor Perspectives in Medicine is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
iPSC-RPE in Retinal Degeneration: Recent Advancements and Future Perspectives	484
Developmental Oncology: Principles and Therapy of Cancers of Children and Young Adults	310
Monitoring the Cell Cycle of Tumor Cells in Mouse Models of Human Cancer	149
Metabolic Signaling in Cancer	42
Pathomechanisms of Inherited Retinal Degeneration and Perspectives for Neuroprotection	38
Ovarian Clear Cell Carcinoma: An Endometriosis-Associated Cancer with Therapeutic Challenges	33
Personalized Financial Planning Using Applied Genetics	31
Developing New Vectors for Retinal Gene Therapy	31
Toward Retinal Organoids in High-Throughput	30
How CRISPR Is Revolutionizing the Generation of New Models for Cancer Research	22
Inflammatory β-Cell Stress and Immune Surveillance in Type 1 Diabetes	21
Embryological Insights into the Origin of Epithelial Cancers of the Female Reproductive Tract	20
From the Inside Out: Exposing the Roles of Urea Cycle Enzymes in Tumors and Their Micro and Macro Environments	19
Clinical Immunologic Interventions for the Treatment of Type 1 Diabetes: Challenges, Choice, and Timing of Immunomodulators	16
Genetics and Epigenetics of Type 1 Diabetes Self-Reactive T Cells	16
Mechanisms of Organ-Specific Metastasis of Breast Cancer	16
Retinal Disorders	15
α-Synuclein in Parkinson's Disease: 12 Years Later	15
Functional Neuroanatomy of the Normal and Pathological Basal Ganglia	14
Therapeutic Gene Editing in Inherited Retinal Disorders	14
Preclinical Models for the Study of Lung Cancer Pathogenesis and Therapy Development	13
Optogenetic Vision Restoration	13
Endothelial Cell Differentiation and Hemogenic Specification	12
Innate Immunity in Type 1 Diabetes	12
Aging and Inflammation	12

Autophagy and Protein Quality Control in Parkinson's Disease	11
Immunology of Retinitis Pigmentosa and Gene Therapy–Associated Uveitis	10
From Life Span to Health Span: Declaring “Victory” in the Pursuit of Human Longevity	10
Evolutionary Approaches in Aging Research	10
Breast Cancer Immunity: It is TIME for the Next Chapter	10
The Pathogenesis of Type 1 Diabetes	10
Lessons Learned from the Development of the First FDA-Approved Gene Therapy Drug, Voretigene Neparvovec-rzyl	9
Epitope Hierarchy in Type 1 Diabetes Pathogenesis	9
Acute Promyelocytic Leukemia, Retinoic Acid, and Arsenic: A Tale of Dualities	9
Early Detection of Ovarian Cancer	9
The Human Pancreas in Type 1 Diabetes: Lessons Learned from the Network of Pancreatic Organ Donors with Diabetes	9
The Funding Channels of Geroscience	9
Toward a Unified Theory of Why Young People Develop Cancer	8
Beyond Static Pipes: Mechanisms and In Vitro Models of Vascular Aging	8
Lymphatic Tissue and Organ Engineering for In Vitro Modeling and In Vivo Regeneration	8
A History of Biosafety: U.S. Perspective	8
Modeling Brain Vasculature Immune Interactions In Vitro	8
Germline Genetic Testing for Hereditary Breast and Ovarian Cancer: Current Concepts in Risk Evaluation	8
Wnt/frizzled Signaling in Endothelium: A Major Player in Blood-Retinal- and Blood-Brain-Barrier Integrity	8
Comparison of Worldwide Disease Prevalence and Genetic Prevalence of Inherited Retinal Diseases and Variant Interpretation Considerations	7
T Cell Differentiation in Autoimmune Type 1 Diabetes	7
Endothelial Lipid Metabolism	7
Understanding the Warburg Effect in Cancer	7
Dormancy in Breast Cancer	6
Notch Signaling in Vascular Endothelial and Mural Cell Communications	6
Rare Epithelial Ovarian Cancers: Low Grade Serous and Mucinous Carcinomas	6
New Paradigms in the Clinical Management of Li–Fraumeni Syndrome	6
Retinal Degeneration Animal Models in Bardet–Biedl Syndrome and Related Ciliopathies	6
Cellular Origins and Lineage Plasticity in Cancer	6
The Extraordinary Phenotypic and Genetic Variability of Retinal and Macular Degenerations: The Relevance to Therapeutic Developments	6
Parallels in Canonical Developmental Signaling Pathways between Normal Development and the Tumor Microenvironment	6
Next-Generation Modeling of Cancer Using Organoids	6
The Power and Promise of Patient-Derived Xenografts of Human Breast Cancer	6
Emerging Therapies for Breast Cancer	6
Technologies for Decoding Cancer Metabolism with Spatial Resolution	6
Angiogenesis and Microvascular Permeability	5
History of Finding Genes and Mutations Causing Inherited Retinal Diseases	5
Osteosarcoma through the Lens of Bone Development, Signaling, and Microenvironment	5
Mechanics of Lymphatic Pumping and Lymphatic Function	5
Regulation of the Blood–Brain Barrier in Health and Disease	5
Lung Cancer Stem Cells and Their Clinical Implications	5
Historical Perspectives of Parkinson's Disease: Early Clinical Descriptions and Neurological Therapies	5
Metabolic Phenotypes, Dependencies, and Adaptation in Lung Cancer	4
Human Endothelial Colony-Forming Cells	4
Checkpoint Inhibitor-Induced Autoimmune Diabetes: An Autoinflammatory Disease	4
Advances in Making Cancer Mouse Models More Accessible and Informative through Non-Germline Genetic Engineering	4
Spatial Biology of Breast Cancer	4
International Gains to Achieving Healthy Longevity	4
Beyond the NEI-VFQ: Recent Experience in the Development and Utilization of Patient-Reported Outcomes for Inherited Retinal Diseases	4
Lymphedema and Obesity	4

Corrigendum: Preclinical Modeling of Pathway-Targeted Therapy of Human Lung Cancer in the Mouse	4
Tracing the Diverse Paths of One-Carbon Metabolism in Cancer and Beyond	4
Cell-Based Therapies: Strategies for Regeneration	4
Canine and Feline Models of Inherited Retinal Diseases	4
The Chicken or the Egg Dilemma: Understanding the Interplay between the Immune System and the β Cell in Type 1 Diabetes	4
Mobility Testing and Other Performance-Based Assessments of Functional Vision in Patients with Inherited Retinal Disease	4
The Breast Cancer Proteome and Precision Oncology	4
Organoid Cultures for the Study of Mammary Biology and Breast Cancer: The Promise and Challenges	4
Developmental Heterogeneity of Rhabdomyosarcoma	4
Lymphatic Clearance and Pump Function	3
Chromatin Variants Reveal the Genetic Determinants of Oncogenesis in Breast Cancer	3
Mutations, Bottlenecks, and Clonal Sweeps: How Environmental Carcinogens and Genomic Changes Shape Clonal Evolution during Tumor Progression	3
Threats from the Fungal Kingdom	3
Metabolic Reprogramming in Human Cancer Patients and Patient-Derived Models	3
Mendelian Randomization	3
Restoration of Rod-Derived Metabolic and Redox Signaling to Prevent Blindness	3
Cancer Therapies Targeting Cellular Metabolism	3
RPGR-Related Retinopathy: Clinical Features, Molecular Genetics, and Gene Replacement Therapy	3
Crowdfunding and Crowdsourcing of Aging Science	3
Extracellular Matrix Regulation of Vascular Morphogenesis, Maturation, and Stabilization	3
Molecular Pathology of Lung Cancer	3
Tumor Immunology and Immunotherapy of Non-Small-Cell Lung Cancer	3
From Bench to Bedside—Delivering Gene Therapy for Leber Hereditary Optic Neuropathy	3
Biological Restraints on Indefinite Survival	3
Breakdown and Repair of Peripheral Immune Tolerance in Type 1 Diabetes	3
The Role of Stroma in Cancer Metabolism	3
Imaging of Disease-Related Networks in Parkinson's Disease	3
The Role of the National Institute on Aging in the Development of the Field of Geroscience	2
Gene Therapies for Retinitis Pigmentosa that Target Glucose Metabolism	2
Trial by “Firsts”: Clinical Trial Design and Regulatory Considerations in the Development and Approval of the First AAV Gene Therapy Product in the United States	2
Cancer Metabolism Historical Perspectives: A Chronicle of Controversies and Consensus	2
Endothelial Cell–Pericyte Interactions in the Pathogenesis of Cerebral Cavernous Malformations (CCMs)	2
The Role of B Lymphocytes in Type 1 Diabetes	2
Human Genomics and Drug Development	2
Geroscience and Its Promise	2
Integrating Omics into Functional Biomarkers of Type 1 Diabetes	2
Imaging Tumor Metabolism	2
Mouse Models to Evaluate the Functional Role of the Tumor Microenvironment in Cancer Progression and Therapy Responses	2
Oncogenic Control of Metabolism	2
Lessons Learned from Cancer Metabolism for Physiology and Disease	2
Overview of Retinal Gene Therapy: Current Status and Future Challenges	2
Prevention of Epithelial Ovarian Cancer	2
Mechanisms Regulating T Cell–Endothelial Cell Interactions	2
Photoreceptor Cell Replacement Using Pluripotent Stem Cells: Current Knowledge and Remaining Questions	2
Cancer Metabolism under Limiting Oxygen Conditions	2
Mitochondrial Targeted Interventions for Aging	2
Adoptive Cell Therapy for Pediatric Solid Tumors	2
Environmental Factors in Type 1 Diabetes	2
The Evolution and Biology of SARS-CoV-2 Variants	2
Molecular Mechanisms Driving Lymphedema and Other Lymphatic Anomalies	2
Corrigendum: Toward Retinal Organoids in High-Throughput	2
Advances in Studying Cancer Immunology in Mice	2