OOIR: Observatory of International Research

Papers

(The median citation count of Cold Spring Harbor Perspectives in Medicine is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Developmental Oncology: Principles and Therapy of Cancers of Children and Young Adults	366
iPSC-RPE in Retinal Degeneration: Recent Advancements and Future Perspectives	162
Developing New Vectors for Retinal Gene Therapy	68
Personalized Financial Planning Using Applied Genetics	45
Toward Retinal Organoids in High-Throughput	39
Ovarian Clear Cell Carcinoma: An Endometriosis-Associated Cancer with Therapeutic Challenges	37
Monitoring the Cell Cycle of Tumor Cells in Mouse Models of Human Cancer	37
Pathomechanisms of Inherited Retinal Degeneration and Perspectives for Neuroprotection	32
Metabolic Signaling in Cancer	31
How CRISPR Is Revolutionizing the Generation of New Models for Cancer Research	29
Genetics and Epigenetics of Type 1 Diabetes Self-Reactive T Cells	27
Embryological Insights into the Origin of Epithelial Cancers of the Female Reproductive Tract	27
Clinical Immunologic Interventions for the Treatment of Type 1 Diabetes: Challenges, Choice, and Timing of Immunomodulators	23
Inflammatory β-Cell Stress and Immune Surveillance in Type 1 Diabetes	21
From the Inside Out: Exposing the Roles of Urea Cycle Enzymes in Tumors and Their Micro and Macro Environments	20
α-Synuclein in Parkinson's Disease: 12 Years Later	20
Mechanisms of Organ-Specific Metastasis of Breast Cancer	20
Therapeutic Gene Editing in Inherited Retinal Disorders	19
Preclinical Models for the Study of Lung Cancer Pathogenesis and Therapy Development	17
Aging and Inflammation	16
Retinal Disorders	16
Functional Neuroanatomy of the Normal and Pathological Basal Ganglia	15
Optogenetic Vision Restoration	15
Autophagy and Protein Quality Control in Parkinson's Disease	14
Innate Immunity in Type 1 Diabetes	14

Endothelial Cell Differentiation and Hemogenic Specification	14
Breast Cancer Immunity: It is TIME for the Next Chapter	13
Immunology of Retinitis Pigmentosa and Gene Therapy–Associated Uveitis	13
Evolutionary Approaches in Aging Research	13
Lipid Alterations and Pathogenic Roles in Synucleinopathies	12
The Pathogenesis of Type 1 Diabetes	12
Acute Promyelocytic Leukemia, Retinoic Acid, and Arsenic: A Tale of Dualities	12
Epitope Hierarchy in Type 1 Diabetes Pathogenesis	12
Lessons Learned from the Development of the First FDA-Approved Gene Therapy Drug, Voretigene Neparvovec-rzyl	11
The Funding Channels of Geroscience	11
Early Detection of Ovarian Cancer	11
A History of Biosafety: U.S. Perspective	10
Beyond Static Pipes: Mechanisms and In Vitro Models of Vascular Aging	10
From Life Span to Health Span: Declaring “Victory” in the Pursuit of Human Longevity	10
Toward a Unified Theory of Why Young People Develop Cancer	10
Germline Genetic Testing for Hereditary Breast and Ovarian Cancer: Current Concepts in Risk Evaluation	10
Lymphatic Tissue and Organ Engineering for In Vitro Modeling and In Vivo Regeneration	10
The Human Pancreas in Type 1 Diabetes: Lessons Learned from the Network of Pancreatic Organ Donors with Diabetes	10
Comparison of Worldwide Disease Prevalence and Genetic Prevalence of Inherited Retinal Diseases and Variant Interpretation Considerations	9
Modeling Brain Vasculature Immune Interactions In Vitro	9
Understanding the Warburg Effect in Cancer	9
T Cell Differentiation in Autoimmune Type 1 Diabetes	9
Endothelial Lipid Metabolism	9
Wnt/frizzled Signaling in Endothelium: A Major Player in Blood-Retinal- and Blood-Brain-Barrier Integrity	9
Leucine-Rich Repeat Kinase 2: Pathways to Parkinson's Disease	8
The Power and Promise of Patient-Derived Xenografts of Human Breast Cancer	8
Next-Generation Modeling of Cancer Using Organoids	8
New Paradigms in the Clinical Management of Li–Fraumeni Syndrome	8
Technologies for Decoding Cancer Metabolism with Spatial Resolution	8
Dormancy in Breast Cancer	8
Emerging Therapies for Breast Cancer	8
Cellular Origins and Lineage Plasticity in Cancer	8
Notch Signaling in Vascular Endothelial and Mural Cell Communications	8
Retinal Degeneration Animal Models in Bardet–Biedl Syndrome and Related Ciliopathies	8
Rare Epithelial Ovarian Cancers: Low Grade Serous and Mucinous Carcinomas	8
Parallels in Canonical Developmental Signaling Pathways between Normal Development and the Tumor Microenvironment	8
Mechanics of Lymphatic Pumping and Lymphatic Function	7
The Extraordinary Phenotypic and Genetic Variability of Retinal and Macular Degenerations: The Relevance to Therapeutic Developments	7
Angiogenesis and Microvascular Permeability	7
Historical Perspectives of Parkinson's Disease: Early Clinical Descriptions and Neurological Therapies	7
History of Finding Genes and Mutations Causing Inherited Retinal Diseases	7
Lung Cancer Stem Cells and Their Clinical Implications	7
Osteosarcoma through the Lens of Bone Development, Signaling, and Microenvironment	7
Regulation of the Blood–Brain Barrier in Health and Disease	7
Canine and Feline Models of Inherited Retinal Diseases	6
Lymphedema and Obesity	6
Organoid Cultures for the Study of Mammary Biology and Breast Cancer: The Promise and Challenges	6
Human Endothelial Colony-Forming Cells	6
International Gains to Achieving Healthy Longevity	6
The Chicken or the Egg Dilemma: Understanding the Interplay between the Immune System and the β Cell in Type 1 Diabetes	6

Beyond the NEI-VFQ: Recent Experience in the Development and Utilization of Patient-Reported Outcomes for Inherited Retinal Diseases	6
Mobility Testing and Other Performance-Based Assessments of Functional Vision in Patients with Inherited Retinal Disease	6
Corrigendum: Preclinical Modeling of Pathway-Targeted Therapy of Human Lung Cancer in the Mouse	5
The Breast Cancer Proteome and Precision Oncology	5
Imaging of Disease-Related Networks in Parkinson's Disease	5
Molecular Pathology of Lung Cancer	5
Lymphatic Clearance and Pump Function	5
Advances in Making Cancer Mouse Models More Accessible and Informative through Non-Germline Genetic Engineering	5
Cell-Based Therapies: Strategies for Regeneration	5
Tracing the Diverse Paths of One-Carbon Metabolism in Cancer and Beyond	5
RPGR-Related Retinopathy: Clinical Features, Molecular Genetics, and Gene Replacement Therapy	5
Checkpoint Inhibitor-Induced Autoimmune Diabetes: An Autoinflammatory Disease	5
Developmental Heterogeneity of Rhabdomyosarcoma	5
Spatial Biology of Breast Cancer	5
Crowdfunding and Crowdsourcing of Aging Science	4
Cancer Therapies Targeting Cellular Metabolism	4
Chromatin Variants Reveal the Genetic Determinants of Oncogenesis in Breast Cancer	4
The Role of Stroma in Cancer Metabolism	4
Mouse Models to Evaluate the Functional Role of the Tumor Microenvironment in Cancer Progression and Therapy Responses	4
Restoration of Rod-Derived Metabolic and Redox Signaling to Prevent Blindness	4
Tumor Immunology and Immunotherapy of Non-Small-Cell Lung Cancer	4
Metabolic Reprogramming in Human Cancer Patients and Patient-Derived Models	4
Breakdown and Repair of Peripheral Immune Tolerance in Type 1 Diabetes	4
Biological Restraints on Indefinite Survival	4
Trial by “Firsts”: Clinical Trial Design and Regulatory Considerations in the Development and Approval of the First AAV Gene Therapy Product in the United States	4
Mendelian Randomization	4
From Bench to Bedside—Delivering Gene Therapy for Leber Hereditary Optic Neuropathy	4
Extracellular Matrix Regulation of Vascular Morphogenesis, Maturation, and Stabilization	4
Mutations, Bottlenecks, and Clonal Sweeps: How Environmental Carcinogens and Genomic Changes Shape Clonal Evolution during Tumor Progression	4
Threats from the Fungal Kingdom	4
Gene Therapies for Retinitis Pigmentosa that Target Glucose Metabolism	3
Imaging Tumor Metabolism	3
Cancer Metabolism Historical Perspectives: A Chronicle of Controversies and Consensus	3
Photoreceptor Cell Replacement Using Pluripotent Stem Cells: Current Knowledge and Remaining Questions	3
Molecular Mechanisms Driving Lymphedema and Other Lymphatic Anomalies	3
Mechanisms Regulating T Cell–Endothelial Cell Interactions	3
Endothelial Cell–Pericyte Interactions in the Pathogenesis of Cerebral Cavernous Malformations (CCMs)	3
Mitochondrial Targeted Interventions for Aging	3
Addendum to Dopamine Cell-Based Replacement Therapies	3
The Mitochondrial Connection in Parkinson's Disease	3
Environmental Factors in Type 1 Diabetes	3
Prevention of Epithelial Ovarian Cancer	3
Overview of Retinal Gene Therapy: Current Status and Future Challenges	3
Geroscience and Its Promise	3
Integrating Omics into Functional Biomarkers of Type 1 Diabetes	3
The Role of the National Institute on Aging in the Development of the Field of Geroscience	3
Cancer Metabolism under Limiting Oxygen Conditions	3
Adoptive Cell Therapy for Pediatric Solid Tumors	3
Corrigendum: Toward Retinal Organoids in High-Throughput	3
Oncogenic Control of Metabolism	3