OOIR: Observatory of International Research

Papers

(The median citation count of Cold Spring Harbor Perspectives in Medicine is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Developmental Oncology: Principles and Therapy of Cancers of Children and Young Adults	388
iPSC-RPE in Retinal Degeneration: Recent Advancements and Future Perspectives	166
Pathomechanisms of Inherited Retinal Degeneration and Perspectives for Neuroprotection	88
Personalized Financial Planning Using Applied Genetics	45
Monitoring the Cell Cycle of Tumor Cells in Mouse Models of Human Cancer	39
Developing New Vectors for Retinal Gene Therapy	38
Metabolic Signaling in Cancer	36
Toward Retinal Organoids in High-Throughput	32
Ovarian Clear Cell Carcinoma: An Endometriosis-Associated Cancer with Therapeutic Challenges	31
How CRISPR Is Revolutionizing the Generation of New Models for Cancer Research	27
Embryological Insights into the Origin of Epithelial Cancers of the Female Reproductive Tract	27
Inflammatory β-Cell Stress and Immune Surveillance in Type 1 Diabetes	26
Clinical Immunologic Interventions for the Treatment of Type 1 Diabetes: Challenges, Choice, and Timing of Immunomodulators	24
α-Synuclein in Parkinson's Disease: 12 Years Later	24
Genetics and Epigenetics of Type 1 Diabetes Self-Reactive T Cells	21
Mechanisms of Organ-Specific Metastasis of Breast Cancer	20
From the Inside Out: Exposing the Roles of Urea Cycle Enzymes in Tumors and Their Micro and Macro Environments	18
Therapeutic Gene Editing in Inherited Retinal Disorders	17
Optogenetic Vision Restoration	17
Retinal Disorders	16
Functional Neuroanatomy of the Normal and Pathological Basal Ganglia	16
Aging and Inflammation	16
Endothelial Cell Differentiation and Hemogenic Specification	15
Autophagy and Protein Quality Control in Parkinson's Disease	15
Who Are the Space Invaders? Planetary Protection and the Role of Biological Interactions between Extraterrestrial and Terrestrial Biospheres	13

Immunology of Retinitis Pigmentosa and Gene Therapy–Associated Uveitis	13
Epitope Hierarchy in Type 1 Diabetes Pathogenesis	13
Innate Immunity in Type 1 Diabetes	13
The Funding Channels of Geroscience	12
Lipid Alterations and Pathogenic Roles in Synucleinopathies	12
The Pathogenesis of Type 1 Diabetes	12
From Life Span to Health Span: Declaring “Victory” in the Pursuit of Human Longevity	11
Early Detection of Ovarian Cancer	11
Breast Cancer Immunity: It is TIME for the Next Chapter	11
Models of High-Grade Serous Ovarian Carcinoma	11
Evolutionary Approaches in Aging Research	10
Toward a Unified Theory of Why Young People Develop Cancer	10
Germline Genetic Testing for Hereditary Breast and Ovarian Cancer: Current Concepts in Risk Evaluation	10
Lessons Learned from the Development of the First FDA-Approved Gene Therapy Drug, Voretigene Neparvovec-rzyl	10
Beyond Static Pipes: Mechanisms and In Vitro Models of Vascular Aging	10
Lymphatic Tissue and Organ Engineering for In Vitro Modeling and In Vivo Regeneration	10
Acute Promyelocytic Leukemia, Retinoic Acid, and Arsenic: A Tale of Dualities	10
The Human Pancreas in Type 1 Diabetes: Lessons Learned from the Network of Pancreatic Organ Donors with Diabetes	10
A History of Biosafety: U.S. Perspective	10
Modeling Brain Vasculature Immune Interactions In Vitro	9
Comparison of Worldwide Disease Prevalence and Genetic Prevalence of Inherited Retinal Diseases and Variant Interpretation Considerations	9
T Cell Differentiation in Autoimmune Type 1 Diabetes	9
Dormancy in Breast Cancer	9
Wnt/frizzled Signaling in Endothelium: A Major Player in Blood-Retinal- and Blood-Brain-Barrier Integrity	9
Understanding the Warburg Effect in Cancer	9
Endothelial Lipid Metabolism	9
Notch Signaling in Vascular Endothelial and Mural Cell Communications	8
The Power and Promise of Patient-Derived Xenografts of Human Breast Cancer	8
The Extraordinary Phenotypic and Genetic Variability of Retinal and Macular Degenerations: The Relevance to Therapeutic Developments	8
Next-Generation Modeling of Cancer Using Organoids	8
Retinal Degeneration Animal Models in Bardet–Biedl Syndrome and Related Ciliopathies	8
Cellular Origins and Lineage Plasticity in Cancer	8
Technologies for Decoding Cancer Metabolism with Spatial Resolution	8
New Paradigms in the Clinical Management of Li–Fraumeni Syndrome	8
Leucine-Rich Repeat Kinase 2: Pathways to Parkinson's Disease	8
Rare Epithelial Ovarian Cancers: Low Grade Serous and Mucinous Carcinomas	8
Parallels in Canonical Developmental Signaling Pathways between Normal Development and the Tumor Microenvironment	8
Emerging Therapies for Breast Cancer	8
Historical Perspectives of Parkinson's Disease: Early Clinical Descriptions and Neurological Therapies	7
Canine and Feline Models of Inherited Retinal Diseases	7
Mechanics of Lymphatic Pumping and Lymphatic Function	7
Safety and Security in the Lithotroph of Microbiology—A Commentary	7
Angiogenesis and Microvascular Permeability	7
Lymphedema and Obesity	7
History of Finding Genes and Mutations Causing Inherited Retinal Diseases	7
Osteosarcoma through the Lens of Bone Development, Signaling, and Microenvironment	7
Beyond the NEI-VFQ: Recent Experience in the Development and Utilization of Patient-Reported Outcomes for Inherited Retinal Diseases	7
The Chicken or the Egg Dilemma: Understanding the Interplay between the Immune System and the β Cell in Type 1 Diabetes	6
Mobility Testing and Other Performance-Based Assessments of Functional Vision in Patients with Inherited Retinal Disease	6
Advances in Making Cancer Mouse Models More Accessible and Informative through Non-Germline Genetic Engineering	6

Corrigendum: Preclinical Modeling of Pathway-Targeted Therapy of Human Lung Cancer in the Mouse	6
Parkinson's Disease, Second Edition	6
Checkpoint Inhibitor-Induced Autoimmune Diabetes: An Autoinflammatory Disease	6
The Breast Cancer Proteome and Precision Oncology	6
Regulation of the Blood–Brain Barrier in Health and Disease	6
Human Endothelial Colony-Forming Cells	6
Cell-Based Therapies: Strategies for Regeneration	6
Tracing the Diverse Paths of One-Carbon Metabolism in Cancer and Beyond	5
Mendelian Randomization	5
Organoid Cultures for the Study of Mammary Biology and Breast Cancer: The Promise and Challenges	5
Spatial Biology of Breast Cancer	5
RPGR-Related Retinopathy: Clinical Features, Molecular Genetics, and Gene Replacement Therapy	5
Cancer Therapies Targeting Cellular Metabolism	5
Developmental Heterogeneity of Rhabdomyosarcoma	5
Lymphatic Clearance and Pump Function	5
Molecular Pathology of Lung Cancer	5
Metabolic Reprogramming in Human Cancer Patients and Patient-Derived Models	5
International Gains to Achieving Healthy Longevity	5
Imaging of Disease-Related Networks in Parkinson's Disease	5
Crowdfunding and Crowdsourcing of Aging Science	4
Breakdown and Repair of Peripheral Immune Tolerance in Type 1 Diabetes	4
Mouse Models to Evaluate the Functional Role of the Tumor Microenvironment in Cancer Progression and Therapy Responses	4
Mutations, Bottlenecks, and Clonal Sweeps: How Environmental Carcinogens and Genomic Changes Shape Clonal Evolution during Tumor Progression	4
Addendum to Dopamine Cell-Based Replacement Therapies	4
Extracellular Matrix Regulation of Vascular Morphogenesis, Maturation, and Stabilization	4
Threats from the Fungal Kingdom	4
The Role of Stroma in Cancer Metabolism	4
Biological Restraints on Indefinite Survival	4
Trial by “Firsts”: Clinical Trial Design and Regulatory Considerations in the Development and Approval of the First AAV Gene Therapy Product in the United States	4
Gene Therapies for Retinitis Pigmentosa that Target Glucose Metabolism	4
Restoration of Rod-Derived Metabolic and Redox Signaling to Prevent Blindness	4
From Bench to Bedside—Delivering Gene Therapy for Leber Hereditary Optic Neuropathy	4
Chromatin Variants Reveal the Genetic Determinants of Oncogenesis in Breast Cancer	4
The Mitochondrial Connection in Parkinson's Disease	4
The Role of the National Institute on Aging in the Development of the Field of Geroscience	4
Cancer Metabolism Historical Perspectives: A Chronicle of Controversies and Consensus	4
Mitochondrial Targeted Interventions for Aging	3
Oncogenic Control of Metabolism	3
Photoreceptor Cell Replacement Using Pluripotent Stem Cells: Current Knowledge and Remaining Questions	3
Corrigendum: Toward Retinal Organoids in High-Throughput	3
Innate Immunity and Parkinson's Disease	3
Adoptive Cell Therapy for Pediatric Solid Tumors	3
Integrating Omics into Functional Biomarkers of Type 1 Diabetes	3
Environmental Factors in Type 1 Diabetes	3
Geroscience and Its Promise	3
Molecular Mechanisms Driving Lymphedema and Other Lymphatic Anomalies	3
Overview of Retinal Gene Therapy: Current Status and Future Challenges	3
Imaging Tumor Metabolism	3
Cancer Metabolism under Limiting Oxygen Conditions	3
Mechanisms Regulating T Cell–Endothelial Cell Interactions	3
Endothelial Cell–Pericyte Interactions in the Pathogenesis of Cerebral Cavernous Malformations (CCMs)	3
Clinical Management of Parkinson's Disease: Features, Diagnosis, and Principles of Treatment	3
Advances in Studying Cancer Immunology in Mice	3