OOIR: Observatory of International Research

Papers

(The median citation count of Cold Spring Harbor Perspectives in Medicine is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Mendelian Randomization: Concepts and Scope	327
Mendelian Randomization	192
The Evolution and Biology of SARS-CoV-2 Variants	125
Using Mendelian Randomization to Improve the Design of Randomized Trials	109
Application of Radiomics and Artificial Intelligence for Lung Cancer Precision Medicine	48
Triangulating Evidence through the Inclusion of Genetically Informed Designs	40
Tumor Immunology and Immunotherapy of Non-Small-Cell Lung Cancer	31
The Evolution and Ecology of Resistance in Cancer Therapy	30
Human Genomics and Drug Development	23
Immunotherapy Approaches for Breast Cancer Patients in 2023	21
Buttons and Zippers: Endothelial Junctions in Lymphatic Vessels	21
Notch Signaling in the Vasculature: Angiogenesis and Angiocrine Functions	19
The Meaning of “Cause” in Genetics	15
Early Diagnosis and Screening for Lung Cancer	14
Lymphedema and Obesity	14
Platelets and (Lymph)angiogenesis	12
Dormancy in Breast Cancer	12
Targeting Angiogenesis via Resolution of Inflammation	11
Preclinical Models for the Study of Lung Cancer Pathogenesis and Therapy Development	10
Molecular Pathology of Lung Cancer	10
Endothelial Cell Fate Determination: A Top Notch Job in Vascular Decision-Making	10
Electronic Retinal Prostheses	9
Human Endothelial Colony-Forming Cells	9
Causal Inference with Genetic Data: Past, Present, and Future	8
Lessons Learned from the Development of the First FDA-Approved Gene Therapy Drug, Voretigene Neparvovec-rzyl	8

Endothelial Cell Differentiation and Hemogenic Specification	8
Radiation Therapy in Non-Small-Cell Lung Cancer	8
Endothelialitis, Microischemia, and Intussusceptive Angiogenesis in COVID-19	8
RPGR-Related Retinopathy: Clinical Features, Molecular Genetics, and Gene Replacement Therapy	7
Lung Cancer Stem Cells and Their Clinical Implications	7
Roles of NAD⁺in Health and Aging	7
Lymphatics in Cardiovascular Physiology	7
Aging and Inflammation	6
Notch Signaling in Vascular Endothelial and Mural Cell Communications	6
Developing New Vectors for Retinal Gene Therapy	6
Evolutionary Approaches in Aging Research	6
Mechanisms of Organ-Specific Metastasis of Breast Cancer	6
Overview of Retinal Gene Therapy: Current Status and Future Challenges	6
MicroRNAs in Mechanical Homeostasis	6
Past and Future Directions for Research on Cellular Senescence	6
Emerging Therapies for Breast Cancer	6
X-Linked Retinoschisis	6
High-Throughput Identification, Modeling, and Analysis of Cancer Driver Genes In Vivo	5
Endothelial Lipid Metabolism	5
The Role of the National Institute on Aging in the Development of the Field of Geroscience	5
Extracellular Matrix Regulation of Vascular Morphogenesis, Maturation, and Stabilization	5
Beyond the NEI-VFQ: Recent Experience in the Development and Utilization of Patient-Reported Outcomes for Inherited Retinal Diseases	4
Advances in Immunocompetent Mouse and Rat Models	4
A History of Cancer Research: Carcinogens and Mutagens	4
Epidemiology and Risk Factors for Breast Cancer: 21st Century Advances, Gaps to Address through Interdisciplinary Science	4
Gene Therapies for Retinitis Pigmentosa that Target Glucose Metabolism	4
Lymphatic Vascular Permeability	4
Multidimensional Imaging of Breast Cancer	4
Endothelial Cell–Pericyte Interactions in the Pathogenesis of Cerebral Cavernous Malformations (CCMs)	4
From Life Span to Health Span: Declaring “Victory” in the Pursuit of Human Longevity	4
Leukocyte Trafficking in Lymphatic Vessels	4
Alternative RNA Splicing in the Retina: Insights and Perspectives	4
Retraction: The Evolution and Ecology of Resistance in Cancer Therapy	4
Wnt/frizzled Signaling in Endothelium: A Major Player in Blood-Retinal- and Blood-Brain-Barrier Integrity	4
International Gains to Achieving Healthy Longevity	3
Metabolic Phenotypes, Dependencies, and Adaptation in Lung Cancer	3
Trial by “Firsts”: Clinical Trial Design and Regulatory Considerations in the Development and Approval of the First AAV Gene Therapy Product in the United States	3
Retinal Degeneration Animal Models in Bardet–Biedl Syndrome and Related Ciliopathies	3
Discovering Biological Mechanisms of Exceptional Human Health Span and Life Span	3
Mechanisms Regulating T Cell–Endothelial Cell Interactions	3
Choroideremia: Toward Regulatory Approval of Retinal Gene Therapy	3
Funding Life-Extension Research	3
Mutations, Bottlenecks, and Clonal Sweeps: How Environmental Carcinogens and Genomic Changes Shape Clonal Evolution during Tumor Progression	3
From Bench to Bedside—Delivering Gene Therapy for Leber Hereditary Optic Neuropathy	3
Gut Microbiota and the Microvasculature	3
Pathomechanisms of Inherited Retinal Degeneration and Perspectives for Neuroprotection	3
Modeling Brain Vasculature Immune Interactions In Vitro	3
Breast Cancer Immunity: It is TIME for the Next Chapter	3
Human Ductal Carcinoma In Situ: Advances and Future Perspectives	3
A Systematic Review of Optogenetic Vision Restoration: History, Challenges, and New Inventions from Bench to Bedside	3

Comparison of Worldwide Disease Prevalence and Genetic Prevalence of Inherited Retinal Diseases and Variant Interpretation Considerations	3
Computational Tools for Causal Inference in Genetics	3
Gene Therapy for Rhodopsin Mutations	2
Embryological Insights into the Origin of Epithelial Cancers of the Female Reproductive Tract	2
Preclinical Modeling of Pathway-Targeted Therapy of Human Lung Cancer in the Mouse	2
The Emerging Role of the Single-Cell and Spatial Tumor Microenvironment in High-Grade Serous Ovarian Cancer	2
Current Status of Clinical Trials Design and Outcomes in Retinal Gene Therapy	2
Cell-Based Therapies: Strategies for Regeneration	2
Therapeutic Gene Editing in Inherited Retinal Disorders	2
Lymphatic Tissue and Organ Engineering for In Vitro Modeling and In Vivo Regeneration	2
New Paradigms in the Clinical Management of Li–Fraumeni Syndrome	2
Diet and Cancer Metabolism	2
Adaptive Optics Imaging of Inherited Retinal Disease	2
Prevention of Epithelial Ovarian Cancer	2
Biological Restraints on Indefinite Survival	2
iPSC-RPE in Retinal Degeneration: Recent Advancements and Future Perspectives	2
Mitochondria and Cancer	2
Photoreceptor Cell Replacement Using Pluripotent Stem Cells: Current Knowledge and Remaining Questions	2
The Beauty and Complexity of Blood Vessel Patterning	2
The Power and Promise of Patient-Derived Xenografts of Human Breast Cancer	2
Influence of Aging Science on Global Wealth Management	2
How CRISPR Is Revolutionizing the Generation of New Models for Cancer Research	2
Early Detection of Ovarian Cancer	2
Organoid Cultures for the Study of Mammary Biology and Breast Cancer: The Promise and Challenges	2
Endothelial Connexins in Developmental and Pathological Angiogenesis	2
Mobility Testing and Other Performance-Based Assessments of Functional Vision in Patients with Inherited Retinal Disease	2
Cellular Origins and Lineage Plasticity in Cancer	2
Advances in Making Cancer Mouse Models More Accessible and Informative through Non-Germline Genetic Engineering	2
Chromatin Variants Reveal the Genetic Determinants of Oncogenesis in Breast Cancer	2